{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:27:29Z","timestamp":1759692449565},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T00:00:00Z","timestamp":1399161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s00204-014-1252-4","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T06:09:12Z","timestamp":1399097352000},"page":"87-100","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Targeting oxidative stress in the hypothalamus: the effect of transcription factor STAT3 knockdown on endogenous antioxidants-mediated appetite control"],"prefix":"10.1007","volume":"89","author":[{"given":"Dong-Yih","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Shou","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,4]]},"reference":[{"key":"1252_CR1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/mcne.2000.0947","volume":"17","author":"MA Aberg","year":"2001","unstructured":"Aberg MA, Rytts\u00e9n F, Hellgren G, Lindell K, Rosengren LE, MacLennan AJ et al (2001) Selective introduction of antisense oligonucleotides into single adult CNS progenitor cells using electroporation demonstrates the requirement of STAT3 activation for CNTF-induced gliogenesis. Mol Cell Neurosci 17:426\u2013443","journal-title":"Mol Cell Neurosci"},{"key":"1252_CR2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/syn.20126","volume":"56","author":"M Alexander","year":"2005","unstructured":"Alexander M, Rothman RB, Baumann MH, Endres CJ, Brasic JR, Wong DF (2005) Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio anubis. Synapse 56:94\u201399","journal-title":"Synapse"},{"key":"1252_CR3","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature07181","volume":"454","author":"ZB Andrews","year":"2008","unstructured":"Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM et al (2008) UCP2 mediates ghrelin\u2019s action on NPY\/AgRP neurons by lowering free radicals. Nature 454:846\u2013851","journal-title":"Nature"},{"key":"1252_CR4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1042\/bj3240025","volume":"324","author":"S Baez","year":"1997","unstructured":"Baez S, Segura-Aguilar J, Widersten M, Johansson AS, Mannervik B (1997) Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem J 324:25\u201328","journal-title":"Biochem J"},{"key":"1252_CR5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/db06-0440","volume":"56","author":"A Benani","year":"2007","unstructured":"Benani A, Troy S, Carmona MC, Fioramonti X, Lorsignol A, Leloup C et al (2007) Role of mitochondria reactive oxygen species in brain lipid sensing. Diabetes 56:152\u2013160","journal-title":"Diabetes"},{"key":"1252_CR6","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1096\/fj.06-5896com","volume":"20","author":"K Bj\u00f6rk","year":"2006","unstructured":"Bj\u00f6rk K, Saarikoski ST, Arlinde C, Kovanen L, Osei-Hyiaman D, Ubaldi M et al (2006) Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity. FASEB J 20:1826\u20131835","journal-title":"FASEB J"},{"key":"1252_CR8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.canlet.2005.04.033","volume":"235","author":"PN Chen","year":"2006","unstructured":"Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL, Hsieh YS (2006) Mulberry anthocyanins, cyanidin 3-rutinoside and cyaniding 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235:248\u2013259","journal-title":"Cancer Lett"},{"key":"1252_CR9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0304-3940(03)00637-2","volume":"347","author":"JT Cheng","year":"2003","unstructured":"Cheng JT, Kuo DY (2003) Both \u03b11-adrenergic and D1-dopaminergic neurotransmissions are involved in phenylpropanolamine-mediated feeding suppression in mice. Neurosci Lett 347:136\u2013138","journal-title":"Neurosci Lett"},{"key":"1252_CR10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"P Chomczynski","year":"1987","unstructured":"Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid quanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156\u2013159","journal-title":"Anal Biochem"},{"key":"1252_CR11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis (Review). Free Radic Biol Med 48:749\u2013762","journal-title":"Free Radic Biol Med"},{"key":"1252_CR12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","volume":"411","author":"MA Cowley","year":"2001","unstructured":"Cowley MA, Smart JL, Rubinstein M, Cerd\u00e1n MG, Diano S, Horvath TL et al (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480\u2013484","journal-title":"Nature"},{"key":"1252_CR13","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nm.2421","volume":"17","author":"S Diano","year":"2011","unstructured":"Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E et al (2011) Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med 17:1121\u20131127","journal-title":"Nat Med"},{"key":"1252_CR14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/REVNEURO.2008.19.4-5.341","volume":"19","author":"S Dziennis","year":"2008","unstructured":"Dziennis S, Alkayed NJ (2008) Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Rev Neurosci 19:341\u2013361","journal-title":"Rev Neurosci"},{"key":"1252_CR15","doi-asserted-by":"crossref","first-page":"11582","DOI":"10.1523\/JNEUROSCI.5712-08.2009","volume":"29","author":"MB Ernst","year":"2009","unstructured":"Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB et al (2009) Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci 29:11582\u201311593","journal-title":"J Neurosci"},{"key":"1252_CR16","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1093\/nar\/21.24.5761","volume":"21","author":"MK Ghosh","year":"1993","unstructured":"Ghosh MK, Ghosh K, Dahl O, Cohen JS (1993) Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application. Nucleic Acids Res 21:5761\u20135766","journal-title":"Nucleic Acids Res"},{"key":"1252_CR17","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1210\/en.2007-0945","volume":"149","author":"L Gong","year":"2008","unstructured":"Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K et al (2008) Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein\/neuropeptide Y neurons for normal energy homeostasis. Endocrinology 149:3346\u20133354","journal-title":"Endocrinology"},{"key":"1252_CR18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tem.2008.10.003","volume":"20","author":"TL Horvath","year":"2009","unstructured":"Horvath TL, Andrews ZB, Diano S (2009) Fuel utilization by hypothalamic neurons: roles for ROS. Trends Endocrinol Metab 20:78\u201387","journal-title":"Trends Endocrinol Metab"},{"key":"1252_CR19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1152\/physiolgenomics.00110.2007","volume":"31","author":"YS Hsieh","year":"2007","unstructured":"Hsieh YS, Yang SF, Chu SC, Kuo DY (2007a) Transcript of protein kinase A knock down modulates feeding behavior and neuropeptide Y gene expression in phenylpropanolamine-treated rats. Physiol Genomics 31:306\u2013314","journal-title":"Physiol Genomics"},{"key":"1252_CR20","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1037\/0735-7044.121.5.933","volume":"121","author":"YS Hsieh","year":"2007","unstructured":"Hsieh YS, Yang SF, Chiou HL, Kuo DY (2007b) Roles of central catecholamine and hypothalamic neuropeptide Y genome in the development of tolerance to phenylpropanolamine-mediated appetite suppression. Behav Neurosci 121:933\u2013940","journal-title":"Behav Neurosci"},{"key":"1252_CR21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1471-4159.2007.04919.x","volume":"104","author":"YS Hsieh","year":"2008","unstructured":"Hsieh YS, Yang SF, Chu SC, Kuo DY (2008) Interrupting activator protein-1 signaling in conscious rats can modify neuropeptide Y gene expression and feeding behavior of phenylpropanolamine. J Neurochem 104:50\u201361","journal-title":"J Neurochem"},{"key":"1252_CR22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2013.05.005","volume":"64","author":"YH Hsieh","year":"2013","unstructured":"Hsieh YH, Chen PN, Yu CH, Liao JM, Kuo DY (2013a) Inhibiting neuropeptide Y Y1 receptor modulates melanocortin receptor- and NFkB-mediated feeding behavior in phenylpropanolamine-treated rats. Horm Behav 64:95\u2013102","journal-title":"Horm Behav"},{"key":"1252_CR23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00204-012-0947-7","volume":"87","author":"YS Hsieh","year":"2013","unstructured":"Hsieh YS, Chen PN, Kuo MS, Kuo DY (2013b) Neuropeptide Y Y1 receptor knockdown can modify glutathione peroxidase and c-AMP response element binding protein in phenylpropanolamine-treated rats. Arch Toxicol 87:469\u2013479","journal-title":"Arch Toxicol"},{"key":"1252_CR24","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/db08-1039","volume":"58","author":"T Jaillard","year":"2009","unstructured":"Jaillard T, Roger M, Galinier A, Guillou P, Benani A, Leloup C et al (2009) Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism. Diabetes 58:1544\u20131549","journal-title":"Diabetes"},{"key":"1252_CR25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00011-011-0335-4","volume":"60","author":"KD Ju","year":"2011","unstructured":"Ju KD, Lim JW, Kim KH, Kim H (2011) Potential role of NADPH oxidase-mediated activation of Jak2\/Stat3 and mitogen-activated protein kinases and expression of TGF-\u03b21 in the pathophysiology of acute pancreatitis. Inflamm Res 60:791\u2013800","journal-title":"Inflamm Res"},{"key":"1252_CR26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000048208","volume":"9","author":"DY Kuo","year":"2002","unstructured":"Kuo DY (2002) Co-administration of dopamine D1 and D2 agonists additively decreases daily food intake, body weight and hypothalamic neuropeptide Y level. J Biomed Sci 9:126\u2013132","journal-title":"J Biomed Sci"},{"key":"1252_CR27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0168-0102(02)00086-X","volume":"44","author":"DY Kuo","year":"2002","unstructured":"Kuo DY, Cheng JT (2002) Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine. Neurosci Res 44:63\u201369","journal-title":"Neurosci Res"},{"key":"1252_CR28","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1471-4159.2009.05909.x","volume":"108","author":"DY Kuo","year":"2009","unstructured":"Kuo DY, Yang SF, Chu SC, Chen CH, Hsieh YS (2009a) Roles of protein kinase C-\u03b1 isozyme in the regulation of oxidative stress and neuropeptide Y gene expression in phenylpropanolamine-mediated appetite suppression. J Neurochem 108:1495\u20131506","journal-title":"J Neurochem"},{"key":"1252_CR29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cbi.2009.03.013","volume":"180","author":"DY Kuo","year":"2009","unstructured":"Kuo DY, Yang SF, Chu SC, Chen CH, Hsieh YS (2009b) Amphetamine-evoked changes of oxidative stress and neuropeptide Y gene expression in hypothalamus: regulation by the protein kinase C-delta signaling. Chem Biol Interact 180:193\u2013201","journal-title":"Chem Biol Interact"},{"key":"1252_CR30","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1471-4159.2010.06843.x","volume":"114","author":"DY Kuo","year":"2010","unstructured":"Kuo DY, Yang SF, Chu SC, Chen CH, Chen PN, Hsieh YS (2010) The effect of protein kinase C-delta knockdown on anti-free radical enzyme and neuropeptide Y gene expression in phenylpropanolamine-treated rats. J Neurochem 114:1217\u20131230","journal-title":"J Neurochem"},{"key":"1252_CR31","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1089\/ars.2010.3738","volume":"15","author":"DY Kuo","year":"2011","unstructured":"Kuo DY, Chen PN, Yang SF, Chu SC, Chen CH, Kuo MS, Yu CH, Hsieh YS (2011) Role of reactive oxygen species-related enzymes in neuropeptide Y and proopiomelanocortin-mediated appetite control: a study using atypical protein kinase C knockdown. Antioxid Redox Signal 15:2147\u20132159","journal-title":"Antioxid Redox Signal"},{"key":"1252_CR32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00204-011-0761-7","volume":"86","author":"DY Kuo","year":"2012","unstructured":"Kuo DY, Chen PN, Chu SC, Hsieh YS (2012a) Knocking down the transcript of NF-kappaB modulates the reciprocal regulation of endogenous antioxidants and feeding behavior in phenylpropanolamine-treated rats. Arch Toxicol 86:453\u2013463","journal-title":"Arch Toxicol"},{"key":"1252_CR33","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.neuropharm.2011.11.014","volume":"62","author":"DY Kuo","year":"2012","unstructured":"Kuo DY, Chen PN, Kuo MH, Chen CH, Hsieh YS, Chu SC (2012b) NF-kappaB knockdown can modulate amphetamine-mediated feeding response. Neuropharmacology 62:1684\u20131694","journal-title":"Neuropharmacology"},{"key":"1252_CR34","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.2337\/db06-0086","volume":"55","author":"C Leloup","year":"2006","unstructured":"Leloup C, Magnan C, Benani A, Bonnet E, Alquier T, Offer G et al (2006) Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes 55:2084\u20132090","journal-title":"Diabetes"},{"key":"1252_CR35","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1158\/0008-5472.CAN-10-0894","volume":"70","author":"L Li","year":"2010","unstructured":"Li L, Cheung SH, Evans EL, Shaw PE (2010) Modulation of gene expression and tumor cell growth by redox modification of STAT3. Cancer Res 70:8222\u20138232","journal-title":"Cancer Res"},{"key":"1252_CR36","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jocn.2013.03.006","volume":"20","author":"RB Luwor","year":"2013","unstructured":"Luwor RB, Stylli SS, Kaye AH (2013) The role of Stat3 in glioblastoma multiforme. J Clin Neurosci 20:907\u2013911","journal-title":"J Clin Neurosci"},{"key":"1252_CR37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/cne.902900305","volume":"290","author":"BJ Morris","year":"1989","unstructured":"Morris BJ (1989) Neuronal localization of neuropeptide Y gene expression in rat brain. J Comp Neurol 290:358\u2013368","journal-title":"J Comp Neurol"},{"key":"1252_CR38","doi-asserted-by":"crossref","first-page":"E1051","DOI":"10.1152\/ajpendo.00094.2005","volume":"289","author":"CD Morrison","year":"2005","unstructured":"Morrison CD, Morton GJ, Niswender KD, Gelling RW, Schwartz MW (2005) Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 289:E1051\u2013E1057","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"1252_CR39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/chemse\/23.2.249","volume":"23","author":"S Ogawa","year":"1998","unstructured":"Ogawa S, Pfaff DW (1998) Current status of antisense DNA methods in behavioral studies. Chem Senses 23:249\u2013255","journal-title":"Chem Senses"},{"key":"1252_CR40","doi-asserted-by":"crossref","unstructured":"Parsons AC, Shraim M, Inglis J, Aveyard P, Hajek P (2009) Interventions for preventing weight gain after smoking cessation. Cochrane Database Syst Rev 1:CD006219. Review","DOI":"10.1002\/14651858.CD006219.pub2"},{"key":"1252_CR41","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, Sydney","edition":"2"},{"key":"1252_CR42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1369-1600.2008.00101.x","volume":"13","author":"JH Penzner","year":"2008","unstructured":"Penzner JH, Thompson DL, Arth C, Fowler JK, Ary AW, Szumlinski KK (2008) Protracted \u2018anti-addictive\u2019 effects of adolescent phenylpropanolamine exposure in C57BL\/6J mice. Addict Biol 13:310\u2013325","journal-title":"Addict Biol"},{"key":"1252_CR43","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1113\/jphysiol.2009.176156","volume":"587","author":"A Plagemann","year":"2009","unstructured":"Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M et al (2009) Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 587:4963\u20134976","journal-title":"J Physiol"},{"key":"1252_CR44","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2119\/molmed.2010.00259","volume":"17","author":"P Rajan","year":"2011","unstructured":"Rajan P (2011) STATus and context within the mammalian nervous system. Mol Med 17:965\u2013973","journal-title":"Mol Med"},{"key":"1252_CR45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1126\/science.6264602","volume":"213","author":"RC Ritter","year":"1981","unstructured":"Ritter RC, Slusser PG, Stone S (1981) Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451\u2013452","journal-title":"Science"},{"key":"1252_CR46","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuroscience.2007.10.041","volume":"151","author":"L Shao","year":"2008","unstructured":"Shao L, Cui J, Young LT, Wang JF (2008) The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience 151:518\u2013524","journal-title":"Neuroscience"},{"key":"1252_CR47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/152308604322899350","volume":"6","author":"R Sharma","year":"2004","unstructured":"Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi YC (2004) Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal 6:289\u2013300","journal-title":"Antioxid Redox Signal"},{"key":"1252_CR48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/34.5.3517144","volume":"34","author":"LA Sternberger","year":"1986","unstructured":"Sternberger LA, Sternberger NH (1986) The unlabeled antibody method: comparison of peroxidase\u2013antiperoxidase with avidin-biotin complex by a new method of quantification. J Histochem Cytochem 34:509\u2013605","journal-title":"J Histochem Cytochem"},{"key":"1252_CR49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.eururo.2007.09.037","volume":"53","author":"P Tsakiris","year":"2008","unstructured":"Tsakiris P, de la Rosette JJ, Michel MC, Oelke M (2008) Pharmacologic treatment of male stress urinary incontinence: systematic review of the literature and levels of evidence. Eur Urol 53:53\u201359","journal-title":"Eur Urol"},{"key":"1252_CR50","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","volume":"82","author":"Z Wen","year":"1995","unstructured":"Wen Z, Zhong Z, Darnell JE Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241\u2013250","journal-title":"Cell"},{"key":"1252_CR51","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1210\/en.2006-1119","volume":"148","author":"AW Xu","year":"2007","unstructured":"Xu AW, Ste-Marie L, Kaelin CB, Barsh GS (2007) Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology 148:72\u201380","journal-title":"Endocrinology"},{"key":"1252_CR52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/jpi.12070","volume":"55","author":"Y Yang","year":"2013","unstructured":"Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z, Li Y, Chen W, Yi D, Yu S (2013) JAK2\/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia\/reperfusion injury. J Pineal Res 55:275\u2013286","journal-title":"J Pineal Res"},{"key":"1252_CR53","doi-asserted-by":"crossref","first-page":"e55839","DOI":"10.1371\/journal.pone.0055839","volume":"8","author":"L Yu","year":"2013","unstructured":"Yu L, Chen C, Wang LF, Kuang X, Liu K, Zhang H, Du JR (2013) Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-\u03baB and STAT3 in transient focal stroke. PLoS One 8:e55839","journal-title":"PLoS One"},{"key":"1252_CR55","doi-asserted-by":"crossref","first-page":"e43313","DOI":"10.1371\/journal.pone.0043313","volume":"7","author":"C Zgheib","year":"2012","unstructured":"Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J et al (2012) Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS One 7:e43313","journal-title":"PLoS One"},{"key":"1252_CR56","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0304-3940(93)90299-Z","volume":"161","author":"M Zhang","year":"1993","unstructured":"Zhang M, Creese I (1993) Antisense oligodeoxynucleotide reduces brain dopamine D2 receptors: behavioral correlates. Neurosci Lett 161:223\u2013226","journal-title":"Neurosci Lett"},{"key":"1252_CR57","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.8140422","volume":"264","author":"Z Zhong","year":"1994","unstructured":"Zhong Z, Wen Z, Darnell JE Jr (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95\u201398","journal-title":"Science"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1252-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-014-1252-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1252-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T09:24:29Z","timestamp":1716715469000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-014-1252-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,4]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["1252"],"URL":"https:\/\/doi.org\/10.1007\/s00204-014-1252-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,4]]}}}