{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:56:32Z","timestamp":1790970992936,"version":"4.1.0"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00204-008-0314-x","type":"journal-article","created":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T12:06:18Z","timestamp":1211198778000},"page":"415-433","source":"Crossref","is-referenced-by-count":52,"title":["Family 1 uridine-5\u2032-diphosphate glucuronosyltransferases (UGT1A): from Gilbert\u2019s syndrome to genetic organization and variability"],"prefix":"10.1007","volume":"82","author":[{"given":"Christian P.","family":"Strassburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim O.","family":"Lankisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Manns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Ehmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,5,20]]},"reference":[{"key":"314_CR1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1023\/B:BREA.0000025419.26423.b8","volume":"85","author":"OJ Adegoke","year":"2004","unstructured":"Adegoke OJ, Shu XO, Gao YT, Cai Q, Breyer J, Smith J, Zheng W (2004) Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer. Breast Cancer Res Treat 85:239\u2013245","journal-title":"Breast Cancer Res Treat"},{"key":"314_CR2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00008571-199808000-00010","volume":"8","author":"Y Ando","year":"1998","unstructured":"Ando Y, Chida M, Nakayama K, Saka H, Kamataki T (1998a) The UGT1A1*28 allele is relatively rare in a Japanese population. Pharmacogenetics 8:357\u2013360","journal-title":"Pharmacogenetics"},{"key":"314_CR3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1023\/A:1008438109725","volume":"9","author":"Y Ando","year":"1998","unstructured":"Ando Y, Saka H, Asai G, Sugiura S, Shimokata K, Kamataki T (1998b) UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan. Ann Oncol 9:845\u2013847","journal-title":"Ann Oncol"},{"key":"314_CR4","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(95)90702-5","volume":"345","author":"S Aono","year":"1995","unstructured":"Aono S, Adachi Y, Uyama E, Yamada Y, Keino H, Nanno T, Koiwai O, Sato H (1995) Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert\u2019s syndrome. Lancet 345:958\u2013959","journal-title":"Lancet"},{"key":"314_CR5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1006\/bbrc.1993.2610","volume":"197","author":"S Aono","year":"1993","unstructured":"Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y, Yazawa T, Sato H, Koiwai O (1993) Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler\u2013Najjar syndrome type II. Biochem Biophys Res Commun 197:1239\u20131244","journal-title":"Biochem Biophys Res Commun"},{"key":"314_CR6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1203\/00006450-199406000-00002","volume":"35","author":"S Aono","year":"1994","unstructured":"Aono S, Yamada Y, Keino H, Sasaoka Y, Nakagawa T, Onishi S, Mimura S, Koiwai O, Sato H (1994) A new type of defect in the gene for bilirubin uridine 5\u2019-diphosphate- glucuronosyltransferase in a patient with Crigler\u2013Najjar syndrome type I. Pediatr Res 35:629\u2013632","journal-title":"Pediatr Res"},{"key":"314_CR7","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1172\/JCI104682","volume":"41","author":"IM Arias","year":"1962","unstructured":"Arias IM (1962) Chronic unconjugated hyperbilirubinemia without signs of overt hemolysis in adolescents and adults. J Clin Invest 41:2233\u20132245","journal-title":"J Clin Invest"},{"key":"314_CR8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00008571-200201000-00012","volume":"12","author":"C Balram","year":"2002","unstructured":"Balram C, Sabapathy K, Fei G, Khoo KS, Lee EJ (2002) Genetic polymorphisms of UDP-glucuronosyltransferase in Asians: UGT1A1*28 is a common allele in Indians. Pharmacogenetics 12:81\u201383","journal-title":"Pharmacogenetics"},{"key":"314_CR9","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","volume":"95","author":"E Beutler","year":"1998","unstructured":"Beutler E, Gelbart T, Demina A (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 95:8170\u20138174","journal-title":"Proc Natl Acad Sci USA"},{"key":"314_CR10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/10409239109081125","volume":"26","author":"KW Bock","year":"1991","unstructured":"Bock KW (1991) Roles of UDP-glucuronosyltransferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 26:129\u2013150","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"314_CR11","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","volume":"333","author":"PJ Bosma","year":"1995","unstructured":"Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP et al (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert\u2019s syndrome. N Engl J Med 333:1171\u20131175","journal-title":"N Engl J Med"},{"key":"314_CR12","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1096\/fasebj.6.10.1634050","volume":"6","author":"PJ Bosma","year":"1992","unstructured":"Bosma PJ, Chowdhury JR, Huang TJ, Lahiri P, Elferink RP, Van Es HH, Lederstein M, Whitington PF, Jansen PL, Chowdhury NR (1992a) Mechanisms of inherited deficiencies of multiple UDP- glucuronosyltransferase isoforms in two patients with Crigler\u2013Najjar syndrome, type I. FASEB J 6:2859\u20132863","journal-title":"FASEB J"},{"key":"314_CR13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/hep.1840150531","volume":"15","author":"PJ Bosma","year":"1992","unstructured":"Bosma PJ, Chowdhury NR, Goldhoorn BG, Hofker MH, Oude Elferink RP, Jansen PL, Chowdhury JR (1992b) Sequence of exons and the flanking regions of human bilirubin-UDP- glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler\u2013Najjar syndrome, type I. Hepatology 15:941\u2013947","journal-title":"Hepatology"},{"key":"314_CR14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0016-5085(93)90029-C","volume":"105","author":"PJ Bosma","year":"1993","unstructured":"Bosma PJ, Goldhoorn B, Oude Elferink RP, Sinaasappel M, Oostra BA, Jansen PL (1993) A mutation in bilirubin uridine 5\u2019-diphosphate-glucuronosyltransferase isoform 1 causing Crigler\u2013Najjar syndrome type II. Gastroenterology 105:216\u2013220","journal-title":"Gastroenterology"},{"key":"314_CR15","doi-asserted-by":"crossref","first-page":"17960","DOI":"10.1016\/S0021-9258(17)32403-1","volume":"269","author":"PJ Bosma","year":"1994","unstructured":"Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, Chowdhury NR, Jansen PL (1994) Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 269:17960\u201317964","journal-title":"J Biol Chem"},{"key":"314_CR16","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1158\/1055-9965.EPI-04-0682","volume":"14","author":"LM Butler","year":"2005","unstructured":"Butler LM, Duguay Y, Millikan RC, Sinha R, Gagne JF, Sandler RS, Guillemette C (2005) Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer. Cancer Epidemiol Biomarkers Prev 14:1626\u20131632","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"314_CR17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/FPC.0b013e32806d87a4","volume":"17","author":"B Caillier","year":"2007","unstructured":"Caillier B, Lepine J, Tojcic J, Menard V, Perusse L, Belanger A, Barbier O, Guillemette C (2007) A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3. Pharmacogenet Genomics 17:481\u2013495","journal-title":"Pharmacogenet Genomics"},{"key":"314_CR18","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1158\/1078-0432.1226.11.3","volume":"11","author":"LE Carlini","year":"2005","unstructured":"Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, Rogatko A, Wang H, Blanchard RL (2005) UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine\/irinotecan. Clin Cancer Res 11:1226\u20131236","journal-title":"Clin Cancer Res"},{"key":"314_CR19","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1440-1746.2005.04032.x","volume":"21","author":"K Chen","year":"2006","unstructured":"Chen K, Jin M, Zhu Y, Jiang Q, Yu W, Ma X, Yao K (2006) Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population. J Gastroenterol Hepatol 21:1036\u20131041","journal-title":"J Gastroenterol Hepatol"},{"key":"314_CR20","first-page":"52","volume":"45","author":"Z Cheng","year":"1998","unstructured":"Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, Mackenzie PI, Tephly TR (1998) Glucuronidation of catechol estrogens by expressed human UDP- glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci 45:52\u201357","journal-title":"Toxicol Sci"},{"issue":"3","key":"314_CR21","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1124\/mol.105.015891","volume":"69","author":"S Chouinard","year":"2006","unstructured":"Chouinard S, Tessier M, Vernouillet G, Gauthier S, Labrie F, Barbier O, Belanger A (2006) Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in the breast tissue. Mol Pharmacol 69(3):908\u2013920","journal-title":"Mol Pharmacol"},{"key":"314_CR22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/bbrc.1999.0453","volume":"260","author":"M Ciotti","year":"1999","unstructured":"Ciotti M, Basu N, Brangi M, Owens IS (1999) Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus. Biochem Biophys Res Commun 260:199\u2013202","journal-title":"Biochem Biophys Res Commun"},{"key":"314_CR23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bcmd.2005.09.002","volume":"36","author":"E Costa","year":"2006","unstructured":"Costa E, Vieira E, Martins M, Saraiva J, Cancela E, Costa M, Bauerle R, Freitas T, Carvalho JR, Santos-Silva E, Barbot J, Dos Santos R (2006) Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a clinical diagnosis of Gilbert and Crigler\u2013Najjar syndromes. Blood Cells Mol Dis 36:91\u201397","journal-title":"Blood Cells Mol Dis"},{"key":"314_CR24","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(00)02034-1","volume":"355","author":"JY Douillard","year":"2000","unstructured":"Douillard JY, Cunningham D, Roth AD, Navarro M, James RD, Karasek P, Jandik P, Iveson T, Carmichael J, Alakl M, Gruia G, Awad L, Rougier P (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 355:1041\u20131047","journal-title":"Lancet"},{"key":"314_CR25","first-page":"649","volume":"43","author":"T Ebner","year":"1993","unstructured":"Ebner T, Remmel RP, Burchell B (1993) Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol. Mol Pharmacol 43:649\u2013654","journal-title":"Mol Pharmacol"},{"key":"314_CR26","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/hep.20131","volume":"39","author":"U Ehmer","year":"2004","unstructured":"Ehmer U, Vogel A, Schutte JK, Krone B, Manns MP, Strassburg CP (2004) Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4. Hepatology 39:970\u2013977","journal-title":"Hepatology"},{"key":"314_CR27","first-page":"460","volume":"47","author":"M el Mouelhi","year":"1987","unstructured":"el Mouelhi M, Didolkar MS, Elias EG, Guengerich FP, Kauffman FC (1987) Hepatic drug-metabolizing enzymes in primary and secondary tumors of human liver. Cancer Res 47:460\u2013466","journal-title":"Cancer Res"},{"key":"314_CR28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jhep.2005.09.011","volume":"44","author":"E Ellis","year":"2006","unstructured":"Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg CP, Kylander C, Katsika D, Trauner M, Einarsson C, Marschall HU (2006) Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin. J Hepatol 44:243\u2013245","journal-title":"J Hepatol"},{"key":"314_CR29","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1074\/jbc.271.7.3952","volume":"271","author":"Y Emi","year":"1996","unstructured":"Emi Y, Ikushiro S, Iyanagi T (1996) Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J Biol Chem 271:3952\u20133958","journal-title":"J Biol Chem"},{"key":"314_CR30","unstructured":"Erichsen TJ, Ehmer U, Kalthoff S, Lankisch TO, M\u00fcller TM, Munzel PA, Manns MP, Strassburg CP (2008) Genetic variability of aryl hydrocarbon receptor (AhR)-mediated regulation of the human UDP glucuronosyltransferase (UGT) 1A4 gene. Toxicol Appl Pharmacol. doi: 10.1016\/j.taap.2008.02.02024 -->"},{"key":"314_CR31","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI117008","volume":"93","author":"LT Erps","year":"1994","unstructured":"Erps LT, Ritter JK, Hersh JH, Blossom D, Martin NC, Owens IS (1994) Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro. J Clin Invest 93:564\u2013570","journal-title":"J Clin Invest"},{"key":"314_CR32","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1349-7006.1989.tb01651.x","volume":"80","author":"H Esumi","year":"1989","unstructured":"Esumi H, Ohgaki H, Kohzen E, Takayama S, Sugimura T (1989) Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1- methyl-6-phenylimidazo[4, 5-b]pyridine. Jpn J Cancer Res 80:1176\u20131178","journal-title":"Jpn J Cancer Res"},{"key":"314_CR33","first-page":"1978","volume":"62","author":"JL Fang","year":"2002","unstructured":"Fang JL, Beland FA, Doerge DR, Wiener D, Guillemette C, Marques MM, Lazarus P (2002) Characterization of benzo(a) pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. Cancer Res 62:1978\u20131986","journal-title":"Cancer Res"},{"key":"314_CR34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1158\/1055-9965.EPI-03-0070","volume":"13","author":"JL Fang","year":"2004","unstructured":"Fang JL, Lazarus P (2004) Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a) pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant. Cancer Epidemiol Biomarkers Prev 13:102\u2013109","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"314_CR35","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3748\/wjg.v12.i14.2269","volume":"12","author":"S Farheen","year":"2006","unstructured":"Farheen S, Sengupta S, Santra A, Pal S, Dhali GK, Chakravorty M, Majumder PP, Chowdhury A (2006) Gilbert\u2019s syndrome: high frequency of the (TA) 7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene. World J Gastroenterol 12:2269\u20132275","journal-title":"World J Gastroenterol"},{"key":"314_CR36","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1124\/jpet.105.091900","volume":"315","author":"M Finel","year":"2005","unstructured":"Finel M, Li X, Gardner-Stephen D, Bratton S, Mackenzie PI, Radominska-Pandya A (2005) Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity. J Pharmacol Exp Ther 315:1143\u20131149","journal-title":"J Pharmacol Exp Ther"},{"key":"314_CR37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00448695","volume":"72","author":"G Fischer","year":"1985","unstructured":"Fischer G, Schauer A, Hartmann H, Bock KW (1985) Increased UDP-glucuronyltransferase in putative preneoplastic foci of human liver after long-term use of oral contraceptives. Naturwissenschaften 72:277\u2013278","journal-title":"Naturwissenschaften"},{"key":"314_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000076329","volume":"66","author":"G Folprecht","year":"2004","unstructured":"Folprecht G, Kohne CH (2004) The role of new agents in the treatment of colorectal cancer. Oncology 66:1\u201317","journal-title":"Oncology"},{"key":"314_CR39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2133\/dmpk.21.75","volume":"21","author":"K Fujita","year":"2006","unstructured":"Fujita K, Ando Y, Nagashima F, Yamamoto W, Endo H, Kodama K, Araki K, Miya T, Narabayashi M, Sasaki Y (2006) Novel single nucleotide polymorphism of UGT1A7 gene in Japanese. Drug Metab Pharmacokinet 21:75\u201378","journal-title":"Drug Metab Pharmacokinet"},{"key":"314_CR40","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/mol.62.3.608","volume":"62","author":"JF Gagne","year":"2002","unstructured":"Gagne JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C (2002) Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 62:608\u2013617","journal-title":"Mol Pharmacol"},{"issue":"1","key":"314_CR41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/dmd.106.012203","volume":"35","author":"DA Gardner-Stephen","year":"2007","unstructured":"Gardner-Stephen DA, Mackenzie PI (2007) Isolation of the UDP glucuronosyltransferase 1A3 and 1A4 proximal promoters and characterization of their dependence on the transcription factor hepatocyte nuclear factor 1 alpha. Drug Metab Dispos 35(1):116\u2013120","journal-title":"Drug Metab Dispos"},{"key":"314_CR42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/dmd.32.3.314","volume":"32","author":"A Ghosal","year":"2004","unstructured":"Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S (2004) Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia). Drug Metab Dispos 32:314\u2013320","journal-title":"Drug Metab Dispos"},{"key":"314_CR43","first-page":"241","volume":"21","author":"A Gilbert","year":"1901","unstructured":"Gilbert A, Lereboullet P (1901) La cholamae simple familiale. Sem Med 21:241\u2013248","journal-title":"Sem Med"},{"key":"314_CR44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00008571-200106000-00011","volume":"11","author":"QH Gong","year":"2001","unstructured":"Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC (2001) Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics 11:357\u2013368","journal-title":"Pharmacogenetics"},{"key":"314_CR45","first-page":"507","volume":"26","author":"MD Green","year":"1998","unstructured":"Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR (1998) Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 26:507\u2013512","journal-title":"Drug Metab Dispos"},{"key":"314_CR46","first-page":"356","volume":"24","author":"MD Green","year":"1996","unstructured":"Green MD, Tephly TR (1996) Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 24:356\u2013363","journal-title":"Drug Metab Dispos"},{"key":"314_CR47","first-page":"711","volume":"10","author":"C Guillemette","year":"2001","unstructured":"Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ (2001) Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiol Biomarkers Prev 10:711\u2013714","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"314_CR48","first-page":"950","volume":"60","author":"C Guillemette","year":"2000","unstructured":"Guillemette C, Millikan RC, Newman B, Housman DE (2000a) Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Cancer Res 60:950\u2013956","journal-title":"Cancer Res"},{"key":"314_CR49","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00008571-200010000-00006","volume":"10","author":"C Guillemette","year":"2000","unstructured":"Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE (2000b) Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 10:629\u2013644","journal-title":"Pharmacogenetics"},{"key":"314_CR50","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0090-9556(24)15257-9","volume":"27","author":"A Hiller","year":"1999","unstructured":"Hiller A, Nguyen N, Strassburg CP, Li Q, Jainta H, Pechstein B, Ruus P, Engel J, Tukey RH, Kronbach T (1999) Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos 27:605\u2013612","journal-title":"Drug Metab Dispos"},{"key":"314_CR51","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1006\/taap.1994.1166","volume":"127","author":"Z Hu","year":"1994","unstructured":"Hu Z, Wells PG (1994) Modulation of benzo[a]pyrene bioactivation by glucuronidation in lymphocytes and hepatic microsomes from rats with a hereditary deficiency in bilirubin UDP-glucuronosyltransferase. Toxicol Appl Pharmacol 127:306\u2013313","journal-title":"Toxicol Appl Pharmacol"},{"key":"314_CR52","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00008571-200212000-00006","volume":"12","author":"F Innocenti","year":"2002","unstructured":"Innocenti F, Grimsley C, Das S, Ramirez J, Cheng C, Kuttab-Boulos H, Ratain MJ, Di Rienzo A (2002) Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups. Pharmacogenetics 12:725\u2013733","journal-title":"Pharmacogenetics"},{"key":"314_CR53","first-page":"52","volume":"17","author":"F Innocenti","year":"2003","unstructured":"Innocenti F, Ratain MJ (2003) Irinotecan treatment in cancer patients with UGT1A1 polymorphisms. Oncology (Williston Park) 17:52\u201355","journal-title":"Oncology (Williston Park)"},{"key":"314_CR54","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1200\/JCO.2004.07.173","volume":"22","author":"F Innocenti","year":"2004","unstructured":"Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, Karrison T, Janisch L, Ramirez J, Rudin CM, Vokes EE, Ratain MJ (2004) Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22:1382\u20131388","journal-title":"J Clin Oncol"},{"key":"314_CR55","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1200\/JCO.2005.05.2464","volume":"24","author":"F Innocenti","year":"2006","unstructured":"Innocenti F, Vokes EE, Ratain MJ (2006) Irinogenetics: what is the right star? J Clin Oncol 24:2221\u20132224","journal-title":"J Clin Oncol"},{"key":"314_CR56","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10038-003-0119-y","volume":"49","author":"M Iwai","year":"2004","unstructured":"Iwai M, Maruo Y, Ito M, Yamamoto K, Sato H, Takeuchi Y (2004) Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity. J Hum Genet 49:123\u2013128","journal-title":"J Hum Genet"},{"key":"314_CR57","doi-asserted-by":"crossref","first-page":"24048","DOI":"10.1016\/S0021-9258(18)54390-8","volume":"266","author":"T Iyanagi","year":"1991","unstructured":"Iyanagi T (1991) Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). J Biol Chem 266:24048\u201324052","journal-title":"J Biol Chem"},{"key":"314_CR58","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI915","volume":"101","author":"L Iyer","year":"1998","unstructured":"Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, Ratain MJ (1998) Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 101:847\u2013854","journal-title":"J Clin Invest"},{"key":"314_CR59","first-page":"339","volume-title":"Xenobiotics and cancer: implications for chemical carcinogenesis and cancer chemotherapy","author":"FF Kadlubar","year":"1991","unstructured":"Kadlubar FF (1991) Carcinogenic aromatic amine metabolism and DNA adduct detection in humans. In: Ernster L, Esumi H, Fujii Z, Gelboin HV, Kato R, Sugimura T (eds) Xenobiotics and cancer: implications for chemical carcinogenesis and cancer chemotherapy. Japan Scientic Press, Tokyo, pp 339\u2013359"},{"key":"314_CR60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/dmd.104.002303","volume":"33","author":"N Kasai","year":"2005","unstructured":"Kasai N, Sakaki T, Shinkyo R, Ikushiro S, Iyanagi T, Ohta M, Inouye K (2005) Metabolism of 26,26,26,27,27,27-F6-1alpha,23S,25-trihydroxyvitamin D3 by human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 33:102\u2013107","journal-title":"Drug Metab Dispos"},{"key":"314_CR61","first-page":"4187","volume":"51","author":"Y Kawato","year":"1991","unstructured":"Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51:4187\u20134191","journal-title":"Cancer Res"},{"key":"314_CR62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/abbi.1996.0320","volume":"332","author":"CD King","year":"1996","unstructured":"King CD, Green MD, Rios GR, Coffman BL, Owens IS, Bishop WP, Tephly TR (1996) The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1. Arch Biochem Biophys 332:92\u2013100","journal-title":"Arch Biochem Biophys"},{"key":"314_CR63","first-page":"251","volume":"25","author":"CD King","year":"1997","unstructured":"King CD, Rios GR, Green MD, MacKenzie PI, Tephly TR (1997) Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds. Drug Metab Dispos 25:251\u2013255","journal-title":"Drug Metab Dispos"},{"key":"314_CR64","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0006-2952(03)00074-1","volume":"65","author":"C Kohle","year":"2003","unstructured":"Kohle C, Mohrle B, Munzel PA, Schwab M, Wernet D, Badary OA, Bock KW (2003) Frequent co-occurrence of the TATA box mutation associated with Gilbert\u2019s syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochem Pharmacol 65:1521\u20131527","journal-title":"Biochem Pharmacol"},{"key":"314_CR65","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1349-7006.2007.00693.x","volume":"99","author":"SY Kong","year":"2008","unstructured":"Kong SY, Ki CS, Yoo BC, Kim JW (2008) UGT1A7 haplotype is associated with an increased risk of hepatocellular carcinoma in hepatitis B carriers. Cancer Sci 99:340\u2013344","journal-title":"Cancer Sci"},{"key":"314_CR66","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1124\/dmd.104.002527","volume":"33","author":"GE Kuehl","year":"2005","unstructured":"Kuehl GE, Lampe JW, Potter JD, Bigler J (2005) Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos 33:1027\u20131035","journal-title":"Drug Metab Dispos"},{"key":"314_CR67","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/(SICI)1097-0215(20000215)85:4<498::AID-IJC9>3.0.CO;2-F","volume":"85","author":"H Kuper","year":"2000","unstructured":"Kuper H, Tzonou A, Kaklamani E, Hsieh CC, Lagiou P, Adami HO, Trichopoulos D, Stuver SO (2000) Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 85:498\u2013502","journal-title":"Int J Cancer"},{"key":"314_CR68","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00008469-199512000-00005","volume":"4","author":"C La Vecchia","year":"1995","unstructured":"La Vecchia C, D\u2019Avanzo B., Airoldi L, Braga C, Decarli A (1995) Nitrosamine intake and gastric cancer risk. Eur J Cancer Prev 4:469\u2013474","journal-title":"Eur J Cancer Prev"},{"key":"314_CR69","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/BF00206965","volume":"94","author":"P Labrune","year":"1994","unstructured":"Labrune P, Myara A, Hadchouel M, Ronchi F, Bernard O, Trivin F, Chowdhury NR, Chowdhury JR, Munnich A, Odievre M (1994) Genetic heterogeneity of Crigler\u2013Najjar syndrome type I: a study of 14 cases. Hum Genet 94:693\u2013697","journal-title":"Hum Genet"},{"key":"314_CR70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00008571-199906000-00009","volume":"9","author":"JW Lampe","year":"1999","unstructured":"Lampe JW, Bigler J, Horner NK, Potter JD (1999) UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations. Pharmacogenetics 9:341\u2013349","journal-title":"Pharmacogenetics"},{"key":"314_CR71","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/hep.21361","volume":"44","author":"TO Lankisch","year":"2006","unstructured":"Lankisch TO, Moebius U, Wehmeier M, Behrens G, Manns MP, Schmidt RE, Strassburg CP (2006) Gilbert\u2019s disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. Hepatology 44:1324\u20131332","journal-title":"Hepatology"},{"key":"314_CR72","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1158\/1055-9965.EPI-07-2517","volume":"17","author":"TO Lankisch","year":"2008","unstructured":"Lankisch TO, Schulz C, Zwingers T, Erichsen TJ, Manns MP, Heinemann V, Strassburg CP (2008) Gilbert\u2019s Syndrome and Irinotecan Toxicity: Combination with UDP-Glucuronosyltransferase 1A7 Variants Increases Risk. Cancer Epidemiol Biomarkers Prev 17:695\u2013701","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"314_CR73","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1124\/mol.104.007146","volume":"67","author":"TO Lankisch","year":"2005","unstructured":"Lankisch TO, Vogel A, Eilermann S, Fiebeler A, Krone B, Barut A, Manns MP, Strassburg CP (2005) Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol 67:1732\u20131739","journal-title":"Mol Pharmacol"},{"key":"314_CR74","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008571-199708000-00001","volume":"7","author":"PI Mackenzie","year":"1997","unstructured":"Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (1997) The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255\u2013269","journal-title":"Pharmacogenetics"},{"key":"314_CR75","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003088-197904030-00004","volume":"4","author":"AF Macklon","year":"1979","unstructured":"Macklon AF, Savage RL, Rawlins MD (1979) Gilbert\u2019s syndrome and drug metabolism. Clin Pharmacokinet 4:223\u2013232","journal-title":"Clin Pharmacokinet"},{"key":"314_CR76","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/sj.tpj.6500351","volume":"6","author":"ML Maitland","year":"2006","unstructured":"Maitland ML, Grimsley C, Kuttab-Boulos H, Witonsky D, Kasza KE, Yang L, Roe BA, Di Rienzo A (2006) Comparative genomics analysis of human sequence variation in the UGT1A gene cluster. Pharmacogenomics J 6:52\u201362","journal-title":"Pharmacogenomics J"},{"key":"314_CR77","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/tx049898m","volume":"17","author":"MA Malfatti","year":"2004","unstructured":"Malfatti MA, Felton JS (2004) Human UDP-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro. Chem Res Toxicol 17:1137\u20131144","journal-title":"Chem Res Toxicol"},{"key":"314_CR78","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/sj.bjc.6602042","volume":"91","author":"E Marcuello","year":"2004","unstructured":"Marcuello E, Altes A, Menoyo A, Del Rio E, Gomez-Pardo M, Baiget M (2004) UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer. Br J Cancer 91:678\u2013682","journal-title":"Br J Cancer"},{"key":"314_CR79","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0016-5085(76)80151-5","volume":"70","author":"JF Martin","year":"1976","unstructured":"Martin JF, Vierling JM, Wolkoff AW, Scharschmidt BF, Vergalla J, Waggoner JG, Berk PD (1976) Abnormal hepatic transport of indocyanine green in Gilbert\u2019s syndrome. Gastroenterology 70:385\u2013391","journal-title":"Gastroenterology"},{"key":"314_CR80","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/geno.1993.1451","volume":"18","author":"N Moghrabi","year":"1993","unstructured":"Moghrabi N, Clarke DJ, Boxer M, Burchell B (1993a) Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler\u2013Najjar syndrome type 2. Genomics 18:171\u2013173","journal-title":"Genomics"},{"key":"314_CR81","first-page":"722","volume":"53","author":"N Moghrabi","year":"1993","unstructured":"Moghrabi N, Clarke DJ, Burchell B, Boxer M (1993b) Cosegregation of intragenic markers with a novel mutation that causes Crigler\u2013Najjar syndrome type I: implication in carrier detection and prenatal diagnosis. Am J Hum Genet 53:722\u2013729","journal-title":"Am J Hum Genet"},{"key":"314_CR82","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1006\/bbrc.1996.1251","volume":"225","author":"B Mojarrabi","year":"1996","unstructured":"Mojarrabi B, Butler R, Mackenzie PI (1996) cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3. Biochem Biophys Res Commun 225:785\u2013790","journal-title":"Biochem Biophys Res Commun"},{"key":"314_CR83","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","volume":"347","author":"G Monaghan","year":"1996","unstructured":"Monaghan G, Ryan M, Seddon R, Hume R, Burchell B (1996) Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert\u2019s syndrome. Lancet 347:578\u2013581","journal-title":"Lancet"},{"key":"314_CR84","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1124\/dmd.104.002576","volume":"33","author":"A Mori","year":"2005","unstructured":"Mori A, Maruo Y, Iwai M, Sato H, Takeuchi Y (2005) UDP-glucuronosyltransferase 1A4 polymorphisms in a Japanese population and kinetics of clozapine glucuronidation. Drug Metab Dispos 33:672\u2013675","journal-title":"Drug Metab Dispos"},{"key":"314_CR85","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/carcin\/20.6.1107","volume":"20","author":"SA Nowell","year":"1999","unstructured":"Nowell SA, Massengill JS, Williams S, Radominska-Pandya A, Tephly TR, Cheng Z, Strassburg CP, Tukey RH, MacLeod SL, Lang NP, Kadlubar FF (1999) Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4, 5- b]pyridine by human microsomal UDP-glucuronosyltransferases: identification of specific UGT1A family isoforms involved. Carcinogenesis 20:1107\u20131114","journal-title":"Carcinogenesis"},{"key":"314_CR86","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/S0016-5085(03)00294-4","volume":"124","author":"J Ockenga","year":"2003","unstructured":"Ockenga J, Vogel A, Teich N, Keim V, Manns MP, Strassburg CP (2003) UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Gastroenterology 124:1802\u20131808","journal-title":"Gastroenterology"},{"key":"314_CR87","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1124\/dmd.105.007633","volume":"34","author":"BW Ogilvie","year":"2006","unstructured":"Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A (2006) Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of cyp2c8: implications for drug-drug interactions. Drug Metab Dispos 34:191\u2013197","journal-title":"Drug Metab Dispos"},{"key":"314_CR88","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.3748\/wjg.v12.i39.6343","volume":"12","author":"A Piepoli","year":"2006","unstructured":"Piepoli A, Gentile A, Valvano MR, Barana D, Oliani C, Cotugno R, Quitadamo M, Andriulli A, Perri F (2006) Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. World J Gastroenterol 12:6343\u20136348","journal-title":"World J Gastroenterol"},{"key":"314_CR89","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/dmd.30.5.505","volume":"30","author":"T Prueksaritanont","year":"2002","unstructured":"Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA (2002) Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos 30:505\u2013512","journal-title":"Drug Metab Dispos"},{"key":"314_CR90","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1016\/S0021-9258(19)50724-4","volume":"267","author":"JK Ritter","year":"1992","unstructured":"Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (1992a) A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257\u20133261","journal-title":"J Biol Chem"},{"key":"314_CR91","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0021-9258(17)35280-8","volume":"266","author":"JK Ritter","year":"1991","unstructured":"Ritter JK, Crawford JM, Owens IS (1991) Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266:1043\u20131047","journal-title":"J Biol Chem"},{"key":"314_CR92","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/hep.510300205","volume":"30","author":"JK Ritter","year":"1999","unstructured":"Ritter JK, Kessler FK, Thompson MT, Grove AD, Auyeung DJ, Fisher RA (1999) Expression and inducibility of the human bilirubin UDP- glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: evidence for both genetic and environmental influences. Hepatology 30:476\u2013484","journal-title":"Hepatology"},{"key":"314_CR93","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1172\/JCI115829","volume":"90","author":"JK Ritter","year":"1992","unstructured":"Ritter JK, Yeatman MT, Ferreira P, Owens IS (1992b) Identification of a genetic alteration in the code for bilirubin UDP- glucuronosyltransferase in the UGT1 gene complex of a Crigler\u2013Najjar type I patient. J Clin Invest 90:150\u2013155","journal-title":"J Clin Invest"},{"key":"314_CR94","doi-asserted-by":"crossref","first-page":"23573","DOI":"10.1016\/S0021-9258(19)49501-X","volume":"268","author":"JK Ritter","year":"1993","unstructured":"Ritter JK, Yeatman MT, Kaiser C, Gridelli B, Owens IS (1993) A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler\u2013Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase. J Biol Chem 268:23573\u201323579","journal-title":"J Biol Chem"},{"key":"314_CR95","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1086\/466531","volume":"192","author":"M Rotger","year":"2005","unstructured":"Rotger M, Taffe P, Bleiber G, Gunthard HF, Furrer H, Vernazza P, Drechsler H, Bernasconi E, Rickenbach M, Telenti A (2005) Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. J Infect Dis 192:1381\u20131386","journal-title":"J Infect Dis"},{"key":"314_CR96","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1158\/1078-0432.CCR-03-0548","volume":"10","author":"E Rouits","year":"2004","unstructured":"Rouits E, Boisdron-Celle M, Dumont A, Guerin O, Morel A, Gamelin E (2004) Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients. Clin Cancer Res 10:5151\u20135159","journal-title":"Clin Cancer Res"},{"key":"314_CR97","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2133\/dmpk.20.144","volume":"20","author":"M Saeki","year":"2005","unstructured":"Saeki M, Saito Y, Jinno H, Sai K, Hachisuka A, Kaniwa N, Ozawa S, Kawamoto M, Kamatani N, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Sawada J (2005a) Genetic variations and haplotypes of UGT1A4 in a Japanese population. Drug Metab Pharmacokinet 20:144\u2013151","journal-title":"Drug Metab Pharmacokinet"},{"key":"314_CR98","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2133\/dmpk.20.85","volume":"20","author":"M Saeki","year":"2005","unstructured":"Saeki M, Saito Y, Jinno H, Sai K, Kaniwa N, Ozawa S, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kamatani N, Sawada J (2005b) Genetic polymorphisms of UGT1A6 in a Japanese population. Drug Metab Pharmacokinet 20:85\u201390","journal-title":"Drug Metab Pharmacokinet"},{"key":"314_CR99","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.tpj.6500335","volume":"6","author":"M Saeki","year":"2006","unstructured":"Saeki M, Saito Y, Jinno H, Sai K, Ozawa S, Kurose K, Kaniwa N, Komamura K, Kotake T, Morishita H, Kamakura S, Kitakaze M, Tomoike H, Shirao K, Tamura T, Yamamoto N, Kunitoh H, Hamaguchi T, Yoshida T, Kubota K, Ohtsu A, Muto M, Minami H, Saijo N, Kamatani N, Sawada JI (2006) Haplotype structures of the UGT1A gene complex in a Japanese population. Pharmacogenomics J 6:63\u201375","journal-title":"Pharmacogenomics J"},{"key":"314_CR100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.clpt.2004.01.010","volume":"75","author":"K Sai","year":"2004","unstructured":"Sai K, Saeki M, Saito Y, Ozawa S, Katori N, Jinno H, Hasegawa R, Kaniwa N, Sawada J, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kitamura Y, Kamatani N, Minami H, Ohtsu A, Shirao K, Yoshida T, Saijo N (2004) UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer. Clin Pharmacol Ther 75:501\u2013515","journal-title":"Clin Pharmacol Ther"},{"key":"314_CR101","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1172\/JCI117604","volume":"94","author":"J Seppen","year":"1994","unstructured":"Seppen J, Bosma PJ, Goldhoorn BG, Bakker CT, Chowdhury JR, Chowdhury NR, Jansen PL, Oude Elferink RP (1994) Discrimination between Crigler\u2013Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. J Clin Invest 94:2385\u20132391","journal-title":"J Clin Invest"},{"key":"314_CR102","doi-asserted-by":"crossref","first-page":"R488","DOI":"10.1186\/bcr818","volume":"6","author":"R Sparks","year":"2004","unstructured":"Sparks R, Ulrich CM, Bigler J, Tworoger SS, Yasui Y, Rajan KB, Porter P, Stanczyk FZ, Ballard-Barbash R, Yuan X, Lin MG, McVarish L, Aiello EJ, McTiernan A (2004) UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Breast Cancer Res 6:R488\u2013498","journal-title":"Breast Cancer Res"},{"key":"314_CR103","doi-asserted-by":"crossref","first-page":"36164","DOI":"10.1074\/jbc.M002180200","volume":"275","author":"CP Strassburg","year":"2000","unstructured":"Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP (2000) Polymorphic gene expression and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 275:36164\u201336171","journal-title":"J Biol Chem"},{"key":"314_CR104","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0168-8278(00)80285-8","volume":"33","author":"CP Strassburg","year":"2000","unstructured":"Strassburg CP, Manns MP (2000) Jaundice, genes and promoters. J Hepatology 33:476\u2013479","journal-title":"J Hepatology"},{"key":"314_CR105","first-page":"2979","volume":"57","author":"CP Strassburg","year":"1997","unstructured":"Strassburg CP, Manns MP, Tukey RH (1997a) Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res 57:2979\u20132985","journal-title":"Cancer Res"},{"key":"314_CR106","doi-asserted-by":"crossref","first-page":"8719","DOI":"10.1074\/jbc.273.15.8719","volume":"273","author":"CP Strassburg","year":"1998","unstructured":"Strassburg CP, Manns MP, Tukey RH (1998a) Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 273:8719\u20138726","journal-title":"J Biol Chem"},{"key":"314_CR107","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0026-895X(24)13065-9","volume":"54","author":"CP Strassburg","year":"1998","unstructured":"Strassburg CP, Nguyen N, Manns MP, Tukey RH (1998b) Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium. Mol Pharmacol 54:647\u2013654","journal-title":"Mol Pharmacol"},{"key":"314_CR108","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0016-5085(99)70239-8","volume":"116","author":"CP Strassburg","year":"1999","unstructured":"Strassburg CP, Nguyen N, Manns MP, Tukey RH (1999a) UDP-glucuronosyltransferase activity in human liver and colon. Gastroenterology 116:149\u2013160","journal-title":"Gastroenterology"},{"key":"314_CR109","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1124\/mol.52.2.212","volume":"52","author":"CP Strassburg","year":"1997","unstructured":"Strassburg CP, Oldhafer K, Manns MP, Tukey RH (1997b) Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol Pharmacol 52:212\u2013220","journal-title":"Mol Pharmacol"},{"key":"314_CR110","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.50.2.259","volume":"50","author":"CP Strassburg","year":"2002","unstructured":"Strassburg CP, Strassburg A, Kneip S, Barut A, Tukey RH, Rodeck B, Manns MP (2002a) Developmental aspects of human hepatic drug glucuronidation in young children and adults. Gut 50:259\u2013265","journal-title":"Gut"},{"key":"314_CR111","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj3380489","volume":"338","author":"CP Strassburg","year":"1999","unstructured":"Strassburg CP, Strassburg A, Nguyen N, Li Q, Manns MP, Tukey RH (1999b) Regulation and function of family 1 and family 2 UDP- glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. Biochem J 338:489\u2013498","journal-title":"Biochem J"},{"key":"314_CR112","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/gut.50.6.851","volume":"50","author":"CP Strassburg","year":"2002","unstructured":"Strassburg CP, Vogel A, Kneip S, Tukey RH, Manns MP (2002b) Polymorphisms of the UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer. Gut 50:851\u2013856","journal-title":"Gut"},{"key":"314_CR113","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1471-2407-7-214","volume":"7","author":"I Stucker","year":"2007","unstructured":"Stucker I, Loriot MA, N\u2019Koutchou G., Cenee S, Bodin L, Mulot C, Gelu-Simeon M, Pelletier L, Bronowicki JP, Degos F, Beaune P, Laurent-Puig P, Hemon D, Trinchet JC, Pelletier G (2007) UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? BMC Cancer 7:214","journal-title":"BMC Cancer"},{"key":"314_CR114","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","volume":"33","author":"J Sugatani","year":"2001","unstructured":"Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232\u20131238","journal-title":"Hepatology"},{"key":"314_CR115","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/bbrc.2002.6683","volume":"292","author":"J Sugatani","year":"2002","unstructured":"Sugatani J, Yamakawa K, Yoshinari K, Machida T, Takagi H, Mori M, Kakizaki S, Sueyoshi T, Negishi M, Miwa M (2002) Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem Biophys Res Commun 292:492\u2013497","journal-title":"Biochem Biophys Res Commun"},{"key":"314_CR116","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1186\/bcr1539","volume":"8","author":"D Sun","year":"2006","unstructured":"Sun D, Chen G, Dellinger RW, Duncan K, Fang JL, Lazarus P (2006) Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. Breast Cancer Res 8:R50","journal-title":"Breast Cancer Res"},{"key":"314_CR117","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1442-200X.2002.t01-1-01577.x","volume":"44","author":"R Sutomo","year":"2002","unstructured":"Sutomo R, Laosombat V, Sadewa AH, Yokoyama N, Nakamura H, Matsuo M, Nishio H (2002) Novel missense mutation of the UGT1A1 gene in Thai siblings with Gilbert\u2019s syndrome. Pediatr Int 44:427\u2013432","journal-title":"Pediatr Int"},{"issue":"1","key":"314_CR118","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1124\/jpet.106.110924","volume":"320","author":"MN Tallman","year":"2007","unstructured":"Tallman MN, Miles K, Kessler F, Neilson J, Tian X, Ritter JK, Smith PC (2007) The contribution of intestinal UDP-glucuronosyltrasferases in modulating 7-ethyl-10-hydroxy-camptothecin (Sn-38)-induced gastrointestinal toxicity in rats. J Pharmacol Exp Ther 320(1):29\u201337","journal-title":"J Pharmacol Exp Ther"},{"key":"314_CR119","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.3748\/wjg.v11.i21.3250","volume":"11","author":"KS Tang","year":"2005","unstructured":"Tang KS, Chiu HF, Chen HH, Eng HL, Tsai CJ, Teng HC, Huang CS (2005) Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes. World J Gastroenterol 11:3250\u20133254","journal-title":"World J Gastroenterol"},{"key":"314_CR120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/sj.tpj.6500443","volume":"8","author":"RH te Morsche","year":"2008","unstructured":"te Morsche RH, Drenth JP, Truninger K, Schulz HU, Kage A, Landt O, Verlaan M, Rosendahl J, Macek M Jr., Jansen JB, Witt H (2008) UGT1A7 polymorphisms in chronic pancreatitis: an example of genotyping pitfalls. Pharmacogenomics J 8:34\u201341","journal-title":"Pharmacogenomics J"},{"key":"314_CR121","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/humu.9432","volume":"27","author":"SS Thomas","year":"2006","unstructured":"Thomas SS, Li SS, Lampe JW, Potter JD, Bigler J (2006) Genetic variability, haplotypes, and htSNPs for exons 1 at the human UGT1A locus. Hum Mutat 27:717","journal-title":"Hum Mutat"},{"key":"314_CR122","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0300-483X(02)00513-9","volume":"183","author":"AR Tricker","year":"2003","unstructured":"Tricker AR (2003) Nicotine metabolism, human drug metabolism polymorphisms, and smoking behaviour. Toxicology 183:151\u2013173","journal-title":"Toxicology"},{"key":"314_CR123","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/hep.21362","volume":"44","author":"J Trottier","year":"2006","unstructured":"Trottier J, Verreault M, Grepper S, Monte D, Belanger J, Kaeding J, Caron P, Inaba TT, Barbier O (2006) Human UDP-glucuronosyltransferase (UGT) 1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 44:1158\u20131170","journal-title":"Hepatology"},{"key":"314_CR124","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/j.1572-0241.2005.41857.x","volume":"100","author":"CS Tseng","year":"2005","unstructured":"Tseng CS, Tang KS, Lo HW, Ker CG, Teng HC, Huang CS (2005) UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. Am J Gastroenterol 100:1758\u20131763","journal-title":"Am J Gastroenterol"},{"key":"314_CR125","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","volume":"40","author":"RH Tukey","year":"2000","unstructured":"Tukey RH, Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581\u2013616","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"314_CR126","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/mol.59.3.405","volume":"59","author":"RH Tukey","year":"2001","unstructured":"Tukey RH, Strassburg CP (2001) Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 59:405\u2013414","journal-title":"Mol Pharmacol"},{"key":"314_CR127","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1124\/mol.62.3.446","volume":"62","author":"RH Tukey","year":"2002","unstructured":"Tukey RH, Strassburg CP, Mackenzie PI (2002) Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicity. Mol Pharmacol 62:446\u2013450","journal-title":"Mol Pharmacol"},{"key":"314_CR128","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/FPC.0b013e328256b1b6","volume":"17","author":"W Udomuksorn","year":"2007","unstructured":"Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO (2007) Influence of mutations associated with Gilbert and Crigler\u2013Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics 17:1017\u20131029","journal-title":"Pharmacogenet Genomics"},{"issue":"5","key":"314_CR129","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bcp.2005.11.014","volume":"71","author":"T Usui","year":"2005","unstructured":"Usui T, Kuno T, Ueyama H, Ohkubo I, Mizutani T (2005) Proximal HNF1 element is essential for the induction of human UDP-glucuronosyltransferase 1A1 by glucocorticoid receptor. Biochem Pharmacol 71(5):693\u2013701","journal-title":"Biochem Pharmacol"},{"key":"314_CR130","first-page":"19","volume":"19","author":"EM Logt Van Der","year":"2004","unstructured":"Van Der Logt EM, Bergevoet SM, Roelofs HM, Van Hooijdonk Z, te Morsche RH, Wobbes T, De Kok JB, Nagengast FM, Peters WH (2004) Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk. Carcinogenesis 19:19","journal-title":"Carcinogenesis"},{"key":"314_CR131","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1136\/jmg.2005.032599","volume":"42","author":"M Verlaan","year":"2005","unstructured":"Verlaan M, Drenth JP, Truninger K, Koudova M, Schulz HU, Bargetzi M, Kunzli B, Friess H, Cerny M, Kage A, Landt O, te Morsche RH, Rosendahl J, Luck W, Nickel R, Halangk J, Becker M, Macek M Jr, Jansen JB, Witt H (2005) Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases. J Med Genet 42:e62","journal-title":"J Med Genet"},{"key":"314_CR132","first-page":"1045","volume":"55","author":"DS Vienneau","year":"1995","unstructured":"Vienneau DS, DeBoni U, Wells PG (1995) Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a) pyrene and benzo(e) pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts. Cancer Res 55:1045\u20131051","journal-title":"Cancer Res"},{"key":"314_CR133","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1124\/jpet.103.054072","volume":"307","author":"L Villeneuve","year":"2003","unstructured":"Villeneuve L, Girard H, Fortier LC, Gagne JF, Guillemette C (2003) Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 307:117\u2013128","journal-title":"J Pharmacol Exp Ther"},{"key":"314_CR134","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1053\/gast.2001.28655","volume":"121","author":"A Vogel","year":"2001","unstructured":"Vogel A, Kneip S, Barut S, Ehmer U, Tukey RH, Manns MP, Strassburg CP (2001) Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-Glucuronosyltransferase UGT1A7 gene. Gastroenterology 121:1136\u20131144","journal-title":"Gastroenterology"},{"key":"314_CR135","first-page":"2092s","volume":"52","author":"K Wakabayashi","year":"1992","unstructured":"Wakabayashi K, Nagao M, Esumi H, Sugimura T (1992) Food-derived mutagens and carcinogens. Cancer Res 52:2092s\u20132098s","journal-title":"Cancer Res"},{"key":"314_CR136","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1158\/1078-0432.CCR-1187-3","volume":"10","author":"Y Wang","year":"2004","unstructured":"Wang Y, Kato N, Hoshida Y, Otsuka M, Taniguchi H, Moriyama M, Shiina S, Kawabe T, Ito YM, Omata M (2004) UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. Clin Cancer Res 10:2441\u20132446","journal-title":"Clin Cancer Res"},{"key":"314_CR137","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1124\/dmd.32.1.72","volume":"32","author":"D Wiener","year":"2004","unstructured":"Wiener D, Doerge DR, Fang JL, Upadhyaya P, Lazarus P (2004) Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. Drug Metab Dispos 32:72\u201379","journal-title":"Drug Metab Dispos"},{"key":"314_CR138","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1124\/dmd.106.009274","volume":"34","author":"Z Yan","year":"2006","unstructured":"Yan Z, Caldwell GW, Gauthier D, Leo GC, Mei J, Ho CY, Jones WJ, Masucci JA, Tuman RW, Galemmo RA Jr, Johnson DL (2006) N-glucuronidation of the platelet-derived growth factor receptor tyrosine kinase inhibitor 6, 7-(dimethoxy-2, 4-dihydroindeno[1, 2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-ami ne by human UDP-glucuronosyltransferases. Drug Metab Dispos 34:748\u2013755","journal-title":"Drug Metab Dispos"},{"key":"314_CR139","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1074\/jbc.M610790200","volume":"282","author":"MF Yueh","year":"2007","unstructured":"Yueh MF, Tukey RH (2007) Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice. J Biol Chem 282:8749\u20138758","journal-title":"J Biol Chem"},{"key":"314_CR140","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1124\/dmd.105.005447","volume":"33","author":"D Zhang","year":"2005","unstructured":"Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG (2005) In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos 33:1729\u20131739","journal-title":"Drug Metab Dispos"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-008-0314-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-008-0314-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-008-0314-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T10:18:41Z","timestamp":1738232321000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-008-0314-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,20]]},"references-count":140,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["314"],"URL":"https:\/\/doi.org\/10.1007\/s00204-008-0314-x","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,20]]}}}