{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:40:05Z","timestamp":1747651205855,"version":"3.40.5"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007854","name":"Central Institute of Medicinal and Aromatic Plants","doi-asserted-by":"publisher","award":["HCP007"],"award-info":[{"award-number":["HCP007"]}],"id":[{"id":"10.13039\/501100007854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00203-025-04321-3","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:36:24Z","timestamp":1745307384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species"],"prefix":"10.1007","volume":"207","author":[{"given":"Saurabh","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak Singh","family":"Kapkoti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja Rani","family":"Mina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajeet Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parmanand","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Ramdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karuna","family":"Shanker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra Singh","family":"Bhakuni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra P.","family":"Darokar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"4321_CR1","doi-asserted-by":"publisher","first-page":"1374735","DOI":"10.3389\/fcell.2024.1374735","volume":"12","author":"AG Adegboro","year":"2024","unstructured":"Adegboro AG, Afolabi IS (2024) Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions. Front Cell Dev Biology 12:1374735","journal-title":"Front Cell Dev Biology"},{"key":"4321_CR2","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.3390\/molecules24193601","volume":"24","author":"S Alven","year":"2019","unstructured":"Alven S, Aderibigbe BJM (2019) Combination therapy strategies for the treatment of malaria. Molecules 24:3601","journal-title":"Molecules"},{"key":"4321_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s10787-023-01152-w","volume":"31","author":"V Babu","year":"2023","unstructured":"Babu V et al (2023) Liquiritigenin, Isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats. Inflammopharmacology 31:983\u2013996","journal-title":"Inflammopharmacology"},{"key":"4321_CR4","doi-asserted-by":"crossref","unstructured":"Becker K, Koncarevic S, Hunt NH (2005) Oxidative stress and antioxidant defense in malarial parasites. Molecular approaches to malaria:365\u2013383","DOI":"10.1128\/9781555817558.ch19"},{"key":"4321_CR5","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s10787-021-00920-w","volume":"30","author":"D Bhatt","year":"2022","unstructured":"Bhatt D et al (2022) Rutin ameliorates malaria pathogenesis by modulating inflammatory mechanism: an in vitro and in vivo study. Inflammopharmacology 30:159\u2013171","journal-title":"Inflammopharmacology"},{"key":"4321_CR6","doi-asserted-by":"publisher","first-page":"155943","DOI":"10.1016\/j.phymed.2024.155943","volume":"133","author":"D Bhatt","year":"2024","unstructured":"Bhatt D, Washimkar KR, Kumar S, Mugale MN, Pal A, Bawankule DU (2024) Naringin and chloroquine combination mitigates chloroquine-resistant parasite-induced malaria pathogenesis by attenuating the inflammatory response. Phytomedicine 133:155943","journal-title":"Phytomedicine"},{"key":"4321_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.parint.2013.12.005","volume":"63","author":"HS Cheema","year":"2014","unstructured":"Cheema HS, Prakash O, Pal A, Khan F, Bawankule DU, Darokar MP (2014) Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite plasmodium falciparum. Parasitol Int 63:349\u2013358","journal-title":"Parasitol Int"},{"key":"4321_CR8","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.3390\/ijms25021314","volume":"25","author":"T-H Chen","year":"2024","unstructured":"Chen T-H, Wang H-C, Chang C-J, Lee S-Y (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci 25:1314","journal-title":"Int J Mol Sci"},{"key":"4321_CR9","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1128\/AAC.01238-06","volume":"51","author":"L Cui","year":"2007","unstructured":"Cui L, Miao J, Cui L (2007) Cytotoxic effect of Curcumin on malaria parasite plasmodium falciparum: Inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob Agents Chemother 51:488\u2013494","journal-title":"Antimicrob Agents Chemother"},{"key":"4321_CR10","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ymeth.2007.11.008","volume":"44","author":"Z Darzynkiewicz","year":"2008","unstructured":"Darzynkiewicz Z, Galkowski D, Zhao H (2008) Analysis of apoptosis by cytometry using TUNEL assay. Methods 44:250\u2013254","journal-title":"Methods"},{"key":"4321_CR11","doi-asserted-by":"publisher","first-page":"1368765","DOI":"10.3389\/fphar.2024.1368765","volume":"15","author":"M Ding","year":"2024","unstructured":"Ding M et al (2024) Potential mechanisms of Formononetin against inflammation and oxidative stress: a review. Front Pharmacol 15:1368765","journal-title":"Front Pharmacol"},{"key":"4321_CR12","doi-asserted-by":"publisher","first-page":"1226044","DOI":"10.3389\/fcell.2023.1226044","volume":"11","author":"HT Endale","year":"2023","unstructured":"Endale HT, Tesfaye W, Mengstie TA (2023) ROS-induced lipid peroxidation and their role in ferroptosis. Front Cell Dev Biology 11:1226044","journal-title":"Front Cell Dev Biology"},{"key":"4321_CR13","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/nrmicro3138","volume":"11","author":"EL Flannery","year":"2013","unstructured":"Flannery EL, Chatterjee AK, Winzeler EAJNRM (2013) Antimalarial drug discovery\u2014approaches and progress towards new medicines. Nat Rev Microbiol 11:849\u2013862","journal-title":"Nat Rev Microbiol"},{"key":"4321_CR14","first-page":"453","volume":"57","author":"S Gawe\u0142","year":"2004","unstructured":"Gawe\u0142 S, Wardas M, Niedworok E, Wardas P (2004) Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek 57:453\u2013455","journal-title":"Wiad Lek"},{"key":"4321_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1128\/AAC.03663-14","volume":"59","author":"AM Gopalakrishnan","year":"2015","unstructured":"Gopalakrishnan AM, Kumar N (2015) Antimalarial action of Artesunate involves DNA damage mediated by reactive oxygen species. Antimicrob Agents Chemother 59:317\u2013325","journal-title":"Antimicrob Agents Chemother"},{"key":"4321_CR16","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","volume":"6","author":"A G\u00f6rlach","year":"2015","unstructured":"G\u00f6rlach A, Bertram K, Hudecova S, Krizanova O (2015) Calcium and ROS: A mutual interplay. Redox Biol 6:260\u2013271","journal-title":"Redox Biol"},{"key":"4321_CR17","doi-asserted-by":"publisher","first-page":"112302","DOI":"10.1016\/j.biopha.2021.112302","volume":"144","author":"M Gupta","year":"2021","unstructured":"Gupta M et al (2021a) Inhibition of Heme detoxification pathway in malaria parasite by 3-hydroxy-11-keto-\u03b2-boswellic acid isolated from Boswellia Serrata. Biomed Pharmacother 144:112302","journal-title":"Biomed Pharmacother"},{"key":"4321_CR18","first-page":"06403","volume":"023","author":"D Haghigh","year":"2023","unstructured":"Haghigh D et al (2023) Antiparasitic effects and cellular mechanisms of Formononetin (a natural Isoflavone) against hydatid cyst Protoscoleces. BMC Res Notes 023:06403\u201306401","journal-title":"BMC Res Notes"},{"key":"4321_CR20","doi-asserted-by":"publisher","first-page":"114606","DOI":"10.1016\/j.biopha.2023.114606","volume":"162","author":"AB Jena","year":"2023","unstructured":"Jena AB, Samal RR, Bhol NK, Duttaroy AK (2023) Cellular Red-Ox system in health and disease: the latest update. Biomed Pharmacother 162:114606","journal-title":"Biomed Pharmacother"},{"key":"4321_CR19","doi-asserted-by":"crossref","unstructured":"Jyoti et al (2024) Cu-catalyzed click reaction in synthesis of Eugenol derivatives as potent antimalarial agents. Nat Prod Res. 10.1080.2348670","DOI":"10.1080\/14786419.2024.2348670"},{"key":"4321_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12936-024-04844-y","volume":"23","author":"E Kokori","year":"2024","unstructured":"Kokori E et al (2024) Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts. Malar J 23:25","journal-title":"Malar J"},{"key":"4321_CR22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12936-024-05003-z","volume":"23","author":"KU Kotepui","year":"2024","unstructured":"Kotepui KU et al (2024) Total antioxidant status levels in malaria: a systematic review and meta-analysis. Malar J 23:198","journal-title":"Malar J"},{"key":"4321_CR24","doi-asserted-by":"publisher","first-page":"e10384","DOI":"10.55251\/jmbfs.10384","volume":"13","author":"S Kumar","year":"2024","unstructured":"Kumar S, Mahato RP (2024b) DRUG RESISTANCE AND RESISTANCE REVERSAL STRATEGIES IN MALARIA PARASITE. J Microbiol Biotechnol Food Sci 13:e10384\u2013e10384","journal-title":"J Microbiol Biotechnol Food Sci"},{"key":"4321_CR25","doi-asserted-by":"publisher","first-page":"628970","DOI":"10.3389\/fphar.2021.628970","volume":"12","author":"S Kumar","year":"2021","unstructured":"Kumar S et al (2021) 4-chlorothymol exerts antiplasmodial activity impeding redox defense system in plasmodium falciparum. Front Pharmacol 12:628970","journal-title":"Front Pharmacol"},{"key":"4321_CR23","doi-asserted-by":"crossref","unstructured":"Kumar R et al (2024a) Pharmacology of Manilkara Hexandra leaf extract: potent antimalarial by targeting \u03b2-hematin formation and pro-inflammatory cytokine investigation.1\u201313","DOI":"10.1007\/s42535-024-00930-3"},{"key":"4321_CR26","doi-asserted-by":"publisher","first-page":"100396","DOI":"10.1016\/j.prmcm.2024.100396","volume":"10","author":"S Kumar","year":"2024","unstructured":"Kumar S et al (2024c) Isoliquiritigenin from licorice root: A multi-stage anti-malarial with synergistic impact on multidrug-resistant P. falciparum. Pharmacol Research-Modern Chin Med 10:100396","journal-title":"Pharmacol Research-Modern Chin Med"},{"key":"4321_CR27","doi-asserted-by":"publisher","first-page":"115287","DOI":"10.1016\/j.bcp.2022.115287","volume":"205","author":"J Kumari","year":"2022","unstructured":"Kumari J et al (2022) Erythritol\u2019, a safe natural sweetener exhibits multi-stage anti-malarial activity by permeating into plasmodium falciparum through Aquaglyceroporin channel. Biochem Pharmacol 205:115287","journal-title":"Biochem Pharmacol"},{"key":"4321_CR28","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/jac\/dkp501","volume":"65","author":"T Lauwaet","year":"2010","unstructured":"Lauwaet T, Andersen Y, Van de Ven L, Eckmann L, Gillin FD (2010) Rapid detachment of giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone Formononetin. J Antimicrob Chemother 65:531\u2013534","journal-title":"J Antimicrob Chemother"},{"key":"4321_CR29","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13104-023-06403-1","volume":"16","author":"H Mahmoudvand","year":"2023","unstructured":"Mahmoudvand H, Khalaf AK, Rajabi PZ, Karbasian N, Ghasemian Y (2023) Leishmanicidal and Immunomodulatory activities of the Formononetin (a natural isoflavone) against leishmania tropica. BMC Res Notes 16:120","journal-title":"BMC Res Notes"},{"key":"4321_CR30","doi-asserted-by":"publisher","first-page":"111311","DOI":"10.1016\/j.biopha.2021.111311","volume":"137","author":"PR Mina","year":"2021","unstructured":"Mina PR et al (2021) 4-chloro Eugenol interacts synergistically with Artesunate against drug resistant P. falciparum inducing oxidative stress. Biomed Pharmacother 137:111311","journal-title":"Biomed Pharmacother"},{"key":"4321_CR31","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1080\/14786419.2019.1633650","volume":"35","author":"S Mishra","year":"2021","unstructured":"Mishra S, Kumar S, Darokar MP, Shanker K (2021) Novel bioactive compound from the bark of Putranjiva Roxburghii wall. Nat Prod Res 35:1738\u20131740","journal-title":"Nat Prod Res"},{"key":"4321_CR32","doi-asserted-by":"publisher","first-page":"102675","DOI":"10.1016\/j.parint.2022.102675","volume":"92","author":"S Mishra","year":"2023","unstructured":"Mishra S et al (2023) Quebrachitol from Putranjiva Roxburghii Wall.(Putranjivaceae) a potent antimalarial: Pre-clinical efficacy and its interaction with PfLDH. Parasitol Int 92:102675","journal-title":"Parasitol Int"},{"key":"4321_CR33","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s40164-023-00443-w","volume":"12","author":"S Mittal","year":"2023","unstructured":"Mittal S et al (2023) Preclinical activity of Selinexor in combination with eribulin in uterine leiomyosarcoma. Experimental Hematol Oncol 12:78","journal-title":"Experimental Hematol Oncol"},{"key":"4321_CR34","doi-asserted-by":"publisher","first-page":"104415","DOI":"10.1016\/j.compbiomed.2021.104415","volume":"134","author":"ZT Muhseen","year":"2021","unstructured":"Muhseen ZT, Hameed AR, Al-Bhadly O, Ahmad S, Li G (2021) Natural products for treatment of plasmodium falciparum malaria: an integrated computational approach. Comput Biol Med 134:104415","journal-title":"Comput Biol Med"},{"key":"4321_CR35","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1111\/j.1365-2958.2004.04257.x","volume":"53","author":"S M\u00fcller","year":"2004","unstructured":"M\u00fcller S (2004) Redox and antioxidant systems of the malaria parasite plasmodium falciparum. Mol Microbiol 53:1291\u20131305","journal-title":"Mol Microbiol"},{"key":"4321_CR36","doi-asserted-by":"publisher","first-page":"e804","DOI":"10.1016\/S2542-5196(24)00172-4","volume":"8","author":"RM Oxborough","year":"2024","unstructured":"Oxborough RM, Chilito KCF, Tokponnon F, Messenger LA (2024) Malaria vector control in sub-Saharan Africa: complex trade-offs to combat the growing threat of insecticide resistance. Lancet Planet Health 8:e804\u2013e812","journal-title":"Lancet Planet Health"},{"key":"4321_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2016.02.032","volume":"95","author":"V Pad\u00edn-Irizarry","year":"2016","unstructured":"Pad\u00edn-Irizarry V et al (2016) Glutathione-deficient plasmodium Berghei parasites exhibit growth delay and nuclear DNA damage. Free Radic Biol Med 95:43\u201354","journal-title":"Free Radic Biol Med"},{"key":"4321_CR38","doi-asserted-by":"crossref","unstructured":"Pal C (2023) Redox modulating small molecules having antimalarial efficacy. Biochemical Pharmacology:115927","DOI":"10.1016\/j.bcp.2023.115927"},{"key":"4321_CR39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/antiox13010038","volume":"13","author":"M Paw\u0142owska","year":"2023","unstructured":"Paw\u0142owska M, Mila-Kierzenkowska C, Szczegielniak J, Wo\u017aniak A (2023) Oxidative stress in parasitic diseases\u2014Reactive oxygen species as mediators of interactions between the host and the parasites. Antioxidants 13:38","journal-title":"Antioxidants"},{"key":"4321_CR40","doi-asserted-by":"publisher","first-page":"16346","DOI":"10.3390\/ijms131216346","volume":"13","author":"S Perc\u00e1rio","year":"2012","unstructured":"Perc\u00e1rio S et al (2012) Oxidative stress in malaria. Int J Mol Sci 13:16346\u201316372","journal-title":"Int J Mol Sci"},{"key":"4321_CR41","doi-asserted-by":"publisher","first-page":"118937","DOI":"10.1016\/j.indcrop.2024.118937","volume":"218","author":"F Qamar","year":"2024","unstructured":"Qamar F, Ashrafi K, Singh A, Dash PK, Abdin M (2024) Artemisinin production strategies for industrial scale: current progress and future directions. Ind Crops Prod 218:118937","journal-title":"Ind Crops Prod"},{"key":"4321_CR42","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/nature06384","volume":"450","author":"TA Rapoport","year":"2007","unstructured":"Rapoport TA (2007) Protein translocation across the eukaryotic Endoplasmic reticulum and bacterial plasma membranes. Nature 450:663\u2013669","journal-title":"Nature"},{"key":"4321_CR43","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/fsn3.3784","volume":"12","author":"A Rauf","year":"2024","unstructured":"Rauf A et al (2024) Reactive oxygen species in biological systems: pathways, associated diseases, and potential inhibitors\u2014A review. Food Sci Nutr 12:675\u2013693","journal-title":"Food Sci Nutr"},{"key":"4321_CR44","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1128\/AAC.05012-14","volume":"59","author":"LF Rocha e Silva","year":"2015","unstructured":"Rocha e Silva LF et al (2015) In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives. Antimicrob Agents Chemother 59:3271\u20133280","journal-title":"Antimicrob Agents Chemother"},{"key":"4321_CR45","doi-asserted-by":"crossref","unstructured":"Rosenthal PJ, Asua V, Conrad MD (2024) Emergence, transmission dynamics and mechanisms of Artemisinin partial resistance in malaria parasites in Africa. Nat Rev Microbiol:1\u201312","DOI":"10.1038\/s41579-024-01008-2"},{"key":"4321_CR46","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.3390\/ijms24032914","volume":"24","author":"IP S\u00e6b\u00f8","year":"2023","unstructured":"S\u00e6b\u00f8 IP, Bj\u00f8r\u00e5s M, Franzyk H, Helgesen E, Booth JA (2023) Optimization of the hemolysis assay for the assessment of cytotoxicity. Int J Mol Sci 24:2914","journal-title":"Int J Mol Sci"},{"key":"4321_CR48","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2015.06.016","volume":"87","author":"V Singh","year":"2015","unstructured":"Singh V, Pal A, Darokar MP (2015) A polyphenolic flavonoid glabridin: oxidative stress response in multidrug-resistant Staphylococcus aureus. Free Radic Biol Med 87:48\u201357","journal-title":"Free Radic Biol Med"},{"key":"4321_CR47","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.biopha.2017.02.056","volume":"89","author":"SV Singh","year":"2017","unstructured":"Singh SV et al (2017) Antimalarial activity and safety assessment of flueggea Virosa leaves and its major constituent with special emphasis on their mode of action. Biomed Pharmacother 89:761\u2013771","journal-title":"Biomed Pharmacother"},{"key":"4321_CR49","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ijregi.2024.02.001","volume":"10","author":"DD Sofeu-Feugaing","year":"2024","unstructured":"Sofeu-Feugaing DD et al (2024) Community engagement and antimalarial drugs medication as the first line of defense in the fight against antimalarial drug resistance in some endemic localities in Cameroon. IJID Reg 10:207\u2013213","journal-title":"IJID Reg"},{"key":"4321_CR50","doi-asserted-by":"publisher","first-page":"117339","DOI":"10.1016\/j.bmc.2023.117339","volume":"88","author":"T Umumararungu","year":"2023","unstructured":"Umumararungu T et al (2023) Recent developments in antimalarial drug discovery. Bioorg Med Chem 88:117339","journal-title":"Bioorg Med Chem"},{"key":"4321_CR53","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.tibs.2022.06.011","volume":"48","author":"L Wang","year":"2023","unstructured":"Wang L, Wang C-c (2023) Oxidative protein folding fidelity and redoxtasis in the Endoplasmic reticulum. Trends Biochem Sci 48:40\u201352","journal-title":"Trends Biochem Sci"},{"key":"4321_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12985-015-0264-x","volume":"12","author":"H Wang","year":"2015","unstructured":"Wang H, Zhang D, Ge M, Li Z, Jiang J, Li Y (2015) Formononetin inhibits enterovirus 71 replication by regulating COX-2\/PGE 2 expression. Virol J 12:1\u201310","journal-title":"Virol J"},{"key":"4321_CR52","doi-asserted-by":"publisher","first-page":"5112","DOI":"10.3390\/molecules25215112","volume":"25","author":"J-F Wang","year":"2020","unstructured":"Wang J-F et al (2020) Naturally occurring flavonoids and isoflavonoids and their microbial transformation: A review. Molecules 25:5112","journal-title":"Molecules"},{"key":"4321_CR54","doi-asserted-by":"crossref","unstructured":"Yang Y et al (2008) Synthesis and Biological Evaluation of 7-O\u2010Modified Formononetin Derivatives. Research Letter:209830","DOI":"10.1155\/2008\/209830"},{"key":"4321_CR55","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.3390\/molecules20023389","volume":"20","author":"L Zheng","year":"2015","unstructured":"Zheng L et al (2015) Investigation of chemomarkers of astragali radix of different ages and geographical origin by NMR profiling. Molecules 20:3389\u20133405","journal-title":"Molecules"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04321-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-025-04321-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04321-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T10:07:42Z","timestamp":1747649262000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-025-04321-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["4321"],"URL":"https:\/\/doi.org\/10.1007\/s00203-025-04321-3","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"type":"print","value":"0302-8933"},{"type":"electronic","value":"1432-072X"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"12 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agreed to the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"128"}}