{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:35:19Z","timestamp":1792791319621,"version":"4.5.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00204-017-2043-5","type":"journal-article","created":{"date-parts":[[2017,8,27]],"date-time":"2017-08-27T22:05:01Z","timestamp":1503871501000},"page":"3211-3223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":343,"title":["Toxicological interactions of pesticide mixtures: an update"],"prefix":"10.1007","volume":"91","author":[{"given":"Antonio F.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lacasa\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"2043_CR1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2012.01.010","volume":"294","author":"K Abass","year":"2012","unstructured":"Abass K, L\u00e4ms\u00e4 V, Reponen P, K\u00fcblbeck J, Honkakoski P, Mattila S, Pelkonen O, Hakkola J (2012) Characterization of human cytochrome P450 induction by pesticides. Toxicology 294:17\u201326","journal-title":"Toxicology"},{"key":"2043_CR2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0041-008X(96)80035-4","volume":"141","author":"LJ Bain","year":"1996","unstructured":"Bain LJ, LeBlanc GA (1996) Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol Appl Pharmacol 141:288\u2013298","journal-title":"Toxicol Appl Pharmacol"},{"key":"2043_CR3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/ieam.5630030307","volume":"3","author":"JB Belden","year":"2007","unstructured":"Belden JB, Gilliom RJ, Lydy MJ (2007) How well can we predict the toxicity of pesticide mixtures to aquatic life? Integr Environ Assess Manag 3:364\u2013372","journal-title":"Integr Environ Assess Manag"},{"key":"2043_CR100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","volume":"41","author":"MC Berenbaum","year":"1989","unstructured":"Berenbaum MC (1989) What is synergy? Pharmacol Rev 41:93\u2013141","journal-title":"Pharmacol Rev"},{"key":"2043_CR4","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbt.21458","volume":"27","author":"KM Bircsak","year":"2013","unstructured":"Bircsak KM, Richardson JR, Aleksunes LM (2013) Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides. J Biochem Mol Toxicol 27:157\u2013164","journal-title":"J Biochem Mol Toxicol"},{"key":"2043_CR5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquatox.2016.10.020","volume":"182","author":"MA Bjergager","year":"2017","unstructured":"Bjergager MA, Dalhoff K, Kretschmann A, N\u00f8rgaard KB, Mayer P, Cedergreen N (2017) Determining lower threshold concentrations for synergistic effects. Aquat Toxicol 182:79\u201390","journal-title":"Aquat Toxicol"},{"key":"2043_CR6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10408444.2010.543655","volume":"41","author":"A Boobis","year":"2011","unstructured":"Boobis A, Budinsky R, Collie S, Crofton K, Embry M, Felter S, Hertzberg R, Kopp D, Mihlan G, Mumtaz M, Price P, Solomon K, Teuschler L, Yang R, Zaleski R (2011) Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment. Crit Rev Toxicol 41:369\u2013383","journal-title":"Crit Rev Toxicol"},{"key":"2043_CR7","doi-asserted-by":"publisher","unstructured":"Bopp S, Berggren E, Kienzler A, van der Linden S, Worth A (2015) Scientific methodologies for the combined effects of chemicals\u2014a survey and literature review. EUR 27471 EN. doi: 10.2788\/093511 . http:\/\/publications.jrc.ec.europa.eu\/repository\/bitstream\/JRC97522\/jrc_tech_rep_sci%20meth%20for%20mix_final.pdf . Accessed 21 Aug 2017","DOI":"10.2788\/093511"},{"key":"2043_CR8","doi-asserted-by":"publisher","unstructured":"Bopp SK, Kienzler A, van der Linden S, Lamon L, Paini A, Parissis N, Richarz AN, Triebe J, Worth A (2016) Review of case studies on the human and environmental risk assessment of chemical mixtures. EUR 27968 EN. doi: 10.2788\/272583 . http:\/\/publications.jrc.ec.europa.eu\/repository\/bitstream\/JRC102111\/jrc102111_jrc_tech-rep_mix%20case%20studies_2016_vf.pdf . Accessed 21 Aug 2017","DOI":"10.2788\/272583"},{"key":"2043_CR9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jbt.21543","volume":"28","author":"S Bucher","year":"2014","unstructured":"Bucher S, Le Vee M, Jouan E, Fardel O (2014) Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol 28:119\u2013128","journal-title":"J Biochem Mol Toxicol"},{"key":"2043_CR10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fct.2015.06.019","volume":"83","author":"MV Caballero","year":"2015","unstructured":"Caballero MV, Ares I, Mart\u00ednez M, Mart\u00ednez-Larra\u00f1aga MR, Anad\u00f3n A, Mart\u00ednez MA (2015) Fipronil induces CYP isoforms in rats. Food Chem Toxicol 83:215\u2013221","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"2043_CR11","doi-asserted-by":"crossref","first-page":"e96580","DOI":"10.1371\/journal.pone.0096580","volume":"9","author":"N Cedergreen","year":"2014","unstructured":"Cedergreen N (2014) Quantifying synergy: a systematic review of mixture toxicity studies within environmental toxicology. PLoS One 9(5):e96580","journal-title":"PLoS One"},{"key":"2043_CR12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.scitotenv.2012.03.086","volume":"427\u2013428","author":"N Cedergreen","year":"2012","unstructured":"Cedergreen N, S\u00f8rensen H, Svendsen C (2012) Can the joint effect of ternary mixtures be predicted from binary mixture toxicity results? Sci Total Environ 427\u2013428:229\u2013237","journal-title":"Sci Total Environ"},{"issue":"1","key":"2043_CR13","doi-asserted-by":"crossref","first-page":"e0169480","DOI":"10.1371\/journal.pone.0169480","volume":"12","author":"L Chedik","year":"2017","unstructured":"Chedik L, Bruyere A, Le Vee M, Stieger B, Denizot C, Parmentier Y, Potin S, Fardel O (2017) Inhibition of human drug transporter activities by the pyrethroid pesticides allethrin and tetramethrin. PLoS One 12(1):e0169480","journal-title":"PLoS One"},{"key":"2043_CR14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.taap.2014.06.025","volume":"279","author":"V Christen","year":"2014","unstructured":"Christen V, Crettaz P, Fent K (2014) Additive and synergistic antiandrogenic activities of mixtures of azol fungicides and vinclozolin. Toxicol Appl Pharmacol 279:455\u2013466","journal-title":"Toxicol Appl Pharmacol"},{"key":"2043_CR15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.aquatox.2015.12.007","volume":"172","author":"K Dalhoff","year":"2016","unstructured":"Dalhoff K, Gottardi M, Kretschmann A, Cedergreen N (2016) What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna? Aquat Toxicol 172:95\u2013102","journal-title":"Aquat Toxicol"},{"key":"2043_CR16","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/toxsci\/kfu120","volume":"141","author":"G Sousa de","year":"2014","unstructured":"de Sousa G, Nawaz A, Cravedi JP, Rahmani R (2014) A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet. Toxicol Sci 141:234\u2013243","journal-title":"Toxicol Sci"},{"key":"2043_CR17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1124\/dmd.110.034827","volume":"39","author":"ST Dunn","year":"2011","unstructured":"Dunn ST, Hedges L, Sampson KE, Lai Y, Mahabir S, Balogh L, Locuson CW (2011) Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs. Drug Metab Dispos 39:789\u2013795","journal-title":"Drug Metab Dispos"},{"issue":"7","key":"2043_CR18","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.2903\/j.efsa.2013.3313","volume":"11","author":"EFSA (European Food Safety Authority)","year":"2013","unstructured":"EFSA (European Food Safety Authority) (2013a) International framework dealing with human risk assessment of combined exposure to multiple chemicals. EFSA J 11(7):3313","journal-title":"EFSA J"},{"issue":"12","key":"2043_CR19","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.2903\/j.efsa.2013.3472","volume":"11","author":"EFSA (European Food Safety Authority)","year":"2013","unstructured":"EFSA (European Food Safety Authority) (2013b) Scientific Opinion on relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food. EFSA J 11(12):3472","journal-title":"EFSA J"},{"key":"2043_CR20","doi-asserted-by":"publisher","unstructured":"EFSA (European Food Safety Authority) (2017) The 2015 European Union report on pesticide residues in food. EFSA J 15(4). doi: 10.2903\/j.efsa.2017.4791","DOI":"10.2903\/j.efsa.2017.4791"},{"key":"2043_CR21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2013.11.019","volume":"230","author":"B Gonz\u00e1lez-Alzaga","year":"2014","unstructured":"Gonz\u00e1lez-Alzaga B, Lacasa\u00f1a M, Aguilar-Gardu\u00f1o C, Rodr\u00edguez-Barranco M, Ballester F, Rebagliato M, Hern\u00e1ndez AF (2014) A systematic review of neurodevelopmental effects of prenatal and postnatal organophosphate pesticide exposure. Toxicol Lett 230:104\u2013121","journal-title":"Toxicol Lett"},{"key":"2043_CR22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.taap.2016.06.007","volume":"305","author":"S Halwachs","year":"2016","unstructured":"Halwachs S, Sch\u00e4fer I, Kneuer C, Seibel P, Honscha W (2016) Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model. Toxicol Appl Pharmacol 305:66\u201374","journal-title":"Toxicol Appl Pharmacol"},{"key":"2043_CR23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.fct.2017.03.012","volume":"103","author":"AF Hern\u00e1ndez","year":"2017","unstructured":"Hern\u00e1ndez AF, Tsatsakis AM (2017) Human exposure to chemical mixtures: challenges for the integration of toxicology with epidemiology data in risk assessment. Food Chem Toxicol 103:188\u2013193","journal-title":"Food Chem Toxicol"},{"key":"2043_CR24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tox.2012.06.009","volume":"307","author":"AF Hern\u00e1ndez","year":"2013","unstructured":"Hern\u00e1ndez AF, Parr\u00f3n T, Tsatsakis AM, Requena M, Alarc\u00f3n R, L\u00f3pez-Guarnido O (2013) Toxic effects of pesticide mixtures at a molecular level: their relevance to human health. Toxicology 307:136\u2013145","journal-title":"Toxicology"},{"key":"2043_CR25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jbt.20175","volume":"21","author":"E Hodgson","year":"2007","unstructured":"Hodgson E, Rose RL (2007) Human metabolic interactions of environmental chemicals. J Biochem Mol Toxicol 21:182\u2013186","journal-title":"J Biochem Mol Toxicol"},{"key":"2043_CR26","first-page":"57","volume-title":"Anticholinesterase pesticides: metabolism, neurotoxicity, and epidemiology","author":"CJ Jackson","year":"2010","unstructured":"Jackson CJ, Oakeshott JG, Sanchez-Hernandez JC, Wheelock CE (2010) Carboxylesterases in the metabolism and toxicity of pesticides. In: Satoh T, Gupta RC (eds) Anticholinesterase pesticides: metabolism, neurotoxicity, and epidemiology. Wiley, Hoboken, New Jersey, pp 57\u201375"},{"key":"2043_CR27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aquatox.2005.10.001","volume":"76","author":"M Junghans","year":"2006","unstructured":"Junghans M, Backhaus T, Faust M, Scholze T, Grimme LH (2006) Application and validation of approaches for the predictive hazard assessment of realistic pesticide mixtures. Aquat Toxicol 76:93\u2013110","journal-title":"Aquat Toxicol"},{"key":"2043_CR28","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.chemosphere.2017.04.116","volume":"181","author":"A Kadar","year":"2017","unstructured":"Kadar A, de Sousa G, Peyre L, Wortham H, Doumenq P, Rahmani R (2017) Evidence of in vitro metabolic interaction effects of a chlorfenvinphos, ethion and linuron mixture on human hepatic detoxification rates. Chemosphere 181:666\u2013674","journal-title":"Chemosphere"},{"key":"2043_CR29","volume-title":"Assessment of mixtures-review of regulatory requirements and guidance JRC Science and Policy Report European Commission","author":"A Kienzler","year":"2014","unstructured":"Kienzler A, Berggren E, Bessems J, Bopp S, Van Der Linden S, Worth A (2014) Assessment of mixtures-review of regulatory requirements and guidance JRC Science and Policy Report European Commission. Joint Res Center, Ispra"},{"key":"2043_CR30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.yrtph.2016.05.020","volume":"80","author":"A Kienzler","year":"2016","unstructured":"Kienzler A, Bopp SK, van der Linden S, Berggren E, Worth A (2016) Regulatory assessment of chemical mixtures: requirements, current approaches and future perspectives. Regul Toxicol Pharmacol 80:321\u2013334","journal-title":"Regul Toxicol Pharmacol"},{"key":"2043_CR31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2010.11.008","volume":"280","author":"H Kojima","year":"2011","unstructured":"Kojima H, Sata F, Takeuchi S, Sueyoshi T, Nagai T (2011) Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology 280:77\u201387","journal-title":"Toxicology"},{"key":"2043_CR32","unstructured":"Kortenkamp A, Backhaus T, Faust M (2009) State of the art report on mixture toxicity. Directorate General for the Environment: Report to the EU Commission. http:\/\/www.ec.europa.eu\/environment\/chemicals\/effects\/pdf\/report_mixture_toxicity.pdf . Accessed 21 Aug 2007"},{"key":"2043_CR33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jat.1460","volume":"29","author":"ME Letelier","year":"2009","unstructured":"Letelier ME, Fa\u00fandez M, Jara-Sandoval J, Molina-Berr\u00edos A, Cort\u00e9s-Troncoso J, Aracena-Parks P, Mar\u00edn-Catal\u00e1n R (2009) Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions. J Appl Toxicol 29:695\u2013702","journal-title":"J Appl Toxicol"},{"issue":"60","key":"2043_CR34","first-page":"S1","volume":"2011","author":"ME Meek","year":"2011","unstructured":"Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Raaij MV, Vickers C (2011) Risk assessment of combined exposure to multiple chemicals: a WHO\/IPCS framework. Regul Toxicol Pharmacol 2011(60):S1\u2013S14","journal-title":"Regul Toxicol Pharmacol"},{"key":"2043_CR35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuro.2014.01.008","volume":"43","author":"M Meijer","year":"2014","unstructured":"Meijer M, Hamers T, Westerink RH (2014a) Acute disturbance of calcium homeostasis in PC12 cells as a novel mechanism of action for (sub)micromolar concentrations of organophosphate insecticides. Neurotoxicology 43:110\u2013116","journal-title":"Neurotoxicology"},{"key":"2043_CR36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/toxsci\/kfu110","volume":"141","author":"M Meijer","year":"2014","unstructured":"Meijer M, Dingemans MM, van den Berg M, Westerink RH (2014b) Inhibition of voltage-gated calcium channels as common mode of action for (mixtures of) distinct classes of insecticides. Toxicol Sci 141:103\u2013111","journal-title":"Toxicol Sci"},{"key":"2043_CR37","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3109\/15376516.2015.1020182","volume":"25","author":"A Mokarizadeh","year":"2015","unstructured":"Mokarizadeh A, Faryabi MR, Rezvanfar MA, Abdollahi M (2015) A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences. Toxicol Mech Methods 25:258\u2013278","journal-title":"Toxicol Mech Methods"},{"key":"2043_CR38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/074823379200800604","volume":"8","author":"MM Mumtaz","year":"1992","unstructured":"Mumtaz MM, Durkin PR (1992) A weight-of-evidence approach for assessing interactions in chemical mixtures. Toxicol Ind Health 8:377\u2013406","journal-title":"Toxicol Ind Health"},{"key":"2043_CR39","doi-asserted-by":"publisher","unstructured":"Ntzani EE, Chondrogiorgi M, Ntritsos G, Evangelou E, Tzoulaki I (2013) Literature review on epidemiological studies linking exposure to pesticides and health effects. EFSA Supporting Publication, EN-497, New York, 159 p. doi: 10.2903\/sp.efsa.2013.EN-497","DOI":"10.2903\/sp.efsa.2013.EN-497"},{"key":"2043_CR40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2013.09.008","volume":"278","author":"F Orton","year":"2014","unstructured":"Orton F, Ermler S, Kugathas S, Rosivatz E, Scholze M, Kortenkamp A (2014) Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products. Toxicol Appl Pharmacol 278:201\u2013208","journal-title":"Toxicol Appl Pharmacol"},{"key":"2043_CR41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.taap.2011.05.006","volume":"256","author":"T Parr\u00f3n","year":"2011","unstructured":"Parr\u00f3n T, Requena M, Hern\u00e1ndez AF, Alarc\u00f3n R (2011) Association between environmental exposure to pesticides and neurodegenerative diseases. Toxicol Appl Pharmacol 256:379\u2013385","journal-title":"Toxicol Appl Pharmacol"},{"key":"2043_CR42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.toxlet.2013.11.009","volume":"230","author":"T Parr\u00f3n","year":"2014","unstructured":"Parr\u00f3n T, Requena M, Hern\u00e1ndez AF, Alarc\u00f3n R (2014) Environmental exposure to pesticides and cancer risk in multiple human organ systems. Toxicol Lett 230:157\u2013165","journal-title":"Toxicol Lett"},{"key":"2043_CR43","doi-asserted-by":"publisher","unstructured":"Quignot N, B\u00e9chaux C, Amzal B (2015) Data collection on toxicokinetic and toxicodynamic interactions of chemical mixtures for human risk assessment. EFSA Supporting Publication, EN-711, New York, 85 p. doi: 10.2903\/sp.efsa.2015.EN-711","DOI":"10.2903\/sp.efsa.2015.EN-711"},{"key":"2043_CR44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/wcms.1240","volume":"6","author":"AB Raies","year":"2016","unstructured":"Raies AB, Bajic VB (2016) In silico toxicology: computational methods for the prediction of chemical toxicity. Wiley Interdiscip Rev Comput Mol Sci 6:147\u2013172","journal-title":"Wiley Interdiscip Rev Comput Mol Sci"},{"key":"2043_CR45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yrtph.2009.09.013","volume":"56","author":"TK Reffstrup","year":"2010","unstructured":"Reffstrup TK, Larsen JC, Meyer O (2010) Risk assessment of mixtures of pesticides. Current approaches and future strategies. Regul Toxicol Pharmacol 56:174\u2013192","journal-title":"Regul Toxicol Pharmacol"},{"key":"2043_CR46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2605.2009.01049.x","volume":"33","author":"CV Rider","year":"2010","unstructured":"Rider CV, Furr JR, Wilson VS, Gray LE Jr (2010) Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. Int J Androl 33:443\u2013462","journal-title":"Int J Androl"},{"key":"2043_CR47","doi-asserted-by":"crossref","first-page":"9660","DOI":"10.3390\/ijerph110909660","volume":"11","author":"S Rieke","year":"2014","unstructured":"Rieke S, Koehn S, Hirsch-Ernst K, Pfeil R, Kneuer C, Marx-Stoelting P (2014) Combination effects of (tri)azole fungicides on hormone production and xenobiotic metabolism in a human placental cell line. Int J Environ Res Public Health 11:9660\u20139679","journal-title":"Int J Environ Res Public Health"},{"key":"2043_CR48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cbi.2016.06.003","volume":"254","author":"V Rizzati","year":"2016","unstructured":"Rizzati V, Briand O, Guillou H, Gamet-Payrastre L (2016) Effects of pesticide mixtures in human and animal models: an update of the recent literature. Chem Biol Interact 254:231\u2013246","journal-title":"Chem Biol Interact"},{"key":"2043_CR49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/toxics3040342","volume":"3","author":"I Rodea-Palomares","year":"2015","unstructured":"Rodea-Palomares I, Gonz\u00e1lez-Pleiter M, Mart\u00edn-Betancor K, Rosal R, Fern\u00e1ndez-Pi\u00f1as F (2015) Additivity and interactions in ecotoxicity of pollutant mixtures: some patterns, conclusions, and open questions. Toxics 3:342\u2013369","journal-title":"Toxics"},{"key":"2043_CR50","unstructured":"Sams C (2006) A pilot study to assess the effects of co-exposure to organophosphates, carbamates and pyrethroids on the rate of metabolic detoxification via hydrolysis. Project code: T10017. Contractor: Health and Safety Laboratory. http:\/\/www.food.gov.uk\/science\/research\/foodcomponentsresearch\/mixturesresearch\/t10prog\/T10projlist\/t10017project\/ . Accessed 21 Aug 2017"},{"key":"2043_CR51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.toxlet.2010.10.012","volume":"200","author":"C Sams","year":"2011","unstructured":"Sams C, Jones K (2011) Human volunteer studies investigating the potential for toxicokinetic interactions between the pesticides deltamethrin; pirimicarb and chlorpyrifos-methyl following oral exposure at the acceptable daily intake. Toxicol Lett 200:41\u201345","journal-title":"Toxicol Lett"},{"issue":"Suppl 1","key":"2043_CR52","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1186\/1476-069X-11-S1-S18","volume":"11","author":"DA Sarigiannis","year":"2012","unstructured":"Sarigiannis DA, Hansen U (2012) Considering the cumulative risk of mixtures of chemicals-a challenge for policy makers. Environ Health 11(Suppl 1):S18","journal-title":"Environ Health"},{"key":"2043_CR53","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1124\/dmd.114.057786","volume":"42","author":"CC Savary","year":"2014","unstructured":"Savary CC, Joss\u00e9 R, Bruy\u00e8re A, Guillet F, Robin MA, Guillouzo A (2014) Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells. Drug Metab Dispos 42:1235\u20131240","journal-title":"Drug Metab Dispos"},{"key":"2043_CR54","unstructured":"SCHER, SCCS, SCENIHR (2012) Opinion on the toxicity and assessment of chemical mixtures. http:\/\/ec.europa.eu\/health\/scientific_committees\/environmental_risks\/docs\/scher_o_155.pdf . Accessed 21 Aug 2017"},{"key":"2043_CR55","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tox.2016.05.018","volume":"355\u2013356","author":"F Schmidt","year":"2016","unstructured":"Schmidt F, Marx-Stoelting P, Haider W, Heise T, Kneuer C, Ladwig M, Banneke S, Rieke S, Niemann L (2016) Combination effects of azole fungicides in male rats in a broad dose range. Toxicology 355\u2013356:54\u201363","journal-title":"Toxicology"},{"key":"2043_CR56","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/15376516.2016.1218577","volume":"26","author":"A Sultana Shaik","year":"2016","unstructured":"Sultana Shaik A, Shaik AP, Jamil K, Alsaeed AH (2016) Evaluation of cytotoxicity and genotoxicity of pesticide mixtures on lymphocytes. Toxicol Mech Methods 26:588\u2013594","journal-title":"Toxicol Mech Methods"},{"key":"2043_CR57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.toxlet.2013.12.004","volume":"225","author":"H Suzuki","year":"2014","unstructured":"Suzuki H, Ito Y, Noro Y, Koketsu M, Kamijima M, Tomizawa M (2014) Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). Toxicol Lett 225:153\u2013157","journal-title":"Toxicol Lett"},{"key":"2043_CR58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fct.2012.11.011","volume":"52","author":"N Takakura","year":"2013","unstructured":"Takakura N, Sanders P, Fessard V, Le H\u00e9garat L (2013) In vitro combined cytotoxic effects of pesticide cocktails simultaneously found in the French diet. Food Chem Toxicol 52:153\u2013162","journal-title":"Food Chem Toxicol"},{"key":"2043_CR59","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.chemosphere.2012.03.043","volume":"88","author":"D Tian","year":"2012","unstructured":"Tian D, Lin Z, Yu J, Yin D (2012) Influence factors of multicomponent mixtures containing reactive chemicals and their joint effects. Chemosphere 88:994\u20131000","journal-title":"Chemosphere"},{"key":"2043_CR60","unstructured":"US-EPA (U.S. Environmental Protection Agency) (2007) Considerations for developing a dosimetry-based cumulative risk assessment approach for mixtures of environmental contaminants. National Center for Environmental Assessment, Cincinnati, OH. EPA\/600\/R-07\/064, 2007"},{"key":"2043_CR61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cbi.2017.04.023","volume":"272","author":"P Wang","year":"2017","unstructured":"Wang P, Xu MY, Liang YJ, Wang HP, Sun YJ, Long DX, Wu YJ (2017) Subchronic toxicity of low dose propoxur, permethrin, and their combination on the redox status of rat liver. Chem Biol Interact 272:21\u201327","journal-title":"Chem Biol Interact"},{"key":"2043_CR62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/eesa.1995.1039","volume":"31","author":"MS Warne","year":"1995","unstructured":"Warne MS, Hawker DW (1995) The number of components in a mixture determines whether synergistic and antagonistic or additive toxicity predominate: the funnel hypothesis. Ecotoxicol Environ Saf 31:23\u201328","journal-title":"Ecotoxicol Environ Saf"},{"key":"2043_CR63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tox.2017.04.008","volume":"384","author":"MY Xu","year":"2017","unstructured":"Xu MY, Wang P, Sun YJ, Wu YJ (2017) Metabolomic analysis for combined hepatotoxicity of chlorpyrifos and cadmium in rats. Toxicology 384:50\u201358","journal-title":"Toxicology"},{"issue":"3","key":"2043_CR64","doi-asserted-by":"crossref","first-page":"e0151904","DOI":"10.1371\/journal.pone.0151904","volume":"11","author":"Y Yagdiran","year":"2016","unstructured":"Yagdiran Y, Oskarsson A, Knight CH, Tallkvist J (2016) ABC- and SLC-transporters in murine and bovine mammary epithelium-effects of prochloraz. PLoS One 11(3):e0151904","journal-title":"PLoS One"},{"key":"2043_CR65","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cbi.2004.01.006","volume":"147","author":"L You","year":"2004","unstructured":"You L (2004) Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. Chem Biol Interact 147:233\u2013246","journal-title":"Chem Biol Interact"},{"key":"2043_CR66","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jhazmat.2017.03.055","volume":"334","author":"J Zhang","year":"2017","unstructured":"Zhang J, Liu L, Ren L, Feng W, Lv P, Wu W, Yan Y (2017) The single and joint toxicity effects of chlorpyrifos and beta-cypermethrin in zebrafish (Danio rerio) early life stages. J Hazard Mater 334:121\u2013131","journal-title":"J Hazard Mater"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-017-2043-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2043-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2043-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:39:17Z","timestamp":1750808357000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-017-2043-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["2043"],"URL":"https:\/\/doi.org\/10.1007\/s00204-017-2043-5","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}