{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:57:21Z","timestamp":1782410241196,"version":"3.54.5"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00203-025-04501-1","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T10:21:40Z","timestamp":1760091700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Probable role of naturally derived bergapten molecule promotes autophagy in Mycobacterium tuberculosis-infected macrophages via PI3K\/Akt\/mTOR pathway"],"prefix":"10.1007","volume":"207","author":[{"given":"Jayashri","family":"Seetharaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam Ebenezer","family":"Rajadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh","family":"Sounderrajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshaya Priya","family":"Raveendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reya Rene","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankari","family":"Dharmalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"4501_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1\u20132","author":"MJ Abraham","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R et al (2015) Gromacs: high performance molecular simulations through multilevel parallelism from laptops to supercomputers. SoftwareX 1\u20132:19\u201325. https:\/\/doi.org\/10.1016\/j.softx.2015.06.001","journal-title":"SoftwareX"},{"key":"4501_CR2","doi-asserted-by":"publisher","unstructured":"Adeniji SE, Adalumo OB, Ekoja FO (2020a) Anti-tubercular modeling, molecular Docking simulation and insight toward computational design of novel compounds as potent antagonist against DNA gyrase receptor. Med Microecology 5. https:\/\/doi.org\/10.1016\/j.medmic.2020.100020","DOI":"10.1016\/j.medmic.2020.100020"},{"key":"4501_CR3","doi-asserted-by":"publisher","unstructured":"Adeniji SE, Uba S, Uzairu A (2020b) Multilinear regression model, molecular binding interactions and ligand-based design of some prominent compounds against Mycobacterium tuberculosis. Netw Model Anal Health Inf Bioinf 9. https:\/\/doi.org\/10.1007\/s13721-019-0212-6","DOI":"10.1007\/s13721-019-0212-6"},{"key":"4501_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jksus.2014.12.004","volume":"27","author":"OO Ajileye","year":"2015","unstructured":"Ajileye OO, Obuotor EM, Akinkunmi EO, Aderogba MA (2015) Isolation and characterization of antioxidant and antimicrobial compounds from anacardium occidentale L. (Anacardiaceae) leaf extract. J King Saud Univ Sci 27:244\u2013252. https:\/\/doi.org\/10.1016\/j.jksus.2014.12.004","journal-title":"J King Saud Univ Sci"},{"key":"4501_CR5","doi-asserted-by":"publisher","unstructured":"Alsaadi RM, Losier TT, Tian W et al (2019) ULK1-mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 crohn\u2019s mutant. EMBO Rep 20. https:\/\/doi.org\/10.15252\/embr.201846885","DOI":"10.15252\/embr.201846885"},{"key":"4501_CR6","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.biocel.2005.10.021","volume":"38","author":"PK Anand","year":"2006","unstructured":"Anand PK, Kaul D, Sharma M (2006) Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. Int J Biochem Cell Biology 38:600\u2013609. https:\/\/doi.org\/10.1016\/j.biocel.2005.10.021","journal-title":"Int J Biochem Cell Biology"},{"key":"4501_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.71.e129151","volume":"71","author":"M Askar","year":"2024","unstructured":"Askar M (2024) Computational quest to inhibit enoyl-acyl carrier protein reductase (InhA) enzyme in Mycobacterium tuberculosis from Lannea coromandelica (Houtt.) Merr. Metabolite via molecular Docking and dynamics. Pharmacia 71:1\u201310. https:\/\/doi.org\/10.3897\/pharmacia.71.e129151","journal-title":"Pharmacia"},{"key":"4501_CR8","doi-asserted-by":"publisher","unstructured":"Ayesh BM, Abed AA, Faris DM (2014) In vitro Inhibition of human leukemia THP-1 cells by Origanum syriacum L. and thymus vulgaris L. extracts. BMC Res Notes 7. https:\/\/doi.org\/10.1186\/1756-0500-7-612","DOI":"10.1186\/1756-0500-7-612"},{"key":"4501_CR9","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1111\/resp.12762","volume":"21","author":"X Bai","year":"2016","unstructured":"Bai X, Oberley-Deegan RE, Bai A et al (2016) Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection. Respirology 21:951\u2013957. https:\/\/doi.org\/10.1111\/resp.12762","journal-title":"Respirology"},{"key":"4501_CR10","doi-asserted-by":"publisher","unstructured":"Bartnik M, S\u0142awi\u0144ska-Brych A, Mizerska-Kowalska M, Zdzisi\u0144ska B (2023) Evaluation of the biological effect of Non-UV-Activated Bergapten on selected human tumor cells and the insight into the molecular mechanism of its action. Int J Mol Sci 24. https:\/\/doi.org\/10.3390\/ijms242115555","DOI":"10.3390\/ijms242115555"},{"key":"4501_CR11","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1194\/jlr.RA120000895","volume":"61","author":"N Bruiners","year":"2020","unstructured":"Bruiners N, Dutta NK, Guerrini V et al (2020) The anti-tubercular activity of Simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis. J Lipid Res 61:1617\u20131628. https:\/\/doi.org\/10.1194\/jlr.RA120000895","journal-title":"J Lipid Res"},{"key":"4501_CR12","doi-asserted-by":"publisher","unstructured":"De Amicis F, Aquila S, Morelli C et al (2015a) Bergapten drives autophagy through the upregulation of PTEN expression in breast cancer cells. Mol Cancer 14. https:\/\/doi.org\/10.1186\/S12943-015-0403-4","DOI":"10.1186\/S12943-015-0403-4"},{"key":"4501_CR13","doi-asserted-by":"publisher","unstructured":"De Amicis F, Aquila S, Morelli C et al (2015b) Bergapten drives autophagy through the upregulation of PTEN expression in breast cancer cells. Mol Cancer 14. https:\/\/doi.org\/10.1186\/s12943-015-0403-4","DOI":"10.1186\/s12943-015-0403-4"},{"key":"4501_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-1-0716-3052-5_2","volume-title":"Cell viability assays: methods and protocols","author":"Ghasemi Mahshid","year":"2023","unstructured":"Ghasemi Mahshid, Liang S, LQM and KI (2023) The MTT assay: A method for error minimization and interpretation in measuring cytotoxicity and estimating cell viability. In: Friedrich O, Gilbert DF (eds) Cell viability assays: methods and protocols. Springer US, New York, NY, pp 15\u201333"},{"key":"4501_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/jphp.12162","volume":"66","author":"S Giovagnoli","year":"2014","unstructured":"Giovagnoli S, Marenzoni ML, Nocchetti M et al (2014) Synthesis, characterization and in vitro extracellular and intracellular activity against Mycobacterium tuberculosis infection of new second-line antitubercular drug-palladium complexes. J Pharm Pharmacol 66:106\u2013121. https:\/\/doi.org\/10.1111\/jphp.12162","journal-title":"J Pharm Pharmacol"},{"key":"4501_CR16","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00044-016-1595-x","volume":"25","author":"F Golfakhrabadi","year":"2016","unstructured":"Golfakhrabadi F, Shams Ardakani MR, Saeidnia S et al (2016) In vitro antimicrobial and acetylcholinesterase inhibitory activities of coumarins from ferulago carduchorum. Med Chem Res 25:1623\u20131629. https:\/\/doi.org\/10.1007\/s00044-016-1595-x","journal-title":"Med Chem Res"},{"key":"4501_CR17","doi-asserted-by":"publisher","first-page":"25511","DOI":"10.1039\/d1ra02800f","volume":"11","author":"M Govinda raj","year":"2021","unstructured":"Govinda raj M, Vijayakumar E, Neppolian B et al (2021) Influence of ag nanoparticles anchored on protonated g-C3N4-Bi2MoO6nanocomposites for effective antibiotic and organic pollutant degradation. RSC Adv 11:25511\u201325523. https:\/\/doi.org\/10.1039\/d1ra02800f","journal-title":"RSC Adv"},{"key":"4501_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/MCP.0000000000000866","volume":"28","author":"G G\u00fcnther","year":"2022","unstructured":"G\u00fcnther G, Ruswa N, Keller PM (2022) Drug-resistant tuberculosis: advances in diagnosis and management. Curr Opin Pulm Med 28:211\u2013217","journal-title":"Curr Opin Pulm Med"},{"key":"4501_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-84","author":"P Gupta","year":"2014","unstructured":"Gupta P, Bhatter P, D\u2019souza D et al (2014) Evaluating the anti Mycobacterium tuberculosis activity of Alpinia Galanga (L.) Willd. Axenically under reducing oxygen conditions and in intracellular assays. BMC Complement Altern Med. https:\/\/doi.org\/10.1186\/1472-6882-14-84. 14:","journal-title":"BMC Complement Altern Med"},{"key":"4501_CR20","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1080\/13880209.2017.1309440","volume":"55","author":"VK Gupta","year":"2017","unstructured":"Gupta VK, Kumar MM, Bisht D, Kaushik A (2017) Plants in our combating strategies against Mycobacterium tuberculosis: progress made and Obstacles Met. Pharm Biol 55:1536\u20131544","journal-title":"Pharm Biol"},{"key":"4501_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.intimp.2015.12.027","volume":"31","author":"S Guzm\u00e1n-Beltr\u00e1n","year":"2016","unstructured":"Guzm\u00e1n-Beltr\u00e1n S, Rubio-Badillo M\u00c1, Ju\u00e1rez E et al (2016) Nordihydroguaiaretic acid (NDGA) and \u03b1-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy. Int Immunopharmacol 31:149\u2013157. https:\/\/doi.org\/10.1016\/j.intimp.2015.12.027","journal-title":"Int Immunopharmacol"},{"key":"4501_CR22","doi-asserted-by":"publisher","unstructured":"Horv\u00e1ti K, Fodor K, P\u00e1lyi B et al (2021) Novel assay platform to evaluate intracellular killing of Mycobacterium tuberculosis: in vitro and. Vivo Validation Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.750496","DOI":"10.3389\/fimmu.2021.750496"},{"key":"4501_CR23","doi-asserted-by":"publisher","unstructured":"Islam MI, Seo H, Kim S et al (2021) Antimicrobial activity of IDD-B40 against drug-resistant Mycobacterium tuberculosis. Sci Rep 11. https:\/\/doi.org\/10.1038\/s41598-020-80227-y","DOI":"10.1038\/s41598-020-80227-y"},{"key":"4501_CR24","doi-asserted-by":"publisher","unstructured":"Jagannath C, McBride JW, Vergne I (2021) Editorial: the autophagy pathway: bacterial pathogen immunity and evasion. Front Immunol 12. https:\/\/doi.org\/10.3389\/fimmu.2021.768935","DOI":"10.3389\/fimmu.2021.768935"},{"key":"4501_CR25","doi-asserted-by":"publisher","unstructured":"Jowsey WJ, Cook GM, McNeil MB (2024) Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors. JAC Antimicrob Resist 6. https:\/\/doi.org\/10.1093\/jacamr\/dlae086","DOI":"10.1093\/jacamr\/dlae086"},{"key":"4501_CR26","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1007\/s11164-022-04906-3","volume":"49","author":"P Kamalarajan","year":"2023","unstructured":"Kamalarajan P, Irshad Ahamed J, Priya R, Valan MF (2023) Spectroscopic, computational DFT, in vitro, and molecular Docking investigations of newly isolated 2, 3, 9, and 10-tetrahydroacridin-3-one from the methanolic extract of Nilavembu kudineer Chooranam. Res Chem Intermed 49:2669\u20132690. https:\/\/doi.org\/10.1007\/s11164-022-04906-3","journal-title":"Res Chem Intermed"},{"key":"4501_CR27","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1002\/JLB.3MA0720-682RR","volume":"108","author":"LLY Kan","year":"2020","unstructured":"Kan LLY, Liu D, Chan BCL et al (2020) The flavonoids of sophora flavescens exerts anti-inflammatory activity by promoting autophagy of Bacillus Calmette-Gu\u00e9rin-stimulated macrophages. J Leukoc Biol 108:1615\u20131629. https:\/\/doi.org\/10.1002\/JLB.3MA0720-682RR","journal-title":"J Leukoc Biol"},{"key":"4501_CR28","doi-asserted-by":"publisher","unstructured":"Kumari A, Saini V, Kumar V (2024) Decreased mRNA expression of NR1H3 and ABCA1 in pulmonary tuberculosis patients from population of Punjab, India. Mol Biol Rep 51. https:\/\/doi.org\/10.1007\/s11033-024-09589-0","DOI":"10.1007\/s11033-024-09589-0"},{"key":"4501_CR29","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1002\/ptr.7221","volume":"35","author":"Y Liang","year":"2021","unstructured":"Liang Y, Xie L, Liu K et al (2021) Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity. Phytother Res 35:6131\u20136147","journal-title":"Phytother Res"},{"key":"4501_CR30","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1038\/s41401-023-01094-7","volume":"44","author":"T Luo","year":"2023","unstructured":"Luo T, Jia X, Feng W, di et al (2023) Bergapten inhibits NLRP3 inflammasome activation and pyroptosis by promoting mitophagy. Acta Pharmacol Sin 44:1867\u20131878. https:\/\/doi.org\/10.1038\/s41401-023-01094-7","journal-title":"Acta Pharmacol Sin"},{"key":"4501_CR31","doi-asserted-by":"publisher","unstructured":"Mohammed HS, Ibrahim MH, Abdel-Aziz MM, Ghareeb MA (2024) Anti-Helicobacter pylori, anti-biofilm activity, and molecular Docking study of citropten, bergapten, and its positional isomer isolated from citrus sinensis L. leaves. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e25232. Heliyon 10:","DOI":"10.1016\/j.heliyon.2024.e25232"},{"key":"4501_CR32","doi-asserted-by":"publisher","unstructured":"Pucci M, Mandrone M, Chiocchio I et al (2022) Different seasonal collections of ficus carica L. Leaves diversely modulate lipid metabolism and adipogenesis in 3T3-L1 adipocytes. https:\/\/doi.org\/10.3390\/nu14142833. Nutrients 14:","DOI":"10.3390\/nu14142833"},{"key":"4501_CR33","doi-asserted-by":"publisher","unstructured":"Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M (2023) Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis. Infect Dis Poverty 12(1):57. https:\/\/doi.org\/10.1186\/s40249-023-01107-x","DOI":"10.1186\/s40249-023-01107-x"},{"key":"4501_CR34","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11696-023-03070-1","volume":"78","author":"S Sathish","year":"2024","unstructured":"Sathish S, Devaraju P, Julius A et al (2024) Identification of selective inhibitors for Janus kinase 1: an integrated drug repurposing strategy for breast cancer. Chem Pap 78:245\u2013262. https:\/\/doi.org\/10.1007\/s11696-023-03070-1","journal-title":"Chem Pap"},{"key":"4501_CR35","doi-asserted-by":"publisher","unstructured":"Seetharaman J, Priya RA, Philip RR et al (2025) Evaluation of Tridax procumbens Secondary Metabolites Anti-Tuberculosis Activity by In Vitro and In Silico Methods. Curr Microbiol 82:1\u201313. https:\/\/doi.org\/10.1007\/S00284-024-04033-9\/FIGURES\/5","DOI":"10.1007\/S00284-024-04033-9\/FIGURES\/5"},{"key":"4501_CR36","doi-asserted-by":"publisher","unstructured":"Sengupta S, Nayak B, Meuli M et al (2021) Mycobacterium tuberculosis phosphoribosyltransferase promotes bacterial survival in macrophages by inducing histone hypermethylation in Autophagy-Related genes. Front Cell Infect Microbiol 11. https:\/\/doi.org\/10.3389\/fcimb.2021.676456","DOI":"10.3389\/fcimb.2021.676456"},{"key":"4501_CR37","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1021\/acsbiomaterials.0c00823","volume":"6","author":"A Sharma","year":"2020","unstructured":"Sharma A, Vaghasiya K, Ray E et al (2020) Targeted pulmonary delivery of the green tea polyphenol Epigallocatechin gallate controls the growth of Mycobacterium tuberculosis by enhancing the autophagy and suppressing bacterial burden. ACS Biomater Sci Eng 6:4126\u20134140. https:\/\/doi.org\/10.1021\/acsbiomaterials.0c00823","journal-title":"ACS Biomater Sci Eng"},{"key":"4501_CR38","doi-asserted-by":"publisher","first-page":"63","DOI":"10.22271\/phyto.2023.v12.i4a.14694","volume":"12","author":"VK Tamrakar","year":"2023","unstructured":"Tamrakar VK, Bhat J, Parihar NS et al (2023) In vitro, evaluation of anti-mycobacterial active plant extracts against Mycobacterium tuberculosis using BACTEC mycobacteria growth indicator tube 960 automated system. J Pharmacogn Phytochem 12:63\u201365. https:\/\/doi.org\/10.22271\/phyto.2023.v12.i4a.14694","journal-title":"J Pharmacogn Phytochem"},{"key":"4501_CR39","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021196","author":"DM Tobin","year":"2015","unstructured":"Tobin DM (2015) Host-directed therapies for tuberculosis. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a021196","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4501_CR40","doi-asserted-by":"crossref","unstructured":"Vaou N, Stavropoulou E, Voidarou C et al (2022) Interactions between medical Plant-Derived bioactive compounds: focus on antimicrobial combination effects. Antibiotics 11:1014","DOI":"10.3390\/antibiotics11081014"},{"key":"4501_CR41","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/abbs\/gmab037","volume":"53","author":"J Wei","year":"2021","unstructured":"Wei J, Zhang X, Li Y et al (2021) Novel application of Bergapten and Quercetin with antibacterial, osteogenesis-potentiating, and anti-inflammation tri-effects. Acta Biochim Biophys Sin (Shanghai) 53:683\u2013696. https:\/\/doi.org\/10.1093\/abbs\/gmab037","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"4501_CR42","doi-asserted-by":"publisher","unstructured":"Yu HJ, Kim TY, Kim G et al (2023) Performance evaluation of the BACTEC MGIT 960 system for Rifampin Drug-Susceptibility testing of Mycobacterium tuberculosis using the current WHO critical concentration. J Clin Microbiol 61. https:\/\/doi.org\/10.1128\/jcm.01086-22","DOI":"10.1128\/jcm.01086-22"},{"key":"4501_CR44","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ijid.2017.04.004","volume":"59","author":"XX Zhang","year":"2017","unstructured":"Zhang XX, Huang TY, Wu Y et al (2017) Inhibition of the PI3K-Akt-mTOR signaling pathway in T lymphocytes in patients with active tuberculosis. Int J Infect Dis 59:110\u2013117. https:\/\/doi.org\/10.1016\/j.ijid.2017.04.004","journal-title":"Int J Infect Dis"},{"key":"4501_CR43","doi-asserted-by":"publisher","unstructured":"Zhang X, Shen T, Zhou X et al (2020) Network Pharmacology based virtual screening of active constituents of prunella vulgaris L. and the molecular mechanism against breast cancer. Sci Rep 10. https:\/\/doi.org\/10.1038\/s41598-020-72797-8","DOI":"10.1038\/s41598-020-72797-8"},{"key":"4501_CR45","doi-asserted-by":"publisher","unstructured":"Zhu Y, Bu S (2017) Curcumin Induces Autophagy, Apoptosis, and Cell Cycle Arrest in Human Pancreatic Cancer Cells. Evidence-based Complementary and Alternative Medicine 2017:. https:\/\/doi.org\/10.1155\/2017\/5787218","DOI":"10.1155\/2017\/5787218"},{"key":"4501_CR46","unstructured":"(2023) Global tuberculosis report 2023. https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/tb-reports\/global-tuberculosis-report-2023"},{"key":"4501_CR47","unstructured":"2024 Global tuberculosis report. https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/tb-reports\/global-tuberculosis-report-2024"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04501-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-025-04501-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-025-04501-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:27:39Z","timestamp":1761380859000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-025-04501-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,10]]},"references-count":47,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["4501"],"URL":"https:\/\/doi.org\/10.1007\/s00203-025-04501-1","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,10]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"are not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}],"article-number":"293"}}