{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:51:48Z","timestamp":1772787108217,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (AR)","award":["PIP0771 and PIP 0356"],"award-info":[{"award-number":["PIP0771 and PIP 0356"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1007\/s00204-017-1936-7","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T07:28:10Z","timestamp":1491377290000},"page":"3065-3078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells"],"prefix":"10.1007","volume":"91","author":[{"given":"R. M.","family":"Gorojod","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alaimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Porte Alcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Saravia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3555-7621","authenticated-orcid":false,"given":"M. L.","family":"Kotler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"1936_CR1","unstructured":"Alaimo A (2012) Neurotoxicidad inducida por manganeso. V\u00edas de muerte apopt\u00f3ticas y rol de la din\u00e1mica mitocondrial. Universidad de Buenos Aires"},{"key":"1936_CR2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuint.2011.06.001","volume":"59","author":"A Alaimo","year":"2011","unstructured":"Alaimo A, Gorojod RM, Kotler ML (2011) The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells. Neurochem Int 59:297\u2013308","journal-title":"Neurochem Int"},{"key":"1936_CR3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neulet.2013.08.061","volume":"554","author":"A Alaimo","year":"2013","unstructured":"Alaimo A, Gorojod RM, Miglietta EA, Villarreal A, Ramos AJ, Kotler ML (2013) Manganese induces mitochondrial dynamics impairment and apoptotic cell death: a study in human Gli36 cells. Neurosci Lett 554:76\u201381","journal-title":"Neurosci Lett"},{"key":"1936_CR4","doi-asserted-by":"crossref","first-page":"e91848","DOI":"10.1371\/journal.pone.0091848","volume":"9","author":"A Alaimo","year":"2014","unstructured":"Alaimo A, Gorojod RM, Beauquis J, Mu\u00f1oz MJ, Saravia F, Kotler ML (2014) Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis. PLoS One 9:e91848","journal-title":"PLoS One"},{"key":"1936_CR5","first-page":"231","volume":"42","author":"H Appelqvist","year":"2012","unstructured":"Appelqvist H, Johansson AC, Linderoth E, Johansson U, Antonsson B, Steinfeld R, K\u00e5gedal K, Ollinger K (2012) Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183. Ann Clin Lab Sci 42:231\u2013242","journal-title":"Ann Clin Lab Sci"},{"key":"1936_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2165\/00139709-200625030-00002","volume":"25","author":"M Aschner","year":"2006","unstructured":"Aschner M, Dorman DC (2006) Manganese: pharmacokinetics and molecular mechanisms of brain uptake. Toxicol Rev 25:147\u2013154","journal-title":"Toxicol Rev"},{"key":"1936_CR7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuroscience.2014.10.003","volume":"284","author":"M Banerjee","year":"2015","unstructured":"Banerjee M, Sasse VA, Wang Y, Maulik M, Kar S (2015) Increased levels and activity of cathepsins B and D in kainate-induced toxicity. Neuroscience 284:360\u2013373","journal-title":"Neuroscience"},{"key":"1936_CR8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.161.3839.370","volume":"161","author":"P Benda","year":"1968","unstructured":"Benda P, Lightbody J, Sato G, Levine L, Sweet W (1968) Differentiated rat glial cell strain in tissue culture. Science 161:370\u2013371","journal-title":"Science"},{"key":"1936_CR9","doi-asserted-by":"crossref","first-page":"31401","DOI":"10.1074\/jbc.M301911200","volume":"278","author":"N Bid\u00e8re","year":"2003","unstructured":"Bid\u00e8re N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C, Senik A (2003) Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278:31401\u201331411","journal-title":"J Biol Chem"},{"key":"1936_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jtemb.2011.08.144","volume":"25","author":"AB Bowman","year":"2011","unstructured":"Bowman AB, Kwakye GF, Herrero Hern\u00e1ndez E, Aschner M (2011) Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol 25:191\u2013203","journal-title":"J Trace Elem Med Biol"},{"key":"1936_CR11","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/onc.2008.310","volume":"27","author":"P Boya","year":"2008","unstructured":"Boya P, Kroemer G (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27:6434\u20136451","journal-title":"Oncogene"},{"key":"1936_CR12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1936_CR13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0896-6273(95)90324-0","volume":"14","author":"AM Cataldo","year":"1995","unstructured":"Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA (1995) Gene expression and cellular content of cathepsin D in Alzheimer\u2019s disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14:671\u2013680","journal-title":"Neuron"},{"key":"1936_CR14","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1074\/jbc.M308347200","volume":"279","author":"T Cirman","year":"2004","unstructured":"Cirman T, Oresi\u0107 K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B (2004) Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem 279:3578\u20133587","journal-title":"J Biol Chem"},{"key":"1936_CR15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1084\/jem.20072152","volume":"205","author":"S Conus","year":"2008","unstructured":"Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU (2008) Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation. J Exp Med 205:685\u2013698","journal-title":"J Exp Med"},{"key":"1936_CR16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.scitotenv.2004.04.044","volume":"334\u2013335","author":"KM Erikson","year":"2004","unstructured":"Erikson KM, Dobson AW, Dorman DC, Aschner M (2004) Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ 334\u2013335:409\u2013416","journal-title":"Sci Total Environ"},{"key":"1936_CR17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuint.2009.11.001","volume":"56","author":"X Fan","year":"2010","unstructured":"Fan X, Luo G, Yang D, Ming M, Liu H, Pu P, Le W (2010) Critical role of lysosome and its associated protein cathepsin D in manganese-induced toxicity in cultured midbrain astrocyte. Neurochem Int 56:291\u2013300","journal-title":"Neurochem Int"},{"key":"1936_CR18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1039\/c4mt00022f","volume":"6","author":"K Fernsebner","year":"2014","unstructured":"Fernsebner K, Zorn J, Kanawati B, Walker A, Michalke B (2014) Manganese leads to an increase in markers of oxidative stress as well as to a shift in the ratio of Fe(II)\/(III) in rat brain tissue. Met Integr Biometal Sci 6:921\u2013931","journal-title":"Met Integr Biometal Sci"},{"key":"1936_CR19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","volume":"126","author":"C Frezza","year":"2006","unstructured":"Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko GV, Rudka T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L (2006) OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126:177\u2013189","journal-title":"Cell"},{"key":"1936_CR20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuint.2008.09.008","volume":"53","author":"LE Gonzalez","year":"2008","unstructured":"Gonzalez LE, Juknat AA, Venosa AJ, Verrengia N, Kotler ML (2008) Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family. Neurochem Int 53:408\u2013415","journal-title":"Neurochem Int"},{"key":"1936_CR21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.freeradbiomed.2015.06.034","volume":"87","author":"RM Gorojod","year":"2015","unstructured":"Gorojod RM, Alaimo A, Porte Alcon S, Pomilio C, Saravia F, Kotler ML (2015) The autophagic-lysosomal pathway determines the fate of glial cells under manganese-induced oxidative stress conditions. Free Radic Biol Med 87:237\u2013251","journal-title":"Free Radic Biol Med"},{"key":"1936_CR22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1172\/JCI9914","volume":"106","author":"ME Guicciardi","year":"2000","unstructured":"Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH, Gores GJ (2000) Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106:1127\u20131137","journal-title":"J Clin Invest"},{"key":"1936_CR23","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.0901748","volume":"118","author":"TR Guilarte","year":"2010","unstructured":"Guilarte TR (2010) Manganese and Parkinson\u2019s disease: a critical review and new findings. Environ Health Perspect 118:1071\u20131080","journal-title":"Environ Health Perspect"},{"key":"1936_CR24","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.neuro.2006.05.002","volume":"27","author":"TE Gunter","year":"2006","unstructured":"Gunter TE, Gavin CE, Aschner M, Gunter KK (2006) Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity. Neurotoxicology 27:765\u2013776","journal-title":"Neurotoxicology"},{"key":"1936_CR25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.cdd.4401382","volume":"11","author":"M Heinrich","year":"2004","unstructured":"Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneider-Brachert W, Trauzold A, Hethke A (2004) S. Sch\u00fctze, Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and \u2013 3 activation. Cell Death Differ 11:550\u2013563","journal-title":"Cell Death Differ"},{"key":"1936_CR26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2016.01.102","volume":"470","author":"L Li","year":"2016","unstructured":"Li L, Gao L, Song Y, Qin ZH, Liang Z (2016) Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine. Biochem Biophys Res Commun 470:579\u2013585","journal-title":"Biochem Biophys Res Commun"},{"key":"1936_CR27","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1016\/j.biocel.2013.08.012","volume":"45","author":"J Marino","year":"2013","unstructured":"Marino J, Garc\u00eda Vior MC, Furmento VA, Blank VC, Awruch J, Roguin LP (2013) Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity. Int J Biochem Cell Biol 45:2553\u20132562","journal-title":"Int J Biochem Cell Biol"},{"key":"1936_CR28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00432-005-0053-9","volume":"132","author":"NS Nagaraj","year":"2006","unstructured":"Nagaraj NS, Vigneswaran N, Zacharias W (2006) Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells. J Cancer Res Clin Oncol 132:171\u2013183","journal-title":"J Cancer Res Clin Oncol"},{"key":"1936_CR29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","volume":"19","author":"RA Nixon","year":"2013","unstructured":"Nixon RA (2013) The role of autophagy in neurodegenerative disease. Nat Med 19:983\u2013997","journal-title":"Nat Med"},{"key":"1936_CR30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4161\/auto.6259","volume":"4","author":"RA Nixon","year":"2008","unstructured":"Nixon RA, Yang DS, Lee JH (2008) Neurodegenerative lysosomal disorders: a continuum from development to late age. Autophagy 4:590\u2013599","journal-title":"Autophagy"},{"key":"1936_CR31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1128\/MCB.23.2.665-676.2003","volume":"23","author":"K Ono","year":"2003","unstructured":"Ono K, Kim SO, Han J (2003) Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death. Mol Cell Biol 23:665\u2013676","journal-title":"Mol Cell Biol"},{"key":"1936_CR32","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2006","unstructured":"Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates. Academic Press, London"},{"key":"1936_CR33","doi-asserted-by":"crossref","first-page":"32333","DOI":"10.1074\/jbc.M402096200","volume":"279","author":"KVR Rao","year":"2004","unstructured":"Rao KVR, Norenberg MD (2004) Manganese induces the mitochondrial permeability transition in cultured astrocytes. J Biol Chem 279:32333\u201332338","journal-title":"J Biol Chem"},{"key":"1936_CR34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/labinvest.3780222","volume":"81","author":"K Roberg","year":"2001","unstructured":"Roberg K (2001) Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Lab Investig J Tech Methods Pathol 81:149\u2013158","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"1936_CR35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nyas.12966","volume":"1371","author":"A Serrano-Puebla","year":"2016","unstructured":"Serrano-Puebla A, Boya P (2016) Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease. Ann N Y Acad Sci 1371:30\u201344","journal-title":"Ann N Y Acad Sci"},{"key":"1936_CR36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0041-008X(83)90030-3","volume":"71","author":"H Suzuki","year":"1983","unstructured":"Suzuki H, Wada O, Inoue K, Tosaka H, Ono T (1983) Role of brain lysosomes in the development of manganese toxicity in mice. Toxicol Appl Pharmacol 71:422\u2013429","journal-title":"Toxicol Appl Pharmacol"},{"key":"1936_CR37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","volume":"11","author":"SWG Tait","year":"2010","unstructured":"Tait SWG, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621\u2013632","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1936_CR38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00971853","volume":"13","author":"G Tholey","year":"1988","unstructured":"Tholey G, Ledig M, Mandel P, Sargentini L, Frivold AH, Leroy M, Grippo AA, Wedler FC (1988) Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex. Neurochem Res 13:45\u201350","journal-title":"Neurochem Res"},{"key":"1936_CR39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4161\/auto.7.1.13933","volume":"7","author":"M Vila","year":"2011","unstructured":"Vila M, Bov\u00e9 J, Dehay B, Rodr\u00edguez-Muela N, Boya P (2011) Lysosomal membrane permeabilization in Parkinson disease. Autophagy 7:98\u2013100","journal-title":"Autophagy"},{"key":"1936_CR40","doi-asserted-by":"crossref","first-page":"G436","DOI":"10.1152\/ajpgi.00019.2004","volume":"287","author":"N Werneburg","year":"2004","unstructured":"Werneburg N, Guicciardi ME, Yin XM, Gores GJ (2004) TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8\/Bid dependent. Am J Physiol Gastrointest Liver Physiol 287:G436\u2013G443","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1936_CR41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/aja.1001660404","volume":"166","author":"JN Whitaker","year":"1983","unstructured":"Whitaker JN, Rhodes RH (1983) The distribution of cathepsin D in rat tissues determined by immunocytochemistry. Am J Anat 166:417\u2013428","journal-title":"Am J Anat"},{"key":"1936_CR42","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuro.2009.07.011","volume":"30","author":"B Xu","year":"2009","unstructured":"Xu B, Xu ZF, Deng Y (2009) Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology 30:941\u2013949","journal-title":"Neurotoxicology"},{"key":"1936_CR43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1750-1326-6-52","volume":"6","author":"SV Yelamanchili","year":"2011","unstructured":"Yelamanchili SV, Chaudhuri AD, Flynn CT, Fox HS (2011) Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism. Mol Neurodegener 6:52","journal-title":"Mol Neurodegener"},{"key":"1936_CR44","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/abbs\/gmp031","volume":"41","author":"L Zhang","year":"2009","unstructured":"Zhang L, Sheng R, Qin Z (2009) The lysosome and neurodegenerative diseases. Acta Biochim Biophys Sin 41:437\u2013445","journal-title":"Acta Biochim Biophys Sin"},{"key":"1936_CR45","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1046\/j.1432-1033.2003.03765.x","volume":"270","author":"M Zhao","year":"2003","unstructured":"Zhao M, Antunes F, Eaton JW, Brunk UT (2003) Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur J Biochem FEBS 270:3778\u20133786","journal-title":"Eur J Biochem FEBS"},{"key":"1936_CR46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/toxsci\/kfn213","volume":"107","author":"F Zhao","year":"2009","unstructured":"Zhao F, Cai T, Liu M, Zheng G, Luo W, Chen J (2009) Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol Sci 107:156\u2013164","journal-title":"Toxicol Sci"},{"key":"1936_CR47","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1194\/jlr.M027557","volume":"53","author":"K Zhao","year":"2012","unstructured":"Zhao K, Zhou H, Zhao X, Wolff DW, Tu Y, Liu H, Wei T, Yang F (2012) Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis. J Lipid Res 53:2102\u20132114","journal-title":"J Lipid Res"},{"key":"1936_CR48","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/01.WCB.0000056062.25434.4D","volume":"23","author":"C Zwingmann","year":"2003","unstructured":"Zwingmann C, Leibfritz D, Hazell AS (2003) Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis. J Cereb Blood Flow Metab 23:756\u2013771","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-017-1936-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-1936-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-1936-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T02:20:31Z","timestamp":1506306031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-017-1936-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["1936"],"URL":"https:\/\/doi.org\/10.1007\/s00204-017-1936-7","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}