{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:58:56Z","timestamp":1791190736457,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,8,11]],"date-time":"2012-08-11T00:00:00Z","timestamp":1344643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00204-012-0912-5","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T05:15:29Z","timestamp":1344575729000},"page":"99-109","source":"Crossref","is-referenced-by-count":99,"title":["Size of TiO2 nanoparticles influences their phototoxicity: an in vitro investigation"],"prefix":"10.1007","volume":"87","author":[{"given":"Sijing","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saji","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Damoiseaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Woei","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Say Chye Joachim","family":"Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,11]]},"reference":[{"issue":"2","key":"912_CR1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/jcat.2002.3783","volume":"212","author":"CB Almquist","year":"2002","unstructured":"Almquist CB, Biswas P (2002) Role of synthesis method and particle size of nanostructured TiO2 on its photoactivity. J Catal 212(2):145\u2013156","journal-title":"J Catal"},{"key":"912_CR2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1743-8977-6-19","volume":"6","author":"JA Araujo","year":"2009","unstructured":"Araujo JA, Nel AE (2009) Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress. Part Fibre Toxicol 6:19. doi: 10.1186\/1743-8977-6-24","journal-title":"Part Fibre Toxicol"},{"key":"912_CR3","doi-asserted-by":"crossref","unstructured":"Bar-Ilan O, Louis KM, Yang SP, Pedersen JA, Hamers RJ, Peterson RE, Heideman W (2011) Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish. Nanotoxicology, 1\u201310.doi: 10.3109\/17435390.2011.604438","DOI":"10.3109\/17435390.2011.604438"},{"issue":"4","key":"912_CR4","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","volume":"287","author":"PS Brookes","year":"2004","unstructured":"Brookes PS, Yoon YS, Robotham JL, Anders MW, Sheu SS (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287(4):C817\u2013C833. doi: 10.1152\/ajpcell.00139.2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"8","key":"912_CR5","first-page":"2346","volume":"52","author":"R Cai","year":"1992","unstructured":"Cai R, Kubota Y, Shuin T, Sakai H, Hashimoto K, Fujishima A (1992) Induction of cytotoxicity by photoexcited TiO2 particles. Cancer Res 52(8):2346\u20132348","journal-title":"Cancer Res"},{"issue":"6","key":"912_CR6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48(6):749\u2013762. doi: 10.1016\/j.freeradbiomed.2009.12.022","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"912_CR7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","volume":"82","author":"W Dr\u00f6ge","year":"2002","unstructured":"Dr\u00f6ge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82(1):47\u201395","journal-title":"Physiol Rev"},{"issue":"11","key":"912_CR8","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1073\/pnas.100422497","volume":"97","author":"S Dukan","year":"2000","unstructured":"Dukan S, Farewell A, Ballesteros M, Taddei F, Radman M, Nystrom T (2000) Protein oxidation in response to increased transcriptional or translational errors. Proc Natl Acad Sci USA 97(11):5746\u20135749. doi: 10.1073\/pnas.100422497","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6809","key":"912_CR9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"T Finkel","year":"2000","unstructured":"Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239\u2013247","journal-title":"Nature"},{"issue":"1","key":"912_CR10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1021\/nn901503q","volume":"4","author":"S George","year":"2009","unstructured":"George S, Pokhrel S, Xia T, Gilbert B, Ji Z, Schowalter M, Rosenauer A, Damoiseaux R, Bradley KA, M\u00e4dler L, Nel AE (2009) Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping. ACS Nano 4(1):15\u201329. doi: 10.1021\/nn901503q","journal-title":"ACS Nano"},{"issue":"29","key":"912_CR11","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1021\/ja202836s","volume":"133","author":"S George","year":"2011","unstructured":"George S, Pokhrel S, Ji Z, Henderson BL, Xia T, Li L, Zink JI, Nel AE, Madler L (2011a) Role of Fe doping in tuning the band gap of TiO2 for the photo-oxidation-induced cytotoxicity paradigm. J Am Chem Soc 133(29):11270\u201311278. doi: 10.1021\/ja202836s","journal-title":"J Am Chem Soc"},{"issue":"3","key":"912_CR12","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1021\/nn102734s","volume":"5","author":"S George","year":"2011","unstructured":"George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE (2011b) Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano 5(3):1805\u20131817. doi: 10.1021\/nn102734s","journal-title":"ACS Nano"},{"issue":"1","key":"912_CR13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/17435390802596456","volume":"3","author":"RC Gopalan","year":"2009","unstructured":"Gopalan RC, Osman IF, Amani A, De Matas M, Anderson D (2009) The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3(1):33\u201339","journal-title":"Nanotoxicology"},{"key":"912_CR14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.nu.16.070196.000341","volume":"16","author":"B Halliwell","year":"1996","unstructured":"Halliwell B (1996) Antioxidants in human health and disease. Annu Rev Nutr 16:33\u201350. doi: 10.1146\/annurev.nutr.16.1.33","journal-title":"Annu Rev Nutr"},{"issue":"6","key":"912_CR15","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.fct.2010.04.023","volume":"48","author":"BC Heng","year":"2010","unstructured":"Heng BC, Zhao X, Xiong S, Ng KW, Boey FY-C, Loo JS-C (2010a) Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food Chem Toxicol 48(6):1762\u20131766","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"912_CR16","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00204-010-0608-7","volume":"85","author":"BC Heng","year":"2010","unstructured":"Heng BC, Zhao X, Xiong S, Ng KW, Boey FYC, Loo JSC (2010b) Cytotoxicity of zinc oxide (ZnO) nanoparticles is influenced by cell density and culture format. Arch Toxicol 85(6):695\u2013704. doi: 10.1007\/s00204-010-0608-7","journal-title":"Arch Toxicol"},{"issue":"1","key":"912_CR17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/cr00033a004","volume":"95","author":"MR Hoffmann","year":"1995","unstructured":"Hoffmann MR, Martin ST, Choi W, Bahnemann DW (1995) Environmental applications of semiconductor photocatalysis. Chem Rev 95(1):69\u201396. doi: 10.1021\/cr00033a004","journal-title":"Chem Rev"},{"issue":"3","key":"912_CR18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1021\/tx800289z","volume":"22","author":"M Horie","year":"2009","unstructured":"Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nakano H, Nanashima N, Niki E, Yoshida Y (2009) Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells. Chem Res Toxicol 22(3):543\u2013553. doi: 10.1021\/tx800289z","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"912_CR19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1017948330363","volume":"3","author":"HD Jang","year":"2001","unstructured":"Jang HD, Kim S-K, Kim S-J (2001) Effect of particle size and phase composition of titanium dioxide nanoparticles on the photocatalytic properties. J Nanopart Res 3(2):141\u2013147. doi: 10.1023\/a:1017948330363","journal-title":"J Nanopart Res"},{"issue":"19","key":"912_CR20","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1021\/es100417s","volume":"44","author":"Z Ji","year":"2010","unstructured":"Ji Z, Jin X, George S, Xia T, Meng H, Wang X, Suarez E, Zhang H, Hoek EMV, Godwin H, Nel AE, Zink JI (2010) Dispersion and stability optimization of TiO2 nanoparticles in cell culture media. Environ Sci Technol 44(19):7309\u20137314. doi: 10.1021\/es100417s","journal-title":"Environ Sci Technol"},{"issue":"2\u20133","key":"912_CR21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jphotochem.2010.06.031","volume":"214","author":"N Lagopati","year":"2010","unstructured":"Lagopati N, Kitsiou PV, Kontos AI, Venieratos P, Kotsopoulou E, Kontos AG, Dionysiou DD, Pispas S, Tsilibary EC, Falaras P (2010) Photo-induced treatment of breast epithelial cancer cells using nanostructured titanium dioxide solution. J Photochem Photobiol A 214(2\u20133):215\u2013223","journal-title":"J Photochem Photobiol A"},{"issue":"7113","key":"912_CR22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443(7113):787\u2013795","journal-title":"Nature"},{"issue":"2","key":"912_CR23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0041-008X(90)90026-Q","volume":"102","author":"RC Lindenschmidt","year":"1990","unstructured":"Lindenschmidt RC, Driscoll KE, Perkins MA, Higgins JM, Maurer JK, Belfiore KA (1990) The comparison of a fibrogenic and two nonfibrogenic dusts by bronchoalveolar lavage. Toxicol Appl Pharmacol 102(2):268\u2013281","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"912_CR24","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1128\/AEM.65.9.4094-4098.1999","volume":"65","author":"PC Maness","year":"1999","unstructured":"Maness PC, Smolinski S, Blake DM, Huang Z, Wolfrum EJ, Jacoby WA (1999) Bactericidal activity of photocatalytic TiO2 reaction: toward an understanding of its killing mechanism. Appl Environ Microbiol 65(9):4094\u20134098","journal-title":"Appl Environ Microbiol"},{"issue":"7117","key":"912_CR25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/444267a","volume":"444","author":"AD Maynard","year":"2006","unstructured":"Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdorster G, Philbert MA, Ryan J, Seaton A, Stone V, Tinkle SS, Tran L, Walker NJ, Warheit DB (2006) Safe handling of nanotechnology. Nature 444(7117):267\u2013269","journal-title":"Nature"},{"issue":"10","key":"912_CR26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nnano.2011.169","volume":"6","author":"MJ McCall","year":"2011","unstructured":"McCall MJ (2011) Environmental, health and safety issues nanoparticles in the real world. Nat Nanotechnol 6(10):613\u2013614","journal-title":"Nat Nanotechnol"},{"issue":"7","key":"912_CR27","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/nn9005973","volume":"3","author":"H Meng","year":"2009","unstructured":"Meng H, Xia T, George S, Nel AE (2009) A predictive toxicological paradigm for the safety assessment of nanomaterials. ACS Nano 3(7):1620\u20131627. doi: 10.1021\/nn9005973","journal-title":"ACS Nano"},{"issue":"2","key":"912_CR28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nnano.2010.191","volume":"6","author":"J Morris","year":"2011","unstructured":"Morris J, Willis J, De Martinis D, Hansen B, Laursen H, Sintes JR, Kearns P, Gonzalez M (2011) Science policy considerations for responsible nanotechnology decisions. Nat Nano 6(2):73\u201377","journal-title":"Nat Nano"},{"issue":"1\u20133","key":"912_CR29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1383-5718(97)00126-5","volume":"394","author":"Y Nakagawa","year":"1997","unstructured":"Nakagawa Y, Wakuri S, Sakamoto K, Tanaka N (1997) The photogenotoxicity of titanium dioxide particles. Mutation Res Genet Toxicol Environ Mutagen 394(1\u20133):125\u2013132","journal-title":"Mutation Res Genet Toxicol Environ Mutagen"},{"issue":"5761","key":"912_CR30","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","volume":"311","author":"A Nel","year":"2006","unstructured":"Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nanolevel. Science 311(5761):622\u2013627. doi: 10.1126\/science.1114397","journal-title":"Science"},{"issue":"32","key":"912_CR31","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1016\/j.biomaterials.2011.07.036","volume":"32","author":"KW Ng","year":"2011","unstructured":"Ng KW, Khoo SPK, Heng BC, Setyawati MI, Tan EC, Zhao X, Xiong S, Fang W, Leong DT, Loo JSC (2011) The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticles. Biomaterials 32(32):8218\u20138225","journal-title":"Biomaterials"},{"issue":"7","key":"912_CR32","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","volume":"113","author":"G Oberd\u00f6rster","year":"2005","unstructured":"Oberd\u00f6rster G, Oberd\u00f6rster E, Oberd\u00f6rster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823\u2013839. doi: 10.1289\/ehp.7339","journal-title":"Environ Health Perspect"},{"issue":"3","key":"912_CR33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.5271\/sjweh.3104","volume":"5","author":"EM Ophus","year":"1979","unstructured":"Ophus EM, Rode L, Gylseth B, Nicholson DG, Saeed K (1979) Analysis of titanium pigments in human lung tissue. Scand J Work Environ Health 5(3):290\u2013296","journal-title":"Scand J Work Environ Health"},{"issue":"6\u20137","key":"912_CR34","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.molimm.2004.04.013","volume":"41","author":"AL Perraud","year":"2004","unstructured":"Perraud AL, Knowles HM, Schmitz C (2004) Novel aspects of signaling and ion-homeostasis regulation in immunocytes: the TRPM ion channels and their potential role in modulating the immune response. Mol Immunol 41(6\u20137):657\u2013673","journal-title":"Mol Immunol"},{"issue":"1\u20132","key":"912_CR35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mrfmmm.2007.12.010","volume":"640","author":"JF Reeves","year":"2008","unstructured":"Reeves JF, Davies SJ, Dodd NJF, Jha AN (2008) Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutation Res Fundam Mol Mech Mutagen 640(1\u20132):113\u2013122","journal-title":"Mutation Res Fundam Mol Mech Mutagen"},{"issue":"2","key":"912_CR36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.colsurfb.2009.02.019","volume":"71","author":"CK Simi","year":"2009","unstructured":"Simi CK, Abraham TE (2009) Nanocomposite based on modified TiO2-BSA for functional applications. Colloid Surf B Biointerfaces 71(2):319\u2013324. doi: 10.1016\/j.colsurfb.2009.02.019","journal-title":"Colloid Surf B Biointerfaces"},{"issue":"4","key":"912_CR37","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2478\/v10019-011-0037-0","volume":"45","author":"M Skocaj","year":"2011","unstructured":"Skocaj M, Filipic M, Petkovic J, Novak S (2011) Titanium dioxide in our everyday life; is it safe? Radiol Oncol 45(4):227\u2013247. doi: 10.2478\/v10019-011-0037-0","journal-title":"Radiol Oncol"},{"issue":"5074","key":"912_CR38","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1355616","volume":"257","author":"ER Stadtman","year":"1992","unstructured":"Stadtman ER (1992) Protein oxidation and aging. Science 257(5074):1220\u20131224. doi: 10.1126\/science.1355616","journal-title":"Science"},{"issue":"1\u20132","key":"912_CR39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cattod.2010.02.016","volume":"151","author":"E Stefanou","year":"2010","unstructured":"Stefanou E, Evangelou A, Falaras P (2010) Effects of UV-irradiated titania nanoparticles on cell proliferation, cancer metastasis and promotion. Catal Today 151(1\u20132):58\u201363","journal-title":"Catal Today"},{"issue":"6","key":"912_CR40","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1083\/jcb.141.6.1423","volume":"141","author":"S Tan","year":"1998","unstructured":"Tan S, Sagara Y, Liu Y, Maher P, Schubert D (1998) The regulation of reactive oxygen species production during programmed cell death. J Cell Biol 141(6):1423\u20131432. doi: 10.1083\/jcb.141.6.1423","journal-title":"J Cell Biol"},{"issue":"1\u20132","key":"912_CR41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1011268421046","volume":"22","author":"Y Tanaka","year":"2001","unstructured":"Tanaka Y, Suganuma M (2001) Effects of heat treatment on photocatalytic property of sol-gel derived polycrystalline TiO2. J Sol-Gel Sci Technol 22(1\u20132):83\u201389. doi: 10.1023\/a:1011268421046","journal-title":"J Sol-Gel Sci Technol"},{"key":"912_CR42","unstructured":"Vidosava BD (2004) Free radicals in cell biology. In: International review of cytology, vol 237. Academic Press, Serbia and Montenegro, pp 57\u201389"},{"issue":"8","key":"912_CR43","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/nl061025k","volume":"6","author":"T Xia","year":"2006","unstructured":"Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794\u20131807","journal-title":"Nano Lett"},{"issue":"10","key":"912_CR44","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1021\/nn800511k","volume":"2","author":"T Xia","year":"2008","unstructured":"Xia T, Kovochich M, Liong M, M\u00e4dler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2(10):2121\u20132134. doi: 10.1021\/nn800511k","journal-title":"ACS Nano"},{"issue":"5","key":"912_CR45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/biot.201000351","volume":"6","author":"S Xiong","year":"2011","unstructured":"Xiong S, Zhao X, Heng BC, Ng KW, Loo JSC (2011) Cellular uptake of Poly-(d, l-lactide-co-glycolide) (PLGA) nanoparticles synthesized through solvent emulsion evaporation and nanoprecipitation method. Biotechnol J 6(5):501\u2013508","journal-title":"Biotechnol J"},{"issue":"1","key":"912_CR46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/etc.718","volume":"31","author":"JL Zhang","year":"2010","unstructured":"Zhang JL, Wages M, Cox SB, Maul JD, Li YJ, Barnes M, Hope-Weeks L, Cobb GP (2010) Effect of titanium dioxide nanomaterials and ultraviolet light coexposure on African clawed frogs (Xenopus laevis). Environ Toxicol Chem 31(1):176\u2013183. doi: 10.1002\/etc.718","journal-title":"Environ Toxicol Chem"},{"issue":"2","key":"912_CR47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/17435390.2010.503943","volume":"5","author":"XX Zhao","year":"2010","unstructured":"Zhao XX, Heng BC, Xiong SJ, Guo J, Tan TTY, Boey FYC, Ng KW, Loo JSC (2010) In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas. Nanotoxicology 5(2):182\u2013194. doi: 10.3109\/17435390.2010.503943","journal-title":"Nanotoxicology"},{"key":"912_CR48","doi-asserted-by":"crossref","unstructured":"Zhao X, Ng S, Heng BC, Guo J, Ma L, Tan TTY, Ng KW, Loo SCJ (2012) Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent. Arch Toxicol, 1\u201316. doi: 10.1007\/s00204-012-0827-1","DOI":"10.1007\/s00204-012-0827-1"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0912-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-012-0912-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0912-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T12:31:32Z","timestamp":1594557092000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-012-0912-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,11]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["912"],"URL":"https:\/\/doi.org\/10.1007\/s00204-012-0912-5","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,11]]}}}