{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:08:17Z","timestamp":1783717697929,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T00:00:00Z","timestamp":1527897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570618"],"award-info":[{"award-number":["81570618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Support Program of China","award":["2013BAH05F02"],"award-info":[{"award-number":["2013BAH05F02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00204-018-2225-9","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T11:51:46Z","timestamp":1527940306000},"page":"2245-2257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model"],"prefix":"10.1007","volume":"92","author":[{"given":"Wei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-3754","authenticated-orcid":false,"given":"Shao-Bin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"issue":"3","key":"2225_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00204-010-0626-5","volume":"85","author":"C Briguori","year":"2011","unstructured":"Briguori C, Quintavalle C, De Micco F, Condorelli G (2011) Nephrotoxicity of contrast media and protective effects of acetylcysteine. Arch Toxicol 85(3):165\u201373. \n                    https:\/\/doi.org\/10.1007\/s00204-010-0626-5","journal-title":"Arch Toxicol"},{"key":"2225_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ijcard.2016.02.086","volume":"210","author":"M Centola","year":"2016","unstructured":"Centola M, Lucreziotti S, Salerno-Uriarte D et al (2016) A comparison between two different definitions of contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Int J Cardiol 210:4\u20139. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2016.02.086","journal-title":"Int J Cardiol"},{"issue":"4","key":"2225_CR3","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/00004424-198307000-00015","volume":"18","author":"PB Dean","year":"1983","unstructured":"Dean PB, Kivisaari L, Kormano M (1983) Contrast enhancement pharmacokinetics of six ionic and nonionic contrast media. Invest Radiol 18(4):368\u201374","journal-title":"Invest Radiol"},{"issue":"5","key":"2225_CR4","first-page":"503","volume":"41","author":"SB Duan","year":"2000","unstructured":"Duan SB, Liu FY, Luo JA et al (2000) Nephrotoxicity of high- and low-osmolar contrast media. The protective role of amlodipine in a rat model. Acta Radiol 41(5):503\u2013507","journal-title":"Acta Radiol"},{"issue":"6","key":"2225_CR5","first-page":"717","volume":"19","author":"S Duan","year":"2006","unstructured":"Duan S, Zhou X, Liu F et al (2006) Comparative cytotoxicity of high-osmolar and low-osmolar contrast media on HKCs in vitro. J Nephrol 19(6):717\u201324","journal-title":"J Nephrol"},{"key":"2225_CR6","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ceb.2015.01.002","volume":"33","author":"A Eiyama","year":"2015","unstructured":"Eiyama A, Okamoto K (2015) PINK1\/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol 33:95\u2013101. \n                    https:\/\/doi.org\/10.1016\/j.ceb.2015.01.002","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"2225_CR7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nrneph.2015.214","volume":"12","author":"F Emma","year":"2016","unstructured":"Emma F, Montini G, Parikh SM, Salviati L (2016) Mitochondrial dysfunction in inherited renal disease and acute kidney injury. Nat Rev Nephrol 12(5):267\u201380. \n                    https:\/\/doi.org\/10.1038\/nrneph.2015.214","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"2225_CR8","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/ki.2012.328","volume":"83","author":"AM Hall","year":"2013","unstructured":"Hall AM, Rhodes GJ, Sandoval RM, Corridon PR, Molitoris BA (2013) In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury. Kidney Int 83(1):72\u201383. \n                    https:\/\/doi.org\/10.1038\/ki.2012.328","journal-title":"Kidney Int"},{"key":"2225_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/0284185195036S39909","volume":"399","author":"IF Heglund","year":"1995","unstructured":"Heglund IF, Michelet AA, Blazak WF, Furuhama K, Holtz E (1995) Preclinical pharmacokinetics and general toxicology of iodixanol. Acta Radiol Suppl 399:69\u201382","journal-title":"Acta Radiol Suppl"},{"issue":"1","key":"2225_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/SHK.0000000000000830","volume":"48","author":"Q Hu","year":"2017","unstructured":"Hu Q, Ren J, Wu J et al (2017) Urinary mitochondrial DNA levels identify acute kidney injury in surgical critical illness patients. Shock 48(1):11\u201317. \n                    https:\/\/doi.org\/10.1097\/SHK.0000000000000830","journal-title":"Shock"},{"issue":"4","key":"2225_CR11","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.kint.2015.11.021","volume":"89","author":"GP Kaushal","year":"2016","unstructured":"Kaushal GP, Shah SV (2016) Autophagy in acute kidney injury. Kidney Int 89(4):779\u201391. \n                    https:\/\/doi.org\/10.1016\/j.kint.2015.11.021","journal-title":"Kidney Int"},{"issue":"1","key":"2225_CR12","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/cc11454","volume":"17","author":"JA Kellum","year":"2013","unstructured":"Kellum JA, Lameire N, Group KAGW. (2013) Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care 17(1):204. \n                    https:\/\/doi.org\/10.1186\/cc11454","journal-title":"Crit Care"},{"issue":"3","key":"2225_CR13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/ki.2012.429","volume":"83","author":"A Kodama","year":"2013","unstructured":"Kodama A, Watanabe H, Tanaka R et al (2013) A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy. Kidney Int 83(3):446\u201354. \n                    https:\/\/doi.org\/10.1038\/ki.2012.429","journal-title":"Kidney Int"},{"key":"2225_CR22","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1159\/000488827","volume":"46","author":"R Lei","year":"2018","unstructured":"Lei R, Zhao F, Tang C-Y et al (2018) Mitophagy plays a protective role in iodinated contrast-induced acute renal tubular epithelial cells injury. Cell Physiol Biochem 46(3):975\u2013985. \n                    https:\/\/doi.org\/10.1159\/000488827","journal-title":"Cell Physiol Biochem"},{"issue":"10","key":"2225_CR14","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1681\/ASN.2012121169","volume":"24","author":"A Linkermann","year":"2013","unstructured":"Linkermann A, Heller JO, Prokai A et al (2013) The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol 24(10):1545\u20131557. \n                    https:\/\/doi.org\/10.1681\/ASN.2012121169","journal-title":"J Am Soc Nephrol"},{"key":"2225_CR15","doi-asserted-by":"publisher","first-page":"427560","DOI":"10.1155\/2014\/427560","volume":"2014","author":"TQ Liu","year":"2014","unstructured":"Liu TQ, Luo WL, Tan X et al (2014) A novel contrast-induced acute kidney injury model based on the 5\/6-nephrectomy rat and nephrotoxicological evaluation of iohexol and iodixanol in vivo. Oxid Med Cell Longev 2014:427560. \n                    https:\/\/doi.org\/10.1155\/2014\/427560","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"2225_CR16","doi-asserted-by":"publisher","first-page":"7862","DOI":"10.1038\/s41598-017-08440-w","volume":"7","author":"M Luo","year":"2017","unstructured":"Luo M, Yang Y, Xu J et al (2017) A new scoring model for the prediction of mortality in patients with acute kidney injury. Sci Rep 7(1):7862. \n                    https:\/\/doi.org\/10.1038\/s41598-017-08440-w","journal-title":"Sci Rep"},{"issue":"12","key":"2225_CR17","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1007\/s00204-014-1401-9","volume":"89","author":"AR Nair","year":"2015","unstructured":"Nair AR, Lee WK, Smeets K et al (2015) Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney. Arch Toxicol 89(12):2273\u20132289. \n                    https:\/\/doi.org\/10.1007\/s00204-014-1401-9","journal-title":"Arch Toxicol"},{"issue":"3","key":"2225_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","volume":"12","author":"K Nakahira","year":"2011","unstructured":"Nakahira K, Haspel JA, Rathinam VA et al (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12(3):222\u201330. \n                    https:\/\/doi.org\/10.1038\/ni.1980","journal-title":"Nat Immunol"},{"issue":"6","key":"2225_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1159\/000337926","volume":"35","author":"G Ozkan","year":"2012","unstructured":"Ozkan G, Ulusoy S, Orem A et al (2012) Protective effect of the grape seed proanthocyanidin extract in a rat model of contrast-induced nephropathy. Kidney Blood Press Res 35(6):445\u201353. \n                    https:\/\/doi.org\/10.1159\/000337926","journal-title":"Kidney Blood Press Res"},{"issue":"1","key":"2225_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/019262338601400106","volume":"14","author":"LC Racusen","year":"1986","unstructured":"Racusen LC, Solez K (1986) Nephrotoxic tubular and interstitial lesions: morphology and classification. Toxicol Pathol 14(1):45\u201357. \n                    https:\/\/doi.org\/10.1177\/019262338601400106","journal-title":"Toxicol Pathol"},{"issue":"7","key":"2225_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jcin.2009.05.002","volume":"2","author":"M Reed","year":"2009","unstructured":"Reed M, Meier P, Tamhane UU, Welch KB, Moscucci M, Gurm HS (2009) The relative renal safety of iodixanol compared with low-osmolar contrast media: a meta-analysis of randomized controlled trials. JACC Cardiovasc Interv 2(7):645\u201354. \n                    https:\/\/doi.org\/10.1016\/j.jcin.2009.05.002","journal-title":"JACC Cardiovasc Interv"},{"key":"2225_CR23","doi-asserted-by":"publisher","first-page":"34682","DOI":"10.1038\/srep34682","volume":"6","author":"J Shen","year":"2016","unstructured":"Shen J, Wang L, Jiang N et al (2016) NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Sci Rep 6:34682. \n                    https:\/\/doi.org\/10.1038\/srep34682","journal-title":"Sci Rep"},{"key":"2225_CR24","doi-asserted-by":"publisher","first-page":"h4395","DOI":"10.1136\/bmj.h4395","volume":"351","author":"SA Silver","year":"2015","unstructured":"Silver SA, Shah PM, Chertow GM, Harel S, Wald R, Harel Z (2015) Risk prediction models for contrast induced nephropathy: systematic review. BMJ 351:h4395. \n                    https:\/\/doi.org\/10.1136\/bmj.h4395","journal-title":"BMJ"},{"issue":"4","key":"2225_CR25","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1097\/SLA.0b013e3182a4ea46","volume":"258","author":"JD Simmons","year":"2013","unstructured":"Simmons JD, Lee YL, Mulekar S et al (2013) Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. Ann Surg 258(4):591\u2013596. \n                    https:\/\/doi.org\/10.1097\/SLA.0b013e3182a4ea46\n                    \n                   (discussion 596\u20138)","journal-title":"Ann Surg"},{"issue":"1","key":"2225_CR26","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1016\/j.ijcard.2013.12.066","volume":"172","author":"S Sun","year":"2014","unstructured":"Sun S, Zhang T, Nie P et al (2014) A novel rat model of contrast-induced acute kidney injury. Int J Cardiol 172(1):e48\u201350. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2013.12.066","journal-title":"Int J Cardiol"},{"issue":"8","key":"2225_CR27","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1089\/ars.2010.3666","volume":"15","author":"D Tang","year":"2011","unstructured":"Tang D, Kang R, Livesey KM, Zeh HJ 3rd, Lotze MT (2011) High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. Antioxid Redox Signal 15(8):2185\u20132195. \n                    https:\/\/doi.org\/10.1089\/ars.2010.3666","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"2225_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000381510","volume":"1","author":"C Tang","year":"2015","unstructured":"Tang C, He L, Liu J, Dong Z (2015) Mitophagy: basic mechanism and potential role in kidney diseases. Kidney Dis (Basel) 1(1):71\u20139. \n                    https:\/\/doi.org\/10.1159\/000381510","journal-title":"Kidney Dis (Basel)"},{"key":"2225_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1405880","author":"C Tang","year":"2017","unstructured":"Tang C, Han H, Yan M et al. (2017) PINK1-PRKN\/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury. Autophagy. \n                    https:\/\/doi.org\/10.1080\/15548627.2017.1405880","journal-title":"Autophagy"},{"issue":"908","key":"2225_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1259\/bjr\/26964464","volume":"76","author":"HS Thomsen","year":"2003","unstructured":"Thomsen HS, Morcos SK (2003) Contrast media and the kidney: European Society of Urogenital Radiology (ESUR) guidelines. Br J Radiol 76(908):513\u2013518. \n                    https:\/\/doi.org\/10.1259\/bjr\/26964464","journal-title":"Br J Radiol"},{"issue":"7","key":"2225_CR31","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1681\/ASN.2015040376","volume":"27","author":"N Tsuji","year":"2016","unstructured":"Tsuji N, Tsuji T, Ohashi N, Kato A, Fujigaki Y, Yasuda H (2016) Role of mitochondrial DNA in septic AKI via toll-Like receptor 9. J Am Soc Nephrol 27(7):2009\u20132020. \n                    https:\/\/doi.org\/10.1681\/ASN.2015040376","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"2225_CR32","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1080\/15548627.2015.1063765","volume":"11","author":"K Unuma","year":"2015","unstructured":"Unuma K, Aki T, Funakoshi T, Hashimoto K, Uemura K (2015) Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: involvement of autophagy. Autophagy 11(9):1520\u20131536. \n                    https:\/\/doi.org\/10.1080\/15548627.2015.1063765","journal-title":"Autophagy"},{"key":"2225_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.ijcard.2016.01.004","volume":"206","author":"N Wang","year":"2016","unstructured":"Wang N, Qian P, Yan TD, Phan K (2016) Periprocedural effects of statins on the incidence of contrast-induced acute kidney injury: a systematic review and trial sequential analysis. Int J Cardiol 206:143\u201352. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2016.01.004","journal-title":"Int J Cardiol"},{"issue":"6","key":"2225_CR34","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1038\/ki.2015.240","volume":"88","author":"RM Whitaker","year":"2015","unstructured":"Whitaker RM, Stallons LJ, Kneff JE et al (2015) Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury. Kidney Int 88(6):1336\u20131344. \n                    https:\/\/doi.org\/10.1038\/ki.2015.240","journal-title":"Kidney Int"},{"key":"2225_CR35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","volume":"11","author":"L Xiao","year":"2017","unstructured":"Xiao L, Xu X, Zhang F et al (2017) The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1. Redox Biol 11:297\u2013311. \n                    https:\/\/doi.org\/10.1016\/j.redox.2016.12.022","journal-title":"Redox Biol"},{"issue":"2","key":"2225_CR36","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3892\/etm.2014.2132","volume":"9","author":"SK Yang","year":"2015","unstructured":"Yang SK, Duan SB, Pan P, Xu XQ, Liu N, Xu J (2015) Preventive effect of pentoxifylline on contrast-induced acute kidney injury in hypercholesterolemic rats. Exp Ther Med 9(2):384\u2013388. \n                    https:\/\/doi.org\/10.3892\/etm.2014.2132","journal-title":"Exp Ther Med"},{"issue":"2","key":"2225_CR37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s13318-011-0030-4","volume":"36","author":"L Zhuang","year":"2011","unstructured":"Zhuang L, Gao J, Zeng Y et al (2011) HPLC method validation for the quantification of lomustine to study pharmacokinetics of thermosensitive liposome-encapsulated lomustine containing iohexol for CT imaging in C6 glioma rats. Eur J Drug Metab Pharmacokinet 36(2):61\u20139. \n                    https:\/\/doi.org\/10.1007\/s13318-011-0030-4","journal-title":"Eur J Drug Metab Pharmacokinet"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-018-2225-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-018-2225-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-018-2225-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:54:12Z","timestamp":1559440452000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-018-2225-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,2]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2225"],"URL":"https:\/\/doi.org\/10.1007\/s00204-018-2225-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,2]]},"assertion":[{"value":"8 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}