{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:41:29Z","timestamp":1761489689460,"version":"3.37.3"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["#HHSN-2612012000151"],"award-info":[{"award-number":["#HHSN-2612012000151"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00204-015-1550-5","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T14:06:45Z","timestamp":1435068405000},"page":"1251-1260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice"],"prefix":"10.1007","volume":"90","author":[{"given":"Roumen","family":"Balansky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gancho","family":"Ganchev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marietta","family":"Iltcheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna T.","family":"Micale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"La Maestra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"D\u2019Oria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon E.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"De Flora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,24]]},"reference":[{"key":"1550_CR1","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1093\/carcin\/bgm122","volume":"28","author":"R Balansky","year":"2007","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2007) Potent carcinogenicity of cigarette smoke in mice exposed early in life. Carcinogenesis 28:2236\u20132243","journal-title":"Carcinogenesis"},{"key":"1550_CR2","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1093\/carcin\/bgp128","volume":"30","author":"R Balansky","year":"2009","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2009) Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice. Carcinogenesis 30:1398\u20131401","journal-title":"Carcinogenesis"},{"key":"1550_CR3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/ijc.24942","volume":"126","author":"R Balansky","year":"2010","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2010) Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine. Int J Cancer 126:1047\u20131054","journal-title":"Int J Cancer"},{"key":"1550_CR4","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1002\/ijc.26103","volume":"130","author":"R Balansky","year":"2012","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2012a) Differential carcinogenicity of cigarette smoke in mice exposed either transplacentally, early in life or in adulthood. Int J Cancer 130:1001\u20131010","journal-title":"Int J Cancer"},{"key":"1550_CR5","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/ijc.27486","volume":"131","author":"R Balansky","year":"2012","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2012b) Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int J Cancer 131:1991\u20131997","journal-title":"Int J Cancer"},{"key":"1550_CR6","doi-asserted-by":"publisher","first-page":"164","DOI":"10.2174\/156800912799095153","volume":"12","author":"R Balansky","year":"2012","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2012c) Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy? Curr Cancer Drug Targets 12:164\u2013169","journal-title":"Curr Cancer Drug Targets"},{"key":"1550_CR7","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1093\/carcin\/bgu154","volume":"35","author":"R Balansky","year":"2014","unstructured":"Balansky R, Izzotti A, D\u2019Agostini F et al (2014) Assay of lapatinib in murine models of cigarette smoke carcinogenesis. Carcinogenesis 35:2300\u20132307","journal-title":"Carcinogenesis"},{"key":"1550_CR8","doi-asserted-by":"publisher","first-page":"188","DOI":"10.2174\/1568009615666150216170008","volume":"15","author":"R Balansky","year":"2015","unstructured":"Balansky R, Ganchev G, Iltcheva M et al (2015) Modulation by licofelone and celecoxib of experimentally induced cancer and preneoplastic lesions in mice exposed to cigarette smoke. Curr Cancer Drug Targets 15:188\u2013195","journal-title":"Curr Cancer Drug Targets"},{"key":"1550_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-3-540-69297-3_22","volume":"181","author":"C Bosetti","year":"2009","unstructured":"Bosetti C, Gallus S, La Vecchia C (2009) Aspirin and cancer risk: a summary review to 2007. Recent Results Cancer Res 181:231\u2013251","journal-title":"Recent Results Cancer Res"},{"key":"1550_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0165-1110(94)90019-1","volume":"317","author":"A Camoirano","year":"1994","unstructured":"Camoirano A, Balansky RM, Bennicelli C (1994) Experimental databases on inhibition of the bacterial mutagenicity of 4-nitroquinoline 1-oxide and cigarette smoke. Mutat Res 317:89\u2013109","journal-title":"Mutat Res"},{"key":"1550_CR11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S1470-2045(09)70035-X","volume":"10","author":"J Cuzick","year":"2009","unstructured":"Cuzick J, Otto F, Baron JA et al (2009) Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol 10:501\u2013507","journal-title":"Lancet Oncol"},{"key":"1550_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/10590501.2014.907459","volume":"32","author":"S De Flora","year":"2014","unstructured":"De Flora S, Izzotti A, D\u2019Agostini F et al (2014) Rationale and approaches to the prevention of smoking-related diseases: overview of recent studies on chemoprevention of smoking-induced tumors in rodent models. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 32:105\u2013120","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"1550_CR13","first-page":"6096","volume":"63","author":"RE Harris","year":"2003","unstructured":"Harris RE, Chlebowski RT, Jackson RD et al (2003) Breast cancer and non-steroidal anti-inflammatory drugs: prospective research from the Women\u2019s Health Initiative. Cancer Res 63:6096\u20136101","journal-title":"Cancer Res"},{"key":"1550_CR14","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3390\/ph3051550","volume":"3","author":"SL Horn","year":"2010","unstructured":"Horn SL, Fentiman IS (2010) The role of non-steroidal anti-inflammatory drugs in the chemoprevention of breast cancer. Pharmaceuticals 3:1550\u20131560","journal-title":"Pharmaceuticals"},{"key":"1550_CR15","volume-title":"A review of human carcinogens: personal habits and indoor combustions. IARC monographs on the evaluation of the carcinogenic risks to humans, vol 100, part E","author":"International Agency for Research on Cancer","year":"2012","unstructured":"International Agency for Research on Cancer (2012) A review of human carcinogens: personal habits and indoor combustions. IARC monographs on the evaluation of the carcinogenic risks to humans, vol 100, part E. IARC, Lyon"},{"key":"1550_CR16","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.mrrev.2003.05.004","volume":"544","author":"A Izzotti","year":"2003","unstructured":"Izzotti A, Balansky RM, Camoirano A, Cartiglia C, Longobardi M, Tampa E, De Flora S (2003) Birth-related genomic and transcriptional changes in mouse lung. Modulation by transplacental N-acetylcysteine. Mutat Res 544:441\u2013449","journal-title":"Mutat Res"},{"key":"1550_CR17","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1093\/carcin\/bgt178","volume":"34","author":"A Izzotti","year":"2013","unstructured":"Izzotti A, Balansky R, D\u2019Agostini F et al (2013) Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents. Carcinogenesis 34:2322\u20132329","journal-title":"Carcinogenesis"},{"key":"1550_CR18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/cam4.234","volume":"3","author":"A Izzotti","year":"2014","unstructured":"Izzotti A, Balansky R, D\u2019Agostini F et al (2014) Modulation by metformin of molecular and histopathological alterations in the lung of cigarette smoke-exposed mice. Cancer Med 3:719\u2013730","journal-title":"Cancer Med"},{"key":"1550_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0304-3835(92)90275-Z","volume":"66","author":"G Jalbert","year":"1992","unstructured":"Jalbert G, Castonguay A (1992) A effects of NSAIDs on NNK-induced pulmonary and gastric tumorigenesis in A\/J mice. Cancer Lett 66:21\u201328","journal-title":"Cancer Lett"},{"key":"1550_CR20","first-page":"74","volume":"Suppl 20","author":"GJ Kelloff","year":"1994","unstructured":"Kelloff GJ, Crowell JA, Boone CW et al (1994) Clinical development plan: aspirin. J Cell Biochem Suppl 20:74\u201385","journal-title":"J Cell Biochem"},{"key":"1550_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1054\/bjoc.1999.0904","volume":"82","author":"M Kreuzer","year":"2000","unstructured":"Kreuzer M, Boffetta P, Whitley E et al (2000) Gender differences in lung cancer risk by smoking: a multicentre case-control study in Germany and Italy. Br J Cancer 82:227\u2013233","journal-title":"Br J Cancer"},{"key":"1550_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.bcmd.2011.10.006","volume":"48","author":"A Kumar","year":"2012","unstructured":"Kumar A, Vishvakarma NK, Bharti AC et al (2012) Gender-specific antitumor action of aspirin in a murine model of a T-cell lymphoma bearing host. Blood Cells Mol Dis 48:137\u2013144","journal-title":"Blood Cells Mol Dis"},{"key":"1550_CR23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/carcin\/bgs314","volume":"34","author":"S La Maestra","year":"2013","unstructured":"La Maestra S, Micale RT, De Flora S et al (2013) DNA damage in exfoliated cells and histopathological alterations in the urinary tract of mice exposed to cigarette smoke and treated with chemopreventive agents. Carcinogenesis 34:183\u2013189","journal-title":"Carcinogenesis"},{"key":"1550_CR24","doi-asserted-by":"publisher","first-page":"28337","DOI":"10.1074\/jbc.M504178200","volume":"280","author":"SH Lee","year":"2005","unstructured":"Lee SH, Williams MV, Dubois RN et al (2005) Cyclooxygenase-2-mediated DNA damage. J Biol Chem 280:28337\u201328346","journal-title":"J Biol Chem"},{"key":"1550_CR25","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.juro.2009.12.001","volume":"183","author":"RA Lubet","year":"2010","unstructured":"Lubet RA, Steele VE, Juliana MM et al (2010) Screening agents for preventive efficacy in a bladder cancer model: study design, end points, and gefitinib and naproxen efficacy. J Urol 183:1598\u20131603","journal-title":"J Urol"},{"key":"1550_CR26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1365-2184.2006.00377.x","volume":"39","author":"JG Mahdi","year":"2006","unstructured":"Mahdi JG, Mahdi AJ, Bowen ID (2006) The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential. Cell Prolif 39:147\u2013155","journal-title":"Cell Prolif"},{"issue":"5 Suppl","key":"1550_CR27","doi-asserted-by":"publisher","first-page":"154S","DOI":"10.1378\/chest.125.5_suppl.154S-a","volume":"125","author":"AM Malkinson","year":"2004","unstructured":"Malkinson AM (2004) Evidence that inflammation encourages pulmonary adenocarcinoma formation in mice: clinical implications. Chest 125(5 Suppl):154S\u2013155S","journal-title":"Chest"},{"key":"1550_CR28","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1093\/toxsci\/kfh203","volume":"81","author":"JL Mauderly","year":"2004","unstructured":"Mauderly JL, Gigliotti AP, Barr EB et al (2004) Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. Toxicol Sci 81:280\u2013292","journal-title":"Toxicol Sci"},{"key":"1550_CR29","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/qjmed\/hci119","volume":"98","author":"D Mazhar","year":"2005","unstructured":"Mazhar D, Gillmore R, Waxman J (2005) COX and cancer. QJM 98:711\u2013718","journal-title":"QJM"},{"key":"1550_CR30","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s10552-011-9847-z","volume":"22","author":"VA McCormack","year":"2011","unstructured":"McCormack VA, Hung RJ, Brenner DR et al (2011) Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). Cancer Causes Control 22:1709\u20131720","journal-title":"Cancer Causes Control"},{"key":"1550_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1158\/1940-6207.CAPR-09-0151","volume":"3","author":"DL McCormick","year":"2010","unstructured":"McCormick DL, Phillips JM, Horn TL et al (2010) Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. Cancer Prev Res 3:73\u201381","journal-title":"Cancer Prev Res"},{"key":"1550_CR32","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1158\/1940-6207.CAPR-09-0162","volume":"3","author":"SI Meireles","year":"2010","unstructured":"Meireles SI, Esteves GH, Hirata R Jr et al (2010) Early changes in gene expression induced by tobacco smoke: evidence for the importance of estrogen within lung tissue. Cancer Prev Res 3:707\u2013717","journal-title":"Cancer Prev Res"},{"key":"1550_CR33","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/ijc.21891","volume":"119","author":"S Mollerup","year":"2006","unstructured":"Mollerup S, Berge G, Baera R et al (2006) Sex differences in risk of lung cancer: expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. Int J Cancer 119:741\u2013744","journal-title":"Int J Cancer"},{"key":"1550_CR34","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/annonc\/mdq779","volume":"22","author":"SW Oh","year":"2011","unstructured":"Oh SW, Myung SK, Park JY et al (2011) Korean Meta-analysis (KORMA) Study Group. Aspirin use and risk for lung cancer: a meta-analysis. Ann Oncol 22:2456\u20132465","journal-title":"Ann Oncol"},{"key":"1550_CR35","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/carcin\/bgs402","volume":"34","author":"J Peng","year":"2013","unstructured":"Peng J, Xu X, Mace BE et al (2013) Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis 34:909\u2013915","journal-title":"Carcinogenesis"},{"key":"1550_CR36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","volume":"377","author":"PM Rothwell","year":"2011","unstructured":"Rothwell PM, Fowkes FG, Belch JF et al (2011) Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 377:31\u201341","journal-title":"Lancet"},{"key":"1550_CR37","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3727\/096504009789745520","volume":"17","author":"RK Saini","year":"2009","unstructured":"Saini RK, Sanyal SN (2009) Chemopreventive effect of nonsteroidal anti-inflammatory drugs on 9,10-dimethylbenz[a]anthracene-induced lung carcinogenesis in mice. Oncol Res 17:505\u2013518","journal-title":"Oncol Res"},{"key":"1550_CR38","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1080\/08958370600742821","volume":"18","author":"CJ Smith","year":"2006","unstructured":"Smith CJ, Perfetti TA, King JA (2006) Perspectives on pulmonary inflammation and lung cancer risk in cigarette smokers. Inhal Toxicol 18:667\u2013677","journal-title":"Inhal Toxicol"},{"key":"1550_CR39","first-page":"37","volume":"6","author":"LP Stabile","year":"2003","unstructured":"Stabile LP, Siegfried JM (2003) Sex and gender differences in lung cancer. J Gend Specif Med 6:37\u201348","journal-title":"J Gend Specif Med"},{"key":"1550_CR40","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11912-004-0033-2","volume":"6","author":"LP Stabile","year":"2004","unstructured":"Stabile LP, Siegfried JM (2004) Estrogen receptor pathways in lung cancer. Curr Oncol Rep 6:259\u2013267","journal-title":"Curr Oncol Rep"},{"key":"1550_CR41","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1158\/1940-6207.CAPR-09-0080","volume":"2","author":"VE Steele","year":"2009","unstructured":"Steele VE, Rao CV, Zhang Y et al (2009) Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers. Cancer Prev Res 2:951\u2013956","journal-title":"Cancer Prev Res"},{"key":"1550_CR42","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1158\/1940-6207.CAPR-11-0222","volume":"4","author":"N Suh","year":"2011","unstructured":"Suh N, Reddy BS, DeCastro A et al (2011) Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65\/\u03b2-catenin\/cyclin D1 signaling pathway in rats. Cancer Prev Res 4:1895\u20131902","journal-title":"Cancer Prev Res"},{"key":"1550_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ccr.2009.12.008","volume":"17","author":"H Takahashi","year":"2010","unstructured":"Takahashi H, Ogata H, Nishigaki R et al (2010) Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell 17:89\u201397","journal-title":"Cancer Cell"},{"key":"1550_CR44","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1001\/jama.291.20.2433","volume":"291","author":"MB Terry","year":"2004","unstructured":"Terry MB, Gammon MD, Zhang FF et al (2004) Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA 291:2433\u20132440","journal-title":"JAMA"},{"key":"1550_CR45","doi-asserted-by":"publisher","first-page":"e90286","DOI":"10.1371\/journal.pone.0090286","volume":"9","author":"M Xie","year":"2014","unstructured":"Xie M, Shan Z, Zhang Y et al (2014) Aspirin for primary prevention of cardiovascular events: meta-analysis of randomized controlled trials and subgroup analysis by sex and diabetes status. PLoS ONE 9:e90286","journal-title":"PLoS ONE"},{"key":"1550_CR46","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cllc.2011.06.009","volume":"13","author":"J Xu","year":"2012","unstructured":"Xu J, Yin Z, Gao W et al (2012) Meta-analysis on the association between nonsteroidal anti-inflammatory drug use and lung cancer risk. Clin Lung Cancer 13:44\u201351","journal-title":"Clin Lung Cancer"},{"key":"1550_CR47","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0960-0760(03)00377-7","volume":"86","author":"W Yue","year":"2003","unstructured":"Yue W, Santen RJ, Wang JP et al (2003) Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J Steroid Biochem Mol Biol 86:477\u2013486","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1550_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/jnci\/88.3-4.183","volume":"88","author":"EA Zang","year":"1996","unstructured":"Zang EA, Wynder EL (1996) Differences in lung cancer risk between men and women: examination of the evidence. J Natl Cancer Inst 88:183\u2013192","journal-title":"J Natl Cancer Inst"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1550-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-015-1550-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1550-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-015-1550-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T17:29:42Z","timestamp":1717954182000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-015-1550-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,24]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1550"],"URL":"https:\/\/doi.org\/10.1007\/s00204-015-1550-5","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"type":"print","value":"0340-5761"},{"type":"electronic","value":"1432-0738"}],"subject":[],"published":{"date-parts":[[2015,6,24]]},"assertion":[{"value":"21 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}