{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:44:50Z","timestamp":1785926690353,"version":"3.56.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00204-020-02753-y","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T19:02:59Z","timestamp":1588705379000},"page":"2401-2411","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The role of hepatic cytochrome P450s in the cytotoxicity of sertraline"],"prefix":"10.1007","volume":"94","author":[{"given":"Si","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bryant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baitang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"issue":"6","key":"2753_CR1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1055\/s-0043-100934","volume":"83","author":"AA Albassam","year":"2017","unstructured":"Albassam AA, Markowitz JS (2017) An appraisal of drug\u2013drug interactions with green tea (Camellia sinensis). Planta Med 83(6):496\u2013508. https:\/\/doi.org\/10.1055\/s-0043-100934","journal-title":"Planta Med"},{"key":"2753_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.etap.2018.05.021","volume":"61","author":"MI Almansour","year":"2018","unstructured":"Almansour MI, Jarrar YB, Jarrar BM (2018) In vivo investigation on the chronic hepatotoxicity induced by sertraline. Environ Toxicol Pharmacol 61:107\u2013115. https:\/\/doi.org\/10.1016\/j.etap.2018.05.021","journal-title":"Environ Toxicol Pharmacol"},{"key":"2753_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/ijms19092765","volume":"19","author":"CA Austin","year":"2018","unstructured":"Austin CA, Lee KC, Swan RL et al (2018) TOP2B: the first thirty years. Int J Mol Sci 19:9. https:\/\/doi.org\/10.3390\/ijms19092765","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2753_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1080\/00926239608404912","volume":"22","author":"R Balon","year":"1996","unstructured":"Balon R (1996) Antidepressants in the treatment of premature ejaculation. J Sex Marital Ther 22(2):85\u201396. https:\/\/doi.org\/10.1080\/00926239608404912","journal-title":"J Sex Marital Ther"},{"key":"2753_CR5","doi-asserted-by":"publisher","first-page":"105337","DOI":"10.1016\/j.aquatox.2019.105337","volume":"218","author":"E Byeon","year":"2019","unstructured":"Byeon E, Park JC, Hagiwara A, Han J, Lee JS (2019) Two antidepressants fluoxetine and sertraline cause growth retardation and oxidative stress in the marine rotifer Brachionus koreanus. Aquat Toxicol 218:105337. https:\/\/doi.org\/10.1016\/j.aquatox.2019.105337","journal-title":"Aquat Toxicol"},{"issue":"1","key":"2753_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.toxlet.2013.05.641","volume":"221","author":"S Chen","year":"2013","unstructured":"Chen S, Wan L, Couch L et al (2013) Mechanism study of goldenseal-associated DNA damage. Toxicol Lett 221(1):64\u201372. https:\/\/doi.org\/10.1016\/j.toxlet.2013.05.641","journal-title":"Toxicol Lett"},{"key":"2753_CR7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tox.2014.05.007","volume":"322","author":"S Chen","year":"2014","unstructured":"Chen S, Xuan J, Couch L et al (2014a) Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology 322:78\u201388. https:\/\/doi.org\/10.1016\/j.tox.2014.05.007","journal-title":"Toxicology"},{"issue":"2","key":"2753_CR8","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/toxsci\/kft254","volume":"137","author":"S Chen","year":"2014","unstructured":"Chen S, Xuan J, Wan L et al (2014b) Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci 137(2):404\u2013415. https:\/\/doi.org\/10.1093\/toxsci\/kft254","journal-title":"Toxicol Sci"},{"issue":"3","key":"2753_CR9","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s00204-016-1775-y","volume":"91","author":"S Chen","year":"2017","unstructured":"Chen S, Zhang Z, Qing T et al (2017) Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. Arch Toxicol 91(3):1293\u20131307. https:\/\/doi.org\/10.1007\/s00204-016-1775-y","journal-title":"Arch Toxicol"},{"issue":"4","key":"2753_CR10","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/em.22173","volume":"59","author":"S Chen","year":"2018","unstructured":"Chen S, Ren Z, Yu D, Ning B, Guo L (2018a) DNA damage-induced apoptosis and mitogen-activated protein kinase pathway contribute to the toxicity of dronedarone in hepatic cells. Environ Mol Mutagen 59(4):278\u2013289. https:\/\/doi.org\/10.1002\/em.22173","journal-title":"Environ Mol Mutagen"},{"issue":"6","key":"2753_CR11","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1007\/s00204-018-2196-x","volume":"92","author":"S Chen","year":"2018","unstructured":"Chen S, Wu Q, Ning B, Bryant M, Guo L (2018b) The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone. Arch Toxicol 92(6):1969\u20131981. https:\/\/doi.org\/10.1007\/s00204-018-2196-x","journal-title":"Arch Toxicol"},{"issue":"11","key":"2753_CR12","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.4088\/jcp.v69n1108","volume":"69","author":"A Cipriani","year":"2008","unstructured":"Cipriani A, Furukawa TA, Geddes JR et al (2008) Does randomized evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis. J Clin Psychiatry 69(11):1732\u20131742. https:\/\/doi.org\/10.4088\/jcp.v69n1108","journal-title":"J Clin Psychiatry"},{"key":"2753_CR13","unstructured":"clincalc.com (2019) The Top 300 of 2019. https:\/\/clincalc.com\/DrugStats\/Top300Drugs.aspx"},{"issue":"1","key":"2753_CR14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S1130-6343(08)72814-9","volume":"32","author":"V Collados Arroyo","year":"2008","unstructured":"Collados Arroyo V, Plaza Aniorte J, Hallal H, Perez-Cuadrado E (2008) Sertraline-induced hepatotoxicity. Farm Hosp 32(1):60\u201361","journal-title":"Farm Hosp"},{"issue":"6","key":"2753_CR15","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1007\/s10620-010-1192-7","volume":"55","author":"V Collados","year":"2010","unstructured":"Collados V, Hallal H, Andrade RJ (2010) Sertraline hepatotoxicity: report of a case and review of the literature. Dig Dis Sci 55(6):1806\u20131807. https:\/\/doi.org\/10.1007\/s10620-010-1192-7","journal-title":"Dig Dis Sci"},{"issue":"15","key":"2753_CR16","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.2165\/00003088-200241150-00002","volume":"41","author":"CL DeVane","year":"2002","unstructured":"DeVane CL, Liston HL, Markowitz JS (2002) Clinical pharmacokinetics of sertraline. Clin Pharmacokinet 41(15):1247\u20131266. https:\/\/doi.org\/10.2165\/00003088-200241150-00002","journal-title":"Clin Pharmacokinet"},{"issue":"3","key":"2753_CR17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3109\/03602532.2015.1076438","volume":"47","author":"DF Dluzen","year":"2015","unstructured":"Dluzen DF, Lazarus P (2015) MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors. Drug Metab Rev 47(3):320\u2013334. https:\/\/doi.org\/10.3109\/03602532.2015.1076438","journal-title":"Drug Metab Rev"},{"issue":"5","key":"2753_CR18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/bies.20027","volume":"26","author":"MD Evans","year":"2004","unstructured":"Evans MD, Cooke MS (2004) Factors contributing to the outcome of oxidative damage to nucleic acids. BioEssays 26(5):533\u2013542. https:\/\/doi.org\/10.1002\/bies.20027","journal-title":"BioEssays"},{"issue":"5","key":"2753_CR19","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/s0168-8278(01)00159-3","volume":"35","author":"L Fartoux-Heymann","year":"2001","unstructured":"Fartoux-Heymann L, Hezode C, Zafrani ES, Dhumeaux D, Mallat A (2001) Acute fatal hepatitis related to sertraline. J Hepatol 35(5):683\u2013684. https:\/\/doi.org\/10.1016\/s0168-8278(01)00159-3","journal-title":"J Hepatol"},{"issue":"3","key":"2753_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2174\/1389200043335577","volume":"5","author":"C Fradette","year":"2004","unstructured":"Fradette C, Du Souich P (2004) Effect of hypoxia on cytochrome P450 activity and expression. Curr Drug Metab 5(3):257\u2013271. https:\/\/doi.org\/10.2174\/1389200043335577","journal-title":"Curr Drug Metab"},{"issue":"12","key":"2753_CR21","first-page":"822","volume":"93","author":"JL Galan Navarro","year":"2001","unstructured":"Galan Navarro JL (2001) Acute cholestatic hepatitis probably caused by sertraline. Rev Esp Enferm Dig 93(12):822","journal-title":"Rev Esp Enferm Dig"},{"issue":"6","key":"2753_CR22","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1124\/mol.105.014753","volume":"68","author":"MD Gray","year":"2005","unstructured":"Gray MD, Mann M, Nitiss JL, Hendershot LM (2005) Activation of the unfolded protein response is necessary and sufficient for reducing topoisomerase IIalpha protein levels and decreasing sensitivity to topoisomerase-targeted drugs. Mol Pharmacol 68(6):1699\u20131707. https:\/\/doi.org\/10.1124\/mol.105.014753","journal-title":"Mol Pharmacol"},{"key":"2753_CR23","unstructured":"Grohol JM (2018) Top 25 psychiatric medications for 2016. Psych Central https:\/\/psychcentral.com\/blog\/top-25-psychiatric-medications-for-2016\/"},{"issue":"2","key":"2753_CR24","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.fct.2008.11.037","volume":"47","author":"L Guo","year":"2009","unstructured":"Guo L, Li Q, Xia Q, Dial S, Chan PC, Fu P (2009) Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract. Food Chem Toxicol 47(2):433\u2013442","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"2753_CR25","first-page":"364","volume":"22","author":"ML Hautekeete","year":"1998","unstructured":"Hautekeete ML, Colle I, van Vlierberghe H, Elewaut A (1998) Symptomatic liver injury probably related to sertraline. Gastroenterol Clin Biol 22(3):364\u2013365","journal-title":"Gastroenterol Clin Biol"},{"issue":"3","key":"2753_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/clpt.2013.192","volume":"95","author":"MT Holmberg","year":"2014","unstructured":"Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M (2014) Grapefruit juice inhibits the metabolic activation of clopidogrel. Clin Pharmacol Ther 95(3):307\u2013313. https:\/\/doi.org\/10.1038\/clpt.2013.192","journal-title":"Clin Pharmacol Ther"},{"key":"2753_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz158","author":"TH Holmes","year":"2019","unstructured":"Holmes TH, Winn LM (2019) DNA damage and perturbed topoisomerase iialpha as a target of 1,4-benzoquinone toxicity in murine fetal liver cells. Toxicol Sci. https:\/\/doi.org\/10.1093\/toxsci\/kfz158","journal-title":"Toxicol Sci"},{"key":"2753_CR28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.bcp.2016.06.007","volume":"113","author":"Y Jin","year":"2016","unstructured":"Jin Y, Yu D, Tolleson WH et al (2016) MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes. Biochem Pharmacol 113:88\u201396. https:\/\/doi.org\/10.1016\/j.bcp.2016.06.007","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"2753_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3181\/00379727-217-44240","volume":"217","author":"WK Kaufmann","year":"1998","unstructured":"Kaufmann WK (1998) Human topoisomerase II function, tyrosine phosphorylation and cell cycle checkpoints. Proc Soc Exp Biol Med 217(3):327\u2013334. https:\/\/doi.org\/10.3181\/00379727-217-44240","journal-title":"Proc Soc Exp Biol Med"},{"issue":"3","key":"2753_CR30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1345\/aph.18155","volume":"33","author":"KY Kim","year":"1999","unstructured":"Kim KY, Hwang W, Narendran R (1999) Acute liver damage possibly related to sertraline and venlafaxine ingestion. Ann Pharmacother 33(3):381\u2013382. https:\/\/doi.org\/10.1345\/aph.18155","journal-title":"Ann Pharmacother"},{"issue":"7","key":"2753_CR31","first-page":"763","volume":"27","author":"K Kobayashi","year":"1999","unstructured":"Kobayashi K, Ishizuka T, Shimada N, Yoshimura Y, Kamijima K, Chiba K (1999) Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro. Drug Metab Dispos 27(7):763\u2013766","journal-title":"Drug Metab Dispos"},{"key":"2753_CR32","first-page":"295","volume":"5","author":"AK Larsen","year":"2003","unstructured":"Larsen AK, Escargueil AE, Skladanowski A (2003) From DNA damage to G2 arrest: the many roles of topoisomerase II. Prog Cell Cycle Res 5:295\u2013300","journal-title":"Prog Cell Cycle Res"},{"issue":"11","key":"2753_CR33","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0149-2918(00)86737-5","volume":"21","author":"AJ Lee","year":"1999","unstructured":"Lee AJ, Chan WK, Harralson AF, Buffum J, Bui BC (1999) The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clin Ther 21(11):1890\u20131899. https:\/\/doi.org\/10.1016\/S0149-2918(00)86737-5","journal-title":"Clin Ther"},{"issue":"2","key":"2753_CR34","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1093\/toxsci\/kfs100","volume":"127","author":"Y Li","year":"2012","unstructured":"Li Y, Couch L, Higuchi M, Fang JL, Guo L (2012) Mitochondrial dysfunction induced by sertraline, an antidepressant agent. Toxicol Sci 127(2):582\u2013591. https:\/\/doi.org\/10.1093\/toxsci\/kfs100","journal-title":"Toxicol Sci"},{"issue":"1","key":"2753_CR35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1124\/jpet.104.079608","volume":"313","author":"HL Lin","year":"2005","unstructured":"Lin HL, Kent UM, Hollenberg PF (2005) The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5. J Pharmacol Exp Ther 313(1):154\u2013164. https:\/\/doi.org\/10.1124\/jpet.104.079608","journal-title":"J Pharmacol Exp Ther"},{"key":"2753_CR36","doi-asserted-by":"publisher","first-page":"CD001396","DOI":"10.1002\/14651858.CD001396.pub3","volume":"6","author":"J Marjoribanks","year":"2013","unstructured":"Marjoribanks J, Brown J, O'Brien PM, Wyatt K (2013) Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst Rev 6:CD001396. https:\/\/doi.org\/10.1002\/14651858.CD001396.pub3","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"2753_CR37","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/bdd.1857","volume":"34","author":"Y Masubuchi","year":"2013","unstructured":"Masubuchi Y, Kawaguchi Y (2013) Time-dependent inhibition of CYP3A4 by sertraline, a selective serotonin reuptake inhibitor. Biopharm Drug Dispos 34(8):423\u2013430. https:\/\/doi.org\/10.1002\/bdd.1857","journal-title":"Biopharm Drug Dispos"},{"issue":"5","key":"2753_CR38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/00004714-199510000-00006","volume":"15","author":"J Mendels","year":"1995","unstructured":"Mendels J, Camera A, Sikes C (1995) Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 15(5):341\u2013346. https:\/\/doi.org\/10.1097\/00004714-199510000-00006","journal-title":"J Clin Psychopharmacol"},{"issue":"4","key":"2753_CR39","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1083\/jcb.136.4.775","volume":"136","author":"KN Meyer","year":"1997","unstructured":"Meyer KN, Kjeldsen E, Straub T et al (1997) Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities. J Cell Biol 136(4):775\u2013788. https:\/\/doi.org\/10.1083\/jcb.136.4.775","journal-title":"J Cell Biol"},{"issue":"5","key":"2753_CR40","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1023\/a:1023007831047","volume":"48","author":"S Persky","year":"2003","unstructured":"Persky S, Reinus JF (2003) Sertraline hepatotoxicity: a case report and review of the literature on selective serotonin reuptake inhibitor hepatotoxicity. Dig Dis Sci 48(5):939\u2013944. https:\/\/doi.org\/10.1023\/a:1023007831047","journal-title":"Dig Dis Sci"},{"issue":"1","key":"2753_CR41","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1124\/jpet.114.214189","volume":"350","author":"KL Poulsen","year":"2014","unstructured":"Poulsen KL, Olivero-Verbel J, Beggs KM, Ganey PE, Roth RA (2014) Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-alpha by macrophages: role of the DNA damage response. J Pharmacol Exp Ther 350(1):164\u2013170. https:\/\/doi.org\/10.1124\/jpet.114.214189","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"2753_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/138920010791110917","volume":"11","author":"S Rendic","year":"2010","unstructured":"Rendic S, Guengerich FP (2010) Update information on drug metabolism systems\u20142009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters. Curr Drug Metab 11(1):4\u201384. https:\/\/doi.org\/10.2174\/138920010791110917","journal-title":"Curr Drug Metab"},{"issue":"6","key":"2753_CR43","doi-asserted-by":"publisher","first-page":"787","DOI":"10.2174\/138920012800840356","volume":"13","author":"S Rendic","year":"2012","unstructured":"Rendic S, Guengerich FP (2012) Summary of information on the effects of ionizing and non-ionizing radiation on cytochrome P450 and other drug metabolizing enzymes and transporters. Curr Drug Metab 13(6):787\u2013814. https:\/\/doi.org\/10.2174\/138920012800840356","journal-title":"Curr Drug Metab"},{"issue":"6","key":"2753_CR44","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1124\/dmd.114.062844","volume":"43","author":"JK Rieger","year":"2015","unstructured":"Rieger JK, Reutter S, Hofmann U, Schwab M, Zanger UM (2015) Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9. Drug Metab Dispos 43(6):884\u2013888. https:\/\/doi.org\/10.1124\/dmd.114.062844","journal-title":"Drug Metab Dispos"},{"issue":"6 Pt 2","key":"2753_CR45","first-page":"84S","volume":"15","author":"C Riesenman","year":"1995","unstructured":"Riesenman C (1995) Antidepressant drug interactions and the cytochrome P450 system: a critical appraisal. Pharmacotherapy 15(6 Pt 2):84S\u201399S","journal-title":"Pharmacotherapy"},{"issue":"5","key":"2753_CR46","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/bcpt.12938","volume":"122","author":"M Saiz-Rodriguez","year":"2018","unstructured":"Saiz-Rodriguez M, Belmonte C, Roman M et al (2018) Effect of polymorphisms on the pharmacokinetics, pharmacodynamics and safety of sertraline in healthy volunteers. Basic Clin Pharmacol Toxicol 122(5):501\u2013511. https:\/\/doi.org\/10.1111\/bcpt.12938","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2753_CR47","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40780-017-0083-x","volume":"3","author":"T Sasaki","year":"2017","unstructured":"Sasaki T, Sato Y, Kumagai T, Yoshinari K, Nagata K (2017) Effect of health foods on cytochrome P450-mediated drug metabolism. J Pharm Health Care Sci 3:14. https:\/\/doi.org\/10.1186\/s40780-017-0083-x","journal-title":"J Pharm Health Care Sci"},{"key":"2753_CR48","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/978-1-61779-998-3_40","volume":"920","author":"A Sharma","year":"2012","unstructured":"Sharma A, Singh K, Almasan A (2012) Histone H2AX phosphorylation: a marker for DNA damage. Methods Mol Biol 920:613\u2013626. https:\/\/doi.org\/10.1007\/978-1-61779-998-3_40","journal-title":"Methods Mol Biol"},{"issue":"2","key":"2753_CR49","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1006\/abbi.2000.1835","volume":"378","author":"W Tassaneeyakul","year":"2000","unstructured":"Tassaneeyakul W, Guo LQ, Fukuda K, Ohta T, Yamazoe Y (2000) Inhibition selectivity of grapefruit juice components on human cytochromes P450. Arch Biochem Biophys 378(2):356\u2013363. https:\/\/doi.org\/10.1006\/abbi.2000.1835","journal-title":"Arch Biochem Biophys"},{"issue":"4 Pt 3","key":"2753_CR50","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1080\/15622970802688069","volume":"10","author":"N Ueda","year":"2009","unstructured":"Ueda N, Yoshimura R, Umene-Nakano W et al (2009) Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers. World J Biol Psychiatry 10(4 Pt 3):832\u2013835. https:\/\/doi.org\/10.1080\/15622970802688069","journal-title":"World J Biol Psychiatry"},{"issue":"12","key":"2753_CR51","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1111\/j.1532-5415.2000.tb03879.x","volume":"48","author":"MM Verrico","year":"2000","unstructured":"Verrico MM, Nace DA, Towers AL (2000) Fulminant chemical hepatitis possibly associated with donepezil and sertraline therapy. J Am Geriatr Soc 48(12):1659\u20131663. https:\/\/doi.org\/10.1111\/j.1532-5415.2000.tb03879.x","journal-title":"J Am Geriatr Soc"},{"key":"2753_CR52","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.toxlet.2016.04.016","volume":"253","author":"Q Wu","year":"2016","unstructured":"Wu Q, Ning B, Xuan J, Ren Z, Guo L, Bryant MS (2016) The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity. Toxicol Lett 253:55\u201362. https:\/\/doi.org\/10.1016\/j.toxlet.2016.04.016","journal-title":"Toxicol Lett"},{"issue":"3","key":"2753_CR53","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1046\/j.1365-2125.1999.00023.x","volume":"48","author":"ZH Xu","year":"1999","unstructured":"Xu ZH, Wang W, Zhao XJ et al (1999) Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes. Br J Clin Pharmacol 48(3):416\u2013423. https:\/\/doi.org\/10.1046\/j.1365-2125.1999.00023.x","journal-title":"Br J Clin Pharmacol"},{"key":"2753_CR54","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.cbi.2015.10.009","volume":"255","author":"J Xuan","year":"2016","unstructured":"Xuan J, Chen S, Ning B, Tolleson WH, Guo L (2016) Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity. Chem Biol Interact 255:63\u201373. https:\/\/doi.org\/10.1016\/j.cbi.2015.10.009","journal-title":"Chem Biol Interact"},{"issue":"4","key":"2753_CR55","doi-asserted-by":"publisher","first-page":"e60368","DOI":"10.1371\/journal.pone.0060368","volume":"8","author":"L Yang","year":"2013","unstructured":"Yang L, Price ET, Chang CW et al (2013) Gene expression variability in human hepatic drug metabolizing enzymes and transporters. PLoS ONE 8(4):e60368. https:\/\/doi.org\/10.1371\/journal.pone.0060368","journal-title":"PLoS ONE"},{"issue":"23","key":"2753_CR56","doi-asserted-by":"publisher","first-page":"e15989","DOI":"10.1097\/MD.0000000000015989","volume":"98","author":"ZM Yi","year":"2019","unstructured":"Yi ZM, Chen SD, Tang QY, Tang HL, Zhai SD (2019) Efficacy and safety of sertraline for the treatment of premature ejaculation: systematic review and meta-analysis. Medicine (Baltimore) 98(23):e15989. https:\/\/doi.org\/10.1097\/MD.0000000000015989","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"2753_CR57","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/cpt.337","volume":"100","author":"K Yoshida","year":"2016","unstructured":"Yoshida K, Sun B, Zhang L et al (2016) Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4\/5. Clin Pharmacol Ther 100(1):75\u201387. https:\/\/doi.org\/10.1002\/cpt.337","journal-title":"Clin Pharmacol Ther"},{"key":"2753_CR58","doi-asserted-by":"publisher","first-page":"8534","DOI":"10.1038\/srep08534","volume":"5","author":"D Yu","year":"2015","unstructured":"Yu D, Green B, Marrone A et al (2015a) Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. Sci Rep 5:8534. https:\/\/doi.org\/10.1038\/srep08534","journal-title":"Sci Rep"},{"issue":"1","key":"2753_CR59","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bcp.2015.08.094","volume":"98","author":"D Yu","year":"2015","unstructured":"Yu D, Green B, Tolleson WH et al (2015b) MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells. Biochem Pharmacol 98(1):215\u2013223. https:\/\/doi.org\/10.1016\/j.bcp.2015.08.094","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"2753_CR60","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s11096-016-0259-8","volume":"38","author":"N Yuce-Artun","year":"2016","unstructured":"Yuce-Artun N, Baskak B, Ozel-Kizil ET et al (2016) Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients. Int J Clin Pharm 38(2):388\u2013394. https:\/\/doi.org\/10.1007\/s11096-016-0259-8","journal-title":"Int J Clin Pharm"},{"key":"2753_CR61","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.bcp.2017.05.018","volume":"140","author":"L Zeng","year":"2017","unstructured":"Zeng L, Chen Y, Wang Y et al (2017) MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation. Biochem Pharmacol 140:139\u2013149. https:\/\/doi.org\/10.1016\/j.bcp.2017.05.018","journal-title":"Biochem Pharmacol"},{"key":"2753_CR62","doi-asserted-by":"publisher","first-page":"14633","DOI":"10.1038\/srep14633","volume":"5","author":"Z Zhang","year":"2015","unstructured":"Zhang Z, Chen S, Mei H et al (2015) Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. Sci Rep 5:14633. https:\/\/doi.org\/10.1038\/srep14633","journal-title":"Sci Rep"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-020-02753-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-020-02753-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-020-02753-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T23:10:05Z","timestamp":1620169805000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-020-02753-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2753"],"URL":"https:\/\/doi.org\/10.1007\/s00204-020-02753-y","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"assertion":[{"value":"16 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}