{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:17:01Z","timestamp":1787912221057,"version":"build-2784847793"},"reference-count":149,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00203-026-05000-7","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:08:33Z","timestamp":1780996113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IgY technology (egg yolk antibodies) in respiratory medicine: applications and future prospects"],"prefix":"10.1007","volume":"208","author":[{"given":"Preethi","family":"Sivasubramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthikeyan","family":"Alagarsamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Mrudubhashini","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangavelu Umashankar","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Antonysamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"issue":"1","key":"5000_CR1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/21645515.2018.1514224","volume":"15","author":"AT Abbas","year":"2019","unstructured":"Abbas AT, El-Kafrawy SA, Sohrab SS, Azhar EIA (2019) IgY antibodies for the immunoprophylaxis and therapy of respiratory infections. Hum vaccines immunotherapeutics 15(1):264\u2013275. https:\/\/doi.org\/10.1080\/21645515.2018.1514224","journal-title":"Hum vaccines immunotherapeutics"},{"issue":"4","key":"5000_CR2","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/vaccines8040634","volume":"8","author":"AT Abbas","year":"2020","unstructured":"Abbas AT, El-Kafrawy SA, Sohrab SS, Tabll AA, Hassan AM, Iwata-Yoshikawa N, Azhar EI (2020) Anti-S1 MERS-COV IgY specific antibodies decreases lung inflammation and viral antigen positive cells in the human transgenic mouse model. Vaccines 8(4):634. https:\/\/doi.org\/10.3390\/vaccines8040634","journal-title":"Vaccines"},{"key":"5000_CR3","unstructured":"Abdelhadi ATA, Azhar EIA, Elkafrawy SAA, Sohrab SS (2022) U.S. Patent No. 11,307,202. Washington, DC: U.S. Patent and Trademark Office. https:\/\/patentimages.storage.googleapis.com\/6b\/e9\/80\/7f9708b5006297\/US11307202.pdf"},{"key":"5000_CR4","doi-asserted-by":"publisher","first-page":"103568","DOI":"10.1016\/j.cis.2025.103568","volume":"343","author":"R Abedi-Firoozjah","year":"2025","unstructured":"Abedi-Firoozjah R, Tavassoli M, Zehi ZB, Bahramian B, Doroud N, Sadeghi E, Zhang F, Jafari SM (2025) Seeing the invisible threats: Detecting egg white allergens using bio\/nano-sensors; a comprehensive review. Adv Colloid Interface Sci 343:103568. https:\/\/doi.org\/10.1016\/j.cis.2025.103568","journal-title":"Adv Colloid Interface Sci"},{"key":"5000_CR5","doi-asserted-by":"publisher","first-page":"881604","DOI":"10.3389\/fimmu.2022.881604","volume":"13","author":"A Agurto-Arteaga","year":"2022","unstructured":"Agurto-Arteaga A, Poma-Acevedo A, Rios-Matos D, Choque-Guevara R, Montesinos-Mill\u00e1n R, Montalv\u00e1n \u00c1, COVID-19 Working Group in Per\u00fa (2022) Preclinical assessment of IgY antibodies against recombinant SARS-CoV-2 RBD protein for prophylaxis and post-infection treatment of COVID-19. Front Immunol 13:881604. https:\/\/doi.org\/10.3389\/fimmu.2022.881604","journal-title":"Front Immunol"},{"key":"5000_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.molimm.2021.06.002","volume":"136","author":"TS Ahmadi","year":"2021","unstructured":"Ahmadi TS, Gargari M, S. L., Talei D (2021) Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode. Mol Immunol 136:118\u2013127. https:\/\/doi.org\/10.1016\/j.molimm.2021.06.002","journal-title":"Mol Immunol"},{"issue":"1","key":"5000_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41598-023-50859-x","volume":"14","author":"TS Ahmadi","year":"2024","unstructured":"Ahmadi TS, Behrouz B, Mousavi Gargari SL (2024) Polyclonal anti-whole cell IgY passive immunotherapy shields against P. aeruginosa-induced acute pneumonia and burn wound infections in murine models. Sci Rep 14(1):405. https:\/\/doi.org\/10.1038\/s41598-023-50859-x","journal-title":"Sci Rep"},{"issue":"1","key":"5000_CR9","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s41598-023-50501-w","volume":"14","author":"KM Al-Qaoud","year":"2024","unstructured":"Al-Qaoud KM, Obeidat YM, Al-Omari T, Okour M, Al-Omari MM, Ahmad MI, Alshadfan R, Rawashdeh AM (2024) The development of an electrochemical immunosensor utilizing chicken IgY anti-spike antibody for the detection of SARS-CoV-2. Sci Rep 14(1):748. https:\/\/doi.org\/10.1038\/s41598-023-50501-w","journal-title":"Sci Rep"},{"key":"5000_CR8","doi-asserted-by":"publisher","unstructured":"Ali A, Irshad U, Azmat U, Akbar K (2025) ACE2 expression patterns across mammals and key findings for SARS-CoV-2 model development for human and animal research. Pak Vet J 45(1). https:\/\/doi.org\/10.29261\/pakvetj\/2025.142","DOI":"10.29261\/pakvetj\/2025.142"},{"issue":"5","key":"5000_CR10","doi-asserted-by":"publisher","first-page":"e0252399","DOI":"10.1371\/journal.pone.0252399","volume":"16","author":"C Artman","year":"2021","unstructured":"Artman C, Brumfield KD, Khanna S, Goepp J (2021) Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication. PLoS ONE 16(5):e0252399. https:\/\/doi.org\/10.1371\/journal.pone.0252399","journal-title":"PLoS ONE"},{"issue":"7","key":"5000_CR11","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.3390\/v14071510","volume":"14","author":"EJ Aston","year":"2022","unstructured":"Aston EJ, Wallach MG, Narayanan A, Ega\u00f1a-Labrin S, Gallardo RA (2022) Hyperimmunized chickens produce neutralizing antibodies against SARS-CoV-2. Viruses 14(7):1510. https:\/\/doi.org\/10.3390\/v14071510","journal-title":"Viruses"},{"key":"5000_CR12","unstructured":"Azhar EI, El-Kafrawy SA, Abbas AT, Tabil AA (2022) U.S. Patent No. 11,319,382. Washington, DC: U.S. Patent and Trademark Office. https:\/\/patentimages.storage.googleapis.com\/35\/7e\/35\/0891bf9b1037cf\/US11319382.pdf"},{"issue":"3","key":"5000_CR13","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1111\/jam.15340","volume":"132","author":"L Bao","year":"2022","unstructured":"Bao L, Zhang C, Lyu J, Yi P, Shen X, Tang B, Zhao H, Ren B, Kuang Y, Zhou L, Li Y (2022) Egg yolk immunoglobulin (IgY) targeting SARS-CoV-2 S1 as potential virus entry blocker. J Appl Microbiol 132(3):2421\u20132430. https:\/\/doi.org\/10.1111\/jam.15340","journal-title":"J Appl Microbiol"},{"key":"5000_CR14","doi-asserted-by":"publisher","first-page":"1723343","DOI":"10.3389\/fimmu.2025.1723343","volume":"16","author":"AA Basabrain","year":"2025","unstructured":"Basabrain AA, Alandijany TA (2025) Unique antibodies across the animal kingdom (birds, camelids, and sharks): therapeutic potential against human respiratory viral infections. Front Immunol 16:1723343. https:\/\/doi.org\/10.3389\/fimmu.2025.1723343","journal-title":"Front Immunol"},{"key":"5000_CR15","unstructured":"Beachey W (2022) Respiratory care anatomy and physiology E-book: foundations for clinical practice. Elsevier Health Sciences. https:\/\/refhub.elsevier.com\/S0048-9697(20)37827-X\/rf0050"},{"issue":"Supplement2","key":"5000_CR16","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1093\/jpids\/piac052","volume":"11","author":"AC Blanchard","year":"2022","unstructured":"Blanchard AC, Waters VJ (2022) Opportunistic pathogens in cystic fibrosis: epidemiology and pathogenesis of lung infection. J Pediatr Infect Dis Soc 11(Supplement2):S3\u2013S12. https:\/\/doi.org\/10.1093\/jpids\/piac052","journal-title":"J Pediatr Infect Dis Soc"},{"issue":"5","key":"5000_CR17","doi-asserted-by":"publisher","first-page":"e12353","DOI":"10.1002\/clt2.12353","volume":"14","author":"J Bousquet","year":"2024","unstructured":"Bousquet J, Gherasim A, de Blay F, Mathieu-Dupas E, Batot G, Laune D, Sousa\u2010Pinto B, Zuberbier T, Pham\u2010Thi N (2024) MASK\u2010cat study group, Hofmann B. Proof\u2010of\u2010concept study of anti\u2010Fel d 1 IgY antibodies in cat food using the MASK\u2010air\u00ae app. Clin translational allergy 14(5):e12353. https:\/\/doi.org\/10.1002\/clt2.12353","journal-title":"Clin translational allergy"},{"issue":"6","key":"5000_CR18","doi-asserted-by":"publisher","first-page":"e360","DOI":"10.1016\/S2589-7500(21)00077-7","volume":"3","author":"AB Brueggemann","year":"2021","unstructured":"Brueggemann AB, Van Rensburg J, Shaw MJ, McCarthy D, Jolley ND, Maiden KA, Van Der Linden MCJ, Amin-Chowdhury MPG, Bennett Z, Borrow DE, Brandileone R, Broughton M-CC, Campbell K, Cao R, Casanova B, Choi C, Chu EH, Clark YW, Claus SA, Zhou H, F (2021) Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: A prospective analysis of surveillance data. Lancet Digit Health 3(6):e360\u2013e370. https:\/\/doi.org\/10.1016\/S2589-7500(21)00077-7","journal-title":"Lancet Digit Health"},{"key":"5000_CR19","doi-asserted-by":"publisher","first-page":"113798","DOI":"10.1016\/j.jim.2024.113798","volume":"536","author":"GN Brujeni","year":"2025","unstructured":"Brujeni GN, Houshmand P, Sadafian S, Rezaei R (2025) Natural cross-reactive anti-SARS-CoV-2 antibodies in avian egg yolk. J Immunol Methods 536:113798. https:\/\/doi.org\/10.1016\/j.jim.2024.113798","journal-title":"J Immunol Methods"},{"issue":"10","key":"5000_CR20","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1080\/10826068.2018.1525564","volume":"48","author":"Y Budama-Kilinc","year":"2018","unstructured":"Budama-Kilinc Y, Cakir-Koc R, Ozdemir B, Kaya Z, Badur S (2018) Production and characterization of a conserved M2e peptide-based specific IgY antibody: Evaluation of the diagnostic potential via conjugation with latex nanoparticles. Prep Biochem Biotechnol 48(10):930\u2013939. https:\/\/doi.org\/10.1080\/10826068.2018.1525564","journal-title":"Prep Biochem Biotechnol"},{"key":"5000_CR21","doi-asserted-by":"publisher","first-page":"111226","DOI":"10.1016\/j.buildenv.2024.111226","volume":"251","author":"J Cai","year":"2024","unstructured":"Cai J, Yang M, Zhang N, Chen Y, Wei J, Wang J, Liu W (2024) Effects of residential damp indicators on asthma, rhinitis, and eczema among children: a systematic review and meta-analysis of the literature in the past 33 years. Build Environ 251:111226. https:\/\/doi.org\/10.1016\/j.buildenv.2024.111226","journal-title":"Build Environ"},{"issue":"13","key":"5000_CR22","doi-asserted-by":"publisher","first-page":"6380","DOI":"10.3390\/ijms26136380","volume":"26","author":"R Capot\u0103","year":"2025","unstructured":"Capot\u0103 R, Ciau\u0219u-Sliwa D, Bost\u0103naru-Iliescu AC, N\u0103stas\u0103 V, Mare\u0219 M (2025) Latest findings in immunoglobulin Y technologies and applications. Int J Mol Sci 26(13):6380. https:\/\/doi.org\/10.3390\/ijms26136380","journal-title":"Int J Mol Sci"},{"issue":"3","key":"5000_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3109\/03009739909178961","volume":"104","author":"D Carlander","year":"1999","unstructured":"Carlander D, St\u00e5lberg J, Larsson A (1999) Chicken antibodies: a clinical chemistry perspective. Ups J Med Sci 104(3):179\u2013189. https:\/\/doi.org\/10.3109\/03009739909178961","journal-title":"Ups J Med Sci"},{"key":"5000_CR24","doi-asserted-by":"publisher","first-page":"106690","DOI":"10.1016\/j.buildenv.2020.106690","volume":"175","author":"FM Chegini","year":"2020","unstructured":"Chegini FM, Baghani AN, Hassanvand MS, Sorooshian A, Golbaz S, Bakhtiari R, Ashouri A, Joubani MN, Alimohammadi M (2020) Indoor and outdoor airborne bacterial and fungal air quality in kindergartens: seasonal distribution, genera, levels, and factors influencing their concentration. Build Environ 175:106690. https:\/\/doi.org\/10.1016\/j.buildenv.2020.106690","journal-title":"Build Environ"},{"issue":"3","key":"5000_CR25","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/ame2.12180","volume":"4","author":"Q Chen","year":"2021","unstructured":"Chen Q, Shen Y, Zheng J (2021) A review of cystic fibrosis: Basic and clinical aspects. Anim Models Exp Med 4(3):220\u2013232. https:\/\/doi.org\/10.1002\/ame2.12180","journal-title":"Anim Models Experimental Med"},{"key":"5000_CR26","doi-asserted-by":"publisher","unstructured":"Cheng K, Ashby D, Smyth RL (2015) Oral steroids for long-term use in cystic fibrosis. Cochrane Database Syst Reviews 2021(4). https:\/\/doi.org\/10.1002\/14651858.CD000407.pub4","DOI":"10.1002\/14651858.CD000407.pub4"},{"issue":"3","key":"5000_CR89","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3390\/vaccines8030486","volume":"8","author":"JM de la P\u00e9rez","year":"2020","unstructured":"de la P\u00e9rez JM, Baca-Gonz\u00e1lez V, Asensio-Calavia P, Gonz\u00e1lez-Acosta S, Morales-delaNuez A (2020) Can immunization of hens provide oral-based therapeutics against COVID-19? Vaccines 8(3):486. https:\/\/doi.org\/10.3390\/vaccines8030486","journal-title":"Vaccines"},{"issue":"5","key":"5000_CR28","doi-asserted-by":"publisher","first-page":"e97716","DOI":"10.1371\/journal.pone.0097716","volume":"9","author":"T Diraviyam","year":"2014","unstructured":"Diraviyam T, Zhao B, Wang Y, Schade R, Michael A, Zhang X (2014) Effect of chicken egg yolk antibodies (IgY) against diarrhea in domesticated animals: a systematic review and meta-analysis. PLoS ONE 9(5):e97716. https:\/\/doi.org\/10.1371\/journal.pone.0097716","journal-title":"PLoS ONE"},{"issue":"2","key":"5000_CR29","doi-asserted-by":"publisher","first-page":"AB206","DOI":"10.1016\/j.jaci.2009.12.806","volume":"125","author":"E Egea","year":"2010","unstructured":"Egea E, Mendoza DL, Garavito G, Navarro EA, Barrera L, Espejo AJ (2010) Mite allergen specific IgY antibodies as a novel tool for detecting house dust mite allergens in intramural environments. J Allergy Clin Immunol 125(2):AB206. https:\/\/doi.org\/10.1016\/j.jaci.2009.12.806","journal-title":"J Allergy Clin Immunol"},{"key":"5000_CR30","doi-asserted-by":"publisher","first-page":"109280","DOI":"10.1016\/j.intimp.2022.109280","volume":"112","author":"M Eka Saputri","year":"2022","unstructured":"Eka Saputri M, Aisyah Rahmalia Effendi S, Nadila R, Azzam Fajar S, Soejoedono D, Handharyani R, E., Poetri N, O (2022) Immunoglobulin yolk targeting spike 1, receptor binding domain of spike glycoprotein and nucleocapsid of SARS-CoV-2 blocking RBD-ACE2 binding interaction. Int Immunopharmacol 112:109280. https:\/\/doi.org\/10.1016\/j.intimp.2022.109280","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"5000_CR31","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/ph14060511","volume":"14","author":"SA El-Kafrawy","year":"2021","unstructured":"El-Kafrawy SA, Abbas AT, Sohrab SS, Tabll AA, Hassan AM, Iwata-Yoshikawa N, Nagata N, Azhar EI (2021) Immunotherapeutic efficacy of IgY antibodies targeting the full-length spike protein in an animal model of middle east respiratory syndrome coronavirus infection. Pharmaceuticals 14(6):511. https:\/\/doi.org\/10.3390\/ph14060511","journal-title":"Pharmaceuticals"},{"issue":"9","key":"5000_CR32","doi-asserted-by":"publisher","first-page":"e1010782","DOI":"10.1371\/journal.ppat.1010782","volume":"18","author":"SA El-Kafrawy","year":"2022","unstructured":"El-Kafrawy SA, Odle A, Abbas AT, Hassan AM, Abdel-Dayem UA, Qureshi AK, Azhar EI (2022) SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice. PLoS Pathog 18(9):e1010782. https:\/\/doi.org\/10.1371\/journal.ppat.1010782","journal-title":"PLoS Pathog"},{"key":"5000_CR33","doi-asserted-by":"publisher","first-page":"1065353","DOI":"10.3389\/fimmu.2023.1065353","volume":"14","author":"SA El-Kafrawy","year":"2023","unstructured":"El-Kafrawy SA, Abbas AT, Oelkrug C, Tahoon M, Ezzat S, Zumla A, Azhar EI (2023) IgY antibodies: the promising potential to overcome antibiotic resistance. Front Immunol 14:1065353. https:\/\/doi.org\/10.3389\/fimmu.2023.1065353","journal-title":"Front Immunol"},{"issue":"25","key":"5000_CR34","doi-asserted-by":"publisher","first-page":"126133","DOI":"10.1016\/j.vaccine.2024.07.034","volume":"42","author":"M Eriksson","year":"2024","unstructured":"Eriksson M, Nyl\u00e9n S, Gr\u00f6nvik K-O (2024) Passive immunization of mice with IgY anti-H5N1 protects against experimental influenza virus infection and allows development of protective immunity. Vaccine 42(25):126133. https:\/\/doi.org\/10.1016\/j.vaccine.2024.07.034","journal-title":"Vaccine"},{"issue":"3","key":"5000_CR35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5455\/JMID.2024.v14.i3.2","volume":"14","author":"Z Esmaeili","year":"2024","unstructured":"Esmaeili Z, Shahsavar SK, Keikha M, Ghazvini K (2024) Chicken immunoglobulin (IgY) as an alternative treatment for bacterial infections, emphasizing advantages, disadvantages and mechanisms. J Microbiol Infect Dis 14(3):95\u201395. https:\/\/doi.org\/10.5455\/JMID.2024.v14.i3.2","journal-title":"J Microbiol Infect Dis"},{"issue":"2","key":"5000_CR36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/abt\/tbaf007","volume":"8","author":"Z Esmaeili","year":"2025","unstructured":"Esmaeili Z, Kamal Shahsavar S, Ghazvini K (2025) A systematic review of the avian antibody (IgY) therapeutic effects on human bacterial infections over the decade. Antib Ther 8(2):111\u2013123. https:\/\/doi.org\/10.1093\/abt\/tbaf007","journal-title":"Antib Ther"},{"key":"5000_CR37","doi-asserted-by":"publisher","first-page":"117594","DOI":"10.1016\/j.lfs.2020.117594","volume":"252","author":"S Fatima","year":"2020","unstructured":"Fatima S, Kumari A, Das G, Dwivedi VP (2020) Tuberculosis vaccine: a journey from BCG to present. Life Sci 252:117594. https:\/\/doi.org\/10.1016\/j.lfs.2020.117594","journal-title":"Life Sci"},{"issue":"04","key":"5000_CR38","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1055\/s-0040-1702193","volume":"41","author":"C Feldman","year":"2020","unstructured":"Feldman C, Anderson R (2020) The role of streptococcus pneumoniae in community-acquired pneumonia. Semin Respir Crit Care Med 41(04):455\u2013469. https:\/\/doi.org\/10.1055\/s-0040-1702193","journal-title":"Semin Respir Crit Care Med"},{"key":"5000_CR39","doi-asserted-by":"publisher","first-page":"115062","DOI":"10.1016\/j.jviromet.2024.115062","volume":"331","author":"A Fibriani","year":"2025","unstructured":"Fibriani A, Naisanu K, Yamahoki N, Kinanti DR (2025) Development of polyclonal chicken egg yolk immunoglobulin Y (IgY) antibodies targeting SARS-CoV-2 multi-epitope antigen. J Virol Methods 331:115062. https:\/\/doi.org\/10.1016\/j.jviromet.2024.115062","journal-title":"J Virol Methods"},{"issue":"8","key":"5000_CR40","doi-asserted-by":"publisher","first-page":"898","DOI":"10.3390\/pathogens11080898","volume":"11","author":"C Forero","year":"2022","unstructured":"Forero C, Ritter JM, Seixas JN, Coleman-McCray JD, Brake M, Condrey JA, Tansey C, Welch SR, Genzer SC, Spengler JR (2022) Volume-associated clinical and histopathological effects of intranasal instillation in Syrian Hamsters: considerations for infection and therapeutic studies. Pathogens 11(8):898. https:\/\/doi.org\/10.3390\/pathogens11080898","journal-title":"Pathogens"},{"key":"5000_CR41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.prrv.2024.08.002","volume":"54","author":"L Frigati","year":"2025","unstructured":"Frigati L, Greybe L, Andronikou S, Eber E, Venkatakrishna SS, Goussard P (2025) Respiratory infections in low and middle-income countries. Paediatr Respir Rev 54:43\u201351. https:\/\/doi.org\/10.1016\/j.prrv.2024.08.002","journal-title":"Paediatr Respir Rev"},{"key":"5000_CR42","doi-asserted-by":"publisher","first-page":"899617","DOI":"10.3389\/fimmu.2022.899617","volume":"13","author":"LR Frumkin","year":"2022","unstructured":"Frumkin LR, Lucas M, Scribner CL, Ortega-Heinly N, Rogers J, Yin G, Hallam TJ, Yam A, Bedard K, Begley R, Cohen CA, Badger CV, Abbasi SA, Dye JM, McMillan B, Wallach M, Bricker TL, Joshi A, Boon ACM, Mochly-Rosen D (2022) Egg-derived anti-SARS-CoV-2 immunoglobulin Y (IgY) with broad variant activity as intranasal prophylaxis against COVID-19. Front Immunol 13:899617. https:\/\/doi.org\/10.3389\/fimmu.2022.899617","journal-title":"Front Immunol"},{"issue":"1","key":"5000_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13568-022-01355-4","volume":"12","author":"S Ge","year":"2022","unstructured":"Ge S, Wu R, Zhou T, Liu X, Zhu J, Zhang X (2022) Specific anti-SARS-CoV-2 S1 IgY-scFv is a promising tool for recognition of the virus. AMB Express 12(1):18. https:\/\/doi.org\/10.1186\/s13568-022-01355-4","journal-title":"AMB Express"},{"key":"5000_CR44","doi-asserted-by":"publisher","unstructured":"Ge Y, Yang J, Liu X, An F, Cui Z, Zeng Q (2025) Single-domain antibody fused with chicken IgG Fc-fragment protects goslings against novel goose astrovirus (nGAstV). Pak Vet J 45(1). https:\/\/doi.org\/10.29261\/pakvetj\/2025.120","DOI":"10.29261\/pakvetj\/2025.120"},{"key":"5000_CR45","doi-asserted-by":"publisher","first-page":"1199427","DOI":"10.3389\/fimmu.2023.1199427","volume":"14","author":"R Grzywa","year":"2023","unstructured":"Grzywa R, \u0141upicka-S\u0142owik A, Sie\u0144czyk M, IgYs (2023) On her majesty\u2019s secret service. Front Immunol 14:1199427. https:\/\/doi.org\/10.3389\/fimmu.2023.1199427","journal-title":"Front Immunol"},{"key":"5000_CR46","unstructured":"Hall E (2021) Centers for Disease Control and Prevention. editors. Epidemiology and prevention of vaccine-preventable diseases. US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, USA https:\/\/www.merle-arbeitsmedizin.de\/wp-content\/uploads\/2022\/02\/CDC-Pink-Book-Version-14th-Edition.pdf"},{"issue":"8","key":"5000_CR48","doi-asserted-by":"publisher","first-page":"101136","DOI":"10.1016\/j.apr.2021.101136","volume":"12","author":"A Hassan","year":"2021","unstructured":"Hassan A, Zeeshan M, Bhatti MF (2021) Indoor and outdoor microbiological air quality in naturally and mechanically ventilated university libraries. Atmospheric Pollution Res 12(8):101136. https:\/\/doi.org\/10.1016\/j.apr.2021.101136","journal-title":"Atmospheric Pollution Res"},{"key":"5000_CR49","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/9780470181249.ch5","volume":"185","author":"H Hatta","year":"2008","unstructured":"Hatta H, Kapoor MP, Juneja LR (2008) Bioactive components in egg yolk. Egg bioscience Biotechnol 185:237. https:\/\/doi.org\/10.1002\/9780470181249.ch5","journal-title":"Egg bioscience Biotechnol"},{"key":"5000_CR50","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-5068132\/v1","author":"M Hawkins","year":"2025","unstructured":"Hawkins M, Robley B, Alem F, Narayanan A, Larson P, Hull J, Hajduk I, Wallach M (2025) Economically feasible mass production of egg yolk powder tablets (chicken IgY) for global COVID-19 transmission prevention. Res Sq. https:\/\/doi.org\/10.21203\/rs.3.rs-5068132\/v1","journal-title":"Rev"},{"key":"5000_CR51","unstructured":"Hollsing A (2024) Anti-pseudomonas IgY to prevent infections in cystic fibrosis (PseudIgY) [Internet]"},{"issue":"2","key":"5000_CR52","doi-asserted-by":"publisher","first-page":"e00224","DOI":"10.1128\/CMR.00224-20","volume":"34","author":"EC Holmes","year":"2021","unstructured":"Holmes EC, Hurt AC, Dobbie Z, Clinch B, Oxford JS, Piedra PA (2021) Understanding the impact of resistance to influenza antivirals. Clin Microbiol Rev 34(2):e00224\u2013e00220. https:\/\/doi.org\/10.1128\/CMR.00224-20","journal-title":"Clin Microbiol Rev"},{"issue":"10","key":"5000_CR53","doi-asserted-by":"publisher","first-page":"e1002152","DOI":"10.1371\/journal.pmed.1002152","volume":"13","author":"RMGJ Houben","year":"2016","unstructured":"Houben RMGJ, Dodd PJ (2016) The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med 13(10):e1002152. https:\/\/doi.org\/10.1371\/journal.pmed.1002152","journal-title":"PLoS Med"},{"issue":"7","key":"5000_CR54","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3390\/pharmaceutics17070863","volume":"17","author":"D Inoue","year":"2025","unstructured":"Inoue D, Seto Y, To H (2025) Nasal residence depending on the administered dosage form: impact of formulation type on the in vivo nasal retention time of drugs in rats. Pharmaceutics 17(7):863. https:\/\/doi.org\/10.3390\/pharmaceutics17070863","journal-title":"Pharmaceutics"},{"issue":"3","key":"5000_CR55","doi-asserted-by":"publisher","first-page":"100634","DOI":"10.1016\/j.waojou.2022.100634","volume":"15","author":"O Kalayci","year":"2022","unstructured":"Kalayci O, Miligkos M, Pozo Beltr\u00e1n CF, El-Sayed ZA, G\u00f3mez RM, Hossny E, Le Souef P, Nieto A, Phipatanakul W, Pitrez PM, Xepapadaki P, Jiu-Yao W, Papadopoulos NG (2022) The role of environmental allergen control in the management of asthma. World Allergy Organ J 15(3):100634. https:\/\/doi.org\/10.1016\/j.waojou.2022.100634","journal-title":"World Allergy Organ J"},{"issue":"4","key":"5000_CR56","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3390\/fermentation8040162","volume":"8","author":"P Kesika","year":"2022","unstructured":"Kesika P, Thangaleela S, Sivamaruthi BS, Bharathi M, Chaiyasut C (2022) Fermented foods and their role in respiratory health: a mini-review. Fermentation 8(4):162. https:\/\/doi.org\/10.3390\/fermentation8040162","journal-title":"Fermentation"},{"key":"5000_CR57","unstructured":"Khor NJK (2022) World cities report 2022: Envisaging the future of cities. United Nations Human Settlements Programme (UN-Habitat). https:\/\/unhabitat.org\/sites\/default\/files\/2022\/06\/wcr_2022.pdf"},{"issue":"7","key":"5000_CR58","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.3390\/en15072654","volume":"15","author":"J Kim","year":"2022","unstructured":"Kim J, Hong Y, Seong N, Kim DD (2022) Assessment of ANN algorithms for the concentration prediction of indoor air pollutants in child daycare centers. Energies 15(7):2654. https:\/\/doi.org\/10.3390\/en15072654","journal-title":"Energies"},{"issue":"1","key":"5000_CR59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","volume":"4","author":"F Krammer","year":"2018","unstructured":"Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garc\u00eda-Sastre A (2018) Influenza. Nat Reviews Disease Primers 4(1):3. https:\/\/doi.org\/10.1038\/s41572-018-0002-y","journal-title":"Nat Reviews Disease Primers"},{"issue":"1","key":"5000_CR60","doi-asserted-by":"publisher","first-page":"e00040","DOI":"10.1128\/cmr.00040-22","volume":"36","author":"R Kumari","year":"2023","unstructured":"Kumari R, Sharma SD, Kumar A, Ende Z, Mishina M, Wang Y, Falls Z, Samudrala R, Pohl J, Knight PR, Sambhara S (2023) Antiviral approaches against influenza virus. Clin Microbiol Rev 36(1):e00040\u2013e00022. https:\/\/doi.org\/10.1128\/cmr.00040-22","journal-title":"Clin Microbiol Rev"},{"key":"5000_CR61","doi-asserted-by":"publisher","unstructured":"Kusuma SA, Fadhlillah M, Maisyarah IT, Khairunnisa SA, Yusuf M, Rukayadi Y, Subroto T (2024) Purification of anti-mycobacterium tuberculosis MPT64 immunoglobulin-Y from egg-yolk supernatant using thiophilic adsorption chromatography. Progress Microbes Mol Biology 7(1). https:\/\/doi.org\/10.36877\/pmmb.a0000400","DOI":"10.36877\/pmmb.a0000400"},{"issue":"11","key":"5000_CR62","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/S1473-3099(22)00510-2","volume":"22","author":"HH Kyu","year":"2022","unstructured":"Kyu HH, Vongpradith A, Sirota SB, Novotney A, Troeger CE, Doxey MC, Bender RG, Ledesma JR, Biehl MH, Albertson SB, Frostad JJ, Burkart K, Bennitt FB, Zhao JT, Gardner WM, Hagins H, Bryazka D, Dominguez R-MV, Abate SM, Murray CJL (2022) Age\u2013sex differences in the global burden of lower respiratory infections and risk factors, 1990\u20132019: Results from the Global Burden of Disease Study 2019. Lancet Infect Dis 22(11):1626\u20131647. https:\/\/doi.org\/10.1016\/S1473-3099(22)00510-2","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"5000_CR63","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","volume":"13","author":"R Laxminarayan","year":"2013","unstructured":"Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, Greko C, So AD, Bigdeli M, Tomson G, Woodhouse W, Ombaka E, Peralta AQ, Qamar FN, Mir F, Cars O (2013) Antibiotic resistance\u2014the need for global solutions. Lancet Infect Dis 13(12):1057\u20131098. https:\/\/doi.org\/10.1016\/S1473-3099(13)70318-9","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"5000_CR65","doi-asserted-by":"publisher","first-page":"999","DOI":"10.3349\/ymj.2014.55.4.999","volume":"55","author":"KE Lee","year":"2014","unstructured":"Lee KE, Han BK, Han JY, Hong JY, Kim MN, Heo WI, Sohn MH, Kim KW, Kim KE (2014) Production of egg yolk antibodies specific to house dust mite proteins. Yonsei Med J 55(4):999. https:\/\/doi.org\/10.3349\/ymj.2014.55.4.999","journal-title":"Yonsei Med J"},{"key":"5000_CR66","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jim.2017.05.001","volume":"447","author":"W Lee","year":"2017","unstructured":"Lee W, Syed Atif A, Tan SC, Leow CH (2017) Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies. J Immunol Methods 447:71\u201385. https:\/\/doi.org\/10.1016\/j.jim.2017.05.001","journal-title":"J Immunol Methods"},{"key":"5000_CR67","doi-asserted-by":"publisher","first-page":"696003","DOI":"10.3389\/fimmu.2021.696003","volume":"12","author":"L Lee","year":"2021","unstructured":"Lee L, Samardzic K, Wallach M, Frumkin LR, Mochly-Rosen D (2021) Immunoglobulin Y for potential diagnostic and therapeutic applications in infectious diseases. Front Immunol 12:696003. https:\/\/doi.org\/10.3389\/fimmu.2021.696003","journal-title":"Front Immunol"},{"key":"5000_CR68","doi-asserted-by":"publisher","first-page":"110277","DOI":"10.1016\/j.intimp.2023.110277","volume":"120","author":"CH Lee","year":"2023","unstructured":"Lee CH, Tsai CH, Leu SJ, Liu KJ, Wang WC, Tsai BY, Chiang LC, Mao YC, Dlamini NB, Tsai CH, Yang YY (2023) Generation and characterization of avian single chain variable fragment against human Alpha-Enolase. Int Immunopharmacol 120:110277. https:\/\/doi.org\/10.1016\/j.intimp.2023.110277","journal-title":"Int Immunopharmacol"},{"key":"5000_CR64","doi-asserted-by":"publisher","first-page":"111476","DOI":"10.1016\/j.intimp.2023.111476","volume":"128","author":"CH Lee","year":"2024","unstructured":"Lee CH, Wu CJ, Yang YY, Wang WC, Leu SJ, Wu CT, Chang J (2024) Characterization of chicken-derived antibody against Alpha-Enolase of Streptococcus pneumoniae. Int Immunopharmacol 128:111476. https:\/\/doi.org\/10.1016\/j.intimp.2023.111476","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"5000_CR69","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1084\/jem.130.6.1337","volume":"130","author":"GA Leslie","year":"1969","unstructured":"Leslie GA, Clem LW (1969) Phylogeny of immunoglobulin structure and function: III. Immunoglobulins of the chicken. J Exp Med 130(6):1337\u20131352. https:\/\/doi.org\/10.1084\/jem.130.6.1337","journal-title":"J Exp Med"},{"issue":"1","key":"5000_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4049\/jimmunol.110.1.1","volume":"110","author":"GA Leslie","year":"1973","unstructured":"Leslie GA, Martin LN (1973) Studies on the secretory immunologic system of fowl: III. Serum and secretory IgA of the chicken. J Immunol 110(1):1\u20139. https:\/\/doi.org\/10.4049\/jimmunol.110.1.1","journal-title":"J Immunol"},{"key":"5000_CR71","doi-asserted-by":"publisher","first-page":"1074077","DOI":"10.3389\/fimmu.2022.1074077","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, Liang T, Hei A, Wang X, Li H, Yu X, Zhao R, Gao P, Fang C, Zhou J, Li M, He E, Skog S (2022a) Novel neutralizing chicken IgY antibodies targeting 17 potent conserved peptides identified by SARS-CoV-2 proteome microarray, and future prospects. Front Immunol 13:1074077. https:\/\/doi.org\/10.3389\/fimmu.2022.1074077","journal-title":"Front Immunol"},{"issue":"10340","key":"5000_CR72","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","volume":"399","author":"Y Li","year":"2022","unstructured":"Li Y, Wang X, Blau DM, Caballero MT, Feikin DR, Gill CJ, Madhi SA, Omer SB, Sim\u00f5es EAF, Campbell H, Pariente AB, Bardach D, Bassat Q, Casalegno J-S, Chakhunashvili G, Crawford N, Danilenko D, Do LAH, Echavarria M, Nair H (2022b) Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet 399(10340):2047\u20132064. https:\/\/doi.org\/10.1016\/S0140-6736(22)00478-0","journal-title":"Lancet"},{"key":"5000_CR73","doi-asserted-by":"publisher","unstructured":"Liu D, Su J, Zhang K, Zhao S, Zhu W Preparation and detection of egg yolk antibody against Streptococcus pneumonia. In: 2010 3rd international conference on biomedical engineering and informatics 2010 Oct 16, vol. 6, IEEE. pp. 2585\u20132588. https:\/\/doi.org\/10.1109\/BMEI.2010.5639722","DOI":"10.1109\/BMEI.2010.5639722"},{"issue":"1","key":"5000_CR75","doi-asserted-by":"publisher","first-page":"9465398","DOI":"10.1155\/2020\/9465398","volume":"2020","author":"Y Lu","year":"2020","unstructured":"Lu Y, Wang Y, Zhang Z, Huang J, Yao M, Huang G, Ge Y, Zhang P, Huang H, Wang Y, Li H, Wang W (2020) Generation of chicken IgY against SARS-COV\u20102 spike protein and epitope mapping. J Immunol Res 2020(1):9465398. https:\/\/doi.org\/10.1155\/2020\/9465398","journal-title":"J Immunol Res"},{"issue":"1","key":"5000_CR74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12302-024-00858-0","volume":"36","author":"Y Luo","year":"2024","unstructured":"Luo Y, Yao Q, Ding P, Hou M, Deng F, Wang Y, Ding C, Li X, Wang D, Sun Z, Tang S, Mao Y, Yao X (2024) Health impacts of an extreme dust event: a case and risk assessment study on airborne bacteria in Beijing, China. Environ Sci Europe 36(1):41. https:\/\/doi.org\/10.1186\/s12302-024-00858-0","journal-title":"Environ Sci Europe"},{"key":"5000_CR76","doi-asserted-by":"publisher","first-page":"107797","DOI":"10.1016\/j.intimp.2021.107797","volume":"96","author":"J Lyu","year":"2021","unstructured":"Lyu J, Bao L, Shen X, Yan C, Zhang C, Wei W, Li Y (2021) The preparation of N-IgY targeting SARS-CoV-2 and its immunomodulation to IFN-\u03b3 production in vitro. Int Immunopharmacol 96:107797. https:\/\/doi.org\/10.1016\/j.intimp.2021.107797","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"5000_CR77","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/resp.14041","volume":"26","author":"M MacLeod","year":"2021","unstructured":"MacLeod M, Papi A, Contoli M, Begh\u00e9 B, Celli BR, Wedzicha JA, Fabbri LM (2021) Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact. Respirology 26(6):532\u2013551. https:\/\/doi.org\/10.1111\/resp.14041","journal-title":"Respirology"},{"issue":"12","key":"5000_CR78","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3390\/vaccines12121422","volume":"12","author":"M Madai","year":"2024","unstructured":"Madai M, Hanna D, Het\u00e9nyi R, F\u00f6ldes F, Lanszki Z, Zana B, Somogyi B, Papp H, Kuczmog A, Farag\u00f3-Sipos O, Nemes C, Palya V, Horv\u00e1th DG, Balka G, B\u00e1nyai K, Jia X, Balogh P, Bajn\u00f3czi P (2024) Evaluating the protective role of intranasally administered avian-derived IgY against SARS-CoV-2 in Syrian hamster models. Vaccines 12(12):1422. https:\/\/doi.org\/10.3390\/vaccines12121422","journal-title":"Vaccines"},{"issue":"5","key":"5000_CR79","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrmicro.2017.14","volume":"15","author":"WH Man","year":"2017","unstructured":"Man WH, De Steenhuijsen Piters WAA, Bogaert D (2017) The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol 15(5):259\u2013270. https:\/\/doi.org\/10.1038\/nrmicro.2017.14","journal-title":"Nat Rev Microbiol"},{"issue":"1\u20132","key":"5000_CR80","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jim.2011.04.013","volume":"369","author":"W Matheis","year":"2011","unstructured":"Matheis W, Schade R (2011) Development of an IgY-based rocket-immunoelectrophoresis for identity monitoring of Pertussis vaccines. J Immunol Methods 369(1\u20132):125\u2013132. https:\/\/doi.org\/10.1016\/j.jim.2011.04.013","journal-title":"J Immunol Methods"},{"key":"5000_CR81","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.3389\/fimmu.2019.02329","volume":"10","author":"J Miao","year":"2019","unstructured":"Miao J, Chard LS, Wang Z, Wang Y (2019) Syrian hamster as an animal model for the study on infectious diseases. Front Immunol 10:2329. https:\/\/doi.org\/10.3389\/fimmu.2019.02329","journal-title":"Front Immunol"},{"issue":"10","key":"5000_CR82","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1513\/AnnalsATS.201404-166OC","volume":"11","author":"PJ Mogayzel","year":"2014","unstructured":"Mogayzel PJ, Naureckas ET, Robinson KA, Brady C, Guill M, Lahiri T, Lubsch L, Matsui J, Oermann CM, Ratjen F, Rosenfeld M, Simon RH, Hazle L, Sabadosa K, Marshall BC (2014) Cystic fibrosis foundation pulmonary guideline. Pharmacologic approaches to prevention and eradication of initial Pseudomonas aeruginosa Infection. Annals Am Thorac Soc 11(10):1640\u20131650. https:\/\/doi.org\/10.1513\/AnnalsATS.201404-166OC","journal-title":"Annals Am Thorac Soc"},{"issue":"3","key":"5000_CR83","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/15321819.2022.2138718","volume":"44","author":"M Mohammadi","year":"2023","unstructured":"Mohammadi M, Zangooei M, Abbasi E, Ebrahimi Fana S, Aminian M (2023) Production of anti-tetanus toxin IgY and study of its protective effects in a mouse model. J Immunoass Immunochemistry 44(3):283\u2013295. https:\/\/doi.org\/10.1080\/15321819.2022.2138718","journal-title":"J Immunoass Immunochemistry"},{"issue":"11","key":"5000_CR84","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.3390\/ph16111615","volume":"16","author":"G Muteeb","year":"2023","unstructured":"Muteeb G, Rehman MT, Shahwan M, Aatif M (2023) Origin of antibiotics and antibiotic resistance, and their impacts on drug development: a narrative review. Pharmaceuticals 16(11):1615. https:\/\/doi.org\/10.3390\/ph16111615","journal-title":"Pharmaceuticals"},{"issue":"166","key":"5000_CR85","doi-asserted-by":"publisher","first-page":"220150","DOI":"10.1183\/16000617.0150-2022","volume":"31","author":"MS Niederman","year":"2022","unstructured":"Niederman MS, Torres A (2022) Respiratory infections. Eur Respiratory Rev 31(166):220150. https:\/\/doi.org\/10.1183\/16000617.0150-2022","journal-title":"Eur Respiratory Rev"},{"issue":"21","key":"5000_CR86","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1001\/jama.2023.8120","volume":"329","author":"T Ong","year":"2023","unstructured":"Ong T, Ramsey BW (2023) Cystic fibrosis: a review. JAMA 329(21):1859. https:\/\/doi.org\/10.1001\/jama.2023.8120","journal-title":"JAMA"},{"issue":"1","key":"5000_CR87","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/21655979.2019.1586054","volume":"10","author":"B Ozkan","year":"2019","unstructured":"Ozkan B, Budama-Kilinc Y, Cakir-Koc R, Mese S, Badur S (2019) Application of an immunoglobulin Y-alkaline phosphatase bioconjugate as a diagnostic tool for influenza A virus. Bioengineered 10(1):33\u201342. https:\/\/doi.org\/10.1080\/21655979.2019.1586054","journal-title":"Bioengineered"},{"issue":"9","key":"5000_CR88","doi-asserted-by":"publisher","first-page":"533","DOI":"10.4103\/0019-5049.165849","volume":"59","author":"A Patwa","year":"2015","unstructured":"Patwa A, Shah A (2015) Anatomy and physiology of respiratory system relevant to anaesthesia. Indian J Anaesth 59(9):533. https:\/\/doi.org\/10.4103\/0019-5049.165849","journal-title":"Indian J Anaesth"},{"issue":"4","key":"5000_CR90","doi-asserted-by":"publisher","first-page":"042002","DOI":"10.1088\/1752-7163\/ac2589","volume":"15","author":"JD Pleil","year":"2021","unstructured":"Pleil JD, Ariel Geer Wallace M, Davis MD, Matty CM (2021) The physics of human breathing: flow, timing, volume, and pressure parameters for normal, on-demand, and ventilator respiration. J Breath Res 15(4):042002. https:\/\/doi.org\/10.1088\/1752-7163\/ac2589","journal-title":"J Breath Res"},{"issue":"23","key":"5000_CR91","doi-asserted-by":"publisher","first-page":"2400301","DOI":"10.2807\/1560-7917.ES.2024.29.23.2400301","volume":"29","author":"M Poeta","year":"2024","unstructured":"Poeta M, Moracas C, Albano C, Petrarca L, Maglione M, Pierri L, Guarino A (2024) Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies. Eurosurveillance 29(23):2400301. https:\/\/doi.org\/10.2807\/1560-7917.ES.2024.29.23.2400301","journal-title":"Eurosurveillance"},{"issue":"4","key":"5000_CR92","doi-asserted-by":"publisher","first-page":"e1003587","DOI":"10.1371\/journal.pmed.1003587","volume":"18","author":"JA Polonsky","year":"2021","unstructured":"Polonsky JA, Ivey M, Mazhar MKA, Rahman Z, Waroux OlePde, Karo B, Jalava K, Vong S, Baidjoe A, Diaz J, Finger F, Habib ZH, Halder CE, Haskew C, Kaiser L, Khan AS, Sangal L, Shirin T, Zaki QA, White K (2021) Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox\u2019s Bazar, Bangladesh, 2017 to 2019: a retrospective study. PLoS Med 18(4):e1003587. https:\/\/doi.org\/10.1371\/journal.pmed.1003587","journal-title":"PLoS Med"},{"issue":"1","key":"5000_CR93","doi-asserted-by":"publisher","first-page":"9004","DOI":"10.1038\/s41598-022-12904-z","volume":"12","author":"J Poovieng","year":"2022","unstructured":"Poovieng J, Sakboonyarat B, Nasomsong W (2022) Bacterial etiology and mortality rate in community-acquired pneumonia, healthcare-associated pneumonia and hospital-acquired pneumonia in Thai university hospital. Sci Rep 12(1):9004. https:\/\/doi.org\/10.1038\/s41598-022-12904-z","journal-title":"Sci Rep"},{"key":"5000_CR94","doi-asserted-by":"publisher","first-page":"166228","DOI":"10.1016\/j.scitotenv.2023.166228","volume":"904","author":"I Pyrri","year":"2023","unstructured":"Pyrri I, Stamatelopoulou A, Pardali D, Maggos T (2023) The air and dust invisible mycobiome of urban domestic environments. Sci Total Environ 904:166228. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.166228","journal-title":"Sci Total Environ"},{"issue":"1","key":"5000_CR95","doi-asserted-by":"publisher","first-page":"2150449","DOI":"10.1080\/21505594.2022.2150449","volume":"14","author":"KC Rahlwes","year":"2023","unstructured":"Rahlwes KC, Dias BRS, Campos PC, Alvarez-Arguedas S, Shiloh MU (2023) Pathogenicity and virulence of Mycobacterium tuberculosis. Virulence 14(1):2150449. https:\/\/doi.org\/10.1080\/21505594.2022.2150449","journal-title":"Virulence"},{"issue":"5","key":"5000_CR96","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.4161\/hv.23383","volume":"9","author":"S Rahman","year":"2013","unstructured":"Rahman S, Van Nguyen S, Icatlo FC Jr, Umeda K, Kodama Y (2013) Oral passive IgY-based immunotherapeutics: a novel solution for prevention and treatment of alimentary tract diseases. Hum vaccines immunotherapeutics 9(5):1039\u20131048. https:\/\/doi.org\/10.4161\/hv.23383","journal-title":"Hum vaccines immunotherapeutics"},{"issue":"11","key":"5000_CR97","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/15459620500324453","volume":"2","author":"G Ramachandran","year":"2005","unstructured":"Ramachandran G, Adgate JL, Banerjee S, Church TR, Jones D, Fredrickson A, Sexton K (2005) Indoor air quality in two urban elementary schools\u2014measurements of airborne fungi, carpet allergens, CO2, temperature, and relative humidity. J Occup Environ Hyg 2(11):553\u2013566. https:\/\/doi.org\/10.1080\/15459620500324453","journal-title":"J Occup Environ Hyg"},{"key":"5000_CR98","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.molimm.2019.10.005","volume":"116","author":"M Ranjbar","year":"2019","unstructured":"Ranjbar M, Behrouz B, Norouzi F, Mousavi Gargari SL (2019) Anti-PcrV IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound models. Mol Immunol 116:98\u2013105. https:\/\/doi.org\/10.1016\/j.molimm.2019.10.005","journal-title":"Mol Immunol"},{"issue":"1","key":"5000_CR99","doi-asserted-by":"publisher","first-page":"12576","DOI":"10.1038\/s41598-022-16894-w","volume":"12","author":"A Ranjbar","year":"2022","unstructured":"Ranjbar A, Rasooli I, Jahangiri A, Ramezanalizadeh F (2022) Specific egg yolk antibody raised to biofilm associated protein (Bap) is protective against murine pneumonia caused by Acinetobacter baumannii. Sci Rep 12(1):12576. https:\/\/doi.org\/10.1038\/s41598-022-16894-w","journal-title":"Sci Rep"},{"issue":"10","key":"5000_CR100","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.3390\/v14102121","volume":"14","author":"E Ravlo","year":"2022","unstructured":"Ravlo E, Evensen L, Sanson G, Hildonen S, Ianevski A, Skjervold PO, Ji P, Wang W, Kaarb\u00f8 M, Kaynova GD, Kainov DE, Bj\u00f8r\u00e5s M (2022) Antiviral immunoglobulins of chicken egg yolk for potential prevention of SARS-CoV-2 infection. Viruses 14(10):2121. https:\/\/doi.org\/10.3390\/v14102121","journal-title":"Viruses"},{"issue":"18","key":"5000_CR101","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1007\/s40265-021-01635-6","volume":"81","author":"D Reynolds","year":"2021","unstructured":"Reynolds D, Kollef M (2021) The epidemiology and pathogenesis and treatment of pseudomonas aeruginosa infections: an update. Drugs 81(18):2117\u20132131. https:\/\/doi.org\/10.1007\/s40265-021-01635-6","journal-title":"Drugs"},{"issue":"1","key":"5000_CR102","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12896-021-00694-7","volume":"21","author":"M Rezaeifard","year":"2021","unstructured":"Rezaeifard M, Solhi R, Mohammadi M, Abbasi E, Aminian M (2021) Production of IgY polyclonal antibody against diphtheria toxin and evaluation of its neutralization effect by Vero cell assay. BMC Biotechnol 21(1):34. https:\/\/doi.org\/10.1186\/s12896-021-00694-7","journal-title":"BMC Biotechnol"},{"issue":"2","key":"5000_CR103","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/cc13797","volume":"18","author":"C Rodrigo","year":"2014","unstructured":"Rodrigo C, Fernando D, Rajapakse S (2014) Pharmacological management of tetanus: an evidence-based review. Crit Care 18(2):217. https:\/\/doi.org\/10.1186\/cc13797","journal-title":"Crit Care"},{"issue":"1","key":"5000_CR104","doi-asserted-by":"publisher","first-page":"e00094","DOI":"10.1128\/CMR.00094-21","volume":"35","author":"F Salazar","year":"2022","unstructured":"Salazar F, Bignell E, Brown GD, Cook PC, Warris A (2022) Pathogenesis of respiratory viral and fungal coinfections. Clin Microbiol Rev 35(1):e00094\u2013e00021. https:\/\/doi.org\/10.1128\/CMR.00094-21","journal-title":"Clin Microbiol Rev"},{"key":"5000_CR105","doi-asserted-by":"publisher","unstructured":"Sanchez-Martinez A, Moore T, Freitas TS, Benzaken TR, O\u2019Hagan S, Millar E, Groves HE, Drysdale SB, Broadbent L (2025) Recent advances in the prevention and treatment of respiratory syncytial virus disease. J Gen Virol 106(4). https:\/\/doi.org\/10.1099\/jgv.0.002095","DOI":"10.1099\/jgv.0.002095"},{"key":"5000_CR106","doi-asserted-by":"publisher","unstructured":"Saputri ME, Esfandiari A, Rachmawan WP, Soejoedono RD, Handharyani E, Jupisa C, Poetri ON (2024) Influenza immunoglobulin (Ig) Y derived from chicken egg yolk: production, characterization, and its cross-reactivity. Proc Natl Acad Sci 94(1):23\u201330. https:\/\/doi.org\/10.1007\/s40011-023-01510-2","DOI":"10.1007\/s40011-023-01510-2"},{"issue":"10","key":"5000_CR107","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1177\/1098612X19861218","volume":"21","author":"E Satyaraj","year":"2019","unstructured":"Satyaraj E, Li Q, Sun P, Sherrill S (2019) Anti-Fel d1 immunoglobulin Y antibody-containing egg ingredient lowers allergen levels in cat saliva. J Feline Med Surg 21(10):875\u2013881. https:\/\/doi.org\/10.1177\/1098612X19861218","journal-title":"J Feline Med Surg"},{"issue":"6","key":"5000_CR108","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1177\/026119299602400607","volume":"24","author":"R Schade","year":"1996","unstructured":"Schade R, Staak C, Hendriksen C, Erhard M, Hugl H, Koch G, Straughan D (1996) The production of avian (egg yolk) antibodies: IgY: the report and recommendations of ECVAM Workshop 211, 2. Altern Lab Anim 24(6):925\u2013934. https:\/\/doi.org\/10.1177\/026119299602400607","journal-title":"Altern Lab Anim"},{"issue":"2","key":"5000_CR109","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/026119290503300208","volume":"33","author":"R Schade","year":"2005","unstructured":"Schade R, Calzado EG, Sarmiento R, Chacana PA, Porankiewicz-Asplund J, Terzolo HR (2005) Chicken egg yolk antibodies (IgY-technology): a review of progress in production and use in research and human and veterinary medicine. Altern Lab Anim 33(2):129\u2013154. https:\/\/doi.org\/10.1177\/026119290503300208","journal-title":"Altern Lab Anim"},{"issue":"14","key":"5000_CR110","doi-asserted-by":"publisher","first-page":"7976","DOI":"10.3390\/ijms25147976","volume":"25","author":"J Sch\u00f6n","year":"2024","unstructured":"Sch\u00f6n J, Aebischer A, Halwe NJ, Ulrich L, Hoffmann D, Reiche S, Beer M, Grund C (2024) Evaluation of SARS-CoV-2-specific IgY antibodies: production, reactivity, and neutralizing capability against virus variants. Int J Mol Sci 25(14):7976. https:\/\/doi.org\/10.3390\/ijms25147976","journal-title":"Int J Mol Sci"},{"key":"5000_CR111","unstructured":"Schuster A (2017) Efficacy Study of IgY (Antibody Against Pseudomonas) in Cystic Fibrosis Patients (PsAer-IgY) [Internet]"},{"key":"5000_CR112","doi-asserted-by":"publisher","first-page":"115583","DOI":"10.1016\/j.biopha.2023.115583","volume":"167","author":"N Shaygankho","year":"2023","unstructured":"Shaygankho N, Jahangiri A, Rasooli I (2023) Passive immunization with anti-FimA egg yolk antibodies (IgYs) mitigate Acinetobacter baumannii pneumonia in mice. Biomed Pharmacother 167:115583. https:\/\/doi.org\/10.1016\/j.biopha.2023.115583","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"5000_CR113","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1007\/s12250-021-00371-1","volume":"36","author":"H Shen","year":"2021","unstructured":"Shen H, Cai Y, Zhang H, Wu J, Ye L, Yang P, Lin X, Jiang S, Liao M (2021) Anti-SARS-CoV-2 IgY Isolated from Egg Yolks of Hens Immunized with Inactivated SARS-CoV-2 for Immunoprophylaxis of COVID-19. Virol Sin 36(5):1080\u20131082. https:\/\/doi.org\/10.1007\/s12250-021-00371-1","journal-title":"Virol Sin"},{"key":"5000_CR114","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1016\/j.biopha.2017.09.112","volume":"95","author":"H Shi","year":"2017","unstructured":"Shi H, Zhu J, Zou B, Shi L, Du L, Long Y, Wang H, Xu H, Zhen Y, Sun L (2017) Effects of specific egg yolk immunoglobulin on pan-drug-resistant Acinetobacter baumannii. Biomed Pharmacother 95:1734\u20131742. https:\/\/doi.org\/10.1016\/j.biopha.2017.09.112","journal-title":"Biomed Pharmacother"},{"issue":"Supplement1","key":"5000_CR115","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1093\/infdis\/jiab040","volume":"226","author":"T Shi","year":"2022","unstructured":"Shi T, Vennard S, Jasiewicz F, Brogden R, Nair H, Investigators RESCEU, Nair H, Campbell H, Shi T, Li Y, Openshaw P, Beutels P, Bont L, Pollard A, Molero E, Martinon-Torres F, Heikkinen T, Meijer A, K\u00f8lsen Fischer T, Anderson L (2022) Disease burden estimates of respiratory syncytial virus related acute respiratory infections in adults with comorbidity: a systematic review and meta-analysis. J Infect Dis 226(Supplement1):S17\u2013S21. https:\/\/doi.org\/10.1093\/infdis\/jiab040","journal-title":"J Infect Dis"},{"issue":"3\u20134","key":"5000_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.vetimm.2009.12.011","volume":"135","author":"DD Silva","year":"2010","unstructured":"Silva DD, W., Tambourgi DV (2010) IgY: A promising antibody for use in immunodiagnostic and in immunotherapy. Vet Immunol Immunopathol 135(3\u20134):173\u2013180. https:\/\/doi.org\/10.1016\/j.vetimm.2009.12.011","journal-title":"Vet Immunol Immunopathol"},{"issue":"1","key":"5000_CR116","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S1473-3099(24)00430-4","volume":"25","author":"SB Sirota","year":"2025","unstructured":"Sirota SB, Doxey MC, Dominguez R-MV, Bender RG, Vongpradith A, Albertson SB, Novotney A, Burkart K, Carter A, Abdi P, Abdoun M, Abebe AM, Abegaz KH, Aboagye RG, Abolhassani H, Abreu LG, Abualruz H, Abu-Gharbieh E, Aburuz S, Kyu HH (2025) Global, regional, and national burden of upper respiratory infections and otitis media, 1990\u20132021: a systematic analysis from the Global Burden of Disease Study 2021. Lancet Infect Dis 25(1):36\u201351. https:\/\/doi.org\/10.1016\/S1473-3099(24)00430-4","journal-title":"Lancet Infect Dis"},{"key":"5000_CR117","doi-asserted-by":"publisher","first-page":"106654","DOI":"10.1016\/j.intimp.2020.106654","volume":"85","author":"R Somasundaram","year":"2020","unstructured":"Somasundaram R, Choraria A, Antonysamy M (2020) An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review. Int Immunopharmacol 85:106654. https:\/\/doi.org\/10.1016\/j.intimp.2020.106654","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"5000_CR118","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/1098612X211036793","volume":"24","author":"AH Sparkes","year":"2022","unstructured":"Sparkes AH (2022) Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control. J Feline Med Surg 24(1):31\u201342. https:\/\/doi.org\/10.1177\/1098612X211036793","journal-title":"J Feline Med Surg"},{"issue":"5","key":"5000_CR119","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/pr.pr_66_17","volume":"9","author":"S Sudjarwo","year":"2017","unstructured":"Sudjarwo S, Eraiko K, Sudjarwo G, Koerniasari (2017a) The activity of immunoglobulin Y anti-Mycobacterium tuberculosis on proliferation and cytokine expression of rat peripheral blood mononuclear cells. Pharmacognosy Res 9(5):5. https:\/\/doi.org\/10.4103\/pr.pr_66_17","journal-title":"Pharmacognosy Res"},{"issue":"3","key":"5000_CR120","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4103\/japtr.JAPTR_167_16","volume":"8","author":"S Sudjarwo","year":"2017","unstructured":"Sudjarwo S, Eraiko K, Sudjarwo G, Koerniasari (2017b) The potency of chicken egg yolk immunoglobulin (IgY) specific as immunotherapy to Mycobacterium tuberculosis infection. J Adv Pharm Tech Res 8(3):91. https:\/\/doi.org\/10.4103\/japtr.JAPTR_167_16","journal-title":"J Adv Pharm Tech Res"},{"key":"5000_CR121","doi-asserted-by":"publisher","first-page":"251513552412645","DOI":"10.1177\/25151355241264520","volume":"12","author":"AA Tabll","year":"2024","unstructured":"Tabll AA, Shahein YE, Omran MM, Hussein NA, El-Shershaby A, Petrovic A, Glasnovic M, Smolic R, Smolic M (2024) Monoclonal IgY antibodies: advancements and limitations for immunodiagnosis and immunotherapy applications. Ther Adv Vaccines Immunother 12:25151355241264520. https:\/\/doi.org\/10.1177\/25151355241264520","journal-title":"Therapeutic Adv Vaccines Immunotherapy"},{"issue":"1","key":"5000_CR122","doi-asserted-by":"publisher","first-page":"64","DOI":"10.30704\/http-www-jivs-net.1443841","volume":"8","author":"K Tetik","year":"2024","unstructured":"Tetik K (2024) Avian IgY antibodies and its immunotherapeutic applications. J Istanbul Veterinary Sci 8(1):64\u201374. https:\/\/doi.org\/10.30704\/http-www-jivs-net.1443841","journal-title":"J Istanbul Veterinary Sci"},{"issue":"7","key":"5000_CR123","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1128\/IAI.02970-14","volume":"83","author":"K Thomsen","year":"2015","unstructured":"Thomsen K, Christophersen L, Bjarnsholt T, Jensen P\u00d8, Moser C, H\u00f8iby N (2015) Anti-pseudomonas aeruginosa IgY antibodies induce specific bacterial aggregation and internalization in human polymorphonuclear neutrophils. Infect Immun 83(7):2686\u20132693. https:\/\/doi.org\/10.1128\/IAI.02970-14","journal-title":"Infect Immun"},{"issue":"2","key":"5000_CR124","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jcf.2015.08.002","volume":"15","author":"K Thomsen","year":"2016","unstructured":"Thomsen K, Christophersen L, Bjarnsholt T, Jensen P\u00d8, Moser C, H\u00f8iby N (2016) Anti-pseudomonas aeruginosa IgY antibodies augment bacterial clearance in a murine pneumonia model. J Cyst Fibros 15(2):171\u2013178. https:\/\/doi.org\/10.1016\/j.jcf.2015.08.002","journal-title":"J Cyst Fibros"},{"issue":"1","key":"5000_CR125","doi-asserted-by":"publisher","first-page":"106213","DOI":"10.1016\/j.ijantimicag.2020.106213","volume":"57","author":"K Thomsen","year":"2021","unstructured":"Thomsen K, Christophersen L, Lerche CJ, Holmgaard DB, Calum H, H\u00f8iby N, Moser C (2021) Azithromycin potentiates avian IgY effect against Pseudomonas aeruginosa in a murine pulmonary infection model. Int J Antimicrob Agents 57(1):106213. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.106213","journal-title":"Int J Antimicrob Agents"},{"key":"5000_CR126","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.enbuild.2017.04.048","volume":"146","author":"D Tudiwer","year":"2017","unstructured":"Tudiwer D, Korjenic A (2017) The effect of an indoor living wall system on humidity, mould spores and CO 2 -concentration. Energy Build 146:73\u201386. https:\/\/doi.org\/10.1016\/j.enbuild.2017.04.048","journal-title":"Energy Build"},{"key":"5000_CR127","doi-asserted-by":"publisher","unstructured":"Wang H, Charles CV (2020) A review of newly approved antibiotic treatment for community-acquired bacterial pneumonia: lefamulin. Senior Care Pharm 35(8):349\u2013354. https:\/\/doi.org\/10.4140\/TCP.n.2020.349","DOI":"10.4140\/TCP.n.2020.349"},{"key":"5000_CR128","unstructured":"Wardani G, Eraiko K, Koerniasari K, Sudjarwo SA (2019) Evaluation acute and subacute oral toxicity of Immunoglobulin Y anti Mycobacterium tuberculosis in Wistar rats"},{"issue":"8","key":"5000_CR129","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/0167-5699(95)80008-5","volume":"16","author":"GW Warr","year":"1995","unstructured":"Warr GW, Magor KE, Higgins DA (1995) IgY: clues to the origins of modern antibodies. Immunol Today 16(8):392\u2013398. https:\/\/doi.org\/10.1016\/0167-5699(95)80008-5","journal-title":"Immunol Today"},{"key":"5000_CR130","doi-asserted-by":"publisher","DOI":"10.1101\/2021.02.16.430255","author":"J Wei","year":"2021","unstructured":"Wei J, Lu Y, Rui Y, Zhu X, He S, Wu S, Xu Q (2021a) A chicken IgY can efficiently inhibit the entry and replication of SARS-CoV-2 by targeting the ACE2 binding domain in vitro. Immunology. https:\/\/doi.org\/10.1101\/2021.02.16.430255","journal-title":"Immunology"},{"key":"5000_CR131","doi-asserted-by":"publisher","first-page":"107172","DOI":"10.1016\/j.intimp.2020.107172","volume":"90","author":"S Wei","year":"2021","unstructured":"Wei S, Duan S, Liu X, Wang H, Ding S, Chen Y, Xie J, Tian J, Yu N, Ge P, Zhang X, Chen X, Li Y, Meng Q (2021b) Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2. Int Immunopharmacol 90:107172. https:\/\/doi.org\/10.1016\/j.intimp.2020.107172","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"5000_CR135","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.molimm.2013.11.006","volume":"58","author":"H Wei-xu","year":"2014","unstructured":"Wei-xu H, Qin X, Zhu W, Yuan-yi C, Li-feng Z, Zhi-yong L, Dan H, Xiao-mu W, Guo-zhu H (2014) Therapeutic potential of anti-IL-1\u03b2 IgY in guinea pigs with allergic asthma induced by ovalbumin. Mol Immunol 58(1):139\u2013149. https:\/\/doi.org\/10.1016\/j.molimm.2013.11.006","journal-title":"Mol Immunol"},{"key":"5000_CR136","doi-asserted-by":"publisher","unstructured":"Wei-xu H, Wen-yun Z, Xi-ling Z, Zhu W, Li-hua W, Xiao-mu W, Hui-ping W, Wen-ding W, Dan H, Qin X, Guo-zhu H (2016) Anti-Interleukin-1 beta\/tumor necrosis factor-alpha IgY antibodies reduce pathological allergic responses in guinea pigs with allergic rhinitis. Mediators Inflammation 2016:1\u201311. https:\/\/doi.org\/10.1155\/2016\/3128182","DOI":"10.1155\/2016\/3128182"},{"issue":"1","key":"5000_CR132","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/cei.12822","volume":"187","author":"B Weinberger","year":"2016","unstructured":"Weinberger B (2016) Adult vaccination against tetanus and diphtheria: the European perspective. Clin Exp Immunol 187(1):93\u201399. https:\/\/doi.org\/10.1111\/cei.12822","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"5000_CR133","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41579-018-0001-8","volume":"16","author":"JN Weiser","year":"2018","unstructured":"Weiser JN, Ferreira DM, Paton JC (2018) Streptococcus pneumoniae: transmission, colonization and invasion. Nat Rev Microbiol 16(6):355\u2013367. https:\/\/doi.org\/10.1038\/s41579-018-0001-8","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"5000_CR134","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1128\/MMBR.69.4.635-664.2005","volume":"69","author":"SR Weiss","year":"2005","unstructured":"Weiss SR, Navas-Martin S (2005) Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 69(4):635\u2013664. https:\/\/doi.org\/10.1128\/MMBR.69.4.635-664.2005","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"5000_CR137","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.antiviral.2011.11.005","volume":"93","author":"J Wen","year":"2012","unstructured":"Wen J, Zhao S, He D, Yang Y, Li Y, Zhu S (2012) Preparation and characterization of egg yolk immunoglobulin Y specific to influenza B virus. Antiviral Res 93(1):154\u2013159. https:\/\/doi.org\/10.1016\/j.antiviral.2011.11.005","journal-title":"Antiviral Res"},{"issue":"1","key":"5000_CR138","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3390\/vaccines100101","volume":"10","author":"H Wongso","year":"2022","unstructured":"Wongso H, Mahendra I, Arnafia W, Idar I, Yusuf M, Achmad A, Holik HA, Kurniawan A, Halimah I, Sriyani ME, Wibawa THA, Febrian MB, Setiadi Y, Widyasari EM, Daruwati I, Kusumaningrum CE, Subroto T (2022) Preclinical evaluation of chicken egg yolk antibody (IgY) anti-RBD spike SARS-CoV-2\u2014a candidate for passive immunization against COVID-19. Vaccines 10(1):128. https:\/\/doi.org\/10.3390\/vaccines100101","journal-title":"Vaccines"},{"issue":"1","key":"5000_CR139","doi-asserted-by":"publisher","first-page":"23912","DOI":"10.1038\/s41598-024-73209-x","volume":"14","author":"TW Wotale","year":"2024","unstructured":"Wotale TW, Lelisho ME, Negasa BW, Tareke SA, Gobena WE, Amesa EG (2024) Identifying risk factors for recurrent multidrug resistant tuberculosis based on patient\u2019s record data from 2016 to 2021: Retrospective study. Sci Rep 14(1):23912. https:\/\/doi.org\/10.1038\/s41598-024-73209-x","journal-title":"Sci Rep"},{"key":"5000_CR140","doi-asserted-by":"publisher","first-page":"991931","DOI":"10.3389\/fimmu.2022.991931","volume":"13","author":"S Yakhkeshi","year":"2022","unstructured":"Yakhkeshi S, Wu R, Chelliappan B, Zhang X (2022) Trends in industrialization and commercialization of IgY technology. Front Immunol 13:991931. https:\/\/doi.org\/10.3389\/fimmu.2022.991931","journal-title":"Front Immunol"},{"key":"5000_CR141","doi-asserted-by":"publisher","first-page":"140291","DOI":"10.1016\/j.ijbiomac.2025.140291","volume":"300","author":"S Yakhkeshi","year":"2025","unstructured":"Yakhkeshi S, Isah MB, Sadeghi-Abandansari H, Zhang X (2025) Advances in IgY antibody dosage form design and delivery strategies: Current status and future perspective. Int J Biol Macromol 300:140291. https:\/\/doi.org\/10.1016\/j.ijbiomac.2025.140291","journal-title":"Int J Biol Macromol"},{"key":"5000_CR142","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jviromet.2014.05.016","volume":"206","author":"Y Yang","year":"2014","unstructured":"Yang Y, Wen J, Zhao S, Zhang K, Zhou Y (2014) Prophylaxis and therapy of pandemic H1N1 virus infection using egg yolk antibody. J Virol Methods 206:19\u201326. https:\/\/doi.org\/10.1016\/j.jviromet.2014.05.016","journal-title":"J Virol Methods"},{"issue":"11","key":"5000_CR143","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.3390\/biomedicines10112774","volume":"10","author":"C-T Yeh","year":"2022","unstructured":"Yeh C-T, Lee C-Y, Ho Y-J, Chen S-A, Chen L-Y, Liu P-C, Chin Y-F, Chen A-Y, Hsieh P-S, Hung Y-J, Chen C-C, Wang Y-C, Lee G-C (2022) Immunoglobulin Y specific for SARS-CoV-2 spike protein subunits effectively neutralizes SARS-CoV-2 infectivity and ameliorates disease manifestations in vivo. Biomedicines 10(11):2774. https:\/\/doi.org\/10.3390\/biomedicines10112774","journal-title":"Biomedicines"},{"issue":"1","key":"5000_CR144","doi-asserted-by":"publisher","first-page":"122","DOI":"10.54254\/2753-8818\/45\/20240524","volume":"45","author":"L Yue","year":"2024","unstructured":"Yue L (2024) Streptococcus pneumoniae: virulence factor, pathogenesis, and two typical drugs with distinctive mechanism. Theoretical Nat Sci 45(1):122\u2013129. https:\/\/doi.org\/10.54254\/2753-8818\/45\/20240524","journal-title":"Theoretical Nat Sci"},{"issue":"8","key":"5000_CR145","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/s1359-6446(03)02655-2","volume":"8","author":"WW Zhang","year":"2003","unstructured":"Zhang WW (2003) The use of gene-specific IgY antibodies for drug target discovery. Drug Discov Today 8(8):364\u2013371. https:\/\/doi.org\/10.1016\/s1359-6446(03)02655-2","journal-title":"Drug Discovery Today"},{"issue":"4","key":"5000_CR146","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1111\/brv.12325","volume":"92","author":"X Zhang","year":"2017","unstructured":"Zhang X, Calvert RA, Sutton BJ, Dor\u00e9 KA (2017) IgY: A key isotype in antibody evolution. Biol Rev 92(4):2144\u20132156. https:\/\/doi.org\/10.1111\/brv.12325","journal-title":"Biol Rev"},{"issue":"8","key":"5000_CR147","doi-asserted-by":"publisher","first-page":"102843","DOI":"10.1016\/j.psj.2023.102843","volume":"102","author":"X Zhang","year":"2023","unstructured":"Zhang X, Wu R, Chelliappan B (2023) Proteomic investigation and understanding on IgY purification and product development. Poult Sci 102(8):102843. https:\/\/doi.org\/10.1016\/j.psj.2023.102843","journal-title":"Poult Sci"},{"issue":"1","key":"5000_CR148","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40659-024-00508-y","volume":"57","author":"B Zhao","year":"2024","unstructured":"Zhao B, Peng H, Zhang Y, Zhang J, Kong D, Cao S, Li Y, Yang D, Sun C, Pu X, Zhao P, Xu Y, Zhao K, Xie L (2024) Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters. Biol Res 57(1):24. https:\/\/doi.org\/10.1186\/s40659-024-00508-y","journal-title":"Biol Res"},{"key":"5000_CR149","doi-asserted-by":"publisher","unstructured":"Zhu Z, Zhu X, Chu Y, Zhang B, Chen Y (2025) Comparative effectiveness of oral nutritional supplements in preventing respiratory tract infections among adults: a systematic review and network meta-analysis. EClinicalMedicine 88. https:\/\/doi.org\/10.1016\/j.eclinm.2025.103479","DOI":"10.1016\/j.eclinm.2025.103479"},{"issue":"3\u20134","key":"5000_CR150","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/BF01317370","volume":"90","author":"M Zrein","year":"1986","unstructured":"Zrein M, Obert G, Van Regenmortel MHV (1986) Use of egg-yolk antibody for detection of respiratory syncytial virus in nasal secretions by ELISA. Arch Virol 90(3\u20134):197\u2013206. https:\/\/doi.org\/10.1007\/BF01317370","journal-title":"Arch Virol"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05000-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05000-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05000-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:26:36Z","timestamp":1787909196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-026-05000-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":149,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5000"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-05000-7","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"19 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"432"}}