{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:42:57Z","timestamp":1790383377655,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H30-kagaku-shitei-004"],"award-info":[{"award-number":["H30-kagaku-shitei-004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H25-kagaku-ippan-004"],"award-info":[{"award-number":["H25-kagaku-ippan-004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H28-kagaku-ippan 004"],"award-info":[{"award-number":["H28-kagaku-ippan 004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00204-019-02410-z","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T13:24:38Z","timestamp":1550064278000},"page":"909-920","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats"],"prefix":"10.1007","volume":"93","author":[{"given":"Mohamed","family":"Abdelgied","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"El-Gazzar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-3639","authenticated-orcid":false,"given":"David B.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Numano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Iigou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Naiki-Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Takase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Abbas","family":"Abdou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhji","family":"Taquahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"issue":"7","key":"2410_CR1","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1111\/cas.13643","volume":"109","author":"M Abdelgied","year":"2018","unstructured":"Abdelgied M, El-Gazzar AM, Alexander DB et al (2018) Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats. Cancer Sci 109(7):2164\u20132177. \n                    https:\/\/doi.org\/10.1111\/cas.13643","journal-title":"Cancer Sci"},{"issue":"2","key":"2410_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.2486\/indhealth.39.168","volume":"39","author":"S Adachi","year":"2001","unstructured":"Adachi S, Kawamura K, Takemoto K (2001) A trial on the quantitative risk assessment of man-made mineral fibers by the rat intraperitoneal administration assay using the JFM standard fibrous samples. Industrial Health 39(2):168\u2013174","journal-title":"Industrial Health"},{"key":"2410_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8977-11-18","volume":"11","author":"HM Braakhuis","year":"2014","unstructured":"Braakhuis HM, Park MV, Gosens I, De Jong WH, Cassee FR (2014) Physicochemical characteristics of nanomaterials that affect pulmonary inflammation. Part Fibre Toxicol 11:18. \n                    https:\/\/doi.org\/10.1186\/1743-8977-11-18","journal-title":"Part Fibre Toxicol"},{"issue":"6","key":"2410_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.2008.0027","volume":"29","author":"SL Deshmane","year":"2009","unstructured":"Deshmane SL, Kremlev S, Amini S, Sawaya BE (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 29(6):313\u2013326. \n                    https:\/\/doi.org\/10.1089\/jir.2008.0027","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"2410_CR5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2217\/nnm.10.139","volume":"6","author":"K Donaldson","year":"2011","unstructured":"Donaldson K, Murphy F, Schinwald A, Duffin R, Poland CA (2011) Identifying the pulmonary hazard of high aspect ratio nanoparticles to enable their safety-by-design. Nanomedicine (Lond) 6(1):143\u2013156. \n                    https:\/\/doi.org\/10.2217\/nnm.10.139","journal-title":"Nanomedicine (Lond)"},{"issue":"2","key":"2410_CR6","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1093\/toxsci\/kfi327","volume":"88","author":"A Elder","year":"2005","unstructured":"Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdorster G (2005) Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci 88(2):614\u2013629. \n                    https:\/\/doi.org\/10.1093\/toxsci\/kfi327","journal-title":"Toxicol Sci"},{"key":"2410_CR7","first-page":"1","volume":"5","author":"AM El-Gazzar","year":"2018","unstructured":"El-Gazzar AM, Abdelgied M, Alexander DB et al (2018) Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. Arch Toxicol 5:1\u201311","journal-title":"Arch Toxicol"},{"issue":"4731","key":"2410_CR8","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1126\/science.4071052","volume":"230","author":"AG Harmsen","year":"1985","unstructured":"Harmsen AG, Muggenburg BA, Snipes MB, Bice DE (1985) The role of macrophages in particle translocation from lungs to lymph nodes. Science 230(4731):1277\u20131280","journal-title":"Science"},{"issue":"1","key":"2410_CR9","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.canlet.2006.12.012","volume":"252","author":"B Huang","year":"2007","unstructured":"Huang B, Lei Z, Zhao J et al (2007) CCL2\/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett 252(1):86\u201392. \n                    https:\/\/doi.org\/10.1016\/j.canlet.2006.12.012","journal-title":"Cancer Lett"},{"issue":"5","key":"2410_CR10","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/08958370490428391","volume":"16","author":"T Ikegami","year":"2004","unstructured":"Ikegami T, Tanaka A, Taniguchi M et al (2004) Chronic inhalation toxicity and carcinogenicity study on potassium octatitanate fibers (TISMO) in rats. Inhal Toxicol 16(5):291\u2013310. \n                    https:\/\/doi.org\/10.1080\/08958370490428391","journal-title":"Inhal Toxicol"},{"issue":"1","key":"2410_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12989-016-0164-2","volume":"13","author":"T Kasai","year":"2016","unstructured":"Kasai T, Umeda Y, Ohnishi M et al (2016) Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats. Part Fibre Toxicol 13(1):53. \n                    https:\/\/doi.org\/10.1186\/s12989-016-0164-2","journal-title":"Part Fibre Toxicol"},{"issue":"7","key":"2410_CR12","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1084\/jem.20141836","volume":"212","author":"T Kitamura","year":"2015","unstructured":"Kitamura T, Qian BZ, Soong D et al (2015) CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 212(7):1043\u20131059. \n                    https:\/\/doi.org\/10.1084\/jem.20141836","journal-title":"J Exp Med"},{"issue":"3","key":"2410_CR13","first-page":"314","volume":"102","author":"KP Lee","year":"1981","unstructured":"Lee KP, Barras CE, Griffith FD, Waritz RS (1981) Pulmonary response and transmigration of inorganic fibers by inhalation exposure. Am J Pathol 102(3):314\u2013323","journal-title":"Am J Pathol"},{"issue":"4","key":"2410_CR14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402\u2013408. \n                    https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"2410_CR15","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1476-069X-7-4","volume":"7","author":"G Miserocchi","year":"2008","unstructured":"Miserocchi G, Sancini G, Mantegazza F, Chiappino G (2008) Translocation pathways for inhaled asbestos fibers. Environ Health 7:4. \n                    https:\/\/doi.org\/10.1186\/1476-069X-7-4","journal-title":"Environ Health"},{"key":"2410_CR16","unstructured":"NIOSH (2011) Current intelligence bulletin 62. Asbestos fibers and other elongate mineral particles: state of the science and road map for research. 2011. \n                    https:\/\/www.cdc.gov\/niosh\/docs\/2011-159\/pdfs\/2011-159.pdf\n                    \n                   Accessed 24 Oct 2017"},{"issue":"5","key":"2410_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1539\/joh.46.382","volume":"46","author":"T Oyabu","year":"2004","unstructured":"Oyabu T, Yamato H, Ogami A et al (2004) The effect of lung burden on biopersistence and pulmonary effects in rats exposed to potassium octatitanate whiskers by inhalation. J Occup Health 46(5):382\u2013390","journal-title":"J Occup Health"},{"key":"2410_CR18","doi-asserted-by":"publisher","first-page":"282739","DOI":"10.1155\/2011\/282739","volume":"2011","author":"I Perrotta","year":"2011","unstructured":"Perrotta I, Carito V, Russo E, Tripepi S, Aquila S, Donato G (2011) Macrophage autophagy and oxidative stress: an ultrastructural and immunoelectron microscopical study. Oxid Med Cell Longev 2011:282739. \n                    https:\/\/doi.org\/10.1155\/2011\/282739","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"2410_CR19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood.V96.1.34","volume":"96","author":"R Salcedo","year":"2000","unstructured":"Salcedo R, Ponce ML, Young HA et al (2000) Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 96(1):34\u201340","journal-title":"Blood"},{"issue":"5","key":"2410_CR20","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1189\/jlb.0609385","volume":"86","author":"G Solinas","year":"2009","unstructured":"Solinas G, Germano G, Mantovani A, Allavena P (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86(5):1065\u20131073. \n                    https:\/\/doi.org\/10.1189\/jlb.0609385","journal-title":"J Leukoc Biol"},{"key":"2410_CR21","unstructured":"Stanton MF, Layard M (1978) The carcinogenicity of fibrous minerals. In: workshop on asbestos: definitions and measurement methods. National Bureau of Standards Special Publication. \n                    https:\/\/ia801405.us.archive.org\/6\/items\/proceedingsofwor506grav\/proceedingsofwor506grav.pdf\n                    \n                   Accessed 08 Dec 2018. 506:143\u2013151"},{"issue":"5","key":"2410_CR22","first-page":"965","volume":"67","author":"MF Stanton","year":"1981","unstructured":"Stanton MF, Layard M, Tegeris A et al (1981) Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst 67(5):965\u2013975","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"2410_CR23","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/cas.12954","volume":"107","author":"M Suzui","year":"2016","unstructured":"Suzui M, Futakuchi M, Fukamachi K et al (2016) Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignant mesothelioma and lung tumors. Cancer Sci 107(7):924\u2013935. \n                    https:\/\/doi.org\/10.1111\/cas.12954","journal-title":"Cancer Sci"},{"issue":"4","key":"2410_CR24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.2131\/jts.38.619","volume":"38","author":"Y Taquahashi","year":"2013","unstructured":"Taquahashi Y, Ogawa Y, Takagi A, Tsuji M, Morita K, Kanno J (2013) Improved dispersion method of multi-wall carbon nanotube for inhalation toxicity studies of experimental animals. J Toxicol Sci 38(4):619\u2013628","journal-title":"J Toxicol Sci"},{"key":"2410_CR25","unstructured":"WHO (2005) Workshop on Mechanisms of fibre carcinogenesis and assessment of chrysotile asbestos substitutes 8\u201312 November 2005, Lyon, France. Summary Consensus Report. \n                    https:\/\/www.who.int\/ipcs\/publications\/new_issues\/summary_report.pdf\n                    \n                   Accessed 22 Oct 2018"},{"issue":"9","key":"2410_CR26","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.4049\/jimmunol.181.9.6384","volume":"181","author":"Y Wu","year":"2008","unstructured":"Wu Y, Li YY, Matsushima K, Baba T, Mukaida N (2008) CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J Immunol 181(9):6384\u20136393","journal-title":"J Immunol"},{"issue":"12","key":"2410_CR27","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1111\/cas.12005","volume":"103","author":"J Xu","year":"2012","unstructured":"Xu J, Futakuchi M, Shimizu H et al (2012) Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats. Cancer Sci 103(12):2045\u20132050. \n                    https:\/\/doi.org\/10.1111\/cas.12005","journal-title":"Cancer Sci"},{"issue":"1","key":"2410_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1539\/joh.44.34","volume":"44","author":"H Yamato","year":"2002","unstructured":"Yamato H, Morimoto Y, Tsuda T et al (2002) Clearance of inhaled potassium octatitanate whisker from rat lungs. J Occupat Health 44(1):34\u201339","journal-title":"J Occupat Health"},{"issue":"14","key":"2410_CR29","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1080\/08958370390248969","volume":"15","author":"H Yamato","year":"2003","unstructured":"Yamato H, Oyabu T, Ogami A et al (2003) Pulmonary effects and clearance after long-term inhalation of potassium octatitanate whiskers in rats. Inhal Toxicol 15(14):1421\u20131434. \n                    https:\/\/doi.org\/10.1080\/08958370390248969","journal-title":"Inhal Toxicol"},{"key":"2410_CR30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cyto.2017.02.001","volume":"98","author":"T Yoshimura","year":"2017","unstructured":"Yoshimura T (2017) The production of monocyte chemoattractant protein-1 (MCP-1)\/CCL2 in tumor microenvironments. Cytokine 98:71\u201378. \n                    https:\/\/doi.org\/10.1016\/j.cyto.2017.02.001","journal-title":"Cytokine"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-019-02410-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02410-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02410-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T19:07:32Z","timestamp":1581534452000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-019-02410-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["2410"],"URL":"https:\/\/doi.org\/10.1007\/s00204-019-02410-z","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]},"assertion":[{"value":"15 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Horiyuki Tsuda received 3,000,000 JPY from YOG Specified Nonprofit Corporation. There are no other potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}