{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:32:53Z","timestamp":1792992773835,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00203-026-05116-w","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:43:43Z","timestamp":1786344223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Streptomyces griseoincarnatus AR2 from the cold desert as a biofactory for secondary metabolites with multifaceted bioactivities, confirmed by in vitro and in silico approaches"],"prefix":"10.1007","volume":"208","author":[{"given":"Arisha Rameen","family":"Bhatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-6806","authenticated-orcid":false,"given":"Noor","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazrat","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"ul Huda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Tawab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambreen","family":"Latif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra Latif","family":"Ghuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Umar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Rafaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Rafiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"5116_CR1","doi-asserted-by":"publisher","first-page":"6817502","DOI":"10.1155\/2016\/6817502","volume":"2016","author":"M Abu Saleh","year":"2016","unstructured":"Abu Saleh M, Solayman M, Hoque MM, Khan MA, Sarwar MG, Halim MA (2016) Inhibition of DNA topoisomerase type II\u03b1 (TOP2A) by mitoxantrone and its halogenated derivatives: a combined density functional and molecular docking study. Biomed Res Int 2016:6817502. https:\/\/doi.org\/10.1155\/2016\/6817502","journal-title":"Biomed Res Int"},{"key":"5116_CR2","doi-asserted-by":"publisher","DOI":"10.22058\/JPMB.2021.140046.1218","author":"FK Akhar","year":"2021","unstructured":"Akhar FK, Fakhrfeshani M, Alipour H, Ameri MA (2021) Micro algal pigments: an introduction to their biosynthesis, applications and genetic engineering. J Plant Mol Breed. https:\/\/doi.org\/10.22058\/JPMB.2021.140046.1218","journal-title":"J Plant Mol Breed"},{"key":"5116_CR3","doi-asserted-by":"publisher","first-page":"968053","DOI":"10.3389\/fmicb.2022.968053","volume":"13","author":"K Alam","year":"2022","unstructured":"Alam K, Mazumder A, Sikdar S, Zhao Y, Hao J, Song C, Wang Y, Sarkar R, Islam S, Zhang Y, Li A (2022) Streptomyces: the biofactory of secondary metabolites. Front Microbiol 13:968053. https:\/\/doi.org\/10.3389\/fmicb.2022.968053","journal-title":"Front Microbiol"},{"issue":"5","key":"5116_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.resmic.2010.03.011","volume":"161","author":"K Alapati","year":"2010","unstructured":"Alapati K, Peddikotla P, Muvva V, Venkateswarlu Y (2010) Purification and biological evaluation of the metabolites produced by Streptomyces sp. TK-VL_333. Res Microbiol 161(5):335\u2013345. https:\/\/doi.org\/10.1016\/j.resmic.2010.03.011","journal-title":"Res Microbiol"},{"issue":"1","key":"5116_CR5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jcc.21600","volume":"32","author":"AR Allouche","year":"2011","unstructured":"Allouche AR (2011) Gabedit\u2013a graphical user interface for computational chemistry softwares. J Comput Chem 32(1):174\u2013182. https:\/\/doi.org\/10.1002\/jcc.21600","journal-title":"J Comput Chem"},{"issue":"3","key":"5116_CR6","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1099\/00207713-51-3-797","volume":"51","author":"AS Anderson","year":"2001","unstructured":"Anderson AS, Wellington EM (2001) The taxonomy of Streptomyces and related genera. Int J Syst Evol Microbiol 51(3):797\u2013814. https:\/\/doi.org\/10.1099\/00207713-51-3-797","journal-title":"Int J Syst Evol Microbiol"},{"key":"5116_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ab.2019.02.006","volume":"572","author":"P Arulmozhi","year":"2019","unstructured":"Arulmozhi P, Vijayakumar S, Praseetha PK, Jayanthi S (2019) Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem 572:33\u201344. https:\/\/doi.org\/10.1016\/j.ab.2019.02.006","journal-title":"Anal Biochem"},{"issue":"7","key":"5116_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11274-025-04379-7","volume":"41","author":"R Asah-Asante","year":"2025","unstructured":"Asah-Asante R, Tang L, Gong X, Fan S, Yan C, Asante JO, Zeng Q (2025) Exploring pigment-producing Streptomyces as an alternative source to synthetic pigments: diversity, biosynthesis, and biotechnological applications. A review. World J Microbiol Biotechnol 41(7):211. https:\/\/doi.org\/10.1007\/s11274-025-04379-7","journal-title":"World J Microbiol Biotechnol"},{"key":"5116_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jpha.2015.11.005","volume":"6","author":"M Balouiri","year":"2015","unstructured":"Balouiri M, Sadiki M, Saad I (2015) Methods for in vitro evaluating antimicrobial activity: a review. J Pharm Anal 6:71\u201379. https:\/\/doi.org\/10.1016\/j.jpha.2015.11.005","journal-title":"J Pharm Anal"},{"issue":"7","key":"5116_CR12","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1007\/s00203-021-02437-w","volume":"203","author":"S Bayram","year":"2021","unstructured":"Bayram S (2021) Production, purification, and characterization of Streptomyces sp. strain MPPS2 extracellular pyomelanin pigment. Arch Microbiol 203(7):4419\u20134426. https:\/\/doi.org\/10.1007\/s00203-021-02437-w","journal-title":"Arch Microbiol"},{"issue":"1","key":"5116_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ja.2005.1","volume":"58","author":"J B\u00e9rdy","year":"2005","unstructured":"B\u00e9rdy J (2005) Bioactive microbial metabolites. J Antibiot (Tokyo) 58(1):1\u201326. https:\/\/doi.org\/10.1038\/ja.2005.1","journal-title":"J Antibiot (Tokyo)"},{"issue":"1","key":"5116_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12863-025-01400-8","volume":"27","author":"AR Bhatti","year":"2025","unstructured":"Bhatti AR, Hassan N, Ali H, Huda NU, Rahman HU, Anwar J, Saqib A, Khan M, Umar A (2025) Unveiling complete genome sequence of Streptomyces griseoincarnatus AR2 from Katpana cold desert: the roof of the world surrounded by Karakoram mountain range. BMC Genomic Data 27(1):18. https:\/\/doi.org\/10.1186\/s12863-025-01400-8","journal-title":"BMC Genomic Data"},{"issue":"10","key":"5116_CR14","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1002\/cber.19540871013","volume":"87","author":"H Brockmann","year":"1954","unstructured":"Brockmann H, Schmidt-Kastner G (1954) Resistomycin II Mitteil; XXIV. Mitteil \u00fcber Antibiotica aus Actinomyceten. Chem Ber 87(10):1460\u20131469. https:\/\/doi.org\/10.1002\/cber.19540871013","journal-title":"Chem Ber"},{"issue":"16","key":"5116_CR15","doi-asserted-by":"publisher","first-page":"e8811","DOI":"10.1002\/rcm.8811","volume":"34","author":"F Carnevale Neto","year":"2020","unstructured":"Carnevale Neto F, Guaratini T, Colepicolo P, Gates PJ, Lopes NP (2020) Characteristic product ions of acetylene carotenoids by electrospray and nanospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 34(16):e8811. https:\/\/doi.org\/10.1002\/rcm.8811","journal-title":"Rapid Commun Mass Spectrom"},{"issue":"2","key":"5116_CR16","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.jtice.2011.08.004","volume":"43","author":"FJ Chu","year":"2012","unstructured":"Chu FJ, Lin CW, Wu IYP, Chen CH DH (2012) Hydrolysis of bamboo cellulose and cellulase characteristics by Streptomyces griseoaurantiacus ZQBC691. J Taiwan Inst Chem Eng 43(2):220\u2013225. https:\/\/doi.org\/10.1016\/j.jtice.2011.08.004","journal-title":"J Taiwan Inst Chem Eng"},{"issue":"1","key":"5116_CR17","doi-asserted-by":"publisher","first-page":"16387","DOI":"10.1038\/s41598-023-42015-2","volume":"13","author":"A Da","year":"2023","unstructured":"Da A, Wu-Lu M, Dragelj J, Mroginski MA, Ebrahimi KH (2023) Multi-structural molecular docking (MOD) combined with molecular dynamics reveal the structural requirements of designing broad-spectrum inhibitors of SARS-CoV-2 entry to host cells. Sci Rep 13(1):16387. https:\/\/doi.org\/10.1038\/s41598-023-42015-2","journal-title":"Sci Rep"},{"key":"5116_CR18","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.21.24312363","author":"A Danielsen","year":"2024","unstructured":"Danielsen A, Lim C, Yoon CH, Gran JM, Kacelnik O, Eyre D, Bj\u00f8rnholt J (2024) Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008\u20132018. BMJ Open. https:\/\/doi.org\/10.1101\/2024.08.21.24312363","journal-title":"BMJ Open"},{"key":"5116_CR19","doi-asserted-by":"publisher","unstructured":"Fattouche M, Belaidi S, Abchir O, Al-Shaar W, Younes K, Al-Mogren MM, Chtita S, Soualmia F, Hochlaf M (2024) ANN-QSAR, molecular docking, ADMET predictions, and molecular dynamics studies of isothiazole derivatives to design new and selective inhibitors of HCV polymerase NS5B. Pharm (Basel). https:\/\/doi.org\/10.3390\/ph17121712","DOI":"10.3390\/ph17121712"},{"issue":"8","key":"5116_CR20","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3390\/pr11082248","volume":"11","author":"\u0130 Gulcin","year":"2023","unstructured":"Gulcin \u0130, Alwasel SH (2023) DPPH radical scavenging assay. Processes 11(8):2248. https:\/\/www.mdpi.com\/2227-9717\/11\/8\/2248","journal-title":"Processes"},{"issue":"6","key":"5116_CR21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/jobm.19750150604","volume":"15","author":"I Haupt","year":"1975","unstructured":"Haupt I, W\u00e4hnert U, Pitra C, L\u00f6ber G, Luck G, Eckardt K (1975) Effects of the antibiotic resistomycin on the synthesis of macromolecules. Z Allg Mikrobiol 15(6):411\u2013421. https:\/\/doi.org\/10.1002\/jobm.19750150604","journal-title":"Z Allg Mikrobiol"},{"key":"5116_CR22","unstructured":"Information NCfB (2025) PubChem compound summary for CID 11723026, EpithienamycinB. Retrieved July 17 from https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Epithienamycin-B"},{"issue":"3","key":"5116_CR46","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1017\/S0025315400036389","volume":"77","author":"SW Jeffrey","year":"1997","unstructured":"Jeffrey SW, Mantoura RFC, Wright SW (1997) Phytoplankton pigments in oceanography: guidelines to modern methods. J Mar Biol Assoc U K 77(3):918\u2013918. https:\/\/doi.org\/10.1017\/S0025315400036389","journal-title":"J Mar Biol Assoc U K"},{"key":"5116_CR23","doi-asserted-by":"publisher","first-page":"126858","DOI":"10.1016\/j.micres.2021.126858","volume":"252","author":"N Kamarudheen","year":"2021","unstructured":"Kamarudheen N, Khaparde A, Gopal S, Rao KB (2021) Unraveling a natural protease inhibitor from marine Streptomyces griseoincarnatus HK12 active against Chikungunya virus. Microbiol Res 252:126858. https:\/\/doi.org\/10.1016\/j.micres.2021.126858","journal-title":"Microbiol Res"},{"issue":"3","key":"5116_CR24","doi-asserted-by":"publisher","first-page":"602","DOI":"10.16984\/saufenbilder.1397739","volume":"28","author":"\u0130 Karaka\u015f","year":"2024","unstructured":"Karaka\u015f \u0130, \u00c7ardak S, Hac\u0131o\u011flu Do\u011fru N (2024) Pigment production from bacteria isolated from Whey. Sak Univ J Sci 28(3):602\u2013609. https:\/\/doi.org\/10.16984\/saufenbilder.1397739","journal-title":"Sak Univ J Sci"},{"issue":"1","key":"5116_CR25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40643-015-0052-x","volume":"2","author":"AK Kumar","year":"2015","unstructured":"Kumar AK (2015) UV mutagenesis treatment for improved production of endoglucanase and \u03b2-glucosidase from newly isolated thermotolerant actinomycetes, Streptomyces griseoaurantiacus. Bioresour Bioprocess 2(1):22. https:\/\/doi.org\/10.1186\/s40643-015-0052-x","journal-title":"Bioresour Bioprocess"},{"key":"5116_CR26","doi-asserted-by":"publisher","first-page":"e14909","DOI":"10.7717\/peerj.14909","volume":"11","author":"M Lertcanawanichakul","year":"2023","unstructured":"Lertcanawanichakul M, Sahabuddeen T (2023) Characterization of Streptomyces sp. KB1 and its cultural optimization for bioactive compounds production. PeerJ 11:e14909. https:\/\/doi.org\/10.7717\/peerj.14909","journal-title":"PeerJ"},{"issue":"13","key":"5116_CR27","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1128\/jb.05053-11","volume":"193","author":"F Li","year":"2011","unstructured":"Li F, Jiang P, Zheng H, Wang S, Zhao G, Qin S, Liu Z (2011) Draft genome sequence of the marine bacterium Streptomyces griseoaurantiacus M045, which produces novel manumycin-type antibiotics with a pABA core component. J Bacteriol 193(13):3417\u20133418. https:\/\/doi.org\/10.1128\/jb.05053-11","journal-title":"J Bacteriol"},{"issue":"1","key":"5116_CR28","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1038\/s41598-017-10618-1","volume":"7","author":"S Li","year":"2017","unstructured":"Li S, Fan J, Peng C, Chang Y, Guo L, Hou J, Huang M, Wu B, Zheng J, Lin L, Xiao G, Chen W, Liao G, Guo J, Sun P (2017) New molecular insights into the tyrosyl-tRNA synthase inhibitors: CoMFA, CoMSIA analyses and molecular docking studies. Sci Rep 7(1):11525. https:\/\/doi.org\/10.1038\/s41598-017-10618-1","journal-title":"Sci Rep"},{"key":"5116_CR29","doi-asserted-by":"crossref","unstructured":"Longo F, Attanzio A, Marretta L, Luparello C, Indelicato S, Bongiorno D, Barone G, Tesoriere L, Giardina IC, Abruscato G, Perlotti M, Hornsby LB, Arizza V, Vazzana M, Vizzini A, Martino C, Listro A, Queiroz V, Fabbrizio A, Ciaccio PSF, Cascioferro SM, Di Gaudio F, Mauro M (2025) Bioactive molecules from the invasive blue crab Callinectes sapidus exoskeleton: evaluation of reducing, radical scavenging, and antitumor activities. Mar Drugs 23(1): 45. https:\/\/www.mdpi.com\/1660-3397\/23\/1\/45","DOI":"10.3390\/md23010045"},{"key":"5116_CR30","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.22207\/JPAM.12.4.11","volume":"12","author":"KJ Luti","year":"2018","unstructured":"Luti KJ (2018) Mixture design of experiments for the optimization of carbon source for promoting undecylprodigiosin and actinorhodin production. J Pure Appl Microbiol 12:1783\u20131793. https:\/\/doi.org\/10.22207\/JPAM.12.4.11","journal-title":"J Pure Appl Microbiol"},{"issue":"3","key":"5116_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/cphc.202000818","volume":"22","author":"LF Maia","year":"2021","unstructured":"Maia LF, De Oliveira VE, Edwards HGM, De Oliveira LFC (2021) The diversity of linear conjugated polyenes and colours in nature: Raman spectroscopy as a diagnostic tool. Chem Phys Chem 22(3):231\u2013249. https:\/\/doi.org\/10.1002\/cphc.202000818","journal-title":"Chem Phys Chem"},{"issue":"12","key":"5116_CR32","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.7164\/antibiotics.51.1087","volume":"51","author":"N Matsumoto","year":"1998","unstructured":"Matsumoto N, Momose I, Umekita M, Kinoshita N, Chino M, Iinuma H, Sawa T, Hamada M, Takeuchi T (1998) Diperamycin, a new antimicrobial antibiotic produced by Streptomyces griseoaurantiacus MK393-AF2. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) 51(12):1087\u20131092. https:\/\/doi.org\/10.7164\/antibiotics.51.1087","journal-title":"J Antibiot (Tokyo)"},{"key":"5116_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0014-5793(96)00323-7","volume":"384","author":"NJ Miller","year":"1996","unstructured":"Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-evans CA (1996) Antioxidant activities of carotenes and xanthophylls. FEBS Lett 384:240\u2013242. https:\/\/doi.org\/10.1016\/0014-5793(96)00323-7","journal-title":"FEBS Lett"},{"key":"5116_CR34","doi-asserted-by":"publisher","first-page":"835","DOI":"10.13005\/bpj\/3133","volume":"18","author":"A Milliana","year":"2025","unstructured":"Milliana A, Sari RA, Miranda S, Mutiah R (2025) Evaluation of anticancer activity and mechanism of action of myricetin on HeLa, T47D, and Vero cells: comparative analysis with cisplatin and doxorubicin. Biomed Pharmacol J 18:835\u2013847. https:\/\/doi.org\/10.13005\/bpj\/3133","journal-title":"Biomed Pharmacol J"},{"key":"5116_CR35","doi-asserted-by":"publisher","unstructured":"Mohanasundaram S, Karthikeyan P, Sampath V, Anbazhagan M, Prabhu SV, Khaled JM, Thiruvengadam M (2024) Molecular docking, dynamics simulations, ADMET, and DFT calculations: combined in silico approach to screen natural inhibitors of 3CL and PL proteases of SARS-CoV-2. Cell Microbiol 2024(1): 6647757. https:\/\/doi.org\/10.1155\/2024\/6647757","DOI":"10.1155\/2024\/6647757"},{"key":"5116_CR36","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/j.ejmech.2017.10.055","volume":"143","author":"GY Nadysev","year":"2018","unstructured":"Nadysev GY, Tikhomirov AS, Lin MH, Yang YT, Dezhenkova LG, Chen HY, Kaluzhny DN, Schols D, Shtil AA, Shchekotikhin AE, Chueh PJ (2018) Aminomethylation of heliomycin: preparation and anticancer characterization of the first series of semi-synthetic derivatives. Eur J Med Chem 143:1553\u20131562. https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.055","journal-title":"Eur J Med Chem"},{"key":"5116_CR72","doi-asserted-by":"publisher","unstructured":"Naisi S, Bayat M, Salehi TZ, Zarif BR, Yahyaraeyat R (2023) Antimicrobial and anti-biofilm effects of carotenoid pigment extracted from Rhodotorula glutinis strain on food-borne bacteria. Iranian J Microbiol 15(1): 79\u201388. https:\/\/doi.org\/10.18502\/ijm.v15i1.11922","DOI":"10.18502\/ijm.v15i1.11922"},{"key":"5116_CR37","doi-asserted-by":"publisher","unstructured":"Ntim O, Awere-Duodu A, Osman AH, Donkor E (2025) Antimicrobial resistance of bacterial pathogens isolated from cancer patients: a systematic review and meta-analysis. BMC Infect Dis. https:\/\/doi.org\/10.1186\/s12879-025-10481-w","DOI":"10.1186\/s12879-025-10481-w"},{"key":"5116_CR38","unstructured":"Palanichamy V, Hundet A, Mitra B, Reddy NR (2011) Optimization of cultivation parameters for growth and pigment production by streptomyces spp. Isolated from marine sediment and rhizosphere soil. Int J Plant Anim Environ Sci"},{"key":"5116_CR39","doi-asserted-by":"publisher","unstructured":"Pisano MB, Kumar A, Medda R, Gatto G, Pal R, Fais A, Era B, Cosentino S, Uriarte E, Santana L, Pintus F, Matos MJ (2019) Antibacterial activity and molecular docking studies of a selected series of hydroxy-3-arylcoumarins. Molecules. https:\/\/doi.org\/10.3390\/molecules24152815","DOI":"10.3390\/molecules24152815"},{"key":"5116_CR40","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1590\/S1516-89132015060271","volume":"58","author":"K Prashanthi","year":"2015","unstructured":"Prashanthi K, Suryan S, Varalakshmi KN (2015) In vitro anticancer property of yellow pigment from Streptomyces griseoaurantiacus JUACT 01. Braz Arch Biol Technol 58:928\u2013937. https:\/\/doi.org\/10.1590\/S1516-89132015060271","journal-title":"Braz Arch Biol Technol"},{"issue":"1","key":"5116_CR41","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1128\/am.6.1.52-79.1958","volume":"6","author":"TG Pridham","year":"1958","unstructured":"Pridham TG, Hesseltine CW, Benedict RG (1958) A guide for the classification of streptomycetes according to selected groups; placement of strains in morphological sections. Appl Microbiol 6(1):52\u201379. https:\/\/doi.org\/10.1128\/am.6.1.52-79.1958","journal-title":"Appl Microbiol"},{"issue":"1","key":"5116_CR42","first-page":"14","volume":"13","author":"M Rahman","year":"2010","unstructured":"Rahman M, Islam M, Khondkar P, Islam MAU (2010) Characterization and antimicrobial activities of a polypeptide antibiotic isolated from a new strain of Streptomyces parvulus. Bangladesh Pharm J 13(1):14\u201316","journal-title":"Bangladesh Pharm J"},{"issue":"6","key":"5116_CR43","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1021\/ci6004299","volume":"47","author":"SN Rao","year":"2007","unstructured":"Rao SN, Head MS, Kulkarni A, LaLonde JM (2007) Validation studies of the site-directed docking program LibDock. J Chem Inf Model 47(6):2159\u20132171. https:\/\/doi.org\/10.1021\/ci6004299","journal-title":"J Chem Inf Model"},{"key":"5116_CR10","unstructured":"RCSB Protein Data Bank (2024) Structure of type IIA topoisomerase DNA cleavage-religation center (PDB ID: 8KE7). https:\/\/www.rcsb.org\/structure\/8KE7"},{"key":"5116_CR44","doi-asserted-by":"publisher","DOI":"10.36721\/PJPS.0000.00.0.SUP.000-000.1","author":"A Riaz","year":"2020","unstructured":"Riaz A, Rasul A, Hussain G, Saadullah M, Rasool B, Sarfraz I, Masood M, Asrar M, Jabeen F, Sultana T (2020) Resistomycin, a pentacyclic polyketide, inhibits the growth of triple negative breast cancer cells through induction of apoptosis and mitochondrial dysfunction. Pak J pharm sci. https:\/\/doi.org\/10.36721\/PJPS.0000.00.0.SUP.000-000.1","journal-title":"Pak J pharm sci"},{"issue":"2","key":"5116_CR45","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7164\/antibiotics.47.136","volume":"47","author":"BE Roggo","year":"1994","unstructured":"Roggo BE, Petersen F, Delmendo R, Jenny HB, Peter HH, Roesel J (1994) 3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. J Antibiot (Tokyo) 47(2):136\u2013142. https:\/\/doi.org\/10.7164\/antibiotics.47.136","journal-title":"J Antibiot (Tokyo)"},{"issue":"5","key":"5116_CR47","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/14786419.2010.534993","volume":"25","author":"I Sajid","year":"2011","unstructured":"Sajid I, Shaaban KA, Hasnain S (2011) Antitumour compounds from a saline soil isolate, Streptomyces griseoincarnatus CTF15. Nat Prod Res 25(5):549\u2013559. https:\/\/doi.org\/10.1080\/14786419.2010.534993","journal-title":"Nat Prod Res"},{"issue":"2","key":"5116_CR48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s40203-024-00240-1","volume":"12","author":"K Saritha","year":"2024","unstructured":"Saritha K, Alivelu M, Mohammad M (2024) Drug-likeness analysis, in silico ADMET profiling of compounds in Kedrostis foetidissima (Jacq.) Cogn, and antibacterial activity of the plant extract. Silico Pharmacol 12(2):67. https:\/\/doi.org\/10.1007\/s40203-024-00240-1","journal-title":"Silico Pharmacol"},{"key":"5116_CR49","doi-asserted-by":"crossref","unstructured":"Sarmiento-Tovar AA, Silva L, S\u00e1nchez-Su\u00e1rez J, Diaz L (2022) Streptomyces-derived bioactive pigments: ecofriendly source of bioactive compounds. Coatings 12(12): 1858. https:\/\/www.mdpi.com\/2079-6412\/12\/12\/1858","DOI":"10.3390\/coatings12121858"},{"issue":"3","key":"5116_CR50","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/jam.14386","volume":"128","author":"AM Sayed","year":"2020","unstructured":"Sayed AM, Hassan MHA, Alhadrami HA, Hassan HM, Goodfellow M, Rateb ME (2020) Extreme environments: microbiology leading to specialized metabolites. J Appl Microbiol 128(3):630\u2013657. https:\/\/doi.org\/10.1111\/jam.14386","journal-title":"Appl Microbiol"},{"key":"5116_CR51","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1728-1_100","volume-title":"Methods in actinobacteriology. Springer Protocols Handbooks","author":"L Sebastian","year":"2022","unstructured":"Sebastian L, Paul AM, Jayanthi DSK (2022) Isolation and production of prodigiosin pigments from Streptomyces spp. In: Dharumadurai D (ed) Methods in actinobacteriology. Springer Protocols Handbooks. Humana, New York. https:\/\/doi.org\/10.1007\/978-1-0716-1728-1_100"},{"issue":"5","key":"5116_CR52","doi-asserted-by":"publisher","first-page":"499","DOI":"10.4103\/0250-474x.58174","volume":"71","author":"L Selvameenal","year":"2009","unstructured":"Selvameenal L, Radhakrishnan M, Balagurunathan R (2009) Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening. Indian J Pharm Sci 71(5):499\u2013504. https:\/\/doi.org\/10.4103\/0250-474x.58174","journal-title":"Indian J Pharm Sci"},{"key":"5116_CR53","doi-asserted-by":"publisher","first-page":"8","DOI":"10.31632\/ijalsr.2019v02i04.002","volume":"2","author":"S Sen","year":"2019","unstructured":"Sen S (2019) The chemistry and biology of lycopene: antioxidant for human health. Int J Adv Life Sci Res 2:8\u201314. https:\/\/doi.org\/10.31632\/ijalsr.2019v02i04.002","journal-title":"Int J Adv Life Sci Res"},{"issue":"9\u201310","key":"5116_CR54","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1515\/znc-2002-9-1028","volume":"57","author":"Y Shiono","year":"2002","unstructured":"Shiono Y, Shiono N, Seo S, Oka S, Yamazaki Y (2002) Effects of polyphenolic anthrone derivatives, resistomycin and hypericin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z Naturforsch C 57(9\u201310):923\u2013929. https:\/\/doi.org\/10.1515\/znc-2002-9-1028","journal-title":"Z Naturforsch C"},{"issue":"3","key":"5116_CR55","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1099\/00207713-16-3-313","volume":"16","author":"EB Shirling","year":"1966","unstructured":"Shirling EB, Gottlieb D (1966) Methods for characterization of Streptomyces species. Int J Syst Evol Microbiol 16(3):313\u2013340. https:\/\/doi.org\/10.1099\/00207713-16-3-313","journal-title":"Int J Syst Evol Microbiol"},{"key":"5116_CR73","doi-asserted-by":"publisher","unstructured":"Sivakala KK, Guti\u00e9rrez-Garc\u00eda K, Jose PA, Thinesh T, Anandham R, Barona-G\u00f3mez F, Sivakumar N (2021) Desert environments facilitate unique evolution of biosynthetic potential in Streptomyces. Molecules 26(3): 588 https:\/\/doi.org\/10.3390\/molecules26030588","DOI":"10.3390\/molecules26030588"},{"key":"5116_CR57","doi-asserted-by":"publisher","unstructured":"Sivalingam P, Hong K, Pot\u00e9 J, Prabakar K (2019) Extreme environment Streptomyces: potential sources for new antibacterial and anticancer drug leads? Int J Microbiol. https:\/\/doi.org\/10.1155\/2019\/5283948","DOI":"10.1155\/2019\/5283948"},{"issue":"11","key":"5116_CR56","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s00203-024-04169-z","volume":"206","author":"P Sivalingam","year":"2024","unstructured":"Sivalingam P, Easwaran M, Ganapathy D, Basha S, Pot\u00e9 J (2024) Endophytic Streptomyces: an underexplored source with potential for novel natural drug discovery and development. Arch microbiol 206(11):442. https:\/\/doi.org\/10.1007\/s00203-024-04169-z","journal-title":"Arch microbiol"},{"issue":"3","key":"5116_CR58","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1021\/acs.jcim.9b01143","volume":"60","author":"DK Sriramulu","year":"2020","unstructured":"Sriramulu DK, Lee SG (2020) Combinatorial effect of ligand and ligand-binding site hydrophobicities on binding affinity. J Chem Inf Model 60(3):1678\u20131684. https:\/\/doi.org\/10.1021\/acs.jcim.9b01143","journal-title":"J Chem Inf Model"},{"issue":"6","key":"5116_CR59","doi-asserted-by":"publisher","first-page":"628","DOI":"10.7164\/antibiotics.34.628","volume":"34","author":"EO Stapley","year":"1981","unstructured":"Stapley EO, Cassidy PJ, Tunac J, Monaghan RL, Jackson M, Hernandez S, Zimmerman SB, Mata JM, Currie SA, Daoust D, Hendlin D (1981) Epithienamycins-novel beta-lactams related to thienamycin. I. Production and antibacterial activity. J Antibiot (Tokyo) 34(6):628\u2013636. https:\/\/doi.org\/10.7164\/antibiotics.34.628","journal-title":"J Antibiot (Tokyo)"},{"key":"5116_CR60","doi-asserted-by":"publisher","unstructured":"Sugumar M, Karthikeyan P, Venkatesan S, Anbazhagan M, Prabhu SV, Khaled J, Thiruvengadam M (2024) Molecular docking, dynamics simulations, ADMET, and DFT calculations: combined in silico approach to screen natural inhibitors of 3CL and PL proteases of SARS-CoV-2. Cell Microbiol 2024:1\u201319. https:\/\/doi.org\/10.1155\/2024\/6647757","DOI":"10.1155\/2024\/6647757"},{"issue":"3","key":"5116_CR61","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2323\/jgam.49.141","volume":"49","author":"Y Takahashi","year":"2003","unstructured":"Takahashi Y, Omura S (2003) Isolation of new actinomycete strains for the screening of new bioactive compounds. J Gen Appl Microbiol 49(3):141\u2013154. https:\/\/doi.org\/10.2323\/jgam.49.141","journal-title":"J Gen Appl Microbiol"},{"issue":"22","key":"5116_CR62","doi-asserted-by":"publisher","first-page":"e40371","DOI":"10.1016\/j.heliyon.2024.e40371","volume":"10","author":"LP Trenozhnikova","year":"2024","unstructured":"Trenozhnikova LP, Baimakhanova GB, Baimakhanova BB, Balgimbayeva AS, Daugaliyeva ST, Faizulina ER, Tatarkina LG, Spankulova GA, Berillo DA, Beutler JA (2024) Beyond traditional screening: Unveiling antibiotic potentials of actinomycetes in extreme environments. Heliyon 10(22):e40371. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e40371","journal-title":"Heliyon"},{"issue":"15","key":"5116_CR63","doi-asserted-by":"publisher","first-page":"4724","DOI":"10.3390\/molecules27154724","volume":"27","author":"J Udensi","year":"2022","unstructured":"Udensi J, Loskutova E, Loughman J, Byrne HJ (2022) Quantitative Raman analysis of carotenoid protein complexes in aqueous solution. Molecules 27(15):4724. https:\/\/doi.org\/10.3390\/molecules27154724","journal-title":"Molecules"},{"key":"5116_CR65","doi-asserted-by":"publisher","first-page":"112748","DOI":"10.1016\/j.indcrop.2020.112748","volume":"154","author":"V Vanitha","year":"2020","unstructured":"Vanitha V, Vijayakumar S, Nilavukkarasi M, Punitha VN, Vidhya E, Praseetha PK (2020) Heneicosane\u2014a novel microbicidal bioactive alkane identified from Plumbago zeylanica L. Ind Crops Prod 154:112748. https:\/\/doi.org\/10.1016\/j.indcrop.2020.112748","journal-title":"Crops Prod"},{"key":"5116_CR66","doi-asserted-by":"publisher","first-page":"101393","DOI":"10.1016\/j.genrep.2021.101393","volume":"25","author":"V Vanitha","year":"2021","unstructured":"Vanitha V, Vijayakumar S, Prabhu S, Nilavukkarasi M, Punitha VN, Vidhya E, Praseetha PK (2021) In vitro and in silico protocols for the assessment of microbicidal compounds from Plumbago zeylanica L. Gene Rep 25:101393. https:\/\/doi.org\/10.1016\/j.genrep.2021.101393","journal-title":"Gene Rep"},{"key":"5116_CR67","doi-asserted-by":"publisher","first-page":"100688","DOI":"10.1016\/j.genrep.2020.100688","volume":"20","author":"E Vidhya","year":"2020","unstructured":"Vidhya E, Vijayakumar S, Prathipkumar S, Praseetha PK (2020) Green way biosynthesis: characterization, antimicrobial and anticancer activity of ZnO nanoparticles. Gene Rep 20:100688. https:\/\/doi.org\/10.1016\/j.genrep.2020.100688","journal-title":"Gene Rep"},{"issue":"6","key":"5116_CR64","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1007\/s12275-011-1260-5","volume":"49","author":"R Vijayabharathi","year":"2011","unstructured":"Vijayabharathi R, Bruheim P, Andreassen T, Raja DS, Devi PB, Sathyabama S, Priyadarisini VB (2011) Assessment of resistomycin, as an anticancer compound isolated and characterized from Streptomyces aurantiacus AAA. 5 J Microbiol 49(6):920\u2013926. https:\/\/doi.org\/10.1007\/s12275-011-1260-5","journal-title":"5 J Microbiol"},{"issue":"3","key":"5116_CR68","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1128\/aac.02067-12","volume":"57","author":"AG Warrilow","year":"2013","unstructured":"Warrilow AG, Parker JE, Kelly DE, Kelly SL (2013) Azole affinity of sterol 14\u03b1-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother 57(3):1352\u20131360. https:\/\/doi.org\/10.1128\/aac.02067-12","journal-title":"Antimicrob Agents Chemother"},{"key":"5116_CR69","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cplett.2016.04.085","volume":"653","author":"R West","year":"2016","unstructured":"West R, Ke\u015fan G, Trskov\u00e1 E, Sobotka R, Ka\u0148a R, Fuciman M, Pol\u00edvka T (2016) Spectroscopic properties of the triple bond carotenoid alloxanthin. Chem Phys Lett 653:167\u2013172. https:\/\/doi.org\/10.1016\/j.cplett.2016.04.085","journal-title":"Chem Phys Lett"},{"issue":"7","key":"5116_CR71","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1021\/jf305210u","volume":"61","author":"YL Zhang","year":"2013","unstructured":"Zhang YL, Li S, Jiang DH, Kong LC, Zhang PH, Xu JD (2013) Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02. J Agri Food Chem 61(7):1521\u20131524. https:\/\/doi.org\/10.1021\/jf305210u","journal-title":"J Agri Food Chem"},{"key":"5116_CR70","doi-asserted-by":"publisher","first-page":"115960","DOI":"10.1016\/j.ecoenv.2024.115960","volume":"271","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Luo C, Li Z, Huang W, Zheng S, Liu C, Shi X, Ma Y, Ni Q, Tan W, Peng J, Chen Y, Wu W, Li J, Wu K (2024) Astaxanthin activates the Nrf2\/Keap1\/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity. Ecotoxicol Environ Saf 271:115960. https:\/\/doi.org\/10.1016\/j.ecoenv.2024.115960","journal-title":"Ecotoxicol Environ Saf"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05116-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05116-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05116-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:35:22Z","timestamp":1792989322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05116-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":73,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["5116"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-05116-w","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"9 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"563"}}