{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:00:25Z","timestamp":1787317225663,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T00:00:00Z","timestamp":1173312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2007,8,3]]},"DOI":"10.1007\/s00204-007-0189-2","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T06:29:16Z","timestamp":1173248956000},"page":"655-663","source":"Crossref","is-referenced-by-count":49,"title":["Protective effects of ibuprofen on testicular torsion\/detorsion-induced ischemia\/reperfusion injury in rats"],"prefix":"10.1007","volume":"81","author":[{"given":"Dikmen","family":"Dokmeci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kanter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Inan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurettin","family":"Aydogdu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umit Nusret","family":"Basaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nesrin","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,3,8]]},"reference":[{"key":"189_CR1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jpedsurg.2004.04.018","volume":"39","author":"A Abasiyanik","year":"2004","unstructured":"Abasiyanik A, Dagdonderen L (2004) Beneficial effects of melatonin compared with allopurinol in experimental testicular torsion. J Pediatr Surg 39:1238\u20131241","journal-title":"J Pediatr Surg"},{"key":"189_CR2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1464-410X.2005.05328.x","volume":"95","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Said TM (2005) Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int 95:503\u2013507","journal-title":"BJU Int"},{"key":"189_CR3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S1472-6483(10)61641-0","volume":"8","author":"A Agarwal","year":"2004","unstructured":"Agarwal A, Nallella KP, Allamaneni SS, Said TM (2004) Role of antioxidants in treatment of male infertility: an overview of the literature. Reprod Biomed Online 8:616\u2013627","journal-title":"Reprod Biomed Online"},{"key":"189_CR4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2005.12.026","volume":"250","author":"RJ Aitken","year":"2006","unstructured":"Aitken RJ, Baker MA (2006) Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol 250:66\u201369","journal-title":"Mol Cell Endocrinol"},{"key":"189_CR5","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.fertnstert.2004.05.106","volume":"83","author":"SS Allamaneni","year":"2005","unstructured":"Allamaneni SS, Agarwal A, Nallella KP, Sharma RK, Thomas AJ Jr, Sikka SC (2005) Characterization of oxidative stress status by evaluation of reactive oxygen species levels in whole semen and isolated spermatozoa. Fertil Steril 83:800\u2013803","journal-title":"Fertil Steril"},{"key":"189_CR6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00383-005-1365-1","volume":"21","author":"D Avlan","year":"2005","unstructured":"Avlan D, Erdougan K, Cimen B, Dusmez Apa D, Cinel I, Aksoyek S (2005) The protective effect of selenium on ipsilateral and contralateral testes in testicular reperfusion injury. Pediatr Surg Int 21:274\u2013278","journal-title":"Pediatr Surg Int"},{"key":"189_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1021311029572","volume":"34","author":"M Barlas","year":"2002","unstructured":"Barlas M, Hatiboglu C (2002) The effect of nitric oxide in testicular ischemia\u2013reperfusion injury. Int Urol Nephrol 34:81\u201386","journal-title":"Int Urol Nephrol"},{"key":"189_CR8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jss.2005.11.572","volume":"131","author":"A Cay","year":"2006","unstructured":"Cay A, Alver A, Kucuk M, Isik O, Eminagaoglu MS, Karahan SC, Deger O (2006) The effects of N-acetylcysteine on antioxidant enzyme activities in experimental testicular torsion. J Surg Res 131:199\u2013203","journal-title":"J Surg Res"},{"key":"189_CR9","first-page":"5","volume":"46","author":"D Dokmeci","year":"2004","unstructured":"Dokmeci D (2004) Ibuprofen and Alzheimer\u2019s disease. Folia Med (Plovdiv) 46:5\u201310","journal-title":"Folia Med (Plovdiv)"},{"key":"189_CR10","first-page":"26","volume":"47","author":"D Dokmeci","year":"2005","unstructured":"Dokmeci D (2005) Oxidative stress, male infertility and the role of carnitines. Folia Med (Plovdiv) 47:26\u201330","journal-title":"Folia Med (Plovdiv)"},{"key":"189_CR11","first-page":"125","volume-title":"New research on Alzheimer\u2019s disease","author":"D Dokmeci","year":"2006","unstructured":"Dokmeci D (2006) The role of peroxisome proliferator-activated receptors in Alzheimer\u2019s disease. In: Welsh Eileen M (ed) New research on Alzheimer\u2019s disease. Nova Science, New York, pp 125\u2013163"},{"key":"189_CR12","first-page":"67","volume":"52","author":"D Dokmeci","year":"2004","unstructured":"Dokmeci D, Akpolat M, Aydogdu N, Uzal C, Turan NF (2004) The modifying effect of ibuprofen on total body irradiation-induced elevation of oxidative reactions in male hamsters. Acta Med Biol 52:67\u201372","journal-title":"Acta Med Biol"},{"key":"189_CR13","doi-asserted-by":"crossref","unstructured":"Dokmeci D, Inan M, Basaran UN, Yalcin O, Aydogdu N, Turan FN, Uz YH (2006) Protective effect of l-carnitine on testicular ischaemia\u2013reperfusion injury in rats. Cell Biochem Funct (in press)","DOI":"10.1002\/cbf.1355"},{"key":"189_CR14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1046\/j.1464-410x.2000.00529.x","volume":"85","author":"AI Dokucu","year":"2000","unstructured":"Dokucu AI, Ozturk H, Ozdemir E, Ketani A, Buyukbayram H, Yucesan S (2000) The protective effects of nitric oxide on the contralateral testis in prepubertal rats with unilateral testicular torsion. BJU Int 85:767\u2013771","journal-title":"BJU Int"},{"key":"189_CR15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mam.2004.02.020","volume":"25","author":"DW Filho","year":"2004","unstructured":"Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A (2004) Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 25:199\u2013210","journal-title":"Mol Aspects Med"},{"key":"189_CR16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/jpet.103.064667","volume":"310","author":"ER Gross","year":"2004","unstructured":"Gross ER, Hsu AK, Gross GJ (2004) Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: role of 12-lipoxygenase. J Pharmacol Exp Ther 310:185\u2013191","journal-title":"J Pharmacol Exp Ther"},{"key":"189_CR17","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"1999","unstructured":"Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine, 3rd edn. Oxford University Press, London","edition":"3rd edn."},{"key":"189_CR18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/10715769009145692","volume":"9","author":"SA Hamburger","year":"1990","unstructured":"Hamburger SA, McCay PB (1990) Spin trapping of ibuprofen radicals: evidence that ibuprofen is a hydroxyl radical scavenger. Free Radic Res Commun 9:337\u2013342","journal-title":"Free Radic Res Commun"},{"key":"189_CR19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","volume":"29","author":"SM Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Fanger H (1981) Use of avidin\u2013biotin-peroxidase complex (ABC) in immunperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577\u2013580","journal-title":"J Histochem Cytochem"},{"key":"189_CR20","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0006-2952(01)00822-X","volume":"62","author":"MS Jaradat","year":"2001","unstructured":"Jaradat MS, Wongsud B, Phornchirasilp S, Rangwala SM, Shams G, Sutton M, Romstedt KJ, Noonan DJ, Feller DR (2001) Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin. Biochem Pharmacol 62:1587\u20131595","journal-title":"Biochem Pharmacol"},{"key":"189_CR21","first-page":"2","volume":"1","author":"SG Johnsen","year":"1970","unstructured":"Johnsen SG (1970) Testicular biopsy score count\u2014a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2\u201325","journal-title":"Hormones"},{"key":"189_CR22","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1172\/JCI114876","volume":"86","author":"TP Kennedy","year":"1990","unstructured":"Kennedy TP, Rao NV, Noah W, Michael JR, Jafri MH Jr, Gurtner GH, Hoidal JR (1990) Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J Clin Invest 86:1565\u20131573","journal-title":"J Clin Invest"},{"key":"189_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0009-8981(97)00089-2","volume":"275","author":"D Konukoglu","year":"1998","unstructured":"Konukoglu D, Tasci I, Cetinkale O (1998) Effects of cyclosporin A and ibuprofen on liver ischemia\u2013reperfusion injury in the rat. Clin Chim Acta 275:1\u20138","journal-title":"Clin Chim Acta"},{"key":"189_CR24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00000637-199403000-00013","volume":"32","author":"C Lee","year":"1994","unstructured":"Lee C, Kerrigan CL (1994) Ibuprofen treatment of ischemic musculocutaneous flaps. Ann Plast Surg 32:300\u2013304","journal-title":"Ann Plast Surg"},{"key":"189_CR25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00383-005-1580-9","volume":"22","author":"JG Mogilner","year":"2006","unstructured":"Mogilner JG, Lurie M, Coran AG, Nativ O, Shiloni E, Sukhotnik I (2006) Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat. Pediatr Surg Int 22:99\u2013105","journal-title":"Pediatr Surg Int"},{"key":"189_CR26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1292\/jvms.67.453","volume":"67","author":"C Moon","year":"2005","unstructured":"Moon C, Ahn M, Kim S, Yasuzumi F, Shin T (2005) Increased expression of both constitutive and inducible forms of nitric oxide synthase in the delayed phase of acute experimental testicular torsion. J Vet Med Sci 67:453\u2013456","journal-title":"J Vet Med Sci"},{"key":"189_CR27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay of lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal Biochem 95:351\u2013358","journal-title":"Anal Biochem"},{"key":"189_CR28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-3468(00)80023-8","volume":"35","author":"BH Ozokutan","year":"2000","unstructured":"Ozokutan BH, Kucukaydin M, Muhtaroglu S, Tekin Y (2000) The role of nitric oxide in testicular ischemia\u2013reperfusion injury. J Pediatr Surg 35:101\u2013103","journal-title":"J Pediatr Surg"},{"key":"189_CR29","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0022-3468(03)00573-6","volume":"38","author":"H Ozturk","year":"2003","unstructured":"Ozturk H, Buyukbayram H, Ozdemir E, Ketani A, Gurel A, Onen A, Otcu S (2003) The effects of nitric oxide on the expression of cell adhesion molecules (ICAM-1, UEA-1, and tenascin) in rats with unilateral testicular torsion. J Pediatr Surg 38:1621\u20131627","journal-title":"J Pediatr Surg"},{"key":"189_CR30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neuroscience.2005.01.021","volume":"132","author":"EM Park","year":"2005","unstructured":"Park EM, Cho BP, Volpe BT, Cruz MO, Joh TH, Cho S (2005) Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. Neuroscience 132:625\u2013631","journal-title":"Neuroscience"},{"key":"189_CR31","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1006\/exer.2001.1156","volume":"74","author":"JM Rieger","year":"2002","unstructured":"Rieger JM, Shah AR, Gidday JM (2002) Ischemia\u2013reperfusion injury of retinal endothelium by cyclooxygenase- and xanthine oxidase-derived superoxide. Exp Eye Res 74:493\u2013501","journal-title":"Exp Eye Res"},{"key":"189_CR32","first-page":"53","volume":"299","author":"DJ Schmeling","year":"1989","unstructured":"Schmeling DJ, Drongowski RA, Coran AG (1989) The beneficial effects of ibuprofen on a lethal live E. coli septic shock model and the relationship of these effects to superoxide radical production. Prog Clin Biol Res 299:53\u201361","journal-title":"Prog Clin Biol Res"},{"key":"189_CR33","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1095\/biolreprod65.2.514","volume":"65","author":"K Shiraishi","year":"2001","unstructured":"Shiraishi K, Naito K, Yoshida K (2001) Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat. Biol Reprod 65:514\u2013521","journal-title":"Biol Reprod"},{"key":"189_CR34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10552-005-0411-6","volume":"17","author":"ML Slattery","year":"2006","unstructured":"Slattery ML, Curtin K, Wolff R, Ma KN, Sweeney C, Murtaugh M, Potter JD, Levin TR, Samowitz W (2006) PPAR gamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). Cancer Causes Control 17:239\u2013249","journal-title":"Cancer Causes Control"},{"key":"189_CR35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/00365590500407514","volume":"40","author":"A Unsal","year":"2006","unstructured":"Unsal A, Eroglu M, Avci A, Cimentepe E, Guven C, Derya Balbay M, Durak I (2006) Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion. Scand J Urol Nephrol 40:17\u201322","journal-title":"Scand J Urol Nephrol"},{"key":"189_CR36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0925-4439(98)00105-7","volume":"1453","author":"K Yoshida","year":"1999","unstructured":"Yoshida K, Mizukami Y, Kitakaze M (1999) Nitric oxide mediates protein kinase C isoform translocation in rat heart during postischemic reperfusion. Biochim Biophys Acta 1453:230\u2013238","journal-title":"Biochim Biophys Acta"},{"key":"189_CR37","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/S0024-3205(99)00496-8","volume":"65","author":"D Zapolska-Downar","year":"1999","unstructured":"Zapolska-Downar D, Zapolska-Downar A, Bukowska H, Galka H, Naruszewicz M (1999) Ibuprofen protects low density lipoproteins against oxidative modification. Life Sci 65:2289\u20132303","journal-title":"Life Sci"},{"key":"189_CR38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1095\/biolreprod55.5.935","volume":"55","author":"A Zini","year":"1996","unstructured":"Zini A, O\u2019Bryan MK, Magid MS, Schlegel PN (1996) Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epidydimis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death. Biol Reprod 55:935\u2013941","journal-title":"Biol Reprod"},{"key":"189_CR39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/01485019808988547","volume":"41","author":"A Zini","year":"1998","unstructured":"Zini A, Abitbol J, Girardi SK, Schulsinger D, Goldstein M, Schlegel PN (1998) Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia\u2013reperfusion injury to testis. Arch Androl 41:57\u201365","journal-title":"Arch Androl"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-007-0189-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-007-0189-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-007-0189-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:21:56Z","timestamp":1558624916000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-007-0189-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,8]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,8,3]]}},"alternative-id":["189"],"URL":"https:\/\/doi.org\/10.1007\/s00204-007-0189-2","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,8]]}}}