{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:32:52Z","timestamp":1792992772248,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Science and Technology Department of Shaanxi Province","award":["2024SF-YBXM-279"],"award-info":[{"award-number":["2024SF-YBXM-279"]}]},{"name":"the Genertec Medical Scientific Research Fund","award":["TYYLKYJJ-2024-018"],"award-info":[{"award-number":["TYYLKYJJ-2024-018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s00203-026-05145-5","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:02:30Z","timestamp":1787040150000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidrug-resistant livestock-associated ST9-MRSA causing severe human infection without animal exposure: the food chain as a potential transmission route in China"],"prefix":"10.1007","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0173-8130","authenticated-orcid":false,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-1220","authenticated-orcid":false,"given":"Zi-hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0743-9317","authenticated-orcid":false,"given":"Guo-feng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-jiong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"6","key":"5145_CR1","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3390\/toxins5061140","volume":"5","author":"BJ Berube","year":"2013","unstructured":"Berube BJ, Wardenburg JB (2013) \u03b1-Toxin: nearly a century of intrigue. Toxins 5(6):1140\u20131166. https:\/\/doi.org\/10.3390\/toxins5061140","journal-title":"Toxins"},{"issue":"1","key":"5145_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/jac\/dkx357","volume":"73","author":"CJ Chen","year":"2018","unstructured":"Chen CJ, Lauderdale TY, Lu CT, Chuang YY, Yang CC, Wu TS, Lee CY, Lu MC, Ko WC, Huang YC (2018) Clinical and molecular features of MDR livestock-associated MRSA ST9 with staphylococcal cassette chromosome mecXII in humans. J Antimicrob Chemother 73(1):33\u201340. https:\/\/doi.org\/10.1093\/jac\/dkx357","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"5145_CR3","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1093\/jac\/dkad174","volume":"78","author":"Y Chen","year":"2023","unstructured":"Chen Y, Sun L, Hong YQ, Chen MZ, Zhang H, Peng YQ, Liao K, Wang HP, Zhu FT, Zhuang HM, Wang ZG, Jiang SN, Yu YS, Chen Y (2023) Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China. J Antimicrob Chemother 78(8):1871\u20131881. https:\/\/doi.org\/10.1093\/jac\/dkad174","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"5145_CR4","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00282-25","volume":"10","author":"Y Chen","year":"2025","unstructured":"Chen Y, Zhu F, Hong Y, Liu Y, Wang H, Jiang S, Chen M, Ji S, Wang Z, Yu Y, Chen Y, Sun L (2025) Characterization of the virulence shaping and adaptability in the methicillin-resistant Staphylococcus aureus ST9 lineage. mSystems 10(7):e0028225. https:\/\/doi.org\/10.1128\/msystems.00282-25","journal-title":"mSystems"},{"issue":"4","key":"5145_CR5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.ijantimicag.2014.12.007","volume":"45","author":"YY Chuang","year":"2015","unstructured":"Chuang YY, Huang YC (2015) Livestock-associated meticillin-resistant Staphylococcus aureus in Asia: an emerging issue? Int J Antimicrob Agents 45(4):334\u2013340. https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.12.007","journal-title":"Int J Antimicrob Agents"},{"key":"5145_CR6","volume-title":"Performance standards for antimicrobial susceptibility testing M100. CLSI document M100","author":"CLSI","year":"2023","unstructured":"CLSI (2023) Performance standards for antimicrobial susceptibility testing M100. CLSI document M100. CLSI, Wayne, PA"},{"key":"5145_CR7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3390\/antibiotics4040521","volume":"4","author":"C Cuny","year":"2015","unstructured":"Cuny C, Wieler LH, Witte W (2015) Livestock-associated MRSA: the impact on humans. Antibiotics 4:521\u2013543. https:\/\/doi.org\/10.3390\/antibiotics4040521","journal-title":"Antibiotics"},{"key":"5145_CR8","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/j.1439-0450.1972.tb00439.x","volume":"19","author":"LA Devriese","year":"1972","unstructured":"Devriese LA, Van Damme LR, Fameree L (1972) Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases. Zentralbl Veterinarmed B 19:598\u2013605. https:\/\/doi.org\/10.1111\/j.1439-0450.1972.tb00439.x","journal-title":"Zentralbl Veterinarmed B"},{"issue":"14","key":"5145_CR9","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1017\/S0950268815000126","volume":"143","author":"V Dhup","year":"2015","unstructured":"Dhup V, Kearns AM, Pichon B, Foster HA (2015) First report of identification of livestock associated MRSA ST9 in retail meat in England. Epidemiol Infect 143(14):2989\u20132992. https:\/\/doi.org\/10.1017\/S0950268815000126","journal-title":"Epidemiol Infect"},{"issue":"1","key":"5145_CR10","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1080\/22221751.2020.1848354","volume":"9","author":"Y Jin","year":"2020","unstructured":"Jin Y, Yu X, Chen Y, Chen W, Shen P, Luo Q, Zhang S, Kong X, Zheng B, Xiao Y (2020) Characterization of highly virulent community-associated methicillin-resistant Staphylococcus aureus ST9-SCCmec XII causing bloodstream infection in China. Emerg Microbes Infect 9(1):2526\u20132535. https:\/\/doi.org\/10.1080\/22221751.2020.1848354","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"5145_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1080\/22221751.2022.2027218","volume":"11","author":"Y Jin","year":"2022","unstructured":"Jin Y, Zhou W, Zhan Q, Chen Y, Luo Q, Shen P, Xiao Y (2022) Genomic epidemiology and characterisation of penicillin-sensitive Staphylococcus aureus isolates from invasive bloodstream infections in China: an increasing prevalence and higher diversity in genetic typing be revealed. Emerg Microbes Infect 11(1):326\u2013336. https:\/\/doi.org\/10.1080\/22221751.2022.2027218","journal-title":"Emerg Microbes Infect"},{"issue":"9","key":"5145_CR12","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.5455\/OVJ.2024.v14.i9.1","volume":"14","author":"AR Khairullah","year":"2024","unstructured":"Khairullah AR, Widodo A, Riwu KHP, Yanestria SM, Moses IB, Effendi MH, Fauzia KA, Fauziah I, Hasib A, Kusala MKJ, Raissa R, Silaen OSM, Ramandinianto SC, Afnani DA (2024) Spread of livestock-associated methicillin-resistant Staphylococcus aureus in poultry and its risks to public health: a comprehensive review. Open Vet J 14(9):2116\u20132128. https:\/\/doi.org\/10.5455\/OVJ.2024.v14.i9.1","journal-title":"Open Vet J"},{"issue":"4","key":"5145_CR13","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00020-18","volume":"31","author":"S Lakhundi","year":"2018","unstructured":"Lakhundi S, Zhang K (2018) Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Rev 31(4):e00020-18. https:\/\/doi.org\/10.1128\/CMR.00020-18","journal-title":"Clin Microbiol Rev"},{"key":"5145_CR14","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s41579-024-01054-w","volume":"22","author":"WR Miller","year":"2024","unstructured":"Miller WR, Arias CA (2024) ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics. Nat Rev Microbiol 22:598\u2013616. https:\/\/doi.org\/10.1038\/s41579-024-01054-w","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"5145_CR15","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1017\/S0950268810000075","volume":"138","author":"MN Mulders","year":"2010","unstructured":"Mulders MN, Haenen AP, Geenen PL, Vesseur PC, Poldervaart ES, Bosch T, Huijsdens XW, Hengeveld PD, Dam-Deisz WD, Graat EA, Mevius D, Voss A, Van De Giessen AW (2010) Prevalence of livestock-associated MRSA in broiler flocks and risk factors for slaughterhouse personnel in The Netherlands. Epidemiol Infect 138(5):743\u2013755. https:\/\/doi.org\/10.1017\/S0950268810000075","journal-title":"Epidemiol Infect"},{"key":"5145_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1528408","volume":"15","author":"A Nemati","year":"2025","unstructured":"Nemati A, Gigliucci F, Morabito S, Badouei MA (2025) Virulence plasmids in edema disease: insights from whole-genome analysis of porcine O139:H1 Shiga toxin-producing Escherichia coli (STEC) strains. Front Cell Infect Microbiol 15:1528408. https:\/\/doi.org\/10.3389\/fcimb.2025.1528408","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"5145_CR17","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001245","volume":"168","author":"AC Silva-de-Jesus","year":"2022","unstructured":"Silva-de-Jesus AC, Ferrari RG, Panzenhagen P, Conte-Junior CA (2022) Staphylococcus aureus biofilm: the role in disseminating antimicrobial resistance over the meat chain. Microbiol 168(10):10.1099\/mic.0.001245. https:\/\/doi.org\/10.1099\/mic.0.001245","journal-title":"Microbiol"},{"key":"5145_CR18","unstructured":"The State Council of the People\u2019s Republic of China (2019), July 15 Opinions of the State Council on implementing the Healthy China initiative (State Council Document No. 13 [2019]). https:\/\/www.gov.cn\/zhengce\/content\/2019-07\/15\/content_5409492.htm"},{"key":"5145_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","volume":"17","author":"NA Turner","year":"2019","unstructured":"Turner NA, Sharma-Kuinkel BK, Maskarinec SA, Eichenberger EM, Shah PP, Carugati M, Holland TL, Fowler VG (2019) Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research. Nat Rev Microbiol 17:203\u2013218. https:\/\/doi.org\/10.1038\/s41579-018-0147-4","journal-title":"Nat Rev Microbiol"},{"issue":"12","key":"5145_CR20","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3201\/eid1112.050428","volume":"11","author":"A Voss","year":"2005","unstructured":"Voss A, Loeffen F, Bakker J, Klaassen C, Wulf M (2005) Methicillin-resistant Staphylococcus aureus in pig farming. Emerg Infect Dis 11(12):1965\u20131966. https:\/\/doi.org\/10.3201\/eid1112.050428","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"5145_CR21","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1128\/JB.188.4.1310-1315.2006","volume":"188","author":"WJ van Wamel","year":"2006","unstructured":"van Wamel WJ, Rooijakkers SH, Ruyken M, van Kessel KP, van Strijp JA (2006) The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages. J Bacteriol 188(4):1310\u20131315. https:\/\/doi.org\/10.1128\/JB.188.4.1310-1315.2006","journal-title":"J Bacteriol"},{"issue":"37","key":"5145_CR22","doi-asserted-by":"publisher","first-page":"86521","DOI":"10.1007\/s11356-023-28532-7","volume":"30","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhang P, Wu J, Chen S, Jin Y, Long J, Duan G, Yang H (2023) Transmission of livestock-associated methicillin-resistant Staphylococcus aureus between animals, environment, and humans in the farm. Environ Sci Pollut Res Int 30(37):86521\u201386539. https:\/\/doi.org\/10.1007\/s11356-023-28532-7","journal-title":"Environ Sci Pollut Res Int"},{"key":"5145_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1392134","volume":"15","author":"W Zhang","year":"2024","unstructured":"Zhang W, Wang X, Zhao L, Gu Y, Chen Y, Liu N, An L, Bai L, Chen Y, Cui S (2024) Genome-based surveillance reveals cross-transmission of MRSA ST59 between humans and retail livestock products in Hanzhong, China. Front Microbiol 15:1392134. https:\/\/doi.org\/10.3389\/fmicb.2024.1392134","journal-title":"Front Microbiol"},{"issue":"1","key":"5145_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3390\/ijms25010395","volume":"25","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Hu Z, Li S, Fang R, Ono HK, Hu DL (2023) Molecular characteristics and pathogenicity of Staphylococcus aureus exotoxins. Int J Mol Sci 25(1):395. https:\/\/doi.org\/10.3390\/ijms25010395","journal-title":"Int J Mol Sci"},{"issue":"4","key":"5145_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103388","volume":"9","author":"G Zou","year":"2022","unstructured":"Zou G, Matuszewska M, Jia M, Zhou J, Ba X, Duan J, Zhang C, Zhao J et al (2022) A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal methicillin-resistant Staphylococcus aureus populations. Adv Sci 9(4):e2103388. https:\/\/doi.org\/10.1002\/advs.202103388","journal-title":"Adv Sci"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05145-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05145-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05145-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:35:16Z","timestamp":1792989316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05145-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["5145"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-05145-5","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,18]]},"assertion":[{"value":"15 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"584"}}