{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:38:44Z","timestamp":1780421924364,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["#11-RSNR-0019"],"award-info":[{"award-number":["#11-RSNR-0019"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00204-020-02666-w","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T08:02:36Z","timestamp":1581408156000},"page":"803-812","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolomics evaluation of repeated administration of potassium iodide on adult male rats"],"prefix":"10.1007","volume":"94","author":[{"given":"Cl\u00e9ment","family":"Rosique","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Lebsir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheherazade","family":"Benatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Guigon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Caire-Maurisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Benderitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00e2mar","family":"Souidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-0012","authenticated-orcid":false,"given":"Jean-Charles","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"issue":"1","key":"2666_CR1","first-page":"67","volume":"182","author":"M Benderitter","year":"2018","unstructured":"Benderitter M, Pourcher T, Martin J-C et al (2018) Do multiple administrations of stable iodine protect population chronically exposed to radioactive iodine: what is PRIODAC research program (2014\u201322) teaching us? Radiat Prot Dosim 182(1):67\u201379","journal-title":"Radiat Prot Dosim"},{"issue":"7","key":"2666_CR2","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1210\/jc.2016-3842","volume":"102","author":"EK Cahoon","year":"2017","unstructured":"Cahoon EK, Nadyrov EA, Polyanskaya ON et al (2017) Risk of Thyroid Nodules in Residents of Belarus Exposed to Chernobyl Fallout as Children and Adolescents. J Clin Endocrinol Metab 102(7):2207\u20132217. https:\/\/doi.org\/10.1210\/jc.2016-3842","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2666_CR3","doi-asserted-by":"publisher","first-page":"E692","DOI":"10.1152\/ajpendo.2000.278.4.E692","volume":"278","author":"B Corvilain","year":"2000","unstructured":"Corvilain B, Collyn L, van Sande J, Dumont JE (2000) Stimulation by iodide of H(2)O(2) generation in thyroid slices from several species. Am J Physiol Endocrinol Metab 278(4):E692\u2013E699. https:\/\/doi.org\/10.1152\/ajpendo.2000.278.4.E692","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2666_CR4","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13643-015-0106-3","volume":"4","author":"S Dreger","year":"2015","unstructured":"Dreger S, Pfinder M, Christianson L, Lhachimi SK, Zeeb H (2015) The effects of iodine blocking following nuclear accidents on thyroid cancer, hypothyroidism, and benign thyroid nodules: design of a systematic review. Syst Rev 4:126. https:\/\/doi.org\/10.1186\/s13643-015-0106-3","journal-title":"Syst Rev"},{"issue":"10","key":"2666_CR5","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.1096\/fj.201800330R","volume":"32","author":"J Fiamoncini","year":"2018","unstructured":"Fiamoncini J, Rundle M, Gibbons H et al (2018) Plasma metabolome analysis identifies distinct human metabotypes in the postprandial state with different susceptibility to weight loss-mediated metabolic improvements. FASEB J 32(10):5447\u20135458. https:\/\/doi.org\/10.1096\/fj.201800330R","journal-title":"FASEB J"},{"issue":"9","key":"2666_CR6","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/bioinformatics\/btu813","volume":"31","author":"F Giacomoni","year":"2015","unstructured":"Giacomoni F, Le Corguille G, Monsoor M et al (2015) Workflow4Metabolomics: a collaborative research infrastructure for computational metabolomics. Bioinformatics 31(9):1493\u20131495. https:\/\/doi.org\/10.1093\/bioinformatics\/btu813","journal-title":"Bioinformatics"},{"issue":"11","key":"2666_CR7","doi-asserted-by":"publisher","first-page":"e1000282","DOI":"10.1371\/journal.pgen.1000282","volume":"4","author":"C Gieger","year":"2008","unstructured":"Gieger C, Geistlinger L, Altmaier E et al (2008) Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet 4(11):e1000282","journal-title":"PLoS Genet"},{"issue":"6","key":"2666_CR8","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1007\/s11306-013-0544-7","volume":"9","author":"S Grison","year":"2013","unstructured":"Grison S, Fave G, Maillot M et al (2013) Metabolomics identifies a biological response to chronic low-dose natural uranium contamination in urine samples. Metabolomics 9(6):1168\u20131180","journal-title":"Metabolomics"},{"issue":"1","key":"2666_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1269\/jrr.11071","volume":"53","author":"S Grison","year":"2012","unstructured":"Grison S, Martin JC, Grandcolas L et al (2012) The metabolomic approach identifies a biological signature of low-dose chronic exposure to cesium 137. J Radiat Res (Tokyo) 53(1):33\u201343","journal-title":"J Radiat Res (Tokyo)"},{"key":"2666_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12892","author":"T Hendrikx","year":"2019","unstructured":"Hendrikx T, Schnabl B (2019) Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation. J Intern Med. https:\/\/doi.org\/10.1111\/joim.12892","journal-title":"J Intern Med"},{"issue":"3","key":"2666_CR11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/bioinformatics\/btr661","volume":"28","author":"A Karnovsky","year":"2011","unstructured":"Karnovsky A, Weymouth T, Hull T et al (2011) Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data. Bioinformatics 28(3):373\u2013380","journal-title":"Bioinformatics"},{"key":"2666_CR12","doi-asserted-by":"crossref","unstructured":"Lebsir D, Cohen D, Manens L, et al. (2018a) Toxicology of repeated iodine thyroid blocking in adult rat. J Pharm Res3(1):1\u20138. https:\/\/opastonline.com\/wp-content\/uploads\/2018\/04\/toxicology-of-repeated-iodine-thyroid-blocking-in-adult-rat-jpr-18-002.pdf. (ISSN: 2573-962X)","DOI":"10.33140\/JPR.03.01.2"},{"key":"2666_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.mce.2018.02.017","volume":"474","author":"D Lebsir","year":"2018","unstructured":"Lebsir D, Manens L, Grison S et al (2018) Effects of repeated potassium iodide administration on genes involved in synthesis and secretion of thyroid hormone in adult male rat. Mol Cell Endocrinol 474:119\u2013126. https:\/\/doi.org\/10.1016\/j.mce.2018.02.017","journal-title":"Mol Cell Endocrinol"},{"key":"2666_CR14","doi-asserted-by":"publisher","first-page":"9740353","DOI":"10.1155\/2016\/9740353","volume":"2016","author":"P Lestaevel","year":"2016","unstructured":"Lestaevel P, Grison S, Fav\u00e9 G, Elie C, Dhieux B, Martin JC, Tack K, Souidi M (2016) Assessment of the central effects of natural uranium viabehavioural performances and the cerebrospinal fluid metabolome. Neural Plast. 2016:9740353. https:\/\/doi.org\/10.1155\/2016\/9740353","journal-title":"Neural Plast."},{"issue":"2","key":"2666_CR15","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1210\/endo-118-2-632","volume":"118","author":"ML Maayan","year":"1986","unstructured":"Maayan ML, Sellitto RV, Volpert EM (1986) Dopamine and L-dopa: inhibition of thyrotropin-stimulated thyroidal thyroxine release. Endocrinology 118(2):632\u2013636. https:\/\/doi.org\/10.1210\/endo-118-2-632","journal-title":"Endocrinology"},{"issue":"4","key":"2666_CR16","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s11306-014-0740-0","volume":"11","author":"J-C Martin","year":"2015","unstructured":"Martin J-C, Maillot M, Mazerolles G et al (2015a) Can we trust untargeted metabolomics? Results of the metabo-ring initiative, a large-scale, multi-instrument inter-laboratory study. Metabolomics 11(4):807\u2013821","journal-title":"Metabolomics"},{"key":"2666_CR17","doi-asserted-by":"publisher","first-page":"H935","DOI":"10.1152\/ajpheart.00032.2015","volume":"309","author":"JC Martin","year":"2015","unstructured":"Martin JC, Berton A, Ginies C et al (2015b) Multi-level systems biology modeling characterized the atheroprotective efficiencies of modified dairy fats in a hamster model. Am J Physiol Heart Circ Physiol 309:H935\u2013H945. https:\/\/doi.org\/10.1152\/ajpheart.00032.2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"2666_CR18","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1210\/endo-93-1-193","volume":"93","author":"A Melander","year":"1973","unstructured":"Melander A, Sundler F, Westgren U (1973) Intrathyroidal amines and the synthesis of thyroid hormone. Endocrinology 93(1):193\u2013200. https:\/\/doi.org\/10.1210\/endo-93-1-193","journal-title":"Endocrinology"},{"issue":"2","key":"2666_CR19","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1152\/physrev.00030.2013","volume":"94","author":"R Mullur","year":"2014","unstructured":"Mullur R, Liu YY, Brent GA (2014) Thyroid hormone regulation of metabolism. Physiol Rev 94(2):355\u2013382. https:\/\/doi.org\/10.1152\/physrev.00030.2013","journal-title":"Physiol Rev"},{"issue":"1","key":"2666_CR20","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1210\/en.2008-0345","volume":"150","author":"JP Nicola","year":"2009","unstructured":"Nicola JP, Velez ML, Lucero AM, Fozzatti L, Pellizas CG, Masini-Repiso AM (2009) Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells. Endocrinology 150(1):500\u2013508. https:\/\/doi.org\/10.1210\/en.2008-0345","journal-title":"Endocrinology"},{"issue":"5","key":"2666_CR21","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/mnfr.201000458","volume":"55","author":"A O'Sullivan","year":"2011","unstructured":"O'Sullivan A, Gibney MJ, Connor AO et al (2011) Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res 55(5):679\u2013690. https:\/\/doi.org\/10.1002\/mnfr.201000458","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"2666_CR22","doi-asserted-by":"publisher","first-page":"155932581774655","DOI":"10.1177\/1559325817746558","volume":"15","author":"G Phan","year":"2017","unstructured":"Phan G, Rebiere F, Suhard D et al (2017) Optimal KI prophylactic dose determination for thyroid radiation protection after a single administration in adult rats. Dose Response 15(4):1559325817746558. https:\/\/doi.org\/10.1177\/1559325817746558","journal-title":"Dose Response"},{"issue":"1","key":"2666_CR23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12916-016-0770-8","volume":"15","author":"M Pietzner","year":"2017","unstructured":"Pietzner M, Engelmann B, Kacprowski T et al (2017) Plasma proteome and metabolome characterization of an experimental human thyrotoxicosis model. BMC Med 15(1):6. https:\/\/doi.org\/10.1186\/s12916-016-0770-8","journal-title":"BMC Med"},{"issue":"1","key":"2666_CR24","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/JOE-18-0117","volume":"238","author":"M Pietzner","year":"2018","unstructured":"Pietzner M, Kacprowski T, Friedrich N (2018) Empowering thyroid hormone research in human subjects using OMICs technologies. J Endocrinol 238(1):R13\u2013R29. https:\/\/doi.org\/10.1530\/JOE-18-0117","journal-title":"J Endocrinol"},{"key":"2666_CR25","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.biocel.2017.07.024","volume":"93","author":"C Piras","year":"2017","unstructured":"Piras C, Arisci N, Poddighe S, Liggi S, Mariotti S, Atzori L (2017) Metabolomic profile in hyperthyroid patients before and after antithyroid drug treatment: Correlation with thyroid hormone and TSH concentration. Int J Biochem Cell Biol 93:119\u2013128. https:\/\/doi.org\/10.1016\/j.biocel.2017.07.024","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"2666_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1037\/a0035942","volume":"121","author":"DS Ramsay","year":"2014","unstructured":"Ramsay DS, Woods SC (2014) Clarifying the roles of homeostasis and allostasis in physiological regulation. Psychol Rev 121(2):225\u2013247. https:\/\/doi.org\/10.1037\/a0035942","journal-title":"Psychol Rev"},{"issue":"3","key":"2666_CR27","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cmet.2016.08.004","volume":"24","author":"DS Ramsay","year":"2016","unstructured":"Ramsay DS, Woods SC (2016) Physiological regulation: how it really works. Cell Metab 24(3):361\u2013364. https:\/\/doi.org\/10.1016\/j.cmet.2016.08.004","journal-title":"Cell Metab"},{"key":"2666_CR28","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2019.1625474","author":"C Rosique","year":"2019","unstructured":"Rosique C, Lebsir D, Lestaevel P et al (2019) Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics. J Toxicol Environ Health A. https:\/\/doi.org\/10.1080\/15287394.2019.1625474","journal-title":"J Toxicol Environ Health A"},{"issue":"11","key":"2666_CR29","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504","journal-title":"Genome Res"},{"key":"2666_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-019-09687-1","author":"H Shen","year":"2019","unstructured":"Shen H, Han J, Li Y et al (2019) Different host-specific responses in thyroid function and gut microbiota modulation between diet-induced obese and normal mice given the same dose of iodine. Appl Microbiol Biotechnol. https:\/\/doi.org\/10.1007\/s00253-019-09687-1","journal-title":"Appl Microbiol Biotechnol"},{"key":"2666_CR31","unstructured":"Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J (eds) Handbook of life stress, cognition and health. Wiley, New York, pp 629\u2013649. https:\/\/retina.anatomy.upenn.edu\/pdfiles\/5446.pdf"},{"issue":"52","key":"2666_CR32","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1194\/jlr.M013391","volume":"7","author":"C Thabuis","year":"2011","unstructured":"Thabuis C, Destaillats F, Lambert D et al (2011) Lipid transport function is the main target of oral oleylethanolamide to reduce adiposity in high-fat fed mice. J Lipid Res 7(52):1373\u20131382","journal-title":"J Lipid Res"},{"issue":"3","key":"2666_CR33","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s12020-014-0509-2","volume":"49","author":"C Virili","year":"2015","unstructured":"Virili C, Centanni M (2015) Does microbiota composition affect thyroid homeostasis? Endocrine 49(3):583\u2013587. https:\/\/doi.org\/10.1007\/s12020-014-0509-2","journal-title":"Endocrine"},{"issue":"1","key":"2666_CR34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","volume":"8","author":"EJ Want","year":"2012","unstructured":"Want EJ, Masson P, Michopoulos F et al (2012) Global metabolic profiling of animal and human tissues via UPLC-MS. Nat Protoc 8(1):17\u201332","journal-title":"Nat Protoc"},{"key":"2666_CR35","unstructured":"WHO (2017) Iodine thyroid blocking: Guidelines for use in planning for and responding to radiological and nuclear emergencies. World Health Organization. https:\/\/www.who.int\/iris\/handle\/10665\/259510. Licence: CC BY-NC-SA 3.0 IGO"},{"issue":"10","key":"2666_CR36","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1073\/pnas.0812874106","volume":"106","author":"WR Wikoff","year":"2009","unstructured":"Wikoff WR, Anfora AT, Liu J et al (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 106(10):3698\u20133703","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2666_CR37","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0021-9258(18)57335-X","volume":"174","author":"J Wolff","year":"1948","unstructured":"Wolff J, Chaikoff IL (1948) Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem 174(2):555\u2013564","journal-title":"J Biol Chem"},{"issue":"2","key":"2666_CR38","doi-asserted-by":"publisher","first-page":"e55599","DOI":"10.1371\/journal.pone.0055599","volume":"8","author":"S Wu","year":"2013","unstructured":"Wu S, Tan G, Dong X et al (2013) Metabolic profiling provides a system understanding of hypothyroidism in rats and its application. PLoS ONE 8(2):e55599. https:\/\/doi.org\/10.1371\/journal.pone.0055599","journal-title":"PLoS ONE"},{"issue":"2","key":"2666_CR39","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1039\/C0MB00066C","volume":"7","author":"P Wurtz","year":"2011","unstructured":"Wurtz P, Soininen P, Kangas AJ et al (2011) Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis. Mol Biosyst 7(2):385\u2013393","journal-title":"Mol Biosyst"},{"key":"2666_CR40","doi-asserted-by":"crossref","unstructured":"Xia J, Psychogios N, Young N, Wishart DS (2009) MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucl Acids Res 37(suppl_2):W652\u2013W660 doi:10.1093\/nar\/gkp356. https:\/\/academic.oup.com\/nar\/article\/37\/suppl_2\/W652\/1137529","DOI":"10.1093\/nar\/gkp356"},{"issue":"1","key":"2666_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1089\/thy.2009.0242","volume":"20","author":"K Yamazaki","year":"2010","unstructured":"Yamazaki K, Tanigawa K, Suzuki K et al (2010) Iodide-induced chemokines and genes related to immunological function in cultured human thyroid follicles in the presence of thyrotropin. Thyroid 20(1):67\u201376. https:\/\/doi.org\/10.1089\/thy.2009.0242","journal-title":"Thyroid"},{"issue":"2","key":"2666_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1089\/105072503321319459","volume":"13","author":"K Yamazaki","year":"2003","unstructured":"Yamazaki K, Yamada E, Kanaji Y et al (2003) Genes regulated by thyrotropin and iodide in cultured human thyroid follicles: analysis by cDNA microarray. Thyroid 13(2):149\u2013158. https:\/\/doi.org\/10.1089\/105072503321319459","journal-title":"Thyroid"},{"issue":"6","key":"2666_CR43","doi-asserted-by":"publisher","first-page":"5531","DOI":"10.3168\/jds.2017-13977","volume":"101","author":"F Zandkarimi","year":"2018","unstructured":"Zandkarimi F, Vanegas J, Fern X, Maier CS, Bobe G (2018) Metabotypes with elevated protein and lipid catabolism and inflammation precede clinical mastitis in prepartal transition dairy cows. J Dairy Sci 101(6):5531\u20135548. https:\/\/doi.org\/10.3168\/jds.2017-13977","journal-title":"J Dairy Sci"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-020-02666-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00204-020-02666-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-020-02666-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T06:59:08Z","timestamp":1612940348000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00204-020-02666-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,11]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["2666"],"URL":"https:\/\/doi.org\/10.1007\/s00204-020-02666-w","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,11]]},"assertion":[{"value":"2 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}