{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:54:11Z","timestamp":1777535651419,"version":"3.51.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T00:00:00Z","timestamp":1508112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U54NS079202"],"award-info":[{"award-number":["U54NS079202"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM099608"],"award-info":[{"award-number":["T32GM099608"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00204-017-2089-4","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T11:50:58Z","timestamp":1508154658000},"page":"833-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS"],"prefix":"10.1007","volume":"92","author":[{"given":"Brandon","family":"Pressly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai M.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-5763","authenticated-orcid":false,"given":"Heike","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,16]]},"reference":[{"issue":"4","key":"2089_CR1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1523\/JNEUROSCI.13-04-01418.1993","volume":"13","author":"TP Angelotti","year":"1993","unstructured":"Angelotti TP, Uhler MD, Macdonald RL (1993) Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate\/marker gene technique. J Neurosci 13(4):1418\u20131428","journal-title":"J Neurosci"},{"key":"2089_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201700783","author":"B Barnych","year":"2017","unstructured":"Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen H, Cajka T, Pessah I, Wulff H, Gee S, Hammock B (2017) Development of tetramethylenedisulfotetramine (TETS) hapten library: synthesis, electrophysiological studies and immune response in rabbits. Chemistry. doi: 10.1002\/chem.201700783","journal-title":"Chemistry"},{"issue":"7","key":"2089_CR3","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1081\/CLT-120026523","volume":"41","author":"F Barrueto Jr","year":"2003","unstructured":"Barrueto F Jr, Furdyna PM, Hoffman RS, Hoffman RJ, Nelson LS (2003) Status epilepticus from an illegally imported Chinese rodenticide: \u201ctetramine\u201d. J Toxicol Clin Toxicol 41(7):991\u2013994","journal-title":"J Toxicol Clin Toxicol"},{"issue":"1","key":"2089_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1124\/jpet.102.042960","volume":"304","author":"YA Blednov","year":"2003","unstructured":"Blednov YA, Jung S, Alva H, Wallace D, Rosahl T, Whiting PJ, Harris RA (2003) Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J Pharmacol Exp Ther 304(1):30\u201336. doi: 10.1124\/jpet.102.042960","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"2089_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1476-5381.1975.tb07379.x","volume":"53","author":"NG Bowery","year":"1975","unstructured":"Bowery NG, Brown DA, Collins JF (1975) Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat. Br J Pharmacol 53(3):422\u2013424","journal-title":"Br J Pharmacol"},{"issue":"2","key":"2089_CR6","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1093\/toxsci\/kfs244","volume":"130","author":"Z Cao","year":"2012","unstructured":"Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN (2012) Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362\u2013372. doi: 10.1093\/toxsci\/kfs244","journal-title":"Toxicol Sci"},{"issue":"2","key":"2089_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0041-008X(76)90006-5","volume":"36","author":"JE Casida","year":"1976","unstructured":"Casida JE, Eto M, Moscioni AD, Engel JL, Milbrath DS, Verkade JG (1976) Structure-toxicity relationships of 2,6,7-trioxabicyclo(2.2.2)octanes and related compounds. Toxicol Appl Pharmacol 36(2):261\u2013279","journal-title":"Toxicol Appl Pharmacol"},{"issue":"13","key":"2089_CR8","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1073\/pnas.0600370103","volume":"103","author":"L Chen","year":"2006","unstructured":"Chen L, Durkin KA, Casida JE (2006) Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site. Proc Natl Acad Sci USA 103(13):5185\u20135190. doi: 10.1073\/pnas.0600370103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"2089_CR9","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1523\/JNEUROSCI.22-13-05572.2002","volume":"22","author":"N Collinson","year":"2002","unstructured":"Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, Smith A, Otu FM, Howell O, Atack JR, McKernan RM, Seabrook GR, Dawson GR, Whiting PJ, Rosahl TW (2002) Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. J Neurosci 22(13):5572\u20135580","journal-title":"J Neurosci"},{"issue":"20","key":"2089_CR10","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1523\/JNEUROSCI.18-20-08505.1998","volume":"18","author":"TM DeLorey","year":"1998","unstructured":"DeLorey TM, Handforth A, Anagnostaras SG, Homanics GE, Minassian BA, Asatourian A, Fanselow MS, Delgado-Escueta A, Ellison GD, Olsen RW (1998) Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci 18(20):8505\u20138514","journal-title":"J Neurosci"},{"issue":"2","key":"2089_CR11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1021\/tx00020a007","volume":"4","author":"T Esser","year":"1991","unstructured":"Esser T, Karu AE, Toia RF, Casida JE (1991) Recognition of tetramethylenedisulfotetramine and related sulfamides by the brain GABA-gated chloride channel and a cyclodiene-sensitive monoclonal antibody. Chem Res Toxicol 4(2):162\u2013167","journal-title":"Chem Res Toxicol"},{"issue":"4","key":"2089_CR12","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1177\/0269881106067255","volume":"21","author":"RL Fradley","year":"2007","unstructured":"Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O\u2019Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR (2007) Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. J Psychopharmacol 21(4):384\u2013391. doi: 10.1177\/0269881106067255","journal-title":"J Psychopharmacol"},{"issue":"1","key":"2089_CR13","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/cne.903590111","volume":"359","author":"JM Fritschy","year":"1995","unstructured":"Fritschy JM, Mohler H (1995) GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359(1):154\u2013194. doi: 10.1002\/cne.903590111","journal-title":"J Comp Neurol"},{"issue":"4","key":"2089_CR14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/jat\/17.4.199","volume":"17","author":"FY Guan","year":"1993","unstructured":"Guan FY, Liu YT, Luo Y, Hu XY, Liu F, Li QY, Kang ZW (1993) GC\/MS identification of tetramine in samples from human alimentary intoxication and evaluation of artificial carbonic kidneys for the treatment of the victims. J Anal Toxicol 17(4):199\u2013201","journal-title":"J Anal Toxicol"},{"key":"2089_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1055\/s-0028-1117825","volume":"75","author":"J Hagen","year":"1950","unstructured":"Hagen J (1950) Schwere Vergiftungen in Liner Polsterm\u00f6belfabrik durch einen neuartigen hoch toxischen Giftstoff (Tetramethylendisulfotetramin). Dtsch Med Wochenschr 75:183\u2013184","journal-title":"Dtsch Med Wochenschr"},{"issue":"12","key":"2089_CR16","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1111\/j.1528-1167.2005.00287.x","volume":"46","author":"A Handforth","year":"2005","unstructured":"Handforth A, Delorey TM, Homanics GE, Olsen RW (2005) Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome. Epilepsia 46(12):1860\u20131870. doi: 10.1111\/j.1528-1167.2005.00287.x","journal-title":"Epilepsia"},{"issue":"4","key":"2089_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/jps.3030460412","volume":"46","author":"AR Haskell","year":"1957","unstructured":"Haskell AR, Voss E (1957) The pharmacology of tetramine (tetraethylenedisulfotetramine). J Am Pharm Assoc Am Pharm Assoc 46(4):239\u2013242","journal-title":"J Am Pharm Assoc Am Pharm Assoc"},{"issue":"7349","key":"2089_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nature10139","volume":"474","author":"RE Hibbs","year":"2011","unstructured":"Hibbs RE, Gouaux E (2011) Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature 474(7349):54\u201360. doi: 10.1038\/nature10139","journal-title":"Nature"},{"issue":"2","key":"2089_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/bph.12127","volume":"169","author":"GA Johnston","year":"2013","unstructured":"Johnston GA (2013) Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol 169(2):328\u2013336. doi: 10.1111\/bph.12127","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2089_CR20","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1523\/JNEUROSCI.17-04-01350.1997","volume":"17","author":"A Jones","year":"1997","unstructured":"Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Makela R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W (1997) Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression. J Neurosci 17(4):1350\u20131362","journal-title":"J Neurosci"},{"issue":"4","key":"2089_CR21","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1046\/j.1471-4159.1994.63041466.x","volume":"63","author":"ZU Khan","year":"1994","unstructured":"Khan ZU, Guti\u00e9rrez A, De Blas AL (1994) Short and long form gamma 2 subunits of the GABAA\/benzodiazepine receptors. J Neurochem 63(4):1466\u20131476","journal-title":"J Neurochem"},{"issue":"8","key":"2089_CR22","doi-asserted-by":"publisher","first-page":"2780","DOI":"10.1039\/c3ay41912f","volume":"6","author":"JS Knaack","year":"2014","unstructured":"Knaack JS, Hamelin EI, Magnuson M, Silvestri E, Ash D, Johnson RC (2014) Quantitative analysis and stability of the rodenticide TETS (tetramine) in finished tap water. Anal Methods UK 6(8):2780\u20132784","journal-title":"Anal Methods UK"},{"key":"2089_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/bs.apha.2014.10.003","volume":"72","author":"J Krall","year":"2015","unstructured":"Krall J, Balle T, Krogsgaard-Larsen N, Sorensen TE, Krogsgaard-Larsen P, Kristiansen U, Frolund B (2015) GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology. Adv Pharmacol 72:201\u2013227. doi: 10.1016\/bs.apha.2014.10.003","journal-title":"Adv Pharmacol"},{"issue":"3","key":"2089_CR24","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0041-008X(68)90104-X","volume":"13","author":"C Lamanna","year":"1968","unstructured":"Lamanna C, Hart ER (1968) Relationship of lethal toxic dose to body weight of the mouse. Toxicol Appl Pharmacol 13(3):307\u2013315","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7514","key":"2089_CR25","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/nature13293","volume":"512","author":"PS Miller","year":"2014","unstructured":"Miller PS, Aricescu AR (2014) Crystal structure of a human GABAA receptor. Nature 512(7514):270\u2013275. doi: 10.1038\/nature13293","journal-title":"Nature"},{"issue":"1","key":"2089_CR26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1124\/jpet.300.1.2","volume":"300","author":"H Mohler","year":"2002","unstructured":"Mohler H, Fritschy JM, Rudolph U (2002) A new benzodiazepine pharmacology. J Pharmacol Exp Ther 300(1):2\u20138","journal-title":"J Pharmacol Exp Ther"},{"issue":"Pt 8","key":"2089_CR27","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1113\/jphysiol.2009.182444","volume":"588","author":"M Mortensen","year":"2010","unstructured":"Mortensen M, Ebert B, Wafford K, Smart TG (2010) Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. J Physiol 588(Pt 8):1251\u20131268. doi: 10.1113\/jphysiol.2009.182444","journal-title":"J Physiol"},{"key":"2089_CR28","first-page":"1","volume":"6","author":"M Mortensen","year":"2011","unstructured":"Mortensen M, Patel B, Smart TG (2011) GABA potency at GABA(A) receptors found in synaptic and extrasynaptic zones. Front Cell Neurosci 6:1","journal-title":"Front Cell Neurosci"},{"key":"2089_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/bs.apha.2014.11.005","volume":"73","author":"RW Olsen","year":"2015","unstructured":"Olsen RW (2015) Allosteric ligands and their binding sites define gamma-aminobutyric acid (GABA) type A receptor subtypes. Adv Pharmacol 73:167\u2013202. doi: 10.1016\/bs.apha.2014.11.005","journal-title":"Adv Pharmacol"},{"issue":"3","key":"2089_CR30","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1124\/pr.108.00505","volume":"60","author":"RW Olsen","year":"2008","unstructured":"Olsen RW, Sieghart W (2008) International Union of pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 60(3):243\u2013260. doi: 10.1124\/pr.108.00505","journal-title":"Pharmacol Rev"},{"issue":"1","key":"2089_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuropharm.2008.07.045","volume":"56","author":"RW Olsen","year":"2009","unstructured":"Olsen RW, Sieghart W (2009) GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology 56(1):141\u2013148. doi: 10.1016\/j.neuropharm.2008.07.045","journal-title":"Neuropharmacology"},{"issue":"1","key":"2089_CR32","first-page":"66","volume":"21","author":"G Pervukhin","year":"1989","unstructured":"Pervukhin G, Sharonova IN, Prokof\u2019ev SE, Fedorov NB, Kotel\u2019nikov SA (1989) Effect of the gamma-aminobutyric acid antagonist disulfotetraazaadamantane on the evoked responses of neurons in hippocampal slices. Neirofiziologiia 21(1):66\u201370","journal-title":"Neirofiziologiia"},{"issue":"4","key":"2089_CR33","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0306-4522(00)00442-5","volume":"101","author":"S Pirker","year":"2000","unstructured":"Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G (2000) GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101(4):815\u2013850","journal-title":"Neuroscience"},{"issue":"3","key":"2089_CR34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1006\/taap.2001.9154","volume":"172","author":"GS Ratra","year":"2001","unstructured":"Ratra GS, Kamita SG, Casida JE (2001) Role of human GABA(A) receptor beta3 subunit in insecticide toxicity. Toxicol Appl Pharmacol 172(3):233\u2013240. doi: 10.1006\/taap.2001.9154","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9","key":"2089_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrd3502","volume":"10","author":"U Rudolph","year":"2011","unstructured":"Rudolph U, Knoflach F (2011) Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov 10(9):685\u2013697. doi: 10.1038\/nrd3502","journal-title":"Nat Rev Drug Discov"},{"key":"2089_CR36","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1146\/annurev.pharmtox.44.101802.121429","volume":"44","author":"U Rudolph","year":"2004","unstructured":"Rudolph U, Mohler H (2004) Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 44:475\u2013498. doi: 10.1146\/annurev.pharmtox.44.101802.121429","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3","key":"2089_CR37","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1528-1157.1996.tb00024.x","volume":"37","author":"AA Shandra","year":"1996","unstructured":"Shandra AA, Mazarati AM, Godlevsky LS, Vastyanov RS (1996) Chemical kindling: implications for antiepileptic drugs\u2014sensitive and resistant epilepsy models. Epilepsia 37(3):269\u2013274","journal-title":"Epilepsia"},{"issue":"4243","key":"2089_CR38","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/167324a0","volume":"167","author":"SN Slater","year":"1951","unstructured":"Slater SN, Wilson AT (1951) Relationship between picrotin and picrotoxinin. Nature 167(4243):324\u2013325","journal-title":"Nature"},{"issue":"2","key":"2089_CR39","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0026-895X(25)14273-9","volume":"23","author":"RF Squires","year":"1983","unstructured":"Squires RF, Casida JE, Richardson M, Saederup E (1983) [35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites. Mol Pharmacol 23(2):326\u2013336","journal-title":"Mol Pharmacol"},{"issue":"10","key":"2089_CR40","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1523\/JNEUROSCI.21-10-03409.2001","volume":"21","author":"C Sur","year":"2001","unstructured":"Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O\u2019Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, Rosahl TW (2001) Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci 21(10):3409\u20133418","journal-title":"J Neurosci"},{"issue":"10","key":"2089_CR41","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1021\/acs.analchem.7b00846","volume":"89","author":"N Vasylieva","year":"2017","unstructured":"Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD (2017) Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine. Anal Chem 89(10):5612\u20135619. doi: 10.1021\/acs.analchem.7b00846","journal-title":"Anal Chem"},{"issue":"6","key":"2089_CR42","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.annemergmed.2004.09.009","volume":"45","author":"KS Whitlow","year":"2005","unstructured":"Whitlow KS, Belson M, Barrueto F, Nelson L, Henderson AK (2005) Tetramethylenedisulfotetramine: old agent and new terror. Ann Emerg Med 45(6):609\u2013613. doi: 10.1016\/j.annemergmed.2004.09.009","journal-title":"Ann Emerg Med"},{"key":"2089_CR43","first-page":"346","volume":"56","author":"FC Wood","year":"1933","unstructured":"Wood FC, Battye AE (1933) The condensation of sulphamide, dimethylsulphamide, and aniline-p-sulphonamide with formaldehyde. J Soc Chem Ind 56:346\u2013349","journal-title":"J Soc Chem Ind"},{"issue":"1\u20133","key":"2089_CR44","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.1016\/j.forsciint.2010.06.025","volume":"204","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Su M, Tian DP (2011) Tetramine poisoning: a case report and review of the literature. Forensic Sci Int 204(1\u20133):e24\u2013e27. doi: 10.1016\/j.forsciint.2010.06.025","journal-title":"Forensic Sci Int"},{"issue":"23","key":"2089_CR45","doi-asserted-by":"publisher","first-page":"8607","DOI":"10.1073\/pnas.1407379111","volume":"111","author":"C Zhao","year":"2014","unstructured":"Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone FC, Yang J, Hammock BD, Casida JE (2014) GABAA receptor target of tetramethylenedisulfotetramine. Proc Natl Acad Sci USA 111(23):8607\u20138612. doi: 10.1073\/pnas.1407379111","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2089_CR46","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1124\/jpet.111.190579","volume":"341","author":"D Zolkowska","year":"2012","unstructured":"Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA (2012) Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther 341(2):435\u2013446. doi: 10.1124\/jpet.111.190579","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-017-2089-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2089-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-017-2089-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:18:37Z","timestamp":1750947517000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-017-2089-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,16]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["2089"],"URL":"https:\/\/doi.org\/10.1007\/s00204-017-2089-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,16]]},"assertion":[{"value":"16 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work was supported by the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Neurological Disorders and Stroke [U54NS079202]. Brandon Pressly was supported by a National Institute of General Medical Sciences funded Pharmacology Training Program [T32GM099608].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}}]}}