{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:31:38Z","timestamp":1785828698920,"version":"3.56.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T00:00:00Z","timestamp":1288137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s00204-010-0611-z","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T03:42:30Z","timestamp":1288064550000},"page":"653-661","source":"Crossref","is-referenced-by-count":57,"title":["Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner"],"prefix":"10.1007","volume":"85","author":[{"given":"Keiko","family":"Nohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyo","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,27]]},"reference":[{"key":"611_CR1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.taap.2008.12.004","volume":"239","author":"U Bardullas","year":"2009","unstructured":"Bardullas U, Lim\u00f3n-Pacheco JH, Giordano M, Carrizales L, Mendoza-Trejo MS, Rodr\u00edguez VM (2009) Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice. Toxicol Appl Pharmacol 239:169\u2013177","journal-title":"Toxicol Appl Pharmacol"},{"key":"611_CR2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","volume":"128","author":"BE Bernstein","year":"2007","unstructured":"Bernstein BE, Meissner A, Lander ES (2007) The mammalian epigenome. Cell 128:669\u2013681","journal-title":"Cell"},{"key":"611_CR3","first-page":"5470","volume":"50","author":"CJ Chen","year":"1990","unstructured":"Chen CJ, Wang CJ (1990) Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res 50:5470\u20135474","journal-title":"Cancer Res"},{"key":"611_CR4","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1093\/carcin\/bgh161","volume":"25","author":"H Chen","year":"2004","unstructured":"Chen H, Li S, Liu J, Diwan BA, Barrett JC, Waalkes MP (2004) Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis 25:1779\u20131786","journal-title":"Carcinogenesis"},{"key":"611_CR5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.str.2008.01.004","volume":"16","author":"X Cheng","year":"2008","unstructured":"Cheng X, Blumenthal RM (2008) Mammalian DNA methyltransferases: a structural perspective. Structure\u00a016:341\u2013350","journal-title":"Structure"},{"key":"611_CR6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1349-7006.2002.tb01250.x","volume":"93","author":"A Denda","year":"2002","unstructured":"Denda A, Kitayama W, Kishida H, Murata N, Tsutsumi M, Tsujiuchi T, Nakae D, Konishi Y (2002) Development of hepatocellular adenomas and carcinomas associated with fibrosis in C57BL\/6J male mice given a choline-deficient, L-amino acid-defined diet. Jpn J Cancer Res 93:125\u2013132","journal-title":"Jpn J Cancer Res"},{"key":"611_CR7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2006.03.033","volume":"125","author":"M Doi","year":"2006","unstructured":"Doi M, Hirayama J, Sassone-Corsi P (2006) Circadian regulator CLOCK is a histone acetyltransferase. Cell 125:497\u2013508","journal-title":"Cell"},{"key":"611_CR8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrfmmm.2006.05.029","volume":"600","author":"R Feil","year":"2006","unstructured":"Feil R (2006) Environmental and nutritional effects on the epigenetic regulation of genes. Mutat Res 600:46\u201357","journal-title":"Mutat Res"},{"key":"611_CR9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature05919","volume":"447","author":"AP Feinberg","year":"2007","unstructured":"Feinberg AP (2007) Phenotypic plasticity and the epigenetics of human disease. Nature 447:433\u2013440","journal-title":"Nature"},{"key":"611_CR10","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1021\/ac020050h","volume":"74","author":"S Friso","year":"2002","unstructured":"Friso S, Choi SW, Dolnikowski GG, Selhub J (2002) A method to assess genomic DNA methylation using high-performance liquid chromatography\/electrospray ionization mass spectrometry. Anal Chem 74:4526\u20134531","journal-title":"Anal Chem"},{"key":"611_CR11","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jn\/136.6.1522","volume":"136","author":"K Ghoshal","year":"2006","unstructured":"Ghoshal K, Li X, Datta J, Bai S, Pogribny I, Pogribny M, Huang Y, Young D, Jacob ST (2006) A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr 136:1522\u20131527","journal-title":"J Nutr"},{"key":"611_CR12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00204-010-0575-z","volume":"84","author":"K Golka","year":"2010","unstructured":"Golka K, Hengstler JG, Marchan R, Bolt HM (2010) Severe arsenic poisoning: one of the largest man-made catostrophies. Arch Toxicol 84:583\u2013584","journal-title":"Arch Toxicol"},{"key":"611_CR13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mrfmmm.2008.08.006","volume":"647","author":"S Gopalakrishnan","year":"2008","unstructured":"Gopalakrishnan S, Van Emburgh BO, Robertson KD (2008) DNA methylation in development and human disease. Mutat Res 647:30\u201338","journal-title":"Mutat Res"},{"key":"611_CR14","doi-asserted-by":"crossref","first-page":"3740S","DOI":"10.1093\/jn\/133.11.3740S","volume":"133","author":"SJ James","year":"2003","unstructured":"James SJ, Pogribny IP, Pogribna M, Miller BJ, Jernigan S, Melnyk S (2003) Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate\/methyl-deficient rat model of hepatocarcinogenesis. J Nutr 133:3740S\u20133747S","journal-title":"J Nutr"},{"key":"611_CR15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/toxsci\/kfn120","volume":"105","author":"J Liu","year":"2008","unstructured":"Liu J, Waalkes MP (2008) Liver is a target of arsenic carcinogenesis. Toxicol Sci 105:24\u201332","journal-title":"Toxicol Sci"},{"key":"611_CR16","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1042\/BST20060330","volume":"34","author":"WAM Loenen","year":"2006","unstructured":"Loenen WAM (2006) S-adenosylmethionine: jack of all trades and master of everything? Biochem Soc Trans 34:330\u2013333","journal-title":"Biochem Soc Trans"},{"key":"611_CR17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0013-9351(02)00081-6","volume":"92","author":"CA Loffredo","year":"2003","unstructured":"Loffredo CA, Aposhian HV, Cebrian ME, Yamauchi H, Silbergeld EK (2003) Variability in human metabolism of arsenic. Environ Res 92:85\u201391","journal-title":"Environ Res"},{"key":"611_CR18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1383-5742(97)00008-2","volume":"386","author":"MJ Mass","year":"1997","unstructured":"Mass MJ, Wang L (1997) Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mutat Res 386:263\u2013277","journal-title":"Mutat Res"},{"key":"611_CR100","doi-asserted-by":"crossref","unstructured":"Miller JW, Nadeau MR, Smith J, Smith D, Selhub J (1994) Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine\u2019s co-ordinate regulation of homocysteine metabolism. Biochem J 298:415\u2013419.","DOI":"10.1042\/bj2980415"},{"key":"611_CR19","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tox.2006.06.005","volume":"225","author":"K Nohara","year":"2006","unstructured":"Nohara K, Ao K, Miyamoto Y, Ito T, Suzuki T, Toyoshiba H, Tohyama C (2006) Comparison of the 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: most potent induction in humans. Toxicology 225:204\u2013213","journal-title":"Toxicology"},{"key":"611_CR20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/carcin\/23.5.777","volume":"23","author":"RS Okoji","year":"2002","unstructured":"Okoji RS, Yu RC, Maronpot RR, Froines JR (2002) Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL\/6J mice. Carcinogenesis 23:777\u2013785","journal-title":"Carcinogenesis"},{"key":"611_CR21","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1289\/ehp.11872","volume":"117","author":"JR Pilsner","year":"2009","unstructured":"Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV (2009) Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions. Environ Health Perspect 117:254\u2013260","journal-title":"Environ Health Perspect"},{"key":"611_CR22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mrfmmm.2003.12.014","volume":"548","author":"IP Pogribny","year":"2004","unstructured":"Pogribny IP, James SJ, Jernigan S, Pogribna M (2004) Genomic hypomethylation is specific for preneoplastic liver in folate\/methyl deficient rats and does not occur in non-target tissues. Mutation Res 548:53\u201359","journal-title":"Mutation Res"},{"key":"611_CR23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mrfmmm.2009.05.003","volume":"669","author":"IP Pogribny","year":"2009","unstructured":"Pogribny IP, Shpyleva SI, Muskhelishvili L, Bagnyukova TV, James SJ, Beland FA (2009) Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet. Mutat Res 669:56\u201362","journal-title":"Mutat Res"},{"key":"611_CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2217\/epi.09.45","volume":"2","author":"JF Reichard","year":"2010","unstructured":"Reichard JF, Puga A (2010) Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics 2:87\u2013104","journal-title":"Epigenomics"},{"key":"611_CR25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2006.11.001","volume":"352","author":"JF Reichard","year":"2007","unstructured":"Reichard JF, Schnekenburger M, Puga A (2007) Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun 352:188\u2013192","journal-title":"Biochem Biophys Res Commun"},{"key":"611_CR26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mrfmmm.2003.07.009","volume":"533","author":"TG Rossman","year":"2003","unstructured":"Rossman TG (2003) Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533:37\u201365","journal-title":"Mutat Res"},{"key":"611_CR27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/tx700198a","volume":"21","author":"K Salnikow","year":"2008","unstructured":"Salnikow K, Zhitkovich A (2008) Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21:28\u201344","journal-title":"Chem Res Toxicol"},{"key":"611_CR28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfm177","volume":"100","author":"M Szyf","year":"2007","unstructured":"Szyf M (2007) The dynamic epigenome and its implications in toxicology. Toxicol Sci 100:7\u201323","journal-title":"Toxicol Sci"},{"key":"611_CR29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1289\/ehp.99107727","volume":"107","author":"M Tondel","year":"1999","unstructured":"Tondel M, Rahman M, Magnuson A, Chowdhury IA, Faruquee MH, Ahmad SA (1999) The relationship of arsenic levels in drinking water and the prevalence rate of skin lesions in Bangladesh. Environ Health Perspect 107:727\u2013729","journal-title":"Environ Health Perspect"},{"key":"611_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10590500701201695","volume":"25","author":"CH Tseng","year":"2007","unstructured":"Tseng CH (2007) Arsenic methylation, urinary arsenic metabolites and human diseases: current perspective. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 25:1\u201322","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"611_CR31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-9673(01)93580-0","volume":"290","author":"J Wagner","year":"1984","unstructured":"Wagner J, Danzin C, Huot-Olivier S, Claverie N, Palfreyman MG (1984) High-performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with L-dopa. J Chromatogr 290:247\u2013262","journal-title":"J Chromatogr"},{"key":"611_CR32","doi-asserted-by":"crossref","first-page":"1706S","DOI":"10.1093\/jn\/136.6.1706S","volume":"136","author":"RA Waterland","year":"2006","unstructured":"Waterland RA (2006) Assessing the effects of high methionine intake on DNA methylation. J Nutr 136:1706S\u20131710S","journal-title":"J Nutr"},{"key":"611_CR33","first-page":"138","volume":"1775","author":"AS Wilson","year":"2007","unstructured":"Wilson AS, Power BE, Molloy PL (2007) DNA hypomethylation and human diseases. BBA 1775:138\u2013162","journal-title":"BBA"},{"key":"611_CR34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.taap.2003.10.022","volume":"198","author":"T Yoshida","year":"2004","unstructured":"Yoshida T, Yamauchi H, Fan Sun G (2004) Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol 198:243\u2013252","journal-title":"Toxicol Appl Pharmacol"},{"key":"611_CR35","doi-asserted-by":"crossref","first-page":"10907","DOI":"10.1073\/pnas.94.20.10907","volume":"94","author":"CQ Zhao","year":"1997","unstructured":"Zhao CQ, Young MR, Diwan BA, Coogan TP, Waalkes MP (1997) Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci USA 94:10907\u201310912","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-010-0611-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-010-0611-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-010-0611-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T17:54:50Z","timestamp":1559757290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-010-0611-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,27]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["611"],"URL":"https:\/\/doi.org\/10.1007\/s00204-010-0611-z","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,27]]}}}