{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:20:42Z","timestamp":1787988042543,"version":"build-2784847793"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00203-026-05038-7","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:59:26Z","timestamp":1787986766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cEdible plant-associated fungal endophytes as sources of bioactive specialized metabolites: antimicrobial and docking insights\u201d"],"prefix":"10.1007","volume":"208","author":[{"given":"Hala Montaser","family":"Farouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feby Melad","family":"Gaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Al-Karmalawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo\u2019men Hamed","family":"El-Katatny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Zekry","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Menshawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"5038_CR1","doi-asserted-by":"publisher","first-page":"6172","DOI":"10.1007\/s12011-025-04632-y","volume":"203","author":"WIE Abdel-Badeea","year":"2025","unstructured":"Abdel-Badeea WIE, Abdel-Wahab A, Mahmoud AA et al (2025) Syzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204\u20135p-Mediated Bcl- 2 Upregulation and Bax\/Caspase 9\/Caspase 3 Downregulation. Biol Trace Elem Res 203:6172\u20136191. https:\/\/doi.org\/10.1007\/s12011-025-04632-y","journal-title":"Biol Trace Elem Res"},{"key":"5038_CR2","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3390\/pr8040470","volume":"8","author":"AS Abdel-Razek","year":"2020","unstructured":"Abdel-Razek AS, El-Naggar ME, Allam A et al (2020) Microbial Natural Products in Drug Discovery. Processes 8:470. https:\/\/doi.org\/10.3390\/pr8040470","journal-title":"Processes"},{"key":"5038_CR3","doi-asserted-by":"publisher","first-page":"4906","DOI":"10.1128\/AEM.68.10.4906-4914.2002","volume":"68","author":"WL Ara\u00fajo","year":"2002","unstructured":"Ara\u00fajo WL, Marcon J, Maccheroni W et al (2002) Diversity of endophytic bacterial populations and their interaction with Xylella fastidiosa in citrus plants. Appl Environ Microbiol 68:4906\u20134914. https:\/\/doi.org\/10.1128\/AEM.68.10.4906-4914.2002","journal-title":"Appl Environ Microbiol"},{"key":"5038_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2147\/DDDT.S354841","volume":"16","author":"NA Ashour","year":"2022","unstructured":"Ashour NA, Elmaaty AA, Sarhan AA, Elkaeed EB, Moussa AM, Erfan IA, Al-Karmalawy AA (2022) A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval. Drug Des Devel Ther 16:685","journal-title":"Drug Des Devel Ther"},{"key":"5038_CR5","first-page":"455","volume":"38","author":"SY Athman","year":"2006","unstructured":"Athman SY, Dubois T, Coyne D et al (2006) Effect of Endophytic Fusarium oxysporum on Host Preference of Radopholus similis to Tissue Culture Banana Plants. J Nematol 38:455\u2013460","journal-title":"J Nematol"},{"key":"5038_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1292\/jvms.16-0008","volume":"79","author":"S Aupanun","year":"2017","unstructured":"Aupanun S, Poapolathep S, Giorgi M et al (2017) An overview of the toxicology and toxicokinetics of fusarenon-X, a type B trichothecene mycotoxin. J Vet Med Sci 79:6\u201313. https:\/\/doi.org\/10.1292\/jvms.16-0008","journal-title":"J Vet Med Sci"},{"key":"5038_CR7","doi-asserted-by":"publisher","first-page":"762021","DOI":"10.1155\/2014\/762021","volume":"2014","author":"HS Auta","year":"2014","unstructured":"Auta HS, Abidoye KT, Tahir H et al (2014) Citric Acid Production by Aspergillus niger Cultivated on Parkia biglobosa Fruit Pulp. Int Sch Res Notices 2014:762021. https:\/\/doi.org\/10.1155\/2014\/762021","journal-title":"Int Sch Res Notices"},{"key":"5038_CR8","volume-title":"Illustrated Genera of Imperfect Fungi","author":"HL Barnett","year":"1972","unstructured":"Barnett HL, Hunter BB (1972) Illustrated Genera of Imperfect Fungi. Burgess Publishing Company., Minnesota"},{"key":"5038_CR10","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","volume":"45","author":"AW Bauer","year":"1966","unstructured":"Bauer AW, Kirby WM, Sherris JC, Turck M (1966) Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 45:493\u2013496","journal-title":"Am J Clin Pathol"},{"key":"5038_CR11","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.3390\/molecules27113584","volume":"27","author":"A Belal","year":"2022","unstructured":"Belal A, Elanany MA, Santali EY et al (2022) Screening a Panel of Topical Ophthalmic Medications against MMP-2 and MMP-9 to Investigate Their Potential in Keratoconus Management. Molecules 27:3584. https:\/\/doi.org\/10.3390\/molecules27113584","journal-title":"Molecules"},{"key":"5038_CR9","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1128\/CMR.16.3.497-516.2003","volume":"16","author":"JW Bennett","year":"2003","unstructured":"Bennett JW, Klich M (2003) Mycotoxins. Clin Microbiol Rev 16:497\u2013516","journal-title":"Clin Microbiol Rev"},{"key":"5038_CR12","doi-asserted-by":"publisher","unstructured":"Caruso DJ, Palombo EA, Moulton SE, Zaferanloo B (2022) Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds. https:\/\/doi.org\/10.3390\/microorganisms10101990. Microorganisms 10:1990","DOI":"10.3390\/microorganisms10101990"},{"key":"5038_CR13","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1080\/14756366.2022.2063282","volume":"37","author":"RR Ezz Eldin","year":"2022","unstructured":"Ezz Eldin RR, Saleh MA, Alotaibi MH et al (2022) Ligand-based design and synthesis of N\u2019-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies. J Enzyme Inhib Med Chem 37:1098\u20131119. https:\/\/doi.org\/10.1080\/14756366.2022.2063282","journal-title":"J Enzyme Inhib Med Chem"},{"key":"5038_CR14","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.sajb.2023.08.071","volume":"162","author":"HM Farouk","year":"2023","unstructured":"Farouk HM, Hashem ZS, Attia EZ, Shaban GM, Glaeser SP, K\u00e4mpfer P, Abdelmohsen UR, El-Katatny MH (2023) Bioactivity of crude extract produced by endophytic fungi isolated from Ziziphus spina-christi (Nabq) leaves for antimicrobial evaluation as well as optimization of culture medium conditions. South Afr J Bot 162:873\u2013884","journal-title":"South Afr J Bot"},{"key":"5038_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10010147","author":"NA Foroud","year":"2009","unstructured":"Foroud NA, Eudes F (2009) Trichothecenes in Cereal Grains. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms10010147","journal-title":"Int J Mol Sci"},{"key":"5038_CR16","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1271\/bbb.57.1222","volume":"57","author":"Y Fujimoto","year":"1993","unstructured":"Fujimoto Y, Miyagawa H, Tsurushima T et al (1993) Structures of Antafumicins A and B, Novel Antifungal Substances Produced by the Fungus Aspergillus niger NH-401. Biosci Biotechnol Biochem 57:1222\u20131224. https:\/\/doi.org\/10.1271\/bbb.57.1222","journal-title":"Biosci Biotechnol Biochem"},{"key":"5038_CR17","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3390\/jof7100786","volume":"7","author":"MM Gakuubi","year":"2021","unstructured":"Gakuubi MM, Munusamy M, Liang Z-X, Ng SB (2021) Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds. J Fungi (Basel) 7:786. https:\/\/doi.org\/10.3390\/jof7100786","journal-title":"J Fungi (Basel)"},{"key":"5038_CR18","doi-asserted-by":"publisher","first-page":"100332","DOI":"10.1016\/j.rhisph.2021.100332","volume":"18","author":"RMS Galeano","year":"2021","unstructured":"Galeano RMS, Franco DG, Chaves PO et al (2021) Plant growth promoting potential of endophytic Aspergillus niger 9-p isolated from native forage grass in Pantanal of Nhecol\u00e2ndia region, Brazil. Rhizosphere 18:100332. https:\/\/doi.org\/10.1016\/j.rhisph.2021.100332","journal-title":"Rhizosphere"},{"key":"5038_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/J.Sajb.2023.08.024","volume":"161","author":"F Ghaffari","year":"2023","unstructured":"Ghaffari F, Ebadi M, Mollaei S (2023) Isolation and Molecular Identification of Endophytic Fungi Associated with Ziziphora Tenuior L and Their Biological Potential. South Afr J Bot 161:358\u2013364. https:\/\/doi.org\/10.1016\/J.Sajb.2023.08.024","journal-title":"South Afr J Bot"},{"key":"5038_CR20","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.3389\/fmicb.2016.01538","volume":"7","author":"S Gouda","year":"2016","unstructured":"Gouda S, Das G, Sen SK et al (2016) Endophytes: A Treasure House of Bioactive Compounds of Medicinal Importance. Front Microbiol 7:1538. https:\/\/doi.org\/10.3389\/fmicb.2016.01538","journal-title":"Front Microbiol"},{"key":"5038_CR21","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/plants11030384","volume":"11","author":"R Grabka","year":"2022","unstructured":"Grabka R, d\u2019Entremont TW, Adams SJ et al (2022) Fungal Endophytes and Their Role in Agricultural Plant Protection against Pests and Pathogens. Plants (Basel) 11:384. https:\/\/doi.org\/10.3390\/plants11030384","journal-title":"Plants (Basel)"},{"key":"5038_CR22","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1039\/P19790002048","volume":"1","author":"JF Grove","year":"1979","unstructured":"Grove JF, Pople M (1979) Metabolic products of Fusarium larvarum fuckel. The fusarentins and the absolute configuration of monocerin. J Chem Soc Perkin Trans 1:2048\u20132051. https:\/\/doi.org\/10.1039\/P19790002048","journal-title":"J Chem Soc Perkin Trans"},{"key":"5038_CR24","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1080\/14786419.2023.2167204","volume":"37","author":"HA Hassan","year":"2023","unstructured":"Hassan HA, Abdelhafez OH, Shady NH et al (2023) The anti-infective potential of the endophytic fungi associated with Allium cepa supported by metabolomics analysis and docking studies. Nat Prod Res 37:4063\u20134068. https:\/\/doi.org\/10.1080\/14786419.2023.2167204","journal-title":"Nat Prod Res"},{"key":"5038_CR25","doi-asserted-by":"crossref","unstructured":"Jha P, Kaur T, Chhabra I, Panja A, Paul S, Kumar V, Malik T (2023) Endophytic fungi: hidden treasure chest of antimicrobial metabolites interrelationship of endophytes and metabolites. Front Microbiol Volume 14\u20132023","DOI":"10.3389\/fmicb.2023.1227830"},{"key":"5038_CR26","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S0006-291X(74)80266-4","volume":"56","author":"G Kishore","year":"1974","unstructured":"Kishore G, Sugumaran M, Vaidyanathan CS (1974) p-hydroxymandelic acid \u2014 a key intermediate in the metabolism of DL(+)-phenylalanine by aspergillusniger. Biochem Biophys Res Commun 56:851\u2013859. https:\/\/doi.org\/10.1016\/S0006-291X(74)80266-4","journal-title":"Biochem Biophys Res Commun"},{"key":"5038_CR27","doi-asserted-by":"publisher","first-page":"42","DOI":"10.7164\/antibiotics.48.42","volume":"48","author":"H Kobayashi","year":"1995","unstructured":"Kobayashi H, Sunaga R, Furihata K et al (1995) Isolation and structures of an antifungal antibiotic, fusarielin A, and related compounds produced by a Fusarium sp. J Antibiot (Tokyo) 48:42\u201352. https:\/\/doi.org\/10.7164\/antibiotics.48.42","journal-title":"J Antibiot (Tokyo)"},{"key":"5038_CR28","doi-asserted-by":"publisher","first-page":"7540","DOI":"10.1016\/j.tet.2011.07.078","volume":"67","author":"J Kornsakulkarn","year":"2011","unstructured":"Kornsakulkarn J, Dolsophon K, Boonyuen N et al (2011) Dihydronaphthalenones from endophytic fungus Fusarium sp. BCC14842. Tetrahedron 67:7540\u20137547. https:\/\/doi.org\/10.1016\/j.tet.2011.07.078","journal-title":"Tetrahedron"},{"key":"5038_CR29","doi-asserted-by":"crossref","unstructured":"Kowalska-Krochmal B, Dudek-Wicher R (2021) The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance. Pathogens 10","DOI":"10.3390\/pathogens10020165"},{"key":"5038_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.7164\/antibiotics.39.205","volume":"39","author":"I Kurobane","year":"1986","unstructured":"Kurobane I, Zaita N, Fukuda A (1986) New metabolites of Fusarium martii related to dihydrofusarubin. J Antibiot (Tokyo) 39:205\u2013214. https:\/\/doi.org\/10.7164\/antibiotics.39.205","journal-title":"J Antibiot (Tokyo)"},{"key":"5038_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1574-6968.2009.01719.x","volume":"299","author":"K Lee","year":"2009","unstructured":"Lee K, Pan JJ, May G (2009) Endophytic Fusarium verticillioides reduces disease severity caused by Ustilago maydis on maize. FEMS Microbiol Lett 299:31\u201337. https:\/\/doi.org\/10.1111\/j.1574-6968.2009.01719.x","journal-title":"FEMS Microbiol Lett"},{"key":"5038_CR32","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/10286020802031106","volume":"10","author":"L-Y Li","year":"2008","unstructured":"Li L-Y, Ding Y, Groth I et al (2008) Pyrrole and indole alkaloids from an endophytic Fusarium incarnatum (HKI00504) isolated from the mangrove plant Aegiceras corniculatum. J Asian Nat Prod Res 10:775\u2013780. https:\/\/doi.org\/10.1080\/10286020802031106","journal-title":"J Asian Nat Prod Res"},{"key":"5038_CR33","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.3390\/ijms24021153","volume":"24","author":"Z Li","year":"2023","unstructured":"Li Z, Xiong K, Wen W et al (2023) Functional Endophytes Regulating Plant Secondary Metabolism: Current Status, Prospects and Applications. Int J Mol Sci 24:1153. https:\/\/doi.org\/10.3390\/ijms24021153","journal-title":"Int J Mol Sci"},{"key":"5038_CR34","doi-asserted-by":"publisher","unstructured":"Liao C, Doilom M, Jeewon R et al (2025) Challenges and update on fungal endophytes: classification, definition, diversity, ecology, evolution and functions. Fungal Divers 131. https:\/\/doi.org\/10.1007\/s13225-025-00550-5","DOI":"10.1007\/s13225-025-00550-5"},{"key":"5038_CR35","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s13562-025-00978-5","volume":"34","author":"J Lim","year":"2025","unstructured":"Lim J, Kim JK, Kim K, Kwon H, Seo H, Sathasivam R, Park SU, Park C (2025) Comparative analysis of secondary metabolites and antioxidant activities in white and red radish (Raphanus sativus) hairy roots. J Plant Biochem Biotechnol 34:774\u2013784","journal-title":"J Plant Biochem Biotechnol"},{"key":"5038_CR36","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1021\/np200381u","volume":"74","author":"D Liu","year":"2011","unstructured":"Liu D, Li X-M, Meng L et al (2011) Nigerapyrones A-H, \u03b1-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. J Nat Prod 74:1787\u20131791. https:\/\/doi.org\/10.1021\/np200381u","journal-title":"J Nat Prod"},{"key":"5038_CR38","doi-asserted-by":"publisher","unstructured":"Mahmoud A, Kotb E, Alqosaibi AI et al (2021a) In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia. Heliyon 7:e08148. https:\/\/doi.org\/10.1016\/j.heliyon.2021.e08148","DOI":"10.1016\/j.heliyon.2021.e08148"},{"key":"5038_CR39","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1208\/s12249-021-02197-2","volume":"23","author":"DB Mahmoud","year":"2021","unstructured":"Mahmoud DB, Bakr MM, Al-karmalawy AA et al (2021b) Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19. AAPS PharmSciTech 23:44. https:\/\/doi.org\/10.1208\/s12249-021-02197-2","journal-title":"AAPS PharmSciTech"},{"key":"5038_CR40","doi-asserted-by":"publisher","unstructured":"Manganyi MC, Ateba CN (2020) Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications. Microorganisms 8:1934. https:\/\/doi.org\/10.3390\/microorganisms8121934","DOI":"10.3390\/microorganisms8121934"},{"key":"5038_CR41","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0031-9422(98)00596-2","volume":"50","author":"O Miersch","year":"1999","unstructured":"Miersch O, Bohlmann H, Wasternack C (1999) Jasmonates and related compounds from Fusarium oxysporum. Phytochemistry 50:517\u2013523. https:\/\/doi.org\/10.1016\/S0031-9422(98)00596-2","journal-title":"Phytochemistry"},{"key":"5038_CR42","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/bacteria5010016","volume":"5","author":"L Miloudi-Agha","year":"2026","unstructured":"Miloudi-Agha L, Kebdani M (2026) Mechanisms Underpinning the Biocontrol Potential of Halophilic and Halotolerant Bacillus Species Against Fusarium and Other Fungal Phytopathogens: An Eco-Friendly Alternative for Sustainable Agriculture. Bacteria 5:16. https:\/\/doi.org\/10.3390\/bacteria5010016","journal-title":"Bacteria"},{"key":"5038_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/foods14234148","author":"F Monzillo","year":"2025","unstructured":"Monzillo F, Della Mura B, Matarazzo C, Crescenzi MA, Piacente S, d\u2019Aquino L, Cozzolino R, Montoro P (2025) Evolution of Secondary Metabolites in Eruca sativa from the Microgreen to the Reproductive Stage: An Integrative Multi-Platform Metabolomics Approach. Foods. https:\/\/doi.org\/10.3390\/foods14234148","journal-title":"Foods"},{"key":"5038_CR44","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJL Murray","year":"2022","unstructured":"Murray CJL, Ikuta KS, Sharara F et al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399:629\u2013655. https:\/\/doi.org\/10.1016\/S0140-6736(21)02724-0","journal-title":"Lancet"},{"key":"5038_CR45","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1016\/0031-9422(88)80021-9","volume":"27","author":"MG Nair","year":"1988","unstructured":"Nair MG, Burke BA (1988) A new fatty acid methyl ester and other biologically active compounds from Aspergillus niger. Phytochemistry 27:3169\u20133173. https:\/\/doi.org\/10.1016\/0031-9422(88)80021-9","journal-title":"Phytochemistry"},{"key":"5038_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/applmicrobiol5010005","volume":"5","author":"AA Najjar","year":"2025","unstructured":"Najjar AA (2025) Therapeutic Potential of Endophytic Microbes: Emphasizing Both Fungal and Bacterial Endophytes. Appl Microbiol 5:5. https:\/\/doi.org\/10.3390\/applmicrobiol5010005","journal-title":"Appl Microbiol"},{"key":"5038_CR47","doi-asserted-by":"publisher","unstructured":"Nei M, Kumar S (2000) Molecular Evolution and Phylogenetics. Oxford University Press. https:\/\/doi.org\/10.1093\/oso\/9780195135848.001.0001","DOI":"10.1093\/oso\/9780195135848.001.0001"},{"key":"5038_CR48","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1016\/0040-4039(92)88083-H","volume":"33","author":"D Niederer","year":"1992","unstructured":"Niederer D, Tamm C, Z\u00fcrcher W (1992) Nitrogen containing metabolites of fusarium sambucinum. Tetrahedron Lett 33:3997\u20134000. https:\/\/doi.org\/10.1016\/0040-4039(92)88083-H","journal-title":"Tetrahedron Lett"},{"key":"5038_CR49","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00204-010-0579-8","volume":"84","author":"JJ Pestka","year":"2010","unstructured":"Pestka JJ (2010) Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Arch Toxicol 84:663\u2013679","journal-title":"Arch Toxicol"},{"key":"5038_CR51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1080\/21501203.2020.1870579","volume":"12","author":"N Rai","year":"2021","unstructured":"Rai N, Kumari Keshri P, Verma A et al (2021) Plant associated fungal endophytes as a source of natural bioactive compounds. Mycology 12:139\u2013159. https:\/\/doi.org\/10.1080\/21501203.2020.1870579","journal-title":"Mycology"},{"key":"5038_CR50","doi-asserted-by":"crossref","unstructured":"Ramirez D, Abell\u00e1n-Victorio A, Beretta V, Camargo A, Moreno DA (2020) Functional Ingredients From Brassicaceae Species: Overview and Perspectives. Int J Mol Sci 21","DOI":"10.3390\/ijms21061998"},{"key":"5038_CR52","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1128\/aem.53.2.457-459.1987","volume":"53","author":"KE Richardson","year":"1987","unstructured":"Richardson KE, Hamilton PB (1987) Preparation of scirpentriol and triacetoxyscirpenol in good yield from cultures of Fusarium sambucinum NRRL 13495. Appl Environ Microbiol 53:457\u2013459. https:\/\/doi.org\/10.1128\/aem.53.2.457-459.1987","journal-title":"Appl Environ Microbiol"},{"key":"5038_CR53","doi-asserted-by":"publisher","first-page":"e0027224","DOI":"10.1128\/aac.00272-24","volume":"68","author":"CM Rotondo","year":"2024","unstructured":"Rotondo CM, Wright GD (2024) Efficacy of aspergillomarasmine A\/meropenem combinations with and without avibactam against bacterial strains producing multiple \u03b2-lactamases. Antimicrob Agents Chemother 68:e0027224. https:\/\/doi.org\/10.1128\/aac.00272-24","journal-title":"Antimicrob Agents Chemother"},{"key":"5038_CR54","doi-asserted-by":"crossref","unstructured":"Salah H, Houbraken J, Boekhout T, Almaslamani M, Taj-Aldeen SJ (2022) Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and fusarium with notes on the rare species. Med Mycol. 61(1). Epub 2023\/01\/03.","DOI":"10.1093\/mmy\/myac098"},{"key":"5038_CR55","doi-asserted-by":"publisher","first-page":"5215","DOI":"10.1016\/S0040-4020(01)98730-7","volume":"26","author":"EP Sbrebryakov","year":"1970","unstructured":"Sbrebryakov EP, Simolin AV, Kucherov VF, Rosynov BV (1970) New metabolites of Fusarium moniliforme sheld. Tetrahedron 26:5215\u20135223. https:\/\/doi.org\/10.1016\/S0040-4020(01)98730-7","journal-title":"Tetrahedron"},{"key":"5038_CR56","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/S0953-7562(09)80215-3","volume":"97","author":"B Schulz","year":"1993","unstructured":"Schulz B, Wanke U, Draeger S, Aust H-J (1993) Endophytes from herbaceous plants and shrubs: effectiveness of surface sterilization methods. Mycol Res 97:1447\u20131450. https:\/\/doi.org\/10.1016\/S0953-7562(09)80215-3","journal-title":"Mycol Res"},{"key":"5038_CR57","doi-asserted-by":"publisher","first-page":"e19487","DOI":"10.1016\/j.heliyon.2023.e19487","volume":"9","author":"I Sharma","year":"2023","unstructured":"Sharma I, Raina A, Choudhary M et al (2023) Fungal endophyte bioinoculants as a green alternative towards sustainable agriculture. Heliyon 9:e19487. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e19487","journal-title":"Heliyon"},{"key":"5038_CR58","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s13199-023-00925-9","volume":"90","author":"VK Singh","year":"2023","unstructured":"Singh VK, Kumar A (2023) Secondary metabolites from endophytic fungi: Production, methods of analysis, and diverse pharmaceutical potential. Symbiosis 90:111\u2013125. https:\/\/doi.org\/10.1007\/s13199-023-00925-9","journal-title":"Symbiosis"},{"key":"5038_CR59","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3390\/pathogens10050623","volume":"10","author":"R Soltane","year":"2021","unstructured":"Soltane R, Chrouda A, Mostafa A, Al-Karmalawy AA, Choua\u00efb K, dhahri A, Pashameah RA, Alasiri A, Kutkat O, Shehata M, Jannet HB, Gharbi J, Ali MA (2021) Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate. Pathogens 10:623","journal-title":"Pathogens"},{"key":"5038_CR60","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1016\/0031-9422(90)85173-D","volume":"29","author":"GF Spencer","year":"1990","unstructured":"Spencer GF, Desjardins AE, Plattner RD (1990) 5-(2-Carboxyethyl)-6-Hydroxy-7-Methoxybenzofuran, a Fungal Metabolite of xanthotoxin. Phytochemistry 29:2495\u20132497. https:\/\/doi.org\/10.1016\/0031-9422(90)85173-D","journal-title":"Phytochemistry"},{"key":"5038_CR61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/BF01365707","volume":"57","author":"RD Stipanovic","year":"1975","unstructured":"Stipanovic RD, Schroeder HW (1975) Zearalenol and 8\u2019-hydroxyzearalenone from Fusarium roseum. Mycopathologia 57:77\u201378. https:\/\/doi.org\/10.1007\/BF01365707","journal-title":"Mycopathologia"},{"key":"5038_CR62","doi-asserted-by":"crossref","unstructured":"Strati IF, Kostomitsopoulos G, Lytras F, Zoumpoulakis P, Proestos C, Sinanoglou VJ (2018) Optimization of Polyphenol Extraction from Allium ampeloprasum var. porrum through Response Surface Methodology. Foods 7","DOI":"10.3390\/foods7100162"},{"key":"5038_CR63","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1128\/MMBR.67.4.491-502.2003","volume":"67","author":"G Strobel","year":"2003","unstructured":"Strobel G, Daisy B (2003) Bioprospecting for Microbial Endophytes and Their Natural Products. Microbiol Mol Biol Rev 67:491\u2013502. https:\/\/doi.org\/10.1128\/MMBR.67.4.491-502.2003","journal-title":"Microbiol Mol Biol Rev"},{"key":"5038_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/su14031936","author":"E Tawfik","year":"2022","unstructured":"Tawfik E, Alqurashi M, Aloufi S et al (2022) Characterization of Mutant Aspergillus niger and the Impact on Certain Plants. Sustainability https:\/\/doi.org\/10.3390\/su14031936","journal-title":"Sustainability"},{"key":"5038_CR65","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1021\/np100282k","volume":"73","author":"K Trisuwan","year":"2010","unstructured":"Trisuwan K, Khamthong N, Rukachaisirikul V et al (2010) Anthraquinone, cyclopentanone, and naphthoquinone derivatives from the sea fan-derived fungi Fusarium spp. PSU-F14 and PSU-F135. J Nat Prod 73:1507\u20131511. https:\/\/doi.org\/10.1021\/np100282k","journal-title":"J Nat Prod"},{"key":"5038_CR66","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1021\/acs.analchem.8b05112","volume":"91","author":"J-L Wolfender","year":"2019","unstructured":"Wolfender J-L, Nuzillard J-M, van der Hooft JJJ et al (2019) Accelerating Metabolite Identification in Natural Product Research: Toward an Ideal Combination of Liquid Chromatography-High-Resolution Tandem Mass Spectrometry and NMR Profiling, in Silico Databases, and Chemometrics. Anal Chem 91:704\u2013742. https:\/\/doi.org\/10.1021\/acs.analchem.8b05112","journal-title":"Anal Chem"},{"key":"5038_CR67","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1080\/14786419.2023.2245114","volume":"38","author":"MM Yousef","year":"2024","unstructured":"Yousef MM, Abdelhafez OH, Alsenani F et al (2024) Anti-infective potential of the endophytic fungus Aspergillus sp. associated with Aptenia cordifolia root supported by metabolomics analysis and docking studies. Nat Prod Res 38:3421\u20133426. https:\/\/doi.org\/10.1080\/14786419.2023.2245114","journal-title":"Nat Prod Res"},{"key":"5038_CR68","doi-asserted-by":"publisher","first-page":"e1298","DOI":"10.1002\/wcms.1298","volume":"7","author":"S Yuan","year":"2017","unstructured":"Yuan S, Chan HCS, Hu Z (2017) Using PyMOL as a platform for computational drug design. WIREs Comput Mol Sci 7:e1298. https:\/\/doi.org\/10.1002\/wcms.1298","journal-title":"WIREs Comput Mol Sci"},{"key":"5038_CR69","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1080\/14786410500184157","volume":"20","author":"W Yuan\u2020","year":"2006","unstructured":"Yuan\u2020 W, Zhu\u2020 H, Cheng K et al (2006) A novel butenoate derivative from Aspergillus niger. Nat Prod Res 20:573\u2013577. https:\/\/doi.org\/10.1080\/14786410500184157","journal-title":"Nat Prod Res"},{"issue":"4","key":"5038_CR70","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3892\/br.2016.615","volume":"4","author":"M Zarrin","year":"2016","unstructured":"Zarrin M, Ganj F, Faramarzi S (2016) Analysis of the rDNA internal transcribed spacer region of the Fusarium species by polymerase chain reaction-restriction fragment length polymorphism. Biomedical Rep 4(4):471\u2013474. https:\/\/doi.org\/10.3892\/br.2016.615","journal-title":"Biomedical Rep"},{"key":"5038_CR71","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/md7020097","volume":"7","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Mu J, Feng Y et al (2009) Broad-spectrum antimicrobial epiphytic and endophytic fungi from marine organisms: isolation, bioassay and taxonomy. Mar Drugs 7:97\u2013112. https:\/\/doi.org\/10.3390\/md7020097","journal-title":"Mar Drugs"},{"key":"5038_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.fct.2006.07.030","volume":"45","author":"A Zinedine","year":"2007","unstructured":"Zinedine A, Soriano JM, Molt\u00f3 JC, Ma\u00f1es J (2007) Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Food Chem Toxicol 45:1\u201318","journal-title":"Food Chem Toxicol"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05038-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05038-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05038-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:59:28Z","timestamp":1787986768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-026-05038-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["5038"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-05038-7","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"9 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"600"}}