{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:09:47Z","timestamp":1793056187554,"version":"4.5.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000062","name":"national institute of diabetes and digestive and kidney diseases","doi-asserted-by":"publisher","award":["DK102142"],"award-info":[{"award-number":["DK102142"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"national institute of diabetes and digestive and kidney diseases","doi-asserted-by":"publisher","award":["DK125465"],"award-info":[{"award-number":["DK125465"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"national institute of general medical sciences","doi-asserted-by":"publisher","award":["GM103549"],"award-info":[{"award-number":["GM103549"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"national institute of general medical sciences","doi-asserted-by":"publisher","award":["GM118247"],"award-info":[{"award-number":["GM118247"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00204-021-03183-0","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T08:02:51Z","timestamp":1635753771000},"page":"305-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice"],"prefix":"10.1007","volume":"96","author":[{"given":"Nga T.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Umbaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Sanchez-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6980","authenticated-orcid":false,"given":"Hartmut","family":"Jaeschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"3183_CR1","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.4049\/jimmunol.165.9.5269","volume":"165","author":"CL Addison","year":"2000","unstructured":"Addison CL, Daniel TO, Burdick MD, Liu H, Ehlert JE, Xue YY, Buechi L, Walz A, Richmond A, Strieter RM (2000) The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 165:5269\u20135277","journal-title":"J Immunol"},{"key":"3183_CR2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ajpath.2010.11.026","volume":"178","author":"K Allen","year":"2011","unstructured":"Allen K, Jaeschke H, Copple BL (2011) Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178:175\u2013186","journal-title":"Am J Pathol"},{"key":"3183_CR3","doi-asserted-by":"publisher","first-page":"G1188","DOI":"10.1152\/ajpgi.2001.281.5.G1188","volume":"281","author":"ML Bajt","year":"2001","unstructured":"Bajt ML, Farhood A, Jaeschke H (2001) Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature. Am J Physiol Gastrointest Liver Physiol 281:G1188\u2013G1195","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3183_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/toxsci\/kfh151","volume":"80","author":"ML Bajt","year":"2004","unstructured":"Bajt ML, Knight TR, Lemasters JJ, Jaeschke H (2004) Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci 80:343\u2013349","journal-title":"Toxicol Sci"},{"key":"3183_CR5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/toxsci\/kfl077","volume":"94","author":"ML Bajt","year":"2006","unstructured":"Bajt ML, Cover C, Lemasters JJ, Jaeschke H (2006) Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 94:217\u2013225","journal-title":"Toxicol Sci"},{"key":"3183_CR6","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/s42255-019-0109-9","volume":"1","author":"S Ben-Moshe","year":"2019","unstructured":"Ben-Moshe S, Shapira Y, Moor AE, Manco R, Veg T, Bahar Halpern K, Itzkovitz S (2019) Spatial sorting enables comprehensive characterization of liver zonation. Nat Metab 1:899\u2013911","journal-title":"Nat Metab"},{"key":"3183_CR7","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1056\/NEJMra1208937","volume":"369","author":"W Bernal","year":"2013","unstructured":"Bernal W, Wendon J (2013) Acute liver failure. N Engl J Med 369:2525\u20132534","journal-title":"N Engl J Med"},{"key":"3183_CR8","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","volume":"189","author":"B Bhushan","year":"2019","unstructured":"Bhushan B, Apte U (2019) Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities. Am J Pathol 189:719\u2013729","journal-title":"Am J Pathol"},{"key":"3183_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1586\/17512433.2014.904744","volume":"7","author":"M Blieden","year":"2014","unstructured":"Blieden M, Paramore LC, Shah D, Ben-Joseph R (2014) A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States. Expert Rev Clin Pharmacol 7:341\u2013348","journal-title":"Expert Rev Clin Pharmacol"},{"key":"3183_CR10","doi-asserted-by":"crossref","unstructured":"Bonkovsky HL, Barnhart HX, Foureau DM, Steuerwald N, Lee WM, Gu J, Fontana RJ, Hayashi PJ, Chalasani N, Navarro VM, Odin J, Stolz A, Watkins PB, Serrano J; US Drug-Induced Liver Injury Network and the Acute Liver Failure Study Group (2018) Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group. PLoS One 13:e0206389.","DOI":"10.1371\/journal.pone.0206389"},{"key":"3183_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1053\/jhep.2002.30956","volume":"35","author":"M Bourdi","year":"2002","unstructured":"Bourdi M, Masubuchi Y, Reilly TP, Amouzadeh HR, Martin JL, George JW, Shah AG, Pohl LR (2002) Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase. Hepatology 35:289\u2013298","journal-title":"Hepatology"},{"key":"3183_CR12","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1172\/JCI122258","volume":"129","author":"CJ Calvente","year":"2019","unstructured":"Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du, Jeu X, Llorente C, Boyer J, Feldstein AE (2019) Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest 129:4091\u20134109","journal-title":"J Clin Invest"},{"key":"3183_CR13","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/sj.leu.2402824","volume":"17","author":"F Chang","year":"2003","unstructured":"Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA (2003) Involvement of PI3K\/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17:590\u2013603","journal-title":"Leukemia"},{"key":"3183_CR14","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1038\/s41467-020-15584-3","volume":"11","author":"A Chauhan","year":"2020","unstructured":"Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, Bhandari R, Watson S, Adams DH, Watson SP, Lalor PF (2020) The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. Nat Commun 11:1939","journal-title":"Nat Commun"},{"key":"3183_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.1996.8074","volume":"143","author":"SD Cohen","year":"1997","unstructured":"Cohen SD, Pumford NR, Boekelheide KEA, K, Pohl LR, Amouzadeh HR, Hinson JA, (1997) Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol 143:1\u201312","journal-title":"Toxicol Appl Pharmacol"},{"key":"3183_CR16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.taap.2006.04.010","volume":"216","author":"C Cover","year":"2006","unstructured":"Cover C, Liu J, Farhood A, Malle E, Waalkes MP, Bajt ML, Jaeschke H (2006) Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 216:98\u2013107","journal-title":"Toxicol Appl Pharmacol"},{"key":"3183_CR17","doi-asserted-by":"publisher","first-page":"G880","DOI":"10.1152\/ajpgi.00317.2004","volume":"288","author":"RB Dorman","year":"2005","unstructured":"Dorman RB, Gujral JS, Bajt ML, Farhood A, Jaeschke H (2005) Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia. Am J Physiol Gastrointest Liver Physiol 288:G880\u2013G886","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3183_CR18","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.fct.2017.08.020","volume":"108","author":"K Du","year":"2017","unstructured":"Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H (2017) Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol 108:339\u2013350","journal-title":"Food Chem Toxicol"},{"key":"3183_CR19","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1172\/JCI41649","volume":"120","author":"KJ Eash","year":"2010","unstructured":"Eash KJ, Greenbaum AM, Gopalan PK, Link DC (2010) CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest 120:2423\u20132431","journal-title":"J Clin Invest"},{"key":"3183_CR20","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/toxsci\/67.2.322","volume":"67","author":"JS Gujral","year":"2002","unstructured":"Gujral JS, Knight TR, Farhood A, Bajt ML, Jaeschke H (2002) Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis? Toxicol Sci 67:322\u2013328","journal-title":"Toxicol Sci"},{"key":"3183_CR21","doi-asserted-by":"publisher","first-page":"13565","DOI":"10.1074\/jbc.M708916200","volume":"283","author":"N Hanawa","year":"2008","unstructured":"Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283:13565\u201313577","journal-title":"J Biol Chem"},{"key":"3183_CR22","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1096\/fasebj.13.12.1565","volume":"13","author":"CM Hogaboam","year":"1999","unstructured":"Hogaboam CM, Bone-Larson CL, Steinhauser ML, Lukacs NW, Colletti LM, Simpson KJ, Strieter RM, Kunkel SL (1999a) Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J 13:1565\u20131574","journal-title":"FASEB J"},{"key":"3183_CR23","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/sj.gt.3300858","volume":"6","author":"CM Hogaboam","year":"1999","unstructured":"Hogaboam CM, Simpson KJ, Chensue SW, Steinhauser ML, Lukacs NW, Gauldie J, Strieter RM, Kunkel SL (1999b) Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Gene Ther 6:573\u2013584","journal-title":"Gene Ther"},{"key":"3183_CR24","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1189\/jlb.0308173","volume":"84","author":"MP Holt","year":"2008","unstructured":"Holt MP, Cheng L, Ju C (2008) Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 84:1410\u20131421","journal-title":"J Leukoc Biol"},{"key":"3183_CR25","doi-asserted-by":"publisher","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","volume":"284","author":"H Jaeschke","year":"2003","unstructured":"Jaeschke H (2003) Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 284:G15-26","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3183_CR26","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1111\/j.1478-3231.2006.01327.x","volume":"26","author":"H Jaeschke","year":"2006","unstructured":"Jaeschke H, Hasegawa T (2006) Role of neutrophils in acute inflammatory liver injury. Liver Int 26:912\u2013919","journal-title":"Liver Int"},{"key":"3183_CR27","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1478-3231.2011.02501.x","volume":"32","author":"H Jaeschke","year":"2012","unstructured":"Jaeschke H, Williams CD, Ramachandran A, Bajt ML (2012) Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int 32:8\u201320","journal-title":"Liver Int"},{"key":"3183_CR28","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.livres.2019.10.002","volume":"3","author":"H Jaeschke","year":"2019","unstructured":"Jaeschke H, Duan L, Nguyen N, Ramachandran A (2019a) Mitochondrial Damage and Biogenesis in Acetaminophen-induced Liver Injury. Liver Res 3:150\u2013156","journal-title":"Liver Res"},{"key":"3183_CR29","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1007\/s00204-019-02597-1","volume":"93","author":"H Jaeschke","year":"2019","unstructured":"Jaeschke H, Ramachandran A, Chao X, Ding WX (2019b) Emerging and established modes of cell death during acetaminophen-induced liver injury. Arch Toxicol 93:3491\u20133502","journal-title":"Arch Toxicol"},{"key":"3183_CR30","doi-asserted-by":"crossref","unstructured":"Jaeschke H, Ramachandran A (2020) Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity. Food Chem Toxicol 138:111240.","DOI":"10.1016\/j.fct.2020.111240"},{"key":"3183_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1742-7843.2005.pto_97102.x","volume":"97","author":"LP James","year":"2005","unstructured":"James LP, Kurten RC, Lamps LW, McCullough S, Hinson JA (2005a) Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression. Basic Clin Pharmacol Toxicol 97:8\u201314","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3183_CR32","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1177\/0091270005280296","volume":"45","author":"LP James","year":"2005","unstructured":"James LP, Simpson PM, Farrar HC, Kearns GL, Wasserman GS, Blumer JL, Reed MD, Sullivan JE, Hinson JA (2005b) Cytokines and toxicity in acetaminophen overdose. J Clin Pharmacol 45:1165\u20131171","journal-title":"J Clin Pharmacol"},{"key":"3183_CR33","first-page":"195","volume":"187","author":"DJ Jollow","year":"1973","unstructured":"Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB (1973) Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 187:195\u2013202","journal-title":"J Pharmacol Exp Ther"},{"key":"3183_CR34","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1021\/tx0255976","volume":"15","author":"C Ju","year":"2002","unstructured":"Ju C, Reilly TP, Bourdi M, Radonovich MF, Brady JN, George JW, Pohl LR (2002) Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem Res Toxicol 15:1504\u20131513","journal-title":"Chem Res Toxicol"},{"key":"3183_CR35","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/hep.20437","volume":"40","author":"K Kon","year":"2004","unstructured":"Kon K, Kim JS, Jaeschke H, Lemasters JJ (2004) Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40:1170\u20131179","journal-title":"Hepatology"},{"key":"3183_CR36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-1-4939-9167-9_9","volume":"1960","author":"LK Kozicky","year":"2019","unstructured":"Kozicky LK, Sly LM (2019) Depletion and Reconstitution of Macrophages in Mice. Methods Mol Biol 1960:101\u2013112","journal-title":"Methods Mol Biol"},{"key":"3183_CR37","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1002\/hep.22471","volume":"48","author":"S Kuboki","year":"2008","unstructured":"Kuboki S, Shin T, Huber N, Eismann T, Galloway E, Schuster R, Blanchard J, Edwards MJ, Lentsch AB (2008) Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia\/reperfusion in mice. Hepatology 48:1213\u20131223","journal-title":"Hepatology"},{"key":"3183_CR38","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/toxsci\/54.2.509","volume":"54","author":"JA Lawson","year":"2000","unstructured":"Lawson JA, Farhood A, Hopper RD, Bajt ML, Jaeschke H (2000) The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 54:509\u2013516","journal-title":"Toxicol Sci"},{"key":"3183_CR39","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1002\/hep.510270226","volume":"27","author":"AB Lentsch","year":"1998","unstructured":"Lentsch AB, Yoshidome H, Cheadle WG, Miller FN, Edwards MJ (1998) Chemokine involvement in hepatic ischemia\/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 27:1172\u20131177","journal-title":"Hepatology"},{"key":"3183_CR40","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1053\/jhep.2000.9323","volume":"32","author":"AB Lentsch","year":"2000","unstructured":"Lentsch AB, Kato A, Yoshidome H, McMasters KM, Edwards MJ (2000) Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia\/reperfusion injury. Hepatology 32:169\u2013173","journal-title":"Hepatology"},{"key":"3183_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12950-015-0109-9","volume":"13","author":"J Lu","year":"2016","unstructured":"Lu J, Chatterjee M, Schmid H, Beck S, Gawaz M (2016) CXCL14 as an emerging immune and inflammatory modulator. J Inflamm (lond) 13:1","journal-title":"J Inflamm (lond)"},{"key":"3183_CR42","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1002\/hep.25801","volume":"56","author":"PE Marques","year":"2012","unstructured":"Marques PE, Amaral SS, Pires DA, Nogueira LL, Soriani FM, Lima BH, Lopes GA, Russo RC, Avila TV, Melga\u00e7o JG, Oliveira AG, Pinto MA, Lima CX, De Paula AM, Cara DC, Leite MF, Teixeira MM, Menezes GB (2012) Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. Hepatology 56:1971\u20131982","journal-title":"Hepatology"},{"key":"3183_CR43","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jhep.2004.09.015","volume":"42","author":"Y Masubuchi","year":"2005","unstructured":"Masubuchi Y, Suda C, Horie T (2005) Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice. J Hepatol 42:110\u2013116","journal-title":"J Hepatol"},{"key":"3183_CR44","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","volume":"264","author":"MR McGill","year":"2012","unstructured":"McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H (2012) Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 264:387\u2013394","journal-title":"Toxicol Appl Pharmacol"},{"key":"3183_CR45","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/01926230590881808","volume":"33","author":"HM Mehendale","year":"2005","unstructured":"Mehendale HM (2005) Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 33:41\u201351","journal-title":"Toxicol Pathol"},{"key":"3183_CR46","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41575-020-0342-4","volume":"18","author":"GK Michalopoulos","year":"2021","unstructured":"Michalopoulos GK, Bhushan B (2021) Liver regeneration: biological and pathological mechanisms and implications. Nat Rev Gastroenterol Hepatol 18:40\u201355","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3183_CR47","first-page":"185","volume":"187","author":"JR Mitchell","year":"1973","unstructured":"Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB (1973a) Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 187:185\u2013194","journal-title":"J Pharmacol Exp Ther"},{"key":"3183_CR48","first-page":"211","volume":"187","author":"JR Mitchell","year":"1973","unstructured":"Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB (1973b) Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther 187:211\u2013217","journal-title":"J Pharmacol Exp Ther"},{"key":"3183_CR49","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-1-4939-7837-3_23","volume":"1784","author":"SG Moreno","year":"2018","unstructured":"Moreno SG (2018) Depleting Macrophages In Vivo with Clodronate-Liposomes. Methods Mol Biol 1784:259\u2013262","journal-title":"Methods Mol Biol"},{"key":"3183_CR50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1055\/s-2008-1040482","volume":"10","author":"SD Nelson","year":"1990","unstructured":"Nelson SD (1990) Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 10:267\u2013278","journal-title":"Semin Liver Dis"},{"key":"3183_CR51","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00204-021-02985-6","volume":"95","author":"NT Nguyen","year":"2021","unstructured":"Nguyen NT, Akakpo JY, Weemhoff JL, Ramachandran A, Ding WX, Jaeschke H (2021a) Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice. Arch Toxicol 95:1463\u20131473","journal-title":"Arch Toxicol"},{"key":"3183_CR52","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.toxlet.2020.12.005","volume":"338","author":"NT Nguyen","year":"2021","unstructured":"Nguyen NT, Du K, Akakpo JY, Umbaugh DS, Jaeschke H, Ramachandran A (2021b) Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice. Toxicol Lett 338:21\u201331","journal-title":"Toxicol Lett"},{"key":"3183_CR53","doi-asserted-by":"publisher","first-page":"17940","DOI":"10.1074\/jbc.273.28.17940","volume":"273","author":"Y Qiu","year":"1998","unstructured":"Qiu Y, Benet LZ, Burlingame AL (1998) Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem 273:17940\u201317953","journal-title":"J Biol Chem"},{"key":"3183_CR54","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1055\/s-0039-1679919","volume":"39","author":"A Ramachandran","year":"2019","unstructured":"Ramachandran A, Jaeschke H (2019) Acetaminophen hepatotoxicity. Semin Liver Dis 39:221\u2013234","journal-title":"Semin Liver Dis"},{"key":"3183_CR55","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0002-9440(10)63684-X","volume":"163","author":"X Ren","year":"2003","unstructured":"Ren X, Carpenter A, Hogaboam C, Colletti L (2003) Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse. Am J Pathol 163:563\u2013570","journal-title":"Am J Pathol"},{"key":"3183_CR56","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.3748\/wjg.v26.i16.1879","volume":"26","author":"K Roth","year":"2020","unstructured":"Roth K, Strickland J, Copple BL (2020) Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system. World J Gastroenterol 26:1879\u20131887","journal-title":"World J Gastroenterol"},{"key":"3183_CR57","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/15563650.2012.659252","volume":"50","author":"BH Rumack","year":"2012","unstructured":"Rumack BH, Bateman DN (2012) Acetaminophen and acetylcysteine dose and duration: past, present and future. Clin Toxicol (phila) 50:91\u201398","journal-title":"Clin Toxicol (phila)"},{"key":"3183_CR58","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.taap.2010.04.015","volume":"246","author":"C Saito","year":"2010","unstructured":"Saito C, Lemasters JJ, Jaeschke H (2010) c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 246:8\u201317","journal-title":"Toxicol Appl Pharmacol"},{"key":"3183_CR59","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1126\/science.7667641","volume":"269","author":"DE Shuster","year":"1995","unstructured":"Shuster DE, Kehrli ME Jr, Ackermann MR (1995) Neutrophilia in mice that lack the murine IL-8 receptor homolog. Science 269:1590\u20131591","journal-title":"Science"},{"key":"3183_CR60","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","volume":"319","author":"MJ Smilkstein","year":"1988","unstructured":"Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med 319:1557\u20131562","journal-title":"N Engl J Med"},{"key":"3183_CR61","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1189\/jlb.0208125","volume":"86","author":"R Stillie","year":"2009","unstructured":"Stillie R, Farooq SM, Gordon JR, Stadnyk AW (2009) The functional significance behind expressing two IL-8 receptor types on PMN. J Leukoc Biol 86:529\u2013543","journal-title":"J Leukoc Biol"},{"key":"3183_CR62","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.cytogfr.2005.04.007","volume":"16","author":"RM Strieter","year":"2005","unstructured":"Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP (2005) CXC chemokines in angiogenesis. Cytokine Growth Factor Rev 16:593\u2013609","journal-title":"Cytokine Growth Factor Rev"},{"key":"3183_CR63","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1749-6632.1997.tb46265.x","volume":"832","author":"M Thelen","year":"1997","unstructured":"Thelen M, Didichenko SA (1997) G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils. Ann N Y Acad Sci 832:368\u2013382","journal-title":"Ann N Y Acad Sci"},{"key":"3183_CR64","doi-asserted-by":"publisher","first-page":"9814","DOI":"10.1016\/S0021-9258(18)81731-8","volume":"264","author":"MA Tirmenstein","year":"1989","unstructured":"Tirmenstein MA, Nelson SD (1989) Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3\u2019-hydroxyacetanilide, in mouse liver. J Biol Chem 264:9814\u20139819","journal-title":"J Biol Chem"},{"key":"3183_CR65","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-1-60327-360-2_13","volume":"605","author":"N van Rooijen","year":"2010","unstructured":"van Rooijen N, Hendrikx E (2010) Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol Biol 605:189\u2013203","journal-title":"Methods Mol Biol"},{"key":"3183_CR66","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1002\/hep.24457","volume":"54","author":"HL Van Sweringen","year":"2011","unstructured":"Van Sweringen HL, Sakai N, Tevar AD, Burns JM, Edwards MJ, Lentsch AB (2011) CXC chemokine signaling in the liver: impact on repair and regeneration. Hepatology 54:1445\u20131453","journal-title":"Hepatology"},{"key":"3183_CR67","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0022-1759(92)90223-G","volume":"146","author":"H Watanabe","year":"1992","unstructured":"Watanabe H, Ohtsuka K, Kimura M, Ikarashi Y, Ohmori K, Kusumi A, Ohteki T, Seki S, Abo T (1992) Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods 146:145\u2013154","journal-title":"J Immunol Methods"},{"key":"3183_CR68","doi-asserted-by":"publisher","first-page":"10095","DOI":"10.1074\/jbc.273.17.10095","volume":"273","author":"JR White","year":"1998","unstructured":"White JR, Lee JM, Young PR, Hertzberg RP, Jurewicz AJ, Chaikin MA, Widdowson K, Foley JJ, Martin LD, Griswold DE, Sarau HM (1998) Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273:10095\u201310098","journal-title":"J Biol Chem"},{"key":"3183_CR69","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1111\/j.1478-3231.2010.02284.x","volume":"30","author":"CD Williams","year":"2010","unstructured":"Williams CD, Bajt ML, Farhood A, Jaeschke H (2010) Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice. Liver Int 30:1280\u20131292","journal-title":"Liver Int"},{"key":"3183_CR70","doi-asserted-by":"publisher","first-page":"e0120092","DOI":"10.1371\/journal.pone.0120092","volume":"10","author":"GC Wilson","year":"2015","unstructured":"Wilson GC, Kuboki S, Freeman CM, Nojima H, Schuster RM, Edwards MJ, Lentsch AB (2015) CXC chemokines function as a rheostat for hepatocyte proliferation and liver regeneration. PLoS ONE 10:e0120092","journal-title":"PLoS ONE"},{"key":"3183_CR71","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.taap.2015.09.022","volume":"289","author":"Y Xie","year":"2015","unstructured":"Xie Y, McGill MR, Du K, Dorko K, Kumer SC, Schmitt TM, Ding WX, Jaeschke H (2015) Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. Toxicol Appl Pharmacol 289:213\u2013222","journal-title":"Toxicol Appl Pharmacol"},{"key":"3183_CR72","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","volume":"10","author":"W Yang","year":"2019","unstructured":"Yang W, Tao Y, Wu Y, Zhao X, Ye W, Zhao D, Fu L, Tian C, Yang J, He F, Tang L (2019) Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat Commun 10:1076","journal-title":"Nat Commun"},{"key":"3183_CR73","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.bcp.2013.07.006","volume":"86","author":"Q You","year":"2013","unstructured":"You Q, Holt M, Yin H, Li G, Hu CJ, Ju C (2013) Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol 86:836\u2013843","journal-title":"Biochem Pharmacol"},{"key":"3183_CR74","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10:1523","journal-title":"Nat Commun"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03183-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-021-03183-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03183-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T12:35:12Z","timestamp":1675859712000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-021-03183-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3183"],"URL":"https:\/\/doi.org\/10.1007\/s00204-021-03183-0","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]},"assertion":[{"value":"4 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}