{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:17:08Z","timestamp":1792185428172,"version":"4.4.0"},"reference-count":137,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IIRP-2023-7874"],"award-info":[{"award-number":["IIRP-2023-7874"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00203-025-04371-7","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:25:25Z","timestamp":1750652725000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Understanding the pandemic potential of the avian influenza Virus- key insights into pathogenesis, transmission, and host immunity"],"prefix":"10.1007","volume":"207","author":[{"given":"Muzamil A.","family":"Rather","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muttahir","family":"Aman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amreena","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salik","family":"Nazki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvaiz A.","family":"Koul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Potdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazir A.","family":"Ganai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azmat Alam","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed A.","family":"Chikan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Faizal","family":"Abdul-Careem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Shabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"4371_CR1","doi-asserted-by":"crossref","unstructured":"AbuBakar U, Amrani L, Kamarulzaman FA et al (2023) Avian Influenza Virus Tropism in Humans. Viruses 15","DOI":"10.3390\/v15040833"},{"key":"4371_CR2","doi-asserted-by":"publisher","unstructured":"Alexakis L, Buczkowski H, Ducatez M et al (2025) Avian influenza overview September\u2013December 2024. https:\/\/doi.org\/10.2903\/j.efsa.2025.9204. EFSA Journal 23:","DOI":"10.2903\/j.efsa.2025.9204"},{"key":"4371_CR3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3390\/cells14060418","volume":"14","author":"F Aligolighasemabadi","year":"2025","unstructured":"Aligolighasemabadi F, Bakinowska E, Kie\u0142bowski K et al (2025) Autophagy and respiratory viruses: mechanisms, viral exploitation, and therapeutic insights. Cells 14:418. https:\/\/doi.org\/10.3390\/cells14060418","journal-title":"Cells"},{"key":"4371_CR4","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3390\/pathogens13070561","volume":"13","author":"W An","year":"2024","unstructured":"An W, Lakhina S, Leong J et al (2024) Host innate antiviral response to influenza A virus infection: from viral sensing to antagonism and escape. Pathogens 13:561. https:\/\/doi.org\/10.3390\/pathogens13070561","journal-title":"Pathogens"},{"key":"4371_CR5","doi-asserted-by":"crossref","unstructured":"Atkin-Smith GK, Duan M, Chen W, Poon IKH (2018) The induction and consequences of influenza A virus-induced cell death. Cell Death Dis 9","DOI":"10.1038\/s41419-018-1035-6"},{"key":"4371_CR6","doi-asserted-by":"publisher","unstructured":"Batra J, Tripathi S, Kumar A et al (2016) Human heat shock protein 40 (Hsp40\/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. Sci Rep 6. https:\/\/doi.org\/10.1038\/srep19063","DOI":"10.1038\/srep19063"},{"key":"4371_CR7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-981-99-2820-0_2","volume-title":"Emerging human viral diseases","author":"M Bhalerao Unnati","year":"2023","unstructured":"Bhalerao Unnati M, Anil M, Shivani et al (2023) An updated review on influenza viruses. In: Bhukya Prudhvi, Mhaske Suhas T, Sonkar Subash C (eds) Emerging human viral diseases. Springer, Singapore, pp 71\u2013106"},{"key":"4371_CR8","doi-asserted-by":"publisher","unstructured":"Bi Y, Liu H, Xiong C et al (2016) Novel avian influenza A (H5N6) viruses isolated in migratory waterfowl before the first human case reported in china, 2014. Sci Rep 6. https:\/\/doi.org\/10.1038\/srep29888","DOI":"10.1038\/srep29888"},{"key":"4371_CR9","doi-asserted-by":"crossref","unstructured":"Blagodatski A, Trutneva K, Glazova O et al (2021) Avian influenza in wild birds and poultry: Dissemination pathways, monitoring methods, and virus ecology. Pathogens 10","DOI":"10.3390\/pathogens10050630"},{"key":"4371_CR10","doi-asserted-by":"publisher","unstructured":"Bouvier NM, Palese P (2008) The biology of influenza viruses. Vaccine 26. https:\/\/doi.org\/10.1016\/j.vaccine.2008.07.039","DOI":"10.1016\/j.vaccine.2008.07.039"},{"key":"4371_CR11","unstructured":"Caserta Leonardo F, Elisha B, Salman L et al (2024) Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle. bioRxiv"},{"key":"4371_CR12","unstructured":"CDC (2024a) Highlights in the History of Avian Influenza (Bird Flu) Timeline\u2013 2020\u20132024. In: https:\/\/www.cdc.gov\/flu\/avianflu\/timeline\/avian-timeline-2020s.htm"},{"key":"4371_CR13","unstructured":"CDC (2024b) CDC Confirms New Human Cases of H5 Bird Flu in California. In: https:\/\/www.cdc.gov\/media\/releases\/2024\/s1003-birdflu-case-california.html#:~:text=Including%20this%20most%20recent%20case,)%20and%20California%20(2). Accessed on 04-10-2024"},{"key":"4371_CR14","unstructured":"CDPH (2024) Third Possible Human Case of Bird Flu Detected in California. In: https:\/\/www.cdph.ca.gov\/Programs\/OPA\/Pages\/NR24-030.aspx. Accessed on 07-10-2024"},{"key":"4371_CR15","doi-asserted-by":"crossref","unstructured":"Cesaro T, Michiels T (2021) Inhibition of PKR by viruses. Front Microbiol 12","DOI":"10.3389\/fmicb.2021.757238"},{"key":"4371_CR16","doi-asserted-by":"crossref","unstructured":"Charostad J, Rezaei Zadeh Rukerd M, Mahmoudvand S et al (2023) A comprehensive review of highly pathogenic avian influenza (HPAI) H5N1: an imminent threat at doorstep. Travel Med Infect Dis 55","DOI":"10.1016\/j.tmaid.2023.102638"},{"key":"4371_CR17","doi-asserted-by":"crossref","unstructured":"Chen S, Cheng A, Wang M (2013) Innate sensing of viruses by pattern recognition receptors in birds. Vet Res 44","DOI":"10.1186\/1297-9716-44-82"},{"key":"4371_CR18","doi-asserted-by":"crossref","unstructured":"Chen X, Liu S, Goraya MU et al (2018) Host immune response to influenza A virus infection. Front Immunol 9","DOI":"10.3389\/fimmu.2018.00320"},{"key":"4371_CR19","doi-asserted-by":"publisher","first-page":"105961","DOI":"10.1016\/j.antiviral.2024.105961","volume":"229","author":"D Chen","year":"2024","unstructured":"Chen D, Su W, Choy K-T et al (2024) High throughput profiling identified PA-L106R amino acid substitution in A(H1N1)pdm09 influenza virus that confers reduced susceptibility to Baloxavir in vitro. Antiviral Res 229:105961. https:\/\/doi.org\/10.1016\/j.antiviral.2024.105961","journal-title":"Antiviral Res"},{"key":"4371_CR20","doi-asserted-by":"publisher","unstructured":"Choudhury SM, Ma X, Abdullah SW, Zheng H (2021) Activation and Inhibition of the nlrp3 inflammasome by Rna viruses. J Inflamm Res 14. https:\/\/doi.org\/10.2147\/JIR.S295706","DOI":"10.2147\/JIR.S295706"},{"key":"4371_CR21","doi-asserted-by":"publisher","unstructured":"Chu VC, Whittaker GR (2004) Influenza virus entry and infection require host cell N-linked glycoprotein. Proc Natl Acad Sci U S A 101. https:\/\/doi.org\/10.1073\/pnas.0405172102","DOI":"10.1073\/pnas.0405172102"},{"key":"4371_CR22","doi-asserted-by":"publisher","unstructured":"Clements AL, Peacock TP, Sealy JE et al (2021) PA-X is an avian virulence factor in H9N2 avian influenza virus. J Gen Virol 102. https:\/\/doi.org\/10.1099\/JGV.0.001531","DOI":"10.1099\/JGV.0.001531"},{"key":"4371_CR23","doi-asserted-by":"publisher","unstructured":"Cohen M, Zhang XQ, Senaati HP et al (2013) Influenza A penetrates host mucus by cleaving Sialic acids with neuraminidase. Virol J 10. https:\/\/doi.org\/10.1186\/1743-422X-10-321","DOI":"10.1186\/1743-422X-10-321"},{"key":"4371_CR24","doi-asserted-by":"publisher","unstructured":"Cornelissen JBWJ, Post J, Peeters B et al (2012) Differential innate responses of chickens and ducks to low-pathogenic avian influenza. Avian Pathol 41. https:\/\/doi.org\/10.1080\/03079457.2012.732691","DOI":"10.1080\/03079457.2012.732691"},{"key":"4371_CR25","doi-asserted-by":"crossref","unstructured":"da Costa VG, Saivish MV, Santos DER et al (2020) Comparative epidemiology between the 2009 H1N1 influenza and COVID-19 pandemics. J Infect Public Health 13","DOI":"10.1016\/j.jiph.2020.09.023"},{"key":"4371_CR26","doi-asserted-by":"publisher","unstructured":"Dawood FS, Iuliano AD, Reed C et al (2012) Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: A modelling study. Lancet Infect Dis 12. https:\/\/doi.org\/10.1016\/S1473-3099(12)70121-4","DOI":"10.1016\/S1473-3099(12)70121-4"},{"key":"4371_CR27","doi-asserted-by":"crossref","unstructured":"de Bruin ACM, Funk M, Spronken MI et al (2022) Hemagglutinin subtype specificity and mechanisms of highly pathogenic avian influenza virus genesis. Viruses 14","DOI":"10.3390\/v14071566"},{"key":"4371_CR28","doi-asserted-by":"crossref","unstructured":"Dedola S, Ahmadipour S, de Andrade P et al (2023) Sialic acids in infection and their potential use in detection and protection against pathogens. RSC Chem Biol 5","DOI":"10.1039\/D3CB00155E"},{"key":"4371_CR29","doi-asserted-by":"publisher","unstructured":"Delpont M, Salazar LG, Dewulf J et al (2023) Monitoring biosecurity in poultry production: an overview of databases reporting biosecurity compliance from seven European countries. Front Vet Sci 10. https:\/\/doi.org\/10.3389\/fvets.2023.1231377","DOI":"10.3389\/fvets.2023.1231377"},{"key":"4371_CR30","doi-asserted-by":"crossref","unstructured":"Dey P, Ahuja A, Panwar J et al (2023) Immune control of avian influenza virus infection and its vaccine development. Vaccines (Basel) 11","DOI":"10.3390\/vaccines11030593"},{"key":"4371_CR31","doi-asserted-by":"crossref","unstructured":"Dou D, Revol R, \u00d6stbye H et al (2018) Influenza A virus cell entry, replication, virion assembly and movement. Front Immunol 9","DOI":"10.3389\/fimmu.2018.01581"},{"key":"4371_CR32","doi-asserted-by":"crossref","unstructured":"Du R, Cui Q, Rong L (2019) Competitive Cooperation of hemagglutinin and neuraminidase during influenza a virus entry. Viruses 11","DOI":"10.3390\/v11050458"},{"key":"4371_CR33","doi-asserted-by":"crossref","unstructured":"Duan T, Du Y, Xing C et al (2022) Toll-Like receptor signaling and its role in Cell-Mediated immunity. Front Immunol 13","DOI":"10.3389\/fimmu.2022.812774"},{"key":"4371_CR34","doi-asserted-by":"crossref","unstructured":"Duan C, Li C, Ren R et al (2023) An overview of avian influenza surveillance strategies and modes. Sci One Health 2","DOI":"10.1016\/j.soh.2023.100043"},{"key":"4371_CR35","doi-asserted-by":"publisher","unstructured":"Dzananovic E, McKenna SA, Patel TR (2018) Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review. Biotechnol Genet Eng Rev 34. https:\/\/doi.org\/10.1080\/02648725.2018.1467151","DOI":"10.1080\/02648725.2018.1467151"},{"key":"4371_CR36","unstructured":"ECDC (2024) Avian influenza overview March\u2013June 2024.:text=Between%2013%20March%20and%2020,and%20Mexico%20(one%20fatal%20A(. https:\/\/www.ecdc.europa.eu\/en\/publications-data\/avian-influenza-overview-march-june-2024#:~"},{"key":"4371_CR37","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/antib14010018","volume":"14","author":"M Eriksson","year":"2025","unstructured":"Eriksson M, Larsson A (2025) Avian antibodies as potential therapeutic tools. Antibodies 14:18. https:\/\/doi.org\/10.3390\/antib14010018","journal-title":"Antibodies"},{"key":"4371_CR38","doi-asserted-by":"publisher","unstructured":"Evseev D, Miranzo-Navarro D, Fleming-Canepa X et al (2022) Avian influenza NS1 proteins inhibit human, but not duck, RIG-I ubiquitination and interferon signaling. J Virol 96. https:\/\/doi.org\/10.1128\/jvi.00776-22","DOI":"10.1128\/jvi.00776-22"},{"key":"4371_CR39","doi-asserted-by":"crossref","unstructured":"Farahat RA, Khan SH, Rabaan AA, Al-Tawfiq JA (2023) The resurgence of avian influenza and human infection: A brief outlook. New Microbes New Infect 53","DOI":"10.1016\/j.nmni.2023.101122"},{"key":"4371_CR40","doi-asserted-by":"publisher","unstructured":"Feng W, Sun X, Shi N et al (2017) Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response. Biochem Biophys Res Commun 482. https:\/\/doi.org\/10.1016\/j.bbrc.2016.11.166","DOI":"10.1016\/j.bbrc.2016.11.166"},{"key":"4371_CR41","doi-asserted-by":"publisher","unstructured":"Fereidouni S, Starick E, Karamendin K et al (2023) Genetic characterization of a new candidate hemagglutinin subtype of influenza A viruses. Emerg Microbes Infect 12. https:\/\/doi.org\/10.1080\/22221751.2023.2225645","DOI":"10.1080\/22221751.2023.2225645"},{"key":"4371_CR42","doi-asserted-by":"publisher","unstructured":"Fodor E, Velthuis AJWT (2020) Structure and function of the influenza virus transcription and replication machinery. Cold Spring Harb Perspect Med 10. https:\/\/doi.org\/10.1101\/cshperspect.a038398","DOI":"10.1101\/cshperspect.a038398"},{"key":"4371_CR43","doi-asserted-by":"publisher","unstructured":"Gao Q, Yang C, Ren C et al (2020) Eukaryotic translation elongation factor 1 Delta inhibits the nuclear import of the nucleoprotein and PA-PB1 heterodimer of influenza A virus. J Virol 95. https:\/\/doi.org\/10.1128\/jvi.01391-20","DOI":"10.1128\/jvi.01391-20"},{"key":"4371_CR44","doi-asserted-by":"crossref","unstructured":"Garten W, Braden C, Arendt A et al (2015) Influenza virus activating host proteases: identification, localization and inhibitors as potential therapeutics. Eur J Cell Biol 94","DOI":"10.1016\/j.ejcb.2015.05.013"},{"key":"4371_CR45","doi-asserted-by":"publisher","first-page":"6940","DOI":"10.1038\/s41598-023-33529-w","volume":"13","author":"SM Ghafoori","year":"2023","unstructured":"Ghafoori SM, Petersen GF, Conrady DG et al (2023) Structural characterisation of hemagglutinin from seven influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep 13:6940. https:\/\/doi.org\/10.1038\/s41598-023-33529-w","journal-title":"Sci Rep"},{"key":"4371_CR46","doi-asserted-by":"publisher","unstructured":"G\u00f6tz V, Magar L, Dornfeld D et al (2016) Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import. Sci Rep 6. https:\/\/doi.org\/10.1038\/srep23138","DOI":"10.1038\/srep23138"},{"key":"4371_CR47","doi-asserted-by":"crossref","unstructured":"Graziosi G, Lupini Caterina C, Elena C (2024) Silvia Highly Pathogenic Avian Influenza (HPAI) H5 Clade 2.3.4.4b Virus Infection in Birds and Mammals. animals 14","DOI":"10.20944\/preprints202404.1123.v1"},{"key":"4371_CR48","doi-asserted-by":"crossref","unstructured":"Gu Y, Zuo X, Zhang S et al (2021) The mechanism behind influenza virus cytokine storm. Viruses 13","DOI":"10.3390\/v13071362"},{"key":"4371_CR49","doi-asserted-by":"publisher","unstructured":"Gubareva L, Mohan T (2022) Antivirals targeting the neuraminidase. Cold Spring Harb Perspect Med 12. https:\/\/doi.org\/10.1101\/cshperspect.a038455","DOI":"10.1101\/cshperspect.a038455"},{"key":"4371_CR50","doi-asserted-by":"crossref","unstructured":"Hale BG, Albrecht RA, Garc\u00eda-Sastre A (2010) Innate immune evasion strategies of influenza viruses. Future Microbiol 5","DOI":"10.2217\/fmb.09.108"},{"key":"4371_CR51","doi-asserted-by":"crossref","unstructured":"He J, Kam Y-W (2024) Insights from avian influenza: A review of its multifaceted nature and future pandemic preparedness. Viruses 63","DOI":"10.3390\/v16030458"},{"key":"4371_CR52","doi-asserted-by":"publisher","first-page":"199444","DOI":"10.1016\/j.virusres.2024.199444","volume":"349","author":"L Hohensee","year":"2024","unstructured":"Hohensee L, Scheibner D, Luttermann C et al (2024) PB1-F2 of low pathogenicity H7N7 restricts apoptosis in avian cells. Virus Res 349:199444. https:\/\/doi.org\/10.1016\/j.virusres.2024.199444","journal-title":"Virus Res"},{"key":"4371_CR53","doi-asserted-by":"crossref","unstructured":"Huang G, Huang Q, Wei Y et al (2019) Multiple roles and diverse regulation of the ras\/camp\/protein kinase A pathway in Candida albicans. Mol Microbiol 111","DOI":"10.1111\/mmi.14148"},{"key":"4371_CR54","doi-asserted-by":"crossref","unstructured":"Huang QJ, Kim R, Song K et al (2024) Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography","DOI":"10.1101\/2024.10.15.618557"},{"key":"4371_CR55","doi-asserted-by":"crossref","unstructured":"Husain M (2024) Influenza Virus Host Restriction Factors: The ISGs and Non-ISGs. Pathogens 13","DOI":"10.3390\/pathogens13020127"},{"key":"4371_CR56","doi-asserted-by":"publisher","unstructured":"Islam A, Rahman MZ, Hassan MM et al (2023) Determinants for the presence of avian influenza virus in live bird markets in bangladesh: towards an easy fix of a looming one health issue. One Health 17. https:\/\/doi.org\/10.1016\/j.onehlt.2023.100643","DOI":"10.1016\/j.onehlt.2023.100643"},{"key":"4371_CR57","doi-asserted-by":"publisher","unstructured":"Jester BJ, Uyeki TM, Jernigan DB (2020) Fifty years of influenza A(H3N2) following the pandemic of 1968. Am J Public Health 110. https:\/\/doi.org\/10.2105\/AJPH.2019.305557","DOI":"10.2105\/AJPH.2019.305557"},{"key":"4371_CR58","doi-asserted-by":"crossref","unstructured":"Ji ZX, Wang XQ, Liu XF (2021) NS1: A key protein in the game between influenza A virus and host in innate immunity. Front Cell Infect Microbiol 11","DOI":"10.3389\/fcimb.2021.670177"},{"key":"4371_CR59","doi-asserted-by":"crossref","unstructured":"Kamzeeva PN, Aralov AV, Alferova VA, Korshun VA (2023) Recent advances in molecular mechanisms of nucleoside antivirals. Curr Issues Mol Biol 45","DOI":"10.3390\/cimb45080433"},{"key":"4371_CR60","doi-asserted-by":"crossref","unstructured":"Kapczynski DR, Swayne DE (2009) Influenza vaccines for avian species. Curr Top Microbiol Immunol 333","DOI":"10.1007\/978-3-540-92165-3_6"},{"key":"4371_CR61","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.chom.2024.05.018","volume":"32","author":"U Karakus","year":"2024","unstructured":"Karakus U, Mena I, Kottur J et al (2024) H19 influenza A virus exhibits species-specific MHC class II receptor usage. Cell Host Microbe 32:1089\u20131102e10. https:\/\/doi.org\/10.1016\/j.chom.2024.05.018","journal-title":"Cell Host Microbe"},{"key":"4371_CR62","doi-asserted-by":"publisher","unstructured":"Konstantinova ID, Andronova VL, Fateev IV, Esipov RS (2022) Favipiravir and its structural analogs: antiviral activity and synthesis methods. Acta Naturae 14. https:\/\/doi.org\/10.32607\/actanaturae.11652","DOI":"10.32607\/actanaturae.11652"},{"key":"4371_CR63","doi-asserted-by":"publisher","unstructured":"Koutsakos M, Kedzierska K, Subbarao K (2019) Immune responses to avian influenza viruses. J Immunol 202. https:\/\/doi.org\/10.4049\/jimmunol.1801070","DOI":"10.4049\/jimmunol.1801070"},{"key":"4371_CR64","doi-asserted-by":"crossref","unstructured":"Krammer F (2019) The human antibody response to influenza A virus infection and vaccination. Nat Rev Immunol 19","DOI":"10.1038\/s41577-019-0143-6"},{"key":"4371_CR65","doi-asserted-by":"crossref","unstructured":"Kuchipudi SV, Nelli RK, Gontu A et al (2021) Sialic acid receptors: the key to solving the enigma of zoonotic virus spillover. Viruses 13","DOI":"10.3390\/v13020262"},{"key":"4371_CR66","doi-asserted-by":"publisher","unstructured":"Lai JCC, Karunarathna HMTK, Wong HH et al (2019) Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding. Emerg Microbes Infect 8. https:\/\/doi.org\/10.1080\/22221751.2019.1581034","DOI":"10.1080\/22221751.2019.1581034"},{"key":"4371_CR67","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s42522-024-00127-3","volume":"7","author":"W Leal Filho","year":"2025","unstructured":"Leal Filho W, Nagy GJ, Gbaguidi GJ et al (2025) The role of Climatic changes in the emergence and re-emergence of infectious diseases: bibliometric analysis and literature-supported studies on zoonoses. One Health Outlook 7:12. https:\/\/doi.org\/10.1186\/s42522-024-00127-3","journal-title":"One Health Outlook"},{"key":"4371_CR68","doi-asserted-by":"crossref","unstructured":"Li HC, Yang CH, Lo SY (2022) Strategies of Influenza A Virus to Ensure the Translation of Viral mRNAs. Pathogens 11","DOI":"10.3390\/pathogens11121521"},{"key":"4371_CR69","doi-asserted-by":"publisher","unstructured":"Ling YH, Wang H, Han MQ et al (2022) Nucleoporin 85 interacts with influenza A virus PB1 and PB2 to promote its replication by facilitating nuclear import of ribonucleoprotein. Front Microbiol 13. https:\/\/doi.org\/10.3389\/fmicb.2022.895779","DOI":"10.3389\/fmicb.2022.895779"},{"key":"4371_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.11.226","author":"T Liu","year":"2018","unstructured":"Liu T, Kang M, Zhang B et al (2018) Independent and interactive effects of ambient temperature and absolute humidity on the risks of avian influenza A(H7N9) infection in China. Sci Total Environ. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.11.226. 619\u2013620:","journal-title":"Sci Total Environ"},{"key":"4371_CR71","doi-asserted-by":"publisher","unstructured":"Liu M, Huang LZX, Smits AA et al (2022) Human-type Sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions. Nat Commun 13. https:\/\/doi.org\/10.1038\/s41467-022-31840-0","DOI":"10.1038\/s41467-022-31840-0"},{"key":"4371_CR72","doi-asserted-by":"crossref","unstructured":"Lloren KKS, Lee T, Kwon JJ, Song MS (2017) Molecular markers for interspecies transmission of avian influenza viruses in mammalian hosts. Int J Mol Sci 18","DOI":"10.3390\/ijms18122706"},{"key":"4371_CR73","doi-asserted-by":"crossref","unstructured":"Long JS, Mistry B, Haslam SM, Barclay WS (2019) Host and viral determinants of influenza A virus species specificity. Nat Rev Microbiol 17","DOI":"10.1038\/s41579-018-0115-z"},{"key":"4371_CR74","doi-asserted-by":"crossref","unstructured":"Lu Puxuan Z Qingxia (2015) Highly pathogenic avian influenza. Radiol Infect Dis 1","DOI":"10.1007\/978-94-017-9882-2_18"},{"key":"4371_CR75","doi-asserted-by":"publisher","unstructured":"Luo W, Zhang J, Liang L et al (2018) Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog 14. https:\/\/doi.org\/10.1371\/journal.ppat.1006851","DOI":"10.1371\/journal.ppat.1006851"},{"key":"4371_CR76","doi-asserted-by":"crossref","unstructured":"Ma DY, Suthar MS (2015) Mechanisms of innate immune evasion in re-emerging RNA viruses. Curr Opin Virol 12","DOI":"10.1016\/j.coviro.2015.02.005"},{"key":"4371_CR77","doi-asserted-by":"publisher","unstructured":"M\u00e4nz B, Schwemmle M, Brunotte L (2013) Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J Virol 87. https:\/\/doi.org\/10.1128\/jvi.00980-13","DOI":"10.1128\/jvi.00980-13"},{"key":"4371_CR78","doi-asserted-by":"publisher","unstructured":"Marsili G, Acchioni C, Remoli AL et al (2023) Identification of Anti-Influenza A compounds inhibiting the viral Non-Structural protein 1 (NS1) using a type I Interferon-Driven screening strategy. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/ijms241310495","DOI":"10.3390\/ijms241310495"},{"key":"4371_CR79","doi-asserted-by":"crossref","unstructured":"McKellar J, Rebendenne A, Wencker M et al (2021) Mammalian and avian host cell influenza a restriction factors. Viruses 13","DOI":"10.3390\/v13030522"},{"key":"4371_CR80","doi-asserted-by":"crossref","unstructured":"Moreira EA, Yamauchi Y, Matthias P (2021) How influenza virus uses host cell pathways during uncoating. Cells 10","DOI":"10.3390\/cells10071722"},{"key":"4371_CR81","doi-asserted-by":"publisher","unstructured":"Naito T, Momose F, Kawaguchi A, Nagata K (2007) Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits. J Virol 81. https:\/\/doi.org\/10.1128\/jvi.01917-06","DOI":"10.1128\/jvi.01917-06"},{"key":"4371_CR82","doi-asserted-by":"crossref","unstructured":"Neerukonda SN, Katneni U (2020) Avian pattern recognition receptor sensing and signaling. Vet Sci 7","DOI":"10.3390\/vetsci7010014"},{"key":"4371_CR83","doi-asserted-by":"crossref","unstructured":"Newby ML, Allen JD, Crispin M (2024) Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens. Biotechnol Adv 70","DOI":"10.1016\/j.biotechadv.2023.108283"},{"key":"4371_CR84","doi-asserted-by":"crossref","unstructured":"Ni Zixin W, Jinliang Y, Xiaofei et al (2024) Influenza virus uses mGluR2 as an endocytic receptor to enter cells. Nat Microbiol 9","DOI":"10.1038\/s41564-024-01713-x"},{"key":"4371_CR85","doi-asserted-by":"publisher","unstructured":"Nilsson-Payant BE, Sharps J, Hengrung N, Fodor E (2018) The Surface-Exposed PA 51\u201372 -Loop of the influenza A virus polymerase is required for viral genome replication. J Virol 92. https:\/\/doi.org\/10.1128\/JVI.00687-18","DOI":"10.1128\/JVI.00687-18"},{"key":"4371_CR86","doi-asserted-by":"crossref","unstructured":"Nuwarda RF, Alharbi AA, Kayser V (2021) An overview of influenza viruses and vaccines. Vaccines (Basel) 9","DOI":"10.3390\/vaccines9091032"},{"key":"4371_CR87","doi-asserted-by":"crossref","unstructured":"Peacock T, Moncla L, Dudas G et al (2024) The global H5N1 influenza panzootic in mammals. Nature","DOI":"10.1038\/s41586-024-08054-z"},{"key":"4371_CR88","doi-asserted-by":"crossref","unstructured":"Peukes J, Xiong X, Briggs JAG (2021) New structural insights into the multifunctional influenza A matrix protein 1. FEBS Lett 595","DOI":"10.1002\/1873-3468.14194"},{"key":"4371_CR89","doi-asserted-by":"crossref","unstructured":"Rashid F, Xie Z, Li M et al (2023) Roles and functions of IAV proteins in host immune evasion. Front Immunol 14","DOI":"10.3389\/fimmu.2023.1323560"},{"key":"4371_CR90","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-025-02529-5","author":"MA Rather","year":"2025","unstructured":"Rather MA, Hassan A, Aman M et al (2025) Molecular and ecological determinants of mammalian adaptability in avian influenza virus. Infection. https:\/\/doi.org\/10.1007\/s15010-025-02529-5","journal-title":"Infection"},{"key":"4371_CR91","doi-asserted-by":"crossref","unstructured":"Raut AA, Aasdev A, Kumar N et al (2025) Highly Pathogenic Avian Influenza A (H5N1) Clade 2.3.2.1a virus infection in domestic cats, India, 2025","DOI":"10.1101\/2025.02.23.638954"},{"key":"4371_CR92","doi-asserted-by":"crossref","unstructured":"Rehman S, Effendi MH, Witaningruma AM et al (2023) Avian influenza (H5N1) virus, epidemiology and its effects on backyard poultry in indonesia: a review. F1000Res 11","DOI":"10.12688\/f1000research.125878.2"},{"key":"4371_CR93","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez S, Marandino A, Tom\u00e1s G et al (2024) Infection of South American coatis (Nasua nasua) with highly pathogenic avian influenza H5N1 virus displaying mammalian adaptive mutations. Microb Pathog","DOI":"10.1016\/j.micpath.2024.106895"},{"key":"4371_CR94","doi-asserted-by":"publisher","unstructured":"Ros\u00e1rio-Ferreira N, Preto AJ, Melo R et al (2020) The central role of non-structural protein 1 (NS1) in influenza biology and infection. Int J Mol Sci 21. https:\/\/doi.org\/10.3390\/ijms21041511","DOI":"10.3390\/ijms21041511"},{"key":"4371_CR95","doi-asserted-by":"publisher","unstructured":"Sabsay KR, te Velthuis AJW (2023) Negative and ambisense RNA virus ribonucleocapsids: more than protective armor. Microbiol Mol Biol Rev 87. https:\/\/doi.org\/10.1128\/mmbr.00082-23","DOI":"10.1128\/mmbr.00082-23"},{"key":"4371_CR96","doi-asserted-by":"crossref","unstructured":"Saunders-Hastings PR, Krewski D (2016) Reviewing the history of pandemic influenza: Understanding patterns of emergence and transmission. Pathogens 5","DOI":"10.3390\/pathogens5040066"},{"key":"4371_CR97","doi-asserted-by":"publisher","unstructured":"Schultz-Cherry S, Dybdahl-Sissoko N, Neumann G et al (2001) Influenza virus NS1 protein induces apoptosis in cultured cells. J Virol 75. https:\/\/doi.org\/10.1128\/jvi.75.17.7875-7881.2001","DOI":"10.1128\/jvi.75.17.7875-7881.2001"},{"key":"4371_CR98","doi-asserted-by":"crossref","unstructured":"Sempere Borau M, Stertz S (2021) Entry of influenza A virus into host cells \u2014 recent progress and remaining challenges. Curr Opin Virol 48","DOI":"10.1016\/j.coviro.2021.03.001"},{"key":"4371_CR99","doi-asserted-by":"publisher","first-page":"e1013135","DOI":"10.1371\/journal.ppat.1013135","volume":"21","author":"I Sesifredo","year":"2025","unstructured":"Sesifredo I, Batalha \u00cdL, Amorim MJ (2025) Fast and flu-rious: how to prevent and treat emerging influenza A viruses. PLoS Pathog 21:e1013135. https:\/\/doi.org\/10.1371\/journal.ppat.1013135","journal-title":"PLoS Pathog"},{"key":"4371_CR100","doi-asserted-by":"publisher","unstructured":"Song H, Qi J, Xiao H et al (2017) Avian-to-Human Receptor-Binding adaptation by influenza A virus hemagglutinin H4. Cell Rep 20. https:\/\/doi.org\/10.1016\/j.celrep.2017.07.028","DOI":"10.1016\/j.celrep.2017.07.028"},{"key":"4371_CR101","doi-asserted-by":"crossref","unstructured":"Spronken MI, Funk M, Gultyaev AP et al (2024) Nucleotide sequence as key determinant driving insertions at influenza A virus hemagglutinin cleavage sites. Npj Viruses 2","DOI":"10.1038\/s44298-024-00029-1"},{"key":"4371_CR102","doi-asserted-by":"crossref","unstructured":"Sriwilaijaroen N, Suzuki Y (2020) Host receptors of influenza viruses and coronaviruses\u2014molecular mechanisms of recognition. Vaccines (Basel) 8","DOI":"10.3390\/vaccines8040587"},{"key":"4371_CR103","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000543608","volume":"17","author":"SK Stegeman","year":"2025","unstructured":"Stegeman SK, Kourko O, Amsden H et al (2025) RNA viruses, Toll-Like receptors, and cytokines: the perfect storm?? J Innate Immun 17:126\u2013153. https:\/\/doi.org\/10.1159\/000543608","journal-title":"J Innate Immun"},{"key":"4371_CR104","doi-asserted-by":"publisher","unstructured":"Stimmelmayr R, Rotstein D, Torchetti MK, Gerlach R (2024) Highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b infection in Free-Ranging Polar bear, alaska, USA. Emerg Infect Dis 30. https:\/\/doi.org\/10.3201\/eid3008.240481","DOI":"10.3201\/eid3008.240481"},{"key":"4371_CR105","doi-asserted-by":"crossref","unstructured":"Stokstad E (2024) In Antarctica, scientists track a dangerous bird flu. Science (1979) 383","DOI":"10.1126\/science.adp3271"},{"key":"4371_CR106","doi-asserted-by":"publisher","unstructured":"Sun X, Feng W, Guo Y et al (2018) MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells. J Med Virol 90. https:\/\/doi.org\/10.1002\/jmv.24944","DOI":"10.1002\/jmv.24944"},{"key":"4371_CR107","doi-asserted-by":"crossref","unstructured":"Thompson AJ, Paulson JC (2021) Adaptation of influenza viruses to human airway receptors. J Biol Chem 296","DOI":"10.1074\/jbc.REV120.013309"},{"key":"4371_CR108","doi-asserted-by":"publisher","unstructured":"Thompson D, Cismaru CV, Rougier J-S et al (2023) The M2 proteins of Bat influenza A viruses reveal atypical features compared to conventional M2 proteins. J Virol 97. https:\/\/doi.org\/10.1128\/jvi.00388-23","DOI":"10.1128\/jvi.00388-23"},{"key":"4371_CR109","doi-asserted-by":"crossref","unstructured":"Tiwari Ananda Meril\u00e4inen, P\u00e4ivi L, Erika et al (2024) Avian influenza outbreaks: human infection risks for beach users-One health concern and environmental surveillance implications. Sci Total Environ 943","DOI":"10.1016\/j.scitotenv.2024.173692"},{"key":"4371_CR110","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/vms3.15","volume":"2","author":"PK Turkson","year":"2016","unstructured":"Turkson PK, Okike I (2016) Assessment of practices, capacities and incentives of poultry chain actors in implementation of highly pathogenic avian influenza mitigation measures in Ghana. Vet Med Sci 2:23\u201335. https:\/\/doi.org\/10.1002\/vms3.15","journal-title":"Vet Med Sci"},{"key":"4371_CR111","doi-asserted-by":"crossref","unstructured":"van der Sandt CE, Kreijtz JHCM, Rimmelzwaan GF (2012) Evasion of influenza A viruses from innate and adaptive immune responses. Viruses 4","DOI":"10.3390\/v4091438"},{"key":"4371_CR112","doi-asserted-by":"publisher","unstructured":"Varga ZT, Ramos I, Hai R et al (2011) The influenza virus protein PB1-F2 inhibits the induction of type i interferon at the level of the MAVS adaptor protein. PLoS Pathog 7. https:\/\/doi.org\/10.1371\/journal.ppat.1002067","DOI":"10.1371\/journal.ppat.1002067"},{"key":"4371_CR113","doi-asserted-by":"crossref","unstructured":"Wang Z, Loh L, Kedzierski L, Kedzierska K (2016) Avian influenza viruses, inflammation, and CD8\u2009+\u2009T cell immunity. Front Immunol 7","DOI":"10.3389\/fimmu.2016.00060"},{"key":"4371_CR114","doi-asserted-by":"publisher","unstructured":"Wang R, Zhu Y, Ren C et al (2021) Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy. Autophagy 17. https:\/\/doi.org\/10.1080\/15548627.2020.1725375","DOI":"10.1080\/15548627.2020.1725375"},{"key":"4371_CR115","doi-asserted-by":"publisher","unstructured":"Wang X, Jiang L, Wang G et al (2022) Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin \u03b17 is counteracted by TBK1-p62 axis-mediated autophagy. Cell Mol Immunol 19. https:\/\/doi.org\/10.1038\/s41423-022-00906-w","DOI":"10.1038\/s41423-022-00906-w"},{"key":"4371_CR116","doi-asserted-by":"publisher","unstructured":"Wasberg A, Faria IR, Bergholm J et al (2023) Assessing compatibility and viral fitness between poultry-adapted H9N2 and wild bird-derived neuraminidases. Sci Rep 13. https:\/\/doi.org\/10.1038\/s41598-023-31653-1","DOI":"10.1038\/s41598-023-31653-1"},{"key":"4371_CR117","unstructured":"WHO (2023) Influenza (Seasonal). In: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/influenza-(seasonal). Accessed on 03-09-2024"},{"key":"4371_CR118","unstructured":"WHO 2024 (2024) Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003\u20132024, 28 March 2024. In: https:\/\/www.who.int\/publications\/m\/item\/cumulative-number-of-confirmed-human-cases-for-avian-influenza-a(h5n1)-reported-to-who--2003-2024-28-march-2024"},{"key":"4371_CR119","doi-asserted-by":"crossref","unstructured":"Wong FY, Yaqub T, Zhang R et al (2024) Highly pathogenic avian influenza H5 virus exposure in goats and sheep","DOI":"10.1101\/2024.08.31.610397"},{"key":"4371_CR120","doi-asserted-by":"publisher","unstructured":"Xia C, Vijayan M, Pritzl CJ et al (2016) Hemagglutinin of influenza A virus antagonizes type I interferon (IFN) responses by inducing degradation of type I IFN receptor 1. https:\/\/doi.org\/10.1128\/jvi.02749-15. J Virol 90:","DOI":"10.1128\/jvi.02749-15"},{"key":"4371_CR121","doi-asserted-by":"publisher","unstructured":"Xia C, Wolf JJ, Vijayan M et al (2018) Casein kinase 1\u03b1 mediates the degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus. J Virol 92. https:\/\/doi.org\/10.1128\/jvi.00006-18","DOI":"10.1128\/jvi.00006-18"},{"key":"4371_CR122","doi-asserted-by":"publisher","unstructured":"Xia J, Li YX, Dong MY et al (2023) Evolution of prevalent H9N2 subtype of avian influenza virus during 2019 to 2022 for the development of a control strategy in China. Poult Sci 102. https:\/\/doi.org\/10.1016\/j.psj.2023.102957","DOI":"10.1016\/j.psj.2023.102957"},{"key":"4371_CR123","doi-asserted-by":"publisher","unstructured":"Xie R, Edwards KM, Wille M et al (2023) The episodic resurgence of highly pathogenic avian influenza H5 virus. Nature 622. https:\/\/doi.org\/10.1038\/s41586-023-06631-2","DOI":"10.1038\/s41586-023-06631-2"},{"key":"4371_CR124","doi-asserted-by":"publisher","unstructured":"Xu C, Zhang N, Yang Y et al (2022) Immune escape adaptive mutations in hemagglutinin are responsible for the antigenic drift of Eurasian Avian-Like H1N1 swine influenza viruses. J Virol 96. https:\/\/doi.org\/10.1128\/jvi.00971-22","DOI":"10.1128\/jvi.00971-22"},{"key":"4371_CR125","doi-asserted-by":"publisher","unstructured":"Yang H, Dong Y, Bian Y et al (2022) The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1\/STAT signalling. Nat Commun 13. https:\/\/doi.org\/10.1038\/s41467-022-33909-2","DOI":"10.1038\/s41467-022-33909-2"},{"key":"4371_CR126","doi-asserted-by":"publisher","unstructured":"Yang H, Dong Y, Bian Y et al (2023a) The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice. PLoS Pathog 19. https:\/\/doi.org\/10.1371\/journal.ppat.1011489","DOI":"10.1371\/journal.ppat.1011489"},{"key":"4371_CR127","doi-asserted-by":"crossref","unstructured":"Yang W, Liu X, Wang X (2023b) The immune system of chicken and its response to H9N2 avian influenza virus. Veterinary Q 43","DOI":"10.1080\/01652176.2023.2228360"},{"key":"4371_CR128","doi-asserted-by":"publisher","unstructured":"Yi C, Zhao Z, Wang S et al (2017) Influenza A virus PA antagonizes interferon-\u03b2 by interacting with interferon regulatory factor 3. Front Immunol 8. https:\/\/doi.org\/10.3389\/fimmu.2017.01051","DOI":"10.3389\/fimmu.2017.01051"},{"key":"4371_CR129","doi-asserted-by":"publisher","unstructured":"Zeng Y, Xu S, Wei Y et al (2021) The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation. PLoS Pathog 17. https:\/\/doi.org\/10.1371\/JOURNAL.PPAT.1009300","DOI":"10.1371\/JOURNAL.PPAT.1009300"},{"key":"4371_CR130","doi-asserted-by":"publisher","unstructured":"Zhang B, Liu M, Huang J et al (2022) H1N1 influenza A virus protein NS2 inhibits innate immune response by targeting IRF7. https:\/\/doi.org\/10.3390\/v14112411. Viruses 14:","DOI":"10.3390\/v14112411"},{"key":"4371_CR131","doi-asserted-by":"publisher","unstructured":"Zhang X, Zhang Y, Wei F (2024) Research progress on the nonstructural protein 1 (NS1) of influenza a virus. Virulence 15. https:\/\/doi.org\/10.1080\/21505594.2024.2359470","DOI":"10.1080\/21505594.2024.2359470"},{"key":"4371_CR132","doi-asserted-by":"publisher","unstructured":"Zhang L, Yang Q, Shao Y et al (2025) Influenza A virus NS2 protein acts on vRNA-resident polymerase to drive the transcription to replication switch. Nucleic Acids Res 53. https:\/\/doi.org\/10.1093\/nar\/gkaf027","DOI":"10.1093\/nar\/gkaf027"},{"key":"4371_CR133","doi-asserted-by":"crossref","unstructured":"Zhao C, Pu J (2022) Influence of host Sialic acid receptors structure on the host specificity of influenza viruses. Viruses 14","DOI":"10.3390\/v14102141"},{"key":"4371_CR134","doi-asserted-by":"publisher","unstructured":"Zhao L, Yan Y, Dai Q et al (2020) Development of novel anti-influenza thiazolides with relatively broad-spectrum antiviral potentials. Antimicrob Agents Chemother 64. https:\/\/doi.org\/10.1128\/AAC.00222-20","DOI":"10.1128\/AAC.00222-20"},{"key":"4371_CR135","doi-asserted-by":"publisher","unstructured":"Zhao Y, Huang F, Zou Z et al (2022) Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. Cell Mol Immunol 19. https:\/\/doi.org\/10.1038\/s41423-022-00843-8","DOI":"10.1038\/s41423-022-00843-8"},{"key":"4371_CR136","doi-asserted-by":"publisher","unstructured":"Zhirnov OP, Konakova TE, Wolff T, Klenk H-D (2002) NS1 protein of influenza A virus Down-Regulates apoptosis. J Virol 76. https:\/\/doi.org\/10.1128\/jvi.76.4.1617-1625.2002","DOI":"10.1128\/jvi.76.4.1617-1625.2002"},{"key":"4371_CR137","doi-asserted-by":"crossref","unstructured":"Zhu Z, Fodor E, Keown JR (2023) A structural Understanding of influenza virus genome replication. Trends Microbiol 31","DOI":"10.1016\/j.tim.2022.09.015"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04371-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-025-04371-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04371-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T21:41:48Z","timestamp":1757194908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-025-04371-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":137,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4371"],"URL":"https:\/\/doi.org\/10.1007\/s00203-025-04371-7","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Irfan Gul is employed by Vaxineer Innovations Pvt. Ltd and Naveed Anjum Chikan is employed by Daskdan Innovations Pvt. Ltd. Dr Nadeem Shabir is the director of Poular Biologicals Pvt. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No human participant and\/or animal were used in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"185"}}