{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:12:57Z","timestamp":1789708377265,"version":"4.0.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["107361"],"award-info":[{"award-number":["107361"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Forschungskommission of the Medical Faculty of the Heinrich Heine University Duesseldorf","award":["49\/2011"],"award-info":[{"award-number":["49\/2011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00204-017-2017-7","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T12:49:32Z","timestamp":1500036572000},"page":"441-453","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rac1-mediated cardiac damage causes diastolic dysfunction in a mouse model of subacute doxorubicin-induced cardiotoxicity"],"prefix":"10.1007","volume":"92","author":[{"given":"Jan","family":"Ohlig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Henninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Zander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Merx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"issue":"9","key":"2017_CR1","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.jacc.2011.05.025","volume":"58","author":"Z Acar","year":"2011","unstructured":"Acar Z, Kale A, Turgut M et al (2011) Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy. J Am Coll Cardiol 58(9):988\u2013989. doi: 10.1016\/j.jacc.2011.05.025","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2017_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S0195-668X(02)00419-0","volume":"24","author":"PO Bonetti","year":"2003","unstructured":"Bonetti PO, Lerman LO, Napoli C, Lerman A (2003) Statin effects beyond lipid lowering\u2014Are they clinically relevant? Eur Heart J 24(3):225\u2013248. doi: 10.1016\/S0195-668X(02)00419-0","journal-title":"Eur Heart J"},{"key":"2017_CR3","doi-asserted-by":"publisher","first-page":"e558","DOI":"10.1038\/cddis.2013.57","volume":"4","author":"A Bopp","year":"2013","unstructured":"Bopp A, Wartlick F, Henninger C, Kaina B, Fritz G (2013) Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging. Cell Death Dis 4:e558. doi: 10.1038\/cddis.2013.57","journal-title":"Cell Death Dis"},{"issue":"3","key":"2017_CR4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jacc.2009.03.095","volume":"55","author":"D Cardinale","year":"2010","unstructured":"Cardinale D, Colombo A, Lamantia G et al (2010) Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55(3):213\u2013220. doi: 10.1016\/j.jacc.2009.03.095","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"2017_CR5","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/sj.bjp.0706953","volume":"149","author":"J Damrot","year":"2006","unstructured":"Damrot J, Nubel T, Epe B, Roos WP, Kaina B, Fritz G (2006) Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide. Br J Pharmacol 149(8):988\u2013997. doi: 10.1038\/sj.bjp.0706953","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2017_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(01)00765-8","volume":"415","author":"EL Beer De","year":"2001","unstructured":"De Beer EL, Bottone AE, Voest EE (2001) Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: a review. Eur J Pharmacol 415(1):1\u201311","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"2017_CR7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s11886-012-0256-z","volume":"14","author":"JM DeCara","year":"2012","unstructured":"DeCara JM (2012) Early detection of chemotherapy-related left ventricular dysfunction. Curr Cardiol Rep 14(3):334\u2013341. doi: 10.1007\/s11886-012-0256-z","journal-title":"Curr Cardiol Rep"},{"issue":"7","key":"2017_CR8","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1038\/sj.bjp.0704173","volume":"133","author":"M Eberlein","year":"2001","unstructured":"Eberlein M, Heusinger-Ribeiro J, Goppelt-Struebe M (2001) Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br J Pharmacol 133(7):1172\u20131180. doi: 10.1038\/sj.bjp.0704173","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2017_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.2174\/187152508785909474","volume":"6","author":"AL Ferreira","year":"2008","unstructured":"Ferreira AL, Matsubara LS, Matsubara BB (2008) Anthracycline-induced cardiotoxicity. Cardiovasc Hematol Agents Med Chem 6(4):278\u2013281. doi: 10.2174\/187152508785909474","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"issue":"5","key":"2017_CR10","first-page":"1401","volume":"27","author":"G Fritz","year":"2005","unstructured":"Fritz G (2005) HMG-CoA reductase inhibitors (statins) as anticancer drugs (review). Int J Oncol 27(5):1401\u20131409","journal-title":"Int J Oncol"},{"issue":"20","key":"2017_CR11","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.1073\/pnas.0307512101","volume":"101","author":"Y Gao","year":"2004","unstructured":"Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y (2004) Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 101(20):7618\u20137623. doi: 10.1073\/pnas.0307512101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2017_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12012-011-9149-4","volume":"12","author":"O Garrone","year":"2012","unstructured":"Garrone O, Crosetto N, Lo Nigro C et al (2012) Prediction of anthracycline cardiotoxicity after chemotherapy by biomarkers kinetic analysis. Cardiovasc Toxicol 12(2):135\u2013142. doi: 10.1007\/s12012-011-9149-4","journal-title":"Cardiovasc Toxicol"},{"issue":"7","key":"2017_CR13","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/s0006-2952(98)00307-4","volume":"57","author":"DA Gewirtz","year":"1999","unstructured":"Gewirtz DA (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol 57(7):727\u2013741. doi: 10.1016\/s0006-2952(98)00307-4","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"2017_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1006\/excr.2001.5165","volume":"264","author":"R Gnad","year":"2001","unstructured":"Gnad R, Kaina B, Fritz G (2001) Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress. Exp Cell Res 264(2):244\u2013249. doi: 10.1006\/excr.2001.5165","journal-title":"Exp Cell Res"},{"issue":"5","key":"2017_CR15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/SHK.0b013e31824caa96","volume":"37","author":"F Guo","year":"2012","unstructured":"Guo F, Xing Y, Zhou Z et al (2012) Guanine-nucleotide exchange factor H1 mediates lipopolysaccharide-induced interleukin 6 and tumor necrosis factor alpha expression in endothelial cells via activation of nuclear factor kappaB. Shock 37(5):531\u2013538. doi: 10.1097\/SHK.0b013e31824caa96","journal-title":"Shock"},{"issue":"5","key":"2017_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1091\/mbc.3.5.475","volume":"3","author":"A Hall","year":"1992","unstructured":"Hall A (1992) Ras-related GTPases and the cytoskeleton. Mol Biol Cell 3(5):475\u2013479. doi: 10.1091\/mbc.3.5.475","journal-title":"Mol Biol Cell"},{"issue":"1","key":"2017_CR17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.taap.2012.03.012","volume":"261","author":"C Henninger","year":"2012","unstructured":"Henninger C, Huelsenbeck J, Huelsenbeck S et al (2012) The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. Toxicol Appl Pharmacol 261(1):66\u201373. doi: 10.1016\/j.taap.2012.03.012","journal-title":"Toxicol Appl Pharmacol"},{"key":"2017_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.phrs.2014.11.003","volume":"91","author":"C Henninger","year":"2015","unstructured":"Henninger C, Huelsenbeck S, Wenzel P et al (2015) Chronic heart damage following doxorubicin treatment is alleviated by lovastatin. Pharmacol Res 91:47\u201356. doi: 10.1016\/j.phrs.2014.11.003","journal-title":"Pharmacol Res"},{"issue":"4","key":"2017_CR19","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1161\/01.RES.0000204727.46710.5e","volume":"98","author":"PL Hordijk","year":"2006","unstructured":"Hordijk PL (2006) Regulation of NADPH oxidases: the role of Rac proteins. Circ Res 98(4):453\u2013462. doi: 10.1161\/01.RES.0000204727.46710.5e","journal-title":"Circ Res"},{"key":"2017_CR20","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1038\/cddis.2011.65","volume":"2","author":"J Huelsenbeck","year":"2011","unstructured":"Huelsenbeck J, Henninger C, Schad A, Lackner KJ, Kaina B, Fritz G (2011) Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis 2:e190. doi: 10.1038\/cddis.2011.65","journal-title":"Cell Death Dis"},{"issue":"46","key":"2017_CR21","doi-asserted-by":"publisher","first-page":"38590","DOI":"10.1074\/jbc.M112.377903","volume":"287","author":"SC Huelsenbeck","year":"2012","unstructured":"Huelsenbeck SC, Schorr A, Roos WP et al (2012) Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons. J Biol Chem 287(46):38590\u201338599. doi: 10.1074\/jbc.M112.377903","journal-title":"J Biol Chem"},{"issue":"1","key":"2017_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.pharmthera.2009.01.002","volume":"122","author":"A Ludman","year":"2009","unstructured":"Ludman A, Venugopal V, Yellon DM, Hausenloy DJ (2009) Statins and cardioprotection-more than just lipid lowering? Pharmacol Ther 122(1):30\u201343. doi: 10.1016\/j.pharmthera.2009.01.002","journal-title":"Pharmacol Ther"},{"issue":"18","key":"2017_CR23","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-07-1649","volume":"67","author":"YL Lyu","year":"2007","unstructured":"Lyu YL, Kerrigan JE, Lin CP et al (2007) Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res 67(18):8839\u20138846. doi: 10.1158\/0008-5472.CAN-07-1649","journal-title":"Cancer Res"},{"issue":"1","key":"2017_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/cvr\/cvs309","volume":"97","author":"J Ma","year":"2013","unstructured":"Ma J, Wang Y, Zheng D, Wei M, Xu H, Peng T (2013) Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways. Cardiovasc Res 97(1):77\u201387. doi: 10.1093\/cvr\/cvs309","journal-title":"Cardiovasc Res"},{"issue":"1","key":"2017_CR25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-3565(25)32375-X","volume":"216","author":"BJ Marafino Jr","year":"1981","unstructured":"Marafino BJ Jr., Giri SN, Siegel DM (1981) Pharmacokinetics, covalent binding and subcellular distribution of [3H]doxorubicin after intravenous administration in the mouse. J Pharmacol Exp Ther 216(1):55\u201361 ( http:\/\/jpet.aspetjournals.org\/content\/216\/1\/55.long )","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"2017_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/01.CIR.101.2.207","volume":"101","author":"DJ Maron","year":"2000","unstructured":"Maron DJ, Fazio S, Linton MF (2000) Current perspectives on statins. Circulation 101(2):207\u2013213. doi: 10.1161\/01.CIR.101.2.207","journal-title":"Circulation"},{"issue":"2","key":"2017_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1124\/pr.56.2.6","volume":"56","author":"G Minotti","year":"2004","unstructured":"Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56(2):185\u2013229. doi: 10.1124\/pr.56.2.6","journal-title":"Pharmacol Rev"},{"key":"2017_CR28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0091-679X(04)75014-1","volume":"75","author":"PL Olive","year":"2004","unstructured":"Olive PL (2004) Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation. Methods Cell Biol 75:355\u2013373","journal-title":"Methods Cell Biol"},{"issue":"4","key":"2017_CR29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1101\/gad.11.4.463","volume":"11","author":"R Perona","year":"1997","unstructured":"Perona R, Montaner S, Saniger L, Sanchez-Perez I, Bravo R, Lacal JC (1997) Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev 11(4):463\u2013475","journal-title":"Genes Dev"},{"issue":"2","key":"2017_CR30","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1158\/0008-5472.CAN-08-3076","volume":"69","author":"A Riad","year":"2009","unstructured":"Riad A, Bien S, Westermann D et al (2009) Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res 69(2):695\u2013699. doi: 10.1158\/0008-5472.CAN-08-3076","journal-title":"Cancer Res"},{"issue":"12","key":"2017_CR31","doi-asserted-by":"publisher","first-page":"e3959","DOI":"10.1371\/journal.pone.0003959","volume":"3","author":"J Rodriguez-Vita","year":"2008","unstructured":"Rodriguez-Vita J, Sanchez-Galan E, Santamaria B et al (2008) Essential role of TGF-beta\/Smad pathway on statin dependent vascular smooth muscle cell regulation. PLoS One 3(12):e3959. doi: 10.1371\/journal.pone.0003959","journal-title":"PLoS One"},{"issue":"3","key":"2017_CR32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/bf01954271","volume":"154","author":"K Schmitt","year":"1995","unstructured":"Schmitt K, Tulzer G, Merl M et al (1995) Early detection of doxorubicin and daunorubicin cardiotoxicity by echocardiography: diastolic versus systolic parameters. Eur J Pediatr 154(3):201\u2013204. doi: 10.1007\/bf01954271","journal-title":"Eur J Pediatr"},{"issue":"23","key":"2017_CR33","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1016\/j.jacc.2012.07.067","volume":"60","author":"S Seicean","year":"2012","unstructured":"Seicean S, Seicean A, Plana JC, Budd GT, Marwick TH (2012) Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort study. J Am Coll Cardiol 60(23):2384\u20132390. doi: 10.1016\/j.jacc.2012.07.067","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"2017_CR34","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1001\/jama.1991.03470120074036","volume":"266","author":"LJ Steinherz","year":"1991","unstructured":"Steinherz LJ, Steinherz PG, Tan CT, Heller G, Murphy ML (1991) Cardiac toxicity 4\u201320\u00a0years after completing anthracycline therapy. JAMA 266(12):1672\u20131677. doi: 10.1001\/jama.1991.03470120074036","journal-title":"JAMA"},{"issue":"3","key":"2017_CR35","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1093\/ehjci\/jes139","volume":"14","author":"PW Stoodley","year":"2013","unstructured":"Stoodley PW, Richards DA, Boyd A et al (2013) Altered left ventricular longitudinal diastolic function correlates with reduced systolic function immediately after anthracycline chemotherapy. Eur Heart J Cardiovasc Imaging 14(3):228\u2013234. doi: 10.1093\/ehjci\/jes139","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"2","key":"2017_CR36","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.euje.2005.04.009","volume":"7","author":"S Tassan-Mangina","year":"2006","unstructured":"Tassan-Mangina S, Codorean D, Metivier M et al (2006) Tissue Doppler imaging and conventional echocardiography after anthracycline treatment in adults: early and late alterations of left ventricular function during a prospective study. Eur J Echocardiogr 7(2):141\u2013146. doi: 10.1016\/j.euje.2005.04.009","journal-title":"Eur J Echocardiogr"},{"key":"2017_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fonc.2014.00277","volume":"4","author":"S Tian","year":"2014","unstructured":"Tian S, Hirshfield KM, Jabbour SK et al (2014) Serum biomarkers for the detection of cardiac toxicity after chemotherapy and radiation therapy in breast cancer patients. Front Oncol 4:277. doi: 10.3389\/fonc.2014.00277","journal-title":"Front Oncol"},{"issue":"12","key":"2017_CR38","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1016\/j.bbamcr.2013.08.016","volume":"1833","author":"F Wartlick","year":"2013","unstructured":"Wartlick F, Bopp A, Henninger C, Fritz G (2013) DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac. Biochim Biophys Acta 1833(12):3093\u20133103. doi: 10.1016\/j.bbamcr.2013.08.016","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2017_CR39","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0022-3565(24)39082-2","volume":"294","author":"DM Weinstein","year":"2000","unstructured":"Weinstein DM, Mihm MJ, Bauer JA (2000) Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice. J Pharmacol Exp Ther 294(1):396\u2013401 ( http:\/\/jpet.aspetjournals.org\/content\/294\/1\/396.long )","journal-title":"J Pharmacol Exp Ther"},{"issue":"5","key":"2017_CR40","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1111\/j.1365-2141.2005.05759.x","volume":"131","author":"KA Wouters","year":"2005","unstructured":"Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131(5):561\u2013578. doi: 10.1111\/j.1365-2141.2005.05759.x","journal-title":"Br J Haematol"},{"issue":"8","key":"2017_CR41","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1172\/JCI44371","volume":"121","author":"SY Xiang","year":"2011","unstructured":"Xiang SY, Vanhoutte D, Del Re DP et al (2011) RhoA protects the mouse heart against ischemia\/reperfusion injury. J Clin Invest 121(8):3269\u20133276. doi: 10.1172\/JCI44371","journal-title":"J Clin Invest"},{"issue":"5","key":"2017_CR42","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.yjmcc.2009.07.024","volume":"47","author":"M Yoshida","year":"2009","unstructured":"Yoshida M, Shiojima I, Ikeda H, Komuro I (2009) Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity. J Mol Cell Cardiol 47(5):698\u2013705. doi: 10.1016\/j.yjmcc.2009.07.024","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"2017_CR43","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1093\/oxfordjournals.eurheartj.a014753","volume":"17","author":"CM Yu","year":"1996","unstructured":"Yu CM, Sanderson JE, Shum IO et al (1996) Diastolic dysfunction and natriuretic peptides in systolic heart failure. Higher ANP and BNP levels are associated with the restrictive filling pattern. Eur Heart J 17(11):1694\u20131702. doi: 10.1093\/oxfordjournals.eurheartj.a014753","journal-title":"Eur Heart J"},{"issue":"8","key":"2017_CR44","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.echo.2010.05.017","volume":"23","author":"L Yuan","year":"2010","unstructured":"Yuan L, Wang T, Liu F, Cohen ED, Patel VV (2010) An evaluation of transmitral and pulmonary venous Doppler indices for assessing murine left ventricular diastolic function. J Am Soc Echocardiogr 23(8):887\u2013897. doi: 10.1016\/j.echo.2010.05.017","journal-title":"J Am Soc Echocardiogr"},{"issue":"5","key":"2017_CR45","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1253\/circj.CJ-10-0110","volume":"74","author":"Q Zhou","year":"2010","unstructured":"Zhou Q, Liao JK (2010) Pleiotropic effects of statins\u2014basic research and clinical perspectives. Circ J 74(5):818\u2013826","journal-title":"Circ J"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-017-2017-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2017-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2017-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T21:20:56Z","timestamp":1750627256000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-017-2017-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1007\/s00204-017-2017-7","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]}}}