{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:31:17Z","timestamp":1787913077011,"version":"build-2784847793"},"reference-count":135,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00203-025-04409-w","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:55:15Z","timestamp":1755590115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Microbial proteases as emerging anti-inflammatory therapeutics: a comprehensive review"],"prefix":"10.1007","volume":"207","author":[{"given":"Amarthya","family":"Suresh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-351X","authenticated-orcid":false,"given":"Mohanasrinivasan","family":"Vaithilingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"1","key":"4409_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12964-023-01337-4","volume":"2023 21:1","author":"A Ahmadi","year":"2023","unstructured":"Ahmadi A, Ahrari S, Salimian J, Salehi Z, Karimi M, Emamvirdizadeh A, Jamalkandi SA, Ghanei M (2023) p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics. Cell Communication Signal 2023 21:1(1):1\u201326. https:\/\/doi.org\/10.1186\/S12964-023-01337-4. 21","journal-title":"Cell Communication Signal"},{"key":"4409_CR2","doi-asserted-by":"publisher","first-page":"133978","DOI":"10.1016\/J.IJBIOMAC.2024.133978","volume":"276","author":"SH Albayati","year":"2024","unstructured":"Albayati SH, Nezhad NG, Taki AG, Rahman RNZRA (2024) Efficient and feasible biocatalysts: strategies for enzyme improvement. A review. Int J Biol Macromol 276:133978\u2013133978. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2024.133978","journal-title":"Int J Biol Macromol"},{"key":"4409_CR3","doi-asserted-by":"publisher","unstructured":"Ali KA, Maity A, Roy SD, Das Pramanik S, Das P, P., Shaharyar MA (2023) Insight into the mechanism of steroidal and non-steroidal anti-inflammatory drugs. In: How synthetic drugs work: insights into molecular pharmacology of classic and new pharmaceuticals. pp. 61\u201394. https:\/\/doi.org\/10.1016\/B978-0-323-99855-0.00004-X","DOI":"10.1016\/B978-0-323-99855-0.00004-X"},{"key":"4409_CR4","doi-asserted-by":"publisher","unstructured":"Aslam AA, Ahmed M, Mughram MHAL, Habib-ur-Rahman Mahmood M, Basheer S, Hussain R, Eiman E, Sanaullah M, Raza H, Saeed A, Hassan M, Iqbal DN (2025) Sulfonamides as a promising scaffold in drug discovery: an insightful review on FDA-approved molecules, synthesis strategy, medical indication, and their binding mode. Chem Biodivers e202403434. https:\/\/doi.org\/10.1002\/CBDV.202403434","DOI":"10.1002\/CBDV.202403434"},{"issue":"6","key":"4409_CR5","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1002\/BAB.2309","volume":"69","author":"NAM Azrin","year":"2022","unstructured":"Azrin NAM, Ali MSM, Rahman RNZRA, Oslan SN, Noor NDM (2022) Versatility of subtilisin: A review on structure, characteristics, and applications. Biotechnol Appl Chem 69(6):2599\u20132616. https:\/\/doi.org\/10.1002\/BAB.2309","journal-title":"Biotechnol Appl Chem"},{"key":"4409_CR6","doi-asserted-by":"publisher","unstructured":"Barahona E, Isidro ES, Sierra-Heras L, \u00c1lvarez-Melc\u00f3n I, Jim\u00e9nez-Vicente E, Buesa JM, Imperial J, Rubio LM (2022) A directed genome evolution method to enhance hydrogen production in Rhodobacter capsulatus. Front Microbiol https:\/\/doi.org\/10.3389\/FMICB.2022.991123","DOI":"10.3389\/FMICB.2022.991123"},{"issue":"7","key":"4409_CR7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41577-019-0147-2","volume":"19","author":"P Baral","year":"2019","unstructured":"Baral P, Udit S, Chiu IM (2019) Pain and immunity: implications for host defence. Nat Reviews Immunol 2019 19:7(7):433\u2013447. https:\/\/doi.org\/10.1038\/s41577-019-0147-2. 19","journal-title":"Nat Reviews Immunol 2019"},{"issue":"1\u20132","key":"4409_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/13543776.2024.2327299","volume":"34","author":"G Barchielli","year":"2024","unstructured":"Barchielli G, Capperucci A, Tanini D (2024) Therapeutic cysteine protease inhibitors: a patent review (2018\u2013present). Expert Opin Ther Pat 34(1\u20132):17\u201349. https:\/\/doi.org\/10.1080\/13543776.2024.2327299","journal-title":"Expert Opin Ther Pat"},{"issue":"1","key":"4409_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/IMMUNO4010002","volume":"4","author":"LL Bastos","year":"2024","unstructured":"Bastos LL, Mariano D, Lemos RP, Bialves TS, Oliveira CJF, de Melo-Minardi RC (2024) The role of structural bioinformatics in Understanding tumor necrosis factor \u03b1-Interacting protein mechanisms in chronic inflammatory diseases: A review. Immuno 2024 4(1):14\u201342. https:\/\/doi.org\/10.3390\/IMMUNO4010002. 4","journal-title":"Immuno 2024"},{"issue":"Supplement1","key":"4409_CR10","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/CDN\/NZAC069.004","volume":"6","author":"S Blecksmith","year":"2022","unstructured":"Blecksmith S, Xue Z, Tang Y, Alkan Z, Stephensen C, Kable M, Lemay D (2022) Carbohydrate active enzyme profiles of gut microbiomes from low and adequate fiber consumers in a healthy U.S. Cohort. Curr Developments Nutr 6(Supplement1):999\u2013999. https:\/\/doi.org\/10.1093\/CDN\/NZAC069.004","journal-title":"Curr Developments Nutr"},{"issue":"1","key":"4409_CR11","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ajhg.2015.05.022","volume":"97","author":"JR Botkin","year":"2015","unstructured":"Botkin JR, Belmont JW, Berg JS, Berkman BE, Bombard Y, Holm IA, Levy HP, Ormond KE, Saal HM, Spinner NB, Wilfond BS, McInerney JD (2015) Points to consider: ethical, legal, and psychosocial implications of genetic testing in children and adolescents. Am J Hum Genet 97(1):6\u201321. https:\/\/doi.org\/10.1016\/j.ajhg.2015.05.022","journal-title":"Am J Hum Genet"},{"issue":"6","key":"4409_CR12","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/S41587-020-00805-3","volume":"39","author":"DSC Butler","year":"2021","unstructured":"Butler DSC, Cafaro C, Putze J, Wan MLY, Tran TH, Ambite I, Ahmadi S, Kjellstr\u00f6m S, Welinder C, Chao SM, Dobrindt U, Svanborg C (2021) A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer. Nat Biotechnol 39(6):754\u2013764. https:\/\/doi.org\/10.1038\/S41587-020-00805-3","journal-title":"Nat Biotechnol"},{"issue":"4","key":"4409_CR13","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.1021\/ACS.JMEDCHEM.0C01140","volume":"65","author":"R Cannalire","year":"2020","unstructured":"Cannalire R, Cerchia C, Beccari AR, Di Leva FS, Summa V (2020) Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the Art and future opportunities. J Med Chem 65(4):2716\u20132746. https:\/\/doi.org\/10.1021\/ACS.JMEDCHEM.0C01140","journal-title":"J Med Chem"},{"issue":"38","key":"4409_CR14","doi-asserted-by":"publisher","first-page":"15598","DOI":"10.1074\/JBC.M117.790865","volume":"292","author":"V Castro-Fernandez","year":"2017","unstructured":"Castro-Fernandez V, Herrera-Morande A, Zamora R, Merino F, Gonzalez-Ordenes F, Padilla-Salinas F, Pereira HM, Brand\u00e3o-Neto J, Garratt RC, Guixe V (2017) Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases. J Biol Chem 292(38):15598\u201315610. https:\/\/doi.org\/10.1074\/JBC.M117.790865","journal-title":"J Biol Chem"},{"issue":"1","key":"4409_CR15","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/PH18010078","volume":"18","author":"L Centanni","year":"2025","unstructured":"Centanni L, Cicerone C, Fanizzi F, D\u2019Amico F, Furfaro F, Zilli A, Parigi TL, Peyrin-Biroulet L, Danese S, Allocca M (2025) Advancing therapeutic targets in IBD: emerging goals and precision medicine approaches. Pharmaceuticals 18(1):78\u201378. https:\/\/doi.org\/10.3390\/PH18010078","journal-title":"Pharmaceuticals"},{"key":"4409_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2022.765744\/PDF","author":"H Ceuleers","year":"2022","unstructured":"Ceuleers H, Hanning N, De bruyn M, De Man JG, De Schepper HU, Li Q, Liu L, Abrams S, Smet A, Joossens J, Augustyns K, De Meester I, Pasricha PJ, De Winter BY (2022) The effect of serine protease inhibitors on visceral pain in different rodent models with an intestinal insult. Front Pharmacol. https:\/\/doi.org\/10.3389\/FPHAR.2022.765744\/PDF","journal-title":"Front Pharmacol"},{"issue":"18","key":"4409_CR17","doi-asserted-by":"publisher","first-page":"8836","DOI":"10.7150\/THNO.63396","volume":"11","author":"H Cheng","year":"2021","unstructured":"Cheng H, Huang H, Guo Z, Chang Y, Li Z (2021) Role of prostaglandin E2 in tissue repair and regeneration. Theranostics 11(18):8836. https:\/\/doi.org\/10.7150\/THNO.63396","journal-title":"Theranostics"},{"key":"4409_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/CBIC.202400564","author":"W Chu","year":"2024","unstructured":"Chu W, Guo Y, Wu Y, Lv X, Li J, Liu L, Du G, Chen J, Liu Y (2024) Enhancing cellular and enzymatic properties through in vivo continuous evolution. ChemBioChem. https:\/\/doi.org\/10.1002\/CBIC.202400564","journal-title":"ChemBioChem"},{"issue":"4","key":"4409_CR19","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/J.CMET.2019.08.003","volume":"30","author":"KW Chung","year":"2019","unstructured":"Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K (2019) Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis. Cell Metabol 30(4):784\u2013799e. https:\/\/doi.org\/10.1016\/J.CMET.2019.08.003","journal-title":"Cell Metabol"},{"key":"4409_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/FCHEM.2022.1025979\/PDF","author":"T Clements-Decker","year":"2022","unstructured":"Clements-Decker T, Kode M, Khan S, Khan W (2022) Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides. Front Chem. https:\/\/doi.org\/10.3389\/FCHEM.2022.1025979\/PDF","journal-title":"Front Chem"},{"issue":"2","key":"4409_CR21","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2174\/0118715257275639231219054353","volume":"22","author":"SB Coutinho","year":"2024","unstructured":"Coutinho SB, Shirodkar RR, Kanjirakkandy A, Arulmozhi V, Vaithilingam M, Chandrasekaran SD (2024) Production of nattokinase from Bacillus amyloliquifaciens MRS18: A bacterial strain isolated from fermented beans. Cardiovasc Hematol Agents Med Chem 22(2):223\u2013229. https:\/\/doi.org\/10.2174\/0118715257275639231219054353","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"issue":"2","key":"4409_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/S00011-018-1208-X","volume":"68:2","author":"M Dadar","year":"2018","unstructured":"Dadar M, Shahali Y, Chakraborty S, Prasad M, Tahoori F, Tiwari R, Dhama K (2018) Antiinflammatory peptides: current knowledge and promising prospects. Inflamm Res 2018 68:2(2):125\u2013145. https:\/\/doi.org\/10.1007\/S00011-018-1208-X. 68","journal-title":"Inflamm Res 2018"},{"key":"4409_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.904881","author":"K Ding","year":"2022","unstructured":"Ding K, Gui Y, Hou X, Ye L, Wang L (2022) Transient receptor potential channels, natriuretic peptides, and angiotensin receptor-neprilysin inhibitors in patients with heart failure. Front Cardiovasc Med. https:\/\/doi.org\/10.3389\/fcvm.2022.904881","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"4409_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S13346-021-01024-2","volume":"12","author":"S \u0110or\u0111evi\u0107","year":"2021","unstructured":"\u0110or\u0111evi\u0107 S, Gonzalez MM, Conejos-S\u00e1nchez I, Carreira B, Pozzi S, Ac\u00farcio RC, Satchi-Fainaro R, Florindo HF, Vicent MJ (2021) Current hurdles to the translation of nanomedicines from bench to the clinic. Drug Delivery Translational Res 12(3):1\u201326. https:\/\/doi.org\/10.1007\/S13346-021-01024-2","journal-title":"Drug Delivery Translational Res"},{"key":"4409_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/S12934-021-01680-6","author":"F Du","year":"2021","unstructured":"Du F, Liu YQ, Xu YS, Li ZJ, Wang YZ, Zhang ZX, Sun XM (2021) Regulating the T7 RNA polymerase expression in E. coli BL21 (DE3) to provide more host options for Recombinant protein production. Microb Cell Fact. https:\/\/doi.org\/10.1186\/S12934-021-01680-6","journal-title":"Microb Cell Fact"},{"issue":"2","key":"4409_CR26","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1136\/flgastro-2019-101323","volume":"12","author":"JA Eccles","year":"2021","unstructured":"Eccles JA, Ascott A, McGeer R, Hills E, Jones SC, Page A, Smith LA, Loewenberger MA, A., Gregory J (2021) Inflammatory bowel disease psychological support pilot reduces inflammatory bowel disease symptoms and improves psychological wellbeing. Frontline Gastroenterol 12(2):154\u2013157. https:\/\/doi.org\/10.1136\/flgastro-2019-101323","journal-title":"Frontline Gastroenterol"},{"issue":"5","key":"4409_CR27","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/S41564-022-01103-1","volume":"7","author":"AL Edwinson","year":"2022","unstructured":"Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Grover M (2022) Gut microbial \u03b2-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome. Nat Microbiol 7(5):680\u2013694. https:\/\/doi.org\/10.1038\/S41564-022-01103-1","journal-title":"Nat Microbiol"},{"issue":"49","key":"4409_CR28","doi-asserted-by":"publisher","first-page":"75086","DOI":"10.1007\/S11356-022-21126-9","volume":"29","author":"MMM Elbakry","year":"2022","unstructured":"Elbakry MMM, Mansour SZ, Helal H, Ahmed ESA (2022) Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats. Environ Sci Pollut Res 29(49):75086\u201375100. https:\/\/doi.org\/10.1007\/S11356-022-21126-9","journal-title":"Environ Sci Pollut Res"},{"key":"4409_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/MINF.202000017","author":"P Ertl","year":"2020","unstructured":"Ertl P, Schuhmann T (2020) Cheminformatics analysis of natural product scaffolds: comparison of scaffolds produced by animals, plants, fungi and bacteria. Mol Inf. https:\/\/doi.org\/10.1002\/MINF.202000017","journal-title":"Mol Inf"},{"issue":"1","key":"4409_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S43094-024-00709-Y","volume":"10","author":"OG Famutimi","year":"2024","unstructured":"Famutimi OG, Adebiyi VG, Akinmolu BG, Dada OV, Adewale IO (2024) Trypsin, chymotrypsin and elastase in health and disease. Future J Pharmaceut Sci. 10(1):1\u201315. https:\/\/doi.org\/10.1186\/S43094-024-00709-Y","journal-title":"Future J Pharmaceut Sci."},{"key":"4409_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/FERMENTATION9110950","author":"M Fang","year":"2023","unstructured":"Fang M, Yuan B, Wang M, Liu J, Wang Z (2023) Nattokinase: insights into biological activity, therapeutic applications, and the influence of microbial fermentation. Fermentation. https:\/\/doi.org\/10.3390\/FERMENTATION9110950","journal-title":"Fermentation"},{"issue":"13","key":"4409_CR32","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.1039\/C6CY00249H","volume":"6","author":"AJ Garcia-Olmo","year":"2016","unstructured":"Garcia-Olmo AJ, Yepez A, Balu AM, Romero AA, Li Y, Luque R (2016) Insights into the activity, selectivity and stability of heterogeneous catalysts in the continuous flow hydroconversion of furfural. Catal Sci Technol 6(13):4705\u20134711. https:\/\/doi.org\/10.1039\/C6CY00249H","journal-title":"Catal Sci Technol"},{"issue":"4","key":"4409_CR33","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41591-025-03615-9","volume":"31","author":"JA Gilbert","year":"2025","unstructured":"Gilbert JA, Azad MB, B\u00e4ckhed F, Blaser MJ, Byndloss M, Chiu CY, Chu H, Dugas LR, Elinav E, Gibbons SM, Gilbert KE, Henn MR, Ishaq SL, Ley RE, Lynch SV, Segal E, Spector TD, Strandwitz P, Suez J, Knight R (2025) Clinical translation of microbiome research. Nat Med 31(4):1099\u20131113. https:\/\/doi.org\/10.1038\/s41591-025-03615-9","journal-title":"Nat Med"},{"key":"4409_CR34","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2024.2416663","author":"M Granito","year":"2024","unstructured":"Granito M, Alvarenga L, Ribeiro M, Carvalhosa P, Andrade T, Mesquita CT, Stockler-Pinto MB, Mafra D, Cardozo LFMF (2024) Nattokinase as an adjuvant therapeutic strategy for non-communicable diseases: a review of fibrinolytic, antithrombotic, anti-inflammatory, and antioxidant effects. Expert Rev Cardiovasc Ther. https:\/\/doi.org\/10.1080\/14779072.2024.2416663","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"4409_CR35","doi-asserted-by":"publisher","DOI":"10.1208\/S12248-023-00852-Z","author":"K Haltaufderhyde","year":"2023","unstructured":"Haltaufderhyde K, Roberts BJ, Khan S, Terry F, Boyle CM, McAllister M, Martin W, Rosenberg A, De Groot AS (2023) Immunoinformatic risk assessment of host cell proteins during process development for biologic therapeutics. Aaps J. https:\/\/doi.org\/10.1208\/S12248-023-00852-Z","journal-title":"Aaps J"},{"issue":"3","key":"4409_CR36","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2174\/1389450122666210809094100\/CITE\/REFWORKS","volume":"23","author":"D Hammers","year":"2021","unstructured":"Hammers D, Carothers K, Lee S (2021) The role of bacterial proteases in microbe and Host-microbe interactions. Curr Drug Targets 23(3):222\u2013239. https:\/\/doi.org\/10.2174\/1389450122666210809094100\/CITE\/REFWORKS","journal-title":"Curr Drug Targets"},{"issue":"10","key":"4409_CR37","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.4014\/jmb.1503.03033","volume":"25","author":"KJ Han","year":"2015","unstructured":"Han KJ, Lee N-K, Park H, Paik H-D (2015) Anticancer and Anti-Inflammatory activity of probiotic Lactococcus lactis NK34. J Microbiol Biotechnol 25(10):1697\u20131701. https:\/\/doi.org\/10.4014\/jmb.1503.03033","journal-title":"J Microbiol Biotechnol"},{"key":"4409_CR38","doi-asserted-by":"publisher","first-page":"134535","DOI":"10.1016\/J.IJBIOMAC.2024.134535","volume":"277","author":"FS Hassan","year":"2024","unstructured":"Hassan FS, El-Fakharany EM, El-Maradny YA, Saleh AK, El-Sayed MH, Mazi W, Omer N, Abdelaziz MA, Jame R, Alatawi IS, El-Gendi H (2024) Comprehensive insight into exploring the potential of microbial enzymes in cancer therapy: progress, challenges, and opportunities: A review. Int J Biol Macromol 277:134535. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2024.134535","journal-title":"Int J Biol Macromol"},{"issue":"5","key":"4409_CR39","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3390\/MICROORGANISMS8050621","volume":"8","author":"J Hrd\u00fd","year":"2020","unstructured":"Hrd\u00fd J, S\u00faken\u00edkov\u00e1 L, Petr\u00e1skov\u00e1 P, Novotn\u00e1 O, Kahoun D, Pet\u0159\u00ed\u010dek M, Chro\u0148\u00e1kov\u00e1 A, Pet\u0159\u00ed\u010dkov\u00e1 K (2020) Inhibition of Pro-Inflammatory cytokines by metabolites of Streptomycetes\u2014A potential alternative to current Anti-Inflammatory drugs?? Microorganisms 8(5):621. https:\/\/doi.org\/10.3390\/MICROORGANISMS8050621","journal-title":"Microorganisms"},{"issue":"10","key":"4409_CR40","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1111\/1753-0407.13439","volume":"15","author":"Z Huang","year":"2023","unstructured":"Huang Z, Chu WK, Ng TK, Chen S, Liang J, Chen CB, Xu Y, Xie B, Ke S, Liu Q, Chen W, Huang D (2023) Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy. J Diabetes 15(10):866\u2013880. https:\/\/doi.org\/10.1111\/1753-0407.13439","journal-title":"J Diabetes"},{"key":"4409_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/FVETS.2021.644325","author":"D Ibrahim","year":"2021","unstructured":"Ibrahim D, Moustafa A, Shahin SE, Sherief WRIA, Abdallah K, Farag MFM, Nassan MA, Ibrahim SM (2021) Impact of fermented or enzymatically fermented dried olive pomace on growth, expression of digestive enzyme and glucose transporter genes, oxidative stability of frozen meat, and economic efficiency of broiler chickens. Front Vet Sci. https:\/\/doi.org\/10.3389\/FVETS.2021.644325","journal-title":"Front Vet Sci"},{"issue":"1","key":"4409_CR42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/10826068.2012.697960","volume":"43","author":"S Ishwarya","year":"2013","unstructured":"Ishwarya S, Sangeetha R (2013) A new serine protease from the leaves of Thespesia populnea. Prep Biochem Biotechnol 43(1):95\u2013107. https:\/\/doi.org\/10.1080\/10826068.2012.697960","journal-title":"Prep Biochem Biotechnol"},{"key":"4409_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00021","author":"A Jablaoui","year":"2020","unstructured":"Jablaoui A, Kriaa A, Mkaouar H, Akermi N, Soussou S, Wysocka M, Wo\u0142oszyn D, Amouri A, Gargouri A, Maguin E, Lesner A, Rhimi M (2020) Fecal serine protease profiling in inflammatory bowel diseases. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2020.00021","journal-title":"Front Cell Infect Microbiol"},{"key":"4409_CR44","doi-asserted-by":"publisher","first-page":"e00544","DOI":"10.1016\/J.BTRE.2020.E00544","volume":"28","author":"SB Jadhav","year":"2020","unstructured":"Jadhav SB, Shah N, Rathi A, Rathi V, Rathi A (2020) Serratiopeptidase: insights into the therapeutic applications. Biotechnol Rep 28:e00544. https:\/\/doi.org\/10.1016\/J.BTRE.2020.E00544","journal-title":"Biotechnol Rep"},{"key":"4409_CR45","doi-asserted-by":"publisher","DOI":"10.1080\/10826068.2024.2364234","author":"GA Jamal","year":"2025","unstructured":"Jamal GA, Jahangirian E, Hamblin MR, Mirzaei H, Tarrahimofrad H, Alikowsarzadeh N (2025) Proteases, a powerful biochemical tool in the service of medicine, clinical and pharmaceutical. Prep Biochem Biotechnol. https:\/\/doi.org\/10.1080\/10826068.2024.2364234","journal-title":"Prep Biochem Biotechnol"},{"key":"4409_CR46","doi-asserted-by":"publisher","first-page":"648472","DOI":"10.3389\/FCELL.2021.648472\/FULL","volume":"9","author":"P Jayaraman","year":"2021","unstructured":"Jayaraman P, Lim R, Ng J, Vemuri MC (2021) Acceleration of translational mesenchymal stromal cell therapy through consistent quality GMP manufacturing. Front Cell Dev Biology 9:648472\u2013648472. https:\/\/doi.org\/10.3389\/FCELL.2021.648472\/FULL","journal-title":"Front Cell Dev Biology"},{"key":"4409_CR47","doi-asserted-by":"publisher","first-page":"3787","DOI":"10.2147\/DDDT.S261283","volume":"14","author":"A Jenab","year":"2020","unstructured":"Jenab A, Roghanian R, Emtiazi G (2020) Bacterial natural compounds with anti-inflammatory and Immunomodulatory properties (Mini review). Drug Des Devel Ther 14:3787\u20133801. https:\/\/doi.org\/10.2147\/DDDT.S261283","journal-title":"Drug Des Devel Ther"},{"key":"4409_CR48","doi-asserted-by":"publisher","DOI":"10.1126\/SCIENCE.ADR6006","author":"K Jiang","year":"2024","unstructured":"Jiang K, Yan Z, Di Bernardo M, Sgrizzi SR, Villiger L, Kayabolen A, Kim BJ, Carscadden JK, Hiraizumi M, Nishimasu H, Gootenberg JS, Abudayyeh OO (2024) Rapid in silico directed evolution by a protein language model with EVOLVEpro. Science. https:\/\/doi.org\/10.1126\/SCIENCE.ADR6006","journal-title":"Science"},{"issue":"1","key":"4409_CR49","doi-asserted-by":"publisher","first-page":"17268","DOI":"10.1038\/S41598-020-74159-W","volume":"10","author":"C Joossen","year":"2020","unstructured":"Joossen C, Ba\u00e1n A, Moreno-Cinos C, Joossens J, Cools N, Lanckacker E, Moons L, Lemmens K, Lambeir AM, Fransen E, Delputte P, Caljon G, Van Der Veken P, Maes L, De Meester I, Kiekens F, Augustyns K, Cos P (2020) A novel Serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation. Sci Rep 10(1):17268. https:\/\/doi.org\/10.1038\/S41598-020-74159-W","journal-title":"Sci Rep"},{"issue":"1","key":"4409_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.26452\/IJPRLS.V11I1.1460","volume":"11","author":"D Jothieswari","year":"2023","unstructured":"Jothieswari D, Srihari MV, Karthik R, Praveen Kumar V, Sumit Giri (2023) Impact of serratiopeptidase on bleeding and clotting time at therapeutic dose. Int J Pharm Res Life Sci 11(1):1\u20134. https:\/\/doi.org\/10.26452\/IJPRLS.V11I1.1460","journal-title":"Int J Pharm Res Life Sci"},{"key":"4409_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/J.SEPPUR.2024.126439","author":"A Jungbauer","year":"2024","unstructured":"Jungbauer A, Satzer P, Duerauer A, Azevedo A, Aires-Barros R, Nilsson B, Farid S, Goldrick S, Ottens M, Sponchioni M, Lahore MF (2024) Continuous downstream processing. Sep Purif Technol. https:\/\/doi.org\/10.1016\/J.SEPPUR.2024.126439","journal-title":"Sep Purif Technol"},{"issue":"3","key":"4409_CR53","doi-asserted-by":"publisher","first-page":"E18715265290911","DOI":"10.2174\/0118715265290911240611072422\/CITE\/REFWORKS","volume":"24","author":"MA Kale","year":"2024","unstructured":"Kale MA, Jain MV (2024) Drug discovery and exploration of heterocycles for the development of Anti-HIV agents. Infect Disord Drug Targets 24(3):E18715265290911. https:\/\/doi.org\/10.2174\/0118715265290911240611072422\/CITE\/REFWORKS","journal-title":"Infect Disord Drug Targets"},{"issue":"6","key":"4409_CR54","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1021\/ACSMEDCHEMLETT.4C00182","volume":"15","author":"RB Kargbo","year":"2024","unstructured":"Kargbo RB (2024) Advances in targeted therapies for inflammatory diseases and cancer: exploring cellular mechanisms and therapeutic strategies. ACS Med Chem Lett 15(6):758\u2013760. https:\/\/doi.org\/10.1021\/ACSMEDCHEMLETT.4C00182","journal-title":"ACS Med Chem Lett"},{"issue":"5","key":"4409_CR55","doi-asserted-by":"publisher","first-page":"278","DOI":"10.5582\/DDT.2021.01094","volume":"15","author":"I Kazama","year":"2021","unstructured":"Kazama I, Senzaki M (2021) Does immunosuppressive property of non-steroidal anti-inflammatory drugs (NSAIDs) reduce COVID-19 vaccine-induced systemic side effects? Drug Discoveries Ther 15(5):278\u2013280. https:\/\/doi.org\/10.5582\/DDT.2021.01094","journal-title":"Drug Discoveries Ther"},{"issue":"11","key":"4409_CR56","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.3390\/MOLECULES26113225","volume":"26","author":"DC Kemp","year":"2021","unstructured":"Kemp DC, Kwon JY (2021) Fish and Shellfish-Derived Anti-Inflammatory protein products: properties and mechanisms. Molecules 26(11):3225. https:\/\/doi.org\/10.3390\/MOLECULES26113225","journal-title":"Molecules"},{"issue":"1","key":"4409_CR57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00109-010-0677-3","volume":"89","author":"K Kessenbrock","year":"2011","unstructured":"Kessenbrock K, Dau T, Jenne DE (2011) Tailor-made inflammation: how neutrophil Serine proteases modulate the inflammatory response. J Mol Med 89(1):23\u201328. https:\/\/doi.org\/10.1007\/s00109-010-0677-3","journal-title":"J Mol Med"},{"key":"4409_CR58","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/J.FREERADBIOMED.2022.04.013","volume":"185","author":"YH Kim","year":"2022","unstructured":"Kim YH, Kim T, Ji KY, Shin IS, Lee JY, Song KH, Kim BY (2022) A time-dependently regulated gene network reveals that Aspergillus protease affects mitochondrial metabolism and airway epithelial cell barrier function via mitochondrial oxidants. Free Radic Biol Med 185:76\u201389. https:\/\/doi.org\/10.1016\/J.FREERADBIOMED.2022.04.013","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"4409_CR59","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/BIOLOGY10040287","volume":"10","author":"YR Kong","year":"2021","unstructured":"Kong YR, Jong YX, Balakrishnan M, Bok ZK, Weng JKK, Tay KC, Goh BH, Ong YS, Chan KG, Lee LH, Khaw KY (2021) Beneficial role of carica Papaya extracts and phytochemicals on oxidative stress and related diseases: A mini review. Biology 10(4):287. https:\/\/doi.org\/10.3390\/BIOLOGY10040287","journal-title":"Biology"},{"issue":"1","key":"4409_CR60","doi-asserted-by":"publisher","first-page":"11494","DOI":"10.1038\/S41598-021-90885-1","volume":"11","author":"C Kropp","year":"2021","unstructured":"Kropp C, Le Corf K, Relizani K, Tambosco K, Martinez C, Chain F, Rawadi G, Langella P, Claus SP, Martin R (2021) The keystone commensal bacterium Christensenella Minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo. Sci Rep 11(1):11494\u201311494. https:\/\/doi.org\/10.1038\/S41598-021-90885-1","journal-title":"Sci Rep"},{"issue":"1","key":"4409_CR61","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1038\/S41598-020-58361-4","volume":"10","author":"CS Kuo","year":"2020","unstructured":"Kuo CS, Chen JS, Lin LY, Schmid-Sch\u00f6nbein GW, Chien S, Huang PH, Chen JW, Lin SJ (2020) Inhibition of Serine protease activity protects against high fat Diet-Induced inflammation and insulin resistance. Sci Rep 10(1):1725. https:\/\/doi.org\/10.1038\/S41598-020-58361-4","journal-title":"Sci Rep"},{"issue":"36","key":"4409_CR62","doi-asserted-by":"publisher","first-page":"9073","DOI":"10.1021\/ACS.LANGMUIR.7B02004","volume":"33","author":"X Lang","year":"2017","unstructured":"Lang X, Zhu L, Gao Y, Wheeldon I (2017) Enhancing enzyme activity and immobilization in nanostructured Inorganic-Enzyme complexes. Langmuir 33(36):9073\u20139080. https:\/\/doi.org\/10.1021\/ACS.LANGMUIR.7B02004","journal-title":"Langmuir"},{"issue":"6","key":"4409_CR63","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3390\/CELLS10061320","volume":"10","author":"C Lechanteur","year":"2021","unstructured":"Lechanteur C, Briquet A, Bettonville V, Baudoux E, Beguin Y (2021) MSC manufacturing for academic clinical trials: from a clinical-Grade to a full GMP-Compliant process. Cells 10(6):1320. https:\/\/doi.org\/10.3390\/CELLS10061320","journal-title":"Cells"},{"key":"4409_CR64","volume-title":"Principles in microbiome engineering","author":"SY Lee","year":"2022","unstructured":"Lee SY, Nielsen J, Stephanopoulos G (2022) Principles in microbiome engineering. Wiley, New York"},{"issue":"12","key":"4409_CR65","doi-asserted-by":"publisher","first-page":"6733","DOI":"10.3390\/IJMS23126733","volume":"23","author":"P Li","year":"2022","unstructured":"Li P, Xu Y, Cao Y, Ding Z (2022) Polypeptides isolated from Lactococcus lactis alleviates lipopolysaccharide (LPS)-Induced inflammation in ctenopharyngodon Idella. Int J Mol Sci 23(12):6733\u20136733. https:\/\/doi.org\/10.3390\/IJMS23126733","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4409_CR66","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1002\/MED.22098","volume":"45","author":"J Liang","year":"2025","unstructured":"Liang J, Tian J, Zhang H, Li H, Chen L (2025) Proteomics: an In-Depth review on recent technical advances and their applications in biomedicine. Med Res Rev 45(4):1021\u20131044. https:\/\/doi.org\/10.1002\/MED.22098","journal-title":"Med Res Rev"},{"issue":"2","key":"4409_CR52","doi-asserted-by":"publisher","first-page":"S628","DOI":"10.1016\/J.AJOG.2023.09.030","volume":"230","author":"K Lithgow","year":"2024","unstructured":"Lithgow K, Dufour A, Sycuro L (2024) Secreted proteases from vaginal prevotella species target and mimic human MMPs and modulate endocervical barrier function. Am J Obstet Gynecol 230(2):S628. https:\/\/doi.org\/10.1016\/J.AJOG.2023.09.030","journal-title":"Am J Obstet Gynecol"},{"key":"4409_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/S11274-024-03957-5","author":"X Liu","year":"2024","unstructured":"Liu X, Lian M, Zhao M, Huang M (2024a) Advances in recombinant protease production: current state and perspectives. World J Microbiol Biotechnol. https:\/\/doi.org\/10.1007\/S11274-024-03957-5","journal-title":"World J Microbiol Biotechnol"},{"key":"4409_CR68","doi-asserted-by":"publisher","first-page":"1507194","DOI":"10.3389\/FPHAR.2024.1507194\/XML\/NLM","volume":"15","author":"Y Liu","year":"2024","unstructured":"Liu Y, Wang C, Li M, Zhu Y, Liu K, Liu Y, Luo M, Zhang C (2024b) Natural ingredients in the regulation of abnormal lipid peroxidation: a potential therapy for pulmonary diseases. Front Pharmacol 15:1507194. https:\/\/doi.org\/10.3389\/FPHAR.2024.1507194\/XML\/NLM","journal-title":"Front Pharmacol"},{"issue":"6","key":"4409_CR69","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/J.CHOM.2025.04.020","volume":"33","author":"X Luo","year":"2025","unstructured":"Luo X, Wang K, Jiang C (2025) Gut microbial enzymes and metabolic dysfunction-associated steatohepatitis: function, mechanism, and therapeutic prospects. Cell Host Microbe 33(6):836\u2013853. https:\/\/doi.org\/10.1016\/J.CHOM.2025.04.020","journal-title":"Cell Host Microbe"},{"key":"4409_CR70","doi-asserted-by":"publisher","DOI":"10.1002\/CBIC.202300194","author":"M Ma","year":"2023","unstructured":"Ma M, Cong Y, Zhang JZH, Zhang L (2023) Cover feature: rational design of a highly specific prolyl endopeptidase to activate the antihypertensive effect of peptides (ChemBioChem 8\/2023). ChemBioChem. https:\/\/doi.org\/10.1002\/CBIC.202300194","journal-title":"ChemBioChem"},{"issue":"8","key":"4409_CR71","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3390\/PR12081571","volume":"12","author":"J Ma","year":"2024","unstructured":"Ma J, Wang L, Chu Y, Wang Y, Chen K, Li H (2024) Recent progress in Non-Aqueous biocatalysis of immobilized enzymes. Processes 2024 12(8):1571. https:\/\/doi.org\/10.3390\/PR12081571. 12","journal-title":"Processes 2024"},{"key":"4409_CR72","doi-asserted-by":"publisher","DOI":"10.1111\/jfpp.14214","author":"M Malik","year":"2019","unstructured":"Malik M, Bora J, Sharma V (2019) Growth studies of potentially probiotic lactic acid bacteria (Lactobacillus plantarum, Lactobacillus acidophilus, and Lactobacillus casei) in carrot and beetroot juice substrates. J Food Process Preserv. https:\/\/doi.org\/10.1111\/jfpp.14214","journal-title":"J Food Process Preserv"},{"issue":"14","key":"4409_CR73","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1021\/acs.jmedchem.7b00723","volume":"60","author":"SMK McKinnie","year":"2017","unstructured":"McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC (2017) Synthetic modification within the RPRL region of Apelin peptides: impact on cardiovascular activity and stability to Neprilysin and plasma degradation. J Med Chem 60(14):6408\u20136427. https:\/\/doi.org\/10.1021\/acs.jmedchem.7b00723","journal-title":"J Med Chem"},{"key":"4409_CR74","doi-asserted-by":"publisher","first-page":"813358","DOI":"10.3389\/FMICB.2022.813358\/EPUB","volume":"13","author":"J Mehta","year":"2022","unstructured":"Mehta J, Rolta R, Mehta BB, Kaushik N, Choi EH, Kaushik NK (2022) Role of dexamethasone and Methylprednisolone corticosteroids in coronavirus disease 2019 hospitalized patients: A review. Front Microbiol 13:813358. https:\/\/doi.org\/10.3389\/FMICB.2022.813358\/EPUB","journal-title":"Front Microbiol"},{"key":"4409_CR75","doi-asserted-by":"publisher","first-page":"528080","DOI":"10.3389\/FONC.2020.00584\/XML\/NLM","volume":"10","author":"MF Mercogliano","year":"2020","unstructured":"Mercogliano MF, Bruni S, Elizalde PV, Schillaci R (2020) Tumor necrosis factor \u03b1 blockade: an opportunity to tackle breast cancer. Front Oncol 10:528080. https:\/\/doi.org\/10.3389\/FONC.2020.00584\/XML\/NLM","journal-title":"Front Oncol"},{"issue":"2","key":"4409_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00207454.2022.2089137","volume":"134","author":"SK Metkar","year":"2022","unstructured":"Metkar SK, Girigoswami A, Bondage DD, Shinde UG, Girigoswami K (2022) The potential of lumbrokinase and serratiopeptidase for the degradation of a\u03b2 1\u201342 peptide\u2014an in vitro and in silico approach. Int J Neurosci 134(2):1\u201313. https:\/\/doi.org\/10.1080\/00207454.2022.2089137","journal-title":"Int J Neurosci"},{"issue":"2","key":"4409_CR77","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/JOF8020109","volume":"8","author":"M Naeem","year":"2022","unstructured":"Naeem M, Manzoor S, Abid MUH, Tareen MBK, Asad M, Mushtaq S, Ehsan N, Amna D, Xu B, Hazafa A (2022) Fungal proteases as emerging biocatalysts to Meet the current challenges and recent developments in biomedical therapies: an updated review. J Fungi 8(2):109. https:\/\/doi.org\/10.3390\/JOF8020109","journal-title":"J Fungi"},{"issue":"10","key":"4409_CR78","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.3390\/BIOM12101468","volume":"12","author":"SR Nair","year":"2022","unstructured":"Nair SR, Devi S., C (2022) Serratiopeptidase: an integrated view of multifaceted therapeutic enzyme. Biomolecules 12(10):1468\u20131468. https:\/\/doi.org\/10.3390\/BIOM12101468","journal-title":"Biomolecules"},{"key":"4409_CR79","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1382816","author":"SR Nair","year":"2024","unstructured":"Nair SR, Devi S (2024) Bioprospecting of serratiopeptidase-producing bacteria from different sources. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2024.1382816","journal-title":"Front Microbiol"},{"key":"4409_CR80","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/J.YMBEN.2024.06.005","volume":"84","author":"O Oftadeh","year":"2024","unstructured":"Oftadeh O, Hatzimanikatis V (2024) Genome-scale models of metabolism and expression predict the metabolic burden of Recombinant protein expression. Metab Eng 84:109\u2013116. https:\/\/doi.org\/10.1016\/J.YMBEN.2024.06.005","journal-title":"Metab Eng"},{"issue":"3","key":"4409_CR81","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nrrheum.2018.17","volume":"14:3","author":"K Oikonomopoulou","year":"2018","unstructured":"Oikonomopoulou K, Diamandis EP, Hollenberg MD, Chandran V (2018) Proteinases and their receptors in inflammatory arthritis: an overview. Nat Reviews Rheumatol 2018 14:3(3):170\u2013180. https:\/\/doi.org\/10.1038\/nrrheum.2018.17. 14","journal-title":"Nat Reviews Rheumatol 2018"},{"issue":"3","key":"4409_CR82","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/S10620-020-06090-Z","volume":"65","author":"A Oka","year":"2020","unstructured":"Oka A, Sartor RB (2020) Microbial-Based and Microbial-Targeted therapies for inflammatory bowel diseases. Dig Dis Sci 65(3):757\u2013788. https:\/\/doi.org\/10.1007\/S10620-020-06090-Z","journal-title":"Dig Dis Sci"},{"key":"4409_CR83","doi-asserted-by":"publisher","DOI":"10.21037\/JLPM-24-2\/COIF","author":"AJ Palmares","year":"2024","unstructured":"Palmares AJ, Clemente B, Pineda-Cortel MR (2024) Exploring the untapped potential: a systematic review of novel enzymes as biomarkers over the past 12 years. J Lab Precision Med. https:\/\/doi.org\/10.21037\/JLPM-24-2\/COIF","journal-title":"J Lab Precision Med"},{"key":"4409_CR84","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/J.BIOCHI.2023.09.011","volume":"218","author":"A Pepe","year":"2023","unstructured":"Pepe A, Tito FR, Guevara MG (2023) Antiplatelet mechanism of a subtilisin-like Serine protease from solanum tuberosum (StSBTc-3). Biochimie 218:152\u2013161. https:\/\/doi.org\/10.1016\/J.BIOCHI.2023.09.011","journal-title":"Biochimie"},{"key":"4409_CR85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121385119","author":"S Popli","year":"2022","unstructured":"Popli S, Chakravarty S, Fan S, Glanz A, Aras S, Nagy LE, Sen GC, Chakravarti R, Chattopadhyay S (2022) IRF3 inhibits nuclear translocation of NF-\u03baB to prevent viral inflammation. Proc Nat Acad Sci. https:\/\/doi.org\/10.1073\/pnas.2121385119","journal-title":"Proc Nat Acad Sci"},{"issue":"1","key":"4409_CR86","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/00005344-199801000-00017","volume":"31","author":"MT Rademaker","year":"1998","unstructured":"Rademaker MT, Charles CJ, Espiner EA, Nicholls MG, Richards AM, Kosoglou T (1998) Combined neutral endopeptidase and angiotensin-Converting enzyme Inhibition in heart failure: role of natriuretic peptides and angiotensin II. J Cardiovasc Pharmacol 31(1):116\u2013125. https:\/\/doi.org\/10.1097\/00005344-199801000-00017","journal-title":"J Cardiovasc Pharmacol"},{"key":"4409_CR87","unstructured":"Rahul G (2025) Anti-inflammatory therapeutics market size, outlook 2035. https:\/\/www.marketresearchfuture.com\/reports\/anti-inflammatory-therapeutics-market-8926"},{"issue":"12 B","key":"4409_CR88","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.47391\/JPMA.1421","volume":"70","author":"MU Raza","year":"2020","unstructured":"Raza MU, Shakeel N, Shakeel R (2020) Serratiopeptidase: A drug without clear benefits. J Pakistan Med Association 70(12 B):2490. https:\/\/doi.org\/10.47391\/JPMA.1421","journal-title":"J Pakistan Med Association"},{"key":"4409_CR89","doi-asserted-by":"publisher","DOI":"10.1242\/DMM.049874","author":"C Richardson","year":"2023","unstructured":"Richardson C, Kelsh RN, Richardson RJ (2023) New advances in CRISPR\/Cas-mediated precise gene-editing techniques. DMM Dis Models Mech https:\/\/doi.org\/10.1242\/DMM.049874","journal-title":"DMM Dis Models Mech"},{"key":"4409_CR90","unstructured":"Roberti A (2024) Targeting NF-\u03baB signaling in macrophages through drug repurposing. 10.5287\/ORA-PRAKZKBEZ"},{"issue":"1","key":"4409_CR91","doi-asserted-by":"publisher","first-page":"2387857","DOI":"10.1080\/19490976.2024.2387857","volume":"16","author":"LE Rondeau","year":"2024","unstructured":"Rondeau LE, Luz D, Santiago BB, Bermudez-Brito A, Hann M, De Palma A, Jury G, Wang J, Verdu X, Galipeau EF, Rolland HJ, Deraison C, Ruf C, Bercik W, Vergnolle P, N., Caminero A (2024) Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2. Gut Microbes 16(1):2387857\u20132387857. https:\/\/doi.org\/10.1080\/19490976.2024.2387857","journal-title":"Gut Microbes"},{"key":"4409_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2019.101162","author":"R Sangeetha","year":"2019","unstructured":"Sangeetha R, Arulpandi I (2019) Anti-inflammatory activity of a serine protease produced from Bacillus pumilus SG2. Biocatal Agric Biotechnol. https:\/\/doi.org\/10.1016\/j.bcab.2019.101162","journal-title":"Biocatal Agric Biotechnol"},{"key":"4409_CR93","doi-asserted-by":"publisher","DOI":"10.1515\/9783111062235-013","author":"R Sathya","year":"2023","unstructured":"Sathya R, Arasu MV, Choi KC, Ilavenil S, Rejiniemon TS, Vijayaraghavan P, Balamuralikrishnan B, Arya P (2023) 13 Perspectives of microbial enzyme biocatalyst in food industries. Microb Oxid Enzymes Biotechnol Appl https:\/\/doi.org\/10.1515\/9783111062235-013","journal-title":"Microb Oxid Enzymes Biotechnol Appl"},{"issue":"4","key":"4409_CR94","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.3390\/MOLECULES27041262","volume":"27","author":"J Savjani","year":"2022","unstructured":"Savjani J, Variya B, Patel S, Mulamkattil S, Amin H, Butani S, Allam A, Ajarem J, Shah H (2022) Drug design, synthesis and biological evaluation of heterocyclic molecules as Anti-Inflammatory agents. Molecules 27(4):1262\u20131262. https:\/\/doi.org\/10.3390\/MOLECULES27041262","journal-title":"Molecules"},{"issue":"22","key":"4409_CR95","doi-asserted-by":"publisher","first-page":"18198","DOI":"10.1021\/ACSSUSCHEMENG.9B04229","volume":"7","author":"A Schievano","year":"2019","unstructured":"Schievano A, Berenguer R, Goglio A, Bocchi S, Marzorati S, Rago L, Louro RO, Paquete CM, Esteve-N\u00fa\u00f1ez A (2019) Electroactive Biochar for Large-Scale environmental applications of microbial electrochemistry. ACS Sustainable Chem Eng 7(22):18198\u201318212. https:\/\/doi.org\/10.1021\/ACSSUSCHEMENG.9B04229","journal-title":"ACS Sustainable Chem Eng"},{"key":"4409_CR96","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.591227","author":"Y Shan","year":"2020","unstructured":"Shan Y, Zhang S, Gao B, Liang S, Zhang H, Yu X, Zhao J, Ye L, Yang Q, Shang W (2020) Adipose tissue SIRT1 regulates insulin sensitizing and anti-inflammatory effects of berberine. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2020.591227","journal-title":"Front Pharmacol"},{"issue":"2","key":"4409_CR97","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/S10989-021-10167-2\/FIGURES\/2","volume":"27","author":"R Shankar","year":"2021","unstructured":"Shankar R, Upadhyay PK, Kumar M (2021) Protease enzymes: highlights on potential of proteases as therapeutics agents. Int J Pept Res Ther 27(2):1281\u20131296. https:\/\/doi.org\/10.1007\/S10989-021-10167-2\/FIGURES\/2","journal-title":"Int J Pept Res Ther"},{"key":"4409_CR98","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.603997","author":"C Sharma","year":"2021","unstructured":"Sharma C, Jha NK, Meeran MFN, Patil CR, Goyal SN, Ojha S (2021) Serratiopeptidase, a serine protease anti-inflammatory, fibrinolytic, and mucolytic drug, can be a useful adjuvant for management in COVID-19. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.603997","journal-title":"Front Pharmacol"},{"issue":"11","key":"4409_CR99","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1039\/D3LC01097J","volume":"24","author":"V Sharma","year":"2024","unstructured":"Sharma V, Mottafegh A, Joo JU, Kang JH, Wang L, Kim DP (2024) Toward microfluidic Continuous-flow and intelligent downstream processing of biopharmaceuticals. Lab Chip 24(11):2861\u20132882. https:\/\/doi.org\/10.1039\/D3LC01097J","journal-title":"Lab Chip"},{"key":"4409_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2021.114791","author":"Y Shen","year":"2022","unstructured":"Shen Y, Teng L, Qu Y, Liu J, Zhu X, Chen S, Yang L, Huang Y, Song Q, Fu Q (2022) Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-\u03baB and MAPK signaling pathways. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/J.JEP.2021.114791","journal-title":"J Ethnopharmacol"},{"key":"4409_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/J.IJBIOMAC.2023.125960","author":"SS Shettar","year":"2023","unstructured":"Shettar SS, Bagewadi ZK, Yaraguppi DA, Das S, Mahanta N, Singh SP, Katti A, Saikia D (2023) Gene expression and molecular characterization of recombinant subtilisin from Bacillus subtilis with antibacterial, antioxidant and anticancer properties. Int J Biol Macromol. https:\/\/doi.org\/10.1016\/J.IJBIOMAC.2023.125960","journal-title":"Int J Biol Macromol"},{"key":"4409_CR102","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02369-20","author":"V Shukla","year":"2021","unstructured":"Shukla V, Phulara SC (2021) Impact of culture condition modulation on the high-yield, high-specificity, and cost-effective production of terpenoids from microbial sources: a review. Appl Environ Microbiol. https:\/\/doi.org\/10.1128\/AEM.02369-20","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"4409_CR103","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/S41573-021-00198-1","volume":"20","author":"O Soehnlein","year":"2021","unstructured":"Soehnlein O, Libby P (2021) Targeting inflammation in atherosclerosis \u2014 from experimental insights to the clinic. Nat Rev Drug Discovery 20(8):589\u2013610. https:\/\/doi.org\/10.1038\/S41573-021-00198-1","journal-title":"Nat Rev Drug Discovery"},{"issue":"11","key":"4409_CR104","doi-asserted-by":"publisher","first-page":"5762","DOI":"10.3390\/IJMS22115762","volume":"22","author":"D Sojka","year":"2021","unstructured":"Sojka D, \u0160nebergerov\u00e1 P, Robbertse L (2021) Protease Inhibition-An established strategy to combat infectious diseases. Int J Mol Sci 22(11):5762. https:\/\/doi.org\/10.3390\/IJMS22115762","journal-title":"Int J Mol Sci"},{"issue":"10","key":"4409_CR105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/S13205-021-02928-Z","volume":"11","author":"P Solanki","year":"2021","unstructured":"Solanki P, Putatunda C, Kumar A, Bhatia R, Walia A (2021) Microbial proteases: ubiquitous enzymes with innumerable uses. 3 Biotech 2021 11(10):1\u201325. https:\/\/doi.org\/10.1007\/S13205-021-02928-Z. 11","journal-title":"3 Biotech 2021"},{"key":"4409_CR106","doi-asserted-by":"publisher","first-page":"1600149","DOI":"10.3389\/FCELL.2025.1600149\/XML\/NLM","volume":"13","author":"AM Soliman","year":"2025","unstructured":"Soliman AM, Soliman M, Shah SSH, Baig HA, Gouda NS, Alenezi BT, Alenezy A, Hegazy AMS, Jan M, Eltom EH (2025) Molecular dynamics of inflammation resolution: therapeutic implications. Front Cell Dev Biology 13:1600149. https:\/\/doi.org\/10.3389\/FCELL.2025.1600149\/XML\/NLM","journal-title":"Front Cell Dev Biology"},{"key":"4409_CR107","doi-asserted-by":"publisher","first-page":"1236368","DOI":"10.3389\/FMICB.2023.1236368","volume":"14","author":"P Song","year":"2023","unstructured":"Song P, Zhang X, Wang S, Xu W, Wang F, Fu R, Wei F (2023a) Microbial proteases and their applications. Front Microbiol 14:1236368. https:\/\/doi.org\/10.3389\/FMICB.2023.1236368","journal-title":"Front Microbiol"},{"key":"4409_CR108","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2023.1129149","author":"Z Song","year":"2023","unstructured":"Song Z, Zhang Q, Wu W, Pu Z, Yu H (2023b) Rational design of enzyme activity and enantioselectivity. Front Bioeng Biotechnol. https:\/\/doi.org\/10.3389\/FBIOE.2023.1129149","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"4409_CR109","doi-asserted-by":"publisher","first-page":"101261","DOI":"10.1016\/j.omtm.2024.101261","volume":"32","author":"D Stone","year":"2024","unstructured":"Stone D, Wang X, Abou-el-Enein M (2024) Biomanufacturing in gene and cell therapy. Mol Therapy - Methods Clin Dev 32(2):101261. https:\/\/doi.org\/10.1016\/j.omtm.2024.101261","journal-title":"Mol Therapy - Methods Clin Dev"},{"key":"4409_CR110","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/J.BIOLOGICALS.2019.12.003","volume":"63","author":"T Suzuki","year":"2020","unstructured":"Suzuki T, Tada M, Ishii-Watabe A (2020) Development of anti-drug monoclonal antibody panels against adalimumab and Infliximab. Biologicals 63:39\u201347. https:\/\/doi.org\/10.1016\/J.BIOLOGICALS.2019.12.003","journal-title":"Biologicals"},{"issue":"4","key":"4409_CR111","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1111\/JVIM.17096","volume":"38","author":"D Szkopek","year":"2024","unstructured":"Szkopek D, Pierzynowski SG, Pierzynowska K, Zaworski K, Kondej A, Wychowa\u0144ski P, Konieczka P, Seklecka B, Donaldson J, Jank M, Woli\u0144ski J (2024) A review: pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals. J Vet Intern Med 38(4):2026\u20132033. https:\/\/doi.org\/10.1111\/JVIM.17096","journal-title":"J Vet Intern Med"},{"issue":"40","key":"4409_CR112","doi-asserted-by":"publisher","first-page":"10323","DOI":"10.1002\/CHEM.202100110","volume":"27","author":"D Teze","year":"2021","unstructured":"Teze D, Zhao J, Wiemann M, Kazi ZGA, Lupo R, Zeuner B, Vuillemin M, R\u00f8nne ME, Carlstr\u00f6m G, Duus J, Sanejouand YH, O\u2019Donohue MJ, Nordberg Karlsson E, Faur\u00e9 R, St\u00e5lbrand H, Svensson B (2021) Rational enzyme design without structural knowledge: A Sequence-Based approach for efficient generation of transglycosylases. Chem---Eur J 27(40):10323\u201310334. https:\/\/doi.org\/10.1002\/CHEM.202100110","journal-title":"Chem- - -Eur J"},{"key":"4409_CR113","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/J.YMBEN.2023.12.003","volume":"81","author":"NB Thal\u00e9n","year":"2023","unstructured":"Thal\u00e9n NB, Barzadd MM, Lundqvist M, Rodhe J, Andersson M, Bidkhori G, Possner D, Su C, Nilsson J, Eisenhut P, Malm M, Karlsson A, Vestin J, Forsberg J, Nordling E, Mardinoglu A, Volk AL, Sandegren A, Rockberg J (2023) Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold. Metab Eng 81:157\u2013166. https:\/\/doi.org\/10.1016\/J.YMBEN.2023.12.003","journal-title":"Metab Eng"},{"key":"4409_CR114","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/B978-0-12-817870-6.00011-0","volume":"3","author":"NG T\u00fcreli","year":"2020","unstructured":"T\u00fcreli NG, T\u00fcreli AE (2020) Upscaling and GMP production of pharmaceutical drug delivery systems. Drug Delivery Trends: 3: Expect Realities Multifunctional Drug Delivery Syst 3:215\u2013229. https:\/\/doi.org\/10.1016\/B978-0-12-817870-6.00011-0","journal-title":"Drug Delivery Trends: 3: Expect Realities Multifunctional Drug Delivery Syst"},{"issue":"1","key":"4409_CR115","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/1751-7915.13987","volume":"15","author":"J van der Oost","year":"2022","unstructured":"van der Oost J (2022) Domestication of proteins \u2013 from evolution to revolution. Microb Biotechnol 15(1):189\u2013190. https:\/\/doi.org\/10.1111\/1751-7915.13987","journal-title":"Microb Biotechnol"},{"issue":"4","key":"4409_CR116","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/S10753-018-0739-1","volume":"41","author":"ML Varela","year":"2018","unstructured":"Varela ML, Mogildea M, Moreno I, Lopes A (2018) Acute inflammation and metabolism. Inflammation 41(4):1115\u20131127. https:\/\/doi.org\/10.1007\/S10753-018-0739-1","journal-title":"Inflammation"},{"issue":"10","key":"4409_CR117","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.3390\/FOODS10102249","volume":"10","author":"C Varilla","year":"2021","unstructured":"Varilla C, Marcone M, Paiva L, Baptista J (2021) Bromelain, a group of pineapple proteolytic complex enzymes (Ananas comosus) and their possible therapeutic and clinical effects. A summary. Foods 10(10):2249. https:\/\/doi.org\/10.3390\/FOODS10102249","journal-title":"Foods"},{"issue":"5","key":"4409_CR118","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/(SICI)1099-1344(199705)39:5<379::AID-JLCR981>3.0.CO;2-I","volume":"39","author":"AJ Villani","year":"1997","unstructured":"Villani AJ, Heys JR (1997) The novel synthesis of the protease inhibitor (S)-1-chloro-3-[(p-tolylsulfonyl)amino]-7-amino-2-[5,5,6,6-3H]heptanone ([3H]TLCK) labeled to high specific activity with tritium. J Label Compd Radiopharm 39(5):379\u2013386","journal-title":"J Label Compd Radiopharm"},{"issue":"06","key":"4409_CR119","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.35629\/4494-090613391344","volume":"09","author":"D Vohra","year":"2024","unstructured":"Vohra D, Agrwal D, Chaudhari DS (2024) The impact of nanotechnology on drug delivery: current trends and future perspectives. Int J Pharm Res Appl 09(06):1339\u20131344. https:\/\/doi.org\/10.35629\/4494-090613391344","journal-title":"Int J Pharm Res Appl"},{"issue":"6","key":"4409_CR120","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/j.drudis.2021.02.018","volume":"26","author":"CT Vong","year":"2021","unstructured":"Vong CT, Tseng HHL, Yao P, Yu H, Wang S, Zhong Z, Wang Y (2021) Specific NLRP3 inflammasome inhibitors: promising therapeutic agents for inflammatory diseases. Drug Discovery Today 26(6):1394\u20131408. https:\/\/doi.org\/10.1016\/j.drudis.2021.02.018","journal-title":"Drug Discovery Today"},{"issue":"8","key":"4409_CR121","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1002\/BIT.28112","volume":"119","author":"F Wang","year":"2022","unstructured":"Wang F, Li X, Swanson M, Guetschow E, Winston M, Smith JP, Hoyt E, Liu Z, Richardson D, Bu X, Jawa V, Variankaval N (2022) Holistic analytical characterization and risk assessment of residual host cell protein impurities in an active pharmaceutical ingredient synthesized by biocatalysts. Biotechnol Bioeng 119(8):2088\u20132104. https:\/\/doi.org\/10.1002\/BIT.28112","journal-title":"Biotechnol Bioeng"},{"issue":"8","key":"4409_CR122","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41578-024-00693-y","volume":"9:8","author":"C Wang","year":"2024","unstructured":"Wang C, Shirzaei Sani E, Shih CD, Lim CT, Wang J, Armstrong DG, Gao W (2024a) Wound management materials and technologies from bench to bedside and beyond. Nat Reviews Mater 2024 9:8(8):550\u2013566. https:\/\/doi.org\/10.1038\/s41578-024-00693-y. 9","journal-title":"Nat Reviews Mater 2024"},{"key":"4409_CR123","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.BIOMAC.4C01179\/ASSET\/IMAGES\/MEDIUM\/BM4C01179_0018.GIF","author":"Y Wang","year":"2024","unstructured":"Wang Y, Liao Y, J. Zhang Y, H. Wu X, Y. Qiao Z, Wang H (2024b) Self-Assembled peptide with morphological structure for bioapplication. Biomacromolecules. https:\/\/doi.org\/10.1021\/ACS.BIOMAC.4C01179\/ASSET\/IMAGES\/MEDIUM\/BM4C01179_0018.GIF","journal-title":"Biomacromolecules"},{"key":"4409_CR124","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3389\/FIMMU.2020.00786\/FULL","volume":"11","author":"K Watson","year":"2020","unstructured":"Watson K, Russell CD, Baillie JK, Dhaliwal K, Fitzgerald JR, Mitchell TJ, Simpson AJ, Renshaw SA, Dockrell DH (2020) Developing novel Host-Based therapies targeting microbicidal responses in macrophages and neutrophils to combat bacterial antimicrobial resistance. Front Immunol 11:786. https:\/\/doi.org\/10.3389\/FIMMU.2020.00786\/FULL","journal-title":"Front Immunol"},{"key":"4409_CR125","doi-asserted-by":"publisher","first-page":"108605","DOI":"10.1016\/J.PHARMTHERA.2024.108605","volume":"256","author":"LM Williams","year":"2024","unstructured":"Williams LM, Cao S (2024) Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches. Pharmacol Ther 256:108605\u2013108605. https:\/\/doi.org\/10.1016\/J.PHARMTHERA.2024.108605","journal-title":"Pharmacol Ther"},{"key":"4409_CR126","doi-asserted-by":"publisher","first-page":"101500","DOI":"10.1016\/j.redox.2020.101500","volume":"32","author":"H Wu","year":"2020","unstructured":"Wu H, Wang Y, Zhang Y, Xu F, Chen J, Duan L, Zhang T, Wang J, Zhang F (2020) Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. Redox Biol 32:101500\u2013101500. https:\/\/doi.org\/10.1016\/j.redox.2020.101500","journal-title":"Redox Biol"},{"key":"4409_CR127","doi-asserted-by":"publisher","DOI":"10.1186\/S40360-021-00506-W","author":"S Xiao","year":"2021","unstructured":"Xiao S, Hu D, Gao Y, Ai Y, Luo S, Chen S, Wang B, Zhou L, Dong Y, Wang Y (2021) Safety assessment of subtilisin QK in rats. BMC Pharmacol Toxicol. https:\/\/doi.org\/10.1186\/S40360-021-00506-W","journal-title":"BMC Pharmacol Toxicol"},{"key":"4409_CR128","doi-asserted-by":"publisher","first-page":"785728","DOI":"10.3389\/FIMMU.2021.785728\/XML\/NLM","volume":"12","author":"Y Xing","year":"2021","unstructured":"Xing Y, Sun X, Dou Y, Wang M, Zhao Y, Yang Q, Zhao Y (2021) The Immuno-Modulation effect of Macrophage-Derived extracellular vesicles in chronic inflammatory diseases. Front Immunol 12:785728. https:\/\/doi.org\/10.3389\/FIMMU.2021.785728\/XML\/NLM","journal-title":"Front Immunol"},{"issue":"3","key":"4409_CR129","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3390\/CIMB45030142","volume":"45","author":"V Yadav","year":"2023","unstructured":"Yadav V, Sharma S, Kumar A, Singh S, Ravichandiran V (2023) Serratiopeptidase attenuates Lipopolysaccharide-Induced vascular inflammation by inhibiting the expression of monocyte chemoattractant Protein-1. Curr Issues Mol Biol 45(3):2201\u20132212. https:\/\/doi.org\/10.3390\/CIMB45030142","journal-title":"Curr Issues Mol Biol"},{"key":"4409_CR130","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/J.JCONREL.2023.08.007","volume":"361","author":"J Yang","year":"2023","unstructured":"Yang J, Li D, Zhang M, Lin G, Hu S, Xu H (2023) From the updated landscape of the emerging biologics for IBDs treatment to the new delivery systems. J Controlled Release 361:568\u2013591. https:\/\/doi.org\/10.1016\/J.JCONREL.2023.08.007","journal-title":"J Controlled Release"},{"issue":"1","key":"4409_CR131","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13568-024-01699-z","volume":"14","author":"S Yang","year":"2024","unstructured":"Yang S, Gui J, Zhang Z, Tang J, Chen S (2024a) Enhancement of doxorubicin production in streptomyces Peucetius by genetic engineering and process optimization. AMB Express 14(1):41. https:\/\/doi.org\/10.1186\/s13568-024-01699-z","journal-title":"AMB Express"},{"key":"4409_CR132","doi-asserted-by":"publisher","DOI":"10.1089\/ARS.2023.0527","author":"XY Yang","year":"2024","unstructured":"Yang XY, Wang SL, Xue WC, Zhang YP, Li LL, Luo ZH, Zhang FJ (2024b) Nattokinase\u2019s neuroprotective mechanisms in ischemic stroke: targeting inflammation, oxidative stress, and coagulation. Antioxid Redox Signal. https:\/\/doi.org\/10.1089\/ARS.2023.0527","journal-title":"Antioxid Redox Signal"},{"key":"4409_CR133","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHRS.2021.105861","author":"M Zhang","year":"2022","unstructured":"Zhang M, Xu N, Xu W, Ling G, Zhang P (2022) Potential therapies and diagnosis based on Golgi-targeted nano drug delivery systems. Pharmacol Res. https:\/\/doi.org\/10.1016\/J.PHRS.2021.105861","journal-title":"Pharmacol Res"},{"key":"4409_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOTECHADV.2024.108376","author":"L Zhou","year":"2024","unstructured":"Zhou L, Tao C, Shen X, Sun X, Wang J, Yuan Q (2024) Unlocking the potential of enzyme engineering via rational computational design strategies. Biotechnol Adv. https:\/\/doi.org\/10.1016\/J.BIOTECHADV.2024.108376","journal-title":"Biotechnol Adv"},{"issue":"8","key":"4409_CR135","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1016\/J.CHEMPR.2024.07.007","volume":"10","author":"Z Zou","year":"2024","unstructured":"Zou Z, Higginson B, Ward TR (2024) Creation and optimization of artificial metalloenzymes: Harnessing the power of directed evolution and beyond. CheM 10(8):2373\u20132389. https:\/\/doi.org\/10.1016\/J.CHEMPR.2024.07.007","journal-title":"CheM"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04409-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-025-04409-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04409-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T16:55:24Z","timestamp":1757436924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-025-04409-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":135,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4409"],"URL":"https:\/\/doi.org\/10.1007\/s00203-025-04409-w","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"30 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"I hereby give my consent for the publication of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"229"}}