{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:26:21Z","timestamp":1780489581678,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Japan Ministry of Education, Culture, Sports, Science, and Technology","award":["24590752"],"award-info":[{"award-number":["24590752"]}]},{"name":"The Uehara Memorial Foundation in 2009"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s00204-016-1699-6","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T14:48:43Z","timestamp":1460126923000},"page":"1949-1958","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Subchronic inhalation exposure to 2-ethyl-1-hexanol impairs the mouse olfactory bulb via injury and subsequent repair of the nasal olfactory epithelium"],"prefix":"10.1007","volume":"90","author":[{"given":"Mio","family":"Miyake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Sawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kamijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"issue":"4","key":"1699_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/cne.901370404","volume":"137","author":"J Altman","year":"1969","unstructured":"Altman J (1969) Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol 137(4):433\u2013457. doi: 10.1002\/cne.901370404","journal-title":"J Comp Neurol"},{"issue":"6","key":"1699_CR2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1177\/0748233710393398","volume":"27","author":"N Bansal","year":"2011","unstructured":"Bansal N, Uppal V, Pathak D (2011) Toxic effect of formaldehyde on the respiratory organs of rabbits: a light and electron microscopic study. Toxicol Ind Health 27(6):563\u2013569. doi: 10.1177\/0748233710393398","journal-title":"Toxicol Ind Health"},{"issue":"10","key":"1699_CR3","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1007\/s00204-014-1346-z","volume":"88","author":"T Br\u00fcning","year":"2014","unstructured":"Br\u00fcning T, Bartsch R, Bolt HM et al (2014) Sensory irritation as a basis for setting occupational exposure limits. Arch Toxicol 88(10):1855\u20131879. doi: 10.1007\/s00204-014-1346-z","journal-title":"Arch Toxicol"},{"issue":"5\u20136","key":"1699_CR4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1080\/01694243.2012.690656","volume":"27","author":"S Chino","year":"2013","unstructured":"Chino S, Kato S, Seo J, Kim J (2013) Measurement of 2-ethyl-1-hexanol emitted from flooring materials and adhesives. J Adhes Sci Technol 27(5\u20136):659\u2013670","journal-title":"J Adhes Sci Technol"},{"issue":"3","key":"1699_CR5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jat.737","volume":"21","author":"G Cruzan","year":"2001","unstructured":"Cruzan G, Cushman JR, Andrews LS et al (2001) Chronic toxicity\/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks. J Appl Toxicol 21(3):185\u2013198","journal-title":"J Appl Toxicol"},{"issue":"2","key":"1699_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1600-0668.2009.00638.x","volume":"20","author":"L Ernstg\u00e5rd","year":"2010","unstructured":"Ernstg\u00e5rd L, Norb\u00e4ck D, Nordquist T, Wieslander G, W\u00e5linder R, Johanson G (2010) Acute effects of exposure to 1\u00a0mg\/m(3) of vaporized 2-ethyl-1-hexanol in humans. Indoor Air 20(2):168\u2013175. doi: 10.1111\/j.1600-0668.2009.00638.x","journal-title":"Indoor Air"},{"issue":"1","key":"1699_CR7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0378-4274(94)90143-0","volume":"70","author":"CB Frederick","year":"1994","unstructured":"Frederick CB, Udinsky JR, Finch L (1994) The regional hydrolysis of ethyl acrylate to acrylic acid in the rat nasal cavity. Toxicol Lett 70(1):49\u201356","journal-title":"Toxicol Lett"},{"issue":"4","key":"1699_CR8","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s00420-005-0043-x","volume":"79","author":"F Gobba","year":"2006","unstructured":"Gobba F (2006) Olfactory toxicity: long-term effects of occupational exposures. Int Arch Occup Environ Health 79(4):322\u2013331. doi: 10.1007\/s00420-005-0043-x","journal-title":"Int Arch Occup Environ Health"},{"key":"1699_CR9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/01926230600713475","volume":"34","author":"J Harkema","year":"2006","unstructured":"Harkema J, Carey S, Wagner JG (2006) The nose revised: a brief review of the comparative structure function, and toxicologic pathology of the nasal epithelium. Toxicol Pathol 34:252\u2013269","journal-title":"Toxicol Pathol"},{"key":"1699_CR10","doi-asserted-by":"crossref","unstructured":"Haschek W, Rousseaux C, Wallig M (2010) Fundamentals of toxicologic pathology, 2nd edn. Academic press, London, Burlington, MA, San Diego, CA","DOI":"10.1016\/B978-0-12-370469-6.00003-9"},{"issue":"1\u20132","key":"1699_CR11","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.brainres.2003.12.052","volume":"1007","author":"H Hayashi","year":"2004","unstructured":"Hayashi H, Kunugita N, Arashidani K, Fujimaki H, Ichikawa M (2004) Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb. Brain Res 1007(1\u20132):192\u2013197. doi: 10.1016\/j.brainres.2003.12.052","journal-title":"Brain Res"},{"issue":"1","key":"1699_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.toxlet.2006.01.018","volume":"165","author":"L Jacquot","year":"2006","unstructured":"Jacquot L, Pourie G, Buron G, Monnin J, Brand G (2006) Effects of toluene inhalation exposure on olfactory functioning: behavioral and histological assessment. Toxicol Lett 165(1):57\u201365. doi: 10.1016\/j.toxlet.2006.01.018","journal-title":"Toxicol Lett"},{"key":"1699_CR13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1539\/joh.44.186","volume":"44","author":"M Kamijima","year":"2002","unstructured":"Kamijima M, Sakai K, Shibata E et al (2002) 2-Ethyl-1-hexanol in indoor air as a possible cause of sick building symptoms. J Occup Health 44:186\u2013191","journal-title":"J Occup Health"},{"issue":"12","key":"1699_CR14","first-page":"1021","volume":"52","author":"M Kamijima","year":"2005","unstructured":"Kamijima M, Shibata E, Sakai K et al (2005) Indoor air pollution due to 2-ethyl-1-hexanol airborne concentrations, emission sources and subjective symptoms in classroom users. Jpn J Public Health 52(12):1021\u20131031","journal-title":"Jpn J Public Health"},{"issue":"2","key":"1699_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neuron.2010.06.018","volume":"67","author":"N Kaneko","year":"2010","unstructured":"Kaneko N, Marin O, Koike M et al (2010) New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron 67(2):213\u2013223. doi: 10.1016\/j.neuron.2010.06.018","journal-title":"Neuron"},{"issue":"3","key":"1699_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.etap.2004.12.056","volume":"19","author":"E Kiesswetter","year":"2005","unstructured":"Kiesswetter E, Thriel C, Sch\u00e4per M, Blaszkewicz M, Seeber A (2005) Eye blinks as indicator for sensory irritation during constant and peak exposures to 2-ethylhexanol. Environ Toxicol Pharmacol 19(3):531\u2013541. doi: 10.1016\/j.etap.2004.12.056","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"1699_CR17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.tox.2004.09.008","volume":"207","author":"PJ Lapinskas","year":"2005","unstructured":"Lapinskas PJ, Brown S, Leesnitzer LM, Blanchard S, Swanson C, Cattley RC, Corton JC (2005) Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver. Toxicology 207(1):149\u2013163","journal-title":"Toxicology"},{"issue":"5162","key":"1699_CR18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.8178174","volume":"264","author":"C Lois","year":"1994","unstructured":"Lois C, Alvarez-Buylla A (1994) Long-distance neuronal migration in the adult mammalian brain. Science 264(5162):1145\u20131148","journal-title":"Science"},{"issue":"1","key":"1699_CR19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0896-6273(93)90281-U","volume":"11","author":"MB Luskin","year":"1993","unstructured":"Luskin MB (1993) Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11(1):173\u2013189","journal-title":"Neuron"},{"key":"1699_CR20","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1097\/00005537-200312000-00020","volume":"113","author":"YG Min","year":"2003","unstructured":"Min YG, Kim JW, Hong SC, Dhong HJ, Jarin PR, Jin Y (2003) Pathogenetic mechanism of olfactory cell injury after exposure to sulfur dioxide in mice. Laryngoscope 113:2157\u20132162","journal-title":"Laryngoscope"},{"key":"1699_CR21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2307\/3430684","volume":"85","author":"KT Morgan","year":"1990","unstructured":"Morgan KT, Monticello TM (1990) Airflow, gas deposition, and lesion distribution in the nasal passages. Environ Health Perspect 85:209\u2013218","journal-title":"Environ Health Perspect"},{"issue":"11","key":"1699_CR22","first-page":"1016","volume":"4","author":"D Norback","year":"2000","unstructured":"Norback D, Wieslander G, Nordstrom K, Walinder R (2000) Asthma symptoms in relation to measured building dampness in upper concrete floor construction, and 2-ethyl-1-hexanol in indoor air. Int J Tuberc Lung Dis 4(11):1016\u20131025","journal-title":"Int J Tuberc Lung Dis"},{"key":"1699_CR23","first-page":"1","volume":"371","author":"NTP","year":"1990","unstructured":"NTP (1990) National toxicology program toxicology and carcinogenesis studies of toluene (CAS No.108-88-3) in F344\/N Rats and B6C3F1 Mice (Inhalation Studies). Natl Toxicol Program Techn Rep Ser 371:1\u2013253","journal-title":"Natl Toxicol Program Techn Rep Ser"},{"issue":"1","key":"1699_CR24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000233942","volume":"79","author":"R Patterson","year":"1986","unstructured":"Patterson R, Pateras V, Grammer LC, Harris KE (1986) Human antibodies against formaldehyde-human serum albumin conjugates or human serum albumin in individuals exposed to formaldehyde. Int Arch Allergy Appl Immunol 79(1):53\u201359","journal-title":"Int Arch Allergy Appl Immunol"},{"issue":"4","key":"1699_CR25","first-page":"225","volume":"27","author":"PH Peng","year":"1992","unstructured":"Peng PH (1992) Degeneration and regeneration of olfacory epithelial neurons after olfactory nerve sectioning. Zhonghua Er Bi Yan Hou Ke Za Zhi 27(4):225\u2013227 (in Chinese)","journal-title":"Zhonghua Er Bi Yan Hou Ke Za Zhi"},{"issue":"4","key":"1699_CR26","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3200\/AEOH.59.4.194-201","volume":"59","author":"T Putus","year":"2004","unstructured":"Putus T, Tuomainen A, Rautiala S (2004) Chemical and microbial exposures in a school building: adverse health effects in children. Arch Environ Health 59(4):194\u2013201. doi: 10.3200\/AEOH.59.4.194-201","journal-title":"Arch Environ Health"},{"issue":"11","key":"1699_CR27","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1039\/b610981k","volume":"8","author":"K Sakai","year":"2006","unstructured":"Sakai K, Kamijima M, Shibata E, Ohno H, Nakajima T (2006) Indoor air pollution by 2-ethyl-1-hexanol in non-domestic buildings in Nagoya, Japan. J Environ Monit 8(11):1122\u20131128. doi: 10.1039\/b610981k","journal-title":"J Environ Monit"},{"issue":"11","key":"1699_CR28","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1039\/b910558a","volume":"11","author":"K Sakai","year":"2009","unstructured":"Sakai K, Kamijima M, Shibata E, Ohno H, Nakajima T (2009) Annual transition and seasonal variation of indoor air pollution levels of 2-ethyl-1-hexanol in large-scale buildings in Nagoya, Japan. J Environ Monit 11(11):2068\u20132076. doi: 10.1039\/b910558a","journal-title":"J Environ Monit"},{"issue":"Suppl","key":"1699_CR29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1539\/sangyoeisei.KJ00004429673","volume":"48","author":"F Sato","year":"2006","unstructured":"Sato F, Ishidao T, Kunugida N et al (2006) The effect of 2-ethyl-hexanol inhalation on morphological examination in mice. Sangyo Eiseigaku Zasshi 48(Suppl):542","journal-title":"Sangyo Eiseigaku Zasshi"},{"issue":"32","key":"1699_CR30","doi-asserted-by":"publisher","first-page":"11587","DOI":"10.1523\/JNEUROSCI.0614-11.2011","volume":"31","author":"M Sawada","year":"2011","unstructured":"Sawada M, Kaneko N, Inada H et al (2011) Sensory input regulates spatial and subtype-specific patterns of neuronal turnover in the adult olfactory bulb. J Neurosci 31(32):11587\u201311596. doi: 10.1523\/JNEUROSCI.0614-11.2011","journal-title":"J Neurosci"},{"issue":"5761","key":"1699_CR31","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1126\/science.1119133","volume":"311","author":"K Sawamoto","year":"2006","unstructured":"Sawamoto K, Wichterle H, Gonzalez-Perez O et al (2006) New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311(5761):629\u2013632. doi: 10.1126\/science.1119133","journal-title":"Science"},{"issue":"11","key":"1699_CR32","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/0002889738506887","volume":"34","author":"RA Scala","year":"1973","unstructured":"Scala RA, Burtis EG (1973) Acute toxicity of a homologous series of branched-chain primary alcohols. Am Ind Hyg Assoc J 34(11):493\u2013499. doi: 10.1080\/0002889738506887","journal-title":"Am Ind Hyg Assoc J"},{"issue":"1","key":"1699_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/cne.903590103","volume":"359","author":"JE Schwob","year":"1995","unstructured":"Schwob JE, Youngentob SL, Mezza RC (1995) Reconstitution of the rat olfactory epithelium after methyl bromide-induced lesion. J Comp Neurol 359(1):15\u201337. doi: 10.1002\/cne.903590103","journal-title":"J Comp Neurol"},{"issue":"10","key":"1699_CR34","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1093\/cercor\/bhs230","volume":"23","author":"J Seubert","year":"2013","unstructured":"Seubert J, Freiherr J, Frasnelli J, Hummel T, Lundstrom JN (2013) Orbitofrontal cortex and olfactory bulb volume predict distinct aspects of olfactory performance in healthy subjects. Cereb Cortex 23(10):2448\u20132456. doi: 10.1093\/cercor\/bhs230","journal-title":"Cereb Cortex"},{"issue":"5","key":"1699_CR35","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1080\/00028896909343157","volume":"30","author":"HF Smyth Jr","year":"1969","unstructured":"Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA, Nycum JS (1969) Range-finding toxicity data: list VII. Am Ind Hyg Assoc J 30(5):470\u2013476. doi: 10.1080\/00028896909343157","journal-title":"Am Ind Hyg Assoc J"},{"key":"1699_CR36","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.buildenv.2008.12.011","volume":"44","author":"T Tomoto","year":"2009","unstructured":"Tomoto T, Moriyoshi A, Sakai K, Shibata E, Kamijima M (2009) Identification of the sources of organic compounds that decalcify cement concrete and generate alcohols and ammonia gases. Build Environ 44:2000\u20132005","journal-title":"Build Environ"},{"issue":"2","key":"1699_CR37","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.neuro.2006.03.008","volume":"28","author":"C Thriel van","year":"2007","unstructured":"van Thriel C, Kiesswetter E, Sch\u00e4per M et al (2007) From neurotoxic to chemosensory effects: new insights on acute solvent neurotoxicity exemplified by acute effects of 2-ethylhexanol. Neurotoxicology 28(2):347\u2013355. doi: 10.1016\/j.neuro.2006.03.008","journal-title":"Neurotoxicology"},{"issue":"7","key":"1699_CR38","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s004200050398","volume":"72","author":"G Wieslander","year":"1999","unstructured":"Wieslander G, Norback D, Nordstrom K, Walinder R, Venge P (1999) Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitals. Int Arch Occup Environ Health 72(7):451\u2013461","journal-title":"Int Arch Occup Environ Health"},{"issue":"1","key":"1699_CR39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/19338240903390248","volume":"65","author":"G Wieslander","year":"2010","unstructured":"Wieslander G, Kumlin A, Norback D (2010) Dampness and 2-ethyl-1-hexanol in floor construction of rehabilitation center: health effects in staff. Arch Environ Occup Health 65(1):3\u201311. doi: 10.1080\/19338240903390248","journal-title":"Arch Environ Occup Health"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-016-1699-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-016-1699-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-016-1699-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T06:46:05Z","timestamp":1567752365000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-016-1699-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1699"],"URL":"https:\/\/doi.org\/10.1007\/s00204-016-1699-6","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]}}}