{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:10:22Z","timestamp":1792411822363,"version":"4.4.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,1,25]],"date-time":"2015-01-25T00:00:00Z","timestamp":1422144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s00204-015-1456-2","type":"journal-article","created":{"date-parts":[[2015,1,24]],"date-time":"2015-01-24T14:31:41Z","timestamp":1422109901000},"page":"327-334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Drug-induced liver injury: an overview over the most critical compounds"],"prefix":"10.1007","volume":"89","author":[{"given":"Einar S.","family":"Bj\u00f6rnsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,25]]},"reference":[{"key":"1456_CR1","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/hep.20205","volume":"39","author":"GP Aithal","year":"2004","unstructured":"Aithal GP, Ramsay L, Daly AK, Sonchit N, Leathart JB, Alexander G, Kenna JG, Caldwell J, Day CP (2004) Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity. Hepatology 39:1430\u20131440","journal-title":"Hepatology"},{"key":"1456_CR2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/clpt.2011.58","volume":"89","author":"GP Aithal","year":"2011","unstructured":"Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H et al (2011) Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther 89:806\u2013815","journal-title":"Clin Pharmacol Ther"},{"key":"1456_CR3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.gastro.2005.05.006","volume":"129","author":"RJ Andrade","year":"2005","unstructured":"Andrade RJ, Lucena MI, Fernandez MC et al (2005) Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology 129:512\u2013521","journal-title":"Gastroenterology"},{"key":"1456_CR4","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0895-4356(93)90102-7","volume":"46","author":"C Benichou","year":"1993","unstructured":"Benichou C, Danan G, Flahault A (1993) Causality assessment of adverse reactions to drugs-II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 46:1331\u20131336","journal-title":"J Clin Epidemiol"},{"key":"1456_CR5","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.20800","volume":"42","author":"E Bj\u00f6rnsson","year":"2005","unstructured":"Bj\u00f6rnsson E, Olsson R (2005) Outcome and prognostic markers in severe drug-induced liver disease. Hepatology 42:481\u2013489","journal-title":"Hepatology"},{"key":"1456_CR01","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jhep.2008.10.021","volume":"50","author":"E Bj\u00f6rnsson","year":"2009","unstructured":"Bj\u00f6rnsson E, Davidsdottir L (2009) The long-term follow-up after idiosyncratic drug-induced liver injury with jaundice. J Hepatology 50:511\u2013517","journal-title":"J Hepatology"},{"key":"1456_CR6","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1111\/j.1365-2036.2007.03330.x","volume":"25","author":"E Bj\u00f6rnsson","year":"2007","unstructured":"Bj\u00f6rnsson E, Kalaitzakis E, Olsson R (2007) The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury. Aliment Pharmacol Ther 25:1411\u20131421","journal-title":"Aliment Pharmacol Ther"},{"key":"1456_CR7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jhep.2011.07.023","volume":"56","author":"E Bj\u00f6rnsson","year":"2012","unstructured":"Bj\u00f6rnsson E, Jacobsen EI, Kalaitzakis E (2012) Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. J Hepatol 56:374\u2013380","journal-title":"J Hepatol"},{"key":"1456_CR8","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1053\/j.gastro.2013.02.006","volume":"144","author":"ES Bj\u00f6rnsson","year":"2013","unstructured":"Bj\u00f6rnsson ES, Bergmann OM, Bjornsson HK, Kvaran RB, Olafsson S (2013) Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology 144:1419\u20131425","journal-title":"Gastroenterology"},{"key":"1456_CR02","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rnsson ES, Gunnarsson BI, Gr\u00f6ndal G, Jonasson JG, Einarsdottir R, Ludviksson BR, Gudbj\u00f6rnsson B, Olafsson O (2014) The risk of drug-induced liver injury from Tumor Necrosis Factor (TNF)-alpha-antagonists. Clin Gastroenterol Hepatol. doi: 10.1016\/j.cgh.2014.07.062","DOI":"10.1016\/j.cgh.2014.07.062"},{"key":"1456_CR9","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1053\/j.gastro.2008.09.011","volume":"135","author":"N Chalasani","year":"2008","unstructured":"Chalasani N, Fontana RJ, Bonkovsky HL et al (2008) Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 135:1924\u20131934","journal-title":"Gastroenterology"},{"key":"1456_CR10","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.amjmed.2005.02.008","volume":"118","author":"EC Charles","year":"2005","unstructured":"Charles EC, Olson KL, Sandhoff BG, McClure DL, Merenich JA (2005) Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization. Am J Med 118:618\u2013624","journal-title":"Am J Med"},{"key":"1456_CR11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ng.379","volume":"41","author":"AK Daly","year":"2009","unstructured":"Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe\u2019er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP (2009) Nat Genet 41:816\u2013819","journal-title":"Nat Genet"},{"key":"1456_CR12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/0895-4356(93)90101-6","volume":"46","author":"G Danan","year":"1993","unstructured":"Danan G, Benichou C (1993) Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 46:1323\u20131330","journal-title":"J Clin Epidemiol"},{"key":"1456_CR13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0168-8278(05)80476-3","volume":"20","author":"MH Davies","year":"1994","unstructured":"Davies MH, Harrison RF, Elias E, H\u00fcbscher SG (1994) Antibiotic-associated acute vanishing bile duct syndrome: a pattern associated with severe, prolonged, intrahepatic cholestasis. J Hepatol 20:112\u2013116","journal-title":"J Hepatol"},{"issue":"1","key":"1456_CR14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2125.2004.02133.x","volume":"58","author":"FJ Abajo de","year":"2004","unstructured":"de Abajo FJ, Montero D, Madurga M, de Garc\u00eda Rodr\u00edguez LA (2004) Acute and clinically relevant drug-induced liver injury: a population based case-control study. Br J Clin Pharmacol 58(1):71\u201380","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"1456_CR15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2036.2006.03117.x","volume":"24","author":"MB Valle De","year":"2006","unstructured":"De Valle MB, Av Klinteberg V, Alem N, Olsson R, Bj\u00f6rnsson E (2006) Drug induced liver injury in a Swedish University hospital out-patient hepatology clinic. Aliment Pharmacol Ther 24(8):1187\u20131195","journal-title":"Aliment Pharmacol Ther"},{"key":"1456_CR16","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1038\/ajg.2010.287","volume":"105","author":"H Devarbhavi","year":"2010","unstructured":"Devarbhavi H, Dierkhising R, Kremers WK, Sandeep MS, Karanth D, Adarsh CK (2010) Single-center experience with drug-induced liver injury from India: causes, outcome, prognosis, and predictors of mortality. Am J Gastroenterol 105:2396\u20132404","journal-title":"Am J Gastroenterol"},{"key":"1456_CR17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/bmj.306.6872.233","volume":"306","author":"CK Fairley","year":"1993","unstructured":"Fairley CK, McNeil JJ, Desmond P, Smallwood R, Young H, Forbes A, Purcell P, Boyd I (1993) Risk factors for development of flucloxacillin associated jaundice. BMJ 306:233\u2013235","journal-title":"BMJ"},{"key":"1456_CR18","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s10620-005-2938-5","volume":"50","author":"RJ Fontana","year":"2005","unstructured":"Fontana RJ, Shakil AO, Greenson JK, Boyd I, Lee WM (2005) Acute liver failure due to amoxicillin and amoxicillin\/clavulanate. Dig Dis Sci 50:1785\u20131790","journal-title":"Dig Dis Sci"},{"key":"1456_CR03","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/hep.23696","volume":"52","author":"R Fontana","year":"2010","unstructured":"Fontana R, Seef LB, Andrade RJ, Bjornsson E, Day CP, Serrano J, Hoofnagle JH (2010) Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop. Hepatology 52:730\u2013742","journal-title":"Hepatology"},{"issue":"1","key":"1456_CR19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/j.gastro.2014.03.045","volume":"147","author":"RJ Fontana","year":"2014","unstructured":"Fontana RJ, Hayashi PH, Gu J, Reddy KR, Barnhart H, Watkins PB, Serrano J, Lee WM, Chalasani N, Stolz A, Davern T, Talwakar JA (2014) Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset. Gastroenterology 147(1):96\u2013108","journal-title":"Gastroenterology"},{"key":"1456_CR20","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1001\/archinte.156.12.1327","volume":"156","author":"LA Garc\u00eda Rodr\u00edguez","year":"1996","unstructured":"Garc\u00eda Rodr\u00edguez LA, Stricker BH, Zimmerman HJ (1996) Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Arch Intern Med 156:1327\u20131332","journal-title":"Arch Intern Med"},{"key":"1456_CR21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/j.1875-9114.1997.tb03747.x","volume":"17","author":"LA Garc\u00eda Rodr\u00edguez","year":"1997","unstructured":"Garc\u00eda Rodr\u00edguez LA, Ruig\u00f3mez A, Jick H (1997) A review of epidemiologic research on drug-induced acute liver injury using the general practice research data base in the United Kingdom. Pharmacotherapy 17:721\u2013728","journal-title":"Pharmacotherapy"},{"key":"1456_CR22","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cgh.2012.12.025","volume":"11","author":"M Ghabril","year":"2013","unstructured":"Ghabril M, Bonkovsky HL, Kum C et al (2013) Liver injury from tumor necrosis factor-\u03b1 antagonists: analysis of thirty-four cases. Clin Gastroenterol Hepatol 11:558\u2013564","journal-title":"Clin Gastroenterol Hepatol"},{"key":"1456_CR23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/01.meg.0000250581.77865.68","volume":"19","author":"SH Hussaini","year":"2007","unstructured":"Hussaini SH, O\u2019Brien CS, Despott EJ, Dalton HR (2007) Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Eur J Gastroenterol Hepatol 19:15\u201320","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1456_CR24","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0168-8278(02)00231-3","volume":"37","author":"L Ibanez","year":"2002","unstructured":"Ibanez L, Perez E, Vidal X, Laporte JR (2002) Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases: epidemiological and clinical features, and exposure to drugs. J Hepatol 37:592\u2013600","journal-title":"J Hepatol"},{"key":"1456_CR25","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/hep.22272","volume":"47","author":"C Lammert","year":"2008","unstructured":"Lammert C, Einarsson S, Saha C et al (2008) Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals. Hepatology 47:2003\u20132009","journal-title":"Hepatology"},{"key":"1456_CR26","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1872-034X.2008.00419.x","volume":"38","author":"WM Lee","year":"2008","unstructured":"Lee WM (2008) Acetaminophen-related acute liver failure in the United States. Hepatol Res 38:S3\u2013S8","journal-title":"Hepatol Res"},{"key":"1456_CR27","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/hep.21324","volume":"44","author":"MI Lucena","year":"2006","unstructured":"Lucena MI, Andrade RJ, Fern\u00e1ndez MC, Pachkoria K, Pelaez G, Dur\u00e1n JA et al (2006) Determinants of the clinical expression of amoxicillin\u2013clavulanate hepatotoxicity: a prospective series from Spain. Hepatology 44:850\u2013856","journal-title":"Hepatology"},{"key":"1456_CR28","author":"MA Martinez","year":"2014","unstructured":"Martinez MA, Vuppalanchi R, Fontana RJ, Stolz A, Kleiner DE, Hayashi PH, Gu J, Hoofnagle JH, Chalasani N (2014) Clinical and histologic features of azithromycin-induced liver injury. Clin Gastroenterol Hepatol. doi: 10.1002\/hep.27542","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"1456_CR29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0034-1375958","volume":"34","author":"VJ Navarro","year":"2014","unstructured":"Navarro VJ, Lucena MI (2014) Hepatotoxicity induced by herbal and dietary supplements. Semin Liver Dis 34(2):172\u2013193","journal-title":"Semin Liver Dis"},{"issue":"4","key":"1456_CR30","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hep.27317","volume":"60","author":"VJ Navarro","year":"2014","unstructured":"Navarro VJ, Barnhart H, Bonkovsky HL, Davern T, Fontana RJ, Grant L, Reddy KR, Seeff LB, Serrano J, Sherker AH, Stolz A, Talwalkar J, Vega M, Vuppalanchi R (2014) Liver injury from herbals and dietary supplements in the U.S. drug-induced liver injury network. Hepatology 60(4):1399\u20131408","journal-title":"Hepatology"},{"key":"1456_CR31","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0168-8278(92)90029-O","volume":"15","author":"R Olsson","year":"1992","unstructured":"Olsson R, Wiholm BE, Sand C, Hultcrantz R, Myrhed M (1992) Liver damage from flucloxacillin, cloxacillin and dicloxacillin. J Hepatol 15:154\u2013161","journal-title":"J Hepatol"},{"key":"1456_CR32","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/hep.21359","volume":"44","author":"C Pauli-Magnus","year":"2006","unstructured":"Pauli-Magnus C, Meier PJ (2006) Hepatobiliary transporters and drug-induced cholestasis. Hepatology 44:778\u2013787","journal-title":"Hepatology"},{"key":"1456_CR33","doi-asserted-by":"crossref","unstructured":"P\u00e9rez Gutthann S, Garc\u00eda Rodr\u00edguez LA (1993) The increased risk of hospitalizations for acute liver injury in a population with exposure to multiple drugs. Epidemiology 4(6):496\u2013501","DOI":"10.1097\/00001648-199311000-00004"},{"key":"1456_CR34","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.23937","volume":"52","author":"A Reuben","year":"2010","unstructured":"Reuben A, Koch DG, Lee WM (2010) Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology 52:2065\u20132076","journal-title":"Hepatology"},{"key":"1456_CR35","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/lt.20204","volume":"10","author":"MW Russo","year":"2004","unstructured":"Russo MW, Galanko JA, Shrestha R, Fried MW, Watkins P (2004) Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transpl 10:1018\u20131023","journal-title":"Liver Transpl"},{"key":"1456_CR36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-0029-1240010","volume":"29","author":"MW Russo","year":"2009","unstructured":"Russo MW, Scobey M, Bonkovsky HL (2009) Drug-induced liver injury associated with statins. Review. Semin Liver Dis 29:412\u2013422","journal-title":"Semin Liver Dis"},{"key":"1456_CR37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1053\/jhep.2002.34857","volume":"36","author":"C Sgro","year":"2002","unstructured":"Sgro C, Clinard F, Ouazir K et al (2002) Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 36:451\u2013455","journal-title":"Hepatology"},{"issue":"9","key":"1456_CR38","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/ajg.2012.138","volume":"107","author":"KT Suk","year":"2012","unstructured":"Suk KT, Kim DJ, Kim CH, Park SH, Yoon JH, Kim YS, Baik GH, Kim JB, Kweon YO, Kim BI, Kim SH, Kim IH, Kim JH, Nam SW, Paik YH, Suh JI, Sohn JH, Ahn BM, Um SH, Lee HJ, Cho M, Jang MK, Choi SK, Hwang SG, Sung HT, Choi JY, Han KH (2012) A prospective nationwide study of drug-induced liver injury in Korea. Am J Gastroenterol 107(9):1380\u20131387","journal-title":"Am J Gastroenterol"},{"key":"1456_CR39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2165\/11535340-000000000-00000","volume":"33","author":"A Suzuki","year":"2010","unstructured":"Suzuki A, Andrade RJ, Bjornsson E, Lucena MI, Lee WM, Yuen NA, Hunt CM, Freston JW (2010) Unified list of drugs causing hepatotoxicity and the reporting frequency of liver events in the WHO vigibaset: international collaborative work. Drug Saf 33:503\u2013522","journal-title":"Drug Saf"},{"key":"1456_CR40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1478-3231.2007.01461.x","volume":"27","author":"CT Wai","year":"2007","unstructured":"Wai CT, Tan BH, Chan CL, Sutedja DS, Lee YM, Khor C, Lim SG (2007) Drug-induced liver injury at an Asian center: a prospective study. Liver Int 27:465\u2013474","journal-title":"Liver Int."},{"key":"1456_CR41","doi-asserted-by":"crossref","first-page":"701","DOI":"10.5694\/j.1326-5377.1989.tb139652.x","volume":"151","author":"IB Turner","year":"1989","unstructured":"Turner IB, Eckstein RP, Riley JW, Lunzer MR (1989) Prolonged hepatic cholestasis after flucloxacillin therapy. Med J Aust 151:701\u2013705","journal-title":"Med J Aust"},{"key":"1456_CR42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2796.2007.01818.x","volume":"262","author":"G Wei","year":"2007","unstructured":"Wei G, Bergquist A, Broome U, Lindgren S, Wallerstedt S, Almer S, Sangfeldt P, Danielsson A Sandberg-Gertzen H, Loof L, Prytz H, Bj\u00f6rnsson E (2007) Acute liver failure in Sweden: etiology and prognosis. J Internal Med 262:393\u2013401","journal-title":"J Internal Med"},{"key":"1456_CR43","first-page":"973","volume-title":"Schiff\u00b4s diseases of the liver","author":"HJ Zimmerman","year":"1999","unstructured":"Zimmerman HJ (1999) Drug-induced liver disease. In: Sciff ER, Sorrell MF, Maddrey WC (eds) Schiff\u00b4s diseases of the liver, 8th edn. Lippincott-Raven Publishers, Philadelphia, pp 973\u20131064","edition":"8"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1456-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-015-1456-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1456-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T20:28:40Z","timestamp":1717705720000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-015-1456-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,25]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["1456"],"URL":"https:\/\/doi.org\/10.1007\/s00204-015-1456-2","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,25]]}}}