{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:00:08Z","timestamp":1791932408671,"version":"4.3.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00204-021-03214-w","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T02:02:40Z","timestamp":1642212160000},"page":"859-875","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Preliminary nonclinical safety and immunogenicity of an rVSV-\u0394G-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs"],"prefix":"10.1007","volume":"96","author":[{"given":"Noa","family":"Madar-Balakirski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Rosner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Melamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz","family":"Politi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Tamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yfat","family":"Yahalom-Ronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Bar-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Ben-Shmuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assa","family":"Sittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Glinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Bar-Haim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Achdout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Erez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahar","family":"Rotem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomi","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Nyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Yitzhaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Beth-Din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Paran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Israely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3934-6493","authenticated-orcid":false,"given":"Hadar","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"issue":"9","key":"3214_CR1","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1080\/21645515.2016.1177688","volume":"12","author":"AS Agrawal","year":"2016","unstructured":"Agrawal AS, Tao X, Algaissi A et al (2016) Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. Hum Vaccin Immunother 12(9):2351\u20132356. https:\/\/doi.org\/10.1080\/21645515.2016.1177688","journal-title":"Hum Vaccin Immunother"},{"issue":"8","key":"3214_CR2","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1002\/jat.3314","volume":"36","author":"P Baldrick","year":"2016","unstructured":"Baldrick P (2016) Dose site reactions and related findings after vaccine administration in safety studies. J Appl Toxicol 36(8):980\u2013990. https:\/\/doi.org\/10.1002\/jat.3314","journal-title":"J Appl Toxicol"},{"key":"3214_CR3","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000045","author":"VM Corman","year":"2020","unstructured":"Corman VM, Landt O, Kaiser M et al (2020) Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.3.2000045","journal-title":"Euro Surveill"},{"issue":"9","key":"3214_CR4","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1586\/14760584.2016.1167603","volume":"15","author":"L Du","year":"2016","unstructured":"Du L, Tai W, Zhou Y, Jiang S (2016) Vaccines for the prevention against the threat of MERS-CoV. Expert Rev Vaccines 15(9):1123\u20131134. https:\/\/doi.org\/10.1586\/14760584.2016.1167603","journal-title":"Expert Rev Vaccines"},{"key":"3214_CR5","doi-asserted-by":"publisher","first-page":"27944","DOI":"10.1038\/srep27944","volume":"6","author":"F Farooq","year":"2016","unstructured":"Farooq F, Beck K, Paolino KM et al (2016) Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine. Sci Rep 6:27944. https:\/\/doi.org\/10.1038\/srep27944","journal-title":"Sci Rep"},{"issue":"10","key":"3214_CR6","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1080\/21645515.2019.1649532","volume":"15","author":"A Fathi","year":"2019","unstructured":"Fathi A, Dahlke C, Addo MM (2019) Recombinant vesicular stomatitis virus vector vaccines for WHO blueprint priority pathogens. Hum Vaccin Immunother 15(10):2269\u20132285. https:\/\/doi.org\/10.1080\/21645515.2019.1649532","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"3214_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1093\/ilar\/ilv009","volume":"56","author":"V Gerdts","year":"2015","unstructured":"Gerdts V, Wilson HL, Meurens F et al (2015) Large animal models for vaccine development and testing. ILAR J 56(1):53\u201362. https:\/\/doi.org\/10.1093\/ilar\/ilv009","journal-title":"ILAR J"},{"key":"3214_CR8","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001599","author":"JW Golden","year":"2021","unstructured":"Golden JW, Zeng X, Cline CR et al (2021) Human convalescent plasma protects K18-hACE2 mice against severe respiratory disease. J Gen Virol. https:\/\/doi.org\/10.1099\/jgv.0.001599","journal-title":"J Gen Virol"},{"issue":"30","key":"3214_CR9","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1016\/j.vaccine.2016.04.083","volume":"34","author":"BS Graham","year":"2016","unstructured":"Graham BS (2016) Vaccines against respiratory syncytial virus: the time has finally come. Vaccine 34(30):3535\u20133541. https:\/\/doi.org\/10.1016\/j.vaccine.2016.04.083","journal-title":"Vaccine"},{"issue":"3","key":"3214_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1600-0684.2007.00271.x","volume":"37","author":"JL Grieves","year":"2008","unstructured":"Grieves JL, Dick EJ Jr, Schlabritz-Loutsevich NE et al (2008) Barbiturate euthanasia solution-induced tissue artifact in nonhuman primates. J Med Primatol 37(3):154\u2013161. https:\/\/doi.org\/10.1111\/j.1600-0684.2007.00271.x","journal-title":"J Med Primatol"},{"issue":"3","key":"3214_CR11","first-page":"293","volume":"40","author":"JP Hannon","year":"1990","unstructured":"Hannon JP, Bossone CA, Wade CE (1990) Normal physiological values for conscious pigs used in biomedical research. Lab Anim Sci 40(3):293\u2013298","journal-title":"Lab Anim Sci"},{"key":"3214_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines7010019","author":"T Israely","year":"2019","unstructured":"Israely T, Paran N, Erez N et al (2019) Differential Response Following Infection of Mouse CNS with Virulent and Attenuated Vaccinia Virus Strains. Vaccines (basel). https:\/\/doi.org\/10.3390\/vaccines7010019","journal-title":"Vaccines (basel)"},{"key":"3214_CR13","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1743-422X-9-119","volume":"9","author":"T Israely","year":"2012","unstructured":"Israely T, Paran N, Lustig S et al (2012) A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease. Virol J 9:119. https:\/\/doi.org\/10.1186\/1743-422X-9-119","journal-title":"Virol J"},{"issue":"10","key":"3214_CR14","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1073\/pnas.92.10.4477","volume":"92","author":"ND Lawson","year":"1995","unstructured":"Lawson ND, Stillman EA, Whitt MA, Rose JK (1995) Recombinant vesicular stomatitis viruses from DNA. Proc Natl Acad Sci U S A 92(10):4477\u20134481. https:\/\/doi.org\/10.1073\/pnas.92.10.4477","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"3214_CR15","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/s41564-020-00789-5","volume":"5","author":"WS Lee","year":"2020","unstructured":"Lee WS, Wheatley AK, Kent SJ, DeKosky BJ (2020) Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies. Nat Microbiol 5(10):1185\u20131191. https:\/\/doi.org\/10.1038\/s41564-020-00789-5","journal-title":"Nat Microbiol"},{"key":"3214_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/v11010035","author":"A Marin-Lopez","year":"2019","unstructured":"Marin-Lopez A, Calvo-Pinilla E, Moreno S et al (2019) Modeling arboviral infection in mice lacking the interferon alpha\/beta receptor. Viruses. https:\/\/doi.org\/10.3390\/v11010035","journal-title":"Viruses"},{"issue":"2","key":"3214_CR17","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1128\/JVI.02012-06","volume":"81","author":"PB McCray Jr","year":"2007","unstructured":"McCray PB Jr, Pewe L, Wohlford-Lenane C et al (2007) Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol 81(2):813\u2013821. https:\/\/doi.org\/10.1128\/JVI.02012-06","journal-title":"J Virol"},{"issue":"3","key":"3214_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001567","volume":"6","author":"CE Mire","year":"2012","unstructured":"Mire CE, Miller AD, Carville A et al (2012) Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates. PLoS Negl Trop Dis 6(3):e1567. https:\/\/doi.org\/10.1371\/journal.pntd.0001567","journal-title":"PLoS Negl Trop Dis"},{"key":"3214_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvacx.2019.100009","volume":"1","author":"TP Monath","year":"2019","unstructured":"Monath TP, Fast PE, Modjarrad K et al (2019) rVSVDeltaG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk\/benefit assessment. Vaccine X 1:100009. https:\/\/doi.org\/10.1016\/j.jvacx.2019.100009","journal-title":"Vaccine X"},{"issue":"11","key":"3214_CR20","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1128\/JVI.02511-10","volume":"85","author":"A Muik","year":"2011","unstructured":"Muik A, Kneiske I, Werbizki M et al (2011) Pseudotyping vesicular stomatitis virus with lymphocytic choriomeningitis virus glycoproteins enhances infectivity for glioma cells and minimizes neurotropism. J Virol 85(11):5679\u20135684. https:\/\/doi.org\/10.1128\/JVI.02511-10","journal-title":"J Virol"},{"issue":"13","key":"3214_CR21","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1158\/0008-5472.CAN-13-3306","volume":"74","author":"A Muik","year":"2014","unstructured":"Muik A, Stubbert LJ, Jahedi RZ et al (2014) Re-engineering vesicular stomatitis virus to abrogate neurotoxicity, circumvent humoral immunity, and enhance oncolytic potency. Cancer Res 74(13):3567\u20133578. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-3306","journal-title":"Cancer Res"},{"issue":"7830","key":"3214_CR22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41586-020-2787-6","volume":"586","author":"C Munoz-Fontela","year":"2020","unstructured":"Munoz-Fontela C, Dowling WE, Funnell SGP et al (2020) Animal models for COVID-19. Nature 586(7830):509\u2013515. https:\/\/doi.org\/10.1038\/s41586-020-2787-6","journal-title":"Nature"},{"issue":"1","key":"3214_CR23","doi-asserted-by":"publisher","first-page":"4303","DOI":"10.1038\/s41467-020-18159-4","volume":"11","author":"T Noy-Porat","year":"2020","unstructured":"Noy-Porat T, Makdasi E, Alcalay R et al (2020) A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes. Nat Commun 11(1):4303. https:\/\/doi.org\/10.1038\/s41467-020-18159-4","journal-title":"Nat Commun"},{"issue":"1","key":"3214_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1203\/PDR.0b013e3180686ce0","volume":"62","author":"FP Polack","year":"2007","unstructured":"Polack FP (2007) Atypical measles and enhanced respiratory syncytial virus disease (ERD) made simple. Pediatr Res 62(1):111\u2013115. https:\/\/doi.org\/10.1203\/PDR.0b013e3180686ce0","journal-title":"Pediatr Res"},{"key":"3214_CR25","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc3539","author":"S Ravichandran","year":"2020","unstructured":"Ravichandran S, Coyle EM, Klenow L et al (2020) Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits. Sci Transl Med. https:\/\/doi.org\/10.1126\/scitranslmed.abc3539","journal-title":"Sci Transl Med"},{"key":"3214_CR26","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2020-10-3","author":"M Rodriguez-Guerra","year":"2021","unstructured":"Rodriguez-Guerra M, Jadhav P, Vittorio TJ (2021) Current treatment in COVID-19 disease: a rapid review. Drugs Context. https:\/\/doi.org\/10.7573\/dic.2020-10-3","journal-title":"Drugs Context"},{"issue":"3","key":"3214_CR27","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/0192623318761348","volume":"46","author":"KA Schafer","year":"2018","unstructured":"Schafer KA, Eighmy J, Fikes JD et al (2018) Use of severity grades to characterize histopathologic changes. Toxicol Pathol 46(3):256\u2013265. https:\/\/doi.org\/10.1177\/0192623318761348","journal-title":"Toxicol Pathol"},{"issue":"9","key":"3214_CR28","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1080\/21645515.2018.1473698","volume":"14","author":"E Suder","year":"2018","unstructured":"Suder E, Furuyama W, Feldmann H, Marzi A, de Wit E (2018) The vesicular stomatitis virus-based Ebola virus vaccine: from concept to clinical trials. Hum Vaccin Immunother 14(9):2107\u20132113. https:\/\/doi.org\/10.1080\/21645515.2018.1473698","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"3214_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05850","volume":"7","author":"K Sun","year":"2021","unstructured":"Sun K, Gu L, Ma L et al (2021) Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2. Heliyon 7(1):e05850. https:\/\/doi.org\/10.1016\/j.heliyon.2020.e05850","journal-title":"Heliyon"},{"issue":"2","key":"3214_CR30","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.bbrc.2014.07.090","volume":"451","author":"SF Wang","year":"2014","unstructured":"Wang SF, Tseng SP, Yen CH et al (2014) Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins. Biochem Biophys Res Commun 451(2):208\u2013214. https:\/\/doi.org\/10.1016\/j.bbrc.2014.07.090","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"3214_CR31","doi-asserted-by":"publisher","first-page":"12672","DOI":"10.1128\/JVI.78.22.12672-12676.2004","volume":"78","author":"H Weingartl","year":"2004","unstructured":"Weingartl H, Czub M, Czub S et al (2004) Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets. J Virol 78(22):12672\u201312676. https:\/\/doi.org\/10.1128\/JVI.78.22.12672-12676.2004","journal-title":"J Virol"},{"key":"3214_CR32","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0384-2020","author":"T Welte","year":"2021","unstructured":"Welte T, Ambrose LJ, Sibbring GC, Sheikh S, Mullerova H, Sabir I (2021) Current evidence for COVID-19 therapies: a systematic literature review. Eur Respir Rev. https:\/\/doi.org\/10.1183\/16000617.0384-2020","journal-title":"Eur Respir Rev"},{"issue":"6","key":"3214_CR33","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1177\/0192623319867053","volume":"47","author":"CL Willard-Mack","year":"2019","unstructured":"Willard-Mack CL, Elmore SA, Hall WC et al (2019) Nonproliferative and proliferative lesions of the rat and mouse hematolymphoid system. Toxicol Pathol 47(6):665\u2013783. https:\/\/doi.org\/10.1177\/0192623319867053","journal-title":"Toxicol Pathol"},{"issue":"1","key":"3214_CR34","doi-asserted-by":"publisher","first-page":"6402","DOI":"10.1038\/s41467-020-20228-7","volume":"11","author":"Y Yahalom-Ronen","year":"2020","unstructured":"Yahalom-Ronen Y, Tamir H, Melamed S et al (2020) A single dose of recombinant VSV-G-spike vaccine provides protection against SARS-CoV-2 challenge. Nat Commun 11(1):6402. https:\/\/doi.org\/10.1038\/s41467-020-20228-7","journal-title":"Nat Commun"},{"issue":"1","key":"3214_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009195","volume":"17","author":"CK Yinda","year":"2021","unstructured":"Yinda CK, Port JR, Bushmaker T et al (2021) K18-hACE2 mice develop respiratory disease resembling severe COVID-19. PLoS Pathog 17(1):e1009195. https:\/\/doi.org\/10.1371\/journal.ppat.1009195","journal-title":"PLoS Pathog"},{"issue":"7843","key":"3214_CR36","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41586-020-2943-z","volume":"589","author":"J Zheng","year":"2021","unstructured":"Zheng J, Wong LR, Li K et al (2021) COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature 589(7843):603\u2013607. https:\/\/doi.org\/10.1038\/s41586-020-2943-z","journal-title":"Nature"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03214-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-021-03214-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-021-03214-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T14:03:15Z","timestamp":1645020195000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-021-03214-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,15]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["3214"],"URL":"https:\/\/doi.org\/10.1007\/s00204-021-03214-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.06.451119","asserted-by":"object"}]},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,15]]},"assertion":[{"value":"4 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Experiments were approved by the IIBR animal care and use committee (IACUC) and performed in accordance with the guidelines of the care and use of laboratory animals published by the Israeli Ministry of Health (protocols: mice C57BL\/6J # No. M-52-20, Ifnar1 knock-out and hACE2-K18 mice # No. M-65-20, hamster # No. HM-02-20, rabbits # No. RB-13-29, pigs # No. P-03-20).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Patent application for the described vaccine was filed by the Israel Institute for Biological Research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patents"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}