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Me-ION shows a tendency to occur as mass poisonings around the world with a clear predilection for poor societies in developing countries. The main mechanism underlying the molecular basis of Me-ION is the inhibition of the mitochondrial oxidative phosphorylation process through the binding of the toxic metabolite of methanol\u2014formic acid\u2014with the key enzyme of this process\u2014cytochrome c oxidase. However, other mechanisms, including damage to the eye tissues by oxidative stress causing the intensification of the oxidative peroxidation process with the formation of cytotoxic compounds, as well as an increase in the synthesis of pro-inflammatory cytokines and influence on the expression of key proteins responsible for maintaining cell homeostasis, also play an important role in the pathogenesis of Me-ION. Histopathological changes in the eye tissues are mainly manifested as the degeneration of axons and glial cells of the optic nerve, often with accompanying damage of the retina that may involve all its layers. Despite the development of therapeutic approaches, persistent visual sequelae are seen in 30\u201340% of survivors. Thus, Me-ION continues to be an important problem for healthcare systems worldwide.<\/jats:p>","DOI":"10.1007\/s00204-021-03202-0","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T03:02:28Z","timestamp":1641438148000},"page":"431-451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Methanol-induced optic neuropathy: a still-present problem"],"prefix":"10.1007","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6942-2506","authenticated-orcid":false,"given":"S\u0142awomir","family":"Liberski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartlomiej J.","family":"Kaluzny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Koci\u0119cki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"3202_CR1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/jop.2010.0145","volume":"27","author":"M Abrishami","year":"2011","unstructured":"Abrishami M, Khalifeh M, Shoayb M, Abrishami M (2011) Therapeutic effects of high-dose intravenous prednisolone in methanol-induced toxic optic neuropathy. 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