{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:42:41Z","timestamp":1788925361919,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00204-014-1331-6","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T11:38:01Z","timestamp":1408534681000},"page":"1771-1772","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?"],"prefix":"10.1007","volume":"88","author":[{"given":"Albert","family":"Braeuning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"1331_CR1","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1038\/sj.onc.1204982","volume":"20","author":"H Aydinlik","year":"2001","unstructured":"Aydinlik H, Nguyen TD, Moennikes O, Buchmann A, Schwarz M (2001) Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. Oncogene 20:7812\u20137816","journal-title":"Oncogene"},{"key":"1331_CR2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfr166","volume":"123","author":"A Braeuning","year":"2011","unstructured":"Braeuning A, Heubach Y, Knorpp T, Kowalik MA, Templin M, Columbano A, Schwarz M (2011) Gender-specific interplay of signaling through \u03b2-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation. Toxicol Sci 123:113\u2013122","journal-title":"Toxicol Sci"},{"key":"1331_CR3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/toxsci\/kfu099","volume":"140","author":"A Braeuning","year":"2014","unstructured":"Braeuning A, Gavrilov A, Brown S, Wolf CR, Henderson CJ, Schwarz M (2014) Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. Toxicol Sci 140:259\u2013270","journal-title":"Toxicol Sci"},{"key":"1331_CR4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3109\/10408444.2013.835786","volume":"44","author":"CR Elcombe","year":"2014","unstructured":"Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D et al (2014) Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: a case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol 44:64\u201382","journal-title":"Crit Rev Toxicol"},{"key":"1331_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/toxsci\/kfj001","volume":"89","author":"MP Holsapple","year":"2006","unstructured":"Holsapple MP, Pitot HC, Cohen SM, Boobis AR, Klaunig JE, Pastoor T et al (2006) Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol Sci 89:51\u201356","journal-title":"Toxicol Sci"},{"key":"1331_CR6","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1210\/me.2004-0520","volume":"19","author":"W Huang","year":"2005","unstructured":"Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD (2005) Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol 19:1646\u20131653","journal-title":"Mol Endocrinol"},{"key":"1331_CR7","first-page":"161","volume":"79","author":"IARC","year":"2001","unstructured":"IARC (2001) Phenobarbital and its sodium salt. IARC Monogr 79:161\u2013288","journal-title":"IARC Monogr"},{"key":"1331_CR8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.taap.2013.04.009","volume":"270","author":"MJ LeBaron","year":"2013","unstructured":"LeBaron MJ, Geter DR, Rasoulpour RJ, Gollapudi BB, Thomas J, Murray J, Kan HL, Wood AJ, Elcombe C, Vardy A, McEwan J, Terry C, Billington R (2013) An integrated approach for prospectively investigating a mode-of-action for rodent liver effects. Toxicol Appl Pharmacol 270:164\u2013173","journal-title":"Toxicol Appl Pharmacol"},{"key":"1331_CR9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/toxsci\/kfu038","volume":"139","author":"R Luisier","year":"2014","unstructured":"Luisier R, Lempi\u00e4inen H, Scherbichler N, Braeuning A, Geissler M, Dubost V et al (2014) Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane X receptors. Toxicol Sci 139:501\u2013511","journal-title":"Toxicol Sci"},{"key":"1331_CR10","first-page":"1143","volume":"51","author":"W Parzefall","year":"1991","unstructured":"Parzefall W, Erber E, Sedivy R, Schulte-Hermann R (1991) Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters. Cancer Res 51:1143\u20131147","journal-title":"Cancer Res"},{"key":"1331_CR11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/carcin\/bgq226","volume":"32","author":"B Rignall","year":"2011","unstructured":"Rignall B, Braeuning A, Buchmann A, Schwarz M (2011) Tumor formation in liver of conditional \u03b2-catenin-deficient mice exposed to a diethylnitrosamine\/phenobarbital tumor promotion regimen. Carcinogenesis 32:52\u201357","journal-title":"Carcinogenesis"},{"key":"1331_CR12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/toxsci\/kfq118","volume":"116","author":"J Ross","year":"2010","unstructured":"Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR (2010) Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. Toxicol Sci 116:452\u2013466","journal-title":"Toxicol Sci"},{"key":"1331_CR13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/03602532.2012.738687","volume":"45","author":"N Scheer","year":"2013","unstructured":"Scheer N, Wolf CR (2013) Xenobiotic receptor humanized mice and their utility. Drug Metab Rev 45:110\u2013121","journal-title":"Drug Metab Rev"},{"key":"1331_CR14","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1172\/JCI35483","volume":"118","author":"N Scheer","year":"2008","unstructured":"Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR (2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Investig 118:3228\u20133239","journal-title":"J Clin Investig"},{"key":"1331_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0163-7258(96)00067-8","volume":"71","author":"J Whysner","year":"1996","unstructured":"Whysner J, Ross PM, Williams GM (1996) Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol Ther 71:153\u2013191","journal-title":"Pharmacol Ther"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1331-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-014-1331-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-014-1331-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:17:03Z","timestamp":1558639023000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-014-1331-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,21]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["1331"],"URL":"https:\/\/doi.org\/10.1007\/s00204-014-1331-6","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,21]]}}}