{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:07:29Z","timestamp":1793142449457,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s00204-013-1098-1","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T07:41:44Z","timestamp":1375774904000},"page":"127-136","source":"Crossref","is-referenced-by-count":40,"title":["Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity"],"prefix":"10.1007","volume":"88","author":[{"given":"Michael","family":"Stern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gierse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saime","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Bicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"1098_CR1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.14573\/altex.2012.2.202","volume":"29","author":"AK Bal-Price","year":"2012","unstructured":"Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AEM, Kreysa J (2012) Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. Altex 29:202\u2013215","journal-title":"Altex"},{"key":"1098_CR2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.nbd.2007.02.008","volume":"26","author":"S Bassanini","year":"2007","unstructured":"Bassanini S, Hallene K, Battaglia G, Finardi A, Santaguida S, Cipolla M, Janigro D (2007) Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol. Neurobiol Dis 26:481\u2013495","journal-title":"Neurobiol Dis"},{"key":"1098_CR3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/dev.420070210","volume":"7","author":"HK Berry","year":"1974","unstructured":"Berry HK, Butcher RE, Elliott LA, Brunner RL (1974) The effect of monosodium glutamate on the early biochemical and behavioral development of the rat. Develop Psychobiol 7:165\u2013173","journal-title":"Develop Psychobiol"},{"key":"1098_CR4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ntt.2009.06.005","volume":"32","author":"JM Breier","year":"2010","unstructured":"Breier JM, Gassmann K, Kayser R, Stegeman H, de Groot D, Fritsche E, Shafer TJ (2010) Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science. Neurotoxicol Teratol 32:4\u201315","journal-title":"Neurotoxicol Teratol"},{"key":"1098_CR5","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1002\/stem.179","volume":"27","author":"L Buzanska","year":"2009","unstructured":"Buzanska L, Sypecka J, Nerini-Molteni S, Compagnoni A, Hogberg HT, del Torchio R, Domanska-Janik K, Zimmer J, Coecke S (2009) A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system. Stem Cells 27:2591\u20132601","journal-title":"Stem Cells"},{"key":"1098_CR6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1177\/1073858403253552","volume":"9","author":"MF Casanova","year":"2003","unstructured":"Casanova MF, Buxhoeveden D, Gomez J (2003) Disruption in the inhibitory architecture of the cell minicolumn: implications for autism. Neuroscientist 9:496\u2013507","journal-title":"Neuroscientist"},{"key":"1098_CR7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1152\/physrev.1997.77.1.199","volume":"77","author":"F Cattabeni","year":"1997","unstructured":"Cattabeni F, de Luca M (1997) Developmental models of brain dysfunctions induced by targeted cell ablations with methylazoxymethanol. Physiol Rev 77:199\u2013213","journal-title":"Physiol Rev"},{"key":"1098_CR8","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1289\/ehp.9427","volume":"115","author":"S Coecke","year":"2007","unstructured":"Coecke S, Goldberg AM, Allen S, Buzanska L, Calamandrei G, Crofton K, Hareng L, Hartung T, Knaut H, Honegger P, Jacobs M, Lein P, Li A, Mundy W, Owen D, Schneider S, Silbergeld E, Reum T, Trnovec T, Monnet-Tschudi F, Bal-Price A (2007) Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ Health Perspect 115:924\u2013931","journal-title":"Environ Health Perspect"},{"key":"1098_CR9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.14573\/altex.2011.1.009","volume":"28","author":"KM Crofton","year":"2011","unstructured":"Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Seiler AEM, Knaut H, Buzanska L, Goldberg A (2011) Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. ALTEX 28:9\u201314","journal-title":"ALTEX"},{"key":"1098_CR10","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.tiv.2009.07.017","volume":"23","author":"A Forsby","year":"2009","unstructured":"Forsby A, Bal-Price AK, Camins A, Coecke S, Fabre N, Gustafsson H, Honegger P, Kinsner-Ovaskainen A, Pallas M, Rimbau V, Rodr\u00edguez-Farr\u00e9 E, Su\u00f1ol C, Vericat JA, Zurich MG (2009) Neuronal in vitro models for the estimation of acute systemic toxicity. Toxicol In Vitro 23:1564\u20131569","journal-title":"Toxicol In Vitro"},{"issue":"Suppl 3","key":"1098_CR11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1289\/ehp.00108s3443","volume":"108","author":"LR Goldman","year":"2000","unstructured":"Goldman LR, Koduru S (2000) Chemicals in the environment and developmental toxicity to children: a public health and policy perspective. Environ Health Perspect 108(Suppl 3):443\u2013448","journal-title":"Environ Health Perspect"},{"key":"1098_CR12","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","volume":"368","author":"P Grandjean","year":"2006","unstructured":"Grandjean P, Landrigan PJ (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368:2167\u20132178","journal-title":"Lancet"},{"key":"1098_CR13","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev.neuro.22.1.511","volume":"22","author":"ME Hatten","year":"1999","unstructured":"Hatten ME (1999) Central nervous system neuronal migration. Annu Rev Neurosci 22:511\u2013539","journal-title":"Annu Rev Neurosci"},{"key":"1098_CR14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.etap.2013.03.018","volume":"36","author":"A Herrera","year":"2013","unstructured":"Herrera A, Pineda J, Antonio MT (2013) Toxic effects of perinatal arsenic exposure on the brain of developing rats and the beneficial role of natural antioxidants. Environ Toxicol Pharmacol 36:73\u201379","journal-title":"Environ Toxicol Pharmacol"},{"key":"1098_CR15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tox.2008.05.014","volume":"249","author":"EJ Hill","year":"2008","unstructured":"Hill EJ, Woehrling EK, Prince M, Coleman MD (2008) Differentiating human NT2\/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology 249:243\u2013250","journal-title":"Toxicology"},{"key":"1098_CR16","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2741\/4064","volume":"17","author":"S Kadereit","year":"2012","unstructured":"Kadereit S, Zimmer B, van Thriel C, Hengstler JG, Leist M (2012) Compound selection for in vitro modeling of developmental neurotoxicity. Front Biosci 17:2442\u20132460","journal-title":"Front Biosci"},{"key":"1098_CR17","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1128\/AAC.40.5.1104","volume":"40","author":"M Karlsson","year":"1996","unstructured":"Karlsson M, Hammers S, Nilsson-Ehle I, Malmborg AS, Wretlind B (1996) Concentrations of doxycycline and penicillin G in sera and cerebrospinal fluid of patients treated for neuroborreliosis. Antimicrob Agents Chemother 40:1104\u20131107","journal-title":"Antimicrob Agents Chemother"},{"key":"1098_CR18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.dnarep.2008.12.002","volume":"8","author":"GE Kisby","year":"2009","unstructured":"Kisby GE, Olivas A, Park T, Churchwell M, Doerge D, Samson LD, Gerson SL, Turker MS (2009) DNA repair modulates the vulnerability of the developing brain to alkylating agent. DNA Repair (Amst) 8:400\u2013412","journal-title":"DNA Repair (Amst)"},{"key":"1098_CR19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-012-0967-3","volume":"87","author":"AK Krug","year":"2013","unstructured":"Krug AK, Kolde R, Gaspar JA, Rempel E, Balmer NV, Meganathan K, Vojnits K, Baqui\u00e9 M, Waldmann T, Ensenat-Waser R, Jagtap S, Evans RM, Julien S, Peterson H, Zagoura D, Kadereit S, Gerhard D, Sotiriadou I, Heke M, Natarajan K, Henry M, Winkler J, Marchan R, Stoppini L, Bosgra S, Westerhout J, Verwei M, Vilo J, Kortenkamp A, Hescheler J, Hothorn L, Bremer S, van Thriel C, Krause K, Hengstler JG, Rahnenf\u00fchrer J, Leist M, Sachinidis A (2013) Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol 87:123\u2013143","journal-title":"Arch Toxicol"},{"key":"1098_CR20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.etap.2004.12.035","volume":"19","author":"P Lein","year":"2005","unstructured":"Lein P, Silbergeld E, Locke P, Goldberg AM (2005) In vitro and other alternative approaches to developmental neurotoxicity testing (DNT). Environ Toxicol Pharmacol 19:735\u2013744","journal-title":"Environ Toxicol Pharmacol"},{"key":"1098_CR21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1289\/ehp.9841","volume":"115","author":"P Lein","year":"2007","unstructured":"Lein P, Locke P, Goldberg A (2007) Meeting report: alternatives for developmental neurotoxicity testing. Environ Health Perspect 115:764\u2013768","journal-title":"Environ Health Perspect"},{"key":"1098_CR22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11910-010-0176-5","volume":"11","author":"JS Liu","year":"2011","unstructured":"Liu JS (2011) Molecular genetics of neuronal migration disorders. Curr Neurol Neurosci Rep 11:171\u2013178","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1098_CR23","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1289\/ehp.0800207","volume":"117","author":"M Moors","year":"2009","unstructured":"Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E (2009) Human neurospheres as three dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117:1131\u20131138","journal-title":"Environ Health Perspect"},{"key":"1098_CR24","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0002-9440(10)62546-1","volume":"160","author":"PT Nelson","year":"2002","unstructured":"Nelson PT, Kondziolka D, Wechsler L, Goldstein S, Gebel J, DeCesare S, Elder EM, Zhang PJ, Jacobs A, McGrogan M, Lee VM, Trojanowski JQ (2002) Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27\u00a0months after implantation. Am J Pathol 160:1201\u20131206","journal-title":"Am J Pathol"},{"key":"1098_CR25","unstructured":"OECD (2007) Test Guideline 426. OECD guideline for testing of chemicals. Developmental neurotoxicity study. http:\/\/www.oecd.org\/document\/55\/0,3343,en_2649_34377_2349687_1_1_1_1,00.html . Accessed 5 March 2013"},{"key":"1098_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","volume":"28","author":"A Ornoy","year":"2009","unstructured":"Ornoy A (2009) Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reprod Toxicol 28:1\u201310","journal-title":"Reprod Toxicol"},{"key":"1098_CR27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2174\/156652407781695747","volume":"7","author":"F Paquet-Durand","year":"2007","unstructured":"Paquet-Durand F, Bicker G (2007) Human model neurons in studies of brain cell damage and neural repair. Curr Mol Med 7:541\u2013554","journal-title":"Curr Mol Med"},{"key":"1098_CR28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0165-3806(03)00065-8","volume":"142","author":"F Paquet-Durand","year":"2003","unstructured":"Paquet-Durand F, Tan S, Bicker G (2003) Turning teratocarcinoma cells into neurons: rapid differentiation of NT-2 cells in floating spheres. Brain Res Dev Brain Res 142:161\u2013167","journal-title":"Brain Res Dev Brain Res"},{"key":"1098_CR29","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1523\/JNEUROSCI.12-05-01802.1992","volume":"12","author":"SJ Pleasure","year":"1992","unstructured":"Pleasure SJ, Page CP, Lee VM (1992) Pure, postmitotic, polarized human neurons derived from NTera2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J Neurosci 12:1802\u20131815","journal-title":"J Neurosci"},{"key":"1098_CR30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-009-0783-0","volume":"336","author":"G Podrygajlo","year":"2009","unstructured":"Podrygajlo G, Tegenge MA, Gierse A, Paquet-Durand F, Tan S, Bicker G, Stern M (2009) Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture. Cell Tissue Res 336:439\u2013452","journal-title":"Cell Tissue Res"},{"key":"1098_CR31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neulet.2009.10.092","volume":"468","author":"G Podrygajlo","year":"2010","unstructured":"Podrygajlo G, Song Y, Schlesinger F, Krampfl K, Bicker G (2010) Synaptic currents and transmitter responses in human NT2 neurons differentiated in aggregate culture. Neurosci Lett 468:207\u2013210","journal-title":"Neurosci Lett"},{"key":"1098_CR32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/toxsci\/kfn114","volume":"105","author":"NM Radio","year":"2008","unstructured":"Radio NM, Breier JM, Shafer TJ, Mundy WR (2008) Assessment of chemical effects on neurite outgrowth in PC12 cells using high content screening. Toxicol Sci 105:106\u2013118","journal-title":"Toxicol Sci"},{"key":"1098_CR33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1126\/science.3291116","volume":"241","author":"P Rakic","year":"1988","unstructured":"Rakic P (1988) Specification of cerebral cortical areas. Science 241:170\u2013176","journal-title":"Science"},{"key":"1098_CR34","volume-title":"The principles of humane experimental technique","author":"WMS Russel","year":"1959","unstructured":"Russel WMS, Burch RL (1959) The principles of humane experimental technique. Methuen, London"},{"issue":"Suppl 6","key":"1098_CR35","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1289\/ehp.01109s6813","volume":"109","author":"T Schettler","year":"2001","unstructured":"Schettler T (2001) Toxic threats to neurologic development of children. Environ Health Perspect 109(Suppl 6):813\u2013816","journal-title":"Environ Health Perspect"},{"key":"1098_CR36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1471-4159.2011.07255.x","volume":"119","author":"D Scholz","year":"2011","unstructured":"Scholz D, Poltl D, Genewsky A, Wenig M, Walmann T, Schildknecht S, Leist M (2011) Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line. J Neurochem 119:957\u2013971","journal-title":"J Neurochem"},{"key":"1098_CR37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/B978-0-12-398339-8.00006-9","volume":"63","author":"RL Sison-Young","year":"2012","unstructured":"Sison-Young RL, Kia R, Heslop J, Kelly L, Rowe C, Cross MJ, Kitteringham NR, Hanley N, Park BK, Goldring CE (2012) Human pluripotent stem cells for modeling toxicity. Adv Pharmacol 63:207\u2013256","journal-title":"Adv Pharmacol"},{"key":"1098_CR38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00280-007-0519-3","volume":"61","author":"SL Stapleton","year":"2008","unstructured":"Stapleton SL, Thompson PA, Ou CN, Berg SL, McGuffey L, Gibson B, Blaney SM (2008) Plasma and cerebrospinal fluid pharmacokinetics of valproic acid after oral administration in non-human primates. Cancer Chemother Pharmacol 61:647\u2013652","journal-title":"Cancer Chemother Pharmacol"},{"key":"1098_CR39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1471-4159.2006.03718.x","volume":"97","author":"C Tamm","year":"2006","unstructured":"Tamm C, Duckworth J, Hermanson O, Ceccatelli S (2006) High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J Neurochem 97:69\u201378","journal-title":"J Neurochem"},{"key":"1098_CR40","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1111\/j.1471-4159.2009.06279.x","volume":"110","author":"MA Tegenge","year":"2009","unstructured":"Tegenge MA, Bicker G (2009) Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells. J Neurochem 110:1828\u20131841","journal-title":"J Neurochem"},{"key":"1098_CR41","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/j.1471-4159.2009.06421.x","volume":"111","author":"MA Tegenge","year":"2009","unstructured":"Tegenge MA, Stern M, Bicker G (2009) Nitric oxide and cyclic nucleotide signal transduction modulates synaptic vesicle turnover in human model neurons. J Neurochem 111:1434\u20131446","journal-title":"J Neurochem"},{"key":"1098_CR42","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s00018-010-0554-9","volume":"68","author":"MA Tegenge","year":"2011","unstructured":"Tegenge MA, Rockel TD, Fritsche E, Bicker G (2011) Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci 68:2089\u20132099","journal-title":"Cell Mol Life Sci"},{"key":"1098_CR43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0161-813X(03)00029-9","volume":"24","author":"SY Tsai","year":"2003","unstructured":"Tsai SY, Chou HY, The HW, Chen CM, Chen CJ (2003) The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology 24:747\u2013753","journal-title":"Neurotoxicology"},{"key":"1098_CR44","unstructured":"US EPA\u2014United States Environmental Protection Agency (1998) Health effects test guidelines OPPTS 870.6300 developmental neurotoxicity study. Washington DC, United States Environmental Protection Agency Office of Prevention, Pesticides and Toxic Substances. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPPT-2009-0156-0042 . Accessed 5 March 2013"},{"key":"1098_CR45","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00228-003-0622-2","volume":"59","author":"CD Marel van der","year":"2003","unstructured":"van der Marel CD, Anderson BJ, Pluim MA, de Jong TH, Gonzalez A, Tibboel D (2003) Acetaminophen in cerebrospinal fluid in children. Eur J Clin Pharmacol 59:297\u2013302","journal-title":"Eur J Clin Pharmacol"},{"key":"1098_CR46","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuro.2012.06.006","volume":"33","author":"A Visan","year":"2012","unstructured":"Visan A, Hayess K, Sittner D, Pohl EE, Riebeling C, Slawik B, Gulich K, Oelgeschl\u00e4ger M, Luch A, Seiler AE (2012) Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro. Neurotoxicology 33:1135\u20131146","journal-title":"Neurotoxicology"},{"key":"1098_CR47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12011-009-8455-1","volume":"134","author":"S Xi","year":"2010","unstructured":"Xi S, Jin Y, Lv X, Sun G (2010) Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in offspring rats. Biol Trace Elem Res 134:84\u201397","journal-title":"Biol Trace Elem Res"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-013-1098-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-013-1098-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-013-1098-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T12:21:49Z","timestamp":1563625309000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-013-1098-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["1098"],"URL":"https:\/\/doi.org\/10.1007\/s00204-013-1098-1","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,7]]}}}