{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:58Z","timestamp":1791495178739,"version":"4.3.4"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/003585"],"award-info":[{"award-number":["CRG\/2021\/003585"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IIRP23\/4057"],"award-info":[{"award-number":["IIRP23\/4057"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00203-025-04414-z","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T12:13:05Z","timestamp":1753963985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insights into the evolution of Candidalysin and recent developments"],"prefix":"10.1007","volume":"207","author":[{"given":"Ananya","family":"Konwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartavya","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjan","family":"Bhorali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Puria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"issue":"2","key":"4414_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1128\/CMR.00076-09","volume":"23","author":"JM Achkar","year":"2010","unstructured":"Achkar JM, Fries BC (2010) Candida infections of the genitourinary tract. Clin Microbiol Rev 23(2):253\u2013273. https:\/\/doi.org\/10.1128\/CMR.00076-09","journal-title":"Clin Microbiol Rev"},{"issue":"48","key":"4414_CR2","doi-asserted-by":"publisher","first-page":"eaba0570","DOI":"10.1126\/sciimmunol.aba0570","volume":"5","author":"FEY Aggor","year":"2020","unstructured":"Aggor FEY, Break TJ, Trevejo-Nu\u00f1ez G, Whibley N, Coleman BM, Bailey RD, Kaplan DH, Naglik JR, Shan W, Shetty AC, McCracken C, Durum SK, Biswas PS, Bruno VM, Kolls JK, Lionakis MS, Gaffen SL (2020) Oral epithelial IL-22\/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis. Sci Immunol 5(48):eaba0570. https:\/\/doi.org\/10.1126\/sciimmunol.aba0570","journal-title":"Sci Immunol"},{"key":"4414_CR3","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1471-2180-8-116","volume":"8","author":"O Bader","year":"2008","unstructured":"Bader O, Krauke Y, Hube B (2008) Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris. BMC Microbiol 8:116. https:\/\/doi.org\/10.1186\/1471-2180-8-116","journal-title":"BMC Microbiol"},{"issue":"18","key":"4414_CR4","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1128\/jb.178.18.5353-5360.1996","volume":"178","author":"DA Bailey","year":"1996","unstructured":"Bailey DA, Feldmann PJ, Bovey M, Gow NA, Brown AJ (1996) The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins. J Bacteriol 178(18):5353\u20135360. https:\/\/doi.org\/10.1128\/jb.178.18.5353-5360.1996","journal-title":"J Bacteriol"},{"issue":"W1","key":"4414_CR5","doi-asserted-by":"publisher","first-page":"W39","DOI":"10.1093\/nar\/gkv416","volume":"43","author":"TL Bailey","year":"2015","unstructured":"Bailey TL, Johnson J, Grant CE, Noble WS (2015) The MEME suite. Nucleic Acids Res 43(W1):W39\u2013W49. https:\/\/doi.org\/10.1093\/nar\/gkv416","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"4414_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s002329900201","volume":"156","author":"B Bechinger","year":"1997","unstructured":"Bechinger B (1997) Structure and functions of channel-forming peptides: magainins, cecropins, Melittin and alamethicin. J Membr Biol 156(3):197\u2013211. https:\/\/doi.org\/10.1007\/s002329900201","journal-title":"J Membr Biol"},{"key":"4414_CR8","doi-asserted-by":"publisher","unstructured":"Biswas B, Rana A, Gupta N, Gupta I, Puria R, Thakur A (2023) A novel robust method mimicking human substratum to dissect the heterogeneity of Candida auris biofilm formation. Microbiol Spectr 11(4). https:\/\/doi.org\/10.1128\/spectrum.00892-23","DOI":"10.1128\/spectrum.00892-23"},{"issue":"1","key":"4414_CR7","doi-asserted-by":"publisher","first-page":"e5146","DOI":"10.21769\/BioProtoc.5146","volume":"15","author":"B Biswas","year":"2025","unstructured":"Biswas B, Asif S, Puria R, Thakur A (2025) A novel and robust method for investigating fungal biofilm. Bio-Protocol 15(1):e5146. https:\/\/doi.org\/10.21769\/BioProtoc.5146","journal-title":"Bio-Protocol"},{"issue":"3","key":"4414_CR9","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1128\/JCM.02816-12","volume":"51","author":"AM Borman","year":"2013","unstructured":"Borman AM, Szekely A, Linton CJ, Palmer MD, Brown P, Johnson EM (2013) Epidemiology, antifungal susceptibility, and pathogenicity of Candida Africana isolates from the united Kingdom. J Clin Microbiol 51(3):967\u2013972. https:\/\/doi.org\/10.1128\/JCM.02816-12","journal-title":"J Clin Microbiol"},{"issue":"1","key":"4414_CR10","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1371\/journal.pgen.0010001","volume":"1","author":"BR Braun","year":"2005","unstructured":"Braun BR, Hoog M, van het, d\u2019Enfert C, Martchenko M, Dungan J, Kuo A, Inglis DO, Uhl MA, Hogues H, Berriman M, Lorenz M, Levitin A, Oberholzer U, Bachewich C, Harcus D, Marcil A, Dignard D, Iouk T, Zito R, Nantel A (2005) A Human-Curated annotation of the Candida albicans genome. PLoS Genet 1(1):e1. https:\/\/doi.org\/10.1371\/journal.pgen.0010001","journal-title":"PLoS Genet"},{"issue":"1","key":"4414_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nri1745","volume":"6","author":"GD Brown","year":"2006","unstructured":"Brown GD (2006) Dectin-1: A signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 6(1):33\u201343. https:\/\/doi.org\/10.1038\/nri1745","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"4414_CR12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1128\/MMBR.00032-07","volume":"72","author":"WL Chaffin","year":"2008","unstructured":"Chaffin WL (2008) Candida albicans cell wall proteins. Microbiol Mol Biology Reviews: MMBR 72(3):495\u2013544. https:\/\/doi.org\/10.1128\/MMBR.00032-07","journal-title":"Microbiol Mol Biology Reviews: MMBR"},{"issue":"3","key":"4414_CR13","doi-asserted-by":"publisher","first-page":"001447","DOI":"10.1099\/mic.0.001447","volume":"170","author":"M Ch\u00e1vez-Tinoco","year":"2024","unstructured":"Ch\u00e1vez-Tinoco M, Garc\u00eda-Ortega LF, Mancera E (2024) Genetic modification of Candida maltosa, a non-pathogenic CTG species, reveals EFG1 function. Microbiology 170(3):001447. https:\/\/doi.org\/10.1099\/mic.0.001447","journal-title":"Microbiology"},{"key":"4414_CR14","doi-asserted-by":"publisher","unstructured":"Choi J, Kim S-H (2017) A genome Tree of Life for the Fungi kingdom. Proceedings of the National Academy of Sciences, 114(35), 9391\u20139396. https:\/\/doi.org\/10.1073\/pnas.1711939114","DOI":"10.1073\/pnas.1711939114"},{"issue":"1","key":"4414_CR15","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/sj.bjc.6604794","volume":"100","author":"M Colomiere","year":"2009","unstructured":"Colomiere M, Ward AC, Riley C, Trenerry MK, Cameron-Smith D, Findlay J, Ackland L, Ahmed N (2009) Cross talk of signals between EGFR and IL-6R through JAK2\/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br J Cancer 100(1):134\u2013144. https:\/\/doi.org\/10.1038\/sj.bjc.6604794","journal-title":"Br J Cancer"},{"issue":"2","key":"4414_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1084\/jem.20081463","volume":"206","author":"HR Conti","year":"2009","unstructured":"Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, Hai JH, Yu JJ, Jung JW, Filler SG, Masso-Welch P, Edgerton M, Gaffen SL (2009) Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206(2):299\u2013311. https:\/\/doi.org\/10.1084\/jem.20081463","journal-title":"J Exp Med"},{"issue":"10","key":"4414_CR16","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1084\/jem.20130877","volume":"211","author":"HR Conti","year":"2014","unstructured":"Conti HR, Peterson AC, Brane L, Huppler AR, Hern\u00e1ndez-Santos N, Whibley N, Garg AV, Simpson-Abelson MR, Gibson GA, Mamo AJ, Osborne LC, Bishu S, Ghilardi N, Siebenlist U, Watkins SC, Artis D, McGeachy MJ, Gaffen SL (2014) Oral-resident natural Th17 cells and \u03b3\u03b4 T cells control opportunistic Candida albicans infections. J Exp Med 211(10):2075\u20132084. https:\/\/doi.org\/10.1084\/jem.20130877","journal-title":"J Exp Med"},{"issue":"5427","key":"4414_CR18","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1126\/science.285.5427.578","volume":"285","author":"BP Cormack","year":"1999","unstructured":"Cormack BP, Ghori N, Falkow S (1999) An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Sci (New York N Y) 285(5427):578\u2013582. https:\/\/doi.org\/10.1126\/science.285.5427.578","journal-title":"Sci (New York N Y)"},{"issue":"11","key":"4414_CR19","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1128\/IAI.00248-10","volume":"78","author":"A Correia","year":"2010","unstructured":"Correia A, Lermann U, Teixeira L, Cerca F, Botelho S, da Costa RMG, Sampaio P, G\u00e4rtner F, Morschh\u00e4user J, Vilanova M, Pais C (2010) Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis. Infect Immun 78(11):4839\u20134849. https:\/\/doi.org\/10.1128\/IAI.00248-10","journal-title":"Infect Immun"},{"issue":"3","key":"4414_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/mmi.12918","volume":"96","author":"N Cumby","year":"2015","unstructured":"Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL (2015) The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of. Coli phage HK97. Mol Microbiol 96(3):437\u2013447. https:\/\/doi.org\/10.1111\/mmi.12918","journal-title":"Mol Microbiol"},{"key":"4414_CR21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.micpath.2018.02.028","volume":"117","author":"M Dadar","year":"2018","unstructured":"Dadar M, Tiwari R, Karthik K, Chakraborty S, Shahali Y, Dhama K (2018) Candida albicans\u2014Biology, molecular characterization, pathogenicity, and advances in diagnosis and control\u2013 An update. Microb Pathog 117:128\u2013138. https:\/\/doi.org\/10.1016\/j.micpath.2018.02.028","journal-title":"Microb Pathog"},{"issue":"4","key":"4414_CR22","doi-asserted-by":"publisher","first-page":"e1002585","DOI":"10.1371\/journal.ppat.1002585","volume":"8","author":"S Fanning","year":"2012","unstructured":"Fanning S, Mitchell AP (2012) Fungal biofilms. PLoS Pathog 8(4):e1002585. https:\/\/doi.org\/10.1371\/journal.ppat.1002585","journal-title":"PLoS Pathog"},{"key":"4414_CR23","doi-asserted-by":"publisher","unstructured":"Fey A, Tj B, Bm GT-NNW, Rd C, Dh B, Jr K, Ac NWS, Sk SCM, Ps D, Vm B, Jk B, Ms K, L., Sl G (2020) Oral epithelial IL-22\/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis. Sci Immunol 5(48). https:\/\/doi.org\/10.1126\/sciimmunol.aba0570","DOI":"10.1126\/sciimmunol.aba0570"},{"issue":"2","key":"4414_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrmicro2711","volume":"10","author":"NAR Gow","year":"2012","unstructured":"Gow NAR, Van De Veerdonk FL, Brown AJP, Netea MG (2012) Candida albicans morphogenesis and host defence: discriminating invasion from colonization. Nat Rev Microbiol 10(2):112\u2013122. https:\/\/doi.org\/10.1038\/nrmicro2711","journal-title":"Nat Rev Microbiol"},{"issue":"11","key":"4414_CR25","doi-asserted-by":"publisher","first-page":"e1001193","DOI":"10.1371\/journal.ppat.1001193","volume":"6","author":"RA Hall","year":"2010","unstructured":"Hall RA, Sordi LD, MacCallum DM, Topal H, Eaton R, Bloor JW, Robinson GK, Levin LR, Buck J, Wang Y, Gow NAR, Steegborn C, M\u00fchlschlegel FA (2010) CO2 acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog 6(11):e1001193. https:\/\/doi.org\/10.1371\/journal.ppat.1001193","journal-title":"PLoS Pathog"},{"key":"4414_CR26","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.08.487609","author":"J Hallgren","year":"2022","unstructured":"Hallgren J, Tsirigos KD, Pedersen MD, Almagro Armenteros JJ, Marcatili P, Nielsen H, Krogh A, Winther O (2022) DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks. Cold Spring Harbor Lab. https:\/\/doi.org\/10.1101\/2022.04.08.487609","journal-title":"Cold Spring Harbor Lab"},{"issue":"12","key":"4414_CR27","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1017\/S0953756201004725","volume":"105","author":"DL Hawksworth","year":"2001","unstructured":"Hawksworth DL (2001) The magnitude of fungal diversity: the 1.5 million species estimate revisited*. Mycol Res 105(12):1422\u20131432. https:\/\/doi.org\/10.1017\/S0953756201004725","journal-title":"Mycol Res"},{"issue":"1","key":"4414_CR28","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1038\/s41467-019-09915-2","volume":"10","author":"J Ho","year":"2019","unstructured":"Ho J, Yang X, Nikou S-A, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C, Henley-Smith R, Thavaraj S, Tynan CJ, Gaffen SL, Hube B, Wheeler RT, Moyes DL, Naglik JR (2019) Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nat Commun 10(1):2297. https:\/\/doi.org\/10.1038\/s41467-019-09915-2","journal-title":"Nat Commun"},{"issue":"12","key":"4414_CR29","doi-asserted-by":"publisher","first-page":"e1011843","DOI":"10.1371\/journal.ppat.1011843","volume":"19","author":"MV Horton","year":"2023","unstructured":"Horton MV, Holt AM, Nett JE (2023) Mechanisms of pathogenicity for the emerging fungus Candida auris. PLoS Pathog 19(12):e1011843. https:\/\/doi.org\/10.1371\/journal.ppat.1011843","journal-title":"PLoS Pathog"},{"issue":"6","key":"4414_CR30","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s002940050359","volume":"33","author":"LL Hoyer","year":"1998","unstructured":"Hoyer LL, Payne TL, Bell M, Myers AM, Scherer S (1998) Candida albicans ALS3 and insights into the nature of the ALS gene family. Curr Genet 33(6):451\u2013459. https:\/\/doi.org\/10.1007\/s002940050359","journal-title":"Curr Genet"},{"issue":"6","key":"4414_CR31","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.chom.2008.05.003","volume":"3","author":"KJ Ishii","year":"2008","unstructured":"Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S (2008) Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe 3(6):352\u2013363. https:\/\/doi.org\/10.1016\/j.chom.2008.05.003","journal-title":"Cell Host Microbe"},{"key":"4414_CR32","doi-asserted-by":"publisher","unstructured":"Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S (2004) The diploid genome sequence of Candida albicans. Proceedings of the National Academy of Sciences, 101(19), 7329\u20137334. https:\/\/doi.org\/10.1073\/pnas.0401648101","DOI":"10.1073\/pnas.0401648101"},{"issue":"4","key":"4414_CR33","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.4314\/ahs.v18i4.37","volume":"18","author":"AA Kadry","year":"2018","unstructured":"Kadry AA, El-Ganiny AM, El-Baz AM (2018) Relationship between Sap prevalence and biofilm formation among resistant clinical isolates of Candida albicans. Afr Health Sci 18(4):1166\u20131174. https:\/\/doi.org\/10.4314\/ahs.v18i4.37","journal-title":"Afr Health Sci"},{"issue":"1","key":"4414_CR34","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1038\/s41467-018-06607-1","volume":"9","author":"L Kasper","year":"2018","unstructured":"Kasper L, K\u00f6nig A, Koenig P-A, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Gro\u00df O, Ruland J, Naglik JR, Hube B (2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun 9(1):4260. https:\/\/doi.org\/10.1038\/s41467-018-06607-1","journal-title":"Nat Commun"},{"issue":"3","key":"4414_CR35","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1177\/154405910708600304","volume":"86","author":"L Li","year":"2007","unstructured":"Li L, Redding S, Dongari-Bagtzoglou A (2007) Candida glabrata: an emerging oral opportunistic pathogen. J Dent Res 86(3):204\u2013215. https:\/\/doi.org\/10.1177\/154405910708600304","journal-title":"J Dent Res"},{"issue":"7902","key":"4414_CR36","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41586-022-04502-w","volume":"603","author":"XV Li","year":"2022","unstructured":"Li XV, Leonardi I, Putzel GG, Semon A, Fiers WD, Kusakabe T, Lin W-Y, Gao IH, Doron I, Gutierrez-Guerrero A, DeCelie MB, Carriche GM, Mesko M, Yang C, Naglik JR, Hube B, Scherl EJ, Iliev ID (2022) Immune regulation by fungal strain diversity in inflammatory bowel disease. Nature 603(7902):672\u2013678. https:\/\/doi.org\/10.1038\/s41586-022-04502-w","journal-title":"Nature"},{"issue":"8004","key":"4414_CR37","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/s41586-024-07142-4","volume":"627","author":"S-H Liang","year":"2024","unstructured":"Liang S-H, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough LD, Chen Y-H, Frazer C, Schille TB, Allert S, Elshafee O, H\u00e4nel M, Mogavero S, Vaishnava S, Cadwell K, Belenky P, Perez JC, Hube B, Ene IV, Bennett RJ (2024) The hyphal-specific toxin Candidalysin promotes fungal gut commensalism. Nature 627(8004):620\u2013627. https:\/\/doi.org\/10.1038\/s41586-024-07142-4","journal-title":"Nature"},{"issue":"6","key":"4414_CR38","doi-asserted-by":"publisher","first-page":"e1013284","DOI":"10.1371\/journal.ppat.1013284","volume":"21","author":"J Lin","year":"2025","unstructured":"Lin J, Filler SG (2025) Host targets of Candidalysin. PLoS Pathog 21(6):e1013284. https:\/\/doi.org\/10.1371\/journal.ppat.1013284","journal-title":"PLoS Pathog"},{"key":"4414_CR39","doi-asserted-by":"publisher","unstructured":"Lortal L, Lyon CM, Sprague JL, Sonnberger J, Paulin OKA, Wickramasinghe DN, Richardson JP, Hube B, Naglik JR (2025) Candidalysin biology and activation of host cells. mBio 16(6). https:\/\/doi.org\/10.1128\/mbio.00603-24","DOI":"10.1128\/mbio.00603-24"},{"issue":"2","key":"4414_CR40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ram.2022.08.003","volume":"55","author":"IU Macias-Paz","year":"2023","unstructured":"Macias-Paz IU, P\u00e9rez-Hern\u00e1ndez S, Tavera-Tapia A, Luna-Arias JP, Guerra-C\u00e1rdenas JE, Reyna-Beltr\u00e1n E (2023) Candida albicans the main opportunistic pathogenic fungus in humans. Rev Argent Microbiol 55(2):189\u2013198. https:\/\/doi.org\/10.1016\/j.ram.2022.08.003","journal-title":"Rev Argent Microbiol"},{"issue":"3","key":"4414_CR41","doi-asserted-by":"publisher","first-page":"e58613","DOI":"10.1371\/journal.pone.0058613","volume":"8","author":"R Martin","year":"2013","unstructured":"Martin R, Albrecht-Eckardt D, Brunke S, Hube B, H\u00fcnniger K, Kurzai O (2013) A core filamentation response network in Candida albicans is restricted to eight genes. PLoS ONE 8(3):e58613. https:\/\/doi.org\/10.1371\/journal.pone.0058613","journal-title":"PLoS ONE"},{"issue":"2","key":"4414_CR42","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4161\/viru.22913","volume":"4","author":"FL Mayer","year":"2013","unstructured":"Mayer FL, Wilson D, Hube B (2013) Candida albicans pathogenicity mechanisms. Virulence 4(2):119\u2013128. https:\/\/doi.org\/10.4161\/viru.22913","journal-title":"Virulence"},{"issue":"2","key":"4414_CR43","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.idc.2021.03.007","volume":"35","author":"TP McCarty","year":"2021","unstructured":"McCarty TP, White CM, Pappas PG (2021) Candidemia and invasive candidiasis. Infect Dis Clin N Am 35(2):389\u2013413. https:\/\/doi.org\/10.1016\/j.idc.2021.03.007","journal-title":"Infect Dis Clin N Am"},{"key":"4414_CR44","doi-asserted-by":"publisher","unstructured":"Morelli M, Queiroz K (2024) Mycotoxin Candidalysin impairs epithelial barrier integrity and initiates inflammation in a gut-on-chip model. BioRxiv 20241030621017. https:\/\/doi.org\/10.1101\/2024.10.30.621017","DOI":"10.1101\/2024.10.30.621017"},{"issue":"4","key":"4414_CR45","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1080\/21505594.2015.1012981","volume":"6","author":"DL Moyes","year":"2015","unstructured":"Moyes DL, Richardson JP, Naglik JR (2015) Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface. Virulence 6(4):338\u2013346. https:\/\/doi.org\/10.1080\/21505594.2015.1012981","journal-title":"Virulence"},{"issue":"7597","key":"4414_CR46","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature17625","volume":"532","author":"DL Moyes","year":"2016","unstructured":"Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, H\u00f6fs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, F\u00f6rster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Naglik JR (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597):64\u201368. https:\/\/doi.org\/10.1038\/nature17625","journal-title":"Nature"},{"issue":"3","key":"4414_CR47","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41564-024-01606-z","volume":"9","author":"R M\u00fcller","year":"2024","unstructured":"M\u00fcller R, K\u00f6nig A, Groth S, Zarnowski R, Visser C, Handrianz T, Maufrais C, Kr\u00fcger T, Himmel M, Lee S, Priest EL, Yildirim D, Richardson JP, Blango MG, Bougnoux M-E, Kniemeyer O, d\u2019Enfert C, Brakhage AA, Andes DR, Hube B (2024) Secretion of the fungal toxin Candidalysin is dependent on conserved precursor peptide sequences. Nat Microbiol 9(3):669\u2013683. https:\/\/doi.org\/10.1038\/s41564-024-01606-z","journal-title":"Nat Microbiol"},{"key":"4414_CR48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.mib.2019.06.002","volume":"52","author":"JR Naglik","year":"2019","unstructured":"Naglik JR, Gaffen SL, Hube B (2019) Candidalysin: discovery and function in Candida albicans infections. Curr Opin Microbiol 52:100\u2013109. https:\/\/doi.org\/10.1016\/j.mib.2019.06.002","journal-title":"Curr Opin Microbiol"},{"issue":"46","key":"4414_CR49","doi-asserted-by":"publisher","first-page":"28954","DOI":"10.1074\/jbc.272.46.28954","volume":"272","author":"G Newport","year":"1997","unstructured":"Newport G, Agabian N (1997) KEX2 influences Candida albicans proteinase secretion and hyphal formation. J Biol Chem 272(46):28954\u201328961. https:\/\/doi.org\/10.1074\/jbc.272.46.28954","journal-title":"J Biol Chem"},{"issue":"3","key":"4414_CR50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.fgb.2010.08.010","volume":"48","author":"S Nicholls","year":"2011","unstructured":"Nicholls S, MacCallum DM, Kaffarnik FAR, Selway L, Peck SC, Brown AJP (2011) Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans. Fungal Genet Biology: FG B 48(3):297\u2013305. https:\/\/doi.org\/10.1016\/j.fgb.2010.08.010","journal-title":"Fungal Genet Biology: FG B"},{"issue":"2","key":"4414_CR51","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1399-302x.1995.tb00128.x","volume":"10","author":"H Nikawa","year":"1995","unstructured":"Nikawa H, Nishimura H, Yamamoto T, Samaranayake LP (1995) A novel method to study the hyphal phase of Candida albicans and to evaluate its hydrophobicity. Oral Microbiol Immunol 10(2):110\u2013114. https:\/\/doi.org\/10.1111\/j.1399-302x.1995.tb00128.x","journal-title":"Oral Microbiol Immunol"},{"issue":"1\u20132","key":"4414_CR52","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cell.2011.10.048","volume":"148","author":"CJ Nobile","year":"2012","unstructured":"Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148(1\u20132):126\u2013138. https:\/\/doi.org\/10.1016\/j.cell.2011.10.048","journal-title":"Cell"},{"issue":"2","key":"4414_CR53","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nrmicro.2016.157","volume":"15","author":"SM Noble","year":"2017","unstructured":"Noble SM, Gianetti BA, Witchley JN (2017) Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol 15(2):96\u2013108. https:\/\/doi.org\/10.1038\/nrmicro.2016.157","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"4414_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1040841X.2021.1935447","volume":"48","author":"SA Padder","year":"2022","unstructured":"Padder SA, Ramzan A, Tahir I, Rehman RU, Shah AH (2022) Metabolic flexibility and extensive adaptability governing multiple drug resistance and enhanced virulence in Candida albicans. Crit Rev Microbiol 48(1):1\u201320. https:\/\/doi.org\/10.1080\/1040841X.2021.1935447","journal-title":"Crit Rev Microbiol"},{"issue":"8","key":"4414_CR55","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1139\/w08-048","volume":"54","author":"MG Paraje","year":"2008","unstructured":"Paraje MG, Correa SG, Renna MS, Theumer M, Sotomayor CE (2008) Candida albicans-secreted lipase induces injury and steatosis in immune and parenchymal cells. Can J Microbiol 54(8):647\u2013659. https:\/\/doi.org\/10.1139\/w08-048","journal-title":"Can J Microbiol"},{"issue":"2","key":"4414_CR56","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5941\/MYCO.2013.41.2.67","volume":"41","author":"M Park","year":"2013","unstructured":"Park M, Do E, Jung WH (2013) Lipolytic enzymes involved in the virulence of human pathogenic fungi. Mycobiology 41(2):67\u201372. https:\/\/doi.org\/10.5941\/MYCO.2013.41.2.67","journal-title":"Mycobiology"},{"issue":"3","key":"4414_CR57","doi-asserted-by":"publisher","first-page":"151490","DOI":"10.1016\/j.ijmm.2021.151490","volume":"311","author":"JC P\u00e9rez","year":"2021","unstructured":"P\u00e9rez JC (2021) Fungi of the human gut microbiota: roles and significance. Int J Med Microbiol 311(3):151490. https:\/\/doi.org\/10.1016\/j.ijmm.2021.151490","journal-title":"Int J Med Microbiol"},{"key":"4414_CR58","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.23.529756","author":"QT Phan","year":"2023","unstructured":"Phan QT, Solis NV, Cravener MV, Swidergall M, Lin J, Huang MY, Liu H, Singh S, Ibrahim AS, Mazzone M, Mitchell AP, Filler SG (2023) Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. Microbiology. https:\/\/doi.org\/10.1101\/2023.02.23.529756","journal-title":"Microbiology"},{"issue":"12","key":"4414_CR59","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1074\/jbc.M117.810440","volume":"293","author":"E Reyna-Beltr\u00e1n","year":"2018","unstructured":"Reyna-Beltr\u00e1n E, Iranzo M, Calder\u00f3n-Gonz\u00e1lez KG, Mondrag\u00f3n-Flores R, Labra-Barrios ML, Mormeneo S, Luna-Arias JP (2018) The Candida albicans ENO1 gene encodes a transglutaminase involved in growth, cell division, morphogenesis, and osmotic protection. J Biol Chem 293(12):4304\u20134323. https:\/\/doi.org\/10.1074\/jbc.M117.810440","journal-title":"J Biol Chem"},{"issue":"1","key":"4414_CR61","doi-asserted-by":"publisher","first-page":"e02178","DOI":"10.1128\/mBio.02178-17","volume":"9","author":"JP Richardson","year":"2018","unstructured":"Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Kr\u00fcger T, Verma AH, Coleman BM, Diaz DLC, Schulz J, Ponde D, Carrano NO, Kniemeyer G, Wilson O, Bader D, Enoiu O, Ho SI, Kichik J, Gaffen N, Hube SL, B., Naglik JR (2018) Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence. mBio 9(1):e02178\u2013e02117. https:\/\/doi.org\/10.1128\/mBio.02178-17","journal-title":"mBio"},{"issue":"1","key":"4414_CR60","doi-asserted-by":"publisher","first-page":"e03510","DOI":"10.1128\/mbio.03510-21","volume":"13","author":"JP Richardson","year":"2022","unstructured":"Richardson JP, Brown R, Kichik N, Lee S, Priest E, Mogavero S, Maufrais C, Wickramasinghe DN, Tsavou A, Kotowicz NK, Hepworth OW, Gallego-Cort\u00e9s A, Ponde NO, Ho J, Moyes DL, Wilson D, D\u2019Enfert C, Hube B, Naglik JR (2022) Candidalysins are a new family of cytolytic fungal peptide toxins. mBio 13(1):e03510\u2013e03521. https:\/\/doi.org\/10.1128\/mbio.03510-21","journal-title":"mBio"},{"issue":"1","key":"4414_CR62","doi-asserted-by":"publisher","first-page":"e02221","DOI":"10.1128\/mBio.02221-18","volume":"10","author":"O Rogiers","year":"2019","unstructured":"Rogiers O, Frising UC, Kuchar\u00edkov\u00e1 S, Jabra-Rizk MA, van Loo G, Van Dijck P, Wullaert A (2019) Candidalysin crucially contributes to Nlrp3 inflammasome activation by Candida albicans hyphae. mBio 10(1):e02221\u2013e02218. https:\/\/doi.org\/10.1128\/mBio.02221-18","journal-title":"mBio"},{"issue":"6","key":"4414_CR63","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1590\/S1806-83242013000600007","volume":"27","author":"RD Rossoni","year":"2013","unstructured":"Rossoni RD, Barbosa JO, Vilela SFG, Jorge AOC, Junqueira JC (2013) Comparison of the hemolytic activity between C. albicans and non-albicans Candida species. Brazilian Oral Res 27(6):484\u2013489. https:\/\/doi.org\/10.1590\/S1806-83242013000600007","journal-title":"Brazilian Oral Res"},{"key":"4414_CR64","doi-asserted-by":"publisher","unstructured":"Ruben S, Garbe E, Mogavero S, Albrecht-Eckardt D, Hellwig D, H\u00e4der A, Kr\u00fcger T, Gerth K, Jacobsen ID, Elshafee O, Brunke S, H\u00fcnniger K, Kniemeyer O, Brakhage AA, Morschh\u00e4user J, Hube B, Vylkova S, Kurzai O, Martin R (2020) Ahr1 and Tup1 contribute to the transcriptional control of Virulence-Associated genes in Candida albicans. mBio 11(2). https:\/\/doi.org\/10.1128\/mbio.00206-20","DOI":"10.1128\/mbio.00206-20"},{"issue":"4","key":"4414_CR65","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2174\/138945006776359421","volume":"7","author":"M Ruhnke","year":"2006","unstructured":"Ruhnke M (2006) Epidemiology of Candida albicans infections and role of non-Candida-albicans yeasts. Curr Drug Targets 7(4):495\u2013504. https:\/\/doi.org\/10.2174\/138945006776359421","journal-title":"Curr Drug Targets"},{"key":"4414_CR66","doi-asserted-by":"publisher","first-page":"e75490","DOI":"10.7554\/eLife.75490","volume":"11","author":"CM Russell","year":"2022","unstructured":"Russell CM, Schaefer KG, Dixson A, Gray ALH, Pyron RJ, Alves DS, Moore N, Conley EA, Schuck RJ, White TA, Do TD, King GM, Barrera FN (2022) The Candida albicans virulence factor Candidalysin polymerizes in solution to form membrane pores and damage epithelial cells. eLife 11:e75490. https:\/\/doi.org\/10.7554\/eLife.75490","journal-title":"eLife"},{"issue":"Pt 1","key":"4414_CR67","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1099\/jmm.0.045054-0","volume":"62","author":"JCO Sardi","year":"2013","unstructured":"Sardi JCO, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJS (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol 62(Pt 1):10\u201324. https:\/\/doi.org\/10.1099\/jmm.0.045054-0","journal-title":"J Med Microbiol"},{"issue":"4","key":"4414_CR68","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/bip.10260","volume":"66","author":"Y Shai","year":"2002","unstructured":"Shai Y (2002) Mode of action of membrane active antimicrobial peptides. Biopolymers 66(4):236\u2013248. https:\/\/doi.org\/10.1002\/bip.10260","journal-title":"Biopolymers"},{"issue":"10","key":"4414_CR69","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.3201\/eid2410.180801","volume":"24","author":"SA Shankarnarayan","year":"2018","unstructured":"Shankarnarayan SA, Rudramurthy SM, Chakrabarti A, Shaw D, Paul S, Sethuraman N, Kaur H, Ghosh AK (2018) Molecular typing and antifungal susceptibility of Candida viswanathii, India. Emerg Infect Dis 24(10):1956\u20131958. https:\/\/doi.org\/10.3201\/eid2410.180801","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"4414_CR70","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nrmicro2636","volume":"9","author":"PE Sudbery","year":"2011","unstructured":"Sudbery PE (2011) Growth of Candida albicans hyphae. Nat Rev Microbiol 9(10):737\u2013748. https:\/\/doi.org\/10.1038\/nrmicro2636","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"4414_CR71","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.tim.2004.05.008","volume":"12","author":"P Sudbery","year":"2004","unstructured":"Sudbery P, Gow N, Berman J (2004) The distinct morphogenic States of Candida albicans. Trends Microbiol 12(7):317\u2013324. https:\/\/doi.org\/10.1016\/j.tim.2004.05.008","journal-title":"Trends Microbiol"},{"issue":"9","key":"4414_CR72","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1093\/infdis\/jiz322","volume":"220","author":"M Swidergall","year":"2019","unstructured":"Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG, Naglik JR (2019) Candidalysin is required for neutrophil recruitment and virulence during systemic Candida albicans infection. J Infect Dis 220(9):1477\u20131488. https:\/\/doi.org\/10.1093\/infdis\/jiz322","journal-title":"J Infect Dis"},{"issue":"1","key":"4414_CR73","doi-asserted-by":"publisher","first-page":"e1009221","DOI":"10.1371\/journal.ppat.1009221","volume":"17","author":"M Swidergall","year":"2021","unstructured":"Swidergall M, Solis NV, Millet N, Huang MY, Lin J, Phan QT, Lazarus MD, Wang Z, Yeaman MR, Mitchell AP, Filler SG (2021) Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors. PLoS Pathog 17(1):e1009221. https:\/\/doi.org\/10.1371\/journal.ppat.1009221","journal-title":"PLoS Pathog"},{"issue":"2","key":"4414_CR74","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3390\/jof7020079","volume":"7","author":"J Talapko","year":"2021","unstructured":"Talapko J, Juzba\u0161i\u0107 M, Matijevi\u0107 T, Pustijanac E, Beki\u0107 S, Kotris I, \u0160krlec I (2021) Candida albicans\u2014The virulence factors and clinical manifestations of infection. J Fungi 7(2):79. https:\/\/doi.org\/10.3390\/jof7020079","journal-title":"J Fungi"},{"issue":"7","key":"4414_CR75","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41587-021-01156-3","volume":"40","author":"F Teufel","year":"2022","unstructured":"Teufel F, Armenteros A, Johansen JJ, G\u00edslason AR, Pihl MH, Tsirigos SI, Winther KD, Brunak O, Von Heijne S, G., Nielsen H (2022) SignalP 6.0 predicts all five types of signal peptides using protein Language models. Nat Biotechnol 40(7):1023\u20131025. https:\/\/doi.org\/10.1038\/s41587-021-01156-3","journal-title":"Nat Biotechnol"},{"issue":"6414","key":"4414_CR76","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1126\/science.aat0537","volume":"362","author":"GHW Tso","year":"2018","unstructured":"Tso GHW, Reales-Calderon JA, Tan ASM, Sem X, Le GTT, Tan TG, Lai GC, Srinivasan KG, Yurieva M, Liao W, Poidinger M, Zolezzi F, Rancati G, Pavelka N (2018) Experimental evolution of a fungal pathogen into a gut symbiont. Science 362(6414):589\u2013595. https:\/\/doi.org\/10.1126\/science.aat0537","journal-title":"Science"},{"issue":"2","key":"4414_CR77","doi-asserted-by":"publisher","first-page":"627","DOI":"10.4049\/jimmunol.1800515","volume":"201","author":"AH Verma","year":"2018","unstructured":"Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL (2018) IL-36 and IL-1\/IL-17 drive immunity to oral candidiasis via parallel mechanisms. J Immunol (Baltimore Md: 1950) 201(2):627\u2013634. https:\/\/doi.org\/10.4049\/jimmunol.1800515","journal-title":"J Immunol (Baltimore Md: 1950)"},{"key":"4414_CR78","doi-asserted-by":"crossref","unstructured":"Vilela MMS, Kamei K, Sano A, Tanaka R, Uno J, Takahashi I, Ito J, Yarita K, Miyaji M (2002) Pathogenicity and virulence of Candida dubliniensis: Comparison with C. albicans. Medical Mycology","DOI":"10.1080\/714031113"},{"issue":"4","key":"4414_CR79","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1399-302X.2004.00150.x","volume":"19","author":"CC Villar","year":"2004","unstructured":"Villar CC, Kashleva H, Dongari-Bagtzoglou A (2004) Role of Candida albicans polymorphism in interactions with oral epithelial cells. Oral Microbiol Immunol 19(4):262\u2013269. https:\/\/doi.org\/10.1111\/j.1399-302X.2004.00150.x","journal-title":"Oral Microbiol Immunol"},{"issue":"8","key":"4414_CR80","doi-asserted-by":"publisher","first-page":"e03351","DOI":"10.1128\/mbio.03351-23","volume":"15","author":"DN Wickramasinghe","year":"2024","unstructured":"Wickramasinghe DN, Lyon CM, Lee S, Hepworth OW, Priest EL, Maufrais C, Ryan AP, Permal E, Sullivan D, McManus BA, Hube B, Butler G, d\u2019Enfert C, Naglik JR, Richardson JP (2024) Variations in Candidalysin amino acid sequence influence toxicity and host responses. mBio 15(8):e03351\u2013e03323. https:\/\/doi.org\/10.1128\/mbio.03351-23","journal-title":"mBio"},{"issue":"12","key":"4414_CR81","doi-asserted-by":"publisher","first-page":"e00527","DOI":"10.1128\/IAI.00527-18","volume":"86","author":"HME Willems","year":"2018","unstructured":"Willems HME, Lowes DJ, Barker KS, Palmer GE, Peters BM (2018) Comparative analysis of the capacity of the Candida species to elicit vaginal immunopathology. Infect Immun 86(12):e00527\u2013e00518. https:\/\/doi.org\/10.1128\/IAI.00527-18","journal-title":"Infect Immun"},{"issue":"1","key":"4414_CR82","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.chom.2008.05.014","volume":"4","author":"X-L Xu","year":"2008","unstructured":"Xu X-L, Lee RTH, Fang H-M, Wang Y-M, Li R, Zou H, Zhu Y, Wang Y (2008) Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p. Cell Host Microbe 4(1):28\u201339. https:\/\/doi.org\/10.1016\/j.chom.2008.05.014","journal-title":"Cell Host Microbe"},{"key":"4414_CR83","doi-asserted-by":"publisher","unstructured":"Yuan L, Lu H, Li F, Nielsen J, Kerkhoven EJ (2023) HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer. Brief Bioinform 24(2). https:\/\/doi.org\/10.1093\/bib\/bbad035","DOI":"10.1093\/bib\/bbad035"},{"key":"4414_CR84","doi-asserted-by":"publisher","unstructured":"Zhou X (2024) Exploring the role of Candidalysin in the pathogenicity of Candida albicans by gene set enrichment analysis and evolutionary dynamics. Am J Translational Res 16(7) Article 7. https:\/\/doi.org\/10.62347\/IZYM9087","DOI":"10.62347\/IZYM9087"},{"key":"4414_CR85","doi-asserted-by":"publisher","unstructured":"Zuza-Alves DL, Silva-Rocha WP, Chaves GM (2017) An Update on Candida tropicalis Based on Basic and Clinical Approaches. Frontiers in Microbiology, 8, 1927. https:\/\/doi.org\/10.3389\/fmicb.2017.01927","DOI":"10.3389\/fmicb.2017.01927"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04414-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-025-04414-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04414-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:55:06Z","timestamp":1756371306000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-025-04414-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4414"],"URL":"https:\/\/doi.org\/10.1007\/s00203-025-04414-z","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"206"}}