{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:06:33Z","timestamp":1782187593467,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670724"],"award-info":[{"award-number":["81670724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00204-019-02458-x","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T16:05:01Z","timestamp":1556121901000},"page":"1639-1648","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["2,3\u2032,4,4\u2032,5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2\/PKD\/VPS34 pathway"],"prefix":"10.1007","volume":"93","author":[{"given":"Qi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlu","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"2458_CR1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1530\/eje.1.02128","volume":"154","author":"M Boas","year":"2006","unstructured":"Boas M, Feldt-Rasmussen U, Skakkebaek NE, Main KM (2006) Environmental chemicals and thyroid function. Eur J Endocrinol 154:599\u2013611. https:\/\/doi.org\/10.1530\/eje.1.02128","journal-title":"Eur J Endocrinol"},{"key":"2458_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41392-018-0018-5","volume":"3","author":"Q Chen","year":"2018","unstructured":"Chen Q, Kang J, Fu C (2018) The independence of and associations among apoptosis, autophagy, and necrosis. Signal Transduct Target Ther 3:18. https:\/\/doi.org\/10.1038\/s41392-018-0018-5","journal-title":"Signal Transduct Target Ther"},{"key":"2458_CR3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15833","author":"M Chuang","year":"2016","unstructured":"Chuang M, Hsiao TI, Tong A, Xu S, Chisholm AD (2016) DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair. eLife. https:\/\/doi.org\/10.7554\/eLife.15833","journal-title":"eLife"},{"key":"2458_CR4","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/sj.cdd.4402212","volume":"14","author":"A Eisenberg-Lerner","year":"2007","unstructured":"Eisenberg-Lerner A, Kimchi A (2007) DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress. Cell Death Differ 14:1908\u20131915. https:\/\/doi.org\/10.1038\/sj.cdd.4402212","journal-title":"Cell Death Differ"},{"key":"2458_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ceb.2009.11.008","volume":"22","author":"S Etienne-Manneville","year":"2010","unstructured":"Etienne-Manneville S (2010) From signaling pathways to microtubule dynamics: the key players. Curr Opin Cell Biol 22:104\u2013111. https:\/\/doi.org\/10.1016\/j.ceb.2009.11.008","journal-title":"Curr Opin Cell Biol"},{"key":"2458_CR6","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1080\/19440049.2011.553844","volume":"28","author":"M Feinberg","year":"2011","unstructured":"Feinberg M, Soler L, Contenot S, Verger P (2011) Assessment of seasonality in exposure to dioxins, fursans and dioxin-like PCBs by using long-term food-consumption data food additives and contaminants Part A. Chem Anal Control Expo Risk Assess 28:502\u2013512. https:\/\/doi.org\/10.1080\/19440049.2011.553844","journal-title":"Chem Anal Control Expo Risk Assess"},{"key":"2458_CR7","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1210\/en.2010-1490","volume":"152","author":"S Giera","year":"2011","unstructured":"Giera S, Bansal R, Ortiz-Toro TM, Taub DG, Zoeller RT (2011) Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development. Endocrinology 152:2909\u20132919. https:\/\/doi.org\/10.1210\/en.2010-1490","journal-title":"Endocrinology"},{"key":"2458_CR8","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1002\/jat.3032","volume":"35","author":"H Guo","year":"2015","unstructured":"Guo H et al (2015) Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt\/FoxO3a\/NIS pathway. J Appl Toxicol: JAT 35:992\u2013998. https:\/\/doi.org\/10.1002\/jat.3032","journal-title":"J Appl Toxicol: JAT"},{"key":"2458_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","volume":"43","author":"C He","year":"2009","unstructured":"He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Ann Rev Genet 43:67\u201393. https:\/\/doi.org\/10.1146\/annurev-genet-102808-114910","journal-title":"Ann Rev Genet"},{"key":"2458_CR10","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s10661-015-4466-x","volume":"187","author":"J Huang","year":"2015","unstructured":"Huang J, Amuzu-Sefordzi B, Li M (2015) Heavy metals and polychlorinated biphenyls (PCBs) sedimentation in the Lianhua Mountain Reservoir, Pearl River Delta. China Environ Monit Assess 187:254. https:\/\/doi.org\/10.1007\/s10661-015-4466-x","journal-title":"China Environ Monit Assess"},{"key":"2458_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbrc.2015.10.151","volume":"468","author":"K Isshiki","year":"2015","unstructured":"Isshiki K, Hirase T, Matsuda S, Miyamoto K, Tsuji A, Yuasa K (2015) Death-associated protein kinase 2 mediates nocodazole-induced apoptosis through interaction with tubulin. Biochem Biophys Res Commun 468:113\u2013118. https:\/\/doi.org\/10.1016\/j.bbrc.2015.10.151","journal-title":"Biochem Biophys Res Commun"},{"key":"2458_CR12","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10495-013-0916-5","volume":"19","author":"J Ivanovska","year":"2014","unstructured":"Ivanovska J, Mahadevan V, Schneider-Stock R (2014) DAPK and cytoskeleton-associated functions. Apoptosis: Int J Program Cell Death 19:329\u2013338. https:\/\/doi.org\/10.1007\/s10495-013-0916-5","journal-title":"Apoptosis: Int J Program Cell Death"},{"key":"2458_CR13","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.chemosphere.2008.07.087","volume":"73","author":"JH Kang","year":"2008","unstructured":"Kang JH, Park H, Chang YS, Choi JW (2008) Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in human serum from urban areas in Korea. Chemosphere 73:1625\u20131631. https:\/\/doi.org\/10.1016\/j.chemosphere.2008.07.087","journal-title":"Chemosphere"},{"key":"2458_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.5094\/Apr.2012.050","volume":"3","author":"E Kaya","year":"2012","unstructured":"Kaya E, Dumanoglu Y, Kara M, Altiok H, Bayram A, Elbir T, Odabasi M (2012) Spatial and temporal variation and air-soil exchange of atmospheric PAHs and PCBs in an industrial region Atmos Pollut Res 3:435\u2013449. https:\/\/doi.org\/10.5094\/Apr.2012.050","journal-title":"Spatial and temporal variation and air-soil exchange of atmospheric PAHs and PCBs in an industrial region Atmos Pollut Res"},{"key":"2458_CR15","doi-asserted-by":"publisher","first-page":"e0125213","DOI":"10.1371\/journal.pone.0125213","volume":"10","author":"S Kim","year":"2015","unstructured":"Kim S et al (2015) Association between several persistent organic pollutants and thyroid hormone levels in cord blood serum and bloodspot of the newborn infants of Korea. PLoS ONE 10:e0125213. https:\/\/doi.org\/10.1371\/journal.pone.0125213","journal-title":"PLoS ONE"},{"key":"2458_CR16","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/10408440600845304","volume":"36","author":"S Knerr","year":"2006","unstructured":"Knerr S, Schrenk D (2006) Carcinogenicity of \"non-dioxinlike\" polychlorinated biphenyls. Crit Rev Toxicol 36:663\u2013694. https:\/\/doi.org\/10.1080\/10408440600845304","journal-title":"Crit Rev Toxicol"},{"issue":"Suppl 2","key":"2458_CR17","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/sj.cdd.4401724","volume":"12","author":"G Kroemer","year":"2005","unstructured":"Kroemer G et al (2005) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death. Cell Death Differ 12(Suppl 2):1463\u20131467. https:\/\/doi.org\/10.1038\/sj.cdd.4401724","journal-title":"Cell Death Differ"},{"key":"2458_CR18","first-page":"13","volume":"39","author":"P Langer","year":"2005","unstructured":"Langer P et al (2005) Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades. Endocr Regul 39:13\u201320","journal-title":"Endocr Regul"},{"key":"2458_CR19","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s10495-013-0918-3","volume":"19","author":"V Levin-Salomon","year":"2014","unstructured":"Levin-Salomon V, Bialik S, Kimchi A (2014) DAP-kinase and autophagy. Apoptosis Int J Program Cell Death 19:346\u2013356. https:\/\/doi.org\/10.1007\/s10495-013-0918-3","journal-title":"Apoptosis Int J Program Cell Death"},{"key":"2458_CR20","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394\u0394C(T)) method. Methods (San Diego, Calif) 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods (San Diego, Calif)"},{"key":"2458_CR21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1158\/0008-5472.Can-14-2740ss","volume":"75","author":"JA McCarroll","year":"2015","unstructured":"McCarroll JA et al (2015) TUBB3\/betaIII-tubulin acts through the PTEN\/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer. Cancer Res 75:415\u2013425. https:\/\/doi.org\/10.1158\/0008-5472.Can-14-2740ss","journal-title":"Cancer Res"},{"key":"2458_CR22","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/erc-13-0271","volume":"21","author":"F Morani","year":"2014","unstructured":"Morani F, Titone R, Pagano L, Galetto A, Alabiso O, Aimaretti G, Isidoro C (2014) Autophagy and thyroid carcinogenesis: genetic and epigenetic links. Endocr Relat Cancer 21:R13\u201329. https:\/\/doi.org\/10.1530\/erc-13-0271","journal-title":"Endocr Relat Cancer"},{"key":"2458_CR23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.33549\/physiolres.931022","volume":"56","author":"D Mullerova","year":"2007","unstructured":"Mullerova D, Kopecky J (2007) White adipose tissue: storage and effector site for environmental pollutants. Physiol Res 56:375\u2013381","journal-title":"Physiol Res"},{"key":"2458_CR24","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.tiv.2013.02.012","volume":"27","author":"AJ Murk","year":"2013","unstructured":"Murk AJ et al (2013) Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicol Int J Publ Assoc BIBRA 27:1320\u20131346. https:\/\/doi.org\/10.1016\/j.tiv.2013.02.012","journal-title":"Toxicol Int J Publ Assoc BIBRA"},{"key":"2458_CR25","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.envint.2011.07.006","volume":"40","author":"CVC Rudge","year":"2012","unstructured":"Rudge CVC et al (2012) Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of Sao Paulo State. Brazil Environ Ints 40:162\u2013169. https:\/\/doi.org\/10.1016\/j.envint.2011.07.006","journal-title":"Brazil Environ Ints"},{"key":"2458_CR26","doi-asserted-by":"publisher","first-page":"888","DOI":"10.7589\/0090-3558-44.4.888","volume":"44","author":"JG Schnitzler","year":"2008","unstructured":"Schnitzler JG, Siebert U, Jepson PD, Beineke A, Jauniaux T, Bouquegneau JM, Das K (2008) Harbor porpoise thyroids: histologic investigations and potential interactions with environmental factors. J Wildl Dis 44:888\u2013901. https:\/\/doi.org\/10.7589\/0090-3558-44.4.888","journal-title":"J Wildl Dis"},{"key":"2458_CR27","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s10495-013-0924-5","volume":"19","author":"R Shiloh","year":"2014","unstructured":"Shiloh R, Bialik S, Kimchi A (2014) The DAPK family: a structure-function analysis. Apoptosis Int J Program Cell Death 19:286\u2013297. https:\/\/doi.org\/10.1007\/s10495-013-0924-5","journal-title":"Apoptosis Int J Program Cell Death"},{"key":"2458_CR28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fnmol.2016.00046","volume":"9","author":"P Singh","year":"2016","unstructured":"Singh P, Ravanan P, Talwar P (2016) Death associated protein kinase 1 (DAPK1): a regulator of apoptosis and autophagy. Front Mol Neurosci 9:46. https:\/\/doi.org\/10.3389\/fnmol.2016.00046","journal-title":"Front Mol Neurosci"},{"key":"2458_CR29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1289\/ehp.8661","volume":"114","author":"M Tabuchi","year":"2006","unstructured":"Tabuchi M, Veldhoen N, Dangerfield N, Jeffries S, Helbing CC, Ross PS (2006) PCB-related alteration of thyroid hormones and thyroid hormone receptor gene expression in free-ranging harbor seals (Phoca vitulina). Environ Health Perspect 114:1024\u20131031. https:\/\/doi.org\/10.1289\/ehp.8661","journal-title":"Environ Health Perspect"},{"key":"2458_CR30","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.etp.2013.02.001","volume":"65","author":"JM Tang","year":"2013","unstructured":"Tang JM et al (2013) Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp Toxicol Pathol 65:989\u2013994. https:\/\/doi.org\/10.1016\/j.etp.2013.02.001","journal-title":"Exp Toxicol Pathol"},{"key":"2458_CR31","first-page":"517","volume":"19","author":"HA Tilson","year":"1998","unstructured":"Tilson HA, Kodavanti PR (1998) The neurotoxicity of polychlorinated biphenyls. Neurotoxicology 19:517\u2013525","journal-title":"Neurotoxicology"},{"key":"2458_CR32","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1042\/BSR20100025","volume":"30","author":"MA Tischfield","year":"2010","unstructured":"Tischfield MA, Engle EC (2010) Distinct alpha- and beta-tubulin isotypes are required for the positioning, differentiation and survival of neurons: new support for the 'multi-tubulin' hypothesis. Biosci Rep 30:319\u2013330. https:\/\/doi.org\/10.1042\/BSR20100025","journal-title":"Biosci Rep"},{"key":"2458_CR33","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.jaut.2016.07.008","volume":"75","author":"C Xu","year":"2016","unstructured":"Xu C et al (2016b) Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease. J Autoimmun 75:50\u201357. https:\/\/doi.org\/10.1016\/j.jaut.2016.07.008","journal-title":"J Autoimmun"},{"key":"2458_CR34","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/toxsci\/kfv235","volume":"149","author":"B Xu","year":"2016","unstructured":"Xu B et al (2016a) 2,3',4,4',5-Pentachlorobiphenyl induces inflammatory responses in the thyroid through jnk and aryl hydrocarbon receptor-mediated pathway. Toxicol Sci 149:300\u2013311. https:\/\/doi.org\/10.1093\/toxsci\/kfv235","journal-title":"Toxicol Sci"},{"key":"2458_CR35","doi-asserted-by":"publisher","first-page":"e0120133","DOI":"10.1371\/journal.pone.0120133","volume":"10","author":"H Yang","year":"2015","unstructured":"Yang H et al (2015) Molecular mechanisms of 2, 3', 4, 4', 5-pentachlorobiphenyl-induced thyroid dysfunction in FRTL-5 cells. PLoS ONE 10:e0120133. https:\/\/doi.org\/10.1371\/journal.pone.0120133","journal-title":"PLoS ONE"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02458-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-019-02458-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02458-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T19:55:49Z","timestamp":1663358149000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-019-02458-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["2458"],"URL":"https:\/\/doi.org\/10.1007\/s00204-019-02458-x","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]},"assertion":[{"value":"18 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All rats used in the experiment were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflicts of interest concerning this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}