{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T02:57:27Z","timestamp":1782615447737,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002858","name":"Postdoctoral Science Foundation of China","doi-asserted-by":"crossref","award":["2016M600199"],"award-info":[{"award-number":["2016M600199"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773405"],"award-info":[{"award-number":["81773405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Outstanding Youth Science Foundation of Shanxi Province","award":["201701D211008"],"award-info":[{"award-number":["201701D211008"]}]},{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["2017-058"],"award-info":[{"award-number":["2017-058"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the PhD Start-up Fund of Shanxi Medical University","award":["BS03201647"],"award-info":[{"award-number":["BS03201647"]}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["ES022629"],"award-info":[{"award-number":["ES022629"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00204-019-02651-y","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T20:03:41Z","timestamp":1576526621000},"page":"749-760","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring"],"prefix":"10.1007","volume":"94","author":[{"given":"Xiaolin","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xushen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-3670","authenticated-orcid":false,"given":"Xiaoyan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"issue":"11","key":"2651_CR1","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1007\/s00204-018-2311-z","volume":"92","author":"HM Bolt","year":"2018","unstructured":"Bolt HM, Hengstler JG (2018) Contemporary trends in toxicological research on arsenic. Arch Toxicol 92(11):3251\u20133253. https:\/\/doi.org\/10.1007\/s00204-018-2311-z","journal-title":"Arch Toxicol"},{"key":"2651_CR2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.chemosphere.2013.11.035","volume":"100","author":"KD Brahman","year":"2014","unstructured":"Brahman KD, Kazi TG, Baig JA, Afridi HI, Khan A, Arain SS, Arain MB (2014) Fluoride and arsenic exposure through water and grain crops in Nagarparkar, Pakistan. Chemosphere 100:182\u2013189. https:\/\/doi.org\/10.1016\/j.chemosphere.2013.11.035","journal-title":"Chemosphere"},{"issue":"12","key":"2651_CR3","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.7150\/ijbs.27774","volume":"14","author":"X Cai","year":"2018","unstructured":"Cai X, She M, Xu M, Chen H, Li J, Chen X, Zheng D, Liu J, Chen S, Zhu J, Xu X, Li R, Li J, Chen S, Yang X, Li H (2018) GLP-1 treatment protects endothelial cells from oxidative stress-induced autophagy and endothelial dysfunction. Int J Biol Sci 14(12):1696\u20131708. https:\/\/doi.org\/10.7150\/ijbs.27774","journal-title":"Int J Biol Sci"},{"key":"2651_CR4","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.envres.2016.06.032","volume":"150","author":"M Cardenas-Gonzalez","year":"2016","unstructured":"Cardenas-Gonzalez M, Osorio-Yanez C, Gaspar-Ramirez O, Pavkovic M, Ochoa-Martinez A, Lopez-Ventura D, Medeiros M, Barbier OC, Perez-Maldonado IN, Sabbisetti VS, Bonventre JV, Vaidya VS (2016) Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1. Environ Res 150:653\u2013662. https:\/\/doi.org\/10.1016\/j.envres.2016.06.032","journal-title":"Environ Res"},{"key":"2651_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jtemb.2016.05.001","volume":"38","author":"D Chakraborti","year":"2016","unstructured":"Chakraborti D, Rahman MM, Chatterjee A, Das D, Das B, Nayak B, Pal A, Chowdhury UK, Ahmed S, Biswas BK, Sengupta MK, Lodh D, Samanta G, Chakraborty S, Roy MM, Dutta RN, Saha KC, Mukherjee SC, Pati S, Kar PB (2016) Fate of over 480 million inhabitants living in arsenic and fluoride endemic Indian districts: magnitude, health, socio-economic effects and mitigation approaches. J Trace Elem Med Biol Organ Soc Miner Trace Elem (GMS) 38:33\u201345. https:\/\/doi.org\/10.1016\/j.jtemb.2016.05.001","journal-title":"J Trace Elem Med Biol Organ Soc Miner Trace Elem (GMS)"},{"issue":"4","key":"2651_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s00204-010-0588-7","volume":"85","author":"A Chattopadhyay","year":"2011","unstructured":"Chattopadhyay A, Podder S, Agarwal S, Bhattacharya S (2011) Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice. Arch Toxicol 85(4):327\u2013335. https:\/\/doi.org\/10.1007\/s00204-010-0588-7","journal-title":"Arch Toxicol"},{"key":"2651_CR7","doi-asserted-by":"publisher","first-page":"d2431","DOI":"10.1136\/bmj.d2431","volume":"342","author":"Y Chen","year":"2011","unstructured":"Chen Y, Graziano JH, Parvez F, Liu M, Slavkovich V, Kalra T, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, van Geen A, Ahsan H (2011) Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. BMJ (Clinical research ed) 342:d2431. https:\/\/doi.org\/10.1136\/bmj.d2431","journal-title":"BMJ (Clinical research ed)"},{"key":"2651_CR8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.jhazmat.2016.09.032","volume":"321","author":"YY Cheng","year":"2017","unstructured":"Cheng YY, Huang NC, Chang YT, Sung JM, Shen KH, Tsai CC, Guo HR (2017a) Associations between arsenic in drinking water and the progression of chronic kidney disease: a nationwide study in Taiwan. J Hazard Mater 321:432\u2013439. https:\/\/doi.org\/10.1016\/j.jhazmat.2016.09.032","journal-title":"J Hazard Mater"},{"issue":"6","key":"2651_CR9","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1074\/jbc.M116.758268","volume":"292","author":"Z Cheng","year":"2017","unstructured":"Cheng Z, Zhu Q, Dee R, Opheim Z, Mack CP, Cyr DM, Taylor JM (2017b) Focal adhesion kinase-mediated phosphorylation of Beclin1 protein suppresses cardiomyocyte autophagy and initiates hypertrophic growth. J Biol Chem 292(6):2065\u20132079. https:\/\/doi.org\/10.1074\/jbc.M116.758268","journal-title":"J Biol Chem"},{"issue":"3","key":"2651_CR10","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3390\/cells1030597","volume":"1","author":"R Chiarelli","year":"2012","unstructured":"Chiarelli R, Roccheri MC (2012) Heavy metals and metalloids as autophagy inducing agents: focus on cadmium and arsenic. Cells 1(3):597\u2013616. https:\/\/doi.org\/10.3390\/cells1030597","journal-title":"Cells"},{"key":"2651_CR11","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jinorgbio.2018.02.015","volume":"182","author":"BX Chu","year":"2018","unstructured":"Chu BX, Fan RF, Lin SQ, Yang DB, Wang ZY, Wang L (2018) Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells. J Inorg Biochem 182:184\u2013193. https:\/\/doi.org\/10.1016\/j.jinorgbio.2018.02.015","journal-title":"J Inorg Biochem"},{"key":"2651_CR12","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chemosphere.2017.12.021","volume":"194","author":"N Das","year":"2018","unstructured":"Das N, Das A, Sarma KP, Kumar M (2018) Provenance, prevalence and health perspective of co-occurrences of arsenic, fluoride and uranium in the aquifers of the Brahmaputra River floodplain. Chemosphere 194:755\u2013772. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.12.021","journal-title":"Chemosphere"},{"issue":"3","key":"2651_CR13","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/0960327118814161","volume":"38","author":"RW Dharmaratne","year":"2019","unstructured":"Dharmaratne RW (2019) Exploring the role of excess fluoride in chronic kidney disease: a review. Hum Exp Toxicol 38(3):269\u2013279. https:\/\/doi.org\/10.1177\/0960327118814161","journal-title":"Hum Exp Toxicol"},{"issue":"11","key":"2651_CR14","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1007\/s00204-014-1408-2","volume":"89","author":"YT Dong","year":"2015","unstructured":"Dong YT, Wang Y, Wei N, Zhang QF, Guan ZZ (2015) Deficit in learning and memory of rats with chronic fluorosis correlates with the decreased expressions of M1 and M3 muscarinic acetylcholine receptors. Arch Toxicol 89(11):1981\u20131991. https:\/\/doi.org\/10.1007\/s00204-014-1408-2","journal-title":"Arch Toxicol"},{"key":"2651_CR15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.envres.2016.11.008","volume":"153","author":"AS Ettinger","year":"2017","unstructured":"Ettinger AS, Arbuckle TE, Fisher M, Liang CL, Davis K, Cirtiu CM, Belanger P, LeBlanc A, Fraser WD (2017) Arsenic levels among pregnant women and newborns in Canada: results from the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort. Environ Res 153:8\u201316. https:\/\/doi.org\/10.1016\/j.envres.2016.11.008","journal-title":"Environ Res"},{"issue":"4","key":"2651_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10534-011-9412-y","volume":"24","author":"SJ Flora","year":"2011","unstructured":"Flora SJ, Pachauri V, Mittal M, Kumar D (2011) Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species. Biomet Int J Role Metal Ions Biol Biochem Med 24(4):615\u2013628. https:\/\/doi.org\/10.1007\/s10534-011-9412-y","journal-title":"Biomet Int J Role Metal Ions Biol Biochem Med"},{"issue":"8","key":"2651_CR17","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1007\/s00204-018-2239-3","volume":"92","author":"AR Gliga","year":"2018","unstructured":"Gliga AR, Engstrom K, Kippler M, Skroder H, Ahmed S, Vahter M, Raqib R, Broberg K (2018) Prenatal arsenic exposure is associated with increased plasma IGFBP3 concentrations in 9-year-old children partly via changes in DNA methylation. Arch Toxicol 92(8):2487\u20132500. https:\/\/doi.org\/10.1007\/s00204-018-2239-3","journal-title":"Arch Toxicol"},{"key":"2651_CR18","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jinorgbio.2018.12.008","volume":"192","author":"ZG Gong","year":"2019","unstructured":"Gong ZG, Wang XY, Wang JH, Fan RF, Wang L (2019) Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis. J Inorg Biochem 192:62\u201371. https:\/\/doi.org\/10.1016\/j.jinorgbio.2018.12.008","journal-title":"J Inorg Biochem"},{"issue":"5","key":"2651_CR19","doi-asserted-by":"publisher","first-page":"4587","DOI":"10.3390\/ijerph120504587","volume":"12","author":"C Gonzalez-Horta","year":"2015","unstructured":"Gonzalez-Horta C, Ballinas-Casarrubias L, Sanchez-Ramirez B, Ishida MC, Barrera-Hernandez A, Gutierrez-Torres D, Zacarias OL, Saunders RJ, Drobna Z, Mendez MA, Garcia-Vargas G, Loomis D, Styblo M, Del Razo LM (2015) A concurrent exposure to arsenic and fluoride from drinking water in Chihuahua, Mexico. Int J Environ Res Public Health 12(5):4587\u20134601. https:\/\/doi.org\/10.3390\/ijerph120504587","journal-title":"Int J Environ Res Public Health"},{"issue":"3","key":"2651_CR20","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.semnephrol.2016.03.005","volume":"36","author":"A Havasi","year":"2016","unstructured":"Havasi A, Dong Z (2016) Autophagy and tubular cell death in the kidney. Semin Nephrol 36(3):174\u2013188. https:\/\/doi.org\/10.1016\/j.semnephrol.2016.03.005","journal-title":"Semin Nephrol"},{"issue":"4","key":"2651_CR21","doi-asserted-by":"publisher","first-page":"e96041","DOI":"10.1371\/journal.pone.0096041","volume":"9","author":"S Jiang","year":"2014","unstructured":"Jiang S, Su J, Yao S, Zhang Y, Cao F, Wang F, Wang H, Li J, Xi S (2014) Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats. PLoS ONE 9(4):e96041. https:\/\/doi.org\/10.1371\/journal.pone.0096041","journal-title":"PLoS ONE"},{"key":"2651_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.taap.2018.05.027","volume":"352","author":"MI Jimenez-Cordova","year":"2018","unstructured":"Jimenez-Cordova MI, Cardenas-Gonzalez M, Aguilar-Madrid G, Sanchez-Pena LC, Barrera-Hernandez A, Dominguez-Guerrero IA, Gonzalez-Horta C, Barbier OC, Del Razo LM (2018) Evaluation of kidney injury biomarkers in an adult Mexican population environmentally exposed to fluoride and low arsenic levels. Toxicol Appl Pharmacol 352:97\u2013106. https:\/\/doi.org\/10.1016\/j.taap.2018.05.027","journal-title":"Toxicol Appl Pharmacol"},{"issue":"5","key":"2651_CR23","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.neuro.2012.07.003","volume":"33","author":"J Jing","year":"2012","unstructured":"Jing J, Zheng G, Liu M, Shen X, Zhao F, Wang J, Zhang J, Huang G, Dai P, Chen Y, Chen J, Luo W (2012) Changes in the synaptic structure of hippocampal neurons and impairment of spatial memory in a rat model caused by chronic arsenite exposure. Neurotoxicology 33(5):1230\u20131238. https:\/\/doi.org\/10.1016\/j.neuro.2012.07.003","journal-title":"Neurotoxicology"},{"issue":"11","key":"2651_CR24","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s10661-017-6288-5","volume":"189","author":"AL Khandare","year":"2017","unstructured":"Khandare AL, Gourineni SR, Validandi V (2017) Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir India. Environ Monit Assess 189(11):579. https:\/\/doi.org\/10.1007\/s10661-017-6288-5","journal-title":"Environ Monit Assess"},{"key":"2651_CR25","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.chemosphere.2018.04.144","volume":"205","author":"D Linhares","year":"2018","unstructured":"Linhares D, Camarinho R, Garcia PV, Rodrigues ADS (2018) Mus musculus bone fluoride concentration as a useful biomarker for risk assessment of skeletal fluorosis in volcanic areas. Chemosphere 205:540\u2013544. https:\/\/doi.org\/10.1016\/j.chemosphere.2018.04.144","journal-title":"Chemosphere"},{"issue":"5","key":"2651_CR26","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s00204-015-1547-0","volume":"90","author":"G Liu","year":"2016","unstructured":"Liu G, Wang ZK, Wang ZY, Yang DB, Liu ZP, Wang L (2016) Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead. Arch Toxicol 90(5):1193\u20131209. https:\/\/doi.org\/10.1007\/s00204-015-1547-0","journal-title":"Arch Toxicol"},{"key":"2651_CR27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.tox.2017.03.016","volume":"383","author":"F Liu","year":"2017","unstructured":"Liu F, Wang XY, Zhou XP, Liu ZP, Song XB, Wang ZY, Wang L (2017) Cadmium disrupts autophagic flux by inhibiting cytosolic Ca(2+)-dependent autophagosome-lysosome fusion in primary rat proximal tubular cells. Toxicology 383:13\u201323. https:\/\/doi.org\/10.1016\/j.tox.2017.03.016","journal-title":"Toxicology"},{"issue":"4","key":"2651_CR28","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif) 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods (San Diego, Calif)"},{"issue":"6","key":"2651_CR29","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00204-012-0803-9","volume":"86","author":"Y Ma","year":"2012","unstructured":"Ma Y, Niu R, Sun Z, Wang J, Luo G, Zhang J, Wang J (2012) Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta. Arch Toxicol 86(6):849\u2013856. https:\/\/doi.org\/10.1007\/s00204-012-0803-9","journal-title":"Arch Toxicol"},{"key":"2651_CR30","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.chemosphere.2016.10.025","volume":"167","author":"Y Ma","year":"2017","unstructured":"Ma Y, Ma Z, Yin S, Yan X, Wang J (2017) Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere 167:454\u2013461. https:\/\/doi.org\/10.1016\/j.chemosphere.2016.10.025","journal-title":"Chemosphere"},{"key":"2651_CR31","doi-asserted-by":"crossref","unstructured":"Manthari RK, Tikka C, Ommati MM, Niu R, Sun Z, Wang J, Zhang J (2018) Arsenic-Induced Autophagy in the Developing Mouse Cerebellum: Involvement of the Blood-Brain Barrier's Tight-Junction Proteins and the PI3K-Akt-mTOR Signaling Pathway. 66(32):8602\u20138614 doi:10.1021\/acs.jafc.8b02654","DOI":"10.1021\/acs.jafc.8b02654"},{"key":"2651_CR32","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1196\/annals.1454.027","volume":"1140","author":"J Mendez-Gomez","year":"2008","unstructured":"Mendez-Gomez J, Garcia-Vargas GG, Lopez-Carrillo L, Calderon-Aranda ES, Gomez A, Vera E, Valverde M, Cebrian ME, Rojas E (2008) Genotoxic effects of environmental exposure to arsenic and lead on children in region Lagunera, Mexico. Ann N Y Acad Sci 1140:358\u2013367. https:\/\/doi.org\/10.1196\/annals.1454.027","journal-title":"Ann N Y Acad Sci"},{"issue":"9","key":"2651_CR33","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1039\/c8mt00192h","volume":"10","author":"M Mittal","year":"2018","unstructured":"Mittal M, Chatterjee S, Flora SJS (2018) Combination therapy with vitamin C and DMSA for arsenic-fluoride co-exposure in rats. Metallomics Integr Biometal Sci 10(9):1291\u20131306. https:\/\/doi.org\/10.1039\/c8mt00192h","journal-title":"Metallomics Integr Biometal Sci"},{"key":"2651_CR34","doi-asserted-by":"publisher","unstructured":"Nelson-Mora J, Escobar ML, Rodriguez-Duran L, Massieu L, Montiel T, Rodriguez VM, Hernandez-Mercado K, Gonsebatt ME (2018) Gestational exposure to inorganic arsenic (iAs3+) alters glutamate disposition in the mouse hippocampus and ionotropic glutamate receptor expression leading to memory impairment. 92(3):1037\u20131048. https:\/\/doi.org\/10.1007\/s00204-017-2111-x","DOI":"10.1007\/s00204-017-2111-x"},{"issue":"7","key":"2651_CR35","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1080\/15548627.2016.1178447","volume":"12","author":"S Park","year":"2016","unstructured":"Park S, Choi J, Biering SB, Dominici E, Williams LE, Hwang S (2016) Targeting by AutophaGy proteins (TAG): targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy 12(7):1153\u20131167. https:\/\/doi.org\/10.1080\/15548627.2016.1178447","journal-title":"Autophagy"},{"issue":"4","key":"2651_CR36","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/jat.3023","volume":"35","author":"R Recio-Vega","year":"2015","unstructured":"Recio-Vega R, Gonzalez-Cortes T, Olivas-Calderon E, Lantz RC, Gandolfi AJ, Gonzalez-De Alba C (2015) In utero and early childhood exposure to arsenic decreases lung function in children. J Appl Toxicol 35(4):358\u2013366. https:\/\/doi.org\/10.1002\/jat.3023","journal-title":"J Appl Toxicol"},{"issue":"3","key":"2651_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.toxlet.2011.03.023","volume":"203","author":"RA Rocha","year":"2011","unstructured":"Rocha RA, Gimeno-Alcaniz JV, Martin-Ibanez R, Canals JM, Velez D, Devesa V (2011) Arsenic and fluoride induce neural progenitor cell apoptosis. Toxicol Lett 203(3):237\u2013244. https:\/\/doi.org\/10.1016\/j.toxlet.2011.03.023","journal-title":"Toxicol Lett"},{"key":"2651_CR38","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.envint.2017.10.014","volume":"110","author":"N Saint-Jacques","year":"2018","unstructured":"Saint-Jacques N, Brown P, Nauta L, Boxall J, Parker L, Dummer TJB (2018) Estimating the risk of bladder and kidney cancer from exposure to low-levels of arsenic in drinking water, Nova Scotia, Canada. Environ Int 110:95\u2013104. https:\/\/doi.org\/10.1016\/j.envint.2017.10.014","journal-title":"Environ Int"},{"issue":"8","key":"2651_CR39","doi-asserted-by":"publisher","first-page":"6220","DOI":"10.1007\/s11356-014-3817-4","volume":"22","author":"AC Samal","year":"2015","unstructured":"Samal AC, Bhattacharya P, Mallick A, Ali MM, Pyne J, Santra SC (2015) A study to investigate fluoride contamination and fluoride exposure dose assessment in lateritic zones of West Bengal, India. Environ Sci Pollut Res Int 22(8):6220\u20136229. https:\/\/doi.org\/10.1007\/s11356-014-3817-4","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"2651_CR40","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/09603123.2014.958138","volume":"25","author":"K Sarkozi","year":"2015","unstructured":"Sarkozi K, Horvath E, Vezer T, Papp A, Paulik E (2015) Behavioral and general effects of subacute oral arsenic exposure in rats with and without fluoride. Int J Environ Health Res 25(4):418\u2013431. https:\/\/doi.org\/10.1080\/09603123.2014.958138","journal-title":"Int J Environ Health Res"},{"issue":"11","key":"2651_CR41","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1289\/ehp.1104867","volume":"120","author":"AH Smith","year":"2012","unstructured":"Smith AH, Marshall G, Liaw J, Yuan Y, Ferreccio C, Steinmaus C (2012) Mortality in young adults following in utero and childhood exposure to arsenic in drinking water. Environ Health Perspect 120(11):1527\u20131531. https:\/\/doi.org\/10.1289\/ehp.1104867","journal-title":"Environ Health Perspect"},{"issue":"6","key":"2651_CR42","doi-asserted-by":"publisher","first-page":"e2863","DOI":"10.1038\/cddis.2017.262","volume":"8","author":"XB Song","year":"2017","unstructured":"Song XB, Liu G, Liu F, Yan ZG, Wang ZY, Liu ZP, Wang L (2017) Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells. Cell Death Dis 8(6):e2863. https:\/\/doi.org\/10.1038\/cddis.2017.262","journal-title":"Cell Death Dis"},{"key":"2651_CR43","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.scitotenv.2019.04.409","volume":"686","author":"X Tian","year":"2019","unstructured":"Tian X, Feng J, Dong N, Lyu Y, Wei C, Li B, Ma Y, Xie J, Qiu Y, Song G, Ren X, Yan X (2019) Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring. Sci Total Environ 686:1229\u20131237. https:\/\/doi.org\/10.1016\/j.scitotenv.2019.04.409","journal-title":"Sci Total Environ"},{"key":"2651_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gexplo.2013.10.012","volume":"135","author":"D Wen","year":"2013","unstructured":"Wen D, Zhang F, Zhang E, Wang C, Han S, Zheng Y (2013) Arsenic, fluoride and iodine in groundwater of China. J Geochem Explor 135:1\u201321. https:\/\/doi.org\/10.1016\/j.gexplo.2013.10.012","journal-title":"J Geochem Explor"},{"issue":"1","key":"2651_CR45","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.envres.2006.05.008","volume":"103","author":"X Xiong","year":"2007","unstructured":"Xiong X, Liu J, He W, Xia T, He P, Chen X, Yang K, Wang A (2007) Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children. Environ Res 103(1):112\u2013116. https:\/\/doi.org\/10.1016\/j.envres.2006.05.008","journal-title":"Environ Res"},{"issue":"5","key":"2651_CR46","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/15548627.2017.1291113","volume":"13","author":"SI Yamashita","year":"2017","unstructured":"Yamashita SI, Kanki T (2017) How autophagy eats large mitochondria: autophagosome formation coupled with mitochondrial fragmentation. Autophagy 13(5):980\u2013981. https:\/\/doi.org\/10.1080\/15548627.2017.1291113","journal-title":"Autophagy"},{"key":"2651_CR47","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.chemosphere.2014.12.090","volume":"128","author":"X Yan","year":"2015","unstructured":"Yan X, Hao X, Nie Q, Feng C, Wang H, Sun Z, Niu R, Wang J (2015) Effects of fluoride on the ultrastructure and expression of Type I collagen in rat hard tissue. Chemosphere 128:36\u201341. https:\/\/doi.org\/10.1016\/j.chemosphere.2014.12.090","journal-title":"Chemosphere"},{"issue":"17","key":"2651_CR48","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1021\/acs.jafc.9b00312","volume":"67","author":"X Yan","year":"2019","unstructured":"Yan X, Dong N, Hao X, Xing Y, Tian X, Feng J, Xie J, Lv Y, Wei C, Gao Y, Qiu Y, Wang T (2019) Comparative transcriptomics reveals the role of the toll-like receptor signaling pathway in fluoride-induced cardiotoxicity. J Agric Food Chem 67(17):5033\u20135042. https:\/\/doi.org\/10.1021\/acs.jafc.9b00312","journal-title":"J Agric Food Chem"},{"issue":"2","key":"2651_CR49","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","volume":"14","author":"L Yu","year":"2018","unstructured":"Yu L, Chen Y, Tooze SA (2018) Autophagy pathway: cellular and molecular mechanisms. Autophagy 14(2):207\u2013215. https:\/\/doi.org\/10.1080\/15548627.2017.1378838","journal-title":"Autophagy"},{"issue":"1","key":"2651_CR50","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.etap.2013.11.027","volume":"37","author":"QB Zeng","year":"2014","unstructured":"Zeng QB, Xu YY, Yu X, Yang J, Hong F, Zhang AH (2014) Arsenic may be involved in fluoride-induced bone toxicity through PTH\/PKA\/AP1 signaling pathway. Environ Toxicol Pharmacol 37(1):228\u2013233. https:\/\/doi.org\/10.1016\/j.etap.2013.11.027","journal-title":"Environ Toxicol Pharmacol"},{"key":"2651_CR51","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bone.2019.03.016","volume":"123","author":"Q Zeng","year":"2019","unstructured":"Zeng Q, Xu Y, Yu X, Yang J, Hong F, Zhang A (2019) Silencing GSK3beta instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic. Bone 123:196\u2013203. https:\/\/doi.org\/10.1016\/j.bone.2019.03.016","journal-title":"Bone"},{"key":"2651_CR52","doi-asserted-by":"crossref","unstructured":"Zhang S, Niu Q, Gao H, Ma R, Lei R, Zhang C, Xia T, Li P, Xu C, Wang C, Chen J, Dong L, Zhao Q, Wang A (2016) Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environmental pollution (Barking, Essex : 1987) 212:97\u2013104 doi:10.1016\/j.envpol.2016.01.059","DOI":"10.1016\/j.envpol.2016.01.059"},{"issue":"1","key":"2651_CR53","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12882-018-0836-2","volume":"19","author":"YY Zhang","year":"2018","unstructured":"Zhang YY, Yang M, Bao JF, Gu LJ, Yu HL, Yuan WJ (2018) Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease. BMC Nephrol 19(1):45. https:\/\/doi.org\/10.1186\/s12882-018-0836-2","journal-title":"BMC Nephrol"},{"key":"2651_CR54","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.fct.2018.02.065","volume":"115","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Li Y, Gao Y, Yuan M, Manthari RK, Wang J, Wang J (2018a) TGF-beta1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells. Food Chem Toxicol 115:26\u201333. https:\/\/doi.org\/10.1016\/j.fct.2018.02.065","journal-title":"Food Chem Toxicol"},{"issue":"11","key":"2651_CR55","doi-asserted-by":"publisher","first-page":"3277","DOI":"10.1007\/s00204-018-2305-x","volume":"92","author":"Y Zhao","year":"2018","unstructured":"Zhao Y, Li Y, Wang J, Manthari RK, Wang J (2018b) Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes. Arch Toxicol 92(11):3277\u20133289. https:\/\/doi.org\/10.1007\/s00204-018-2305-x","journal-title":"Arch Toxicol"},{"key":"2651_CR56","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuro.2017.01.006","volume":"59","author":"YP Zhu","year":"2017","unstructured":"Zhu YP, Xi SH, Li MY, Ding TT, Liu N, Cao FY, Zeng Y, Liu XJ, Tong JW, Jiang SF (2017) Fluoride and arsenic exposure affects spatial memory and activates the ERK\/CREB signaling pathway in offspring rats. Neurotoxicology 59:56\u201364. https:\/\/doi.org\/10.1016\/j.neuro.2017.01.006","journal-title":"Neurotoxicology"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02651-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-019-02651-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-019-02651-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:11:11Z","timestamp":1607991071000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-019-02651-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,16]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["2651"],"URL":"https:\/\/doi.org\/10.1007\/s00204-019-02651-y","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,16]]},"assertion":[{"value":"2 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}