{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:50:10Z","timestamp":1770814210415,"version":"3.50.1"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00204-021-03105-0","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T03:24:02Z","timestamp":1627615442000},"page":"2941-2959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of pregnancy and non-fasting conditions on the plasma metabolome in a rat prenatal toxicity study"],"prefix":"10.1007","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-7061","authenticated-orcid":false,"given":"S.","family":"Ramirez-Hincapie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Giri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Haake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Richling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"van Ravenzwaay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"issue":"3","key":"3105_CR1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/dmr.5610050302","volume":"5","author":"NN Abumrad","year":"1989","unstructured":"Abumrad NN, Williams P, Frexes-Steed M, Geer R, Flakoll P, Cersosimo E, Hourani H (1989) Inter-organ metabolism of amino acids in vivo. Diabetes Metab Rev 5(3):213\u2013226","journal-title":"Diabetes Metab Rev"},{"issue":"7","key":"3105_CR2","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1172\/JCI107335","volume":"52","author":"SA Adibi","year":"1973","unstructured":"Adibi SA, Mercer DW (1973) Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals. J Clin Investig 52(7):1586\u20131594","journal-title":"J Clin Investig"},{"issue":"5","key":"3105_CR3","first-page":"1003","volume":"74","author":"T Aikawa","year":"1973","unstructured":"Aikawa T, Matsutaka H, Yamamoto H, Okuda T, Ishikawa E, Kawano T, Matsumura E (1973) Gluconeogenesis and amino acid metabolism: II. Inter-organal relations and roles of glutamine and alanine in the amino acid metabolism of fasted rats. The Journal of Biochemistry 74(5):1003\u20131017","journal-title":"The Journal of Biochemistry"},{"issue":"12","key":"3105_CR4","doi-asserted-by":"publisher","first-page":"e82989","DOI":"10.1371\/journal.pone.0082989","volume":"8","author":"G Altobelli","year":"2013","unstructured":"Altobelli G, Bogdarina IG, Stupka E, Clark AJ, Langley-Evans S (2013) Genome-wide methylation and gene expression changes in newborn rats following maternal protein restriction and reversal by folic acid. PLoS ONE 8(12):e82989","journal-title":"PLoS ONE"},{"issue":"3","key":"3105_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1093\/glycob\/8.3.285","volume":"8","author":"G Alton","year":"1998","unstructured":"Alton G, Hasilik M, Niehues R, Panneerselvam K, Etchison JR, Fana F, Freeze HH (1998) Direct utilization of mannose for mammalian glycoprotein biosynthesis. Glycobiology 8(3):285\u2013295","journal-title":"Glycobiology"},{"issue":"2","key":"3105_CR6","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0022-2275(20)37617-3","volume":"37","author":"J Alvarez","year":"1996","unstructured":"Alvarez J, Montelongo A, Iglesias A, Lasuncion M, Herrera E (1996) Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J Lipid Res 37(2):299\u2013308","journal-title":"J Lipid Res"},{"key":"3105_CR7","doi-asserted-by":"crossref","unstructured":"Argil\u00e9s JM, Herrera Castill\u00f3n E (1981) Lipids and lipoproteins in maternal and fetus plama in the rat. Biol Neonate 39(1\u20132):37\u201344","DOI":"10.1159\/000241390"},{"issue":"3","key":"3105_CR8","doi-asserted-by":"publisher","first-page":"E351","DOI":"10.1152\/ajpendo.1993.265.3.E351","volume":"265","author":"B Assel","year":"1993","unstructured":"Assel B, Rossi K, Kalhan S (1993) Glucose metabolism during fasting through human pregnancy: comparison of tracer method with respiratory calorimetry. Am J Physiol-Endocrinol Metab 265(3):E351\u2013E356","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"1","key":"3105_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-15882-9","volume":"7","author":"R Bahado-Singh","year":"2017","unstructured":"Bahado-Singh R, Poon LC, Yilmaz A, Syngelaki A, Turkoglu O, Kumar P, Li J (2017) Integrated proteomic and metabolomic prediction of term preeclampsia. Sci Rep 7(1):1\u201310","journal-title":"Sci Rep"},{"issue":"3","key":"3105_CR10","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1177\/0269881108089583","volume":"23","author":"S Barry","year":"2009","unstructured":"Barry S, Clarke G, Scully P, Dinan T (2009) Kynurenine pathway in psychosis: evidence of increased tryptophan degradation. J Psychopharmacol 23(3):287\u2013294","journal-title":"J Psychopharmacol"},{"key":"3105_CR11","volume-title":"Endocrinology of pregnancy (Vol. 9)","author":"FW Bazer","year":"2012","unstructured":"Bazer FW (2012) Endocrinology of pregnancy (Vol. 9). Springer Science & Business Media"},{"issue":"10","key":"3105_CR12","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1007\/s00204-017-1949-2","volume":"91","author":"C Behr","year":"2017","unstructured":"Behr C, Kamp H, Fabian E, Krennrich G, Mellert W, Peter E, Van Ravenzwaay B (2017) Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats. Arch Toxicol 91(10):3439\u20133454","journal-title":"Arch Toxicol"},{"issue":"16","key":"3105_CR13","doi-asserted-by":"publisher","first-page":"9424","DOI":"10.1073\/pnas.95.16.9424","volume":"95","author":"S Berger","year":"1998","unstructured":"Berger S, Bleich M, Schmid W, Cole TJ, Peters J, Watanabe H, Sch\u00fctz G (1998) Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci 95(16):9424\u20139429","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"3105_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/0026-0495(73)90239-4","volume":"22","author":"PR Boulter","year":"1973","unstructured":"Boulter PR, Hoffman RS, Arky RA (1973) Pattern of sodium excretion accompanying starvation. Metabolism 22(5):675\u2013683","journal-title":"Metabolism"},{"issue":"2","key":"3105_CR15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1210\/jcem-38-2-248","volume":"38","author":"PR Boulter","year":"1974","unstructured":"Boulter PR, Spark RF, Arky RA (1974) Dissociation of the renin\u2013aldosterone system and refractoriness to the sodium-retaining action of mineralocorticoid during starvation in man. J Clin Endocrinol Metab 38(2):248\u2013254","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"3105_CR16","doi-asserted-by":"publisher","first-page":"E622","DOI":"10.1152\/ajpendo.1986.250.6.E622","volume":"250","author":"E Cersosimo","year":"1986","unstructured":"Cersosimo E, Williams P, Radosevich P, Hoxworth B, Lacy W, Abumrad N (1986) Role of glutamine in adaptations in nitrogen metabolism during fasting. Am J Physiol-Endocrinol Metab 250(6):E622\u2013E628","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"3","key":"3105_CR17","doi-asserted-by":"publisher","first-page":"E313","DOI":"10.1152\/ajpendo.1987.252.3.E313","volume":"252","author":"E Cersosimo","year":"1987","unstructured":"Cersosimo E, Williams PE, O\u2019Donovan D, Lacy DB, Abumrad NN (1987) Role of acidosis in regulating hepatic nitrogen metabolism during fasting in conscious dog. Am J Physiol-Endocrinol Metab 252(3):E313\u2013E319","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"5","key":"3105_CR18","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/S0002-9378(96)70609-9","volume":"174","author":"I Cetin","year":"1996","unstructured":"Cetin I, Ronzoni S, Marconi AM, Perugino G, Corbetta C, Battaglia FC, Pardi G (1996) Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies. Am J Obstet Gynecol 174(5):1575\u20131583","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"3105_CR19","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/0006-291X(78)91144-0","volume":"85","author":"J Chaves","year":"1978","unstructured":"Chaves J, Herrera E (1978) Invitro glycerol metabolism in adipose tissue from fasted pregnant rats. Biochem Biophys Res Commun 85(4):1299\u20131306","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"3105_CR20","doi-asserted-by":"publisher","first-page":"5307","DOI":"10.1038\/s41598-020-62131-7","volume":"10","author":"CM Clinton","year":"2020","unstructured":"Clinton CM, Bain JR, Muehlbauer MJ, Li Y, Li L, O\u2019Neal SK, Ferguson KK (2020) Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction. Sci Rep 10(1):5307. https:\/\/doi.org\/10.1038\/s41598-020-62131-7","journal-title":"Sci Rep"},{"key":"3105_CR153","doi-asserted-by":"crossref","unstructured":"Commission Regulation (EU) (2016) 2016\/266 of 7 December 2015 amending, for the purpose of its adaptation to technical progress, Regulation (EC) No 440\/2008 laying down test methods pursuant to Regulation (EC) No 1907\/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Commission Regulation (EU) 2016\/266","DOI":"10.1016\/j.fos.2016.03.026"},{"issue":"9","key":"3105_CR21","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0899-9007(02)00780-3","volume":"18","author":"LA Cynober","year":"2002","unstructured":"Cynober LA (2002) Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 18(9):761\u2013766","journal-title":"Nutrition"},{"issue":"6","key":"3105_CR22","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1080\/14767050410001725578","volume":"15","author":"A Di Giulio","year":"2004","unstructured":"Di Giulio A, Carelli S, Castoldi R, Gorio A, Taricco E, Cetin I (2004) Plasma amino acid concentrations throughout normal pregnancy and early stages of intrauterine growth restricted pregnancy. J Matern Fetal Neonatal Med 15(6):356\u2013362","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"8","key":"3105_CR23","doi-asserted-by":"publisher","first-page":"3732","DOI":"10.1021\/pr200352m","volume":"10","author":"SLO Diaz","year":"2011","unstructured":"Diaz SLO, Pinto J, Gra\u00e7a GA, Duarte IF, Barros ANS, Galhano EI, Carreira IM (2011) Metabolic biomarkers of prenatal disorders: an exploratory NMR metabonomics study of second trimester maternal urine and blood plasma. J Proteome Res 10(8):3732\u20133742","journal-title":"J Proteome Res"},{"issue":"2","key":"3105_CR24","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1021\/pr301022e","volume":"12","author":"SO Diaz","year":"2013","unstructured":"Diaz SO, Barros ANS, Goodfellow BJ, Duarte IF, Carreira IM, Galhano EI, Gil AM (2013) Following healthy pregnancy by nuclear magnetic resonance (NMR) metabolic profiling of human urine. J Proteome Res 12(2):969\u2013979","journal-title":"J Proteome Res"},{"issue":"1","key":"3105_CR25","first-page":"9","volume":"1","author":"W Doyle","year":"1990","unstructured":"Doyle W, Crawford M, Wynn A, Wynn S (1990) The association between maternal diet and birth dimensions. J Nutr Med 1(1):9\u201317","journal-title":"J Nutr Med"},{"key":"3105_CR26","doi-asserted-by":"crossref","unstructured":"ECETOC (2004) Influence of maternal toxicity in studies on developmental toxicity. ECETOC WORKSHOP REPORT No. 4. (Brussels), p, 1(43), 114\u2013115","DOI":"10.1016\/j.yrtph.2005.06.004"},{"issue":"4","key":"3105_CR27","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1053\/gast.2002.32539","volume":"122","author":"ER Eckhardt","year":"2002","unstructured":"Eckhardt ER, Wang DQH, Donovan JM, Carey MC (2002) Dietary sphingomyelin suppresses intestinal cholesterol absorption by decreasing thermodynamic activity of cholesterol monomers. Gastroenterology 122(4):948\u2013956","journal-title":"Gastroenterology"},{"issue":"2","key":"3105_CR28","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/pd.262","volume":"22","author":"A Farina","year":"2002","unstructured":"Farina A, Caramelli E, Concu M, Sekizawa A, Ruggeri R, Bovicelli L, Carinci P (2002) Testing normality of fetal DNA concentration in maternal plasma at 10\u201312 completed weeks\u2019 gestation: a preliminary approach to a new marker for genetic screening. Prenatal Diagn 22(2):148\u2013152","journal-title":"Prenatal Diagn"},{"issue":"2","key":"3105_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1042\/bj3600265","volume":"360","author":"RP Ferraris","year":"2001","unstructured":"Ferraris RP (2001) Dietary and developmental regulation of intestinal sugar transport. Biochem J 360(2):265\u2013276","journal-title":"Biochem J"},{"issue":"5","key":"3105_CR30","doi-asserted-by":"publisher","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","volume":"5","author":"WE Gall","year":"2010","unstructured":"Gall WE, Beebe K, Lawton KA, Adam K-P, Mitchell MW, Nakhle PJ, Camastra S (2010) \u03b1-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS ONE 5(5):e10883","journal-title":"PLoS ONE"},{"issue":"3","key":"3105_CR31","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.yrtph.2011.11.021","volume":"62","author":"E Giavini","year":"2012","unstructured":"Giavini E, Menegola E (2012) The problem of maternal toxicity in developmental toxicity studies. Regul Toxicol Pharmacol 62(3):568\u2013570. https:\/\/doi.org\/10.1016\/j.yrtph.2011.11.021","journal-title":"Regul Toxicol Pharmacol"},{"issue":"11","key":"3105_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224682","volume":"14","author":"SK Handelman","year":"2019","unstructured":"Handelman SK, Romero R, Tarca AL, Pacora P, Ingram B, Maymon E, Erez O (2019) The plasma metabolome of women in early pregnancy differs from that of non-pregnant women. PLoS ONE 14(11):e0224682. https:\/\/doi.org\/10.1371\/journal.pone.0224682","journal-title":"PLoS ONE"},{"key":"3105_CR33","unstructured":"Hastie T, Tibshirani R, Narasimhan B, Chu G (2020) Impute: impute: Imputation for microarray data. R package version 1.54. 0"},{"issue":"3","key":"3105_CR34","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1203\/00006450-198603000-00015","volume":"20","author":"S Hauguel","year":"1986","unstructured":"Hauguel S, Desmaizieres V, Challier J (1986) Glucose uptake, utilization, and transfer by the human placenta as functions of maternal glucose concentration. Pediatr Res 20(3):269\u2013273","journal-title":"Pediatr Res"},{"issue":"2","key":"3105_CR35","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.1152\/ajpendo.1978.234.2.E197","volume":"234","author":"R Heitmann","year":"1978","unstructured":"Heitmann R, Bergman E (1978) Glutamine metabolism, interorgan transport and glucogenicity in the sheep. Am J Physiol-Endocrinol Metab 234(2):E197","journal-title":"Am J Physiol-Endocrinol Metab"},{"issue":"1","key":"3105_CR36","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1038\/sj.ejcn.1600984","volume":"54","author":"E Herrera","year":"2000","unstructured":"Herrera E (2000) Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr 54(1):S47\u2013S51","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"3105_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1385\/ENDO:19:1:43","volume":"19","author":"E Herrera","year":"2002","unstructured":"Herrera E (2002) Lipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine 19(1):43\u201355","journal-title":"Endocrine"},{"issue":"12","key":"3105_CR38","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1172\/JCI106192","volume":"48","author":"E Herrera","year":"1969","unstructured":"Herrera E, Knopp RH, Freinkel N (1969) Carbohydrate metabolism in pregnancy: VI. Plasma fuels, insulin, liver composition, gluconeogenesis, and nitrogen metabolism during late gestation in the fed and fasted rat. J Clin Investig 48(12):2260\u20132272","journal-title":"J Clin Investig"},{"issue":"Supplement 2","key":"3105_CR39","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2337\/diab.34.2.S42","volume":"34","author":"E Herrera","year":"1985","unstructured":"Herrera E, Palacin M, Martin A, Lasuncion MA (1985) Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity. Diabetes 34(Supplement 2):42\u201346","journal-title":"Diabetes"},{"key":"3105_CR40","unstructured":"Herrera E, Ramos P, Lopez-Luna P, Lasuncion M (1994) Metabolic interactions during pregnancy in preparation for lactation. In: Serrano Rios M, Sastre A, Perez Juez MA, Entrala A, De Sabesti C (eds) Dairy products in human health and nutrition. Balkema, Rotterdam, pp 189\u2013197. ISBN 90 5410 359 0"},{"issue":"Suppl. 3","key":"3105_CR41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000091507","volume":"65","author":"E Herrera","year":"2006","unstructured":"Herrera E, Amusquivar E, Lopez-Soldado I, Ortega H (2006) Maternal lipid metabolism and placental lipid transfer. Hormone Res Paediatr 65(Suppl. 3):59\u201364","journal-title":"Hormone Res Paediatr"},{"issue":"4","key":"3105_CR43","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nm.4057","volume":"22","author":"C Jang","year":"2016","unstructured":"Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Ibrahim A (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med 22(4):421\u2013426","journal-title":"Nat Med"},{"issue":"7","key":"3105_CR44","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1172\/JCI119704","volume":"100","author":"S Kalhan","year":"1997","unstructured":"Kalhan S, Rossi K, Gruca L, Burkett E, O\u2019Brien A (1997) Glucose turnover and gluconeogenesis in human pregnancy. J Clin Investig 100(7):1775\u20131781","journal-title":"J Clin Investig"},{"issue":"2","key":"3105_CR45","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1373\/clinchem.2013.211979","volume":"60","author":"B Kamlage","year":"2014","unstructured":"Kamlage B, Maldonado SG, Bethan B, Peter E, Schmitz O, Liebenberg V, Schatz P (2014) Quality markers addressing preanalytical variations of blood and plasma processing identified by broad and targeted metabolite profiling. Clin Chem 60(2):399\u2013412","journal-title":"Clin Chem"},{"issue":"2","key":"3105_CR46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.toxlet.2012.09.015","volume":"215","author":"H Kamp","year":"2012","unstructured":"Kamp H, Strauss V, Wiemer J, Leibold E, Walk T, Mellert W, Krennrich G (2012) Reproducibility and robustness of metabolome analysis in rat plasma of 28-day repeated dose toxicity studies. Toxicol Lett 215(2):143\u2013149","journal-title":"Toxicol Lett"},{"key":"3105_CR47","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.toxlet.2018.10.032","volume":"301","author":"J Keller","year":"2019","unstructured":"Keller J, Mellert W, Sperber S, Kamp H, Jiang X, Fabian E, van Ravenzwaay B (2019) Added value of plasma metabolomics to describe maternal effects in rat maternal and prenatal toxicity studies. Toxicol Lett 301:42\u201352. https:\/\/doi.org\/10.1016\/j.toxlet.2018.10.032","journal-title":"Toxicol Lett"},{"key":"3105_CR48","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/tera.1420290312","volume":"29","author":"KS Khera","year":"1984","unstructured":"Khera KS (1984) Maternal toxicity\u2014a possible factor in fetal malformations in mice. Teratology 29:411\u2013416","journal-title":"Teratology"},{"key":"3105_CR49","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/tcm.1770070309","volume":"7","author":"KS Khera","year":"1987","unstructured":"Khera KS (1987) Maternal toxicity in humans and animals: effects on fetal development and criteria for detection. Teratog Carcinog Mutagen 7:287\u2013295","journal-title":"Teratog Carcinog Mutagen"},{"issue":"12","key":"3105_CR50","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1007\/BF01990104","volume":"39","author":"G Kim","year":"1983","unstructured":"Kim G, Chevli K, Fitch C (1983) Fasting modulates creatine entry-into skeletal muscle in the mouse. Experientia 39(12):1360\u20131362","journal-title":"Experientia"},{"issue":"1","key":"3105_CR51","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00003081-198103000-00006","volume":"24","author":"RH Knopp","year":"1981","unstructured":"Knopp RH, MontesChildsLiMabuchi AMJRH (1981) Metabolic adjustments in normal and diabetic pregnancy. Clin Obstet Gynecol 24(1):21\u201349","journal-title":"Clin Obstet Gynecol"},{"issue":"6","key":"3105_CR52","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3109\/00365516609049049","volume":"18","author":"B Kuhlb\u00e4uck","year":"1966","unstructured":"Kuhlb\u00e4uck B, Widholm O (1966) Plasma creatinine in normal pregnancy. Scand J Clin Lab Invest 18(6):654\u2013656","journal-title":"Scand J Clin Lab Invest"},{"issue":"13","key":"3105_CR53","doi-asserted-by":"publisher","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","volume":"96","author":"TC Leone","year":"1999","unstructured":"Leone TC, Weinheimer CJ, Kelly DP (1999) A critical role for the peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1) in the cellular fasting response: the PPAR\u03b1-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci 96(13):7473\u20137478","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"3105_CR54","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00726-017-2490-6","volume":"50","author":"P Li","year":"2018","unstructured":"Li P, Wu G (2018) Roles of dietary glycine, proline, and hydroxyproline in collagen synthesis and animal growth. Amino Acids 50(1):29\u201338","journal-title":"Amino Acids"},{"issue":"45","key":"3105_CR55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pnmrs.2004.05.001","volume":"1","author":"JC Lindon","year":"2004","unstructured":"Lindon JC, Holmes E, Nicholson JK (2004) Toxicological applications of magnetic resonance. Prog Nucl Magn Reson Spectrosc 1(45):109\u2013143","journal-title":"Prog Nucl Magn Reson Spectrosc"},{"issue":"6","key":"3105_CR56","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s11095-006-0025-z","volume":"23","author":"JC Lindon","year":"2006","unstructured":"Lindon JC, Holmes E, Nicholson JK (2006) Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res 23(6):1075\u20131088","journal-title":"Pharm Res"},{"issue":"3\u20134","key":"3105_CR57","first-page":"173","volume":"53","author":"G Lippi","year":"2007","unstructured":"Lippi G, Albiero A, Montagnana M, Salvagno GL, Scevarolli S, Franchi M, Guidi GC (2007) Lipid and lipoprotein profile in physiological pregnancy. Clin Lab 53(3\u20134):173\u2013178","journal-title":"Clin Lab"},{"issue":"4","key":"3105_CR58","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1086\/301800","volume":"62","author":"YD Lo","year":"1998","unstructured":"Lo YD, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, Hjelm NM (1998) Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet 62(4):768\u2013775","journal-title":"Am J Hum Genet"},{"issue":"3","key":"3105_CR59","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1021\/pr401068k","volume":"13","author":"H Luan","year":"2014","unstructured":"Luan H, Meng N, Liu P, Feng Q, Lin S, Fu J, Chen F (2014) Pregnancy-induced metabolic phenotype variations in maternal plasma. J Proteome Res 13(3):1527\u20131536","journal-title":"J Proteome Res"},{"issue":"10","key":"3105_CR60","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1373\/clinchem.2008.111385","volume":"54","author":"FM Lun","year":"2008","unstructured":"Lun FM, Chiu RW, Allen Chan K, Yeung Leung T, Kin Lau T, Dennis Lo Y (2008) Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma. Clin Chem 54(10):1664\u20131672","journal-title":"Clin Chem"},{"issue":"3","key":"3105_CR61","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1042\/bj2390773","volume":"239","author":"P Lund","year":"1986","unstructured":"Lund P, Wiggins D (1986) The ornithine requirement of urea synthesis. Formation of ornithine from glutamine in hepatocytes. Biochem J 239(3):773\u2013776","journal-title":"Biochem J"},{"issue":"3","key":"3105_CR62","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.mpaic.2018.01.001","volume":"19","author":"NG MacFarlane","year":"2018","unstructured":"MacFarlane NG (2018) Digestion and absorption. Anaesth Intensive Care Med 19(3):125\u2013127","journal-title":"Anaesth Intensive Care Med"},{"issue":"16","key":"3105_CR63","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1016\/S0024-3205(02)01853-2","volume":"71","author":"M Maes","year":"2002","unstructured":"Maes M, Verkerk R, Bonaccorso S, Ombelet W, Bosmans E, Scharp\u00e9 S (2002) Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. Life Sci 71(16):1837\u20131848","journal-title":"Life Sci"},{"issue":"8","key":"3105_CR64","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1001\/archinte.1984.00350200067009","volume":"144","author":"SR Mascioli","year":"1984","unstructured":"Mascioli SR, Bantle JP, Freier EF, Hoogwerf BJ (1984) Artifactual elevation of serum creatinine level due to fasting. Arch Intern Med 144(8):1575\u20131576","journal-title":"Arch Intern Med"},{"key":"3105_CR65","doi-asserted-by":"crossref","unstructured":"Mattes W, Kamp H, Fabian E, Herold M, Krennrich G, Looser R, van Ravenzwaay B (2013) Prediction of clinically relevant safety signals of nephrotoxicity through plasma metabolite profiling. BioMed Res Int 2013:202497","DOI":"10.1155\/2013\/202497"},{"issue":"3","key":"3105_CR66","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.toxlet.2014.07.021","volume":"230","author":"W Mattes","year":"2014","unstructured":"Mattes W, Davis K, Fabian E, Greenhaw J, Herold M, Looser R, Moeller N (2014) Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicol Lett 230(3):467\u2013478","journal-title":"Toxicol Lett"},{"issue":"2","key":"3105_CR67","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.toxlet.2011.08.013","volume":"207","author":"W Mellert","year":"2011","unstructured":"Mellert W, Kapp M, Strauss V, Wiemer J, Kamp H, Walk T, van Ravenzwaay B (2011) Nutritional impact on the plasma metabolome of rats. Toxicol Lett 207(2):173\u2013181. https:\/\/doi.org\/10.1016\/j.toxlet.2011.08.013","journal-title":"Toxicol Lett"},{"issue":"3","key":"3105_CR68","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1017\/S0007114500000386","volume":"83","author":"G Milano","year":"2000","unstructured":"Milano G, Hotston-Moore A, Lobley G (2000) Influence of hepatic ammonia removal on ureagenesis, amino acid utilization and energy metabolism in the ovine liver. Br J Nutr 83(3):307\u2013315","journal-title":"Br J Nutr"},{"issue":"2","key":"3105_CR69","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.toxlet.2013.12.010","volume":"225","author":"G Montoya","year":"2014","unstructured":"Montoya G, Strauss V, Fabian E, Kamp H, Mellert W, Walk T, Peter E (2014) Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicol Lett 225(2):240\u2013251","journal-title":"Toxicol Lett"},{"issue":"2","key":"3105_CR70","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/0003-9861(89)90395-0","volume":"275","author":"PS Moore","year":"1989","unstructured":"Moore PS, Koontz JW (1989) Insulin-mediated regulation of tyrosine aminotransferase in rat hepatoma cells: inhibition of transcription and inhibition of enzyme degradation. Arch Biochem Biophys 275(2):486\u2013495","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"3105_CR71","first-page":"218","volume":"8","author":"BF Nicolosi","year":"2019","unstructured":"Nicolosi BF, Leite DF, Mayrink J, Souza RT, Cecatti JG, Calderon IDMP (2019) Metabolomics for predicting hyperglycemia in pregnancy: a protocol for a systematic review and potential meta-analysis. Syst Control Found Appl 8(1):218","journal-title":"Syst Control Found Appl"},{"issue":"10","key":"3105_CR72","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/ejlt.200600250","volume":"109","author":"WF Nieuwenhuizen","year":"2007","unstructured":"Nieuwenhuizen WF, Duivenvoorden I, Voshol PJ, Rensen PC, van Duyvenvoorde W, Romijn JA, Havekes LM (2007) Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis. Eur J Lipid Sci Technol 109(10):994\u2013997","journal-title":"Eur J Lipid Sci Technol"},{"issue":"11","key":"3105_CR73","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3390\/nu9111180","volume":"9","author":"GH Norris","year":"2017","unstructured":"Norris GH, Blesso CN (2017) Dietary and endogenous sphingolipid metabolism in chronic inflammation. Nutrients 9(11):1180","journal-title":"Nutrients"},{"key":"3105_CR74","first-page":"1569","volume":"2","author":"M Numan","year":"1988","unstructured":"Numan M (1988) Maternal behavior. Physiol Reprod 2:1569\u20131645","journal-title":"Physiol Reprod"},{"key":"3105_CR150","unstructured":"OECD (1992) Decision of the council concerning the mutual acceptance of data in the assessment of chemicals (C(81)30(Final)). Adopted by the council at its 535th meeting on 12 May 1981"},{"key":"3105_CR151","unstructured":"OECD (2001) Test No. 414: prenatal development toxicity study. OECD Publishing, Paris"},{"key":"3105_CR75","doi-asserted-by":"publisher","DOI":"10.1787\/9789264070820-en","volume-title":"OECD 414 OECD Guideline for testing of chemicals: Prenatal developmental toxicity study","author":"OECD","year":"2018","unstructured":"OECD (2018) OECD 414 OECD Guideline for testing of chemicals: Prenatal developmental toxicity study. OECD"},{"issue":"5","key":"3105_CR76","doi-asserted-by":"publisher","first-page":"e201301004","DOI":"10.5936\/csbj.201301004","volume":"4","author":"A O'Gorman","year":"2013","unstructured":"O\u2019Gorman A, Gibbons H, Brennan L (2013) Metabolomics in the identification of biomarkers of dietary intake. Comput Struct Biotechnol J 4(5):e201301004","journal-title":"Comput Struct Biotechnol J"},{"issue":"3","key":"3105_CR77","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1172\/JCI106016","volume":"48","author":"OE Owen","year":"1969","unstructured":"Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF (1969) Liver and kidney metabolism during prolonged starvation. J Clin Investig 48(3):574\u2013583","journal-title":"J Clin Investig"},{"issue":"1","key":"3105_CR78","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000077011","volume":"58","author":"PR Palan","year":"2004","unstructured":"Palan PR, Shaban DW, Martino T, Mikhail MS (2004) Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, \u03b1-tocopherol and \u03b3-tocopherol in preeclampsia and normal pregnancy. Gynecol Obstet Invest 58(1):8\u201313","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"3105_CR79","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1021\/pr5011982","volume":"14","author":"J Pinto","year":"2015","unstructured":"Pinto J, Barros ANS, Domingues MRRM, Goodfellow BJ, Galhano EI, Pita C, Gil AM (2015) Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine. J Proteome Res 14(2):1263\u20131274","journal-title":"J Proteome Res"},{"issue":"3","key":"3105_CR80","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0960-0760(94)00175-L","volume":"52","author":"M Pulkkinen","year":"1995","unstructured":"Pulkkinen M, H\u00e4m\u00e4l\u00e4inen MM (1995) Myometrial estrogen and progesterone receptor binding in pregnancy: inhibition by the detergent action of phospholipids. J Steroid Biochem Mol Biol 52(3):287\u2013294","journal-title":"J Steroid Biochem Mol Biol"},{"key":"3105_CR81","unstructured":"RCore T (2016) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria"},{"key":"3105_CR152","doi-asserted-by":"publisher","unstructured":"Roessner U, Wagner C, Kopka J, Trethewey RN, Willmitzer L (2000) Technical advance: simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J 23:131\u2013142. https:\/\/doi.org\/10.1046\/j.1365-313x.2000.00774.x","DOI":"10.1046\/j.1365-313x.2000.00774.x"},{"issue":"1","key":"3105_CR82","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/00006254-199401000-00027","volume":"49","author":"EA Reece","year":"1994","unstructured":"Reece EA, Homko C, Wiznitzer A (1994) Metabolic changes in diabetic and nondiabetic subjects during pregnancy. Obstet Gynecol Surv 49(1):64\u201371","journal-title":"Obstet Gynecol Surv"},{"issue":"2","key":"3105_CR83","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.taap.2005.03.026","volume":"207","author":"JM Rogers","year":"2005","unstructured":"Rogers JM, Chernoff N, Keen CL, Daston GP (2005) Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs. Toxicol Appl Pharmacol 207(2):367\u2013374","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6","key":"3105_CR84","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1681\/ASN.2006090975","volume":"18","author":"C Ronzaud","year":"2007","unstructured":"Ronzaud C, Loffing J, Bleich M, Gretz N, Gr\u00f6ne H-J, Sch\u00fctz G, Berger S (2007) Impairment of sodium balance in mice deficient in renal principal cell mineralocorticoid receptor. J Am Soc Nephrol 18(6):1679\u20131687","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"3105_CR85","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s11306-010-0255-2","volume":"7","author":"I Rubio-Aliaga","year":"2011","unstructured":"Rubio-Aliaga I, de Roos B, Duthie SJ, Crosley LK, Mayer C, Horgan G, Kremer W (2011) Metabolomics of prolonged fasting in humans reveals new catabolic markers. Metabolomics 7(3):375\u2013387","journal-title":"Metabolomics"},{"issue":"5","key":"3105_CR86","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/jn\/124.5.702","volume":"124","author":"E-M Schmelz","year":"1994","unstructured":"Schmelz E-M, Crall KJ, Larocque R, Dillehay DL, Merrill AH Jr (1994) Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J Nutr 124(5):702\u2013712","journal-title":"J Nutr"},{"issue":"3","key":"3105_CR87","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/ejcn.2015.144","volume":"70","author":"JA Schmidt","year":"2016","unstructured":"Schmidt JA, Rinaldi S, Scalbert A, Ferrari P, Achaintre D, Gunter MJ, Travis RC (2016) Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr 70(3):306\u2013312","journal-title":"Eur J Clin Nutr"},{"key":"3105_CR88","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.mce.2016.01.003","volume":"423","author":"G Shen","year":"2016","unstructured":"Shen G, Li Z, Zhang Y, Wu H, Feng J (2016) 1H NMR-based metabolomics study on the physiological variations during the rat pregnancy process. Mol Cell Endocrinol 423:40\u201350","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"3105_CR89","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1172\/JCI103769","volume":"37","author":"EA Sims","year":"1958","unstructured":"Sims EA, Krantz KE (1958) Serial studies of renal function during pregnancy and the puerperium in normal women. J Clin Investig 37(12):1764\u20131774","journal-title":"J Clin Investig"},{"issue":"2","key":"3105_CR90","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/BF00926514","volume":"135","author":"MM Sola","year":"1994","unstructured":"Sola MM, Oliver FJ, Salto R, Guti\u00e9rrez M, Vargas A (1994) Citrate inhibition of rat-kidney cortex phosphofructokinase. Mol Cell Biochem 135(2):123\u2013128","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"3105_CR91","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.toxlet.2009.08.004","volume":"191","author":"V Strauss","year":"2009","unstructured":"Strauss V, Wiemer J, Leibold E, Kamp H, Walk T, Mellert W, Krennrich G (2009) Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies. Toxicol Lett 191(1):88\u201395","journal-title":"Toxicol Lett"},{"key":"3105_CR92","volume-title":"RStudio: integrated development environment","author":"R Team","year":"2015","unstructured":"Team R (2015) RStudio: integrated development environment. RStudio, PBC, Boston"},{"issue":"1","key":"3105_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-36674-9","volume":"9","author":"T Teruya","year":"2019","unstructured":"Teruya T, Chaleckis R, Takada J, Yanagida M, Kondoh H (2019) Diverse metabolic reactions activated during 58-hr fasting are revealed by non-targeted metabolomic analysis of human blood. Sci Rep 9(1):1\u201311","journal-title":"Sci Rep"},{"issue":"5","key":"3105_CR94","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1158\/1055-9965.EPI-15-1206","volume":"25","author":"MK Townsend","year":"2016","unstructured":"Townsend MK, Bao Y, Poole EM, Bertrand KA, Kraft P, Wolpin BM, Tworoger SS (2016) Impact of pre-analytic blood sample collection factors on metabolomics. Cancer Epidemiol Prev Biomark 25(5):823\u2013829","journal-title":"Cancer Epidemiol Prev Biomark"},{"issue":"1\u20132","key":"3105_CR95","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.toxlet.2007.05.021","volume":"172","author":"B Van Ravenzwaay","year":"2007","unstructured":"Van Ravenzwaay B, Cunha GC-P, Leibold E, Looser R, Mellert W, Prokoudine A, Wiemer J (2007) The use of metabolomics for the discovery of new biomarkers of effect. Toxicol Lett 172(1\u20132):21\u201328","journal-title":"Toxicol Lett"},{"key":"3105_CR96","doi-asserted-by":"publisher","unstructured":"Van Ravenzwaay B, Cunha G, Fabian E, Herold M, Kamp H, Krennrich G, Mellert W (2010a) The Use of metabolomics in cancer research. In: Cho W (ed) An omics perspective on cancer research. Springer, Dordrecht. https:\/\/doi.org\/10.1007\/978-90-481-2675-0_8","DOI":"10.1007\/978-90-481-2675-0_8"},{"issue":"2","key":"3105_CR97","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.toxlet.2010.06.009","volume":"198","author":"B Van Ravenzwaay","year":"2010","unstructured":"Van Ravenzwaay B, Cunha G, Strauss V, Wiemer J, Leibold E, Kamp H, Prokoudine A (2010b) The individual and combined metabolite profiles (metabolomics) of dibutylphthalate and di (2-ethylhexyl) phthalate following a 28-day dietary exposure in rats. Toxicol Lett 198(2):159\u2013170","journal-title":"Toxicol Lett"},{"issue":"2","key":"3105_CR98","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.mrgentox.2012.01.006","volume":"746","author":"B Van Ravenzwaay","year":"2012","unstructured":"Van Ravenzwaay B, Herold M, Kamp H, Kapp M, Fabian E, Looser R, Strauss V (2012) Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals\u2014from QSAR to QBAR. Mutation Research\/genet Toxicol Environ Mutagen 746(2):144\u2013150","journal-title":"Mutation Research\/genet Toxicol Environ Mutagen"},{"issue":"1","key":"3105_CR99","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1504\/IJBT.2015.074801","volume":"14","author":"B Van Ravenzwaay","year":"2015","unstructured":"Van Ravenzwaay B, Kamp H, Montoya-Parra G, Strauss V, Fabian E, Mellert W, Looser R (2015) The development of a database for metabolomics\u2013looking back on ten years of experience. Int J Biotechnol 14(1):47\u201368","journal-title":"Int J Biotechnol"},{"issue":"3","key":"3105_CR100","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.toxlet.2013.03.029","volume":"223","author":"B van Ravenzwaay","year":"2013","unstructured":"van Ravenzwaay B, Kolle S, Ramirez T, Kamp H (2013) Vinclozolin: a case study on the identification of endocrine active substances in the past and a future perspective. Toxicol Lett 223(3):271\u2013279","journal-title":"Toxicol Lett"},{"issue":"1","key":"3105_CR101","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.toxlet.2014.03.004","volume":"227","author":"B van Ravenzwaay","year":"2014","unstructured":"van Ravenzwaay B, Montoya GA, Fabian E, Herold M, Krennrich G, Looser R, Kamp H (2014) The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective. Toxicol Lett 227(1):20\u201328. https:\/\/doi.org\/10.1016\/j.toxlet.2014.03.004","journal-title":"Toxicol Lett"},{"issue":"22","key":"3105_CR102","doi-asserted-by":"publisher","first-page":"12102","DOI":"10.1021\/jf203428t","volume":"59","author":"C Venegas","year":"2011","unstructured":"Venegas C, Cabrera-Vique C, Garc\u00eda-Corzo L, Escames G, Acu\u00f1a-Castroviejo D, L\u00f3pez LC (2011) Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. J Agric Food Chem 59(22):12102\u201312108","journal-title":"J Agric Food Chem"},{"key":"3105_CR103","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0065-2571(63)90015-3","volume":"1","author":"JB Walker","year":"1963","unstructured":"Walker JB (1963) End-product repression in the creatine pathway of the developing chick embryo. Adv Enzyme Regul 1:151\u2013168","journal-title":"Adv Enzyme Regul"},{"issue":"1","key":"3105_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-016-0733-0","volume":"14","author":"Q Wang","year":"2016","unstructured":"Wang Q, W\u00fcrtz P, Auro K, M\u00e4kinen V-P, Kangas AJ, Soininen P, Santalahti K (2016) Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med 14(1):1\u201314","journal-title":"BMC Med"},{"key":"3105_CR105","doi-asserted-by":"crossref","unstructured":"Wang M, Xia W, Li H, Liu F, Li,Y, Sun X, Xu S (2018) Normal pregnancy induced glucose metabolic stress in a longitudinal cohort of healthy women: novel insights generated from a urine metabolomics study. Medicine 97(40):e12417","DOI":"10.1097\/MD.0000000000012417"},{"issue":"1","key":"3105_CR106","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/cphy.c120010","volume":"3","author":"ID Weiner","year":"2013","unstructured":"Weiner ID, Verlander JW (2013) Renal ammonia metabolism and transport. Compr Physiol 3(1):201\u2013220","journal-title":"Compr Physiol"},{"issue":"5","key":"3105_CR107","doi-asserted-by":"publisher","first-page":"R859","DOI":"10.1152\/ajpregu.1986.251.5.R859","volume":"251","author":"T Welbourne","year":"1986","unstructured":"Welbourne T, Childress D, Givens G (1986) Renal regulation of interorgan glutamine flow in metabolic acidosis. Am J Physiol-Regul Integr Comp Physiol 251(5):R859\u2013R866","journal-title":"Am J Physiol-Regul Integr Comp Physiol"},{"key":"3105_CR108","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: elegant graphics for data analysis","author":"H Wickham","year":"2016","unstructured":"Wickham H (2016) ggplot2: elegant graphics for data analysis. Springer"},{"issue":"1","key":"3105_CR109","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/jat\/26.1.17","volume":"26","author":"H Yamada","year":"2002","unstructured":"Yamada H, Yamahara A, Yasuda S, Abe M, Oguri K, Fukushima S, Ikeda-Wada S (2002) Dansyl chloride derivatization of methamphetamine: a method with advantages for screening and analysis of methamphetamine in urine. J Anal Toxicol 26(1):17\u201322","journal-title":"J Anal Toxicol"},{"issue":"11","key":"3105_CR110","doi-asserted-by":"publisher","first-page":"7030","DOI":"10.1021\/jf100722f","volume":"58","author":"K Yunoki","year":"2010","unstructured":"Yunoki K, Renaguli M, Kinoshita M, Matsuyama H, Mawatari S, Fujino T, Ohnishi M (2010) Dietary sphingolipids ameliorate disorders of lipid metabolism in Zucker fatty rats. J Agric Food Chem 58(11):7030\u20137035","journal-title":"J Agric Food Chem"},{"issue":"20","key":"3105_CR111","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.1002\/rcm.5208","volume":"25","author":"F Zhang","year":"2011","unstructured":"Zhang F, Rick D, Kan L, Perala A, Geter D, LeBaron M, Bartels M (2011) Simultaneous quantitation of testosterone and estradiol in human cell line (H295R) by liquid chromatography\/positive atmospheric pressure photoionization tandem mass spectrometry. Rapid Commun Mass Spectrom 25(20):3123\u20133130","journal-title":"Rapid Commun Mass Spectrom"},{"key":"3105_CR112","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1462-P","volume-title":"Plasma metabolomics reveal novel metabolites in early pregnancy in association with gestational diabetes risk","author":"C Zhang","year":"2018","unstructured":"Zhang C, Feng Y-CA, Fiehn O, Tsai MY, Zhu Y, Albert P, Liang L (2018) Plasma metabolomics reveal novel metabolites in early pregnancy in association with gestational diabetes risk. Am Diabetes Assoc"},{"issue":"9","key":"3105_CR113","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.1096\/fj.201700614R","volume":"32","author":"X Zheng","year":"2018","unstructured":"Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Hernandez B (2018) Food withdrawal alters the gut microbiota and metabolome in mice. FASEB J 32(9):4878\u20134888","journal-title":"FASEB J"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03105-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-021-03105-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03105-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T17:04:13Z","timestamp":1629565453000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-021-03105-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":116,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["3105"],"URL":"https:\/\/doi.org\/10.1007\/s00204-021-03105-0","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]},"assertion":[{"value":"4 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author(s) declare(s) that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/Competing interests"}},{"value":"All ethics approvals are included in the methods section of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors have approved the manuscript and agree with its submission.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and Consent for publication"}}]}}