{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:17:50Z","timestamp":1785709070141,"version":"3.56.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T00:00:00Z","timestamp":1163462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s00204-006-0161-6","type":"journal-article","created":{"date-parts":[[2006,11,15]],"date-time":"2006-11-15T20:00:48Z","timestamp":1163620848000},"page":"335-346","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Human experimental exposure study on the uptake and urinary elimination of N-methyl-2-pyrrolidone (NMP) during simulated workplace conditions"],"prefix":"10.1007","volume":"81","author":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Wrbitzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinolf","family":"Blaszkewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"van Thriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"161_CR1","unstructured":"\u00c5kesson B (2001) N-Methyl-2-pyrrolidone. Concise international chemical assessment document 35, International programme on chemical safety, World Health Organization, Geneva"},{"key":"161_CR2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5271\/sjweh.799","volume":"30","author":"B \u00c5kesson","year":"2004","unstructured":"\u00c5kesson B, Carnerup M, J\u00f6nsson BAG (2004) Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scand J Work Environ Health 30:306\u2013312","journal-title":"Scand J Work Environ Health"},{"key":"161_CR3","first-page":"267","volume":"25","author":"B \u00c5kesson","year":"1997","unstructured":"\u00c5kesson B, J\u00f6nsson BAG (1997) Major metabolic pathway for N-methyl-2-pyrrolidone in humans. Drug Metab Dispos 25:267\u2013269","journal-title":"Drug Metab Dispos"},{"key":"161_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5271\/sjweh.534","volume":"26","author":"B \u00c5kesson","year":"2000","unstructured":"\u00c5kesson B, J\u00f6nsson BAG (2000) Biological monitoring of N-methyl-2-pyrrolidone using 5-hydroxy-N-methyl-2-pyrrolidone in plasma and urine as the biomarker. Scand J Work Environ Health 26:213\u2013218","journal-title":"Scand J Work Environ Health"},{"key":"161_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1136\/oem.54.4.236","volume":"54","author":"B \u00c5kesson","year":"1997","unstructured":"\u00c5kesson B, Paulsson K (1997) Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine. Occup Environ Med 54:236\u2013240","journal-title":"Occup Environ Med"},{"key":"161_CR6","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0378-4274(02)00175-3","volume":"134","author":"P Akrill","year":"2002","unstructured":"Akrill P, Cocker J, Dixon S (2002) Dermal exposure to aqueous solutions of N-methylpyrrolidone. Toxicol Lett 134:265\u2013269","journal-title":"Toxicol Lett"},{"key":"161_CR7","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s004200000157","volume":"73","author":"H Anundi","year":"2000","unstructured":"Anundi H, Langworth S, Johanson G, Lind ML, \u00c5kesson B, Friis L, Itkes N, S\u00f6derman E, J\u00f6nsson BAG, Edling C (2000) Air and biological monitoring of solvent exposure during graffiti removal. Int Arch Occup Environ Health 73:561\u2013569","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/BF00381198","volume":"65","author":"H Anundi","year":"1993","unstructured":"Anundi H, Lind ML, Friis L, Itkes N, Langworth S, Edling C (1993) High exposures to organic solvents among graffiti removers. Int Arch Occup Environ Health 65:247\u2013251","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR9","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s00420-005-0008-0","volume":"78","author":"M Bader","year":"2005","unstructured":"Bader M, Keener SA, Wrbitzky R (2005) Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone. Int Arch Occup Environ Health 78:673\u2013676","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00420-005-0065-4","volume":"79","author":"M Bader","year":"2006","unstructured":"Bader M, Rosenberger W, Rebe Th, Keener S, Brock TH, Hemmerling H, Wrbitzky R (2006) Ambient monitoring and biomonitoring of workers exposed to N-methyl-2-pyrrolidone (NMP) in an industrial facility. Int Arch Occup Environ Health 79:357\u2013364","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR11","first-page":"422","volume":"9","author":"M Bader","year":"2002","unstructured":"Bader M, Will W, Rossbacher R, Nasterlack M, Wrbitzky R (2002) N-Methyl-2-pyrrolidon - Arbeitsmedizinische Bedeutung und Toxikologie. Arbeitsmed Sozialmed Umweltmed 9:422\u2013428","journal-title":"Arbeitsmed Sozialmed Umweltmed"},{"key":"161_CR12","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/1047322X.1991.10387980","volume":"6","author":"HJ Beaulieu","year":"1991","unstructured":"Beaulieu HJ, Schmerber KR (1991) M-Pyrol(TM) (NMP) use in the microelectronics industry. Appl Occup Environ Hyg 6:874\u2013880","journal-title":"Appl Occup Environ Hyg"},{"key":"161_CR13","unstructured":"Carnerup MA (2004) Analysis, metabolism, effects and biological monitoring of N-methyl-2-pyrrolidone (NMP). Thesis, Faculty of Medicine, Lund University, Sweden"},{"key":"161_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.toxlet.2005.09.035","volume":"162","author":"MA Carnerup","year":"2006","unstructured":"Carnerup MA, Spanne M, J\u00f6nsson BA (2006) Levels of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine from volunteers after experimental exposure to NMP in dry and humid air. Toxicol Lett 162:139\u201345","journal-title":"Toxicol Lett"},{"key":"161_CR15","unstructured":"DFG (Deutsche Forschungsgemeinschaft) (2006) List of MAK and BAT values 2006. Report No. 42, Wiley-VCH, Weinheim"},{"key":"161_CR16","unstructured":"Greim H (ed.) (2006) N-Methyl-2-pyrrolidon (Dampf). Maximale Arbeitsplatzkonzentrationen. Arbeitsmedizinisch-toxikologische Begr\u00fcndungen. Senatskommission zur Pr\u00fcfung gesundheitssch\u00e4dlicher Arbeitsstoffe. Deutsche Forschungsgemeinschaft. 41. Lieferung, Wiley-VCH, Weinheim"},{"key":"161_CR17","unstructured":"Greim H, Lehnert G (eds.) (1998) Die Bedeutung der Arbeitsleistung f\u00fcr die Inhalationskinetik. Toxikologisch-arbeitsmedizinische Begr\u00fcndungen von MAK-Werten, Senatskommission zur Pr\u00fcfung gesundheitssch\u00e4dlicher Arbeitsstoffe. Deutsche Forschungsgemeinschaft. 27. Lieferung, Wiley-VCH, Weinheim"},{"key":"161_CR18","unstructured":"HSE (Health and Safety Executive) (1997) N-Methyl-2-pyrrolidone. Risk assessment document. EH72\/10, ISBN 0717615286, HSE Books, Sudbury, UK"},{"key":"161_CR19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S0378-4347(97)00125-4","volume":"694","author":"BAG J\u00f6nsson","year":"1997","unstructured":"J\u00f6nsson BAG, \u00c5kesson B (1997) Determination of 5-hydroxy-N-methylpyrrolidone and 2-hydroxy-N-methylsuccinimide in human urine. J Chrom B 694:351\u2013357","journal-title":"J Chrom B"},{"key":"161_CR20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00420-003-0438-5","volume":"76","author":"BAG J\u00f6nsson","year":"2003","unstructured":"J\u00f6nsson BAG, \u00c5kesson B (2003) Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy-N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI) and biological monitoring using 2-HMSI as a biomarker. Int Arch Occup Environ Health 76:267\u2013274","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s004200000211","volume":"74","author":"S Langworth","year":"2001","unstructured":"Langworth S, Anundi H, Friis L, Johanson G, Lind ML, S\u00f6derman E, \u00c5kesson B (2001) Acute health effects common during graffiti removal. Int Arch Occup Environ Health 74:213\u2013218","journal-title":"Int Arch Occup Environ Health"},{"key":"161_CR22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00204-003-0440-4","volume":"77","author":"D Ligocka","year":"2003","unstructured":"Ligocka D, Lison D, Haufroid V (2003) Contribution of CYP2E1 to N-methyl-2-pyrrolidone metabolism. Arch Toxicol 77:261\u2013266","journal-title":"Arch Toxicol"},{"key":"161_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0278-6915(92)90137-A","volume":"30","author":"I Midgley","year":"1992","unstructured":"Midgley I, Hood AJ, Chasseaud LF, Brindley CJ, Baughman S, Allan G (1992) Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat. Food Chem Toxic 30:57\u201364","journal-title":"Food Chem Toxic"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-006-0161-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-006-0161-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-006-0161-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-006-0161-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T21:09:59Z","timestamp":1652821799000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-006-0161-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,14]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["161"],"URL":"https:\/\/doi.org\/10.1007\/s00204-006-0161-6","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,14]]},"assertion":[{"value":"18 September 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}