{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:10:36Z","timestamp":1788682236201,"version":"build-2803163510"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No.: 32572911"],"award-info":[{"award-number":["Grant No.: 32572911"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["Grant No.: LH2024C096"],"award-info":[{"award-number":["Grant No.: LH2024C096"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Microbiol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00203-026-05170-4","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:58:16Z","timestamp":1788681496000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b3-Butyrolactones and \u03b3-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces"],"prefix":"10.1007","volume":"208","author":[{"given":"Linyao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-2494","authenticated-orcid":false,"given":"Chunmei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"8","key":"5170_CR1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ja.2012.27","volume":"65","author":"J B\u00e9rdy","year":"2012","unstructured":"B\u00e9rdy J (2012) Thoughts and facts about antibiotics: where we are now and where we are heading. J Antibiot 65(8):385\u2013395. https:\/\/doi.org\/10.1038\/ja.2012.27","journal-title":"J Antibiot"},{"issue":"1","key":"5170_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/S12863-025-01400-8","volume":"27","author":"AR Bhatti","year":"2025","unstructured":"Bhatti AR, Hassan N, Ali H et al (2025) Unveiling complete genome sequence of Streptomyces griseoincarnatus AR2 from Katpana cold desert: the roof of the world surrounded by Karakoram mountain range. BMC Genom Data 27(1):18\u201318. https:\/\/doi.org\/10.1186\/S12863-025-01400-8","journal-title":"BMC Genom Data"},{"key":"5170_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cbpa.2015.06.024","volume":"28","author":"M Biarnes-Carrera","year":"2015","unstructured":"Biarnes-Carrera M, Breitling R, Takano E et al (2015) Butyrolactone signalling circuits for synthetic biology. Curr Opin Chem Biol 28:91\u201398. https:\/\/doi.org\/10.1016\/j.cbpa.2015.06.024","journal-title":"Curr Opin Chem Biol"},{"key":"5170_CR4","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1039\/c39870000402","volume":"6","author":"GT Carter","year":"1987","unstructured":"Carter GT, Nietsche JA, Borders DB (1987) Structure determination of LL-F28249\u03b1, \u03b2, \u03b3, and \u03bb, potent antiparasitic macrolides from Streptomyces cyaneogriseus ssp. noncyanogenus. J Chem Soc Chem Commun 6:402\u2013404. https:\/\/doi.org\/10.1039\/c39870000402","journal-title":"J Chem Soc Chem Commun"},{"issue":"7","key":"5170_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021974","volume":"6","author":"A Chatterjee","year":"2011","unstructured":"Chatterjee A, Drews L, Mehra S et al (2011) Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis. PLoS One 6(7):e21974. https:\/\/doi.org\/10.1371\/journal.pone.0021974","journal-title":"PLoS One"},{"issue":"2","key":"5170_CR6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00253-008-1545-8","volume":"80","author":"L Chen","year":"2008","unstructured":"Chen L, Lu Y, Chen J et al (2008) Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Appl Microbiol Biotechnol 80(2):277\u2013286. https:\/\/doi.org\/10.1007\/s00253-008-1545-8","journal-title":"Appl Microbiol Biotechnol"},{"issue":"12","key":"5170_CR7","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.13461\/j.cnki.cja.006952","volume":"45","author":"R Chen","year":"2020","unstructured":"Chen R, Liang D, Liu J et al (2020) Advances in the regulation of Streptomyces silent biosynthetic gene clusters. Chin J Antibiot 45(12):1201\u20131207. https:\/\/doi.org\/10.13461\/j.cnki.cja.006952","journal-title":"Chin J Antibiot"},{"issue":"1","key":"5170_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/S00253-024-13396-9","volume":"109","author":"H Chen","year":"2025","unstructured":"Chen H, Liu X, Wei B et al (2025) Identification of a novel butenolide signal system to regulate high production of tylosin in Streptomyces fradiae. Appl Microbiol Biotechnol 109(1):18. https:\/\/doi.org\/10.1007\/S00253-024-13396-9","journal-title":"Appl Microbiol Biotechnol"},{"issue":"6","key":"5170_CR9","doi-asserted-by":"publisher","first-page":"960","DOI":"10.16476\/j.pibb.2021.0168","volume":"49","author":"K Cheng","year":"2022","unstructured":"Cheng K, Zeng Y, Cai Z et al (2022) The communication signal of microorganisms. Prog Biochem Biophys 49(6):960\u2013974. https:\/\/doi.org\/10.16476\/j.pibb.2021.0168","journal-title":"Prog Biochem Biophys"},{"issue":"45","key":"5170_CR10","doi-asserted-by":"publisher","first-page":"17510","DOI":"10.1073\/pnas.0805530105","volume":"105","author":"C Corre","year":"2008","unstructured":"Corre C, Song L, O\u2019Rourke S et al (2008) 2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc Natl Acad Sci U S A 105(45):17510\u201317515. https:\/\/doi.org\/10.1073\/pnas.0805530105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5170_CR11","doi-asserted-by":"publisher","DOI":"10.1039\/D5NP00069F","author":"WJP Cunliffe","year":"2026","unstructured":"Cunliffe WJP, Rutledge PJ (2026) New secondary metabolites isolated from Streptomyces species. Nat Prod Rep. https:\/\/doi.org\/10.1039\/D5NP00069F","journal-title":"Nat Prod Rep"},{"issue":"3","key":"5170_CR12","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1128\/MMBR.00018-13","volume":"77","author":"L Cuthbertson","year":"2013","unstructured":"Cuthbertson L, Nodwell JR (2013) The TetR family of regulators. Microbiol Mol Biol Rev 77(3):440\u2013475. https:\/\/doi.org\/10.1128\/MMBR.00018-13","journal-title":"Microbiol Mol Biol Rev"},{"issue":"14","key":"5170_CR13","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1021\/ol9009893","volume":"11","author":"JB Davis","year":"2009","unstructured":"Davis JB, Bailey JD, Sello JK et al (2009) Biomimetic synthesis of a new class of bacterial signaling molecules. Org Lett 11(14):2984\u20132987. https:\/\/doi.org\/10.1021\/ol9009893","journal-title":"Org Lett"},{"key":"5170_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00349","volume":"8","author":"G Devescovi","year":"2017","unstructured":"Devescovi G, Kojic M, Covaceuszach S et al (2017) Negative regulation of violacein biosynthesis in Chromobacterium violaceum. Front Microbiol 8:349. https:\/\/doi.org\/10.3389\/fmicb.2017.00349","journal-title":"Front Microbiol"},{"issue":"3","key":"5170_CR15","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3390\/MICROBIOLRES13030031","volume":"13","author":"L Donald","year":"2022","unstructured":"Donald L, Pipite A, Subramani R et al (2022) Streptomyces: still the biggest producer of new natural secondary metabolites, a current perspective. Microbiol Res 13(3):418\u2013465. https:\/\/doi.org\/10.3390\/MICROBIOLRES13030031","journal-title":"Microbiol Res"},{"issue":"23","key":"5170_CR16","doi-asserted-by":"publisher","first-page":"8415","DOI":"10.1128\/AEM.05898-11","volume":"77","author":"Y Du","year":"2011","unstructured":"Du Y, Shen X, Yu P et al (2011) Gamma-butyrolactone regulatory system of Streptomyces chattanoogensis links nutrient utilization, metabolism, and development. Appl Environ Microbiol 77(23):8415\u20138426. https:\/\/doi.org\/10.1128\/AEM.05898-11","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"5170_CR17","doi-asserted-by":"publisher","first-page":"e202200208","DOI":"10.1002\/cbdv.202200208","volume":"19","author":"H Fan","year":"2022","unstructured":"Fan H, Wei X, Si Tu MX et al (2022) \u03b3-Aromatic butenolides of microbial source\u2013a review of their structures, biological activities and biosynthesis. Chem Biodivers 19(6):e202200208. https:\/\/doi.org\/10.1002\/cbdv.202200208","journal-title":"Chem Biodivers"},{"issue":"1","key":"5170_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/S12934-025-02711-2","volume":"24","author":"J Gang","year":"2025","unstructured":"Gang J, Tian Q, Du C (2025) Effects of Magnaporthe oryzae cell-free filtrate on the secondary metabolism of Streptomyces bikiniensis HD-087: a non-targeted metabolomics analysis. Microb Cell Fact 24(1):90. https:\/\/doi.org\/10.1186\/S12934-025-02711-2","journal-title":"Microb Cell Fact"},{"issue":"5","key":"5170_CR19","doi-asserted-by":"publisher","first-page":"585","DOI":"10.13461\/j.cnki.cja.007902","volume":"50","author":"W Gao","year":"2025","unstructured":"Gao W, Liu X, Li J et al (2025) Regulation and application of the Streptomyces quorum sensing system in antibiotics biosynthesis. Chin J Antibiot 50(5):585\u2013593. https:\/\/doi.org\/10.13461\/j.cnki.cja.007902","journal-title":"Chin J Antibiot"},{"issue":"9","key":"5170_CR20","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1021\/acschembio.7b00458","volume":"12","author":"JP Gerdt","year":"2017","unstructured":"Gerdt JP, Wittenwyler DM, Combs JB et al (2017) Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling. ACS Chem Biol 12(9):2457\u20132464. https:\/\/doi.org\/10.1021\/acschembio.7b00458","journal-title":"ACS Chem Biol"},{"issue":"10","key":"5170_CR21","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.13344\/j.microbiol.china.2013.10.011","volume":"40","author":"X Han","year":"2013","unstructured":"Han X, Shen Y (2013) TetR family proteins in regulation of secondary metabolism in Streptomyces. Microbiol China 40(10):1831\u20131846. https:\/\/doi.org\/10.13344\/j.microbiol.china.2013.10.011","journal-title":"Microbiol China"},{"key":"5170_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.580990","volume":"11","author":"F Handel","year":"2020","unstructured":"Handel F, Kulik A, Mast Y (2020) Investigation of the autoregulator-receptor system in the pristinamycin producer Streptomyces pristinaespiralis. Front Microbiol 11:580990. https:\/\/doi.org\/10.3389\/fmicb.2020.580990","journal-title":"Front Microbiol"},{"issue":"8","key":"5170_CR23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/s41429-025-00840-9","volume":"78","author":"A Hirata","year":"2025","unstructured":"Hirata A, Sumiyoshi M, Fujita H et al (2025) Rare distribution of butenolide-type signaling molecules among Streptomyces strains and functional importance as inducing factors for secondary metabolite production in Streptomyces rochei 7434AN4. J Antibiot 78(8):488\u2013499. https:\/\/doi.org\/10.1038\/s41429-025-00840-9","journal-title":"J Antibiot"},{"issue":"7054","key":"5170_CR24","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/nature03912","volume":"436","author":"LR Hoffman","year":"2005","unstructured":"Hoffman LR, D\u2019Argenio DA, MacCoss MJ et al (2005) Aminoglycoside antibiotics induce bacterial biofilm formation. Nature 436(7054):1171\u20131175. https:\/\/doi.org\/10.1038\/nature03912","journal-title":"Nature"},{"issue":"4","key":"5170_CR25","doi-asserted-by":"publisher","DOI":"10.2741\/horinouc","volume":"7","author":"S Horinouchi","year":"2002","unstructured":"Horinouchi S (2002) A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus. Front Biosci 7(4):A897. https:\/\/doi.org\/10.2741\/horinouc","journal-title":"Front Biosci"},{"issue":"9\u201310","key":"5170_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2183\/pjab.83.277","volume":"83","author":"S Horinouchi","year":"2007","unstructured":"Horinouchi S, Beppu T (2007) Hormonal control by A-factor of morphological development and secondary metabolism in Streptomyces. Proc Jpn Acad Ser B 83(9\u201310):277\u2013295. https:\/\/doi.org\/10.2183\/pjab.83.277","journal-title":"Proc Jpn Acad Ser B"},{"key":"5170_CR27","doi-asserted-by":"publisher","DOI":"10.1177\/1934578x1701200526","author":"SRM Ibrahim","year":"2017","unstructured":"Ibrahim SRM, Mohamed GA, Khedr AIM (2017) \u03b3-Butyrolactones from Aspergillus species: structures, biosynthesis, and biological activities. Nat Prod Commun. https:\/\/doi.org\/10.1177\/1934578x1701200526","journal-title":"Nat Prod Commun"},{"key":"5170_CR28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57824","volume":"9","author":"I Kapoor","year":"2020","unstructured":"Kapoor I, Olivares P, Nair SK (2020) Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones. eLife 9:e57824. https:\/\/doi.org\/10.7554\/eLife.57824","journal-title":"eLife"},{"issue":"7","key":"5170_CR29","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1128\/JB.186.7.2206-2211.2004","volume":"186","author":"J Kato","year":"2004","unstructured":"Kato J, Miyahisa I, Mashiko M et al (2004) A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus. J Bacteriol 186(7):2206\u20132211. https:\/\/doi.org\/10.1128\/JB.186.7.2206-2211.2004","journal-title":"J Bacteriol"},{"issue":"7","key":"5170_CR30","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1073\/pnas.0607472104","volume":"104","author":"J Kato","year":"2007","unstructured":"Kato J, Funa N, Watanabe H et al (2007) Biosynthesis of \u03b3-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces. Proc Natl Acad Sci USA 104(7):2378\u20132383. https:\/\/doi.org\/10.1073\/pnas.0607472104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"5170_CR31","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1046\/j.1365-2958.2000.01819.x","volume":"36","author":"R Kawachi","year":"2000","unstructured":"Kawachi R, Akashi T, Kamitani Y et al (2000) Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance. Mol Microbiol 36(2):302\u2013313. https:\/\/doi.org\/10.1046\/j.1365-2958.2000.01819.x","journal-title":"Mol Microbiol"},{"issue":"21","key":"5170_CR32","doi-asserted-by":"publisher","first-page":"6259","DOI":"10.1128\/JB.182.21.6259-6263.2000","volume":"182","author":"R Kawachi","year":"2000","unstructured":"Kawachi R, Wangchaisoonthorn U, Nihira T et al (2000) Identification by gene deletion analysis of a regulator, VmsR, that controls virginiamycin biosynthesis in Streptomyces virginiae. J Bacteriol 182(21):6259\u20136263. https:\/\/doi.org\/10.1128\/JB.182.21.6259-6263.2000","journal-title":"J Bacteriol"},{"issue":"1","key":"5170_CR33","first-page":"232","volume":"177","author":"AS Khokhlov","year":"1967","unstructured":"Khokhlov AS, Tovarova II, Borisova LN et al (1967) The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini. Doklady Akademii Nauk SSSR Nov-Dec 177(1):232\u2013235","journal-title":"Doklady Akademii Nauk SSSR Nov-Dec"},{"issue":"10","key":"5170_CR34","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1248\/cpb.25.2593","volume":"25","author":"N Kiriyama","year":"1977","unstructured":"Kiriyama N, Nitta K, Sakaguchi Y et al (1977) Studies on the metabolic products of Aspergillus terreus. III. Metabolites of the strain IFO 8835.(1). Chem Pharm Bull (Tokyo) 25(10):2593\u20132601. https:\/\/doi.org\/10.1248\/cpb.25.2593","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"39","key":"5170_CR35","doi-asserted-by":"publisher","first-page":"16410","DOI":"10.1073\/pnas.1113908108","volume":"108","author":"S Kitani","year":"2011","unstructured":"Kitani S, Miyamoto KT, Takamatsu S et al (2011) Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis. Proc Natl Acad Sci USA 108(39):16410\u201316415. https:\/\/doi.org\/10.1073\/pnas.1113908108","journal-title":"Proc Natl Acad Sci USA"},{"key":"5170_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02927","volume":"10","author":"D Kong","year":"2019","unstructured":"Kong D, Wang X, Nie J et al (2019) Regulation of antibiotic production by signaling molecules in Streptomyces. Front Microbiol 10:2927. https:\/\/doi.org\/10.3389\/fmicb.2019.02927","journal-title":"Front Microbiol"},{"issue":"7","key":"5170_CR37","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s41564-023-01382-2","volume":"8","author":"MKC Krespach","year":"2023","unstructured":"Krespach MKC, Stroe MC, Netzker T et al (2023) Streptomyces polyketides mediate bacteria\u2013fungi interactions across soil environments. Nat Microbiol 8(7):1348\u20131361. https:\/\/doi.org\/10.1038\/s41564-023-01382-2","journal-title":"Nat Microbiol"},{"issue":"4","key":"5170_CR38","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1039\/d5cb00007f","volume":"6","author":"Y Kudo","year":"2025","unstructured":"Kudo Y, Konoki K, Yotsu-Yamashita M et al (2025) Identification of \u03b3-butyrolactone signalling molecules in diverse Actinomycetes using resin-assisted isolation and chemoenzymatic synthesis. RSC Chem Biol 6(4):630\u2013641. https:\/\/doi.org\/10.1039\/d5cb00007f","journal-title":"RSC Chem Biol"},{"issue":"4","key":"5170_CR39","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00203-005-0047-7","volume":"184","author":"KM Lee","year":"2005","unstructured":"Lee KM, Lee CK, Choi SU et al (2005) Cloning and in vivo functional analysis by disruption of a gene encoding the \u03b3-butyrolactone autoregulator receptor from Streptomyces natalensis. Arch Microbiol 184(4):249\u2013257. https:\/\/doi.org\/10.1007\/s00203-005-0047-7","journal-title":"Arch Microbiol"},{"issue":"1","key":"5170_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/srep14831","volume":"5","author":"X Li","year":"2015","unstructured":"Li X, Wang J, Li S et al (2015) ScbR-and ScbR2-mediated signal transduction networks coordinate complex physiological responses in Streptomyces coelicolor. Sci Rep 5(1):14831. https:\/\/doi.org\/10.1038\/srep14831","journal-title":"Sci Rep"},{"issue":"13","key":"5170_CR41","doi-asserted-by":"publisher","first-page":"5333","DOI":"10.1007\/s00253-017-8275-8","volume":"101","author":"X Li","year":"2017","unstructured":"Li X, Wang J, Shi M et al (2017) Evidence for the formation of ScbR\/ScbR2 heterodimers and identification of one of the regulatory targets in Streptomyces coelicolor. Appl Microbiol Biotechnol 101(13):5333\u20135340. https:\/\/doi.org\/10.1007\/s00253-017-8275-8","journal-title":"Appl Microbiol Biotechnol"},{"key":"5170_CR42","doi-asserted-by":"publisher","DOI":"10.27321\/d.cnki.gszdu.2020.001675","volume-title":"The effect of mycelial morphology and histone modification on lovastatin biosynthesis in Aspergillus terreus (in Chinese). Master\u2019s Dissertation","author":"G Liao","year":"2020","unstructured":"Liao G (2020) The effect of mycelial morphology and histone modification on lovastatin biosynthesis in Aspergillus terreus (in Chinese). Master\u2019s Dissertation. Shenzhen University, Shenzhen. https:\/\/doi.org\/10.27321\/d.cnki.gszdu.2020.001675"},{"key":"5170_CR43","doi-asserted-by":"publisher","DOI":"10.27034\/d.cnki.ggxiu.2021.001920","volume-title":"Virtual screening of \u03b3\u2013Butyrolactone functional signal molecules for Streptomyces quorum sensing (in Chinese). Master\u2019s Dissertation","author":"Y Liu","year":"2021","unstructured":"Liu Y (2021) Virtual screening of \u03b3\u2013Butyrolactone functional signal molecules for Streptomyces quorum sensing (in Chinese). Master\u2019s Dissertation. Guangxi University, Nanning. https:\/\/doi.org\/10.27034\/d.cnki.ggxiu.2021.001920"},{"issue":"1","key":"5170_CR44","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1128\/MMBR.00054-12","volume":"77","author":"G Liu","year":"2013","unstructured":"Liu G, Chater KF, Chandra G et al (2013) Molecular regulation of antibiotic biosynthesis in Streptomyces. Microbiol Mol Biol Rev 77(1):112\u2013143. https:\/\/doi.org\/10.1128\/MMBR.00054-12","journal-title":"Microbiol Mol Biol Rev"},{"key":"5170_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/FBIOE.2020.589730","volume":"8","author":"H Liu","year":"2020","unstructured":"Liu H, Zhang Y, Li S et al (2020) Elucidation of the activation pathways of ScyA1\/ScyR1, an Aco\/ArpA-like system that regulates the expression of nemadectin and other secondary metabolic biosynthetic genes. Front Bioeng Biotechnol 8:589730. https:\/\/doi.org\/10.3389\/FBIOE.2020.589730","journal-title":"Front Bioeng Biotechnol"},{"issue":"10","key":"5170_CR46","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1007\/S11427-021-1956-8","volume":"64","author":"X Liu","year":"2021","unstructured":"Liu X, Wang W, Li J et al (2021a) A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces \u03b3-butyrolactone signaling molecules. Sci China Life Sci 64(10):1575\u20131589. https:\/\/doi.org\/10.1007\/S11427-021-1956-8","journal-title":"Sci China Life Sci"},{"issue":"7","key":"5170_CR47","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.13344\/j.microbiol.china.210138","volume":"48","author":"X Liu","year":"2021","unstructured":"Liu X, Zhang Y, Wang M et al (2021b) Application of signal molecules in the discovery and development of Streptomyces natural products: a review. Microbiol China 48(7):2467\u20132482. https:\/\/doi.org\/10.13344\/j.microbiol.china.210138","journal-title":"Microbiol China"},{"issue":"1","key":"5170_CR48","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/S42003-024-06950-8","volume":"7","author":"X Liu","year":"2024","unstructured":"Liu X, Li Y, Li J et al (2024) Cinnamoyl lipids as novel signaling molecules modulate the physiological metabolism of cross-phylum microorganisms. Commun Biol 7(1):1231. https:\/\/doi.org\/10.1038\/S42003-024-06950-8","journal-title":"Commun Biol"},{"key":"5170_CR49","doi-asserted-by":"publisher","first-page":"126836","DOI":"10.1016\/J.MICRES","volume":"251","author":"NM Maimone","year":"2021","unstructured":"Maimone NM, de Oliveira LFP, Santos SN et al (2021) Elicitation of Streptomyces lunalinharesii secondary metabolism through co-cultivation with Rhizoctonia solani. Microbiol Res 251:126836. https:\/\/doi.org\/10.1016\/J.MICRES","journal-title":"Microbiol Res"},{"issue":"7","key":"5170_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002724","volume":"3","author":"S Mehra","year":"2008","unstructured":"Mehra S, Charaniya S, Takano E et al (2008) A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. PLoS One 3(7):e2724. https:\/\/doi.org\/10.1371\/journal.pone.0002724","journal-title":"PLoS One"},{"issue":"8","key":"5170_CR51","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1099\/mic.0.048371-0","volume":"157","author":"KT Miyamoto","year":"2011","unstructured":"Miyamoto KT, Kitani S, Komatsu M et al (2011) The autoregulator receptor homologue AvaR3 plays a regulatory role in antibiotic production, mycelial aggregation and colony development of Streptomyces avermitilis. Microbiology 157(8):2266\u20132275. https:\/\/doi.org\/10.1099\/mic.0.048371-0","journal-title":"Microbiology"},{"issue":"9","key":"5170_CR52","doi-asserted-by":"publisher","first-page":"e02791","DOI":"10.1128\/AEM.02791-17","volume":"84","author":"TB Nguyen","year":"2018","unstructured":"Nguyen TB, Kitani S, Shimma S et al (2018) Butenolides from Streptomyces albus J1074 act as external signals to stimulate avermectin production in Streptomyces avermitilis. Appl Environ Microbiol 84(9):e02791\u2013e02717. https:\/\/doi.org\/10.1128\/AEM.02791-17","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"5170_CR53","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1111\/j.1462-2920.2007.01314.x","volume":"9","author":"H Nishida","year":"2007","unstructured":"Nishida H, Ohnishi Y, Beppu T et al (2007) Evolution of \u03b3-butyrolactone synthases and receptors in Streptomyces. Environ Microbiol 9(8):1986\u20131994. https:\/\/doi.org\/10.1111\/j.1462-2920.2007.01314.x","journal-title":"Environ Microbiol"},{"issue":"4","key":"5170_CR54","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1093\/femsre\/fuw012","volume":"40","author":"G Niu","year":"2016","unstructured":"Niu G, Chater KF, Tian Y et al (2016) Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp. FEMS Microbiol Rev 40(4):554\u2013573. https:\/\/doi.org\/10.1093\/femsre\/fuw012","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"5170_CR55","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1111\/mmi.12787","volume":"94","author":"JR Nodwell","year":"2014","unstructured":"Nodwell JR (2014) Are you talking to me? A possible role for \u03b3-butyrolactones in interspecies signalling. Mol Microbiol 94(3):483\u2013485. https:\/\/doi.org\/10.1111\/mmi.12787","journal-title":"Mol Microbiol"},{"issue":"2","key":"5170_CR56","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1584\/jpestics.d21-014","volume":"46","author":"A Okazawa","year":"2021","unstructured":"Okazawa A, Samejima H, Kitani S et al (2021) Germination stimulatory activity of bacterial butenolide hormones from Streptomyces albus J1074 on seeds of the root parasitic weed Orobanche minor. J Pestic Sci 46(2):242\u2013247. https:\/\/doi.org\/10.1584\/jpestics.d21-014","journal-title":"J Pestic Sci"},{"issue":"2","key":"5170_CR57","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/microorganisms2020111","volume":"2","author":"EK Palonen","year":"2014","unstructured":"Palonen EK, Neffling MR, Raina S et al (2014) Butyrolactone I quantification from lovastatin producing Aspergillus terreus using tandem mass spectrometry\u2014evidence of signalling functions. Microorganisms 2(2):111\u2013127. https:\/\/doi.org\/10.3390\/microorganisms2020111","journal-title":"Microorganisms"},{"issue":"9","key":"5170_CR58","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nrmicro.2016.89","volume":"14","author":"K Papenfort","year":"2016","unstructured":"Papenfort K, Bassler BL (2016) Quorum sensing signal\u2013response systems in Gram-negative bacteria. Nat Rev Microbiol 14(9):576\u2013588. https:\/\/doi.org\/10.1038\/nrmicro.2016.89","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"5170_CR59","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.procbio.2012.02.021","volume":"47","author":"S Raina","year":"2012","unstructured":"Raina S, De Vizio D, Palonen EK et al (2012) Is quorum sensing involved in lovastatin production in the filamentous fungus Aspergillus terreus? Process Biochem 47(5):843\u2013852. https:\/\/doi.org\/10.1016\/j.procbio.2012.02.021","journal-title":"Process Biochem"},{"issue":"40","key":"5170_CR60","doi-asserted-by":"publisher","first-page":"41586","DOI":"10.1074\/jbc.m402340200","volume":"279","author":"E Recio","year":"2004","unstructured":"Recio E, Colinas A, Rumbero A et al (2004) PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis. J Biol Chem 279(40):41586\u201341593. https:\/\/doi.org\/10.1074\/jbc.m402340200","journal-title":"J Biol Chem"},{"key":"5170_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/FMICB.2024.1342637","volume":"15","author":"A Salehi-Najafabadi","year":"2024","unstructured":"Salehi-Najafabadi A, Tehrani Fateh S, Amoabediny G et al (2024) Insights into additional lactone-based signaling circuits in Streptomyces: existence of acyl-homoserine lactones and LuxI\/LuxR homologs in six Streptomyces species. Front Microbiol 15:1342637. https:\/\/doi.org\/10.3389\/FMICB.2024.1342637","journal-title":"Front Microbiol"},{"issue":"34","key":"5170_CR62","doi-asserted-by":"publisher","first-page":"14558","DOI":"10.1073\/pnas.0901870106","volume":"106","author":"V Schroeckh","year":"2009","unstructured":"Schroeckh V, Scherlach K, N\u00fctzmann HW et al (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34):14558\u201363. https:\/\/doi.org\/10.1073\/pnas.0901870106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5170_CR63","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/B978-0-12-404634-4.00004-8","volume":"517","author":"JD Sidda","year":"2012","unstructured":"Sidda JD, Corre C (2012) Chapter four - gamma-butyrolactone and furan signaling systems in Streptomyces. Methods Enzymol 517:71\u201387. https:\/\/doi.org\/10.1016\/B978-0-12-404634-4.00004-8","journal-title":"Methods Enzymol"},{"key":"5170_CR64","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5283948","author":"P Sivalingam","year":"2019","unstructured":"Sivalingam P, Hong K, Pote J et al (2019) Extreme environment Streptomyces: potential sources for new antibacterial and anticancer drug leads? Int J Microbiol. https:\/\/doi.org\/10.1155\/2019\/5283948","journal-title":"Int J Microbiol"},{"key":"5170_CR65","doi-asserted-by":"publisher","DOI":"10.64898\/2026.04.27.721074","author":"MI Stoutland","year":"2026","unstructured":"Stoutland MI, Walker AS, Blackwell EH (2026) Domain-swapped LuxR-type quorum sensing receptors reveal divergent ligand-response mechanisms among homologs. bioRxiv. https:\/\/doi.org\/10.64898\/2026.04.27.721074","journal-title":"bioRxiv"},{"key":"5170_CR66","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52541","volume":"9","author":"MC Stroe","year":"2020","unstructured":"Stroe MC, Netzker T, Scherlach K et al (2020) Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin. eLife 9:e52541. https:\/\/doi.org\/10.7554\/eLife.52541","journal-title":"eLife"},{"issue":"22","key":"5170_CR67","doi-asserted-by":"publisher","first-page":"9581","DOI":"10.1007\/s00253-016-7781-4","volume":"100","author":"SP Sultan","year":"2016","unstructured":"Sultan SP, Kitani S, Miyamoto KT et al (2016) Characterization of AvaR1, a butenolide-autoregulator receptor for biosynthesis of a Streptomyces hormone in Streptomyces avermitilis. Appl Microbiol Biotechnol 100(22):9581\u20139591. https:\/\/doi.org\/10.1007\/s00253-016-7781-4","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"5170_CR68","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.mib.2006.04.003","volume":"9","author":"E Takano","year":"2006","unstructured":"Takano E (2006) \u03b3-Butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation. Curr Opin Microbiol 9(3):287\u2013294. https:\/\/doi.org\/10.1016\/j.mib.2006.04.003","journal-title":"Curr Opin Microbiol"},{"issue":"11","key":"5170_CR69","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1360\/SSV-2025-0089","volume":"55","author":"Q Tian","year":"2025","unstructured":"Tian Q, Gang J, Wang L et al (2025) Research progress on AdpA: a pleiotropic regulator for Streptomyces antibiotic synthesis. Sci China Life Sci 55(11):2434\u20132449. https:\/\/doi.org\/10.1360\/SSV-2025-0089","journal-title":"Sci China Life Sci"},{"issue":"2","key":"5170_CR70","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/microorganisms6020052","volume":"6","author":"AP Tyurin","year":"2018","unstructured":"Tyurin AP, Alferova VA, Korshun VA et al (2018) Chemical elicitors of antibiotic biosynthesis in Actinomycetes. Microorganisms 6(2):52. https:\/\/doi.org\/10.3390\/microorganisms6020052","journal-title":"Microorganisms"},{"issue":"16","key":"5170_CR71","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1128\/jb.179.16.5131-5137.1997","volume":"179","author":"M Waki","year":"1997","unstructured":"Waki M, Nihira T, Yamada Y et al (1997) Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5. J Bacteriol 179(16):5131\u20135137. https:\/\/doi.org\/10.1128\/jb.179.16.5131-5137.1997","journal-title":"J Bacteriol"},{"issue":"8","key":"5170_CR72","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1099\/mic.0.26209-0","volume":"149","author":"L Wang","year":"2003","unstructured":"Wang L, Vining LC (2003) Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae ISP5230 by jadW1, a member of the afsA family of \u03b3-butyrolactone regulatory genes. Microbiology (Reading) 149(8):1991\u20132004. https:\/\/doi.org\/10.1099\/mic.0.26209-0","journal-title":"Microbiology (Reading)"},{"issue":"4","key":"5170_CR73","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s10529-013-1416-y","volume":"36","author":"J Wang","year":"2014","unstructured":"Wang J, Zhang F, Pu J et al (2014a) Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. Biotechnol Lett 36(4):813\u2013819. https:\/\/doi.org\/10.1007\/s10529-013-1416-y","journal-title":"Biotechnol Lett"},{"issue":"15","key":"5170_CR74","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.1073\/pnas.1324253111","volume":"111","author":"W Wang","year":"2014","unstructured":"Wang W, Ji J, Li X et al (2014b) Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. Proc Natl Acad Sci USA 111(15):5688\u20135693. https:\/\/doi.org\/10.1073\/pnas.1324253111","journal-title":"Proc Natl Acad Sci USA"},{"key":"5170_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiotec.2015.03.012","volume":"204","author":"H Wang","year":"2015","unstructured":"Wang H, Li C, Zhang B et al (2015) Complete genome sequence of Streptomyces cyaneogriseus ssp. noncyanogenus, the thermotolerant producer of commercial antibiotics nemadectin. J Biotechnol 204:1\u20132. https:\/\/doi.org\/10.1016\/j.jbiotec.2015.03.012","journal-title":"J Biotechnol"},{"issue":"52","key":"5170_CR76","doi-asserted-by":"publisher","first-page":"20029","DOI":"10.1074\/jbc.ra118.005667","volume":"293","author":"W Wang","year":"2018","unstructured":"Wang W, Zhang J, Liu X et al (2018) Identification of a butenolide signaling system that regulates nikkomycin biosynthesis in Streptomyces. J Biol Chem 293(52):20029\u201320040. https:\/\/doi.org\/10.1074\/jbc.ra118.005667","journal-title":"J Biol Chem"},{"key":"5170_CR77","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.vetmic.2019.05.006","volume":"233","author":"Y Wang","year":"2019","unstructured":"Wang Y, Liu B, Li J et al (2019) LuxS\/AI-2 system is involved in fluoroquinolones susceptibility in Streptococcus suis through overexpression of efflux pump SatAB. Vet Microbiol 233:154\u2013158. https:\/\/doi.org\/10.1016\/j.vetmic.2019.05.006","journal-title":"Vet Microbiol"},{"issue":"7","key":"5170_CR78","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1021\/ACSCHEMBIO.3C00241","volume":"18","author":"LE Wilbanks","year":"2023","unstructured":"Wilbanks LE, Hennigan HE, Martinez-Brokaw CD et al (2023) Synthesis of gamma-butyrolactone hormones enables understanding of natural product induction. ACS Chem Biol 18(7):1624\u20131631. https:\/\/doi.org\/10.1021\/ACSCHEMBIO.3C00241","journal-title":"ACS Chem Biol"},{"issue":"12","key":"5170_CR79","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.chembiol.2014.10.008","volume":"21","author":"F Wu","year":"2014","unstructured":"Wu F, Menn DJ, Wang X et al (2014) Quorum-sensing crosstalk-driven synthetic circuits: from unimodality to trimodality. Chem Biol 21(12):1629\u20131638. https:\/\/doi.org\/10.1016\/j.chembiol.2014.10.008","journal-title":"Chem Biol"},{"issue":"1","key":"5170_CR80","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.synbio.2016.01.004","volume":"1","author":"H Wu","year":"2016","unstructured":"Wu H, Wang Y, Yuan L et al (2016) Inactivation of SACE3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea. Synth Syst Biotechnol 1(1):39\u201346. https:\/\/doi.org\/10.1016\/j.synbio.2016.01.004","journal-title":"Synth Syst Biotechnol"},{"key":"5170_CR81","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3389\/fmicb.2016.00958","volume":"7","author":"G Xu","year":"2016","unstructured":"Xu G (2016) Relationships between the regulatory systems of quorum sensing and multidrug resistance. Front Microbiol 7:958. https:\/\/doi.org\/10.3389\/fmicb.2016.00958","journal-title":"Front Microbiol"},{"issue":"23","key":"5170_CR82","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.1007\/s00253-019-10219-0","volume":"103","author":"G Xu","year":"2019","unstructured":"Xu G, Yang S (2019) Regulatory and evolutionary roles of pseudo \u03b3-butyrolactone receptors in antibiotic biosynthesis and resistance. Appl Microbiol Biotechnol 103(23):9373\u20139378. https:\/\/doi.org\/10.1007\/s00253-019-10219-0","journal-title":"Appl Microbiol Biotechnol"},{"issue":"35","key":"5170_CR83","doi-asserted-by":"publisher","first-page":"27440","DOI":"10.1074\/jbc.m110.143081","volume":"285","author":"G Xu","year":"2010","unstructured":"Xu G, Wang J, Wang L et al (2010) Pseudo \u03b3-butyrolactone receptors respond to antibiotic signals to coordinate antibiotic biosynthesis. J Biol Chem 285(35):27440\u201327448. https:\/\/doi.org\/10.1074\/jbc.m110.143081","journal-title":"J Biol Chem"},{"issue":"48","key":"5170_CR84","doi-asserted-by":"publisher","first-page":"19708","DOI":"10.1074\/jbc.M117.809145","volume":"292","author":"J Xu","year":"2017","unstructured":"Xu J, Zhang J, Zhuo J et al (2017) Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene, adpA, in Streptomyces ansochromogenes. J Biol Chem 292(48):19708\u201319720. https:\/\/doi.org\/10.1074\/jbc.M117.809145","journal-title":"J Biol Chem"},{"issue":"2","key":"5170_CR85","doi-asserted-by":"publisher","first-page":"717","DOI":"10.13343\/j.cnki.wsxb.20220450","volume":"63","author":"L Ye","year":"2023","unstructured":"Ye L, Liu H, Li S et al (2023) Global function characterization of an Aco-like autoregulator synthase ScyA1 in Streptomyces cyaneogriseus. Acta Microbiol Sinica 63(2):717\u2013730. https:\/\/doi.org\/10.13343\/j.cnki.wsxb.20220450","journal-title":"Acta Microbiol Sinica"},{"key":"5170_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143031","volume":"763","author":"L Yi","year":"2021","unstructured":"Yi L, Dong X, Grenier D et al (2021) Research progress of bacterial quorum sensing receptors: classification, structure, function and characteristics. Sci Total Environ 763:143031. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.143031","journal-title":"Sci Total Environ"},{"issue":"3","key":"5170_CR87","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/jobm.201600498","volume":"57","author":"J Yu","year":"2017","unstructured":"Yu J, Liu Q, Chen C et al (2017) Antifungal activity change of Streptomyces rimosus MY02 mediated by confront culture with other microorganism. J Basic Microbiol 57(3):276\u2013282. https:\/\/doi.org\/10.1002\/jobm.201600498","journal-title":"J Basic Microbiol"},{"issue":"7","key":"5170_CR88","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s11427-013-4508-y","volume":"56","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Zou Z, Niu G et al (2013) jadR* and jadR2 act synergistically to repress jadomycin biosynthesis. Sci China Life Sci 56(7):584\u2013590. https:\/\/doi.org\/10.1007\/s11427-013-4508-y","journal-title":"Sci China Life Sci"},{"issue":"4","key":"5170_CR89","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1007\/s00253-019-10329-9","volume":"104","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Wang M, Tian J et al (2020) Activation of paulomycin production by exogenous \u03b3-butyrolactone signaling molecules in Streptomyces albidoflavus J1074. Appl Microbiol Biotechnol 104(4):1695\u20131705. https:\/\/doi.org\/10.1007\/s00253-019-10329-9","journal-title":"Appl Microbiol Biotechnol"},{"key":"5170_CR90","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01077-21","author":"X Zhang","year":"2021","unstructured":"Zhang X, Andres SN, Elliot MA (2021) Interplay between nucleoid-associated proteins and transcription factors in controlling specialized metabolism in Streptomyces. mBio. https:\/\/doi.org\/10.1128\/mbio.01077-21","journal-title":"mBio"},{"issue":"4","key":"5170_CR91","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/mmi.13479","volume":"102","author":"J Zhu","year":"2016","unstructured":"Zhu J, Sun D, Liu W et al (2016) AvaR2, a pseudo \u03b3-butyrolactone receptor homologue from Streptomyces avermitilis, is a pleiotropic repressor of avermectin and avenolide biosynthesis and cell growth. Mol Microbiol 102(4):562\u2013578. https:\/\/doi.org\/10.1111\/mmi.13479","journal-title":"Mol Microbiol"},{"key":"5170_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02577","volume":"8","author":"J Zhu","year":"2017","unstructured":"Zhu J, Chen Z, Li J et al (2017) AvaR1, a butenolide-type autoregulator receptor in Streptomyces avermitilis, directly represses avenolide and avermectin biosynthesis and multiple physiological responses. Front Microbiol 8:2577. https:\/\/doi.org\/10.3389\/fmicb.2017.02577","journal-title":"Front Microbiol"},{"issue":"3","key":"5170_CR93","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/mmi.12752","volume":"94","author":"Z Zou","year":"2014","unstructured":"Zou Z, Du D, Zhang Y et al (2014) A \u03b3-butyrolactone\u2010sensing activator\/repressor, JadR3, controls a regulatory mini\u2010network for jadomycin biosynthesis. Mol Microbiol 94(3):490\u2013505. https:\/\/doi.org\/10.1111\/mmi.12752","journal-title":"Mol Microbiol"}],"container-title":["Archives of Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00203-026-05170-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00203-026-05170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:58:23Z","timestamp":1788681503000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00203-026-05170-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":93,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["5170"],"URL":"https:\/\/doi.org\/10.1007\/s00203-026-05170-4","relation":{},"ISSN":["0302-8933","1432-072X"],"issn-type":[{"value":"0302-8933","type":"print"},{"value":"1432-072X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]},"assertion":[{"value":"24 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"611"}}