{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:19:42Z","timestamp":1790957982855,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["DETECTIVE"],"award-info":[{"award-number":["DETECTIVE"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1007\/s00204-017-2065-z","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T10:49:36Z","timestamp":1506077376000},"page":"371-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes"],"prefix":"10.1007","volume":"92","author":[{"given":"Umesh","family":"Chaudhari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshal","family":"Nemade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima","family":"Sureshkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Vinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Ates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Rogiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hescheler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Georg","family":"Hengstler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agapios","family":"Sachinidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,22]]},"reference":[{"key":"2065_CR1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.scitotenv.2007.12.006","volume":"393","author":"M Allmyr","year":"2008","unstructured":"Allmyr M, Harden F, Toms LM, Mueller JF, McLachlan MS, Adolfsson-Erici M, Sandborgh-Englund G (2008) The influence of age and gender on triclosan concentrations in Australian human blood serum. Sci Total Environ 393:162\u2013167","journal-title":"Sci Total Environ"},{"key":"2065_CR2","doi-asserted-by":"crossref","first-page":"244s","DOI":"10.1177\/1091581810385956","volume":"29","author":"CL Burnett","year":"2010","unstructured":"Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA (2010) Final report of the safety assessment of Kojic acid as used in cosmetics. Int J Toxicol 29:244s\u2013273s","journal-title":"Int J Toxicol"},{"key":"2065_CR3","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1007\/s00204-016-1668-0","volume":"90","author":"U Chaudhari","year":"2016","unstructured":"Chaudhari U, Nemade H, Gaspar JA, Hescheler J, Hengstler JG, Sachinidis A (2016a) MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol 90:3087\u20133098","journal-title":"Arch Toxicol"},{"key":"2065_CR4","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1007\/s00204-015-1623-5","volume":"90","author":"U Chaudhari","year":"2016","unstructured":"Chaudhari U, Nemade H, Wagh V, Gaspar JA, Ellis JK, Srinivasan SP, Spitkovski D, Nguemo F, Louisse J, Bremer S, Hescheler J, Keun HC, Hengstler JG, Sachinidis A (2016b) Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol 90:2763\u20132777","journal-title":"Arch Toxicol"},{"key":"2065_CR5","doi-asserted-by":"crossref","first-page":"14158","DOI":"10.1073\/pnas.1211314109","volume":"109","author":"G Cherednichenko","year":"2012","unstructured":"Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN (2012) Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci USA 109:14158\u201314163","journal-title":"Proc Natl Acad Sci USA"},{"key":"2065_CR6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/sj.mt.6300003","volume":"15","author":"K Dardousis","year":"2007","unstructured":"Dardousis K, Voolstra C, Roengvoraphoj M, Sekandarzad A, Mesghenna S, Winkler J, Ko Y, Hescheler J, Sachinidis A (2007) Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. Mol Ther 15:94\u2013102","journal-title":"Mol Ther"},{"key":"2065_CR7","doi-asserted-by":"crossref","first-page":"e40288","DOI":"10.1371\/journal.pone.0040288","volume":"7","author":"MX Doss","year":"2012","unstructured":"Doss MX, Di Diego JM, Goodrow RJ, Wu Y, Cordeiro JM, Nesterenko VV, Barajas-Martinez H, Hu D, Urrutia J, Desai M, Treat JA, Sachinidis A, Antzelevitch C (2012) Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr). PLoS One 7:e40288","journal-title":"PLoS One"},{"key":"2065_CR8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-0536.1997.tb00014.x","volume":"36","author":"A Eskelinen","year":"1997","unstructured":"Eskelinen A, Molitor C, Kanerva L (1997) Allergic contact dermatitis from 2,7-dihydroxynaphthalene in hair dye. Contact Dermat 36:312\u2013313","journal-title":"Contact Dermat"},{"key":"2065_CR9","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0735-1097(99)00006-6","volume":"33","author":"J Feenstra","year":"1999","unstructured":"Feenstra J, Grobbee DE, Remme WJ, Stricker BH (1999) Drug-induced heart failure. J Am Coll Cardiol 33:1152\u20131162","journal-title":"J Am Coll Cardiol"},{"key":"2065_CR10","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1161\/CIRCRESAHA.113.302021","volume":"114","author":"JA Gaspar","year":"2014","unstructured":"Gaspar JA, Doss MX, Hengstler JG, Cadenas C, Hescheler J, Sachinidis A (2014) Unique metabolic features of stem cells, cardiomyocytes, and their progenitors. Circ Res 114:1346\u20131360","journal-title":"Circ Res"},{"key":"2065_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5021\/ad.2012.24.1.1","volume":"24","author":"H Kim","year":"2012","unstructured":"Kim H, Choi HR, Kim DS, Park KC (2012) Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action. Ann Dermatol 24:1\u20136","journal-title":"Ann Dermatol"},{"key":"2065_CR12","first-page":"215","volume":"13","author":"YJ Lin","year":"2000","unstructured":"Lin YJ (2000) Buccal absorption of triclosan following topical mouthrinse application. Am J Dent 13:215\u2013217","journal-title":"Am J Dent"},{"key":"2065_CR13","first-page":"13","volume":"7","author":"YJ Lin","year":"1994","unstructured":"Lin YJ, Fung KK, Kong BM, DeSalva SJ (1994) Gingival absorption of triclosan following topical mouthrinse application. Am J Dent 7:13\u201316","journal-title":"Am J Dent"},{"key":"2065_CR14","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1007\/s11356-014-2968-7","volume":"21","author":"B Manjunatha","year":"2014","unstructured":"Manjunatha B, Wei-bing P, Ke-chun L, Marigoudar SR, Xi-qiang C, Xi-min W, Xue W (2014) The effects of henna (hair dye) on the embryonic development of zebrafish (Danio rerio). Environ Sci Pollut Res Int 21:10361\u201310367","journal-title":"Environ Sci Pollut Res Int"},{"key":"2065_CR15","doi-asserted-by":"crossref","first-page":"e44228","DOI":"10.1371\/journal.pone.0044228","volume":"7","author":"K Meganathan","year":"2012","unstructured":"Meganathan K, Jagtap S, Wagh V, Winkler J, Gaspar JA, Hildebrand D, Trusch M, Lehmann K, Hescheler J, Schluter H, Sachinidis A (2012) Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells. PLoS One 7:e44228","journal-title":"PLoS One"},{"key":"2065_CR16","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.chemosphere.2010.02.002","volume":"79","author":"M Nassef","year":"2010","unstructured":"Nassef M, Kim SG, Seki M, Kang IJ, Hano T, Shimasaki Y, Oshima Y (2010) In ovo nanoinjection of triclosan, diclofenac and carbamazepine affects embryonic development of medaka fish (Oryzias latipes). Chemosphere 79:966\u2013973","journal-title":"Chemosphere"},{"key":"2065_CR17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s11356-009-0119-3","volume":"16","author":"R Oliveira","year":"2009","unstructured":"Oliveira R, Domingues I, Koppe Grisolia C, Soares AM (2009) Effects of triclosan on zebrafish early-life stages and adults. Environ Sci Pollut Res Int 16:679\u2013688","journal-title":"Environ Sci Pollut Res Int"},{"key":"2065_CR18","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1098\/rsif.2010.0541","volume":"8","author":"M Orsi","year":"2011","unstructured":"Orsi M, Noro MG, Essex JW (2011) Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes. J R Soc Interface 8:826\u2013841","journal-title":"J R Soc Interface"},{"key":"2065_CR19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00002018-200022040-00002","volume":"22","author":"VB Pai","year":"2000","unstructured":"Pai VB, Nahata MC (2000) Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf 22:263\u2013302","journal-title":"Drug Saf"},{"key":"2065_CR20","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1021\/es501100w","volume":"48","author":"BF Pycke","year":"2014","unstructured":"Pycke BF, Geer LA, Dalloul M, Abulafia O, Jenck AM, Halden RU (2014) Human fetal exposure to triclosan and triclocarban in an urban population from Brooklyn, New York. Environ Sci Technol 48:8831\u20138838","journal-title":"Environ Sci Technol"},{"key":"2065_CR21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/zeb.2016.1257","volume":"13","author":"A Saley","year":"2016","unstructured":"Saley A, Hess M, Miller K, Howard D, King-Heiden TC (2016) Cardiac toxicity of triclosan in developing zebrafish. Zebrafish 13:399\u2013404","journal-title":"Zebrafish"},{"key":"2065_CR22","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/15287390600631706","volume":"69","author":"G Sandborgh-Englund","year":"2006","unstructured":"Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J (2006) Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A 69:1861\u20131873","journal-title":"J Toxicol Environ Health A"},{"key":"2065_CR23","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/jat.3311","volume":"36","author":"J Shim","year":"2016","unstructured":"Shim J, Weatherly LM, Luc RH, Dorman MT, Neilson A, Ng R, Kim CH, Millard PJ, Gosse JA (2016) Triclosan is a mitochondrial uncoupler in live zebrafish. J Appl Toxicol 36:1662\u20131667","journal-title":"J Appl Toxicol"},{"key":"2065_CR24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.lungcan.2013.08.010","volume":"82","author":"N Shirsath","year":"2013","unstructured":"Shirsath N, Rathos M, Chaudhari U, Sivaramakrishnan H, Joshi K (2013) Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines. Lung Cancer 82:214\u2013221","journal-title":"Lung Cancer"},{"key":"2065_CR25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tox.2008.08.001","volume":"252","author":"TC Stummann","year":"2008","unstructured":"Stummann TC, Hareng L, Bremer S (2008) Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells. Toxicology 252:118\u2013122","journal-title":"Toxicology"},{"key":"2065_CR26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.fct.2015.09.010","volume":"86","author":"Y Tafurt-Cardona","year":"2015","unstructured":"Tafurt-Cardona Y, Suares-Rocha P, Fernandes TC, Marin-Morales MA (2015) Cytotoxic and genotoxic effects of two hair dyes used in the formulation of black color. Food Chem Toxicol 86:9\u201315","journal-title":"Food Chem Toxicol"},{"key":"2065_CR27","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1021\/tx400402j","volume":"27","author":"T Waldmann","year":"2014","unstructured":"Waldmann T, Rempel E, Balmer NV, Konig A, Kolde R, Gaspar JA, Henry M, Hescheler J, Sachinidis A, Rahnenfuhrer J, Hengstler JG, Leist M (2014) Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol 27:408\u2013420","journal-title":"Chem Res Toxicol"},{"key":"2065_CR28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/jat.3209","volume":"36","author":"LM Weatherly","year":"2016","unstructured":"Weatherly LM, Shim J, Hashmi HN, Kennedy RH, Hess ST, Gosse JA (2016) Antimicrobial agent triclosan is a proton ionophore uncoupler of mitochondria in living rat and human mast cells and in primary human keratinocytes. J Appl Toxicol 36:777\u2013789","journal-title":"J Appl Toxicol"},{"key":"2065_CR29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cca.2016.12.024","volume":"466","author":"L Wei","year":"2017","unstructured":"Wei L, Qiao P, Shi Y, Ruan Y, Yin J, Wu Q, Shao B (2017) Triclosan\/triclocarban levels in maternal and umbilical blood samples and their association with fetal malformation. Clin Chim Acta 466:133\u2013137","journal-title":"Clin Chim Acta"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-017-2065-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2065-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2065-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T01:38:38Z","timestamp":1516239518000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-017-2065-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,22]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["2065"],"URL":"https:\/\/doi.org\/10.1007\/s00204-017-2065-z","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,22]]}}}