{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:16:18Z","timestamp":1788837378746,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Science and Technology Program of Jiangxi Traditional Chinese Medicine","award":["2021B723"],"award-info":[{"award-number":["2021B723"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["82260085"],"award-info":[{"award-number":["82260085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00203-024-04130-0","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T16:02:20Z","timestamp":1726070540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of male hormones in bacterial infections: enhancing Staphylococcus aureus virulence through testosterone-induced Agr activation"],"prefix":"10.1007","volume":"206","author":[{"given":"Zhaoxia","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-yun","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"4130_CR1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","volume":"630","author":"J Abramson","year":"2024","unstructured":"Abramson J, Adler J, Dunger J et al (2024) Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630:493\u2013500. https:\/\/doi.org\/10.1038\/s41586-024-07487-w","journal-title":"Nature"},{"key":"4130_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12088-015-0555-3","volume":"56","author":"R Arya","year":"2016","unstructured":"Arya R, Princy SA (2016) Exploration of modulated genetic circuits governing virulence determinants in Staphylococcus aureus. Indian J Microbiol 56:19\u201327. https:\/\/doi.org\/10.1007\/s12088-015-0555-3","journal-title":"Indian J Microbiol"},{"key":"4130_CR3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.plasmid.2005.05.005","volume":"55","author":"T Bae","year":"2006","unstructured":"Bae T, Schneewind O (2006) Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid 55:58\u201363. https:\/\/doi.org\/10.1016\/j.plasmid.2005.05.005","journal-title":"Plasmid"},{"key":"4130_CR5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.20072208","volume":"205","author":"J Bubeck Wardenburg","year":"2008","unstructured":"Bubeck Wardenburg J, Schneewind O (2008) Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med 205:287\u2013294. https:\/\/doi.org\/10.1084\/jem.20072208","journal-title":"J Exp Med"},{"key":"4130_CR4","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/nm1207-1405","volume":"13","author":"J Bubeck Wardenburg","year":"2007","unstructured":"Bubeck Wardenburg J, Bae T, Otto M et al (2007) Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 13:1405\u20131406. https:\/\/doi.org\/10.1038\/nm1207-1405","journal-title":"Nat Med"},{"key":"4130_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3390\/toxins12080516","volume":"12","author":"CE Butrico","year":"2020","unstructured":"Butrico CE, Cassat JE (2020) Quorum Sensing and Toxin Production in Staphylococcus aureus Osteomyelitis: Pathogenesis and Paradox. Toxins (Basel) 12:516. https:\/\/doi.org\/10.3390\/toxins12080516","journal-title":"Toxins (Basel)"},{"key":"4130_CR7","doi-asserted-by":"publisher","first-page":"20203","DOI":"10.1038\/s41598-019-56666-7","volume":"9","author":"M Cambronel","year":"2019","unstructured":"Cambronel M, Tortuel D, Biaggini K et al (2019) Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103. Sci Rep 9:20203. https:\/\/doi.org\/10.1038\/s41598-019-56666-7","journal-title":"Sci Rep"},{"key":"4130_CR8","doi-asserted-by":"publisher","first-page":"657","DOI":"10.4049\/jimmunol.1700810","volume":"200","author":"MJ Castleman","year":"2018","unstructured":"Castleman MJ, Pokhrel S, Triplett KD et al (2018) Innate sex Bias of Staphylococcus aureus skin infection is driven by alpha-hemolysin. J Immunol 200:657\u2013668. https:\/\/doi.org\/10.4049\/jimmunol.1700810","journal-title":"J Immunol"},{"key":"4130_CR10","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1128\/IAI.00046-11","volume":"79","author":"GYC Cheung","year":"2011","unstructured":"Cheung GYC, Wang R, Khan BA et al (2011) Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun 79:1927\u20131935. https:\/\/doi.org\/10.1128\/IAI.00046-11","journal-title":"Infect Immun"},{"key":"4130_CR9","doi-asserted-by":"publisher","unstructured":"Cheung GYC, Bae JS, Otto M (2021) Pathogenicity and virulence of Staphylococcus aureus. Virulence 12:547\u2013569. https:\/\/doi.org\/10.1080\/21505594.2021.1878688","DOI":"10.1080\/21505594.2021.1878688"},{"issue":"4","key":"4130_CR11","doi-asserted-by":"publisher","first-page":"e0123027","DOI":"10.1371\/journal.pone.0123027","volume":"10","author":"D Cue","year":"2015","unstructured":"Cue D, Junecko JM, Lei MG (2015) SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS ONE 10(4):e0123027. https:\/\/doi.org\/10.1371\/journal.pone.0123027","journal-title":"PLoS ONE"},{"issue":"1","key":"4130_CR12","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41426-018-0142-x","volume":"7","author":"J Duan","year":"2018","unstructured":"Duan J, Li M, Hao Z et al (2018) Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS. Emerg Microbes Infect 7(1):136. https:\/\/doi.org\/10.1038\/s41426-018-0142-x","journal-title":"Emerg Microbes Infect"},{"issue":"4","key":"4130_CR13","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/path.1700620405","volume":"62","author":"SD ELEK","year":"1950","unstructured":"ELEK SD, LEVY E (1950) Distribution of haemolysins in pathogenic and non-pathogenic staphylococci. J Pathol Bacteriol 62(4):541\u2013554. https:\/\/doi.org\/10.1002\/path.1700620405","journal-title":"J Pathol Bacteriol"},{"key":"4130_CR14","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1128\/JCM.38.3.1008-1015.2000","volume":"38","author":"MC Enright","year":"2000","unstructured":"Enright MC, Day NP, Davies CE et al (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38:1008\u20131015. https:\/\/doi.org\/10.1128\/JCM.38.3.1008-1015.2000","journal-title":"J Clin Microbiol"},{"key":"4130_CR15","doi-asserted-by":"publisher","unstructured":"Gao P, Wei Y, Hou S et al (2023) SaeR as a novel target for antivirulence therapy against Staphylococcus aureus. Emerg Microbes Infect 12:2254415. https:\/\/doi.org\/10.1080\/22221751.2023.2254415","DOI":"10.1080\/22221751.2023.2254415"},{"issue":"38","key":"4130_CR16","doi-asserted-by":"publisher","first-page":"19145","DOI":"10.1073\/pnas.1902752116","volume":"116","author":"SE George","year":"2019","unstructured":"George SE, Hrubesch J, Breuing I et al (2019) Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population. Proc Natl Acad Sci U S A 116(38):19145\u201319154. https:\/\/doi.org\/10.1073\/pnas.1902752116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4130_CR17","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1128\/JCM.40.11.4060-4067.2002","volume":"40","author":"P Gilot","year":"2002","unstructured":"Gilot P, Lina G, Cochard T, Poutrel B (2002) Analysis of the genetic variability of genes encoding the RNA III-Activating components agr and TRAP in a Population of Staphylococcus aureus strains isolated from cows with Mastitis. J Clin Microbiol 40:4060\u20134067. https:\/\/doi.org\/10.1128\/JCM.40.11.4060-4067.2002","journal-title":"J Clin Microbiol"},{"key":"4130_CR18","doi-asserted-by":"publisher","first-page":"G1238","DOI":"10.1152\/ajpgi.00471.2003","volume":"287","author":"BT Green","year":"2004","unstructured":"Green BT, Lyte M, Chen C et al (2004) Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa. Am J Physiol Gastrointest Liver Physiol 287:G1238\u20131246. https:\/\/doi.org\/10.1152\/ajpgi.00471.2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4130_CR19","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/82_2015_5019","volume":"409","author":"AF Haag","year":"2017","unstructured":"Haag AF, Bagnoli F (2017) The role of Two-Component Signal Transduction Systems in Staphylococcus aureus Virulence Regulation. Curr Top Microbiol Immunol 409:145\u2013198. https:\/\/doi.org\/10.1007\/82_2015_5019","journal-title":"Curr Top Microbiol Immunol"},{"key":"4130_CR20","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3389\/fcimb.2016.00180","volume":"6","author":"E Hodille","year":"2016","unstructured":"Hodille E, Cuerq C, Badiou C et al (2016) Delta Hemolysin and Phenol-Soluble Modulins, but not alpha hemolysin or Panton-Valentine Leukocidin, induce mast cell activation. Front Cell Infect Microbiol 6:180. https:\/\/doi.org\/10.3389\/fcimb.2016.00180","journal-title":"Front Cell Infect Microbiol"},{"key":"4130_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-022-03839-2","volume":"5","author":"Z Hu","year":"2022","unstructured":"Hu Z, Kopparapu PK, Ebner P et al (2022) Phenol-soluble modulin \u03b1 and \u03b2 display divergent roles in mice with staphylococcal septic arthritis. Commun Biol 5:1\u201311. https:\/\/doi.org\/10.1038\/s42003-022-03839-2","journal-title":"Commun Biol"},{"key":"4130_CR22","doi-asserted-by":"publisher","first-page":"114038","DOI":"10.1016\/j.physbeh.2022.114038","volume":"259","author":"S Ivan","year":"2023","unstructured":"Ivan S, Daniela O, Jaroslava BD (2023) Sex differences matter: males and females are equal but not the same. Physiol Behav 259:114038. https:\/\/doi.org\/10.1016\/j.physbeh.2022.114038","journal-title":"Physiol Behav"},{"key":"4130_CR23","doi-asserted-by":"publisher","unstructured":"Jenul C, Horswill AR (2019) Regulation of Staphylococcus aureus Virulence. Microbiol Spectr 7. https:\/\/doi.org\/10.1128\/microbiolspec.GPP3-0031-2018","DOI":"10.1128\/microbiolspec.GPP3-0031-2018"},{"key":"4130_CR24","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ebiom.2016.05.037","volume":"9","author":"LD Knecht","year":"2016","unstructured":"Knecht LD, O\u2019Connor G, Mittal R et al (2016) Serotonin activates bacterial quorum sensing and enhances the virulence of Pseudomonas aeruginosa in the host. EBioMedicine 9:161\u2013169. https:\/\/doi.org\/10.1016\/j.ebiom.2016.05.037","journal-title":"EBioMedicine"},{"key":"4130_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10822-010-9395-8","volume":"25","author":"MA Lill","year":"2011","unstructured":"Lill MA, Danielson ML (2011) Computer-aided drug design platform using PyMOL. J Comput Aided Mol Des 25:13\u201319. https:\/\/doi.org\/10.1007\/s10822-010-9395-8","journal-title":"J Comput Aided Mol Des"},{"key":"4130_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"4130_CR27","doi-asserted-by":"publisher","first-page":"1328947","DOI":"10.3389\/fmicb.2023.1328947","volume":"14","author":"Z Luo","year":"2023","unstructured":"Luo Z, Li Y, Liu M, Zhao R (2023) Ciprofloxacin enhances the biofilm formation of Staphylococcus aureus via an agrc-dependent mechanism. Front Microbiol 14:1328947. https:\/\/doi.org\/10.3389\/fmicb.2023.1328947","journal-title":"Front Microbiol"},{"key":"4130_CR28","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris GM, Huey R, Lindstrom W et al (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30:2785\u20132791. https:\/\/doi.org\/10.1002\/jcc.21256","journal-title":"J Comput Chem"},{"issue":"551","key":"4130_CR29","doi-asserted-by":"publisher","first-page":"eaay4068","DOI":"10.1126\/scitranslmed.aay4068","volume":"12","author":"Y Nakamura","year":"2020","unstructured":"Nakamura Y, Takahashi H, Takaya A et al (2020) Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development. Sci Transl Med 12(551):eaay4068. https:\/\/doi.org\/10.1126\/scitranslmed.aay4068","journal-title":"Sci Transl Med"},{"key":"4130_CR30","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.3389\/fmicb.2018.03085","volume":"9","author":"TK Nygaard","year":"2018","unstructured":"Nygaard TK, Borgogna TR, Sward EW et al (2018) Aspartic acid Residue 51 of SaeR is essential for Staphylococcus aureus Virulence. Front Microbiol 9:3085. https:\/\/doi.org\/10.3389\/fmicb.2018.03085","journal-title":"Front Microbiol"},{"key":"4130_CR31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1146\/annurev.micro.112408.134309","volume":"64","author":"M Otto","year":"2010","unstructured":"Otto M (2010) Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol 64:143\u2013162. https:\/\/doi.org\/10.1146\/annurev.micro.112408.134309","journal-title":"Annu Rev Microbiol"},{"key":"4130_CR32","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrmicro3110","volume":"11","author":"A Peschel","year":"2013","unstructured":"Peschel A, Otto M (2013) Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol 11:667\u2013673. https:\/\/doi.org\/10.1038\/nrmicro3110","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"4130_CR33","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/infdis\/jiac191","volume":"226","author":"E Ramond","year":"2022","unstructured":"Ramond E, Lepissier A, Ding X et al (2022) Lung-adapted Staphylococcus aureus isolates with dysfunctional agr system trigger a Proinflammatory response. J Infect Dis 226(7):1276\u20131285. https:\/\/doi.org\/10.1093\/infdis\/jiac191","journal-title":"J Infect Dis"},{"key":"4130_CR34","doi-asserted-by":"publisher","first-page":"770657","DOI":"10.3389\/fmicb.2021.770657","volume":"12","author":"L Rao","year":"2022","unstructured":"Rao L, Yu J, Wang B et al (2022) Small-molecule compound SYG-180-2-2 to effectively prevent the Biofilm formation of Methicillin-Resistant Staphylococcus aureus. Front Microbiol 12:770657. https:\/\/doi.org\/10.3389\/fmicb.2021.770657","journal-title":"Front Microbiol"},{"issue":"3","key":"4130_CR35","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1128\/AAC.00918-10","volume":"55","author":"ML Schweizer","year":"2011","unstructured":"Schweizer ML, Furuno JP, Sakoulas G et al (2011) Increased mortality with accessory gene regulator (agr) dysfunction in Staphylococcus aureus among bacteremic patients. Antimicrob Agents Chemother 55(3):1082\u20131087. https:\/\/doi.org\/10.1128\/AAC.00918-10","journal-title":"Antimicrob Agents Chemother"},{"key":"4130_CR36","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12864-021-08167-z","volume":"23","author":"VK Sharma","year":"2022","unstructured":"Sharma VK, Akavaram S, Bayles DO (2022) Genomewide transcriptional response of Escherichia coli O157:H7 to norepinephrine. BMC Genomics 23:107. https:\/\/doi.org\/10.1186\/s12864-021-08167-z","journal-title":"BMC Genomics"},{"key":"4130_CR37","doi-asserted-by":"publisher","first-page":"e00409","DOI":"10.1128\/JB.00409-19","volume":"201","author":"TJ Sloan","year":"2019","unstructured":"Sloan TJ, Murray E, Yokoyama M et al (2019) Timing is everything: impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on Autoinduction. J Bacteriol 201:e00409\u2013e00419. https:\/\/doi.org\/10.1128\/JB.00409-19","journal-title":"J Bacteriol"},{"key":"4130_CR38","doi-asserted-by":"publisher","unstructured":"Stefani S, Goglio A (2010) Methicillin-resistant Staphylococcus aureus: related infections and antibiotic resistance. Int J Infect Dis 14 Suppl 4S19\u201322. https:\/\/doi.org\/10.1016\/j.ijid.2010.05.009","DOI":"10.1016\/j.ijid.2010.05.009"},{"key":"4130_CR39","doi-asserted-by":"publisher","first-page":"e01105","DOI":"10.1128\/mBio.01105-19","volume":"10","author":"EJ Steinig","year":"2019","unstructured":"Steinig EJ, Duchene S, Robinson DA et al (2019) Evolution and global transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian subcontinent. mBio 10:e01105\u2013e01119. https:\/\/doi.org\/10.1128\/mBio.01105-19","journal-title":"mBio"},{"key":"4130_CR40","doi-asserted-by":"publisher","first-page":"X3","DOI":"10.1530\/EJE-20-0877e","volume":"184","author":"DB Stensen","year":"2021","unstructured":"Stensen DB, Sm\u00e5brekke L, Olsen K et al (2021) Circulating sex-steroids and Staphylococcus aureus nasal carriage in a general female population. Eur J Endocrinol 184:X3. https:\/\/doi.org\/10.1530\/EJE-20-0877e","journal-title":"Eur J Endocrinol"},{"key":"4130_CR41","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/cmi.12130","volume":"15","author":"BGJ Surewaard","year":"2013","unstructured":"Surewaard BGJ, de Haas CJC, Vervoort F et al (2013) Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis. Cell Microbiol 15:1427\u20131437. https:\/\/doi.org\/10.1111\/cmi.12130","journal-title":"Cell Microbiol"},{"key":"4130_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fmicb.2018.00055","volume":"9","author":"L Tan","year":"2018","unstructured":"Tan L, Li SR, Jiang B et al (2018) Therapeutic targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) system. Front Microbiol 9:55. https:\/\/doi.org\/10.3389\/fmicb.2018.00055","journal-title":"Front Microbiol"},{"key":"4130_CR43","doi-asserted-by":"publisher","first-page":"1292233","DOI":"10.3389\/fcimb.2023.1292233","volume":"13","author":"A Thiroux","year":"2023","unstructured":"Thiroux A, Berjeaud JM, Vill\u00e9ger R et al (2023) Effect of endocrine disruptors on bacterial virulence. Front Cell Infect Microbiol 13:1292233. https:\/\/doi.org\/10.3389\/fcimb.2023.1292233","journal-title":"Front Cell Infect Microbiol"},{"key":"4130_CR44","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1128\/CMR.00134-14","volume":"28","author":"SYC Tong","year":"2015","unstructured":"Tong SYC, Davis JS, Eichenberger E et al (2015) Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev 28:603\u2013661. https:\/\/doi.org\/10.1128\/CMR.00134-14","journal-title":"Clin Microbiol Rev"},{"issue":"Pt 8","key":"4130_CR45","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1099\/mic.0.2007\/011874-0","volume":"154","author":"KE Traber","year":"2008","unstructured":"Traber KE, Lee E, Benson S et al (2008) Agr function in clinical Staphylococcus aureus isolates. Microbiol (Reading) 154(Pt 8):2265\u20132274. https:\/\/doi.org\/10.1099\/mic.0.2007\/011874-0","journal-title":"Microbiol (Reading)"},{"key":"4130_CR46","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.meegid.2013.04.030","volume":"21","author":"A-C Uhlemann","year":"2014","unstructured":"Uhlemann A-C, Otto M, Lowy FD, DeLeo FR (2014) Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus. Infect Genet Evol 21:563\u2013574. https:\/\/doi.org\/10.1016\/j.meegid.2013.04.030","journal-title":"Infect Genet Evol"},{"key":"4130_CR48","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1038\/nm1656","volume":"13","author":"R Wang","year":"2007","unstructured":"Wang R, Braughton KR, Kretschmer D et al (2007) Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 13:1510\u20131514. https:\/\/doi.org\/10.1038\/nm1656","journal-title":"Nat Med"},{"key":"4130_CR47","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.molcel.2014.02.029","volume":"53","author":"B Wang","year":"2014","unstructured":"Wang B, Zhao A, Novick R, Muir TW (2014) Activation and inhibition of the receptor histidine kinase AgrC occurs through Opposite Helical transduction motions. Mol Cell 53:929\u2013940. https:\/\/doi.org\/10.1016\/j.molcel.2014.02.029","journal-title":"Mol Cell"},{"key":"4130_CR49","doi-asserted-by":"publisher","first-page":"1422747","DOI":"10.3389\/fmicb.2024.1422747","volume":"15","author":"R Wu","year":"2024","unstructured":"Wu R, Pettersson C, Demirel I (2024) Testosterone increases the virulence traits of uropathogenic Escherichia coli. Front Microbiol 15:1422747. https:\/\/doi.org\/10.3389\/fmicb.2024.1422747","journal-title":"Front Microbiol"},{"issue":"11","key":"4130_CR50","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1172\/JCI20442","volume":"112","author":"JM Yarwood","year":"2003","unstructured":"Yarwood JM, Schlievert PM (2003) Quorum sensing in Staphylococcus infections. J Clin Invest 112(11):1620\u20131625. https:\/\/doi.org\/10.1172\/JCI20442","journal-title":"J Clin Invest"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-024-04130-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-024-04130-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-024-04130-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T23:02:54Z","timestamp":1728514974000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-024-04130-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4130"],"URL":"https:\/\/doi.org\/10.1007\/s00203-024-04130-0","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]},"assertion":[{"value":"28 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was approved by the ethical committee of the First Affiliated Hospital of Nanchang University (Jiangxi Province, China). All animal experiments were approved by the Animal Welfare and Ethics Committees of the First Affiliated Hospital of Nanchang University and complied with the Ethics Committee of Laboratory Animals and guidelines of the Institutional Administrative Committee (X20211031).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"401"}}