{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:17:27Z","timestamp":1793326647497,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00204-014-1322-7","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T21:15:36Z","timestamp":1407186936000},"page":"1569-1578","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Activation of sterol regulatory element-binding proteins in mice exposed to perfluorooctanoic acid for 28\u00a0days"],"prefix":"10.1007","volume":"89","author":[{"given":"Shengmin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"issue":"2","key":"1322_CR1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215\u2013233","journal-title":"Cell"},{"issue":"2","key":"1322_CR2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ceb.2007.02.004","volume":"19","author":"MT Bengoechea-Alonso","year":"2007","unstructured":"Bengoechea-Alonso MT, Ericsson J (2007) SREBP in signal transduction: cholesterol metabolism and beyond. Curr Opin Cell Biol 19(2):215\u2013222","journal-title":"Curr Opin Cell Biol"},{"issue":"1\u20133","key":"1322_CR3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2011.06.012","volume":"288","author":"JA Bjork","year":"2011","unstructured":"Bjork JA, Butenhoff JL, Wallace KB (2011) Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes. Toxicology 288(1\u20133):8\u201317","journal-title":"Toxicology"},{"issue":"3","key":"1322_CR4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2013.06.004","volume":"18","author":"O Dumortier","year":"2013","unstructured":"Dumortier O, Hinault C, Van Obberghen E (2013) MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab 18(3):312\u2013324","journal-title":"Cell Metab"},{"issue":"10","key":"1322_CR5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00204-012-0877-4","volume":"86","author":"X Fang","year":"2012","unstructured":"Fang X, Zou S, Zhao Y et al (2012) Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor alpha expression by releasing cytokines. Arch Toxicol 86(10):1515\u20131525","journal-title":"Arch Toxicol"},{"issue":"24","key":"1322_CR6","doi-asserted-by":"crossref","first-page":"21466","DOI":"10.1074\/jbc.M110.209973","volume":"286","author":"A Fernandez-Alvarez","year":"2011","unstructured":"Fernandez-Alvarez A, Alvarez MS, Gonzalez R, Cucarella C, Muntane J, Casado M (2011) Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 286(24):21466\u201321477","journal-title":"J Biol Chem"},{"issue":"6","key":"1322_CR7","doi-asserted-by":"crossref","first-page":"e65641","DOI":"10.1371\/journal.pone.0065641","volume":"8","author":"M Gao","year":"2013","unstructured":"Gao M, Bu L, Ma Y, Liu D (2013) Concurrent activation of liver X receptor and peroxisome proliferator-activated receptor alpha exacerbates hepatic steatosis in high fat diet-induced obese mice. PLoS ONE 8(6):e65641","journal-title":"PLoS ONE"},{"issue":"1","key":"1322_CR8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0005-2760(92)90258-W","volume":"1128","author":"B Haughom","year":"1992","unstructured":"Haughom B, Spydevold O (1992) The mechanism underlying the hypolipemic effect of perfluorooctanoic acid (PFOA), perfluorooctane sulphonic acid (PFOSA) and clofibric acid. Biochim Biophys Acta 1128(1):65\u201372","journal-title":"Biochim Biophys Acta"},{"key":"1322_CR9","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1042\/bst0301091","volume":"30","author":"JD Horton","year":"2002","unstructured":"Horton JD (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc T 30:1091\u20131095","journal-title":"Biochem Soc T"},{"issue":"9","key":"1322_CR10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109(9):1125\u20131131","journal-title":"J Clin Invest"},{"issue":"2","key":"1322_CR11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tem.2011.10.004","volume":"23","author":"TI Jeon","year":"2012","unstructured":"Jeon TI, Osborne TF (2012) SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab 23(2):65\u201372","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"1322_CR12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2013.06.010","volume":"18","author":"TI Jeon","year":"2013","unstructured":"Jeon TI, Esquejo RM, Roqueta-Rivera M et al (2013) An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. Cell Metab 18(1):51\u201361","journal-title":"Cell Metab"},{"issue":"4","key":"1322_CR13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/10408440490464705","volume":"34","author":"GL Kennedy Jr","year":"2004","unstructured":"Kennedy GL Jr, Butenhoff JL, Olsen GW et al (2004) The toxicology of perfluorooctanoate. Crit Rev Toxicol 34(4):351\u2013384","journal-title":"Crit Rev Toxicol"},{"issue":"6785","key":"1322_CR14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/35013000","volume":"405","author":"S Kersten","year":"2000","unstructured":"Kersten S, Desvergne B, Wahli W (2000) Roles of PPARs in health and disease. Nature 405(6785):421\u2013424","journal-title":"Nature"},{"issue":"Pt 2","key":"1322_CR15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/BJ20041896","volume":"389","author":"BL Knight","year":"2005","unstructured":"Knight BL, Hebbachi A, Hauton D et al (2005) A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver. Biochem J 389(Pt 2):413\u2013421","journal-title":"Biochem J"},{"issue":"1\u20133","key":"1322_CR16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2009.01.009","volume":"605","author":"B Konig","year":"2009","unstructured":"Konig B, Koch A, Spielmann J et al (2009) Activation of PPAR alpha and PPAR gamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1. Eur J Pharmacol 605(1\u20133):23\u201330","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1322_CR17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0009-2797(99)00002-2","volume":"118","author":"N Kudo","year":"1999","unstructured":"Kudo N, Mizuguchi H, Yamamoto A, Kawashima Y (1999) Alterations by perfluorooctanoic acid of glycerolipid metabolism in rat liver. Chem Biol Interact 118(1):69\u201383","journal-title":"Chem Biol Interact"},{"issue":"2","key":"1322_CR18","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","volume":"99","author":"C Lau","year":"2007","unstructured":"Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99(2):366\u2013394","journal-title":"Toxicol Sci"},{"issue":"10","key":"1322_CR19","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1101\/gad.891301","volume":"15","author":"M Matsuda","year":"2001","unstructured":"Matsuda M, Korn BS, Hammer RE et al (2001) SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Gene Dev 15(10):1206\u20131216","journal-title":"Gene Dev"},{"issue":"1","key":"1322_CR20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2486\/indhealth.48.96","volume":"48","author":"M Minata","year":"2010","unstructured":"Minata M, Harada KH, Karrman A et al (2010) Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver. Ind Health 48(1):96\u2013107","journal-title":"Ind Health"},{"issue":"15","key":"1322_CR21","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1101\/gad.916601","volume":"15","author":"TF Osborne","year":"2001","unstructured":"Osborne TF (2001) CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin. Gene Dev 15(15):1873\u20131878","journal-title":"Gene Dev"},{"key":"1322_CR22","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.08002","volume":"8","author":"SR Pyper","year":"2010","unstructured":"Pyper SR, Viswakarma N, Yu S, Reddy JK (2010) PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. Nucl Recept Signal 8:e002","journal-title":"Nucl Recept Signal"},{"issue":"2","key":"1322_CR23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tem.2007.10.009","volume":"19","author":"R Raghow","year":"2008","unstructured":"Raghow R, Yellaturu C, Deng X, Park EA, Elam MB (2008) SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Metab 19(2):65\u201373","journal-title":"Trends Endocrinol Metab"},{"issue":"4","key":"1322_CR24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0192623308318208","volume":"36","author":"MB Rosen","year":"2008","unstructured":"Rosen MB, Abbott BD, Wolf DC et al (2008a) Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid. Toxicol Pathol 36(4):592\u2013607","journal-title":"Toxicol Pathol"},{"issue":"1","key":"1322_CR25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/toxsci\/kfn025","volume":"103","author":"MB Rosen","year":"2008","unstructured":"Rosen MB, Lee JS, Ren H et al (2008b) Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol Sci 103(1):46\u201356","journal-title":"Toxicol Sci"},{"key":"1322_CR26","doi-asserted-by":"crossref","unstructured":"Rosen MB, Schmid JR, Corton JC, et al. (2010) Gene Expression Profiling in Wild-Type and PPARalpha-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARalpha-Independent Effects. PPAR Res 2010, pii:794739","DOI":"10.1155\/2010\/794739"},{"issue":"2","key":"1322_CR27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.toxlet.2012.05.007","volume":"212","author":"E Scharmach","year":"2012","unstructured":"Scharmach E, Buhrke T, Lichtenstein D, Lampen A (2012) Perfluorooctanoic acid affects the activity of the hepatocyte nuclear factor 4 alpha (HNF4alpha). Toxicol Lett 212(2):106\u2013112","journal-title":"Toxicol Lett"},{"issue":"4","key":"1322_CR28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2012.09.002","volume":"16","author":"W Shao","year":"2012","unstructured":"Shao W, Espenshade PJ (2012) Expanding roles for SREBP in metabolism. Cell Metab 16(4):414\u2013419","journal-title":"Cell Metab"},{"issue":"1","key":"1322_CR29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfl135","volume":"95","author":"ML Takacs","year":"2007","unstructured":"Takacs ML, Abbott BD (2007) Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta\/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate. Toxicol Sci 95(1):108\u2013117","journal-title":"Toxicol Sci"},{"issue":"4","key":"1322_CR30","doi-asserted-by":"crossref","first-page":"e61409","DOI":"10.1371\/journal.pone.0061409","volume":"8","author":"X Tan","year":"2013","unstructured":"Tan X, Xie G, Sun X et al (2013) High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways. PLoS ONE 8(4):e61409","journal-title":"PLoS ONE"},{"issue":"8","key":"1322_CR31","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","volume":"1812","author":"T Varga","year":"2011","unstructured":"Varga T, Czimmerer Z, Nagy L (2011) PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta 1812(8):1007\u20131022","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"1322_CR32","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.bbagen.2012.03.010","volume":"1820","author":"HT Wan","year":"2012","unstructured":"Wan HT, Zhao YG, Wei X, Hui KY, Giesy JP, Wong CK (2012) PFOS-induced hepatic steatosis, the mechanistic actions on beta-oxidation and lipid transport. Biochim Biophys Acta 1820(7):1092\u20131101","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"1322_CR33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/0192623308318216","volume":"36","author":"DC Wolf","year":"2008","unstructured":"Wolf DC, Moore T, Abbott BD et al (2008) Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice. Toxicol Pathol 36(4):632\u2013639","journal-title":"Toxicol Pathol"},{"issue":"1","key":"1322_CR34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.toxlet.2013.10.017","volume":"224","author":"S Yan","year":"2014","unstructured":"Yan S, Wang J, Zhang W, Dai J (2014) Circulating MicroRNA profiles altered in mice after 28\u00a0days exposure to perfluorooctanoic acid. Toxicol Lett 224(1):24\u201331","journal-title":"Toxicol Lett"},{"issue":"7","key":"1322_CR35","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1210\/me.2002-0190","volume":"17","author":"T Yoshikawa","year":"2003","unstructured":"Yoshikawa T, Ide T, Shimano H et al (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Mol Endocrinol 17(7):1240\u20131254","journal-title":"Mol Endocrinol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1322-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-014-1322-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1322-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T15:17:03Z","timestamp":1558624623000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-014-1322-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["1322"],"URL":"https:\/\/doi.org\/10.1007\/s00204-014-1322-7","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]}}}