{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:15:51Z","timestamp":1786979751112,"version":"build-2736575974"},"reference-count":234,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Guizhou Provincial Department of Science and Technology","award":["Grant No. Qiankehe Zhicheng [2025] General 321"],"award-info":[{"award-number":["Grant No. Qiankehe Zhicheng [2025] General 321"]}]},{"name":"Guizhou Provincial Department of Science and Technology","award":["Grant No. Qiankehe Zhicheng [2025] General 321"],"award-info":[{"award-number":["Grant No. Qiankehe Zhicheng [2025] General 321"]}]},{"name":"Guizhou Provincial Department of Science and Technology","award":["Grant No. Qiankehe Zhicheng [2025] General 321"],"award-info":[{"award-number":["Grant No. Qiankehe Zhicheng [2025] General 321"]}]},{"name":"Guizhou Provincial Department of Science and Technology","award":["Grant No. Qiankehe Zhicheng [2025] General 321"],"award-info":[{"award-number":["Grant No. Qiankehe Zhicheng [2025] General 321"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00203-026-04928-0","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:46:57Z","timestamp":1779695217000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["T-cell-mediated immunity to influenza A (H2N3): implications for caccine efficacy and cross-subtype protection"],"prefix":"10.1007","volume":"208","author":[{"given":"Jialu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"issue":"4","key":"4928_CR1","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1002\/vms3.819","volume":"8","author":"A Abtin","year":"2022","unstructured":"Abtin A, Shoushtari A, Fallah Mehrabadi MH, Molouki A, Pourbakhsh SA, Pourtaghi H et al (2022) Characterisation, whole-genome sequencing and phylogenetic analysis of three H3N2 avian influenza viruses isolated from domestic ducks at live poultry markets of Iran, 2017: First report. Vet Med Sci 8(4):1594\u20131602","journal-title":"Vet Med Sci"},{"key":"4928_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02309-1","author":"A Akhtar","year":"2025","unstructured":"Akhtar A, Styles TM, Gu C, Le\u00f3n AN, Tharp GK, Stokdyk K et al (2025) Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates. Nat Immunol. https:\/\/doi.org\/10.1038\/s41590-025-02309-1","journal-title":"Nat Immunol"},{"issue":"3","key":"4928_CR3","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.vaccine.2009.10.103","volume":"28","author":"J Alexander","year":"2010","unstructured":"Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S et al (2010) Universal influenza DNA vaccine encoding conserved CD4\u2009+\u2009T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice. Vaccine 28(3):664\u2013672","journal-title":"Vaccine"},{"key":"4928_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.707339","volume":"12","author":"JD Allen","year":"2021","unstructured":"Allen JD, Ross TM (2021) Evaluation of next-generation H3 influenza vaccines in ferrets pre-immune to historical H3N2 viruses. Front Immunol 12:707339","journal-title":"Front Immunol"},{"issue":"4","key":"4928_CR5","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.vaccine.2014.11.054","volume":"33","author":"AF Altenburg","year":"2015","unstructured":"Altenburg AF, Rimmelzwaan GF, de Vries RD (2015) Virus-specific T cells as correlate of (cross-) protective immunity against influenza. Vaccine 33(4):500\u20136","journal-title":"Vaccine"},{"issue":"5284","key":"4928_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.274.5284.94","volume":"274","author":"JD Altman","year":"1996","unstructured":"Altman JD, Moss PAH, Goulder PJR, Barouch DH, McHeyzer-Williams MG, Bell JI et al (1996) Phenotypic Analysis of Antigen-Specific T Lymphocytes. Science 274(5284):94\u20136. https:\/\/doi.org\/10.1126\/science.274.5284.94","journal-title":"Science"},{"issue":"8","key":"4928_CR7","doi-asserted-by":"publisher","first-page":"e00711","DOI":"10.1128\/jvi.00711-24","volume":"98","author":"S Amoah","year":"2024","unstructured":"Amoah S, Cao W, Sayedahmed EE, Wang Y, Kumar A, Mishina M et al (2024) The frequency and function of nucleoprotein-specific CD8\u2009+\u2009T cells are critical for heterosubtypic immunity against influenza virus infection. J Virol 98(8):e00711\u2013e00724","journal-title":"J Virol"},{"issue":"3","key":"4928_CR9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/mt.2013.284","volume":"22","author":"RD Antrobus","year":"2014","unstructured":"Antrobus RD, Coughlan L, Berthoud TK, Dicks MD, Hill AVS, Lambe T et al (2014) Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens. Mol Ther 22(3):668\u2013674","journal-title":"Mol Ther"},{"issue":"5","key":"4928_CR10","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","volume":"162","author":"N Arpaia","year":"2015","unstructured":"Arpaia N, Green JA, Moltedo B, Arvey A, Hemmers S, Yuan S et al (2015) A distinct function of regulatory T cells in tissue protection. Cell 162(5):1078\u20131089","journal-title":"Cell"},{"key":"4928_CR11","doi-asserted-by":"publisher","first-page":"127393","DOI":"10.1016\/j.vaccine.2025.127393","volume":"62","author":"M Ashraf","year":"2025","unstructured":"Ashraf M, Stein AN, Youhanna J, Rockman S, McMahon M, McGovern I et al (2025) The impact of egg adaptation and immune imprinting on influenza vaccine effectiveness. Vaccine 62:127393","journal-title":"Vaccine"},{"issue":"9","key":"4928_CR12","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.humimm.2009.06.004","volume":"70","author":"JAB Babon","year":"2009","unstructured":"Babon JAB, Cruz J, Orphin L, Pazoles P, Co MDT, Ennis FA et al (2009) Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4\u2009+\u2009T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum Immunol 70(9):711\u201321. https:\/\/doi.org\/10.1016\/j.humimm.2009.06.004","journal-title":"Hum Immunol"},{"issue":"9","key":"4928_CR13","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.humimm.2009.06.004","volume":"70","author":"JAB Babon","year":"2009","unstructured":"Babon JAB, Cruz J, Orphin L, Pazoles P, Co MDT, Ennis FA et al (2009) Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4\u2009+\u2009T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum Immunol 70(9):711\u2013721","journal-title":"Hum Immunol"},{"issue":"7","key":"4928_CR14","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1093\/infdis\/jiy291","volume":"218","author":"TM Babu","year":"2018","unstructured":"Babu TM, Perera RAPM, Wu JT, Fitzgerald T, Nolan C, Cowling BJ et al (2018) Population serologic immunity to human and avian H2N2 viruses in the United States and Hong Kong for pandemic risk assessment. J Infect Dis 218(7):1054\u20131060","journal-title":"J Infect Dis"},{"key":"4928_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.virol.2015.02.041","volume":"481","author":"JA Belser","year":"2015","unstructured":"Belser JA, Gustin KM, Katz JM, Maines TR, Tumpey TM (2015) Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses. Virology 481:107\u2013112. https:\/\/doi.org\/10.1016\/j.virol.2015.02.041","journal-title":"Virology"},{"issue":"1","key":"4928_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-00912-1","volume":"9","author":"C Bissett","year":"2024","unstructured":"Bissett C, Belij-Rammerstorfer S, Ulaszewska M, Smith H, Kailath R, Morris S et al (2024) Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine. NPJ Vaccines 9(1):118","journal-title":"NPJ Vaccines"},{"issue":"8","key":"4928_CR18","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.3390\/v20801530","volume":"2","author":"NM Bouvier","year":"2010","unstructured":"Bouvier NM, Lowen AC (2010) Animal models for influenza virus pathogenesis and transmission. Viruses 2(8):1530\u20131565","journal-title":"Viruses"},{"issue":"13","key":"4928_CR17","doi-asserted-by":"publisher","first-page":"7268","DOI":"10.1128\/JVI.07242-12","volume":"86","author":"NM Bouvier","year":"2012","unstructured":"Bouvier NM, Rahmat S, Pica N (2012) Enhanced mammalian transmissibility of seasonal influenza A\/H1N1 viruses encoding an oseltamivir-resistant neuraminidase. J Virol 86(13):7268\u20137279","journal-title":"J Virol"},{"issue":"7","key":"4928_CR19","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/eji.1830230702","volume":"23","author":"P Bowness","year":"1993","unstructured":"Bowness P, Moss PAH, Rowland-Jones S, Bell JI, McMichael AJ (1993) Conservation of T cell receptor usage by HLA B27\u2010restricted influenza\u2010specific cytotoxic T lymphocytes suggests a general pattern for antigen\u2010specific major histocompatibility complex class I\u2010restricted responses. Eur J Immunol 23(7):1417\u20131421","journal-title":"Eur J Immunol"},{"key":"4928_CR20","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02088-25","author":"PH Brigleb","year":"2026","unstructured":"Brigleb PH, Sharp B, Lazure L, Livingston B, Patrick S, Meliopoulos V et al (2026) Immune history confers antibody-and T cell-dependent cross-protection against highly pathogenic avian influenza H5N1 viruses. J Virol. https:\/\/doi.org\/10.1128\/jvi.02088-25","journal-title":"J Virol"},{"issue":"9","key":"4928_CR22","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.4049\/jimmunol.1002241","volume":"187","author":"EL Brincks","year":"2011","unstructured":"Brincks EL, Gurung P, Langlois RA, Hemann EA, Legge KL, Griffith TS (2011) The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL. J Immunol 187(9):4581\u20134588","journal-title":"J Immunol"},{"issue":"7","key":"4928_CR21","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.4049\/jimmunol.181.7.4918","volume":"181","author":"EL Brincks","year":"2008","unstructured":"Brincks EL, Katewa A, Kucaba TA, Griffith TS, Legge KL (2008) CD8 T cells utilize TRAIL to control influenza virus infection. J Immunol 181(7):4918\u20134925","journal-title":"J Immunol"},{"issue":"6","key":"4928_CR23","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1111\/irv.12142","volume":"7","author":"N Budimir","year":"2013","unstructured":"Budimir N, de Haan A, Meijerhof T, Gostick E, Price DA, Huckriede A et al (2013) Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration. Influenza Other Respir Viruses 7(6):1202\u20131209","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"4928_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41541-022-00492-y","volume":"7","author":"BL Bullard","year":"2022","unstructured":"Bullard BL, DeBeauchamp J, Pekarek MJ, Petro-Turnquist E, Vogel P, Webby RJ et al (2022) An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets. NPJ Vaccines 7(1):65","journal-title":"NPJ Vaccines"},{"key":"4928_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1584738","volume":"16","author":"A Buoninfante","year":"2025","unstructured":"Buoninfante A, Cavaleri M (2025) T cells responses after vaccination: a regulatory perspective. Front Immunol 16:1584738","journal-title":"Front Immunol"},{"issue":"8","key":"4928_CR26","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3390\/vaccines9080851","volume":"9","author":"C Butler","year":"2021","unstructured":"Butler C, Ellis C, Folegatti PM, Swayze H, Allen J, Bussey L et al (2021) Efficacy and safety of a modified vaccinia Ankara-NP+ M1 vaccine combined with QIV in people aged 65 and older: a randomised controlled clinical trial (INVICTUS). Vaccines (Basel) 9(8):851","journal-title":"Vaccines (Basel)"},{"issue":"1","key":"4928_CR27","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1038\/s41467-020-15543-y","volume":"11","author":"E Cano-Gamez","year":"2020","unstructured":"Cano-Gamez E, Soskic B, Roumeliotis TI, So E, Smyth DJ, Baldrighi M et al (2020) Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4\u2009+\u2009T cells to cytokines. Nat Commun 11(1):1801","journal-title":"Nat Commun"},{"issue":"5","key":"4928_CR28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41577-022-00815-z","volume":"23","author":"FR Carbone","year":"2023","unstructured":"Carbone FR (2023) Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases. Nat Rev Immunol 23(5):329\u2013335","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"4928_CR29","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1093\/infdis\/jiac296","volume":"227","author":"MC Cassetti","year":"2023","unstructured":"Cassetti MC, Pierson TC, Patterson LJ, Bok K, DeRocco AJ, Deschamps AM et al (2023) Prototype pathogen approach for vaccine and monoclonal antibody development: a critical component of the NIAID plan for pandemic preparedness. J Infect Dis 227(12):1433\u201341","journal-title":"J Infect Dis"},{"issue":"10","key":"4928_CR30","doi-asserted-by":"publisher","first-page":"e20200206","DOI":"10.1084\/jem.20200206","volume":"217","author":"A Cassotta","year":"2020","unstructured":"Cassotta A, Paparoditis P, Geiger R, Mettu RR, Landry SJ, Donati A et al (2020) Deciphering and predicting CD4\u2009+\u2009T cell immunodominance of influenza virus hemagglutinin. J Exp Med 217(10):e20200206","journal-title":"J Exp Med"},{"issue":"2","key":"4928_CR31","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.vaccine.2022.12.005","volume":"41","author":"S Chiba","year":"2023","unstructured":"Chiba S, Hatta M, Pattinson D, Yasuhara A, Neumann G, Kawaoka Y (2023) Ferret model to mimic the sequential exposure of humans to historical H3N2 influenza viruses. Vaccine 41(2):590\u2013597","journal-title":"Vaccine"},{"issue":"1","key":"4928_CR32","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s42003-023-04899-8","volume":"6","author":"W Chour","year":"2023","unstructured":"Chour W, Choi J, Xie J, Chaffee ME, Schmitt TM, Finton K et al (2023) Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8\u2009+\u2009T cell discovery and analysis. Commun Biol 6(1):528","journal-title":"Commun Biol"},{"issue":"2","key":"4928_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines6020018","volume":"6","author":"EB Clemens","year":"2018","unstructured":"Clemens EB, Van de Sandt C, Wong SS, Wakim LM, Valkenburg SA (2018) Harnessing the power of T cells: the promising hope for a universal influenza vaccine. Vaccines 6(2):18","journal-title":"Vaccines"},{"issue":"2","key":"4928_CR34","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3390\/vaccines3020293","volume":"3","author":"L Coughlan","year":"2015","unstructured":"Coughlan L, Lambe T (2015) Measuring cellular immunity to influenza: methods of detection, applications and challenges. Vaccines (Basel) 3(2):293\u2013319","journal-title":"Vaccines (Basel)"},{"key":"4928_CR35","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ebiom.2018.02.011","volume":"29","author":"L Coughlan","year":"2018","unstructured":"Coughlan L, Sridhar S, Payne R, Edmans M, Milicic A, Venkatraman N et al (2018) Heterologous two-dose vaccination with simian adenovirus and poxvirus vectors elicits long-lasting cellular immunity to influenza virus A in healthy adults. EBioMedicine 29:146\u2013154","journal-title":"EBioMedicine"},{"issue":"2","key":"4928_CR36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4161\/hv.22908","volume":"9","author":"R Cox","year":"2013","unstructured":"Cox R (2013) Correlates of protection to influenza virus, where do we go from here? Hum Vaccin Immunother 9(2):405\u2013408","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"4928_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-95479-9","volume":"15","author":"S Dam","year":"2025","unstructured":"Dam S, Tscherne A, Engels L, Sutter G, Osterhaus ADME, Rimmelzwaan GF (2025) Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8\u2009+\u2009T cell responses. Sci Rep 15(1):10586","journal-title":"Sci Rep"},{"key":"4928_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2025.08.005","author":"K Dhume","year":"2025","unstructured":"Dhume K, Finn CM, Baffoe E, Kimball LA, Annamalai SN, Urdaneta-P\u00e1ez V et al (2025) T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors. Mucosal Immunol. https:\/\/doi.org\/10.1016\/j.mucimm.2025.08.005","journal-title":"Mucosal Immunol"},{"key":"4928_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2025.100457","author":"Y Di","year":"2025","unstructured":"Di Y, Wang Z, Ren Z, Huang H, Yang S, Zhang C et al (2025) AT cell-based ubiquitin-mediated mRNA vaccine provides cross-protection against H1N1 and B influenza viruses in mice. Curr Res Microb Sci. https:\/\/doi.org\/10.1016\/j.crmicr.2025.100457","journal-title":"Curr Res Microb Sci"},{"key":"4928_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1483720","author":"Y Di","year":"2024","unstructured":"Di Y, Zhang C, Ren Z, Jiang R, Tang J, Yang S et al (2024) The self-assembled nanoparticle-based multi-epitope influenza mRNA vaccine elicits protective immunity against H1N1 and B influenza viruses in mice. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2024.1483720","journal-title":"Front Immunol"},{"issue":"9979","key":"4928_CR41","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/S0140-6736(14)62449-1","volume":"385","author":"J Dobson","year":"2015","unstructured":"Dobson J, Whitley RJ, Pocock S, Monto AS (2015) Oseltamivir treatment for influenza in adults: A meta-analysis of randomised controlled trials. Lancet 385(9979):1729\u20131737","journal-title":"Lancet"},{"key":"4928_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01378","author":"G Dolton","year":"2018","unstructured":"Dolton G, Zervoudi E, Rius C, Wall A, Thomas HL, Fuller A et al (2018) Optimized peptide\u2013MHC multimer protocols for detection and isolation of autoimmune T-Cells. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2018.01378","journal-title":"Front Immunol"},{"issue":"1","key":"4928_CR43","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1038\/s41467-024-50087-5","volume":"15","author":"C Dong","year":"2024","unstructured":"Dong C, Zhu W, Wei L, Kim JK, Ma Y, Kang SM et al (2024) Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines. Nat Commun 15(1):5800","journal-title":"Nat Commun"},{"key":"4928_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1751463","volume":"17","author":"S Dong","year":"2026","unstructured":"Dong S, Liu Z, Wang Z, Peng X, Huang Q, Yang H, Lei Y, Yao C (2026) Experimental study on synergistic pulses improving the tumor microenvironment and assisting immunotherapy. Front Immunol 17:1751463. https:\/\/doi.org\/10.3389\/fimmu.2026.1751463","journal-title":"Front Immunol"},{"key":"4928_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02312","volume":"9","author":"W Dong","year":"2018","unstructured":"Dong W, Bhide Y, Sicca F, Meijerhof T, Guilfoyle K, Engelhardt OG et al (2018) Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines. Front Immunol 9:2312","journal-title":"Front Immunol"},{"key":"4928_CR46","doi-asserted-by":"publisher","unstructured":"Duan S, Thomas PG (2016) Balancing Immune Protection and Immune Pathology by CD8\u2009+\u2009T-Cell Responses to Influenza Infection. Front Immunol 7. https:\/\/doi.org\/10.3389\/fimmu.2016.00025","DOI":"10.3389\/fimmu.2016.00025"},{"issue":"36","key":"4928_CR47","doi-asserted-by":"publisher","first-page":"5371","DOI":"10.1016\/j.vaccine.2019.07.033","volume":"37","author":"CS Eickhoff","year":"2019","unstructured":"Eickhoff CS, Terry FE, Peng L, Meza KA, Sakala IG, Van Aartsen D et al (2019) Highly conserved influenza T cell epitopes induce broadly protective immunity. Vaccine 37(36):5371\u201381","journal-title":"Vaccine"},{"issue":"1","key":"4928_CR48","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/s41467-022-29416-z","volume":"13","author":"D Ellis","year":"2022","unstructured":"Ellis D, Lederhofer J, Acton OJ, Tsybovsky Y, Kephart S, Yap C et al (2022) Structure-based design of stabilized recombinant influenza neuraminidase tetramers. Nat Commun 13(1):1825","journal-title":"Nat Commun"},{"issue":"12","key":"4928_CR50","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1093\/aje\/kwy145","volume":"187","author":"SL Epstein","year":"2018","unstructured":"Epstein SL (2018) Universal influenza vaccines: progress in achieving broad cross-protection in vivo. Am J Epidemiol 187(12):2603\u20132614","journal-title":"Am J Epidemiol"},{"issue":"46\u201347","key":"4928_CR49","doi-asserted-by":"publisher","first-page":"5404","DOI":"10.1016\/j.vaccine.2005.04.047","volume":"23","author":"SL Epstein","year":"2005","unstructured":"Epstein SL, Kong W, pui, Misplon JA, Lo CY, Tumpey TM, Xu L et al (2005) Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 23(46\u201347):5404\u20135410","journal-title":"Vaccine"},{"issue":"3","key":"4928_CR51","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/infdis\/jiy103","volume":"218","author":"EJ Erbelding","year":"2018","unstructured":"Erbelding EJ, Post DJ, Stemmy EJ, Roberts PC, Augustine AD, Ferguson S et al (2018) A universal influenza vaccine: the strategic plan for the National Institute of Allergy and Infectious Diseases. J Infect Dis 218(3):347\u2013354","journal-title":"J Infect Dis"},{"issue":"6","key":"4928_CR53","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S1473-3099(21)00702-7","volume":"22","author":"TG Evans","year":"2022","unstructured":"Evans TG, Bussey L, Eagling-Vose E, Rutkowski K, Ellis C, Argent C et al (2022) Efficacy and safety of a universal influenza A vaccine (MVA-NP+ M1) in adults when given after seasonal quadrivalent influenza vaccine immunisation (FLU009): a phase 2b, randomised, double-blind trial. Lancet Infect Dis 22(6):857\u2013866","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"4928_CR52","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S2666-5247(24)00024-7","volume":"5","author":"TG Evans","year":"2024","unstructured":"Evans TG, Castellino F, Dobczyk MK, Tucker G, Walley AM, Van Leuven K et al (2024) Assessment of CD8\u2009+\u2009T-cell mediated immunity in an influenza A (H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study. Lancet Microbe 5(7):645\u2013654","journal-title":"Lancet Microbe"},{"issue":"7","key":"4928_CR54","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3390\/cells13070639","volume":"13","author":"CM Finn","year":"2024","unstructured":"Finn CM, McKinstry KK (2024) Ex pluribus unum: the CD4 T cell response against influenza A virus. Cells 13(7):639","journal-title":"Cells"},{"issue":"7","key":"4928_CR55","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1128\/CVI.00397-07","volume":"15","author":"BD Forrest","year":"2008","unstructured":"Forrest BD, Pride MW, Dunning AJ, Capeding MRZ, Chotpitayasunondh T, Tam JS et al (2008) Correlation of cellular immune responses with protection against culture-confirmed influenza virus in young children. Clin Vaccine Immunol 15(7):1042\u20131053","journal-title":"Clin Vaccine Immunol"},{"key":"4928_CR56","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1126\/science.aav5095","volume":"364","author":"G Gaiha","year":"2019","unstructured":"Gaiha G, Rossin E, Urbach J, Landeros C, Collins D, Nwonu C et al (2019) Structural topology defines protective CD8\u2009+\u2009T cell epitopes in the HIV proteome. Science 364:480\u20134. https:\/\/doi.org\/10.1126\/science.aav5095","journal-title":"Science"},{"issue":"10454","key":"4928_CR57","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S0140-6736(24)01307-2","volume":"404","author":"Y Gao","year":"2024","unstructured":"Gao Y, Guyatt G, Uyeki TM, Liu M, Chen Y, Zhao Y et al (2024) Antivirals for treatment of severe influenza: A systematic review and network meta-analysis of randomised controlled trials. Lancet 404(10454):753\u201363","journal-title":"Lancet"},{"issue":"11","key":"4928_CR58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.00246-17","volume":"91","author":"T Gerlach","year":"2017","unstructured":"Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C et al (2017) pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs. J Virol 91(11):10\u20131128","journal-title":"J Virol"},{"issue":"1","key":"4928_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4049-5","volume":"19","author":"PB Gilbert","year":"2019","unstructured":"Gilbert PB, Fong Y, Juraska M, Carpp LN, Monto AS, Martin ET et al (2019) HAI and NAI titer correlates of inactivated and live attenuated influenza vaccine efficacy. BMC Infect Dis 19(1):453","journal-title":"BMC Infect Dis"},{"issue":"12","key":"4928_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008109","volume":"15","author":"KM Gostic","year":"2019","unstructured":"Gostic KM, Bridge R, Brady S, Viboud C, Worobey M, Lloyd-Smith JO (2019) Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics. PLoS Pathog 15(12):e1008109","journal-title":"PLoS Pathog"},{"key":"4928_CR61","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1146\/annurev-virology-010320-044746","volume":"7","author":"S Gouma","year":"2020","unstructured":"Gouma S, Anderson EM, Hensley SE (2020) Challenges of making effective influenza vaccines. Annu Rev Virol 7:495\u2013512","journal-title":"Annu Rev Virol"},{"issue":"11","key":"4928_CR62","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.70017","volume":"13","author":"EJ Grant","year":"2024","unstructured":"Grant EJ, Gras S (2024) CD 8\u2009+\u2009T cell epitope conservation in emerging H 5 N 1 viruses suggests global protection. Clin Transl Immunology 13(11):e70017","journal-title":"Clin Transl Immunology"},{"issue":"1","key":"4928_CR63","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1038\/s41467-018-07815-5","volume":"9","author":"EJ Grant","year":"2018","unstructured":"Grant EJ, Josephs TM, Loh L, Clemens EB, Sant S, Bharadwaj M et al (2018) Broad CD8\u2009+\u2009T cell cross-recognition of distinct influenza A strains in humans. Nat Commun 9(1):5427","journal-title":"Nat Commun"},{"issue":"9","key":"4928_CR64","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.micinf.2008.07.002","volume":"10","author":"KM Grebe","year":"2008","unstructured":"Grebe KM, Yewdell JW, Bennink JR (2008) Heterosubtypic immunity to influenza A virus: where do we stand? Microbes Infect 10(9):1024\u20131029","journal-title":"Microbes Infect"},{"key":"4928_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107885","author":"A Greenshields-Watson","year":"2020","unstructured":"Greenshields-Watson A, Attaf M, MacLachlan BJ, Whalley T, Rius C, Wall A et al (2020) CD4\u2009+\u2009T cells recognize conserved influenza A epitopes through shared patterns of V-gene usage and complementary biochemical features. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2020.107885","journal-title":"Cell Rep"},{"key":"4928_CR66","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7432a2","author":"LA Grohskopf","year":"2025","unstructured":"Grohskopf LA (2025) Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2025\u201326 influenza season. MMWR Morb Mortal Wkly Rep. https:\/\/doi.org\/10.15585\/mmwr.mm7432a2","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"4928_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7774\/cevr.2015.4.1.1","volume":"4","author":"T Grunwald","year":"2015","unstructured":"Grunwald T, Ulbert S (2015) Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases. Clin Exp Vaccine Res 4(1):1\u201310","journal-title":"Clin Exp Vaccine Res"},{"issue":"6","key":"4928_CR68","doi-asserted-by":"publisher","first-page":"2600070","DOI":"10.2807\/1560-7917.ES.2026.31.6.2600070","volume":"31","author":"R Guiomar","year":"2026","unstructured":"Guiomar R, Henriques C, da Silva SP, Gomes L, Dias D, Verdasca N et al (2026) Cross-sectional study on protective antibodies against influenza A virus subtypes and cross-protection against influenza A (H3N2) subclade K, Portugal, August 2025. Eurosurveillance 31(6):2600070","journal-title":"Eurosurveillance"},{"issue":"1","key":"4928_CR69","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s43141-023-00581-y","volume":"21","author":"D Gupta","year":"2023","unstructured":"Gupta D, Mohan S (2023) Influenza vaccine: A review on current scenario and future prospects. J Genet Eng Biotechnol 21(1):154","journal-title":"J Genet Eng Biotechnol"},{"issue":"1","key":"4928_CR70","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2024.2306959","volume":"13","author":"H Hamza","year":"2024","unstructured":"Hamza H, Ghosh M, L\u00f6ffler MW, Rammensee HG, Planz O (2024) Identification and relative abundance of naturally presented and cross-reactive influenza A virus MHC class I-restricted T cell epitopes. Emerg Microbes Infect 13(1):2306959","journal-title":"Emerg Microbes Infect"},{"issue":"5","key":"4928_CR71","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s12276-021-00603-0","volume":"53","author":"WN Harrington","year":"2021","unstructured":"Harrington WN, Kackos CM, Webby RJ (2021) The evolution and future of influenza pandemic preparedness. Exp Mol Med 53(5):737\u2013749","journal-title":"Exp Mol Med"},{"key":"4928_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1039194","volume":"13","author":"M Hassert","year":"2022","unstructured":"Hassert M, Harty JT (2022) Tissue resident memory T cells-a new benchmark for the induction of vaccine-induced mucosal immunity. Front Immunol 13:1039194","journal-title":"Front Immunol"},{"issue":"5","key":"4928_CR73","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/irv.12565","volume":"12","author":"AJ Hay","year":"2018","unstructured":"Hay AJ, McCauley JW (2018) The WHO global influenza surveillance and response system (GISRS)\u2014a future perspective. Influenza Other Respir Viruses 12(5):551\u2013557","journal-title":"Influenza Other Respir Viruses"},{"key":"4928_CR103","doi-asserted-by":"crossref","unstructured":"Heath J, Chour W, Choi J, Xie J, Chaffee M, Schmitt T et al (2022) Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8\u2009+\u2009T cell discovery and analysis. Res Sq. ;rs\u20133","DOI":"10.21203\/rs.3.rs-1090664\/v1"},{"issue":"11","key":"4928_CR74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001190","volume":"2","author":"AT Heiny","year":"2007","unstructured":"Heiny AT, Miotto O, Srinivasan KN, Khan AM, Zhang GL, Brusic V et al (2007) Evolutionarily conserved protein sequences of influenza A viruses, avian and human, as vaccine targets. PLoS One 2(11):e1190","journal-title":"PLoS One"},{"key":"4928_CR8","doi-asserted-by":"crossref","unstructured":"Henry C, Makrinos D, Liu R, Cavallaro M, Fenderson B, Sun Y et al (2026) An mRNA influenza vaccine induces immunity comparable to an adjuvanted vaccine in a randomized trial. NPJ Vaccines","DOI":"10.1038\/s41541-026-01370-7"},{"issue":"1","key":"4928_CR75","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.it.2017.08.003","volume":"39","author":"C Henry","year":"2018","unstructured":"Henry C, Palm AKE, Krammer F, Wilson PC (2018) From original antigenic sin to the universal influenza virus vaccine. Trends Immunol 39(1):70\u201379","journal-title":"Trends Immunol"},{"issue":"1","key":"4928_CR76","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1038\/s41467-021-23212-x","volume":"12","author":"L Hensen","year":"2021","unstructured":"Hensen L, Illing PT, Bridie Clemens E, Nguyen THO, Koutsakos M, van de Sandt CE et al (2021) CD8\u2009+\u2009T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A* 24: 02 allomorph. Nat Commun 12(1):2931","journal-title":"Nat Commun"},{"key":"4928_CR77","doi-asserted-by":"publisher","first-page":"812393","DOI":"10.3389\/fimmu.2022.812393","volume":"13","author":"L Hensen","year":"2022","unstructured":"Hensen L, Illing PT, Rowntree LC, Davies J, Miller A, Tong SYC et al (2022) T cell epitope discovery in the context of distinct and unique indigenous HLA profiles. Front Immunol 13:812393","journal-title":"Front Immunol"},{"issue":"1","key":"4928_CR78","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41541-024-00874-4","volume":"9","author":"Y Hou","year":"2024","unstructured":"Hou Y, Chen M, Bian Y, Hu Y, Chuan J, Zhong L et al (2024) Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies. NPJ Vaccines 9(1):77","journal-title":"NPJ Vaccines"},{"key":"4928_CR80","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.virol.2016.10.027","volume":"500","author":"I Isakova-Sivak","year":"2017","unstructured":"Isakova-Sivak I, Korenkov D, Smolonogina T, Tretiak T, Donina S, Rekstin A et al (2017) Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model. Virology 500:209\u2013217","journal-title":"Virology"},{"issue":"10127","key":"4928_CR81","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","volume":"391","author":"AD Iuliano","year":"2018","unstructured":"Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S et al (2018) Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet 391(10127):1285\u20131300","journal-title":"Lancet"},{"key":"4928_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2024.199355","volume":"343","author":"JM Jansen","year":"2024","unstructured":"Jansen JM, Meineke R, Molle A, van de Sandt CE, Saletti G, Rimmelzwaan GF (2024) Selective pressure mediated by influenza virus M158\u201366 epitope-specific CD8\u2009+\u2009T cells promotes accumulation of extra-epitopic amino acid substitutions associated with viral resistance to these T cells. Virus Res 343:199355","journal-title":"Virus Res"},{"key":"4928_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.959379","volume":"13","author":"Y Janssens","year":"2022","unstructured":"Janssens Y, Joye J, Waerlop G, Clement F, Leroux-Roels G, Leroux-Roels I (2022) The role of cell-mediated immunity against influenza and its implications for vaccine evaluation. Front Immunol 13:959379","journal-title":"Front Immunol"},{"issue":"5","key":"4928_CR84","doi-asserted-by":"publisher","first-page":"669","DOI":"10.2105\/AJPH.2019.305557","volume":"110","author":"BJ Jester","year":"2020","unstructured":"Jester BJ, Uyeki TM, Jernigan DB (2020) Fifty years of influenza A (H3N2) following the pandemic of 1968. Am J Public Health 110(5):669\u2013676","journal-title":"Am J Public Health"},{"issue":"2","key":"4928_CR85","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2217076","volume":"19","author":"Y Jia","year":"2023","unstructured":"Jia Y, Fu B, Dong L, Zhao M (2023) Sweet syndrome induced by SARS-CoV-2 vaccines: a systematic review of patient-report studies. Hum Vaccin Immunother 19(2):2217076. https:\/\/doi.org\/10.1080\/21645515.2023.2217076","journal-title":"Hum Vaccin Immunother"},{"issue":"2","key":"4928_CR86","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41564-024-01903-7","volume":"10","author":"S Kalimuddin","year":"2025","unstructured":"Kalimuddin S, Tham CYL, Chan YFZ, Hang SK, Kunasegaran K, Chia A et al (2025) Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans. Nat Microbiol 10(2):374\u201387","journal-title":"Nat Microbiol"},{"issue":"6","key":"4928_CR87","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.medj.2021.04.003","volume":"2","author":"S Kalimuddin","year":"2021","unstructured":"Kalimuddin S, Tham CYL, Qui M, de Alwis R, Sim JXY, Lim JME et al (2021) Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset. Med 2(6):682-688.e4. https:\/\/doi.org\/10.1016\/j.medj.2021.04.003","journal-title":"Med"},{"issue":"10","key":"4928_CR88","doi-asserted-by":"publisher","first-page":"e136653","DOI":"10.1172\/jci.insight.136653","volume":"5","author":"HG Kelly","year":"2020","unstructured":"Kelly HG, Tan HX, Juno JA, Esterbauer R, Ju Y, Jiang W et al (2020) Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation. JCI Insight 5(10):e136653","journal-title":"JCI Insight"},{"issue":"7","key":"4928_CR89","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1073\/pnas.1423482112","volume":"112","author":"DB Keskin","year":"2015","unstructured":"Keskin DB, Reinhold BB, Zhang GL, Ivanov AR, Karger BL, Reinherz EL (2015) Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity. Proc Natl Acad Sci U S A 112(7):2151\u20136","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"4928_CR90","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1089\/vim.2017.0141","volume":"31","author":"H Kim","year":"2018","unstructured":"Kim H, Webster RG, Webby RJ (2018) Influenza virus: dealing with a drifting and shifting pathogen. Viral Immunol 31(2):174\u2013183","journal-title":"Viral Immunol"},{"issue":"3","key":"4928_CR91","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.4110\/in.2024.24.e19","volume":"24","author":"SH Kim","year":"2024","unstructured":"Kim SH, Espa\u00f1o E, Padasas BT, Son JH, Oh J, Webby RJ et al (2024) Influenza virus-derived CD8 T cell epitopes: implications for the development of Universal Influenza Vaccines. Immune Netw 24(3):e19","journal-title":"Immune Netw"},{"key":"4928_CR92","doi-asserted-by":"publisher","first-page":"559382","DOI":"10.3389\/fimmu.2020.559382","volume":"11","author":"B Kingstad-Bakke","year":"2021","unstructured":"Kingstad-Bakke B, Toy R, Lee W, Pradhan P, Vogel G, Marinaik CB et al (2021) Polymeric pathogen-like particles-based combination adjuvants elicit potent mucosal T cell immunity to influenza A virus. Front Immunol 11:559382","journal-title":"Front Immunol"},{"issue":"12","key":"4928_CR94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189780","volume":"12","author":"MT Koday","year":"2017","unstructured":"Koday MT, Leonard JA, Munson P, Forero A, Koday M, Bratt DL et al (2017) Multigenic DNA vaccine induces protective cross-reactive T cell responses against heterologous influenza virus in nonhuman primates. PLoS One 12(12):e0189780","journal-title":"PLoS One"},{"issue":"1","key":"4928_CR93","doi-asserted-by":"publisher","first-page":"10368","DOI":"10.1038\/s41467-024-54620-4","volume":"15","author":"KH Ko","year":"2024","unstructured":"Ko KH, Bae HS, Park JW, Lee JS, Park S, Heo J et al (2024) A vaccine platform targeting lung-resident memory CD4\u2009+\u2009T-cells provides protection against heterosubtypic influenza infections in mice and ferrets. Nat Commun 15(1):10368","journal-title":"Nat Commun"},{"issue":"4","key":"4928_CR95","doi-asserted-by":"publisher","DOI":"10.4110\/in.2023.23.e32","volume":"23","author":"HJ Kong","year":"2023","unstructured":"Kong HJ, Choi Y, Kim EA, Chang J (2023) Vaccine strategy that enhances the protective efficacy of systemic immunization by establishing lung-resident memory CD8 T cells against influenza infection. Immune Netw 23(4):e32","journal-title":"Immune Netw"},{"issue":"10","key":"4928_CR96","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1093\/cid\/ciy327","volume":"67","author":"M Kosikova","year":"2018","unstructured":"Kosikova M, Li L, Radvak P, Ye Z, Wan XF, Xie H (2018) Imprinting of repeated influenza A\/H3 exposures on antibody quantity and antibody quality: implications for seasonal vaccine strain selection and vaccine performance. Clin Infect Dis 67(10):1523\u20131532","journal-title":"Clin Infect Dis"},{"issue":"5","key":"4928_CR97","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41590-019-0320-6","volume":"20","author":"M Koutsakos","year":"2019","unstructured":"Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S et al (2019) Human CD8\u2009+\u2009T cell cross-reactivity across influenza A, B and C viruses. Nat Immunol 20(5):613\u201325","journal-title":"Nat Immunol"},{"issue":"10","key":"4928_CR98","doi-asserted-by":"publisher","first-page":"e13314","DOI":"10.1111\/irv.13314","volume":"18","author":"F Krammer","year":"2024","unstructured":"Krammer F, Katz JM, Engelhardt OG, Post DJ, Roberts PC, Sullivan SG et al (2024) Meeting Report From Correlates of Protection for Next Generation Influenza Vaccines: Lessons Learned From the COVID-19 Pandemic. Influenza Other Respir Viruses 18(10):e13314","journal-title":"Influenza Other Respir Viruses"},{"issue":"11","key":"4928_CR99","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.1128\/JVI.07158-11","volume":"86","author":"JC Krause","year":"2012","unstructured":"Krause JC, Tsibane T, Tumpey TM, Huffman CJ, Albrecht R, Blum DL et al (2012) Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses. J Virol 86(11):6334\u20136340","journal-title":"J Virol"},{"issue":"1","key":"4928_CR100","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/22221751.2019.1581034","volume":"8","author":"JCC Lai","year":"2019","unstructured":"Lai JCC, Karunarathna HMTK, Wong HH, Peiris JSM, Nicholls JM (2019) Neuraminidase activity and specificity of influenza A virus are influenced by haemagglutinin-receptor binding. Emerg Microbes Infect 8(1):327\u2013338","journal-title":"Emerg Microbes Infect"},{"key":"4928_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.127677","author":"A Lane","year":"2025","unstructured":"Lane A, Quach HQ, Ovsyannikova IG, Kennedy RB, Ross TM, Einav T (2025) High-resolution antibody dynamics following influenza vaccination reveal predominantly weak responses as well as infrequent but durable immunity across the 2014\u20132022 seasons. Vaccine. https:\/\/doi.org\/10.1016\/j.vaccine.2025.127677","journal-title":"Vaccine"},{"issue":"1","key":"4928_CR102","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41541-023-00705-y","volume":"8","author":"J Lanfermeijer","year":"2023","unstructured":"Lanfermeijer J, van de Ven K, van Dijken H, Hendriks M, Talavera Orme\u00f1o CMP, de Heij F et al (2023) Modified influenza M158\u201366 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge. NPJ Vaccines 8(1):116","journal-title":"NPJ Vaccines"},{"issue":"3","key":"4928_CR104","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.immuni.2024.02.003","volume":"57","author":"J Lederhofer","year":"2024","unstructured":"Lederhofer J, Tsybovsky Y, Nguyen L, Raab JE, Creanga A, Stephens T et al (2024) Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase. Immunity 57(3):574-586.e7. https:\/\/doi.org\/10.1016\/j.immuni.2024.02.003","journal-title":"Immunity"},{"key":"4928_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2024.101397","volume":"65","author":"S Lee","year":"2024","unstructured":"Lee S, Yeung KKM, Watts TH (2024) Tissue-resident memory T cells in protective immunity to influenza virus. Curr Opin Virol 65:101397","journal-title":"Curr Opin Virol"},{"issue":"9","key":"4928_CR109","doi-asserted-by":"publisher","first-page":"e1010875","DOI":"10.1371\/journal.ppat.1010875","volume":"18","author":"W Liang","year":"2022","unstructured":"Liang W, Tan TJC, Wang Y, Lv H, Sun Y, Bruzzone R et al (2022) Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution. PLoS Pathog 18(9):e1010875","journal-title":"PLoS Pathog"},{"issue":"1","key":"4928_CR110","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/cid\/cis327","volume":"55","author":"PJ Lillie","year":"2012","unstructured":"Lillie PJ, Berthoud TK, Powell TJ, Lambe T, Mullarkey C, Spencer AJ et al (2012) Preliminary assessment of the efficacy of a t-cell\u2013based influenza vaccine, MVA-NP+ M1, in humans. Clin Infect Dis 55(1):19\u201325","journal-title":"Clin Infect Dis"},{"issue":"3","key":"4928_CR111","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13276","volume":"18","author":"CML Lim","year":"2024","unstructured":"Lim CML, Komarasamy TV, Adnan NAAB, Radhakrishnan AK, Balasubramaniam VRMT (2024) Recent advances, approaches and challenges in the development of universal influenza vaccines. Influenza Other Respir Viruses 18(3):e13276","journal-title":"Influenza Other Respir Viruses"},{"issue":"1","key":"4928_CR108","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s44149-025-00187-6","volume":"5","author":"M Li","year":"2025","unstructured":"Li M, Guo P, Song H, Chen C, Zhou H, Tao P (2025) Development of universal influenza vaccines: strategies for broadly cross-reactive influenza vaccine responses. Anim Dis 5(1):33","journal-title":"Anim Dis"},{"issue":"18","key":"4928_CR106","doi-asserted-by":"publisher","first-page":"10016","DOI":"10.1128\/JVI.01129-13","volume":"87","author":"Q Li","year":"2013","unstructured":"Li Q, Qi J, Wu Y, Kiyota H, Tanaka K, Suhara Y et al (2013) Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance. J Virol 87(18):10016\u201310024","journal-title":"J Virol"},{"issue":"40","key":"4928_CR112","doi-asserted-by":"publisher","first-page":"17175","DOI":"10.1073\/pnas.0906849106","volume":"106","author":"J Liu","year":"2009","unstructured":"Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ et al (2009) Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957. Proceedings of the National Academy of Sciences 106(40):17175\u201380","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"4928_CR114","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1002\/eji.201343417","volume":"43","author":"J Liu","year":"2013","unstructured":"Liu J, Wu B, Zhang S, Tan S, Sun Y, Chen Z et al (2013) Conserved epitopes dominate cross-CD 8\u2009+\u2009T\u2010cell responses against influenza AH 1\u00a0N 1 virus among A sian populations. Eur J Immunol 43(8):2055\u20132069","journal-title":"Eur J Immunol"},{"key":"4928_CR113","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58504-z","author":"Y Liu","year":"2025","unstructured":"Liu Y, Deng S, Ren S, Tam RCY, Liu S, Zhang AJ et al (2025) Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-025-58504-z","journal-title":"Nat Commun"},{"issue":"2","key":"4928_CR107","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9020075","volume":"9","author":"Z Li","year":"2021","unstructured":"Li Z, Zhao Y, Li Y, Chen X (2021) Adjuvantation of influenza vaccines to induce cross-protective immunity. Vaccines (Basel) 9(2):75","journal-title":"Vaccines (Basel)"},{"issue":"3","key":"4928_CR115","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030434","volume":"8","author":"CE Lopez","year":"2020","unstructured":"Lopez CE, Legge KL (2020) Influenza A virus vaccination: immunity, protection, and recent advances toward a universal vaccine. Vaccines (Basel) 8(3):434","journal-title":"Vaccines (Basel)"},{"key":"4928_CR116","doi-asserted-by":"publisher","first-page":"1332939","DOI":"10.3389\/fimmu.2024.1332939","volume":"15","author":"B Lu","year":"2024","unstructured":"Lu B, Lim JM, Yu B, Song S, Neeli P, Sobhani N et al (2024) The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects. Front Immunol 15:1332939","journal-title":"Front Immunol"},{"key":"4928_CR117","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJM198307073090103","volume":"309","author":"AJ M","year":"1983","unstructured":"M AJ (1983) Cytotoxic t-cell immunity to influenza. N Engl J Med 309:13\u20137","journal-title":"N Engl J Med"},{"key":"4928_CR120","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179230","author":"VF Malavet","year":"2025","unstructured":"Malavet VF, Dhume K, Satchmei A, Arvelo AC, Beaird AJ, Annamalai SN et al (2025) Preexisting vaccine-primed heterosubtypic T cell immunity protects the maternal-fetal unit from adverse influenza outcomes in mice. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI179230","journal-title":"J Clin Invest"},{"key":"4928_CR121","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04581-6","author":"A Maleki","year":"2022","unstructured":"Maleki A, Russo G, Parasiliti Palumbo GA, Pappalardo F (2022) In silico design of recombinant multi-epitope vaccine against influenza A virus. BMC Bioinformatics. https:\/\/doi.org\/10.1186\/s12859-022-04581-6","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"4928_CR122","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00306-7","volume":"6","author":"AC Marriott","year":"2021","unstructured":"Marriott AC, Gooch KE, Brown PJ, Ryan KA, Jones NJ, Merredew N et al (2021) Severity of heterosubtypic influenza virus infection in ferrets is reduced by live attenuated influenza vaccine. NPJ Vaccines 6(1):43","journal-title":"NPJ Vaccines"},{"issue":"12","key":"4928_CR123","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1016\/j.immuni.2025.11.003","volume":"58","author":"CLR Mattingly","year":"2025","unstructured":"Mattingly CLR, Jimenez AR, Williams ME, Kost KN, Lawrence LA, Chen TD et al (2025) Human lung CD8\u2009+\u2009tissue-resident memory T cell-derived interferon-\u03b3 orchestrates subset-specific antiviral programming in airway epithelial cells. Immunity 58(12):3006\u20133023","journal-title":"Immunity"},{"issue":"52","key":"4928_CR118","doi-asserted-by":"publisher","first-page":"20949","DOI":"10.1073\/pnas.0710286104","volume":"104","author":"W Ma","year":"2007","unstructured":"Ma W, Vincent AL, Gramer MR, Brockwell CB, Lager KM, Janke BH et al (2007) Identification of H2N3 influenza A viruses from swine in the United States. Proc Natl Acad Sci U S A 104(52):20949\u201354","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4928_CR119","doi-asserted-by":"publisher","first-page":"126670","DOI":"10.1016\/j.vaccine.2024.126670","volume":"46","author":"Y Ma","year":"2025","unstructured":"Ma Y, Dong C, Kim JK, Zhu W, Wei L, Wang Y et al (2025) Impact of influenza immune imprinting on immune responses to subsequent vaccinations in mice. Vaccine 46:126670","journal-title":"Vaccine"},{"issue":"14","key":"4928_CR124","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/S0264-410X(94)80063-6","volume":"12","author":"IN Mbawuike","year":"1994","unstructured":"Mbawuike IN, Dillon SB, Demuth SG, Jones CS, Cate TR, Couch RB (1994) Influenza A subtype cross-protection after immunization of outbred mice with a purified chimeric NS1\/HA2 influenza virus protein. Vaccine 12(14):1340\u20131348","journal-title":"Vaccine"},{"key":"4928_CR125","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fmicb.2019.00039","volume":"10","author":"JL McAuley","year":"2019","unstructured":"McAuley JL, Gilbertson BP, Trifkovic S, Brown LE, McKimm-Breschkin JL (2019) Influenza virus neuraminidase structure and functions. Front Microbiol 10:39","journal-title":"Front Microbiol"},{"issue":"6","key":"4928_CR126","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1002\/jmv.27662","volume":"94","author":"MC McGee","year":"2022","unstructured":"McGee MC, Huang W (2022) Evolutionary conservation and positive selection of influenza A nucleoprotein CTL epitopes for universal vaccination. J Med Virol 94(6):2578\u20132587","journal-title":"J Med Virol"},{"issue":"12","key":"4928_CR127","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1016\/j.chom.2021.10.009","volume":"29","author":"DR McIlwain","year":"2021","unstructured":"McIlwain DR, Chen H, Rahil Z, Bidoki NH, Jiang S, Bjornson Z et al (2021) Human influenza virus challenge identifies cellular correlates of protection for oral vaccination. Cell Host Microbe 29(12):1828\u20131837","journal-title":"Cell Host Microbe"},{"issue":"9","key":"4928_CR128","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1038\/s41590-023-01590-2","volume":"24","author":"RC Mettelman","year":"2023","unstructured":"Mettelman RC, Souquette A, Van de Velde LA, Vegesana K, Allen EK, Kackos CM et al (2023) Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Nat Immunol 24(9):1511\u20131526","journal-title":"Nat Immunol"},{"issue":"9","key":"4928_CR129","doi-asserted-by":"publisher","first-page":"962","DOI":"10.3390\/vaccines13090962","volume":"13","author":"VR Mokalla","year":"2025","unstructured":"Mokalla VR, Gundarapu S, Kaushik RS, Rajput M, Tummala H (2025) Influenza vaccines: current status, adjuvant strategies, and efficacy. Vaccines (Basel) 13(9):962","journal-title":"Vaccines (Basel)"},{"key":"4928_CR130","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74438-w","author":"L Momajadi","year":"2024","unstructured":"Momajadi L, Khanahmad H, Mahnam K (2024) Designing a multi-epitope influenza vaccine: an immunoinformatics approach. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-024-74438-w","journal-title":"Sci Rep"},{"issue":"Supplement6","key":"4928_CR131","doi-asserted-by":"publisher","first-page":"S460","DOI":"10.1093\/infdis\/jiad267","volume":"228","author":"KM Morabito","year":"2023","unstructured":"Morabito KM, Cassetti MC, DeRocco AJ, Deschamps AM, Pierson TC (2023) Viral prototypes for pandemic preparedness: the road ahead. J Infect Dis 228(Supplement6):S460\u2013S464","journal-title":"J Infect Dis"},{"issue":"10","key":"4928_CR132","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41577-024-01030-8","volume":"24","author":"TR Mosmann","year":"2024","unstructured":"Mosmann TR, McMichael AJ, LeVert A, McCauley JW, Almond JW (2024) Opportunities and challenges for T cell-based influenza vaccines. Nat Rev Immunol 24(10):736\u2013752","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"4928_CR133","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41591-020-1118-7","volume":"27","author":"R Nachbagauer","year":"2021","unstructured":"Nachbagauer R, Feser J, Naficy A, Bernstein DI, Guptill J, Walter EB et al (2021) A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial. Nat Med 27(1):106\u2013114","journal-title":"Nat Med"},{"issue":"2","key":"4928_CR134","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1089\/vim.2009.0099","volume":"23","author":"JL Nayak","year":"2010","unstructured":"Nayak JL, Richards KA, Chaves FA, Sant AJ (2010) Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol 23(2):169\u2013180","journal-title":"Viral Immunol"},{"issue":"5","key":"4928_CR135","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4049\/jimmunol.2200393","volume":"210","author":"T Ng","year":"2023","unstructured":"Ng T, Flores-Malavet V, Mansoor MAM, Arvelo AC, Dhume K, Prokop E et al (2023) Intermediate levels of pre-existing protective antibody allow priming of protective T cell immunity against influenza. J Immunol 210(5):628\u2013639","journal-title":"J Immunol"},{"issue":"1","key":"4928_CR136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009894","volume":"18","author":"B Nicholas","year":"2022","unstructured":"Nicholas B, Bailey A, Staples KJ, Wilkinson T, Elliott T, Skipp P (2022) Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands. PLoS Pathog 18(1):e1009894","journal-title":"PLoS Pathog"},{"issue":"2","key":"4928_CR137","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2217\/fvl.10.3","volume":"5","author":"MR Olson","year":"2010","unstructured":"Olson MR, Russ BE, Doherty PC, Turner SJ, Stambas J (2010) Influenza A virus-specific CD8\u2009+\u2009T-cell responses: from induction to function. Future Virol 5(2):175\u201383","journal-title":"Future Virol"},{"key":"4928_CR138","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.coviro.2020.02.003","volume":"40","author":"J Ostrowsky","year":"2020","unstructured":"Ostrowsky J, Arpey M, Moore K, Osterholm M, Friede M, Gordon J et al (2020) Tracking progress in universal influenza vaccine development. Curr Opin Virol 40:28\u201336","journal-title":"Curr Opin Virol"},{"issue":"5","key":"4928_CR139","doi-asserted-by":"publisher","first-page":"361","DOI":"10.5144\/0256-4947.2025.361","volume":"45","author":"AA Othman","year":"2025","unstructured":"Othman AA, Albargy H (2025) Humoral immune response to mRNA-based influenza vaccines in older adults: a systematic review and meta-analysis of randomized controlled trials. Ann Saudi Med 45(5):361\u2013371","journal-title":"Ann Saudi Med"},{"key":"4928_CR140","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.virol.2015.01.002","volume":"477","author":"C Pappas","year":"2015","unstructured":"Pappas C, Yang H, Carney PJ, Pearce MB, Katz JM, Stevens J et al (2015) Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets. Virology 477:61\u201371","journal-title":"Virology"},{"issue":"3","key":"4928_CR141","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00867-24","volume":"99","author":"H Park","year":"2025","unstructured":"Park H, Kingstad-Bakke B, Cleven T, Jung M, Kawaoka Y, Suresh M (2025) Diversifying T-cell responses: safeguarding against pandemic influenza with mosaic nucleoprotein. J Virol 99(3):e00867-24","journal-title":"J Virol"},{"issue":"9","key":"4928_CR142","doi-asserted-by":"publisher","first-page":"890","DOI":"10.3390\/vaccines13090890","volume":"13","author":"S Parvez","year":"2025","unstructured":"Parvez S, Pathrathota A, Uppar AL, Yadagiri G, Mudavath SL (2025) Influenza virus: global health impact, strategies, challenges, role of nanotechnolgy in influenza vaccine development. Vaccines (Basel) 13(9):890","journal-title":"Vaccines (Basel)"},{"key":"4928_CR143","doi-asserted-by":"publisher","first-page":"RP91849","DOI":"10.7554\/eLife.91849.3","volume":"13","author":"AC Perofsky","year":"2024","unstructured":"Perofsky AC, Huddleston J, Hansen CL, Barnes JR, Rowe T, Xu X et al (2024) Antigenic drift and subtype interference shape A (H3N2) epidemic dynamics in the United States. Elife 13:RP91849","journal-title":"Elife"},{"issue":"11","key":"4928_CR144","doi-asserted-by":"publisher","first-page":"6390","DOI":"10.4049\/jimmunol.1004031","volume":"186","author":"GV Petrova","year":"2011","unstructured":"Petrova GV, Naumova EN, Gorski J (2011) The polyclonal CD8 T cell response to influenza M158\u201366 generates a fully connected network of cross-reactive clonotypes to structurally related peptides: a paradigm for memory repertoire coverage of novel epitopes or escape mutants. J Immunol 186(11):6390\u20136397","journal-title":"J Immunol"},{"issue":"27","key":"4928_CR145","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","volume":"383","author":"P Pf","year":"2020","unstructured":"Pf P, Ts J, K N, A J, G A, L S et al (2020) Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 383(27):2603\u201315. https:\/\/doi.org\/10.1056\/NEJMoa2034577","journal-title":"N Engl J Med"},{"key":"4928_CR146","doi-asserted-by":"crossref","unstructured":"Pleguezuelos O, James E, Fernandez A, Lopes V, Rosas LA, Cervantes-Medina A et al (2020) Efficacy of FLU-v, a broad-spectrum influenza vaccine, in a randomized phase IIb human influenza challenge study. NPJ Vaccines 5(1):22","DOI":"10.1038\/s41541-020-0174-9"},{"issue":"5","key":"4928_CR147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062778","volume":"8","author":"TJ Powell","year":"2013","unstructured":"Powell TJ, Peng Y, Berthoud TK, Blais ME, Lillie PJ, Hill AVS et al (2013) Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+ M1 vaccine. PLoS One 8(5):e62778","journal-title":"PLoS One"},{"issue":"8","key":"4928_CR148","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1039\/d1nr08460g","volume":"14","author":"Y Qiao","year":"2022","unstructured":"Qiao Y, Li S, Jin S, Pan Y, Shi Y, Kong W et al (2022) A self-assembling nanoparticle vaccine targeting the conserved epitope of influenza virus hemagglutinin stem elicits a cross-protective immune response. Nanoscale 14(8):3250\u201360. https:\/\/doi.org\/10.1039\/d1nr08460g","journal-title":"Nanoscale"},{"key":"4928_CR149","doi-asserted-by":"publisher","unstructured":"Ranzani O, Neto F, Mareto L, Brumatti T, Oliveira R, Silva P et al (2025) Effectiveness of the TAK-003 dengue vaccine in adolescents during the 2024 outbreak in S\u00e3o Paulo, Brazil: a test-negative, case\u2013control study. Lancet Infect Dis 26. https:\/\/doi.org\/10.1016\/S1473-3099(25)00382-2","DOI":"10.1016\/S1473-3099(25)00382-2"},{"key":"4928_CR150","doi-asserted-by":"publisher","DOI":"10.1056\/nejmp2600395","author":"SA Rasmussen","year":"2026","unstructured":"Rasmussen SA, Jernigan DB (2026) Antigenic drift and antivaccine shift in the 2025\u20132026 influenza season. N Engl J Med. https:\/\/doi.org\/10.1056\/nejmp2600395","journal-title":"N Engl J Med"},{"issue":"1","key":"4928_CR152","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24394-z","volume":"8","author":"AJ Reber","year":"2018","unstructured":"Reber AJ, Music N, Kim JH, Gansebom S, Chen J, York I (2018) Extensive T cell cross-reactivity between diverse seasonal influenza strains in the ferret model. Sci Rep 8(1):6112","journal-title":"Sci Rep"},{"issue":"5","key":"4928_CR151","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1586\/erv.13.35","volume":"12","author":"A Reber","year":"2013","unstructured":"Reber A, Katz J (2013) Immunological assessment of influenza vaccines and immune correlates of protection. Expert Rev Vaccines 12(5):519\u2013536","journal-title":"Expert Rev Vaccines"},{"issue":"2","key":"4928_CR154","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.01526-20","volume":"95","author":"ZB Reneer","year":"2020","unstructured":"Reneer ZB, Jamieson PJ, Skarlupka AL, Huang Y, Ross TM (2020) Computationally optimized broadly reactive H2 HA influenza vaccines elicited broadly cross-reactive antibodies and protected mice from viral challenges. J Virol 95(2):10\u20131128","journal-title":"J Virol"},{"issue":"2","key":"4928_CR153","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/mSphere.00052-21","volume":"6","author":"ZB Reneer","year":"2021","unstructured":"Reneer ZB, Skarlupka AL, Jamieson PJ, Ross TM (2021) Broadly reactive H2 hemagglutinin vaccines elicit cross-reactive antibodies in ferrets preimmune to seasonal influenza A viruses. Msphere 6(2):10\u20131128","journal-title":"Msphere"},{"issue":"2","key":"4928_CR155","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1365-2567.2011.03435.x","volume":"133","author":"KA Richards","year":"2011","unstructured":"Richards KA, Chaves FA, Sant AJ (2011) The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity. Immunology 133(2):246\u2013256","journal-title":"Immunology"},{"issue":"101","key":"4928_CR156","first-page":"313","volume":"18","author":"T Rivera-Hernandez","year":"2014","unstructured":"Rivera-Hernandez T, Carnathan DG, Moyle PM, Toth I, West NP, Young PL et al (2014) The contribution of non-human primate models to the development of human vaccines. Discov Med 18(101):313","journal-title":"Discov Med"},{"key":"4928_CR79","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Guilarte L, M\u00e9ndez C, Reyes A, Rios M, Rom\u00e1n F, Moreno-Tapia D et al (2025) Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial. Nat Commun","DOI":"10.1038\/s41467-025-67102-y"},{"issue":"2","key":"4928_CR157","doi-asserted-by":"publisher","first-page":"10","DOI":"10.21315\/mjms2020.27.2.2","volume":"27","author":"S Romeli","year":"2020","unstructured":"Romeli S, Hassan SS, Yap WB (2020) Multi-epitope peptide-based and vaccinia-based universal influenza vaccine candidates subjected to clinical trials. Malays J Med Sci 27(2):10","journal-title":"Malays J Med Sci"},{"issue":"4","key":"4928_CR158","first-page":"281","volume":"10","author":"S Sabaiduc","year":"2025","unstructured":"Sabaiduc S, Kaweski SE, Separovic L, Gao R, Ranadheera C, Bastien N et al (2025) Emergence of seasonal influenza A (H3N2) variants with immune escape potential warrants enhanced molecular and epidemiological surveillance for the 2025\u20132026 season. J Association Med Microbiol Infect Disease Can 10(4):281\u2013298","journal-title":"J Association Med Microbiol Infect Disease Can"},{"issue":"1","key":"4928_CR163","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/imr.12662","volume":"284","author":"AJ Sant","year":"2018","unstructured":"Sant AJ, DiPiazza AT, Nayak JL, Rattan A, Richards KA (2018) CD 4 T cells in protection from influenza virus: Viral antigen specificity and functional potential. Immunol Rev 284(1):91\u2013105","journal-title":"Immunol Rev"},{"key":"4928_CR162","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3389\/fimmu.2018.01453","volume":"9","author":"S Sant","year":"2018","unstructured":"Sant S, Grzelak L, Wang Z, Pizzolla A, Koutsakos M, Crowe J et al (2018) Single-cell approach to influenza-specific CD8\u2009+\u2009T cell receptor repertoires across different age groups, tissues, and following influenza virus infection. Front Immunol 9:1453","journal-title":"Front Immunol"},{"issue":"6","key":"4928_CR164","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.immuni.2014.12.007","volume":"41","author":"JM Schenkel","year":"2014","unstructured":"Schenkel JM, Masopust D (2014) Tissue-resident memory T cells. Immunity 41(6):886\u201397","journal-title":"Immunity"},{"issue":"2","key":"4928_CR165","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3390\/v13020199","volume":"13","author":"A Schmidt","year":"2021","unstructured":"Schmidt A, Lapuente D (2021) T cell immunity against influenza: the long way from animal models towards a real-life universal flu vaccine. Viruses 13(2):199","journal-title":"Viruses"},{"issue":"2","key":"4928_CR166","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/vaccines6020029","volume":"6","author":"S Sebastian","year":"2018","unstructured":"Sebastian S, Lambe T (2018) Clinical advances in viral-vectored influenza vaccines. Vaccines (Basel) 6(2):29","journal-title":"Vaccines (Basel)"},{"issue":"5","key":"4928_CR167","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/irv.12470","volume":"11","author":"SA Sellers","year":"2017","unstructured":"Sellers SA, Hagan RS, Hayden FG, Fischer WA (2017) The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection. Influenza Other Respir Viruses 11(5):372\u2013393","journal-title":"Influenza Other Respir Viruses"},{"issue":"21","key":"4928_CR168","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1093\/bioinformatics\/btw399","volume":"32","author":"Q M Sheikh","year":"2016","unstructured":"Sheikh QM, Gatherer D, Reche PA, Flower DR (2016) Towards the knowledge-based design of universal influenza epitope ensemble vaccines. Bioinformatics 32(21):3233\u20133239","journal-title":"Bioinformatics"},{"issue":"4","key":"4928_CR169","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040663","volume":"8","author":"AC Sherman","year":"2020","unstructured":"Sherman AC, Lai L, Bower M, Natrajan MS, Huerta C, Karmali V et al (2020) The effects of imprinting and repeated seasonal influenza vaccination on adaptive immunity after influenza vaccination. Vaccines 8(4):663","journal-title":"Vaccines"},{"issue":"2","key":"4928_CR170","doi-asserted-by":"publisher","first-page":"e03479","DOI":"10.1128\/mbio.03479-24","volume":"16","author":"J Sidney","year":"2025","unstructured":"Sidney J, Kim AR, de Vries RD, Peters B, Meade PS, Krammer F et al (2025) Targets of influenza human T-cell response are mostly conserved in H5N1. mBio 16(2):e03479\u2013e03424","journal-title":"mBio"},{"issue":"7","key":"4928_CR171","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2031","volume":"2","author":"B Sl\u00fctter","year":"2017","unstructured":"Sl\u00fctter B, Van Braeckel-Budimir N, Abboud G, Varga SM, Salek-Ardakani S, Harty JT (2017) Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Sci Immunol 2(7):eaag2031","journal-title":"Sci Immunol"},{"key":"4928_CR172","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00237","volume":"6","author":"PC Soema","year":"2015","unstructured":"Soema PC, van Riet E, Kersten G, Amorij JP (2015) Development of cross-protective influenza A vaccines based on cellular responses. Front Immunol 6:237","journal-title":"Front Immunol"},{"key":"4928_CR173","doi-asserted-by":"publisher","first-page":"1718805","DOI":"10.3389\/fimmu.2025.1718805","volume":"16","author":"J Sop","year":"2025","unstructured":"Sop J, Beckey TP, Gutierrez L, Zhang L, Gebo KA, Smith KN et al (2025) T cell immunity to seasonal Influenza A and H5N1 viruses in laboratory workers receiving annual seasonal Influenza vaccines. Front Immunol 16:1718805","journal-title":"Front Immunol"},{"issue":"2","key":"4928_CR174","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/v15020331","volume":"15","author":"CK Souza","year":"2023","unstructured":"Souza CK, Kimble JB, Anderson TK, Arendsee ZW, Hufnagel DE, Young KM et al (2023) Swine-to-ferret transmission of antigenically drifted contemporary swine H3N2 influenza A virus is an indicator of zoonotic risk to humans. Viruses 15(2):331","journal-title":"Viruses"},{"issue":"3","key":"4928_CR175","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.immuni.2025.02.004","volume":"58","author":"A Spangler","year":"2025","unstructured":"Spangler A, Shimberg GD, Mantus GE, Malek R, Cominsky LY, Tsybovsky Y et al (2025) Early influenza virus exposure shapes the B cell response to influenza vaccination in individuals 50 years later. Immunity 58(3):728\u2013744","journal-title":"Immunity"},{"key":"4928_CR176","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fimmu.2016.00195","volume":"7","author":"S Sridhar","year":"2016","unstructured":"Sridhar S (2016) Heterosubtypic T-cell immunity to influenza in humans: challenges for universal T-cell influenza vaccines. Front Immunol 7:195","journal-title":"Front Immunol"},{"issue":"10","key":"4928_CR177","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/nm.3350","volume":"19","author":"S Sridhar","year":"2013","unstructured":"Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W et al (2013) Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med 19(10):1305\u20131312","journal-title":"Nat Med"},{"issue":"37\u201339","key":"4928_CR178","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1016\/j.vaccine.2006.05.092","volume":"24","author":"TM Straight","year":"2006","unstructured":"Straight TM, Ottolini MG, Prince GA, Eichelberger MC (2006) Evidence of a cross-protective immune response to influenza A in the cotton rat model. Vaccine 24(37\u201339):6264\u201371","journal-title":"Vaccine"},{"issue":"1","key":"4928_CR179","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54374-z","volume":"15","author":"J Sun","year":"2024","unstructured":"Sun J, Zheng T, Jia M, Wang Y, Yang J, Liu Y et al (2024) Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus. Nat Commun 15(1):10012","journal-title":"Nat Commun"},{"issue":"24","key":"4928_CR180","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.01603-17","volume":"91","author":"TC Sutton","year":"2017","unstructured":"Sutton TC, Lamirande EW, Bock KW, Moore IN, Koudstaal W, Rehman M et al (2017) In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice. J Virol 91(24):10\u20131128","journal-title":"J Virol"},{"issue":"26","key":"4928_CR181","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126408","volume":"42","author":"J Taaffe","year":"2024","unstructured":"Taaffe J, Ostrowsky JT, Mott J, Goldin S, Friede M, Gsell P et al (2024) Advancing influenza vaccines: A review of next-generation candidates and their potential for global health impact. Vaccine 42(26):126408","journal-title":"Vaccine"},{"key":"4928_CR182","doi-asserted-by":"crossref","unstructured":"Tan PT, Heiny AT, Miotto O, Salmon J, Marques ETA Jr, Lemonnier F et al (2010) Conservation and diversity of influenza A H1N1 HLA-restricted T cell epitope candidates for epitope-based vaccines. PLoS One 5(1):e8754","DOI":"10.1371\/journal.pone.0008754"},{"issue":"1","key":"4928_CR183","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/1743-422X-10-244","volume":"10","author":"M Terajima","year":"2013","unstructured":"Terajima M, Babon JAB, Co MDT, Ennis FA (2013) Cross-reactive human B cell and T cell epitopes between influenza A and B viruses. Virol J 10(1):244","journal-title":"Virol J"},{"key":"4928_CR184","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-16143-w","author":"W Tombari","year":"2025","unstructured":"Tombari W, Khamessi O, Othman H, Kallala O, Mahjoub R, Ghedira K et al (2025) A novel mRNA-based multi-epitope vaccine for rabies virus computationally designed via reverse vaccinology and immunoinformatics. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-025-16143-w","journal-title":"Sci Rep"},{"issue":"11","key":"4928_CR185","doi-asserted-by":"publisher","first-page":"5197","DOI":"10.4049\/jimmunol.159.11.5197","volume":"159","author":"DJ Topham","year":"1997","unstructured":"Topham DJ, Tripp RA, Doherty PC (1997) CD8\u2009+\u2009T cells clear influenza virus by perforin or Fas-dependent processes. J Immunol 159(11):5197\u20135200","journal-title":"J Immunol"},{"issue":"1","key":"4928_CR186","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-025-01259-x","volume":"10","author":"MC Trieu","year":"2025","unstructured":"Trieu MC, Bansal A, S\u00e6vik M, Ljostveit S, Jul-Larsen \u00c5, Cox RJ (2025) Effects of repeated influenza vaccination and infection on durable seroprotection in healthcare workers. NPJ Vaccines 10(1):213","journal-title":"NPJ Vaccines"},{"issue":"5","key":"4928_CR188","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/infdis\/jiu186","volume":"210","author":"TK Tsang","year":"2014","unstructured":"Tsang TK, Cauchemez S, Perera RAPM, Freeman G, Fang VJ, Ip DKM et al (2014) Association between antibody titers and protection against influenza virus infection within households. J Infect Dis 210(5):684\u2013692","journal-title":"J Infect Dis"},{"issue":"1","key":"4928_CR187","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02429-7","volume":"20","author":"TK Tsang","year":"2022","unstructured":"Tsang TK, Lam KT, Liu Y, Fang VJ, Mu X, Leung NHL et al (2022) Investigation of CD4 and CD8 T cell-mediated protection against influenza A virus in a cohort study. BMC Med 20(1):230","journal-title":"BMC Med"},{"key":"4928_CR189","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02429-7","author":"TK Tsang","year":"2022","unstructured":"Tsang TK, Lam KT, Liu Y, Fang VJ, Mu X, Leung NHL et al (2022) Investigation of CD4 and CD8 t cell-mediated protection against influenza A virus in a cohort study. BMC Med. https:\/\/doi.org\/10.1186\/s12916-022-02429-7","journal-title":"BMC Med"},{"issue":"4","key":"4928_CR190","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.4049\/jimmunol.1600939","volume":"199","author":"CM Tully","year":"2017","unstructured":"Tully CM, Chinnakannan S, Mullarkey CE, Ulaszewska M, Ferrara F, Temperton N et al (2017) Novel bivalent viral-vectored vaccines induce potent humoral and cellular immune responses conferring protection against stringent influenza A virus challenge. J Immunol 199(4):1333\u20131341","journal-title":"J Immunol"},{"key":"4928_CR192","doi-asserted-by":"crossref","unstructured":"Tumpey TM, Maines TR, Van Hoeven N, Glaser L, Sol\u00f3rzano A, Pappas C et al (1979) A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007;315(5812):655\u20139","DOI":"10.1126\/science.1136212"},{"issue":"11","key":"4928_CR191","doi-asserted-by":"publisher","first-page":"5141","DOI":"10.1128\/JVI.75.11.5141-5150.2001","volume":"75","author":"TM Tumpey","year":"2001","unstructured":"Tumpey TM, Renshaw M, Clements JD, Katz JM (2001) Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection. J Virol 75(11):5141\u20135150","journal-title":"J Virol"},{"issue":"1","key":"4928_CR193","doi-asserted-by":"publisher","DOI":"10.1038\/srep35033","volume":"6","author":"IEM Uddb\u00e4ck","year":"2016","unstructured":"Uddb\u00e4ck IEM, Steffensen MA, Pedersen SR, Nazerai L, Thomsen AR, Christensen JP (2016) PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A. Sci Rep 6(1):35033","journal-title":"Sci Rep"},{"issue":"9","key":"4928_CR194","doi-asserted-by":"publisher","first-page":"611","DOI":"10.4049\/immunohorizons.2300050","volume":"7","author":"SS Ugale","year":"2023","unstructured":"Ugale SS, Holmes TH, Maysel-Auslender S, Boyd SD, Dekker CL, Davis MM et al (2023) Acute respiratory illness is associated with memory T cell differentiation and other immune cell changes in an age-associated manner. Immunohorizons 7(9):611\u2013618","journal-title":"Immunohorizons"},{"key":"4928_CR195","doi-asserted-by":"crossref","unstructured":"Valkenburg SA, Josephs TM, Clemens EB, Grant EJ, Nguyen THO, Wang GC et al (2016) Molecular basis for universal HLA-A* 0201\u2013restricted CD8\u2009+\u2009T-cell immunity against influenza viruses. Proceedings of the National Academy of Sciences. ;113(16):4440\u20135","DOI":"10.1073\/pnas.1603106113"},{"issue":"1","key":"4928_CR159","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13346-4","volume":"10","author":"CE Van de Sandt","year":"2019","unstructured":"Van de Sandt CE, Clemens EB, Grant EJ, Rowntree LC, Sant S, Halim H et al (2019) Challenging immunodominance of influenza-specific CD8\u2009+\u2009T cell responses restricted by the risk-associated HLA-A* 68: 01 allomorph. Nat Commun 10(1):5579","journal-title":"Nat Commun"},{"issue":"2","key":"4928_CR160","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1128\/JVI.02439-15","volume":"90","author":"CE Van de Sandt","year":"2016","unstructured":"Van de Sandt CE, Kreijtz JHCM, Geelhoed-Mieras MM, Nieuwkoop NJ, Spronken MI, van de Vijver DAMC et al (2016) Differential recognition of influenza a viruses by M158\u201366 epitope-specific CD8\u2009+\u2009T cells is determined by extraepitopic amino acid residues. J Virol 90(2):1009\u20131022","journal-title":"J Virol"},{"issue":"19","key":"4928_CR161","doi-asserted-by":"crossref","first-page":"E2417","DOI":"10.1073\/pnas.1503245112","volume":"112","author":"CE van de Sandt","year":"2015","unstructured":"van de Sandt CE, Rimmelzwaan GF (2015) Immunodominant responses to the influenza virus M158\u201366 epitope: stealth or protection? Proc Natl Acad Sci U S A 112(19):E2417\u2013E2417","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"4928_CR198","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01278-5","volume":"3","author":"K van de Ven","year":"2020","unstructured":"van de Ven K, de Heij F, van Dijken H, Ferreira JA, de Jonge J (2020) Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets. Commun Biol 3(1):564","journal-title":"Commun Biol"},{"issue":"50","key":"4928_CR200","doi-asserted-by":"publisher","first-page":"eadc9937","DOI":"10.1126\/sciadv.adc9937","volume":"8","author":"K van de Ven","year":"2022","unstructured":"van de Ven K, Lanfermeijer J, van Dijken H, Muramatsu H, Vilas Boas de Melo C, Lenz S et al (2022) A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets. Sci Adv 8(50):eadc9937","journal-title":"Sci Adv"},{"key":"4928_CR199","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adc9937","author":"K van de Ven","year":"2022","unstructured":"van de Ven K, Lanfermeijer J, van Dijken H, Muramatsu H, Vilas Boas de Melo C, Lenz S et al (2022) A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets. Sci Adv. https:\/\/doi.org\/10.1126\/sciadv.adc9937","journal-title":"Sci Adv"},{"issue":"2","key":"4928_CR204","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037978","volume":"13","author":"S van de Wall","year":"2021","unstructured":"van de Wall S, Badovinac VP, Harty JT (2021) Influenza-specific lung-resident memory CD8\u2009+\u2009T cells. Cold Spring Harb Perspect Biol 13(2):a037978","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"4928_CR196","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41541-024-00989-8","volume":"9","author":"E Vatzia","year":"2024","unstructured":"Vatzia E, Paudyal B, Dema B, Carr BV, Sedaghat-Rostami E, Gubbins S et al (2024) Aerosol immunization with influenza matrix, nucleoprotein, or both prevents lung disease in pig. NPJ Vaccines 9(1):188","journal-title":"NPJ Vaccines"},{"issue":"11","key":"4928_CR197","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1080\/14760584.2017.1379396","volume":"16","author":"SV Vemula","year":"2017","unstructured":"Vemula SV, Sayedahmed EE, Sambhara S, Mittal SK (2017) Vaccine approaches conferring cross-protection against influenza viruses. Expert Rev Vaccines 16(11):1141\u20131154","journal-title":"Expert Rev Vaccines"},{"key":"4928_CR201","doi-asserted-by":"publisher","first-page":"1376395","DOI":"10.3389\/fimmu.2024.1376395","volume":"15","author":"A Vieira Ant\u00e3o","year":"2024","unstructured":"Vieira Ant\u00e3o A, Oltmanns F, Schmidt A, Viherlehto V, Irrgang P, Rameix-Welti MA et al (2024) Filling two needs with one deed: a combinatory mucosal vaccine against influenza A virus and respiratory syncytial virus. Front Immunol 15:1376395","journal-title":"Front Immunol"},{"issue":"7","key":"4928_CR202","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12070703","volume":"12","author":"N Vilaboa","year":"2024","unstructured":"Vilaboa N, Bloom DC, Canty W, Voellmy R (2024) A broad influenza vaccine based on a heat-activated, tissue-restricted replication-competent herpesvirus. Vaccines (Basel) 12(7):703","journal-title":"Vaccines (Basel)"},{"issue":"15","key":"4928_CR203","doi-asserted-by":"publisher","first-page":"6800","DOI":"10.1128\/JVI.74.15.6800-6807.2000","volume":"74","author":"JTM Voeten","year":"2000","unstructured":"Voeten JTM, Bestebroer TM, Nieuwkoop NJ, Fouchier RAM, Osterhaus A, Rimmelzwaan GF (2000) Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes. J Virol 74(15):6800\u20136807","journal-title":"J Virol"},{"issue":"17","key":"4928_CR205","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.01006-18","volume":"92","author":"L Walz","year":"2018","unstructured":"Walz L, Kays SK, Zimmer G, von Messling V (2018) Neuraminidase-inhibiting antibody titers correlate with protection from heterologous influenza virus strains of the same neuraminidase subtype. J Virol 92(17):10\u20131128","journal-title":"J Virol"},{"issue":"8","key":"4928_CR208","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3390\/vaccines13080863","volume":"13","author":"L Wang","year":"2025","unstructured":"Wang L, Xie Q, Yu P, Zhang J, He C, Huang W et al (2025) Research progress of universal influenza vaccine. Vaccines (Basel) 13(8):863","journal-title":"Vaccines (Basel)"},{"key":"4928_CR210","doi-asserted-by":"crossref","unstructured":"Wang, S., Kong, L., Wang, L., Zhuang, Y., Guo, C., Zhang, Y.,\u2026 Jiang, C. (2025). Viral expression of NE\/PPE enhances anti-colorectal cancer efficacy of oncolytic adenovirus by promoting TAM M1 polarization to reverse insufficient effector memory\/effector CD8\u2009+\u2009T cell infiltration. Journal of Experimental & Clinical Cancer Research, 44(1),97. doi: 10.1186\/s13046-025-03358-y","DOI":"10.1186\/s13046-025-03358-y"},{"key":"4928_CR207","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2025.102787","author":"T Wang","year":"2026","unstructured":"Wang T, Han R, Hao Z, Cheng X, Li J, Zhai C et al (2026) Improved cross-protection and immunity against influenza A virus in mice using a novel mRNA vaccine with optimized design of RNA sequence. Mol Ther Nucleic Acids. https:\/\/doi.org\/10.1016\/j.omtn.2025.102787","journal-title":"Mol Ther Nucleic Acids"},{"issue":"6","key":"4928_CR206","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1128\/CVI.00091-15","volume":"22","author":"W Wang","year":"2015","unstructured":"Wang W, Li R, Deng Y, Lu N, Chen H, Meng X et al (2015) Protective efficacy of the conserved NP, PB1, and M1 proteins as immunogens in DNA-and vaccinia virus-based universal influenza A virus vaccines in mice. Clin Vaccine Immunol 22(6):618\u2013630","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"4928_CR209","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12929-023-00977-5","volume":"30","author":"YS Wang","year":"2023","unstructured":"Wang YS, Kumari M, Chen GH, Hong MH, Yuan JPY, Tsai JL et al (2023) mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications. J Biomed Sci 30(1):84","journal-title":"J Biomed Sci"},{"issue":"3","key":"4928_CR211","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1080\/21645515.2017.1413518","volume":"14","author":"BJ Ward","year":"2018","unstructured":"Ward BJ, Pillet S, Charland N, Trepanier S, Couillard J, Landry N (2018) The establishment of surrogates and correlates of protection: useful tools for the licensure of effective influenza vaccines? Hum Vaccin Immunother 14(3):647\u2013656","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"4928_CR212","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1128\/mr.56.1.152-179.1992","volume":"56","author":"RG Webster","year":"1992","unstructured":"Webster RG, Bean WJ, Gorman OT, Chambers TM, Kawaoka Y (1992) Evolution and ecology of influenza A viruses. Microbiol Rev 56(1):152\u2013179","journal-title":"Microbiol Rev"},{"key":"4928_CR214","doi-asserted-by":"crossref","unstructured":"Weinfurter JT, Brunner K, Capuano SV III, Li C, Broman KW, Kawaoka Y et al (2011) Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates. PLoS Pathog 7(11):e1002381","DOI":"10.1371\/journal.ppat.1002381"},{"issue":"3","key":"4928_CR213","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/vaccines13030331","volume":"13","author":"Y Wei","year":"2025","unstructured":"Wei Y, Sun K, Han X, Sun Y, Zhang J, Wang Y et al (2025) Application of humanized MHC transgenic mice in the screening of HLA\u2013restricted T cell epitopes for influenza vaccines. Vaccines (Basel) 13(3):331","journal-title":"Vaccines (Basel)"},{"issue":"2","key":"4928_CR215","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/nm.2612","volume":"18","author":"TM Wilkinson","year":"2012","unstructured":"Wilkinson TM, Li CKF, Chui CSC, Huang AKY, Perkins M, Liebner JC et al (2012) Preexisting influenza-specific CD4\u2009+\u2009T cells correlate with disease protection against influenza challenge in humans. Nat Med 18(2):274\u2013280","journal-title":"Nat Med"},{"issue":"29","key":"4928_CR216","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1016\/j.vaccine.2012.02.076","volume":"30","author":"S Wilks","year":"2012","unstructured":"Wilks S, de Graaf M, Smith DJ, Burke DF (2012) A review of influenza haemagglutinin receptor binding as it relates to pandemic properties. Vaccine 30(29):4369\u20134376","journal-title":"Vaccine"},{"key":"4928_CR218","doi-asserted-by":"crossref","unstructured":"Wu C, Zanker D, Valkenburg S, Tan B, Kedzierska K, Zou QM et al (2011) Systematic identification of immunodominant CD8\u2009+\u2009T-cell responses to influenza A virus in HLA-A2 individuals. Proceedings of the National Academy of Sciences. ;108(22):9178\u201383","DOI":"10.1073\/pnas.1105624108"},{"issue":"6","key":"4928_CR217","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.chom.2019.04.013","volume":"25","author":"NC Wu","year":"2019","unstructured":"Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU et al (2019) Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility. Cell Host Microbe 25(6):836\u2013844","journal-title":"Cell Host Microbe"},{"issue":"2","key":"4928_CR219","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2256422","volume":"12","author":"F Xiong","year":"2023","unstructured":"Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y et al (2023) An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect 12(2):2256422","journal-title":"Emerg Microbes Infect"},{"issue":"2","key":"4928_CR221","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2220630","volume":"19","author":"K Xu","year":"2023","unstructured":"Xu K, Gao B, Li J, Xiang Y, Cao L, Zhao M (2023) Clinical features, diagnosis, and management of COVID-19 vaccine-associated Vogt-Koyanagi-Harada disease. Hum Vaccin Immunother 19(2):2220630. https:\/\/doi.org\/10.1080\/21645515.2023.2220630","journal-title":"Hum Vaccin Immunother"},{"issue":"4","key":"4928_CR220","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1128\/JVI.02162-09","volume":"84","author":"R Xu","year":"2010","unstructured":"Xu R, McBride R, Paulson JC, Basler CF, Wilson IA (2010) Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic. J Virol 84(4):1715\u20131721","journal-title":"J Virol"},{"issue":"1","key":"4928_CR223","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13567-025-01462-7","volume":"56","author":"F Yang","year":"2025","unstructured":"Yang F, Cheng L, Liu F, Yao H, Wu N, Xu L et al (2025) Genetic and molecular characterization of a novel reassortant H3N2 influenza virus from a sick pig in Eastern China in 2019. Vet Res 56(1):38","journal-title":"Vet Res"},{"key":"4928_CR224","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114171","author":"YR Yang","year":"2024","unstructured":"Yang YR, Han J, Perrett HR, Richey ST, Rodriguez AJ, Jackson AM et al (2024) Immune memory shapes human polyclonal antibody responses to H2N2 vaccination. Cell Rep. https:\/\/doi.org\/10.1016\/j.celrep.2024.114171","journal-title":"Cell Rep"},{"key":"4928_CR225","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2026.1671035","author":"Z Yang","year":"2026","unstructured":"Yang Z, Li Y, Chen L, Jia S (2026) Designing a broad-spectrum multi-epitope vaccine against influenza A and Mycoplasma pneumoniae: an immunoinformatics approach. Front Public Health. https:\/\/doi.org\/10.3389\/fpubh.2026.1671035","journal-title":"Front Public Health"},{"issue":"2","key":"4928_CR222","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ymthe.2024.01.007","volume":"32","author":"J Yan","year":"2024","unstructured":"Yan J, Bangalore CR, Nikouyan N, Appelberg S, Silva DN, Yao H et al (2024) Distinct roles of vaccine-induced SARS-CoV-2-specific neutralizing antibodies and T cells in protection and disease. Mol Ther 32(2):540\u201355. https:\/\/doi.org\/10.1016\/j.ymthe.2024.01.007","journal-title":"Mol Ther"},{"issue":"4","key":"4928_CR226","doi-asserted-by":"publisher","DOI":"10.3390\/biology15040357","volume":"15","author":"L Yuan","year":"2026","unstructured":"Yuan L, Ouyang Z, Zhao Y, Bi R, Wu Y, Li X et al (2026) Clinical serum-anchored computational design pipeline for a broad-spectrum Influenza multi-epitope mRNA vaccine. Biology 15(4):357. https:\/\/doi.org\/10.3390\/biology15040357","journal-title":"Biology"},{"issue":"4","key":"4928_CR227","doi-asserted-by":"publisher","DOI":"10.3390\/biology15040357","volume":"15","author":"L Yuan","year":"2026","unstructured":"Yuan L, Ouyang Z, Zhao Y, Bi R, Wu Y, Li X et al (2026) Clinical serum-anchored computational design pipeline for a broad-spectrum Influenza multi-epitope mRNA vaccine. Biology (Basel) 15(4):357. https:\/\/doi.org\/10.3390\/biology15040357","journal-title":"Biology (Basel)"},{"issue":"10","key":"4928_CR228","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.85832","volume":"1","author":"KD Zens","year":"2016","unstructured":"Zens KD, Chen JK, Farber DL (2016) Vaccine-generated lung tissue\u2013resident memory T cells provide heterosubtypic protection to influenza infection. JCI Insight 1(10):e85832","journal-title":"JCI Insight"},{"issue":"2","key":"4928_CR231","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2023.2263229","volume":"19","author":"HQ Zhang","year":"2023","unstructured":"Zhang HQ, Cao BZ, Cao QT, Hun M, Cao L, Zhao MY (2023) An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination. Hum Vaccin Immunother 19(2):2263229. https:\/\/doi.org\/10.1080\/21645515.2023.2263229","journal-title":"Hum Vaccin Immunother"},{"issue":"12","key":"4928_CR230","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.00507-21","volume":"95","author":"H Zhang","year":"2021","unstructured":"Zhang H, Zheng H, Guo P, Hu L, Wang Z, Wang J et al (2021) Broadly protective CD8\u2009+\u2009T cell immunity to highly conserved epitopes elicited by heat shock protein gp96-adjuvanted influenza monovalent split vaccine. J Virol 95(12):10\u20131128","journal-title":"J Virol"},{"key":"4928_CR229","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943331","volume":"13","author":"M Zhang","year":"2022","unstructured":"Zhang M, Li N, He Y, Shi T, Jie Z (2022) Pulmonary resident memory T cells in respiratory virus infection and their inspiration on therapeutic strategies. Front Immunol 13:943331","journal-title":"Front Immunol"},{"issue":"10","key":"4928_CR234","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.4049\/jimmunol.2200577","volume":"209","author":"MZM Zheng","year":"2022","unstructured":"Zheng MZM, Fritzlar S, Wang Z, Tan TK, Kedzierska K, Townsend A et al (2022) Cutting edge: high-dose live attenuated influenza vaccines elicit pulmonary tissue-resident memory CD8\u2009+\u2009T cells in the face of pre-existing humoral immunity. J Immunol 209(10):1832\u20131836","journal-title":"J Immunol"},{"issue":"36","key":"4928_CR233","doi-asserted-by":"publisher","first-page":"eadg3469","DOI":"10.1126\/sciadv.adg3469","volume":"9","author":"MZM Zheng","year":"2023","unstructured":"Zheng MZM, Tan TK, Villalon-Letelier F, Lau H, Deng YM, Fritzlar S et al (2023) Single-cycle influenza virus vaccine generates lung CD8\u2009+\u2009Trm that cross-react against viral variants and subvert virus escape mutants. Sci Adv 9(36):eadg3469","journal-title":"Sci Adv"},{"issue":"3","key":"4928_CR232","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41385-021-00461-z","volume":"15","author":"MZM Zheng","year":"2022","unstructured":"Zheng MZM, Wakim LM (2022) Tissue resident memory T cells in the respiratory tract. Mucosal Immunol 15(3):379\u2013388","journal-title":"Mucosal Immunol"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-04928-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-04928-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-04928-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:02:33Z","timestamp":1785574953000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-026-04928-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":234,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4928"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-04928-0","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"23 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"404"}}