{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:10:19Z","timestamp":1790917819166,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,11,11]],"date-time":"2012-11-11T00:00:00Z","timestamp":1352592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s00204-012-0976-2","type":"journal-article","created":{"date-parts":[[2012,11,10]],"date-time":"2012-11-10T08:03:55Z","timestamp":1352534635000},"page":"763-766","source":"Crossref","is-referenced-by-count":26,"title":["Induction of skin sensitization is augmented in Nrf2-deficient mice"],"prefix":"10.1007","volume":"87","author":[{"given":"Jochem W.","family":"van der Veen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Gremmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanda P.","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"van Loveren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Ezendam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,11]]},"reference":[{"key":"976_CR1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/toxsci\/kfn243","volume":"107","author":"N Ade","year":"2009","unstructured":"Ade N, Leon F, Pallardy M, Peiffer JL, Kerdine-Romer S, Tissier MH, Bonnet PA, Fabre I, Ourlin JC (2009) HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1\/Nrf2 pathway. Toxicol Sci 107:451\u2013460","journal-title":"Toxicol Sci"},{"key":"976_CR2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/jat.1684","volume":"32","author":"D Basketter","year":"2012","unstructured":"Basketter D, Kolle SN, Schrage A, Honarvar N, Gamer AO, van Ravenzwaay B, Landsiedel R (2012) Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements. J Appl Toxicol 32:590\u2013596","journal-title":"J Appl Toxicol"},{"key":"976_CR3","doi-asserted-by":"crossref","first-page":"13943","DOI":"10.1073\/pnas.93.24.13943","volume":"93","author":"K Chan","year":"1996","unstructured":"Chan K, Lu R, Chang JC, Kan YW (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A 93:13943\u201313948","journal-title":"Proc Natl Acad Sci U S A"},{"key":"976_CR4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.taap.2010.03.009","volume":"245","author":"R Emter","year":"2010","unstructured":"Emter R, Ellis G, Natsch A (2010) Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol Appl Pharmacol 245:281\u2013290","journal-title":"Toxicol Appl Pharmacol"},{"key":"976_CR5","doi-asserted-by":"crossref","first-page":"e41340","DOI":"10.1371\/journal.pone.0041340","volume":"7","author":"PR Esser","year":"2012","unstructured":"Esser PR, Wolfle U, Durr C, von Loewenich FD, Schempp CM, Freudenberg MA, Jakob T, Martin SF (2012) Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation. PLoS ONE 7:e41340","journal-title":"PLoS ONE"},{"key":"976_CR6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/1471-2164-12-399","volume":"12","author":"H Johansson","year":"2011","unstructured":"Johansson H, Lindstedt M, Albrekt AS, Borrebaeck CA (2011) A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics 12:399","journal-title":"BMC Genomics"},{"key":"976_CR7","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jaci.2008.01.016","volume":"121","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Barajas B, Wang M, Nel AE (2008) Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. J Allergy Clin Immunol 121:1255\u20131261","journal-title":"J Allergy Clin Immunol"},{"key":"976_CR8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrfmmm.2009.09.007","volume":"690","author":"J Kim","year":"2010","unstructured":"Kim J, Cha YN, Surh YJ (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res 690:12\u201323","journal-title":"Mutat Res"},{"key":"976_CR9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-0625.2007.00581.x","volume":"16","author":"J Listopad","year":"2007","unstructured":"Listopad J, Asadullah K, Sievers C, Ritter T, Meisel C, Sabat R, Docke WD (2007) Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells. Exp Dermatol 16:661\u2013670","journal-title":"Exp Dermatol"},{"key":"976_CR10","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1398-9995.2011.02652.x","volume":"66","author":"SF Martin","year":"2011","unstructured":"Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M (2011) Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy 66:1152\u20131163","journal-title":"Allergy"},{"key":"976_CR11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/toxsci\/kfp228","volume":"113","author":"A Natsch","year":"2010","unstructured":"Natsch A (2010) The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers\u2013functional relevance and a hypothesis on innate reactions to skin sensitizers. Toxicol Sci 113:284\u2013292","journal-title":"Toxicol Sci"},{"key":"976_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.taap.2009.06.003","volume":"239","author":"F Python","year":"2009","unstructured":"Python F, Goebel C, Aeby P (2009) Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol 239:273\u2013283","journal-title":"Toxicol Appl Pharmacol"},{"key":"976_CR13","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.4049\/jimmunol.181.10.6730","volume":"181","author":"SA Rushworth","year":"2008","unstructured":"Rushworth SA, MacEwan DJ, O\u2019Connell MA (2008) Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. J Immunol 181:6730\u20136737","journal-title":"J Immunol"},{"key":"976_CR14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/toxsci\/66.2.298","volume":"66","author":"W Slob","year":"2002","unstructured":"Slob W (2002) Dose-response modelling of continuous endpoints. Toxicol Sci 66:298\u2013312","journal-title":"Toxicol Sci"},{"key":"976_CR15","doi-asserted-by":"crossref","unstructured":"van der Veen JW, Pronk TE, van Loveren H, Ezendam J (2012) Applicability of a keratinocyte gene signature to predict skin sensitizing potential. Toxicol In Vitro, Ahead of print","DOI":"10.1016\/j.tiv.2012.08.023"},{"key":"976_CR16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/toxsci\/kfq182","volume":"117","author":"RJ Vandebriel","year":"2010","unstructured":"Vandebriel RJ, Pennings JL, Baken KA, Pronk TE, Boorsma A, Gottschalk R, Van Loveren H (2010) Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci 117:81\u201389","journal-title":"Toxicol Sci"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0976-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-012-0976-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-012-0976-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T13:18:17Z","timestamp":1562332697000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-012-0976-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,11]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["976"],"URL":"https:\/\/doi.org\/10.1007\/s00204-012-0976-2","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,11]]}}}