{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:50:46Z","timestamp":1791528646934,"version":"4.3.4"},"reference-count":397,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01DN16039"],"award-info":[{"award-number":["01DN16039"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH345"],"award-info":[{"award-number":["TH345"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ZBAF Universitat Witten\/Herdecke"},{"name":"IFF Universitat Witten\/Herdecke","award":["IFF 2018-52"],"award-info":[{"award-number":["IFF 2018-52"]}]},{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The kidney is the main organ that senses changes in systemic oxygen tension, but it\u00a0is also the key detoxification, transit and excretion site of transition metals (TMs). Pivotal to oxygen sensing are prolyl-hydroxylases (PHDs), which hydroxylate specific residues in hypoxia-inducible factors (HIFs), key transcription factors that orchestrate responses to hypoxia, such as induction of erythropoietin (EPO). The essential TM ion Fe is a key component and regulator of the hypoxia\u2013PHD\u2013HIF\u2013EPO (HPHE) signaling axis, which governs erythropoiesis, angiogenesis, anaerobic metabolism, adaptation, survival and proliferation, and hence cell and body homeostasis. However, inadequate concentrations of essential TMs or entry of non-essential TMs in organisms cause toxicity and disrupt health. Non-essential TMs are toxic because they enter cells and displace essential TMs by ionic and molecular mimicry, e. g. in metalloproteins. Here, we review the molecular mechanisms of HPHE interactions with TMs (Fe, Co, Ni, Cd, Cr, and Pt) as well as their implications in renal physiology, pathophysiology and toxicology. Some TMs, such as Fe and Co, may activate renal HPHE signaling, which may be beneficial under some circumstances, for example, by\u00a0mitigating renal injuries from other causes, but may also promote pathologies, such as renal cancer development and metastasis. Yet some other TMs appear to disrupt renal HPHE signaling, contributing to the complex picture of TM (nephro-)toxicity. Strikingly, despite a wealth of literature on the topic, current knowledge lacks a deeper molecular understanding of TM interaction with HPHE signaling, in particular in the kidney. This precludes rationale preventive and therapeutic approaches to TM nephrotoxicity, although recently activators of HPHE signaling have become available for therapy.<\/jats:p>","DOI":"10.1007\/s00204-022-03285-3","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T11:04:12Z","timestamp":1650539052000},"page":"1573-1607","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Renal hypoxia\u2013HIF\u2013PHD\u2013EPO signaling in transition metal nephrotoxicity: friend or foe?"],"prefix":"10.1007","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-3498","authenticated-orcid":false,"given":"Frank","family":"Th\u00e9venod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Kee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"issue":"6","key":"3285_CR1","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1177\/1535370215581314","volume":"240","author":"L Adams","year":"2015","unstructured":"Adams L, Franco MC, Estevez AG (2015) Reactive nitrogen species in cellular signaling. Exp Biol Med (maywood) 240(6):711\u2013717. https:\/\/doi.org\/10.1177\/1535370215581314","journal-title":"Exp Biol Med (maywood)"},{"issue":"5","key":"3285_CR2","doi-asserted-by":"publisher","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","volume":"314","author":"O Adedoyin","year":"2018","unstructured":"Adedoyin O, Boddu R, Traylor A et al (2018) Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells. Am J Physiol Renal Physiol 314(5):F702\u2013F714. https:\/\/doi.org\/10.1152\/ajprenal.00044.2017","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"3285_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1681\/ASN.V115965","volume":"11","author":"A Agarwal","year":"2000","unstructured":"Agarwal A, Nick HS (2000) Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol 11(5):965\u2013973. https:\/\/doi.org\/10.1681\/ASN.V115965","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"3285_CR4","doi-asserted-by":"publisher","first-page":"e48952","DOI":"10.1371\/journal.pone.0048952","volume":"7","author":"JM Ahn","year":"2012","unstructured":"Ahn JM, You SJ, Lee YM et al (2012) Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury. PLoS ONE 7(11):e48952. https:\/\/doi.org\/10.1371\/journal.pone.0048952","journal-title":"PLoS ONE"},{"issue":"2","key":"3285_CR5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000454818","volume":"45","author":"T Akizawa","year":"2017","unstructured":"Akizawa T, Tsubakihara Y, Nangaku M et al (2017) Effects of daprodustat, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor on anemia management in Japanese hemodialysis subjects. Am J Nephrol 45(2):127\u2013135. https:\/\/doi.org\/10.1159\/000454818","journal-title":"Am J Nephrol"},{"issue":"4","key":"3285_CR6","doi-asserted-by":"publisher","first-page":"F743","DOI":"10.1152\/ajprenal.00376.2002","volume":"284","author":"J Alam","year":"2003","unstructured":"Alam J, Killeen E, Gong P et al (2003) Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2. Am J Physiol Renal Physiol 284(4):F743\u2013F752. https:\/\/doi.org\/10.1152\/ajprenal.00376.2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"3285_CR7","doi-asserted-by":"publisher","first-page":"476430","DOI":"10.1155\/2014\/476430","volume":"2014","author":"MA Al-Kahtani","year":"2014","unstructured":"Al-Kahtani MA, Abdel-Moneim AM, Elmenshawy OM, El-Kersh MA (2014) Hemin attenuates cisplatin-induced acute renal injury in male rats. Oxid Med Cell Longev 2014:476430. https:\/\/doi.org\/10.1155\/2014\/476430","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"3285_CR8","doi-asserted-by":"publisher","first-page":"L607","DOI":"10.1152\/ajplung.2001.281.3.L607","volume":"281","author":"AS Andrew","year":"2001","unstructured":"Andrew AS, Klei LR, Barchowsky A (2001) Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Am J Physiol Lung Cell Mol Physiol 281(3):L607\u2013L615. https:\/\/doi.org\/10.1152\/ajplung.2001.281.3.L607","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"37","key":"3285_CR9","doi-asserted-by":"publisher","first-page":"38458","DOI":"10.1074\/jbc.M406026200","volume":"279","author":"RJ Appelhoff","year":"2004","unstructured":"Appelhoff RJ, Tian YM, Raval RR et al (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279(37):38458\u201338465. https:\/\/doi.org\/10.1074\/jbc.M406026200","journal-title":"J Biol Chem"},{"issue":"1","key":"3285_CR10","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12931-019-1100-4","volume":"20","author":"A Aquino-Galvez","year":"2019","unstructured":"Aquino-Galvez A, Gonzalez-Avila G, Jimenez-Sanchez LL et al (2019) Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis. Respir Res 20(1):130. https:\/\/doi.org\/10.1186\/s12931-019-1100-4","journal-title":"Respir Res"},{"issue":"3","key":"3285_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1124\/jpet.117.242503","volume":"363","author":"JL Ariazi","year":"2017","unstructured":"Ariazi JL, Duffy KJ, Adams DF et al (2017) Discovery and preclinical characterization of GSK1278863 (daprodustat), a small molecule hypoxia inducible factor-prolyl hydroxylase inhibitor for anemia. J Pharmacol Exp Ther 363(3):336\u2013347. https:\/\/doi.org\/10.1124\/jpet.117.242503","journal-title":"J Pharmacol Exp Ther"},{"issue":"2\u20133","key":"3285_CR12","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.tox.2005.11.010","volume":"218","author":"L Arreola-Mendoza","year":"2006","unstructured":"Arreola-Mendoza L, Reyes JL, Melendez E et al (2006) Alpha-tocopherol protects against the renal damage caused by potassium dichromate. Toxicology 218(2\u20133):237\u2013246. https:\/\/doi.org\/10.1016\/j.tox.2005.11.010","journal-title":"Toxicology"},{"issue":"10","key":"3285_CR13","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1172\/JCI57301","volume":"121","author":"N Asada","year":"2011","unstructured":"Asada N, Takase M, Nakamura J et al (2011) Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice. J Clin Invest 121(10):3981\u20133990. https:\/\/doi.org\/10.1172\/JCI57301","journal-title":"J Clin Invest"},{"key":"3285_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09603123.2021.1929871","volume":"2","author":"J Ashley-Martin","year":"2021","unstructured":"Ashley-Martin J, Iannotti L, Lesorogol C et al (2021) Heavy metal blood concentrations in association with sociocultural characteristics, anthropometry and anemia among Kenyan adolescents. Int J Environ Health Res 2:1\u201315. https:\/\/doi.org\/10.1080\/09603123.2021.1929871","journal-title":"Int J Environ Health Res"},{"key":"3285_CR15","unstructured":"ATSDR (2004) toxicological profile for cobalt. In: Agency for Toxic Substance and Disease Registry US (ed). Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A."},{"key":"3285_CR16","unstructured":"ATSDR (2005) toxicological profile for nickel (update). In: Agency for Toxic Substance and Disease Registry US (ed). Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A."},{"key":"3285_CR17","unstructured":"ATSDR (2012) Toxicological profile for chromium. In: Agency for Toxic Substance and Disease Registry US (ed). Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles. Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A."},{"key":"3285_CR18","unstructured":"ATSDR (2019) The ATSDR 2019 substance priority list (SPL). In: Agency for Toxic Substance and Disease Registry US (ed). Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A., p https:\/\/www.atsdr.cdc.gov\/spl\/index.html"},{"key":"3285_CR19","unstructured":"ATSDR (2021) Toxicological profiles. In: Agency for Toxic Substance and Disease Registry US (ed). Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A., p https:\/\/www.atsdr.cdc.gov\/toxprofiledocs\/index.html"},{"issue":"3","key":"3285_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/41.3.8429197","volume":"41","author":"S Bachmann","year":"1993","unstructured":"Bachmann S, Le Hir M, Eckardt KU (1993) Co-localization of erythropoietin mRNA and ecto-5\u2019-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin. J Histochem Cytochem 41(3):335\u2013341. https:\/\/doi.org\/10.1177\/41.3.8429197","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"3285_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1476-5829.2007.00142.x","volume":"6","author":"K Barabas","year":"2008","unstructured":"Barabas K, Milner R, Lurie D, Adin C (2008) Cisplatin: a review of toxicities and therapeutic applications. Vet Comp Oncol 6(1):1\u201318. https:\/\/doi.org\/10.1111\/j.1476-5829.2007.00142.x","journal-title":"Vet Comp Oncol"},{"issue":"3","key":"3285_CR22","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1681\/ASN.2004060494","volume":"16","author":"AG Basnakian","year":"2005","unstructured":"Basnakian AG, Apostolov EO, Yin X, Napirei M, Mannherz HG, Shah SV (2005) Cisplatin nephrotoxicity is mediated by deoxyribonuclease I. J Am Soc Nephrol 16(3):697\u2013702. https:\/\/doi.org\/10.1681\/ASN.2004060494","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"3285_CR23","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/S0021-9258(19)75664-6","volume":"262","author":"CJ Batie","year":"1987","unstructured":"Batie CJ, LaHaie E, Ballou DP (1987) Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia. J Biol Chem 262(4):1510\u20131518","journal-title":"J Biol Chem"},{"issue":"4","key":"3285_CR24","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.transci.2017.07.021","volume":"56","author":"T Bayhan","year":"2017","unstructured":"Bayhan T, Unal S, Cirak E et al (2017) Heavy metal levels in patients with ineffective erythropoiesis. Transfus Apher Sci 56(4):539\u2013543. https:\/\/doi.org\/10.1016\/j.transci.2017.07.021","journal-title":"Transfus Apher Sci"},{"key":"3285_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122598","author":"DC Belisario","year":"2020","unstructured":"Belisario DC, Kopecka J, Pasino M et al (2020) hypoxia dictates metabolic rewiring of tumors: implications for chemoresistance. Cells. https:\/\/doi.org\/10.3390\/cells9122598","journal-title":"Cells"},{"issue":"5","key":"3285_CR26","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.mito.2005.06.005","volume":"5","author":"EL Bell","year":"2005","unstructured":"Bell EL, Emerling BM, Chandel NS (2005) Mitochondrial regulation of oxygen sensing. Mitochondrion 5(5):322\u2013332. https:\/\/doi.org\/10.1016\/j.mito.2005.06.005","journal-title":"Mitochondrion"},{"issue":"6","key":"3285_CR27","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1083\/jcb.200609074","volume":"177","author":"EL Bell","year":"2007","unstructured":"Bell EL, Klimova TA, Eisenbart J et al (2007) The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177(6):1029\u20131036. https:\/\/doi.org\/10.1083\/jcb.200609074","journal-title":"J Cell Biol"},{"issue":"7","key":"3285_CR28","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1681\/ASN.2005121302","volume":"17","author":"WM Bernhardt","year":"2006","unstructured":"Bernhardt WM, Campean V, Kany S et al (2006a) Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol 17(7):1970\u20131978. https:\/\/doi.org\/10.1681\/ASN.2005121302","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3285_CR29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/sj.ki.5000062","volume":"69","author":"WM Bernhardt","year":"2006","unstructured":"Bernhardt WM, Schmitt R, Rosenberger C et al (2006b) Expression of hypoxia-inducible transcription factors in developing human and rat kidneys. Kidney Int 69(1):114\u2013122. https:\/\/doi.org\/10.1038\/sj.ki.5000062","journal-title":"Kidney Int"},{"key":"3285_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0076-6879(07)35012-X","volume":"435","author":"WM Bernhardt","year":"2007","unstructured":"Bernhardt WM, Warnecke C, Willam C, Tanaka T, Wiesener MS, Eckardt KU (2007) Organ protection by hypoxia and hypoxia-inducible factors. Methods Enzymol 435:221\u2013245. https:\/\/doi.org\/10.1016\/S0076-6879(07)35012-X","journal-title":"Methods Enzymol"},{"issue":"16","key":"3285_CR31","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1093\/emboj\/cdg392","volume":"22","author":"E Berra","year":"2003","unstructured":"Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22(16):4082\u20134090. https:\/\/doi.org\/10.1093\/emboj\/cdg392","journal-title":"EMBO J"},{"issue":"10","key":"3285_CR32","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1093\/ndt\/gfv302","volume":"30","author":"A Besarab","year":"2015","unstructured":"Besarab A, Provenzano R, Hertel J et al (2015) Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients. Nephrol Dial Transplant 30(10):1665\u20131673. https:\/\/doi.org\/10.1093\/ndt\/gfv302","journal-title":"Nephrol Dial Transplant"},{"issue":"52","key":"3285_CR33","doi-asserted-by":"publisher","first-page":"36542","DOI":"10.1074\/jbc.M804578200","volume":"283","author":"S Beyer","year":"2008","unstructured":"Beyer S, Kristensen MM, Jensen KS, Johansen JV, Staller P (2008) The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem 283(52):36542\u201336552. https:\/\/doi.org\/10.1074\/jbc.M804578200","journal-title":"J Biol Chem"},{"issue":"5","key":"3285_CR34","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s10534-011-9451-4","volume":"24","author":"MR Bleackley","year":"2011","unstructured":"Bleackley MR, Macgillivray RT (2011) Transition metal homeostasis: from yeast to human disease. Biometals 24(5):785\u2013809. https:\/\/doi.org\/10.1007\/s10534-011-9451-4","journal-title":"Biometals"},{"issue":"5","key":"3285_CR35","doi-asserted-by":"publisher","first-page":"F385","DOI":"10.1152\/ajprenal.00335.2015","volume":"310","author":"S Bolisetty","year":"2016","unstructured":"Bolisetty S, Traylor A, Joseph R, Zarjou A, Agarwal A (2016) Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol 310(5):F385\u2013F394. https:\/\/doi.org\/10.1152\/ajprenal.00335.2015","journal-title":"Am J Physiol Renal Physiol"},{"issue":"32","key":"3285_CR36","doi-asserted-by":"publisher","first-page":"22575","DOI":"10.1074\/jbc.M600288200","volume":"281","author":"CP Bracken","year":"2006","unstructured":"Bracken CP, Fedele AO, Linke S et al (2006) Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem 281(32):22575\u201322585. https:\/\/doi.org\/10.1074\/jbc.M600288200","journal-title":"J Biol Chem"},{"issue":"1","key":"3285_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellsig.2004.04.010","volume":"17","author":"C Brahimi-Horn","year":"2005","unstructured":"Brahimi-Horn C, Mazure N, Pouyssegur J (2005) Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications. Cell Signal 17(1):1\u20139. https:\/\/doi.org\/10.1016\/j.cellsig.2004.04.010","journal-title":"Cell Signal"},{"issue":"1","key":"3285_CR38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.toxlet.2003.12.074","volume":"151","author":"H Brauch","year":"2004","unstructured":"Brauch H, Weirich G, Klein B, Rabstein S, Bolt HM, Bruning T (2004) VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference? Toxicol Lett 151(1):301\u2013310. https:\/\/doi.org\/10.1016\/j.toxlet.2003.12.074","journal-title":"Toxicol Lett"},{"issue":"3","key":"3285_CR39","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.taap.2004.09.007","volume":"204","author":"CC Bridges","year":"2005","unstructured":"Bridges CC, Zalups RK (2005) Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 204(3):274\u2013308","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"3285_CR40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/10937404.2016.1243501","volume":"20","author":"CC Bridges","year":"2017","unstructured":"Bridges CC, Zalups RK (2017) The aging kidney and the nephrotoxic effects of mercury. J Toxicol Environ Health B Crit Rev 20(2):55\u201380. https:\/\/doi.org\/10.1080\/10937404.2016.1243501","journal-title":"J Toxicol Environ Health B Crit Rev"},{"issue":"6","key":"3285_CR41","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1053\/j.ajkd.2015.11.021","volume":"67","author":"RA Brigandi","year":"2016","unstructured":"Brigandi RA, Johnson B, Oei C et al (2016) A novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (GSK1278863) for anemia in CKD: a 28-day, phase 2A randomized trial. Am J Kidney Dis 67(6):861\u2013871. https:\/\/doi.org\/10.1053\/j.ajkd.2015.11.021","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"3285_CR42","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cell.2016.05.042","volume":"166","author":"KJ Briggs","year":"2016","unstructured":"Briggs KJ, Koivunen P, Cao S et al (2016) Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine. Cell 166(1):126\u2013139. https:\/\/doi.org\/10.1016\/j.cell.2016.05.042","journal-title":"Cell"},{"issue":"1","key":"3285_CR43","doi-asserted-by":"publisher","first-page":"F243","DOI":"10.1152\/ajprenal.00236.2006","volume":"292","author":"C Brooks","year":"2007","unstructured":"Brooks C, Wang J, Yang T, Dong Z (2007) Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Am J Physiol Renal Physiol 292(1):F243\u2013F252. https:\/\/doi.org\/10.1152\/ajprenal.00236.2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"3285_CR44","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cmet.2005.05.002","volume":"1","author":"JK Brunelle","year":"2005","unstructured":"Brunelle JK, Bell EL, Quesada NM et al (2005) Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 1(6):409\u2013414. https:\/\/doi.org\/10.1016\/j.cmet.2005.05.002","journal-title":"Cell Metab"},{"issue":"1","key":"3285_CR45","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/(SICI)1098-2264(199709)20:1<9::AID-GCC2>3.0.CO;2-Z","volume":"20","author":"P Bugert","year":"1997","unstructured":"Bugert P, Wilhelm M, Kovacs G (1997) FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas. Genes Chromosomes Cancer 20(1):9\u201315","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"3285_CR46","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/s41585-021-00487-9","volume":"18","author":"N Burrows","year":"2021","unstructured":"Burrows N, Maxwell PH (2021) Hypoxia-inducible factor 2 inhibitors show promise in advanced kidney cancer. Nat Rev Urol 18(9):516\u2013517. https:\/\/doi.org\/10.1038\/s41585-021-00487-9","journal-title":"Nat Rev Urol"},{"issue":"10","key":"3285_CR47","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.2764","volume":"45","author":"JN Weinstein","year":"2013","unstructured":"Cancer Genome Atlas Research N, Weinstein JN, Collisson EA et al (2013) The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113\u20131120. https:\/\/doi.org\/10.1038\/ng.2764","journal-title":"Nat Genet"},{"issue":"6","key":"3285_CR48","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1111\/j.1582-4934.2011.01258.x","volume":"15","author":"A Carreau","year":"2011","unstructured":"Carreau A, El Hafny-Rahbi B, Matejuk A, Grillon C, Kieda C (2011) Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia. J Cell Mol Med 15(6):1239\u20131253. https:\/\/doi.org\/10.1111\/j.1582-4934.2011.01258.x","journal-title":"J Cell Mol Med"},{"issue":"8","key":"3285_CR49","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/nm1075","volume":"10","author":"DJ Ceradini","year":"2004","unstructured":"Ceradini DJ, Kulkarni AR, Callaghan MJ et al (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10(8):858\u2013864. https:\/\/doi.org\/10.1038\/nm1075","journal-title":"Nat Med"},{"issue":"20","key":"3285_CR50","doi-asserted-by":"publisher","first-page":"11715","DOI":"10.1073\/pnas.95.20.11715","volume":"95","author":"NS Chandel","year":"1998","unstructured":"Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95(20):11715\u201311720. https:\/\/doi.org\/10.1073\/pnas.95.20.11715","journal-title":"Proc Natl Acad Sci USA"},{"issue":"33","key":"3285_CR51","doi-asserted-by":"publisher","first-page":"25130","DOI":"10.1074\/jbc.M001914200","volume":"275","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, McClintock DS, Feliciano CE et al (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem 275(33):25130\u201325138. https:\/\/doi.org\/10.1074\/jbc.M001914200","journal-title":"J Biol Chem"},{"key":"3285_CR52","volume-title":"Compendium of chemical terminology","author":"Chemistry IUoPaA","year":"1997","unstructured":"Chemistry IUoPaA (1997) Compendium of chemical terminology, 2nd edn. Blackwell Scientific Publications, Oxford","edition":"2"},{"issue":"12","key":"3285_CR53","doi-asserted-by":"publisher","first-page":"9519","DOI":"10.1074\/jbc.M010144200","volume":"276","author":"C Chen","year":"2001","unstructured":"Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1 interaction between H-ras and hypoxia. J Biol Chem 276(12):9519\u20139525. https:\/\/doi.org\/10.1074\/jbc.M010144200","journal-title":"J Biol Chem"},{"issue":"3","key":"3285_CR54","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.taap.2004.11.011","volume":"206","author":"H Chen","year":"2005","unstructured":"Chen H, Davidson T, Singleton S, Garrick MD, Costa M (2005) Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275\u2013287. https:\/\/doi.org\/10.1016\/j.taap.2004.11.011","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8","key":"3285_CR55","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/15287390903421250","volume":"73","author":"CY Chen","year":"2010","unstructured":"Chen CY, Lin TK, Chang YC et al (2010) Nickel(II)-induced oxidative stress, apoptosis, G2\/M arrest, and genotoxicity in normal rat kidney cells. J Toxicol Environ Health A 73(8):529\u2013539. https:\/\/doi.org\/10.1080\/15287390903421250","journal-title":"J Toxicol Environ Health A"},{"issue":"8","key":"3285_CR56","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1093\/ndt\/gfx011","volume":"32","author":"N Chen","year":"2017","unstructured":"Chen N, Qian J, Chen J et al (2017) Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China. Nephrol Dial Transplant 32(8):1373\u20131386. https:\/\/doi.org\/10.1093\/ndt\/gfx011","journal-title":"Nephrol Dial Transplant"},{"key":"3285_CR57","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1146\/annurev-pharmtox-010818-021031","volume":"59","author":"QY Chen","year":"2019","unstructured":"Chen QY, DesMarais T, Costa M (2019a) Metals and mechanisms of carcinogenesis. Annu Rev Pharmacol Toxicol 59:537\u2013554. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010818-021031","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3285_CR58","doi-asserted-by":"publisher","first-page":"114636","DOI":"10.1016\/j.taap.2019.114636","volume":"377","author":"QY Chen","year":"2019","unstructured":"Chen QY, Murphy A, Sun H, Costa M (2019b) Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis. Toxicol Appl Pharmacol 377:114636. https:\/\/doi.org\/10.1016\/j.taap.2019.114636","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7","key":"3285_CR59","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1039\/c2mt20033c","volume":"4","author":"Y Chervona","year":"2012","unstructured":"Chervona Y, Arita A, Costa M (2012) Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics Integr Biomet Sci 4(7):619\u2013627. https:\/\/doi.org\/10.1039\/c2mt20033c","journal-title":"Metallomics Integr Biomet Sci"},{"issue":"4","key":"3285_CR60","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/ijerph14040388","volume":"14","author":"J Choi","year":"2017","unstructured":"Choi J, Chang JY, Hong J, Shin S, Park JS, Oh S (2017) Low-level toxic metal exposure in healthy weaning-age infants: association with growth, dietary intake, and iron deficiency. Int J Environ Res Public Health 14(4):388. https:\/\/doi.org\/10.3390\/ijerph14040388","journal-title":"Int J Environ Res Public Health"},{"issue":"5","key":"3285_CR61","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/s41591-021-01324-7","volume":"27","author":"TK Choueiri","year":"2021","unstructured":"Choueiri TK, Bauer TM, Papadopoulos KP et al (2021) Inhibition of hypoxia-inducible factor-2alpha in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis. Nat Med 27(5):802\u2013805. https:\/\/doi.org\/10.1038\/s41591-021-01324-7","journal-title":"Nat Med"},{"key":"3285_CR62","doi-asserted-by":"publisher","first-page":"12673","DOI":"10.1038\/ncomms12673","volume":"7","author":"R Chowdhury","year":"2016","unstructured":"Chowdhury R, Leung IK, Tian YM et al (2016) Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nat Commun 7:12673. https:\/\/doi.org\/10.1038\/ncomms12673","journal-title":"Nat Commun"},{"key":"3285_CR63","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nrm778","volume":"3","author":"EI Christensen","year":"2002","unstructured":"Christensen EI, Birn H (2002) Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 3:256\u2013266","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"13","key":"3285_CR64","doi-asserted-by":"publisher","first-page":"4198","DOI":"10.1046\/j.1432-1327.2000.01453.x","volume":"267","author":"YS Chun","year":"2000","unstructured":"Chun YS, Choi E, Kim GT et al (2000) Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1alpha. Eur J Biochem 267(13):4198\u20134204. https:\/\/doi.org\/10.1046\/j.1432-1327.2000.01453.x","journal-title":"Eur J Biochem"},{"issue":"1","key":"3285_CR65","first-page":"547","volume":"34","author":"G Ciarimboli","year":"2014","unstructured":"Ciarimboli G (2014) Membrane transporters as mediators of cisplatin side-effects. Anticancer Res 34(1):547\u2013550","journal-title":"Anticancer Res"},{"issue":"6","key":"3285_CR66","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/S0002-9440(10)61234-5","volume":"167","author":"G Ciarimboli","year":"2005","unstructured":"Ciarimboli G, Ludwig T, Lang D et al (2005) Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 167(6):1477\u20131484","journal-title":"Am J Pathol"},{"issue":"6","key":"3285_CR67","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1152\/japplphysiol.01298.2006","volume":"102","author":"TL Clanton","year":"2007","unstructured":"Clanton TL (2007) Hypoxia-induced reactive oxygen species formation in skeletal muscle. J Appl Physiol (1985) 102(6):2379\u20132388. https:\/\/doi.org\/10.1152\/japplphysiol.01298.2006","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"3285_CR68","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1080\/00039896.1970.10667244","volume":"21","author":"KW Cochran","year":"1970","unstructured":"Cochran KW, Maassab HF (1970) Inhibition of a cold variant of influenza virus by selected chemicals. Arch Environ Health 21(3):312\u2013315. https:\/\/doi.org\/10.1080\/00039896.1970.10667244","journal-title":"Arch Environ Health"},{"issue":"3","key":"3285_CR69","doi-asserted-by":"publisher","first-page":"e33258","DOI":"10.1371\/journal.pone.0033258","volume":"7","author":"E Conde","year":"2012","unstructured":"Conde E, Alegre L, Blanco-Sanchez I et al (2012) Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. PLoS ONE 7(3):e33258. https:\/\/doi.org\/10.1371\/journal.pone.0033258","journal-title":"PLoS ONE"},{"issue":"5","key":"3285_CR70","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/BF01973705","volume":"67","author":"F Courjault","year":"1993","unstructured":"Courjault F, Leroy D, Coquery L, Toutain H (1993) Platinum complex-induced dysfunction of cultured renal proximal tubule cells. A comparative study of carboplatin and transplatin with cisplatin. Arch Toxicol 67(5):338\u2013346. https:\/\/doi.org\/10.1007\/BF01973705","journal-title":"Arch Toxicol"},{"key":"3285_CR71","first-page":"1","volume-title":"Metal chelation in medicine. RSC metallobiology","author":"RR Crichton","year":"2017","unstructured":"Crichton RR (2017) Metal toxicity\u2014an introduction. In: Crichton R, Ward RJ, Hider RC (eds) Metal chelation in medicine. RSC metallobiology. The Royal Society of Chemistry, London, pp 1\u201323"},{"issue":"4","key":"3285_CR72","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1074\/jbc.M310404200","volume":"279","author":"C Dame","year":"2004","unstructured":"Dame C, Sola MC, Lim KC et al (2004) Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem 279(4):2955\u20132961. https:\/\/doi.org\/10.1074\/jbc.M310404200","journal-title":"J Biol Chem"},{"issue":"2","key":"3285_CR73","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/s0968-0004(98)01344-9","volume":"24","author":"CV Dang","year":"1999","unstructured":"Dang CV, Semenza GL (1999) Oncogenic alterations of metabolism. Trends Biochem Sci 24(2):68\u201372. https:\/\/doi.org\/10.1016\/s0968-0004(98)01344-9","journal-title":"Trends Biochem Sci"},{"issue":"Suppl","key":"3285_CR74","first-page":"S40","volume":"71","author":"PC Dartsch","year":"1998","unstructured":"Dartsch PC, Hildenbrand S, Kimmel R, Schmahl FW (1998) Investigations on the nephrotoxicity and hepatotoxicity of trivalent and hexavalent chromium compounds. Int Arch Occup Environ Health 71(Suppl):S40\u2013S45","journal-title":"Int Arch Occup Environ Health"},{"issue":"4","key":"3285_CR75","first-page":"412","volume":"128","author":"KK Das","year":"2008","unstructured":"Das KK, Das SN, Dhundasi SA (2008) Nickel, its adverse health effects & oxidative stress. Indian J Med Res 128(4):412\u2013425","journal-title":"Indian J Med Res"},{"key":"3285_CR76","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","volume":"740","author":"S Dasari","year":"2014","unstructured":"Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364\u2013378. https:\/\/doi.org\/10.1016\/j.ejphar.2014.07.025","journal-title":"Eur J Pharmacol"},{"issue":"1\u20132","key":"3285_CR77","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s11010-005-8288-y","volume":"279","author":"T Davidson","year":"2005","unstructured":"Davidson T, Chen H, Garrick MD, D\u2019Angelo G, Costa M (2005) Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem 279(1\u20132):157\u2013162. https:\/\/doi.org\/10.1007\/s11010-005-8288-y","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"3285_CR78","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/mc.20176","volume":"45","author":"TL Davidson","year":"2006","unstructured":"Davidson TL, Chen H, Di Toro DM, D\u2019Angelo G, Costa M (2006) Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog 45(7):479\u2013489. https:\/\/doi.org\/10.1002\/mc.20176","journal-title":"Mol Carcinog"},{"issue":"4 Pt 1","key":"3285_CR79","doi-asserted-by":"publisher","first-page":"C961","DOI":"10.1152\/ajpcell.1993.264.4.C961","volume":"264","author":"TL Dawson","year":"1993","unstructured":"Dawson TL, Gores GJ, Nieminen AL, Herman B, Lemasters JJ (1993) Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes. Am J Physiol 264(4 Pt 1):C961\u2013C967. https:\/\/doi.org\/10.1152\/ajpcell.1993.264.4.C961","journal-title":"Am J Physiol"},{"issue":"1","key":"3285_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10409238.2013.838205","volume":"49","author":"VL Dengler","year":"2014","unstructured":"Dengler VL, Galbraith M, Espinosa JM (2014) Transcriptional regulation by hypoxia inducible factors. Crit Rev Biochem Mol Biol 49(1):1\u201315. https:\/\/doi.org\/10.3109\/10409238.2013.838205","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"1","key":"3285_CR81","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s1040-8428(01)00214-1","volume":"42","author":"E Denkhaus","year":"2002","unstructured":"Denkhaus E, Salnikow K (2002) Nickel essentiality, toxicity, and carcinogenicity. Crit Rev Oncol Hematol 42(1):35\u201356. https:\/\/doi.org\/10.1016\/s1040-8428(01)00214-1","journal-title":"Crit Rev Oncol Hematol"},{"issue":"6","key":"3285_CR82","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00109-015-1276-0","volume":"93","author":"R Depping","year":"2015","unstructured":"Depping R, Jelkmann W, Kosyna FK (2015) Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing. J Mol Med 93(6):599\u2013608. https:\/\/doi.org\/10.1007\/s00109-015-1276-0","journal-title":"J Mol Med"},{"issue":"5","key":"3285_CR83","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40265-019-01077-1","volume":"79","author":"S Dhillon","year":"2019","unstructured":"Dhillon S (2019) Roxadustat: first global approval. Drugs 79(5):563\u2013572. https:\/\/doi.org\/10.1007\/s40265-019-01077-1","journal-title":"Drugs"},{"issue":"14","key":"3285_CR84","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s40265-020-01384-y","volume":"80","author":"S Dhillon","year":"2020","unstructured":"Dhillon S (2020) Daprodustat: first approval. Drugs 80(14):1491\u20131497. https:\/\/doi.org\/10.1007\/s40265-020-01384-y","journal-title":"Drugs"},{"key":"3285_CR85","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.freeradbiomed.2015.09.023","volume":"89","author":"P Diaz-Vivancos","year":"2015","unstructured":"Diaz-Vivancos P, de Simone A, Kiddle G, Foyer CH (2015) Glutathione\u2014linking cell proliferation to oxidative stress. Free Radic Biol Med 89:1154\u20131164. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.09.023","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"3285_CR86","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1089\/ars.2012.4886","volume":"20","author":"SI Dikalov","year":"2014","unstructured":"Dikalov SI, Harrison DG (2014) Methods for detection of mitochondrial and cellular reactive oxygen species. Antioxid Redox Signal 20(2):372\u2013382. https:\/\/doi.org\/10.1089\/ars.2012.4886","journal-title":"Antioxid Redox Signal"},{"key":"3285_CR87","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jtemb.2019.09.007","volume":"57","author":"D Dobritzsch","year":"2020","unstructured":"Dobritzsch D, Grancharov K, Hermsen C, Krauss GJ, Schaumloffel D (2020) Inhibitory effect of metals on animal and plant glutathione transferases. J Trace Elem Med Biol 57:48\u201356. https:\/\/doi.org\/10.1016\/j.jtemb.2019.09.007","journal-title":"J Trace Elem Med Biol"},{"key":"3285_CR88","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-1-4614-3573-0_6","volume":"748","author":"S Drose","year":"2012","unstructured":"Drose S, Brandt U (2012) Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Biol 748:145\u2013169. https:\/\/doi.org\/10.1007\/978-1-4614-3573-0_6","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"3285_CR89","doi-asserted-by":"publisher","first-page":"C260","DOI":"10.1152\/ajpcell.00315.2015","volume":"310","author":"C Duan","year":"2016","unstructured":"Duan C (2016) Hypoxia-inducible factor 3 biology: complexities and emerging themes. Am J Physiol Cell Physiol 310(4):C260\u2013C269. https:\/\/doi.org\/10.1152\/ajpcell.00315.2015","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"3285_CR90","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s42003-021-01653-w","volume":"4","author":"M Dufies","year":"2021","unstructured":"Dufies M, Verbiest A, Cooley LS et al (2021) Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol 4(1):166. https:\/\/doi.org\/10.1038\/s42003-021-01653-w","journal-title":"Commun Biol"},{"issue":"4","key":"3285_CR91","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/ki.1993.115","volume":"43","author":"KU Eckardt","year":"1993","unstructured":"Eckardt KU, Koury ST, Tan CC et al (1993) Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. Kidney Int 43(4):815\u2013823. https:\/\/doi.org\/10.1038\/ki.1993.115","journal-title":"Kidney Int"},{"issue":"Suppl. 99","key":"3285_CR92","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.1111\/j.1523-1755.2005.09909.x","volume":"68","author":"KU Eckardt","year":"2005","unstructured":"Eckardt KU, Bernhardt WM, Weidemann A et al (2005) Role of hypoxia in the pathogenesis of renal disease. Kidney Int 68 (Suppl. 99):S46\u2013S51. https:\/\/doi.org\/10.1111\/j.1523-1755.2005.09909.x","journal-title":"Kidney Int Suppl"},{"issue":"11","key":"3285_CR93","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1038\/mt.2011.162","volume":"19","author":"N Eliopoulos","year":"2011","unstructured":"Eliopoulos N, Zhao J, Forner K, Birman E, Young YK, Bouchentouf M (2011) Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice. Mol Ther 19(11):2072\u20132083. https:\/\/doi.org\/10.1038\/mt.2011.162","journal-title":"Mol Ther"},{"issue":"9","key":"3285_CR94","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1073\/pnas.94.9.4273","volume":"94","author":"M Ema","year":"1997","unstructured":"Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y (1997) A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 94(9):4273\u20134278. https:\/\/doi.org\/10.1073\/pnas.94.9.4273","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3285_CR95","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/s0092-8674(01)00507-4","volume":"107","author":"AC Epstein","year":"2001","unstructured":"Epstein AC, Gleadle JM, McNeill LA et al (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107(1):43\u201354. https:\/\/doi.org\/10.1016\/s0092-8674(01)00507-4","journal-title":"Cell"},{"issue":"5","key":"3285_CR96","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1172\/JCI17423","volume":"111","author":"V Eremina","year":"2003","unstructured":"Eremina V, Sood M, Haigh J et al (2003) Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Investig 111(5):707\u2013716. https:\/\/doi.org\/10.1172\/JCI17423","journal-title":"J Clin Investig"},{"issue":"11","key":"3285_CR97","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","volume":"358","author":"V Eremina","year":"2008","unstructured":"Eremina V, Jefferson JA, Kowalewska J et al (2008) VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358(11):1129\u20131136. https:\/\/doi.org\/10.1056\/NEJMoa0707330","journal-title":"N Engl J Med"},{"issue":"19","key":"3285_CR98","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1056\/NEJM199105093241907","volume":"324","author":"AJ Erslev","year":"1991","unstructured":"Erslev AJ (1991) Erythropoietin. N Engl J Med 324(19):1339\u20131344. https:\/\/doi.org\/10.1056\/NEJM199105093241907","journal-title":"N Engl J Med"},{"issue":"5","key":"3285_CR99","doi-asserted-by":"publisher","first-page":"F1259","DOI":"10.1152\/ajprenal.90230.2008","volume":"295","author":"RG Evans","year":"2008","unstructured":"Evans RG, Gardiner BS, Smith DW, O\u2019Connor PM (2008) Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis. Am J Physiol Renal Physiol 295(5):F1259\u2013F1270. https:\/\/doi.org\/10.1152\/ajprenal.90230.2008","journal-title":"Am J Physiol Renal Physiol"},{"issue":"10","key":"3285_CR100","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1093\/ndt\/gfaa091","volume":"36","author":"A Faivre","year":"2021","unstructured":"Faivre A, Scholz CC, de Seigneux S (2021) Hypoxia in chronic kidney disease: towards a paradigm shift? Nephrol Dial Transplant 36(10):1782\u20131790. https:\/\/doi.org\/10.1093\/ndt\/gfaa091","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"3285_CR101","doi-asserted-by":"publisher","first-page":"F803","DOI":"10.1152\/ajprenal.2001.280.5.F803","volume":"280","author":"CJ Ferguson","year":"2001","unstructured":"Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, Riccardi D (2001) Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol 280(5):F803\u2013F814. https:\/\/doi.org\/10.1152\/ajprenal.2001.280.5.F803","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"3285_CR102","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1749-6632.1968.tb15139.x","volume":"149","author":"JW Fisher","year":"1968","unstructured":"Fisher JW, Langston JW (1968) Effects of testosterone, cobalt and hypoxia on erythropoietin production in the isolated perfused dog kidney. Ann N Y Acad Sci 149(1):75\u201387. https:\/\/doi.org\/10.1111\/j.1749-6632.1968.tb15139.x","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"3285_CR103","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1042\/BJ20091609","volume":"427","author":"E Flashman","year":"2010","unstructured":"Flashman E, Davies SL, Yeoh KK, Schofield CJ (2010) Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J 427(1):135\u2013142. https:\/\/doi.org\/10.1042\/BJ20091609","journal-title":"Biochem J"},{"issue":"4","key":"3285_CR104","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4161\/oxim.2.4.9112","volume":"2","author":"SJ Flora","year":"2009","unstructured":"Flora SJ (2009) Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev 2(4):191\u2013206. https:\/\/doi.org\/10.4161\/oxim.2.4.9112","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"3285_CR105","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.3390\/ijerph7072745","volume":"7","author":"SJ Flora","year":"2010","unstructured":"Flora SJ, Pachauri V (2010) Chelation in metal intoxication. Int J Environ Res Public Health 7(7):2745\u20132788. https:\/\/doi.org\/10.3390\/ijerph7072745","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"3285_CR106","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/cdd.2008.10","volume":"15","author":"GH Fong","year":"2008","unstructured":"Fong GH, Takeda K (2008) Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ 15(4):635\u2013641. https:\/\/doi.org\/10.1038\/cdd.2008.10","journal-title":"Cell Death Differ"},{"issue":"9","key":"3285_CR107","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","volume":"20","author":"HJ Forman","year":"2021","unstructured":"Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 20(9):689\u2013709. https:\/\/doi.org\/10.1038\/s41573-021-00233-1","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"3285_CR108","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JA Forsythe","year":"1996","unstructured":"Forsythe JA, Jiang BH, Iyer NV et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9):4604\u20134613. https:\/\/doi.org\/10.1128\/MCB.16.9.4604","journal-title":"Mol Cell Biol"},{"issue":"4\u20135","key":"3285_CR109","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.mam.2005.07.013","volume":"26","author":"CG Fraga","year":"2005","unstructured":"Fraga CG (2005) Relevance, essentiality and toxicity of trace elements in human health. Mol Aspects Med 26(4\u20135):235\u2013244. https:\/\/doi.org\/10.1016\/j.mam.2005.07.013","journal-title":"Mol Aspects Med"},{"issue":"3","key":"3285_CR110","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0048-9697(88)90210-0","volume":"71","author":"I Franchini","year":"1988","unstructured":"Franchini I, Mutti A (1988) Selected toxicological aspects of chromium(VI) compounds. Sci Total Environ 71(3):379\u2013387. https:\/\/doi.org\/10.1016\/0048-9697(88)90210-0","journal-title":"Sci Total Environ"},{"issue":"6","key":"3285_CR111","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1089\/ars.2011.3999","volume":"15","author":"T Fukai","year":"2011","unstructured":"Fukai T, Ushio-Fukai M (2011) Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15(6):1583\u20131606. https:\/\/doi.org\/10.1089\/ars.2011.3999","journal-title":"Antioxid Redox Signal"},{"issue":"11\u201312","key":"3285_CR112","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1007\/s00018-016-2209-y","volume":"73","author":"L Galluzzi","year":"2016","unstructured":"Galluzzi L, Bravo-San Pedro JM, Kepp O, Kroemer G (2016) Regulated cell death and adaptive stress responses. Cell Mol Life Sci 73(11\u201312):2405\u20132410. https:\/\/doi.org\/10.1007\/s00018-016-2209-y","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"3285_CR113","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","volume":"93","author":"T Ganz","year":"2013","unstructured":"Ganz T (2013) Systemic iron homeostasis. Physiol Rev 93(4):1721\u20131741. https:\/\/doi.org\/10.1152\/physrev.00008.2013","journal-title":"Physiol Rev"},{"issue":"5","key":"3285_CR114","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.kint.2018.07.027","volume":"94","author":"T Ganz","year":"2018","unstructured":"Ganz T (2018) Erythropoietin and iron\u2014a conflicted alliance? Kidney Int 94(5):851\u2013853. https:\/\/doi.org\/10.1016\/j.kint.2018.07.027","journal-title":"Kidney Int"},{"issue":"2","key":"3285_CR115","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1093\/toxsci\/kfs327","volume":"132","author":"S Gao","year":"2013","unstructured":"Gao S, Zhou J, Zhao Y, Toselli P, Li W (2013) Hypoxia-response element (HRE)-directed transcriptional regulation of the rat lysyl oxidase gene in response to cobalt and cadmium. Toxicol Sci 132(2):379\u2013389. https:\/\/doi.org\/10.1093\/toxsci\/kfs327","journal-title":"Toxicol Sci"},{"issue":"3","key":"3285_CR116","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3390\/ijerph17030679","volume":"17","author":"G Genchi","year":"2020","unstructured":"Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A (2020) Nickel: human health and environmental toxicology. Int J Environ Res Public Health.\u00a017(3):679. https:\/\/doi.org\/10.3390\/ijerph17030679","journal-title":"Int J Environ Res Public Health"},{"issue":"8","key":"3285_CR117","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc.2017.52","volume":"17","author":"TW Glover","year":"2017","unstructured":"Glover TW, Wilson TE, Arlt MF (2017) Fragile sites in cancer: more than meets the eye. Nat Rev Cancer 17(8):489\u2013501. https:\/\/doi.org\/10.1038\/nrc.2017.52","journal-title":"Nat Rev Cancer"},{"issue":"4884","key":"3285_CR118","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1126\/science.2849206","volume":"242","author":"MA Goldberg","year":"1988","unstructured":"Goldberg MA, Dunning SP, Bunn HF (1988) Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242(4884):1412\u20131415. https:\/\/doi.org\/10.1126\/science.2849206","journal-title":"Science"},{"key":"3285_CR119","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev.pharmtox.010909.105600","volume":"50","author":"R Gozzelino","year":"2010","unstructured":"Gozzelino R, Jeney V, Soares MP (2010) Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol 50:323\u2013354. https:\/\/doi.org\/10.1146\/annurev.pharmtox.010909.105600","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"7","key":"3285_CR120","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1073\/pnas.0608382104","volume":"104","author":"M Gruber","year":"2007","unstructured":"Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC (2007) Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA 104(7):2301\u20132306. https:\/\/doi.org\/10.1073\/pnas.0608382104","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"3285_CR121","first-page":"205","volume":"7","author":"YZ Gu","year":"1998","unstructured":"Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA (1998) Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 7(3):205\u2013213","journal-title":"Gene Expr"},{"issue":"1","key":"3285_CR122","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0278-6915(88)90039-7","volume":"26","author":"M Gumbleton","year":"1988","unstructured":"Gumbleton M, Nicholls PJ (1988) Dose-response and time-response biochemical and histological study of potassium dichromate-induced nephrotoxicity in the rat. Food Chem Toxicol 26(1):37\u201344. https:\/\/doi.org\/10.1016\/0278-6915(88)90039-7","journal-title":"Food Chem Toxicol"},{"issue":"6641","key":"3285_CR123","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/41343","volume":"388","author":"H Gunshin","year":"1997","unstructured":"Gunshin H, Mackenzie B, Berger UV et al (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388(6641):482\u2013488. https:\/\/doi.org\/10.1038\/41343","journal-title":"Nature"},{"issue":"4","key":"3285_CR124","doi-asserted-by":"publisher","first-page":"776","DOI":"10.4252\/wjsc.v7.i4.776","volume":"7","author":"AK Gupta","year":"2015","unstructured":"Gupta AK, Jadhav SH, Tripathy NK, Nityanand S (2015) Fetal kidney stem cells ameliorate cisplatin induced acute renal failure and promote renal angiogenesis. World J Stem Cells 7(4):776\u2013788. https:\/\/doi.org\/10.4252\/wjsc.v7.i4.776","journal-title":"World J Stem Cells"},{"issue":"6","key":"3285_CR125","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","volume":"1","author":"RD Guzy","year":"2005","unstructured":"Guzy RD, Hoyos B, Robin E et al (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1(6):401\u2013408. https:\/\/doi.org\/10.1016\/j.cmet.2005.05.001","journal-title":"Cell Metab"},{"issue":"Suppl 1","key":"3285_CR126","doi-asserted-by":"publisher","first-page":"S110","DOI":"10.1111\/hdi.12567","volume":"21","author":"VH Haase","year":"2017","unstructured":"Haase VH (2017) HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism. Hemodial Int 21(Suppl 1):S110\u2013S124. https:\/\/doi.org\/10.1111\/hdi.12567","journal-title":"Hemodial Int"},{"issue":"1","key":"3285_CR127","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.kisu.2020.12.002","volume":"11","author":"VH Haase","year":"2021","unstructured":"Haase VH (2021) Hypoxia-inducible factor-prolyl hydroxylase inhibitors in the treatment of anemia of chronic kidney disease. Kidney Int Suppl 11(1):8\u201325. https:\/\/doi.org\/10.1016\/j.kisu.2020.12.002","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"3285_CR128","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/ndt\/gfy055","volume":"34","author":"VH Haase","year":"2019","unstructured":"Haase VH, Chertow GM, Block GA et al (2019) Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents. Nephrol Dial Transplant 34(1):90\u201399. https:\/\/doi.org\/10.1093\/ndt\/gfy055","journal-title":"Nephrol Dial Transplant"},{"issue":"14","key":"3285_CR129","first-page":"2946","volume":"58","author":"P Hadaczek","year":"1998","unstructured":"Hadaczek P, Siprashvili Z, Markiewski M et al (1998) Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res 58(14):2946\u20132951","journal-title":"Cancer Res"},{"issue":"5652","key":"3285_CR130","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1126\/science.1088805","volume":"302","author":"T Hagen","year":"2003","unstructured":"Hagen T, Taylor CT, Lam F, Moncada S (2003) Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 302(5652):1975\u20131978. https:\/\/doi.org\/10.1126\/science.1088805","journal-title":"Science"},{"issue":"3C","key":"3285_CR131","doi-asserted-by":"publisher","first-page":"14S","DOI":"10.1016\/0002-9343(91)90279-7","volume":"91","author":"B Halliwell","year":"1991","unstructured":"Halliwell B (1991) Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 91(3C):14S-22S. https:\/\/doi.org\/10.1016\/0002-9343(91)90279-7","journal-title":"Am J Med"},{"issue":"3","key":"3285_CR132","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tips.2010.12.002","volume":"32","author":"B Halliwell","year":"2011","unstructured":"Halliwell B (2011) Free radicals and antioxidants\u2014quo vadis? Trends Pharmacol Sci 32(3):125\u2013130. https:\/\/doi.org\/10.1016\/j.tips.2010.12.002","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"3285_CR133","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2217\/epi.15.24","volume":"7","author":"RL Hancock","year":"2015","unstructured":"Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A (2015) Epigenetic regulation by histone demethylases in hypoxia. Epigenomics 7(5):791\u2013811. https:\/\/doi.org\/10.2217\/epi.15.24","journal-title":"Epigenomics"},{"issue":"4","key":"3285_CR134","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1006\/bbrc.2001.5659","volume":"287","author":"S Hara","year":"2001","unstructured":"Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun 287(4):808\u2013813. https:\/\/doi.org\/10.1006\/bbrc.2001.5659","journal-title":"Biochem Biophys Res Commun"},{"key":"3285_CR135","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/978-94-007-5179-8_15","volume":"11","author":"A Hartwig","year":"2013","unstructured":"Hartwig A (2013) Cadmium and cancer. Met Ions Life Sci 11:491\u2013507. https:\/\/doi.org\/10.1007\/978-94-007-5179-8_15","journal-title":"Met Ions Life Sci"},{"key":"3285_CR136","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1201\/9781315380476","volume-title":"CRC handbook of chemistry and physics","author":"WM Haynes","year":"2016","unstructured":"Haynes WM, Lide DR, Bruno TJ (2016) Abundance of elements in the Earth\u2019s crust and in the sea. CRC handbook of chemistry and physics, 97th edn. CRC Press, Boca Raton, pp 14\u201317","edition":"97"},{"issue":"5","key":"3285_CR137","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","volume":"116","author":"M Hayyan","year":"2016","unstructured":"Hayyan M, Hashim MA, AlNashef IM (2016) Superoxide Ion: Generation and Chemical Implications. Chem Rev 116(5):3029\u20133085. https:\/\/doi.org\/10.1021\/acs.chemrev.5b00407","journal-title":"Chem Rev"},{"issue":"1","key":"3285_CR138","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","volume":"142","author":"MW Hentze","year":"2010","unstructured":"Hentze MW, Muckenthaler MU, Galy B, Camaschella C (2010) Two to tango: regulation of Mammalian iron metabolism. Cell 142(1):24\u201338. https:\/\/doi.org\/10.1016\/j.cell.2010.06.028","journal-title":"Cell"},{"issue":"2","key":"3285_CR139","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/cc9991","volume":"15","author":"SN Heyman","year":"2011","unstructured":"Heyman SN, Rosen S, Rosenberger C (2011) Hypoxia-inducible factors and the prevention of acute organ injury. Crit Care 15(2):209. https:\/\/doi.org\/10.1186\/cc9991","journal-title":"Crit Care"},{"issue":"2","key":"3285_CR140","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1006\/taap.1996.0076","volume":"137","author":"H Hiratsuka","year":"1996","unstructured":"Hiratsuka H, Katsuta O, Toyota N, Tsuchitani M, Umemura T, Marumo F (1996) Chronic cadmium exposure-induced renal anemia in ovariectomized rats. Toxicol Appl Pharmacol 137(2):228\u2013236. https:\/\/doi.org\/10.1006\/taap.1996.0076","journal-title":"Toxicol Appl Pharmacol"},{"issue":"12","key":"3285_CR141","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.3390\/ijms20123011","volume":"20","author":"SJ Holditch","year":"2019","unstructured":"Holditch SJ, Brown CN, Lombardi AM, Nguyen KN, Edelstein CL (2019) Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury. Int J Mol Sci 20(12):3011. https:\/\/doi.org\/10.3390\/ijms20123011","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3285_CR142","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1681\/ASN.2014111139","volume":"27","author":"L Holdstock","year":"2016","unstructured":"Holdstock L, Meadowcroft AM, Maier R et al (2016) Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia. J Am Soc Nephrol 27(4):1234\u20131244. https:\/\/doi.org\/10.1681\/ASN.2014111139","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3285_CR143","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ccr.2006.08.026","volume":"10","author":"L Holmquist-Mengelbier","year":"2006","unstructured":"Holmquist-Mengelbier L, Fredlund E, Lofstedt T et al (2006) Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 10(5):413\u2013423. https:\/\/doi.org\/10.1016\/j.ccr.2006.08.026","journal-title":"Cancer Cell"},{"issue":"2","key":"3285_CR144","first-page":"299","volume":"43","author":"SM Hopfer","year":"1984","unstructured":"Hopfer SM, Sunderman FW Jr, Reid MC, Goldwasser E (1984) Increased immunoreactive erythropoietin in serum and kidney extracts. Res Commun Chem Pathol Pharmacol 43(2):299\u2013305","journal-title":"Res Commun Chem Pathol Pharmacol"},{"issue":"5","key":"3285_CR145","first-page":"425","volume":"10","author":"E Horak","year":"1980","unstructured":"Horak E, Sunderman FW Jr (1980) Nephrotoxicity of nickel carbonyl in rats. Ann Clin Lab Sci 10(5):425\u2013431","journal-title":"Ann Clin Lab Sci"},{"issue":"1\u20132","key":"3285_CR146","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s002040050352","volume":"71","author":"H Horiguchi","year":"1996","unstructured":"Horiguchi H, Sato M, Konno N, Fukushima M (1996) Long-term cadmium exposure induces anemia in rats through hypoinduction of erythropoietin in the kidneys. Arch Toxicol 71(1\u20132):11\u201319. https:\/\/doi.org\/10.1007\/s002040050352","journal-title":"Arch Toxicol"},{"issue":"12","key":"3285_CR147","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1182\/blood.V96.12.3743","volume":"96","author":"H Horiguchi","year":"2000","unstructured":"Horiguchi H, Kayama F, Oguma E, Willmore WG, Hradecky P, Bunn HF (2000) Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications. Blood 96(12):3743\u20133747","journal-title":"Blood"},{"issue":"10","key":"3285_CR148","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s00204-006-0093-1","volume":"80","author":"H Horiguchi","year":"2006","unstructured":"Horiguchi H, Oguma E, Kayama F (2006) Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells. Arch Toxicol 80(10):680\u2013686. https:\/\/doi.org\/10.1007\/s00204-006-0093-1","journal-title":"Arch Toxicol"},{"issue":"1","key":"3285_CR149","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/toxsci\/kfr100","volume":"122","author":"H Horiguchi","year":"2011","unstructured":"Horiguchi H, Oguma E, Kayama F (2011) Cadmium induces anemia through interdependent progress of hemolysis, body iron accumulation, and insufficient erythropoietin production in rats. Toxicol Sci 122(1):198\u2013210. https:\/\/doi.org\/10.1093\/toxsci\/kfr100","journal-title":"Toxicol Sci"},{"issue":"11","key":"3285_CR150","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/gcc.22097","volume":"52","author":"SA Hosseini","year":"2013","unstructured":"Hosseini SA, Horton S, Saldivar JC et al (2013) Common chromosome fragile sites in human and murine epithelial cells and FHIT\/FRA3B loss-induced global genome instability. Genes Chromosomes Cancer 52(11):1017\u20131029. https:\/\/doi.org\/10.1002\/gcc.22097","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"3285_CR151","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s12013-014-9922-7","volume":"70","author":"MJ Hosseini","year":"2014","unstructured":"Hosseini MJ, Shaki F, Ghazi-Khansari M, Pourahmad J (2014) Toxicity of copper on isolated liver mitochondria: impairment at complexes I, II, and IV leads to increased ROS production. Cell Biochem Biophys 70(1):367\u2013381. https:\/\/doi.org\/10.1007\/s12013-014-9922-7","journal-title":"Cell Biochem Biophys"},{"issue":"8","key":"3285_CR152","doi-asserted-by":"publisher","first-page":"F1149","DOI":"10.1152\/ajprenal.00275.2013","volume":"305","author":"J Hou","year":"2013","unstructured":"Hou J, Cai S, Kitajima Y et al (2013) 5-Aminolevulinic acid combined with ferrous iron induces carbon monoxide generation in mouse kidneys and protects from renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 305(8):F1149\u2013F1157. https:\/\/doi.org\/10.1152\/ajprenal.00275.2013","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"3285_CR153","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1128\/MCB.26.9.3514-3526.2006","volume":"26","author":"CJ Hu","year":"2006","unstructured":"Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC (2006) Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol 26(9):3514\u20133526. https:\/\/doi.org\/10.1128\/MCB.26.9.3514-3526.2006","journal-title":"Mol Cell Biol"},{"issue":"1\u20132","key":"3285_CR154","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.mrfmmm.2003.08.023","volume":"533","author":"X Huang","year":"2003","unstructured":"Huang X (2003) Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res 533(1\u20132):153\u2013171","journal-title":"Mutat Res"},{"issue":"50","key":"3285_CR155","doi-asserted-by":"publisher","first-page":"32253","DOI":"10.1074\/jbc.271.50.32253","volume":"271","author":"LE Huang","year":"1996","unstructured":"Huang LE, Arany Z, Livingston DM, Bunn HF (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271(50):32253\u201332259. https:\/\/doi.org\/10.1074\/jbc.271.50.32253","journal-title":"J Biol Chem"},{"issue":"2","key":"3285_CR156","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/ki.1997.76","volume":"51","author":"LE Huang","year":"1997","unstructured":"Huang LE, Ho V, Arany Z et al (1997) Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors. Kidney Int 51(2):548\u2013552. https:\/\/doi.org\/10.1038\/ki.1997.76","journal-title":"Kidney Int"},{"issue":"3","key":"3285_CR157","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/35106058","volume":"1","author":"K Huebner","year":"2001","unstructured":"Huebner K, Croce CM (2001) FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer 1(3):214\u2013221. https:\/\/doi.org\/10.1038\/35106058","journal-title":"Nat Rev Cancer"},{"issue":"36","key":"3285_CR158","doi-asserted-by":"publisher","first-page":"30485","DOI":"10.1074\/jbc.M112.364208","volume":"287","author":"AC Illing","year":"2012","unstructured":"Illing AC, Shawki A, Cunningham CL, Mackenzie B (2012) Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. J Biol Chem 287(36):30485\u201330496. https:\/\/doi.org\/10.1074\/jbc.M112.364208","journal-title":"J Biol Chem"},{"issue":"4","key":"3285_CR159","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/BF02982127","volume":"75","author":"S Imagawa","year":"2002","unstructured":"Imagawa S, Suzuki N, Ohmine K et al (2002) GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter. Int J Hematol 75(4):376\u2013381. https:\/\/doi.org\/10.1007\/BF02982127","journal-title":"Int J Hematol"},{"key":"3285_CR160","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/82_2010_74","volume":"345","author":"HZ Imtiyaz","year":"2010","unstructured":"Imtiyaz HZ, Simon MC (2010) Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol 345:105\u2013120. https:\/\/doi.org\/10.1007\/82_2010_74","journal-title":"Curr Top Microbiol Immunol"},{"issue":"5516","key":"3285_CR161","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1126\/science.1059817","volume":"292","author":"M Ivan","year":"2001","unstructured":"Ivan M, Kondo K, Yang H et al (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292(5516):464\u2013468. https:\/\/doi.org\/10.1126\/science.1059817","journal-title":"Science"},{"issue":"5516","key":"3285_CR162","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola P, Mole DR, Tian YM et al (2001) Targeting of HIF-alpha to the von Hippel\u2013Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292(5516):468\u2013472. https:\/\/doi.org\/10.1126\/science.1059796","journal-title":"Science"},{"issue":"3","key":"3285_CR163","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/toxics6030053","volume":"6","author":"T Jacobo-Estrada","year":"2018","unstructured":"Jacobo-Estrada T, Cardenas-Gonzalez M, Santoyo-Sanchez MP, Th\u00e9venod F, Barbier O (2018) Intrauterine exposure to cadmium reduces HIF-1 DNA-binding ability in rat fetal kidneys. Toxics 6(3):53. https:\/\/doi.org\/10.3390\/toxics6030053","journal-title":"Toxics"},{"key":"3285_CR164","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1146\/annurev.ph.48.030186.003415","volume":"48","author":"D Jamieson","year":"1986","unstructured":"Jamieson D, Chance B, Cadenas E, Boveris A (1986) The relation of free radical production to hyperoxia. Annu Rev Physiol 48:703\u2013719. https:\/\/doi.org\/10.1146\/annurev.ph.48.030186.003415","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"3285_CR165","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/toxsci\/kfr256","volume":"125","author":"Y Jing","year":"2012","unstructured":"Jing Y, Liu LZ, Jiang Y et al (2012) Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. Toxicol Sci 125(1):10\u201319. https:\/\/doi.org\/10.1093\/toxsci\/kfr256","journal-title":"Toxicol Sci"},{"issue":"8","key":"3285_CR166","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.freeradbiomed.2007.01.026","volume":"42","author":"M Kaczmarek","year":"2007","unstructured":"Kaczmarek M, Timofeeva OA, Karaczyn A, Malyguine A, Kasprzak KS, Salnikow K (2007) The role of ascorbate in the modulation of HIF-1alpha protein and HIF-dependent transcription by chromium(VI) and nickel(II). Free Radic Biol Med 42(8):1246\u20131257. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.01.026","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"3285_CR167","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/toxsci\/kfn251","volume":"107","author":"M Kaczmarek","year":"2009","unstructured":"Kaczmarek M, Cachau RE, Topol IA, Kasprzak KS, Ghio A, Salnikow K (2009) Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Toxicol Sci 107(2):394\u2013403. https:\/\/doi.org\/10.1093\/toxsci\/kfn251","journal-title":"Toxicol Sci"},{"key":"3285_CR168","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev.biochem.74.082803.133142","volume":"74","author":"WG Kaelin","year":"2005","unstructured":"Kaelin WG (2005) Proline hydroxylation and gene expression. Annu Rev Biochem 74:115\u2013128. https:\/\/doi.org\/10.1146\/annurev.biochem.74.082803.133142","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"3285_CR169","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/cdd.2017.179","volume":"25","author":"H Kalkavan","year":"2018","unstructured":"Kalkavan H, Green DR (2018) MOMP, cell suicide as a BCL-2 family business. Cell Death Differ 25(1):46\u201355. https:\/\/doi.org\/10.1038\/cdd.2017.179","journal-title":"Cell Death Differ"},{"issue":"11","key":"3285_CR170","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/gtc.12537","volume":"22","author":"H Kaneko","year":"2017","unstructured":"Kaneko H, Katoh T, Hirano I et al (2017) Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes Cells 22(11):939\u2013952. https:\/\/doi.org\/10.1111\/gtc.12537","journal-title":"Genes Cells"},{"issue":"16","key":"3285_CR171","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1182\/blood-2010-02-270322","volume":"116","author":"PP Kapitsinou","year":"2010","unstructured":"Kapitsinou PP, Liu Q, Unger TL et al (2010) Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 116(16):3039\u20133048. https:\/\/doi.org\/10.1182\/blood-2010-02-270322","journal-title":"Blood"},{"issue":"6","key":"3285_CR172","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1172\/JCI69073","volume":"124","author":"PP Kapitsinou","year":"2014","unstructured":"Kapitsinou PP, Sano H, Michael M et al (2014) Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury. J Clin Invest 124(6):2396\u20132409. https:\/\/doi.org\/10.1172\/JCI69073","journal-title":"J Clin Invest"},{"issue":"5","key":"3285_CR173","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1002\/jcb.20705","volume":"97","author":"A Karaczyn","year":"2006","unstructured":"Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak KS, Salnikow K (2006) Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J Cell Biochem 97(5):1025\u20131035. https:\/\/doi.org\/10.1002\/jcb.20705","journal-title":"J Cell Biochem"},{"issue":"3","key":"3285_CR174","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.toxlet.2015.06.012","volume":"237","author":"T Karasawa","year":"2015","unstructured":"Karasawa T, Steyger PS (2015) An integrated view of cisplatin-induced nephrotoxicity and ototoxicity. Toxicol Lett 237(3):219\u2013227. https:\/\/doi.org\/10.1016\/j.toxlet.2015.06.012","journal-title":"Toxicol Lett"},{"issue":"1","key":"3285_CR175","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1172\/JCI86418","volume":"127","author":"LS Keir","year":"2017","unstructured":"Keir LS, Firth R, Aponik L et al (2017) VEGF regulates local inhibitory complement proteins in the eye and kidney. J Clin Investig 127(1):199\u2013214. https:\/\/doi.org\/10.1172\/JCI86418","journal-title":"J Clin Investig"},{"issue":"4","key":"3285_CR176","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/iub.1990","volume":"71","author":"F Khadangi","year":"2019","unstructured":"Khadangi F, Azzi A (2019) Vitamin E\u2014the next 100 years. IUBMB Life 71(4):411\u2013415. https:\/\/doi.org\/10.1002\/iub.1990","journal-title":"IUBMB Life"},{"issue":"9","key":"3285_CR177","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.3390\/ijms18091854","volume":"18","author":"JY Kim","year":"2017","unstructured":"Kim JY, Lee JY (2017) Targeting tumor adaption to chronic hypoxia: implications for drug resistance, and how it can be overcome. Int J Mol Sci 18(9):1854. https:\/\/doi.org\/10.3390\/ijms18091854","journal-title":"Int J Mol Sci"},{"key":"3285_CR178","volume-title":"Casarett and Doull's toxicology: the basic science of poisons","author":"CD Klaassen","year":"2019","unstructured":"Klaassen CD (2019) Casarett and Doull\u2019s toxicology: the basic science of poisons, 9th edn. McGraw-Hill, New York","edition":"9"},{"issue":"4","key":"3285_CR179","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/sj.cdd.4402307","volume":"15","author":"T Klimova","year":"2008","unstructured":"Klimova T, Chandel NS (2008) Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ 15(4):660\u2013666. https:\/\/doi.org\/10.1038\/sj.cdd.4402307","journal-title":"Cell Death Differ"},{"issue":"5","key":"3285_CR180","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1172\/JCI83551","volume":"126","author":"H Kobayashi","year":"2016","unstructured":"Kobayashi H, Liu Q, Binns TC et al (2016) Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Investig 126(5):1926\u20131938. https:\/\/doi.org\/10.1172\/JCI83551","journal-title":"J Clin Investig"},{"issue":"1","key":"3285_CR181","doi-asserted-by":"publisher","first-page":"219","DOI":"10.5301\/jn.5000177","volume":"26","author":"D Kong","year":"2013","unstructured":"Kong D, Zhuo L, Gao C et al (2013) Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis. J Nephrol 26(1):219\u2013227. https:\/\/doi.org\/10.5301\/jn.5000177","journal-title":"J Nephrol"},{"issue":"2","key":"3285_CR182","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1182\/blood.V74.2.645.645","volume":"74","author":"ST Koury","year":"1989","unstructured":"Koury ST, Koury MJ, Bondurant MC, Caro J, Graber SE (1989) Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood 74(2):645\u2013651","journal-title":"Blood"},{"issue":"1","key":"3285_CR183","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1128\/MCB.00444-09","volume":"30","author":"AJ Krieg","year":"2010","unstructured":"Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ (2010) Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol 30(1):344\u2013353. https:\/\/doi.org\/10.1128\/MCB.00444-09","journal-title":"Mol Cell Biol"},{"issue":"2","key":"3285_CR184","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1159\/000084575","volume":"100","author":"Y Kudo","year":"2005","unstructured":"Kudo Y, Kakinuma Y, Mori Y et al (2005) Hypoxia-inducible factor-1alpha is involved in the attenuation of experimentally induced rat glomerulonephritis. Nephron Exp Nephrol 100(2):e95-103. https:\/\/doi.org\/10.1159\/000084575","journal-title":"Nephron Exp Nephrol"},{"issue":"6","key":"3285_CR185","doi-asserted-by":"publisher","first-page":"R455","DOI":"10.1152\/ajpregu.00568.2013","volume":"308","author":"B Kurt","year":"2015","unstructured":"Kurt B, Kurtz A (2015) Plasticity of renal endocrine function. Am J Physiol Regul Integr Comp Physiol 308(6):R455\u2013R466. https:\/\/doi.org\/10.1152\/ajpregu.00568.2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"12","key":"3285_CR186","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1101\/gad.991402","volume":"16","author":"D Lando","year":"2002","unstructured":"Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002a) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev 16(12):1466\u20131471. https:\/\/doi.org\/10.1101\/gad.991402","journal-title":"Genes Dev"},{"issue":"5556","key":"3285_CR187","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1126\/science.1068592","volume":"295","author":"D Lando","year":"2002","unstructured":"Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002b) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295(5556):858\u2013861. https:\/\/doi.org\/10.1126\/science.1068592","journal-title":"Science"},{"issue":"5","key":"3285_CR188","doi-asserted-by":"publisher","first-page":"F871","DOI":"10.1152\/ajprenal.00388.2016","volume":"311","author":"DE Leaf","year":"2016","unstructured":"Leaf DE, Swinkels DW (2016) Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol 311(5):F871\u2013F876. https:\/\/doi.org\/10.1152\/ajprenal.00388.2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"3285_CR189","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00204-020-02692-8","volume":"94","author":"WK Lee","year":"2020","unstructured":"Lee WK, Th\u00e9venod F (2020) Cell organelles as targets of mammalian cadmium toxicity. Arch Toxicol 94:1017\u20131049. https:\/\/doi.org\/10.1007\/s00204-020-02692-8","journal-title":"Arch Toxicol"},{"issue":"9","key":"3285_CR190","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","volume":"272","author":"PJ Lee","year":"1997","unstructured":"Lee PJ, Jiang BH, Chin BY et al (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 272(9):5375\u20135381","journal-title":"J Biol Chem"},{"issue":"6","key":"3285_CR191","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2174\/138920009789375360","volume":"10","author":"WK Lee","year":"2009","unstructured":"Lee WK, Wolff NA, Th\u00e9venod F (2009) Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab 10(6):617\u2013631","journal-title":"Curr Drug Metab"},{"key":"3285_CR192","doi-asserted-by":"publisher","first-page":"18928","DOI":"10.1038\/srep18928","volume":"6","author":"G Lee","year":"2016","unstructured":"Lee G, Won HS, Lee YM et al (2016) Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1alpha activation. Sci Rep 6:18928. https:\/\/doi.org\/10.1038\/srep18928","journal-title":"Sci Rep"},{"issue":"5","key":"3285_CR193","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","volume":"21","author":"P Lee","year":"2020","unstructured":"Lee P, Chandel NS, Simon MC (2020) Cellular adaptation to hypoxia through hypoxia inducible factors and beyond. Nat Rev Mol Cell Biol 21(5):268\u2013283. https:\/\/doi.org\/10.1038\/s41580-020-0227-y","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"3285_CR194","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/cod.12969","volume":"78","author":"T Lejding","year":"2018","unstructured":"Lejding T, Mowitz M, Isaksson M et al (2018) A retrospective investigation of hexavalent chromium allergy in southern Sweden. Contact Dermatitis 78(6):386\u2013392. https:\/\/doi.org\/10.1111\/cod.12969","journal-title":"Contact Dermatitis"},{"key":"3285_CR195","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1289\/ehp.751073","volume":"10","author":"AF LeRoy","year":"1975","unstructured":"LeRoy AF (1975) Interactions of platinum metals and their complexes in biological systems. Environ Health Perspect 10:73\u201383. https:\/\/doi.org\/10.1289\/ehp.751073","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3285_CR196","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1089\/ars.2016.6659","volume":"25","author":"JM Lever","year":"2016","unstructured":"Lever JM, Boddu R, George JF, Agarwal A (2016) Heme oxygenase-1 in kidney health and disease. Antioxid Redox Signal 25(3):165\u2013183. https:\/\/doi.org\/10.1089\/ars.2016.6659","journal-title":"Antioxid Redox Signal"},{"key":"3285_CR197","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tox.2017.05.015","volume":"387","author":"L Leyssens","year":"2017","unstructured":"Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L (2017) Cobalt toxicity in humans-A review of the potential sources and systemic health effects. Toxicology 387:43\u201356. https:\/\/doi.org\/10.1016\/j.tox.2017.05.015","journal-title":"Toxicology"},{"issue":"3","key":"3285_CR198","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.taap.2005.11.006","volume":"213","author":"Q Li","year":"2006","unstructured":"Li Q, Chen H, Huang X, Costa M (2006) Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245\u2013255. https:\/\/doi.org\/10.1016\/j.taap.2005.11.006","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"3285_CR199","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/2211-5463.12760","volume":"10","author":"Q Li","year":"2020","unstructured":"Li Q, Liang X, Yang Y, Zeng X, Zhong X, Huang C (2020) Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1alpha\/mitochondria\/ROS pathway. FEBS Open Bio 10(1):118\u2013126. https:\/\/doi.org\/10.1002\/2211-5463.12760","journal-title":"FEBS Open Bio"},{"issue":"2","key":"3285_CR200","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3390\/cancers13020180","volume":"13","author":"S Li","year":"2021","unstructured":"Li S, Wen L, Hu X, Wei Q, Dong Z (2021) HIF in nephrotoxicity during cisplatin chemotherapy: regulation, function and therapeutic potential. Cancers (basel) 13(2):180. https:\/\/doi.org\/10.3390\/cancers13020180","journal-title":"Cancers (basel)"},{"issue":"4","key":"3285_CR201","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1139\/o02-115","volume":"80","author":"ME Lieb","year":"2002","unstructured":"Lieb ME, Menzies K, Moschella MC, Ni R, Taubman MB (2002) Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem Cell Biol 80(4):421\u2013426. https:\/\/doi.org\/10.1139\/o02-115","journal-title":"Biochem Cell Biol"},{"issue":"1\u20132","key":"3285_CR202","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.mrgentox.2008.09.015","volume":"674","author":"J Limon-Pacheco","year":"2009","unstructured":"Limon-Pacheco J, Gonsebatt ME (2009) The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutat Res 674(1\u20132):137\u2013147. https:\/\/doi.org\/10.1016\/j.mrgentox.2008.09.015","journal-title":"Mutat Res"},{"issue":"1","key":"3285_CR203","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1073\/pnas.0706585104","volume":"105","author":"X Lin","year":"2008","unstructured":"Lin X, David CA, Donnelly JB et al (2008) A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation. Proc Natl Acad Sci USA 105(1):174\u2013179. https:\/\/doi.org\/10.1073\/pnas.0706585104","journal-title":"Proc Natl Acad Sci USA"},{"key":"3285_CR204","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2018.02.022","volume":"48","author":"TJ Lin","year":"2018","unstructured":"Lin TJ, Huang YL, Chang JS et al (2018) Optimal dosage and early intervention of l-ascorbic acid inhibiting K2Cr2O7-induced renal tubular cell damage. J Trace Elem Med Biol 48:1\u20137. https:\/\/doi.org\/10.1016\/j.jtemb.2018.02.022","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"3285_CR205","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.semcancer.2012.06.002","volume":"23","author":"WM Linehan","year":"2013","unstructured":"Linehan WM, Ricketts CJ (2013) The metabolic basis of kidney cancer. Semin Cancer Biol 23(1):46\u201355. https:\/\/doi.org\/10.1016\/j.semcancer.2012.06.002","journal-title":"Semin Cancer Biol"},{"issue":"13","key":"3285_CR206","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1158\/1078-0432.CCR-13-0304","volume":"19","author":"WM Linehan","year":"2013","unstructured":"Linehan WM, Rouault TA (2013) Molecular pathways: fumarate hydratase-deficient kidney cancer\u2014targeting the Warburg effect in cancer. Clin Cancer Res 19(13):3345\u20133352. https:\/\/doi.org\/10.1158\/1078-0432.CCR-13-0304","journal-title":"Clin Cancer Res"},{"issue":"5","key":"3285_CR207","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nrurol.2010.47","volume":"7","author":"WM Linehan","year":"2010","unstructured":"Linehan WM, Srinivasan R, Schmidt LS (2010) The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 7(5):277\u2013285. https:\/\/doi.org\/10.1038\/nrurol.2010.47","journal-title":"Nat Rev Urol"},{"issue":"8","key":"3285_CR208","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1158\/2159-8290.CD-18-1354","volume":"9","author":"WM Linehan","year":"2019","unstructured":"Linehan WM, Schmidt LS, Crooks DR et al (2019) The metabolic basis of kidney cancer. Cancer Discov 9(8):1006\u20131021. https:\/\/doi.org\/10.1158\/2159-8290.CD-18-1354","journal-title":"Cancer Discov"},{"issue":"47","key":"3285_CR209","doi-asserted-by":"publisher","first-page":"16836","DOI":"10.1073\/pnas.1415518111","volume":"111","author":"A Linkermann","year":"2014","unstructured":"Linkermann A, Skouta R, Himmerkus N et al (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci USA 111(47):16836\u201316841. https:\/\/doi.org\/10.1073\/pnas.1415518111","journal-title":"Proc Natl Acad Sci USA"},{"key":"3285_CR210","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.canlet.2017.02.025","volume":"394","author":"W Liu","year":"2017","unstructured":"Liu W, Chen H, Wong N, Haynes W, Baker CM, Wang X (2017) Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Cancer Lett 394:65\u201375. https:\/\/doi.org\/10.1016\/j.canlet.2017.02.025","journal-title":"Cancer Lett"},{"issue":"1","key":"3285_CR211","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.tibs.2010.07.002","volume":"36","author":"C Loenarz","year":"2011","unstructured":"Loenarz C, Schofield CJ (2011) Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci 36(1):7\u201318. https:\/\/doi.org\/10.1016\/j.tibs.2010.07.002","journal-title":"Trends Biochem Sci"},{"issue":"4","key":"3285_CR212","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10661-017-5886-6","volume":"189","author":"G Lopez-Rodriguez","year":"2017","unstructured":"Lopez-Rodriguez G, Galvan M, Gonzalez-Unzaga M, Hernandez Avila J, Perez-Labra M (2017) Blood toxic metals and hemoglobin levels in Mexican children. Environ Monit Assess 189(4):179. https:\/\/doi.org\/10.1007\/s10661-017-5886-6","journal-title":"Environ Monit Assess"},{"key":"3285_CR213","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1196\/annals.1391.010","volume":"1113","author":"MA Lynes","year":"2007","unstructured":"Lynes MA, Kang YJ, Sensi SL, Perdrizet GA, Hightower LE (2007) Heavy metal ions in normal physiology, toxic stress, and cytoprotection. Ann N Y Acad Sci 1113:159\u2013172. https:\/\/doi.org\/10.1196\/annals.1391.010","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"3285_CR214","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cmet.2005.05.003","volume":"1","author":"KD Mansfield","year":"2005","unstructured":"Mansfield KD, Guzy RD, Pan Y et al (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1(6):393\u2013399. https:\/\/doi.org\/10.1016\/j.cmet.2005.05.003","journal-title":"Cell Metab"},{"issue":"13","key":"3285_CR215","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s40265-020-01383-z","volume":"80","author":"A Markham","year":"2020","unstructured":"Markham A (2020) Vadadustat: first approval. Drugs 80(13):1365\u20131371. https:\/\/doi.org\/10.1007\/s40265-020-01383-z","journal-title":"Drugs"},{"issue":"5","key":"3285_CR216","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1159\/000464476","volume":"45","author":"ER Martin","year":"2017","unstructured":"Martin ER, Smith MT, Maroni BJ, Zuraw QC, deGoma EM (2017) Clinical trial of vadadustat in patients with anemia secondary to stage 3 or 4 chronic kidney disease. Am J Nephrol 45(5):380\u2013388. https:\/\/doi.org\/10.1159\/000464476","journal-title":"Am J Nephrol"},{"issue":"1","key":"3285_CR217","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","volume":"21","author":"JC Martinou","year":"2011","unstructured":"Martinou JC, Youle RJ (2011) Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21(1):92\u2013101. https:\/\/doi.org\/10.1016\/j.devcel.2011.06.017","journal-title":"Dev Cell"},{"issue":"7","key":"3285_CR218","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1097\/01.asn.0000074239.22357.06","volume":"14","author":"M Matsumoto","year":"2003","unstructured":"Matsumoto M, Makino Y, Tanaka T et al (2003) Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 14(7):1825\u20131832. https:\/\/doi.org\/10.1097\/01.asn.0000074239.22357.06","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3285_CR219","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4161\/cbt.3.1.547","volume":"3","author":"P Maxwell","year":"2004","unstructured":"Maxwell P, Salnikow K (2004) HIF-1: an oxygen and metal responsive transcription factor. Cancer Biol Ther 3(1):29\u201335. https:\/\/doi.org\/10.4161\/cbt.3.1.547","journal-title":"Cancer Biol Ther"},{"issue":"5","key":"3285_CR220","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/ki.1993.362","volume":"44","author":"PH Maxwell","year":"1993","unstructured":"Maxwell PH, Osmond MK, Pugh CW et al (1993) Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney Int 44(5):1149\u20131162. https:\/\/doi.org\/10.1038\/ki.1993.362","journal-title":"Kidney Int"},{"issue":"6733","key":"3285_CR221","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"PH Maxwell","year":"1999","unstructured":"Maxwell PH, Wiesener MS, Chang GW et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399(6733):271\u2013275. https:\/\/doi.org\/10.1038\/20459","journal-title":"Nature"},{"issue":"2","key":"3285_CR222","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ceb.2009.11.015","volume":"22","author":"NM Mazure","year":"2010","unstructured":"Mazure NM, Pouyssegur J (2010) Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol 22(2):177\u2013180. https:\/\/doi.org\/10.1016\/j.ceb.2009.11.015","journal-title":"Curr Opin Cell Biol"},{"issue":"4","key":"3285_CR223","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1039\/b511249b","volume":"1","author":"LA McNeill","year":"2005","unstructured":"McNeill LA, Flashman E, Buck MR et al (2005) Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Mol Biosyst 1(4):321\u2013324. https:\/\/doi.org\/10.1039\/b511249b","journal-title":"Mol Biosyst"},{"issue":"7","key":"3285_CR224","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.3390\/cancers13071572","volume":"13","author":"KR McSweeney","year":"2021","unstructured":"McSweeney KR, Gadanec LK, Qaradakhi T, Ali BA, Zulli A, Apostolopoulos V (2021) Mechanisms of cisplatin-induced acute kidney injury: pathological mechanisms, pharmacological interventions, and genetic mitigations. Cancers (basel) 13(7):1572. https:\/\/doi.org\/10.3390\/cancers13071572","journal-title":"Cancers (basel)"},{"issue":"4","key":"3285_CR225","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/cmdc.200700233","volume":"3","author":"J Mecinovic","year":"2008","unstructured":"Mecinovic J, Chowdhury R, Lienard BM et al (2008) ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site. ChemMedChem 3(4):569\u2013572. https:\/\/doi.org\/10.1002\/cmdc.200700233","journal-title":"ChemMedChem"},{"issue":"Pt 7","key":"3285_CR226","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1242\/jcs.00318","volume":"116","author":"E Metzen","year":"2003","unstructured":"Metzen E, Berchner-Pfannschmidt U, Stengel P et al (2003) Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J Cell Sci 116(Pt 7):1319\u20131326. https:\/\/doi.org\/10.1242\/jcs.00318","journal-title":"J Cell Sci"},{"issue":"1\u20132","key":"3285_CR227","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.etp.2011.08.006","volume":"65","author":"HE Mohamed","year":"2013","unstructured":"Mohamed HE, El-Swefy SE, Mohamed RH, Ghanim AM (2013) Effect of erythropoietin therapy on the progression of cisplatin induced renal injury in rats. Exp Toxicol Pathol 65(1\u20132):197\u2013203. https:\/\/doi.org\/10.1016\/j.etp.2011.08.006","journal-title":"Exp Toxicol Pathol"},{"issue":"1","key":"3285_CR228","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2110-5820-1-3","volume":"1","author":"E Moore","year":"2011","unstructured":"Moore E, Bellomo R (2011) Erythropoietin (EPO) in acute kidney injury. Ann Intensive Care 1(1):3. https:\/\/doi.org\/10.1186\/2110-5820-1-3","journal-title":"Ann Intensive Care"},{"key":"3285_CR229","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1471-2407-13-14","volume":"13","author":"C Morais","year":"2013","unstructured":"Morais C, Johnson DW, Vesey DA, Gobe GC (2013) Functional significance of erythropoietin in renal cell carcinoma. BMC Cancer 13:14. https:\/\/doi.org\/10.1186\/1471-2407-13-14","journal-title":"BMC Cancer"},{"issue":"5","key":"3285_CR230","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1093\/emboj\/cdg117","volume":"22","author":"M Morita","year":"2003","unstructured":"Morita M, Ohneda O, Yamashita T et al (2003) HLF\/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J 22(5):1134\u20131146. https:\/\/doi.org\/10.1093\/emboj\/cdg117","journal-title":"EMBO J"},{"issue":"5","key":"3285_CR231","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s10534-010-9365-6","volume":"23","author":"JM Moulis","year":"2010","unstructured":"Moulis JM, Th\u00e9venod F (2010) New perspectives in cadmium toxicity: an introduction. Biometals 23(5):763\u2013768. https:\/\/doi.org\/10.1007\/s10534-010-9365-6","journal-title":"Biometals"},{"issue":"10","key":"3285_CR232","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/j.1432-2277.2007.00538.x","volume":"20","author":"MR Moussavian","year":"2007","unstructured":"Moussavian MR, Slotta JE, Kollmar O, Menger MD, Schilling MK, Gronow G (2007) Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules. Transpl Int 20(10):884\u2013894. https:\/\/doi.org\/10.1111\/j.1432-2277.2007.00538.x","journal-title":"Transpl Int"},{"issue":"Pt 7","key":"3285_CR233","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1242\/jeb.132142","volume":"220","author":"D Munro","year":"2017","unstructured":"Munro D, Treberg JR (2017) A radical shift in perspective: mitochondria as regulators of reactive oxygen species. J Exp Biol 220(Pt 7):1170\u20131180. https:\/\/doi.org\/10.1242\/jeb.132142","journal-title":"J Exp Biol"},{"issue":"2","key":"3285_CR234","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbrc.2014.05.014","volume":"449","author":"T Nagai","year":"2014","unstructured":"Nagai T, Yasuoka Y, Izumi Y et al (2014) Reevaluation of erythropoietin production by the nephron. Biochem Biophys Res Commun 449(2):222\u2013228. https:\/\/doi.org\/10.1016\/j.bbrc.2014.05.014","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"3285_CR235","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00109-007-0278-y","volume":"85","author":"M Nangaku","year":"2007","unstructured":"Nangaku M, Eckardt KU (2007) Hypoxia and the HIF system in kidney disease. J Mol Med 85(12):1325\u20131330. https:\/\/doi.org\/10.1007\/s00109-007-0278-y","journal-title":"J Mol Med"},{"issue":"4","key":"3285_CR236","doi-asserted-by":"publisher","first-page":"387","DOI":"10.23876\/j.krcp.20.091","volume":"39","author":"M Nath","year":"2020","unstructured":"Nath M, Agarwal A (2020) New insights into the role of heme oxygenase-1 in acute kidney injury. Kidney Res Clin Pract 39(4):387\u2013401. https:\/\/doi.org\/10.23876\/j.krcp.20.091","journal-title":"Kidney Res Clin Pract"},{"issue":"1","key":"3285_CR237","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1172\/JCI115847","volume":"90","author":"KA Nath","year":"1992","unstructured":"Nath KA, Balla G, Vercellotti GM et al (1992) Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Investig 90(1):267\u2013270. https:\/\/doi.org\/10.1172\/JCI115847","journal-title":"J Clin Investig"},{"issue":"2","key":"3285_CR238","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.kint.2016.08.023","volume":"91","author":"M Nezu","year":"2017","unstructured":"Nezu M, Souma T, Yu L et al (2017) Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney Int 91(2):387\u2013401. https:\/\/doi.org\/10.1016\/j.kint.2016.08.023","journal-title":"Kidney Int"},{"issue":"6","key":"3285_CR239","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/0306-3623(81)90078-1","volume":"12","author":"EO Ngaha","year":"1981","unstructured":"Ngaha EO (1981) Renal effects of potassium dichromate in the rat: comparison of urinary enzyme excretion with corresponding tissue patterns. Gen Pharmacol 12(6):497\u2013500. https:\/\/doi.org\/10.1016\/0306-3623(81)90078-1","journal-title":"Gen Pharmacol"},{"key":"3285_CR240","doi-asserted-by":"publisher","first-page":"108960","DOI":"10.1016\/j.abb.2021.108960","volume":"708","author":"K Nishimura","year":"2021","unstructured":"Nishimura K, Iitaka S, Nakagawa H (2021) Effect of trivalent chromium on erythropoietin production and the prevention of insulin resistance in HepG2 cells. Arch Biochem Biophys 708:108960. https:\/\/doi.org\/10.1016\/j.abb.2021.108960","journal-title":"Arch Biochem Biophys"},{"issue":"8966","key":"3285_CR241","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/s0140-6736(95)92648-8","volume":"346","author":"GD Nuyts","year":"1995","unstructured":"Nuyts GD, Van Vlem E, Thys J et al (1995) New occupational risk factors for chronic renal failure. Lancet 346(8966):7\u201311. https:\/\/doi.org\/10.1016\/s0140-6736(95)92648-8","journal-title":"Lancet"},{"issue":"5","key":"3285_CR242","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00204-003-0444-0","volume":"77","author":"N Obara","year":"2003","unstructured":"Obara N, Imagawa S, Nakano Y, Suzuki N, Yamamoto M, Nagasawa T (2003) Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2. Arch Toxicol 77(5):267\u2013273. https:\/\/doi.org\/10.1007\/s00204-003-0444-0","journal-title":"Arch Toxicol"},{"issue":"10","key":"3285_CR243","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1182\/blood-2007-10-115857","volume":"111","author":"N Obara","year":"2008","unstructured":"Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M (2008) Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood 111(10):5223\u20135232. https:\/\/doi.org\/10.1182\/blood-2007-10-115857","journal-title":"Blood"},{"issue":"6","key":"3285_CR244","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1080\/009841099157593","volume":"57","author":"E Obone","year":"1999","unstructured":"Obone E, Chakrabarti SK, Bai C, Malick MA, Lamontagne L, Subramanian KS (1999) Toxicity and bioaccumulation of nickel sulfate in Sprague-Dawley rats following 13 weeks of subchronic exposure. J Toxicol Environ Health A 57(6):379\u2013401. https:\/\/doi.org\/10.1080\/009841099157593","journal-title":"J Toxicol Environ Health A"},{"issue":"5","key":"3285_CR245","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/labinvest.2017.11","volume":"97","author":"K Oshima","year":"2017","unstructured":"Oshima K, Ikeda Y, Horinouchi Y et al (2017) Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation. Lab Investig 97(5):555\u2013566. https:\/\/doi.org\/10.1038\/labinvest.2017.11","journal-title":"Lab Investig"},{"issue":"4","key":"3285_CR246","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/ki.2009.460","volume":"77","author":"A Paliege","year":"2010","unstructured":"Paliege A, Rosenberger C, Bondke A et al (2010) Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization. Kidney Int 77(4):312\u2013318. https:\/\/doi.org\/10.1038\/ki.2009.460","journal-title":"Kidney Int"},{"issue":"1","key":"3285_CR247","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/tox.20395","volume":"24","author":"AK Patlolla","year":"2009","unstructured":"Patlolla AK, Barnes C, Yedjou C, Velma VR, Tchounwou PB (2009) Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol 24(1):66\u201373. https:\/\/doi.org\/10.1002\/tox.20395","journal-title":"Environ Toxicol"},{"key":"3285_CR248","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2369-6-4","volume":"6","author":"J Pedraza-Chaverri","year":"2005","unstructured":"Pedraza-Chaverri J, Barrera D, Medina-Campos ON et al (2005) Time course study of oxidative and nitrosative stress and antioxidant enzymes in K2Cr2O7-induced nephrotoxicity. BMC Nephrol 6:4. https:\/\/doi.org\/10.1186\/1471-2369-6-4","journal-title":"BMC Nephrol"},{"issue":"5","key":"3285_CR249","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.kint.2016.07.019","volume":"90","author":"PE Pergola","year":"2016","unstructured":"Pergola PE, Spinowitz BS, Hartman CS, Maroni BJ, Haase VH (2016) Vadadustat, a novel oral HIF stabilizer, provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int 90(5):1115\u20131122. https:\/\/doi.org\/10.1016\/j.kint.2016.07.019","journal-title":"Kidney Int"},{"issue":"5\u20136","key":"3285_CR250","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/s0006-2952(02)01155-3","volume":"64","author":"JP Piret","year":"2002","unstructured":"Piret JP, Mottet D, Raes M, Michiels C (2002) Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol 64(5\u20136):889\u2013892. https:\/\/doi.org\/10.1016\/s0006-2952(02)01155-3","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"3285_CR251","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1042\/BJ20081238","volume":"416","author":"PJ Pollard","year":"2008","unstructured":"Pollard PJ, Loenarz C, Mole DR et al (2008) Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J 416(3):387\u2013394. https:\/\/doi.org\/10.1042\/BJ20081238","journal-title":"Biochem J"},{"issue":"6","key":"3285_CR252","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1053\/j.ajkd.2015.12.020","volume":"67","author":"R Provenzano","year":"2016","unstructured":"Provenzano R, Besarab A, Wright S et al (2016) Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: a phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study. Am J Kidney Dis 67(6):912\u2013924. https:\/\/doi.org\/10.1053\/j.ajkd.2015.12.020","journal-title":"Am J Kidney Dis"},{"issue":"8","key":"3285_CR253","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1021\/acs.chemrestox.9b00204","volume":"32","author":"L Qi","year":"2019","unstructured":"Qi L, Luo Q, Zhang Y, Jia F, Zhao Y, Wang F (2019) Advances in toxicological research of the anticancer drug cisplatin. Chem Res Toxicol 32(8):1469\u20131486. https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00204","journal-title":"Chem Res Toxicol"},{"issue":"4","key":"3285_CR254","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1172\/JCI30117","volume":"117","author":"EB Rankin","year":"2007","unstructured":"Rankin EB, Biju MP, Liu Q et al (2007) Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117(4):1068\u20131077. https:\/\/doi.org\/10.1172\/JCI30117","journal-title":"J Clin Invest"},{"issue":"4","key":"3285_CR255","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2113\/GSELEMENTS.4.4.259%JElements","volume":"4","author":"S Rauch","year":"2008","unstructured":"Rauch S, Morrison GM (2008) Environmental relevance of the platinum-group elements. Elements 4(4):259\u2013263. https:\/\/doi.org\/10.2113\/GSELEMENTS.4.4.259%JElements","journal-title":"Elements"},{"issue":"5","key":"3285_CR256","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1177\/1091581810411931","volume":"30","author":"K Rjiba-Touati","year":"2011","unstructured":"Rjiba-Touati K, Boussema IA, Belarbia A, Achour A, Bacha H (2011) Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney. Int J Toxicol 30(5):510\u2013517. https:\/\/doi.org\/10.1177\/1091581810411931","journal-title":"Int J Toxicol"},{"issue":"6","key":"3285_CR257","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/S0021-9258(18)96186-7","volume":"242","author":"B Rosenberg","year":"1967","unstructured":"Rosenberg B, Van Camp L, Grimley EB, Thomson AJ (1967) The inhibition of growth or cell division in Escherichia coli by different ionic species of platinum(IV) complexes. J Biol Chem 242(6):1347\u20131352","journal-title":"J Biol Chem"},{"issue":"5191","key":"3285_CR258","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/222385a0","volume":"222","author":"B Rosenberg","year":"1969","unstructured":"Rosenberg B, VanCamp L, Trosko JE, Mansour VH (1969) Platinum compounds: a new class of potent antitumour agents. Nature 222(5191):385\u2013386. https:\/\/doi.org\/10.1038\/222385a0","journal-title":"Nature"},{"issue":"7","key":"3285_CR259","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1097\/01.asn.0000017223.49823.2a","volume":"13","author":"C Rosenberger","year":"2002","unstructured":"Rosenberger C, Mandriota S, Jurgensen JS et al (2002) Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 13(7):1721\u20131732. https:\/\/doi.org\/10.1097\/01.asn.0000017223.49823.2a","journal-title":"J Am Soc Nephrol"},{"issue":"1\u20132","key":"3285_CR260","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/s0378-1119(02)01049-1","volume":"299","author":"F Rossignol","year":"2002","unstructured":"Rossignol F, Vache C, Clottes E (2002) Natural antisense transcripts of hypoxia-inducible factor 1alpha are detected in different normal and tumour human tissues. Gene 299(1\u20132):135\u2013140. https:\/\/doi.org\/10.1016\/s0378-1119(02)01049-1","journal-title":"Gene"},{"key":"3285_CR261","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3389\/fphar.2019.00740","volume":"10","author":"A Rubio-Navarro","year":"2019","unstructured":"Rubio-Navarro A, Vazquez-Carballo C, Guerrero-Hue M et al (2019) Nrf2 plays a protective role against intravascular hemolysis-mediated acute kidney injury. Front Pharmacol 10:740. https:\/\/doi.org\/10.3389\/fphar.2019.00740","journal-title":"Front Pharmacol"},{"issue":"3","key":"3285_CR262","doi-asserted-by":"publisher","first-page":"p107","DOI":"10.1159\/000095539","volume":"104","author":"I Sabolic","year":"2006","unstructured":"Sabolic I (2006) Common mechanisms in nephropathy induced by toxic metals. Nephron Physiol 104(3):p107\u2013p114. https:\/\/doi.org\/10.1159\/000095539","journal-title":"Nephron Physiol"},{"issue":"9","key":"3285_CR263","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1093\/carcin\/20.9.1819","volume":"20","author":"K Salnikow","year":"1999","unstructured":"Salnikow K, An WG, Melillo G, Blagosklonny MV, Costa M (1999) Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Carcinogenesis 20(9):1819\u20131823. https:\/\/doi.org\/10.1093\/carcin\/20.9.1819","journal-title":"Carcinogenesis"},{"issue":"1","key":"3285_CR264","first-page":"38","volume":"60","author":"K Salnikow","year":"2000","unstructured":"Salnikow K, Blagosklonny MV, Ryan H, Johnson R, Costa M (2000a) Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res 60(1):38\u201341","journal-title":"Cancer Res"},{"issue":"13","key":"3285_CR265","first-page":"3375","volume":"60","author":"K Salnikow","year":"2000","unstructured":"Salnikow K, Su W, Blagosklonny MV, Costa M (2000b) Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism. Cancer Res 60(13):3375\u20133378","journal-title":"Cancer Res"},{"issue":"39","key":"3285_CR266","doi-asserted-by":"publisher","first-page":"40337","DOI":"10.1074\/jbc.M403057200","volume":"279","author":"K Salnikow","year":"2004","unstructured":"Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS (2004) Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 279(39):40337\u201340344. https:\/\/doi.org\/10.1074\/jbc.M403057200","journal-title":"J Biol Chem"},{"issue":"12","key":"3285_CR267","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","volume":"1833","author":"R Sano","year":"2013","unstructured":"Sano R, Reed JC (2013) ER stress-induced cell death mechanisms. Biochim Biophys Acta 1833(12):3460\u20133470. https:\/\/doi.org\/10.1016\/j.bbamcr.2013.06.028","journal-title":"Biochim Biophys Acta"},{"key":"3285_CR268","doi-asserted-by":"publisher","unstructured":"Satarug S, G CG, D AV, Phelps KR (2020) Cadmium and Lead Exposure, Nephrotoxicity, and Mortality. Toxics 8(4):86. doi:https:\/\/doi.org\/10.3390\/toxics8040086","DOI":"10.3390\/toxics8040086"},{"issue":"8","key":"3285_CR269","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/ng.2699","volume":"45","author":"Y Sato","year":"2013","unstructured":"Sato Y, Yoshizato T, Shiraishi Y et al (2013) Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 45(8):860\u2013867. https:\/\/doi.org\/10.1038\/ng.2699","journal-title":"Nat Genet"},{"issue":"8","key":"3285_CR270","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1080\/1071576021000005267","volume":"36","author":"GJ Schaaf","year":"2002","unstructured":"Schaaf GJ, Maas RF, de Groene EM, Fink-Gremmels J (2002) Management of oxidative stress by heme oxygenase-1 in cisplatin-induced toxicity in renal tubular cells. Free Radical Res 36(8):835\u2013843. https:\/\/doi.org\/10.1080\/1071576021000005267","journal-title":"Free Radical Res"},{"issue":"11","key":"3285_CR271","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1681\/ASN.2010121249","volume":"22","author":"G Schley","year":"2011","unstructured":"Schley G, Klanke B, Schodel J et al (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol 22(11):2004\u20132015. https:\/\/doi.org\/10.1681\/ASN.2010121249","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"3285_CR272","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.kint.2019.02.016","volume":"96","author":"G Schley","year":"2019","unstructured":"Schley G, Klanke B, Kalucka J et al (2019) Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis. Kidney Int 96(2):378\u2013396. https:\/\/doi.org\/10.1016\/j.kint.2019.02.016","journal-title":"Kidney Int"},{"issue":"10","key":"3285_CR273","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","volume":"15","author":"J Schodel","year":"2019","unstructured":"Schodel J, Ratcliffe PJ (2019) Mechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol 15(10):641\u2013659. https:\/\/doi.org\/10.1038\/s41581-019-0182-z","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"3285_CR274","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.2353\/ajpath.2009.080687","volume":"174","author":"J Schodel","year":"2009","unstructured":"Schodel J, Klanke B, Weidemann A et al (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol 174(5):1663\u20131674. https:\/\/doi.org\/10.2353\/ajpath.2009.080687","journal-title":"Am J Pathol"},{"issue":"9","key":"3285_CR275","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ki.2010.284","volume":"78","author":"J Schodel","year":"2010","unstructured":"Schodel J, Bohr D, Klanke B et al (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int 78(9):857\u2013867. https:\/\/doi.org\/10.1038\/ki.2010.284","journal-title":"Kidney Int"},{"issue":"1","key":"3285_CR276","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1093\/toxsci\/kfi117","volume":"85","author":"G Schwerdt","year":"2005","unstructured":"Schwerdt G, Freudinger R, Schuster C, Weber F, Thews O, Gekle M (2005) Cisplatin-induced apoptosis is enhanced by hypoxia and by inhibition of mitochondria in renal collecting duct cells. Toxicol Sci 85(1):735\u2013742. https:\/\/doi.org\/10.1093\/toxsci\/kfi117","journal-title":"Toxicol Sci"},{"issue":"1","key":"3285_CR277","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.semnephrol.2018.10.006","volume":"39","author":"DY Scindia Ph","year":"2019","unstructured":"Scindia Ph DY, Leeds MdJ, Swaminathan MdS (2019) Iron Homeostasis in Healthy Kidney and its Role in Acute Kidney Injury. Semin Nephrol 39(1):76\u201384. https:\/\/doi.org\/10.1016\/j.semnephrol.2018.10.006","journal-title":"Semin Nephrol"},{"issue":"2","key":"3285_CR278","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/biof.1476","volume":"45","author":"A Scire","year":"2019","unstructured":"Scire A, Cianfruglia L, Minnelli C et al (2019) Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways. BioFactors 45(2):152\u2013168. https:\/\/doi.org\/10.1002\/biof.1476","journal-title":"BioFactors"},{"issue":"8","key":"3285_CR279","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1182\/blood-2004-05-1695","volume":"105","author":"M Scortegagna","year":"2005","unstructured":"Scortegagna M, Ding K, Zhang Q et al (2005) HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood 105(8):3133\u20133140. https:\/\/doi.org\/10.1182\/blood-2004-05-1695","journal-title":"Blood"},{"issue":"10","key":"3285_CR280","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1128\/MCB.21.10.3436-3444.2001","volume":"21","author":"TN Seagroves","year":"2001","unstructured":"Seagroves TN, Ryan HE, Lu H et al (2001) Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol 21(10):3436\u20133444. https:\/\/doi.org\/10.1128\/MCB.21.10.3436-3444.2001","journal-title":"Mol Cell Biol"},{"issue":"6","key":"3285_CR281","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1038\/ki.1994.213","volume":"45","author":"G Seiken","year":"1994","unstructured":"Seiken G, Grillo FG, Schaudies RP, Johnson JP (1994) Modulation of renal EGF in dichromate-induced acute renal failure treated with thyroid hormone. Kidney Int 45(6):1622\u20131627. https:\/\/doi.org\/10.1038\/ki.1994.213","journal-title":"Kidney Int"},{"issue":"12","key":"3285_CR282","doi-asserted-by":"publisher","first-page":"5447","DOI":"10.1128\/mcb.12.12.5447-5454.1992","volume":"12","author":"GL Semenza","year":"1992","unstructured":"Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12(12):5447\u20135454. https:\/\/doi.org\/10.1128\/mcb.12.12.5447-5454.1992","journal-title":"Mol Cell Biol"},{"issue":"3","key":"3285_CR283","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1053\/j.gastro.2013.12.031","volume":"146","author":"YM Shah","year":"2014","unstructured":"Shah YM, Xie L (2014) Hypoxia-inducible factors link iron homeostasis and erythropoiesis. Gastroenterology 146(3):630\u2013642. https:\/\/doi.org\/10.1053\/j.gastro.2013.12.031","journal-title":"Gastroenterology"},{"issue":"632","key":"3285_CR284","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1136\/pgmj.54.632.414","volume":"54","author":"BK Sharma","year":"1978","unstructured":"Sharma BK, Singhal PC, Chugh KS (1978) Intravascular haemolysis and acute renal failure following potassium dichromate poisoning. Postgrad Med J 54(632):414\u2013415. https:\/\/doi.org\/10.1136\/pgmj.54.632.414","journal-title":"Postgrad Med J"},{"issue":"5","key":"3285_CR285","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2174\/1871520621666210805150705","volume":"22","author":"R Sharma","year":"2022","unstructured":"Sharma R, Singh VJ, Chawla PA (2022) Advancements in the Use of Platinum Complexes as Anticancer Agents. Anticancer Agents Med Chem. 22(5):821-835. https:\/\/doi.org\/10.2174\/1871520621666210805150705","journal-title":"Anticancer Agents Med Chem"},{"issue":"10","key":"3285_CR286","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207423","volume":"14","author":"X Shen","year":"2019","unstructured":"Shen X, Chi Y, Xiong K (2019) The effect of heavy metal contamination on humans and animals in the vicinity of a zinc smelting facility. PLoS ONE 14(10):e0207423. https:\/\/doi.org\/10.1371\/journal.pone.0207423","journal-title":"PLoS ONE"},{"issue":"4","key":"3285_CR287","doi-asserted-by":"publisher","first-page":"374","DOI":"10.21147\/j.issn.1000-9604.2017.04.11","volume":"29","author":"N Shenoy","year":"2017","unstructured":"Shenoy N, Dronca R, Quevedo F et al (2017) Low hypoxia inducible factor-1alpha (HIF-1alpha) expression in testicular germ cell tumors - a major reason for enhanced chemosensitivity? Chin J Cancer Res 29(4):374\u2013378. https:\/\/doi.org\/10.21147\/j.issn.1000-9604.2017.04.11","journal-title":"Chin J Cancer Res"},{"issue":"22","key":"3285_CR288","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1093\/jnci\/90.22.1720","volume":"90","author":"YH Shiao","year":"1998","unstructured":"Shiao YH, Rice JM, Anderson LM, Diwan BA, Hard GC (1998) von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors. J Natl Cancer Inst 90(22):1720\u20131723. https:\/\/doi.org\/10.1093\/jnci\/90.22.1720","journal-title":"J Natl Cancer Inst"},{"issue":"1\u20132","key":"3285_CR289","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0304-3835(02)00407-x","volume":"187","author":"YH Shiao","year":"2002","unstructured":"Shiao YH, Kamata SI, Li LM et al (2002) Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors. Cancer Lett 187(1\u20132):207\u2013214. https:\/\/doi.org\/10.1016\/s0304-3835(02)00407-x","journal-title":"Cancer Lett"},{"issue":"10","key":"3285_CR290","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009092","volume":"5","author":"M Shibuya","year":"2013","unstructured":"Shibuya M (2013) VEGFR and type-V RTK activation and signaling. Cold Spring Harb Perspect Biol 5(10):a009092. https:\/\/doi.org\/10.1101\/cshperspect.a009092","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"3285_CR291","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1097\/00003246-200003000-00033","volume":"28","author":"H Shimizu","year":"2000","unstructured":"Shimizu H, Takahashi T, Suzuki T et al (2000) Protective effect of heme oxygenase induction in ischemic acute renal failure. Crit Care Med 28(3):809\u2013817","journal-title":"Crit Care Med"},{"issue":"5","key":"3285_CR292","doi-asserted-by":"publisher","first-page":"F726","DOI":"10.1152\/ajprenal.2000.278.5.F726","volume":"278","author":"F Shiraishi","year":"2000","unstructured":"Shiraishi F, Curtis LM, Truong L et al (2000) Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol 278(5):F726\u2013F736. https:\/\/doi.org\/10.1152\/ajprenal.2000.278.5.F726","journal-title":"Am J Physiol Renal Physiol"},{"issue":"11","key":"3285_CR293","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/sj.onc.1201100","volume":"14","author":"V Shridhar","year":"1997","unstructured":"Shridhar V, Wang L, Rosati R et al (1997) Frequent breakpoints in the region surrounding FRA3B in sporadic renal cell carcinomas. Oncogene 14(11):1269\u20131277. https:\/\/doi.org\/10.1038\/sj.onc.1201100","journal-title":"Oncogene"},{"issue":"3","key":"3285_CR294","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3390\/cells8030207","volume":"8","author":"S Shu","year":"2019","unstructured":"Shu S, Wang Y, Zheng M et al (2019) Hypoxia and hypoxia-inducible factors in kidney injury and repair. Cells 8(3):207. https:\/\/doi.org\/10.3390\/cells8030207","journal-title":"Cells"},{"key":"3285_CR295","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/B978-0-12-395499-2.50015-3","volume-title":"chelating agents and metal chelates","author":"A Shulman","year":"1964","unstructured":"Shulman A, Dwyer FP (1964) Metal chelates in biological systems. In: Dwyer FP, Mellor DP (eds) chelating agents and metal chelates. Academic Press, New York, pp 383\u2013439"},{"issue":"8","key":"3285_CR296","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/j.1365-2036.2012.05051.x","volume":"35","author":"A Siddique","year":"2012","unstructured":"Siddique A, Kowdley KV (2012) Review article: the iron overload syndromes. Aliment Pharmacol Ther 35(8):876\u2013893. https:\/\/doi.org\/10.1111\/j.1365-2036.2012.05051.x","journal-title":"Aliment Pharmacol Ther"},{"key":"3285_CR297","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.scitotenv.2012.06.009","volume":"432","author":"LO Simonsen","year":"2012","unstructured":"Simonsen LO, Harbak H, Bennekou P (2012) Cobalt metabolism and toxicology\u2013a brief update. The Science of the Total Environment 432:210\u2013215. https:\/\/doi.org\/10.1016\/j.scitotenv.2012.06.009","journal-title":"The Science of the Total Environment"},{"issue":"2","key":"3285_CR298","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1039\/c4mt00225c","volume":"7","author":"RJ Simpson","year":"2015","unstructured":"Simpson RJ, McKie AT (2015) Iron and oxygen sensing: a tale of 2 interacting elements? Metallomics Integr Biomet Sci 7(2):223\u2013231. https:\/\/doi.org\/10.1039\/c4mt00225c","journal-title":"Metallomics Integr Biomet Sci"},{"issue":"11","key":"3285_CR299","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1681\/ASN.2015010052","volume":"26","author":"I Slotki","year":"2015","unstructured":"Slotki I, Cabantchik ZI (2015) The Labile Side of Iron Supplementation in CKD. J Am Soc Nephrol 26(11):2612\u20132619. https:\/\/doi.org\/10.1681\/ASN.2015010052","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"3285_CR300","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s13181-013-0343-6","volume":"9","author":"SW Smith","year":"2013","unstructured":"Smith SW (2013) The role of chelation in the treatment of other metal poisonings. J Med Toxicol 9(4):355\u2013369. https:\/\/doi.org\/10.1007\/s13181-013-0343-6","journal-title":"J Med Toxicol"},{"issue":"7","key":"3285_CR301","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.bbagen.2008.10.010","volume":"1790","author":"CP Smith","year":"2009","unstructured":"Smith CP, Th\u00e9venod F (2009) Iron transport and the kidney. Biochim Biophys Acta 1790(7):724\u2013730. https:\/\/doi.org\/10.1016\/j.bbagen.2008.10.010","journal-title":"Biochim Biophys Acta"},{"key":"3285_CR302","first-page":"571","volume-title":"The environmental geochemistry of mineral deposits part A: processes, techniques, and health issues. Reviews in economic geology","author":"KS Smith","year":"1999","unstructured":"Smith KS, Huyck HLO (1999) An overview of the abundance, relative mobility, bioavailability, and human toxicity of metals. In: Plumlee GS, Logdson MJ (eds) The environmental geochemistry of mineral deposits part A: processes, techniques, and health issues. Reviews in economic geology, vol 6. Society of Economic Geologists Inc, Littleton, p 571"},{"issue":"6","key":"3285_CR303","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1365-2559.2005.02280.x","volume":"47","author":"EJ Soilleux","year":"2005","unstructured":"Soilleux EJ, Turley H, Tian YM, Pugh CW, Gatter KC, Harris AL (2005) Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology 47(6):602\u2013610. https:\/\/doi.org\/10.1111\/j.1365-2559.2005.02280.x","journal-title":"Histopathology"},{"issue":"4","key":"3285_CR304","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.ecoenv.2009.10.002","volume":"73","author":"N Soudani","year":"2010","unstructured":"Soudani N, Sefi M, Ben Amara I, Boudawara T, Zeghal N (2010) Protective effects of Selenium (Se) on Chromium (VI) induced nephrotoxicity in adult rats. Ecotoxicol Environ Saf 73(4):671\u2013678. https:\/\/doi.org\/10.1016\/j.ecoenv.2009.10.002","journal-title":"Ecotoxicol Environ Saf"},{"issue":"9","key":"3285_CR305","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1177\/0960327110387454","volume":"30","author":"N Soudani","year":"2011","unstructured":"Soudani N, Sefi M, Bouaziz H, Chtourou Y, Boudawara T, Zeghal N (2011) Nephrotoxicity induced by chromium (VI) in adult rats and their progeny. Hum Exp Toxicol 30(9):1233\u20131245. https:\/\/doi.org\/10.1177\/0960327110387454","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"3285_CR306","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1681\/ASN.2014121184","volume":"27","author":"T Souma","year":"2016","unstructured":"Souma T, Nezu M, Nakano D et al (2016) Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. J Am Soc Nephrol 27(2):428\u2013438. https:\/\/doi.org\/10.1681\/ASN.2014121184","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"3285_CR307","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1093\/carcin\/12.9.1733","volume":"12","author":"AM Standeven","year":"1991","unstructured":"Standeven AM, Wetterhahn KE (1991) Ascorbate is the principal reductant of chromium (VI) in rat liver and kidney ultrafiltrates. Carcinogenesis 12(9):1733\u20131737. https:\/\/doi.org\/10.1093\/carcin\/12.9.1733","journal-title":"Carcinogenesis"},{"issue":"4","key":"3285_CR308","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.bbrc.2009.07.090","volume":"387","author":"A Steinhoff","year":"2009","unstructured":"Steinhoff A, Pientka FK, Mockel S et al (2009) Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2. Biochem Biophys Res Commun 387(4):705\u2013711. https:\/\/doi.org\/10.1016\/j.bbrc.2009.07.090","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3285_CR309","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0891-5849(94)00159-H","volume":"18","author":"SJ Stohs","year":"1995","unstructured":"Stohs SJ, Bagchi D (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18(2):321\u2013336","journal-title":"Free Radic Biol Med"},{"issue":"41","key":"3285_CR310","doi-asserted-by":"publisher","first-page":"42719","DOI":"10.1074\/jbc.M406713200","volume":"279","author":"IP Stolze","year":"2004","unstructured":"Stolze IP, Tian YM, Appelhoff RJ et al (2004) Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. J Biol Chem 279(41):42719\u201342725. https:\/\/doi.org\/10.1074\/jbc.M406713200","journal-title":"J Biol Chem"},{"key":"3285_CR311","unstructured":"Sukosd F, Kuroda N, Beothe T, Kaur AP, Kovacs G (2003) Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res 63(2):455\u20137"},{"key":"3285_CR312","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1749-6632.1987.tb48762.x","volume":"514","author":"FW Sunderman Jr","year":"1987","unstructured":"Sunderman FW Jr (1987) Metal induction of heme oxygenase. Ann N Y Acad Sci 514:65\u201380. https:\/\/doi.org\/10.1111\/j.1749-6632.1987.tb48762.x","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"3285_CR313","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"3285_CR314","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.kint.2018.06.028","volume":"94","author":"N Suzuki","year":"2018","unstructured":"Suzuki N, Matsuo-Tezuka Y, Sasaki Y et al (2018) Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2alpha concentrations in renal interstitial fibroblasts. Kidney Int 94(5):900\u2013911. https:\/\/doi.org\/10.1016\/j.kint.2018.06.028","journal-title":"Kidney Int"},{"issue":"7","key":"3285_CR315","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.107.701516","volume":"116","author":"K Takeda","year":"2007","unstructured":"Takeda K, Cowan A, Fong GH (2007) Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116(7):774\u2013781. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.701516","journal-title":"Circulation"},{"issue":"6","key":"3285_CR316","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1182\/blood-2007-09-114561","volume":"111","author":"K Takeda","year":"2008","unstructured":"Takeda K, Aguila HL, Parikh NS et al (2008) Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 111(6):3229\u20133235. https:\/\/doi.org\/10.1182\/blood-2007-09-114561","journal-title":"Blood"},{"issue":"6","key":"3285_CR317","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s10157-016-1241-4","volume":"20","author":"T Tanaka","year":"2016","unstructured":"Tanaka T (2016) Expanding roles of the hypoxia-response network in chronic kidney disease. Clin Exp Nephrol 20(6):835\u2013844. https:\/\/doi.org\/10.1007\/s10157-016-1241-4","journal-title":"Clin Exp Nephrol"},{"issue":"5","key":"3285_CR318","doi-asserted-by":"publisher","first-page":"F1123","DOI":"10.1152\/ajprenal.00081.2005","volume":"289","author":"T Tanaka","year":"2005","unstructured":"Tanaka T, Kojima I, Ohse T et al (2005a) Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity. Am J Physiol Renal Physiol 289(5):F1123\u2013F1133. https:\/\/doi.org\/10.1152\/ajprenal.00081.2005","journal-title":"Am J Physiol Renal Physiol"},{"issue":"10","key":"3285_CR319","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/labinvest.3700328","volume":"85","author":"T Tanaka","year":"2005","unstructured":"Tanaka T, Kojima I, Ohse T et al (2005b) Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model. Lab Invest 85(10):1292\u20131307. https:\/\/doi.org\/10.1038\/labinvest.3700328","journal-title":"Lab Invest"},{"issue":"6","key":"3285_CR320","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1111\/j.1523-1755.2005.00742.x","volume":"68","author":"T Tanaka","year":"2005","unstructured":"Tanaka T, Matsumoto M, Inagi R et al (2005c) Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis. Kidney Int 68(6):2714\u20132725. https:\/\/doi.org\/10.1111\/j.1523-1755.2005.00742.x","journal-title":"Kidney Int"},{"issue":"10","key":"3285_CR321","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1172\/JCI84433","volume":"126","author":"CT Taylor","year":"2016","unstructured":"Taylor CT, Doherty G, Fallon PG, Cummins EP (2016) Hypoxia-dependent regulation of inflammatory pathways in immune cells. J Clin Invest 126(10):3716\u20133724. https:\/\/doi.org\/10.1172\/JCI84433","journal-title":"J Clin Invest"},{"issue":"5","key":"3285_CR322","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1016\/j.ajpath.2011.07.012","volume":"179","author":"F Theilig","year":"2011","unstructured":"Theilig F, Enke AK, Scolari B, Polzin D, Bachmann S, Koesters R (2011) Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. Am J Pathol 179(5):2177\u20132188. https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.012","journal-title":"Am J Pathol"},{"key":"3285_CR323","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000070241","volume":"93","author":"F Th\u00e9venod","year":"2003","unstructured":"Th\u00e9venod F (2003) Nephrotoxicity and the proximal tubule. Insights from Cadmium Nephron Physiol 93:87\u201393. https:\/\/doi.org\/10.1159\/000070241","journal-title":"Insights from Cadmium Nephron Physiol"},{"key":"3285_CR324","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.taap.2009.01.013","volume":"238","author":"F Th\u00e9venod","year":"2009","unstructured":"Th\u00e9venod F (2009) Cadmium and cellular signaling cascades: To be or not to be? Toxicol Appl Pharmacol 238:221\u2013239. https:\/\/doi.org\/10.1016\/j.taap.2009.01.013","journal-title":"Toxicol Appl Pharmacol"},{"key":"3285_CR325","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1515\/9783110470734-021","volume":"18","author":"F Th\u00e9venod","year":"2018","unstructured":"Th\u00e9venod F (2018) Iron and Its Role in Cancer Defense: A Double-Edged Sword. Met Ions Life Sci 18:437\u2013467. https:\/\/doi.org\/10.1515\/9783110470734-021","journal-title":"Met Ions Life Sci"},{"key":"3285_CR326","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/978-94-007-5179-8_14","volume":"11","author":"F Th\u00e9venod","year":"2013","unstructured":"Th\u00e9venod F, Lee WK (2013) Toxicology of cadmium and its damage to Mammalian organs. Met Ions Life Sci 11:415\u2013490. https:\/\/doi.org\/10.1007\/978-94-007-5179-8_14","journal-title":"Met Ions Life Sci"},{"key":"3285_CR327","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1039\/c5mt00215j","volume":"8","author":"F Th\u00e9venod","year":"2016","unstructured":"Th\u00e9venod F, Wolff NA (2016) Iron transport in the kidney: implications for physiology and cadmium nephrotoxicity. Metallomics Integr Biomet Sci 8:17\u201342. https:\/\/doi.org\/10.1039\/c5mt00215j","journal-title":"Metallomics Integr Biomet Sci"},{"key":"3285_CR328","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3389\/fcell.2020.00848","volume":"8","author":"F Th\u00e9venod","year":"2020","unstructured":"Th\u00e9venod F, Lee WK, Garrick MD (2020) Iron and Cadmium Entry Into Renal Mitochondria: Physiological and Toxicological Implications. Front Cell Dev Biol 8:848. https:\/\/doi.org\/10.3389\/fcell.2020.00848","journal-title":"Front Cell Dev Biol"},{"key":"3285_CR329","doi-asserted-by":"publisher","DOI":"10.1159\/000518632","author":"R Tiwari","year":"2021","unstructured":"Tiwari R, Kapitsinou PP (2021) Role of endothelial prolyl-4-hydroxylase domain protein\/hypoxia-inducible factor axis in acute kidney injury. Nephron. https:\/\/doi.org\/10.1159\/000518632","journal-title":"Nephron"},{"key":"3285_CR330","first-page":"375","volume":"8","author":"EJ Tokar","year":"2011","unstructured":"Tokar EJ, Benbrahim-Tallaa L, Waalkes MP (2011) Metal ions in human cancer development. Met Ions Life Sci 8:375\u2013401","journal-title":"Met Ions Life Sci"},{"key":"3285_CR331","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-nutr-082117-051732","volume":"38","author":"SV Torti","year":"2018","unstructured":"Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM (2018) Iron and Cancer. Annu Rev Nutr 38:97\u2013125. https:\/\/doi.org\/10.1146\/annurev-nutr-082117-051732","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"3285_CR332","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1349-7006.2008.01001.x","volume":"100","author":"S Toyokuni","year":"2009","unstructured":"Toyokuni S (2009) Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci 100(1):9\u201316. https:\/\/doi.org\/10.1111\/j.1349-7006.2008.01001.x","journal-title":"Cancer Sci"},{"issue":"2","key":"3285_CR333","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1681\/ASN.2006080894","volume":"18","author":"MJ Tracz","year":"2007","unstructured":"Tracz MJ, Alam J, Nath KA (2007) Physiology and pathophysiology of heme: implications for kidney disease. J Am Soc Nephrol 18(2):414\u2013420. https:\/\/doi.org\/10.1681\/ASN.2006080894","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"3285_CR334","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.kint.2017.03.013","volume":"92","author":"TL Tsai","year":"2017","unstructured":"Tsai TL, Kuo CC, Pan WH et al (2017) The decline in kidney function with chromium exposure is exacerbated with co-exposure to lead and cadmium. Kidney Int 92(3):710\u2013720. https:\/\/doi.org\/10.1016\/j.kint.2017.03.013","journal-title":"Kidney Int"},{"key":"3285_CR335","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.jinorgbio.2016.07.015","volume":"163","author":"O Tsave","year":"2016","unstructured":"Tsave O, Yavropoulou MP, Kafantari M, Gabriel C, Yovos JG, Salifoglou A (2016) The adipogenic potential of Cr(III). A molecular approach exemplifying metal-induced enhancement of insulin mimesis in diabetes mellitus II. J Inorg Biochem 163:323\u2013331. https:\/\/doi.org\/10.1016\/j.jinorgbio.2016.07.015","journal-title":"J Inorg Biochem"},{"key":"3285_CR336","first-page":"1107","volume-title":"Casarett and Doull's toxicology : the basic science of poisons","author":"AC Ufelle","year":"2019","unstructured":"Ufelle AC, Barchowsky A (2019) Toxic effects of metals. In: Klaassen CD (ed) Casarett and Doull\u2019s toxicology\u202f: the basic science of poisons, 9th edn. McGraw-Hill, New York, pp 1107\u20131162","edition":"9"},{"issue":"3","key":"3285_CR337","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1016\/j.bbrc.2018.07.099","volume":"503","author":"Y Urakami-Takebayashi","year":"2018","unstructured":"Urakami-Takebayashi Y, Kuroda Y, Murata T, Miyazaki M, Nagai J (2018) Pioglitazone induces hypoxia-inducible factor 1 activation in human renal proximal tubular epithelial cell line HK-2. Biochem Biophys Res Commun 503(3):1682\u20131688. https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.099","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"3285_CR338","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.2174\/0929867053764635","volume":"12","author":"M Valko","year":"2005","unstructured":"Valko M, Morris H, Cronin MT (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12(10):1161\u20131208","journal-title":"Curr Med Chem"},{"issue":"11","key":"3285_CR339","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41581-019-0181-0","volume":"15","author":"K Van Avondt","year":"2019","unstructured":"Van Avondt K, Nur E, Zeerleder S (2019) Mechanisms of haemolysis-induced kidney injury. Nat Rev Nephrol 15(11):671\u2013692. https:\/\/doi.org\/10.1038\/s41581-019-0181-0","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"3285_CR340","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/(sici)1098-2264(199708)19:4<220::aid-gcc3>3.0.co;2-z","volume":"19","author":"A van den Berg","year":"1997","unstructured":"van den Berg A, Draaijers TG, Kok K et al (1997) Normal FHIT transcripts in renal cell cancer- and lung cancer-derived cell lines, including a cell line with a homozygous deletion in the FRA3B region. Genes Chromosomes Cancer 19(4):220\u2013227. https:\/\/doi.org\/10.1002\/(sici)1098-2264(199708)19:4%3c220::aid-gcc3%3e3.0.co;2-z","journal-title":"Genes Chromosomes Cancer"},{"issue":"1","key":"3285_CR341","doi-asserted-by":"publisher","first-page":"9353","DOI":"10.1038\/s41598-018-27107-8","volume":"8","author":"S van Raaij","year":"2018","unstructured":"van Raaij S, van Swelm R, Bouman K et al (2018) Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease. Sci Rep 8(1):9353. https:\/\/doi.org\/10.1038\/s41598-018-27107-8","journal-title":"Sci Rep"},{"issue":"9","key":"3285_CR342","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1681\/ASN.2015040461","volume":"27","author":"RP van Swelm","year":"2016","unstructured":"van Swelm RP, Wetzels JF, Verweij VG et al (2016) Renal handling of circulating and renal-synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injury. J Am Soc Nephrol 27(9):2720\u20132732. https:\/\/doi.org\/10.1681\/ASN.2015040461","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3285_CR343","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41419-018-0568-z","volume":"9","author":"RPL van Swelm","year":"2018","unstructured":"van Swelm RPL, Vos M, Verhoeven F, Th\u00e9venod F, Swinkels DW (2018) Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis. Cell Death Dis 9(5):550. https:\/\/doi.org\/10.1038\/s41419-018-0568-z","journal-title":"Cell Death Dis"},{"issue":"2","key":"3285_CR344","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41581-019-0197-5","volume":"16","author":"RPL van Swelm","year":"2020","unstructured":"van Swelm RPL, Wetzels JFM, Swinkels DW (2020) The multifaceted role of iron in renal health and disease. Nat Rev Nephrol 16(2):77\u201398. https:\/\/doi.org\/10.1038\/s41581-019-0197-5","journal-title":"Nat Rev Nephrol"},{"key":"3285_CR345","doi-asserted-by":"publisher","first-page":"9912436","DOI":"10.1155\/2021\/9912436","volume":"2021","author":"GE Villalpando-Rodriguez","year":"2021","unstructured":"Villalpando-Rodriguez GE, Gibson SB (2021) Reactive oxygen species (ROS) regulates different types of cell death by acting as a rheostat. Oxid Med Cell Longev 2021:9912436. https:\/\/doi.org\/10.1155\/2021\/9912436","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"3285_CR346","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1042\/BJ20071052","volume":"408","author":"D Villar","year":"2007","unstructured":"Villar D, Vara-Vega A, Landazuri MO, Del Peso L (2007) Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains. Biochem J 408(2):231\u2013240. https:\/\/doi.org\/10.1042\/BJ20071052","journal-title":"Biochem J"},{"issue":"1","key":"3285_CR347","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12929-019-0518-9","volume":"26","author":"V Volarevic","year":"2019","unstructured":"Volarevic V, Djokovic B, Jankovic MG et al (2019) Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci 26(1):25. https:\/\/doi.org\/10.1186\/s12929-019-0518-9","journal-title":"J Biomed Sci"},{"issue":"10","key":"3285_CR348","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1177\/096032719401301007","volume":"13","author":"A Vyskocil","year":"1994","unstructured":"Vyskocil A, Viau C, Cizkova M (1994) Chronic nephrotoxicity of soluble nickel in rats. Hum Exp Toxicol 13(10):689\u2013693. https:\/\/doi.org\/10.1177\/096032719401301007","journal-title":"Hum Exp Toxicol"},{"issue":"3","key":"3285_CR349","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1074\/jbc.270.3.1230","volume":"270","author":"GL Wang","year":"1995","unstructured":"Wang GL, Semenza GL (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270(3):1230\u20131237. https:\/\/doi.org\/10.1074\/jbc.270.3.1230","journal-title":"J Biol Chem"},{"issue":"12","key":"3285_CR350","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","volume":"92","author":"GL Wang","year":"1995","unstructured":"Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92(12):5510\u20135514. https:\/\/doi.org\/10.1073\/pnas.92.12.5510","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"3285_CR351","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.freeradbiomed.2004.03.010","volume":"36","author":"Y Wang","year":"2004","unstructured":"Wang Y, Fang J, Leonard SS, Rao KM (2004) Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 36(11):1434\u20131443. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.03.010","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"3285_CR352","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1681\/ASN.2005121371","volume":"17","author":"J Wang","year":"2006","unstructured":"Wang J, Biju MP, Wang MH, Haase VH, Dong Z (2006) Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol 17(7):1875\u20131885. https:\/\/doi.org\/10.1681\/ASN.2005121371","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"3285_CR353","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00420-010-0569-4","volume":"84","author":"T Wang","year":"2011","unstructured":"Wang T, Jia G, Zhang J et al (2011) Renal impairment caused by chronic occupational chromate exposure. Int Arch Occup Environ Health 84(4):393\u2013401. https:\/\/doi.org\/10.1007\/s00420-010-0569-4","journal-title":"Int Arch Occup Environ Health"},{"issue":"2","key":"3285_CR354","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.taap.2011.12.022","volume":"259","author":"YF Wang","year":"2012","unstructured":"Wang YF, Shyu HW, Chang YC et al (2012a) Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway. Toxicol Appl Pharmacol 259(2):177\u2013186. https:\/\/doi.org\/10.1016\/j.taap.2011.12.022","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"3285_CR355","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/ndt\/gfr379","volume":"27","author":"Z Wang","year":"2012","unstructured":"Wang Z, Schley G, Turkoglu G et al (2012b) The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment. Nephrol Dial Transplant 27(3):929\u2013936. https:\/\/doi.org\/10.1093\/ndt\/gfr379","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"3285_CR356","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10529-013-1389-x","volume":"36","author":"W Wang","year":"2014","unstructured":"Wang W, Wang W, Jiang Y et al (2014) Human adipose-derived stem cells modified by HIF-1alpha accelerate the recovery of cisplatin-induced acute renal injury in vitro. Biotechnol Lett 36(3):667\u2013676. https:\/\/doi.org\/10.1007\/s10529-013-1389-x","journal-title":"Biotechnol Lett"},{"key":"3285_CR357","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1038\/srep10851","volume":"5","author":"WW Wang","year":"2015","unstructured":"Wang WW, Li ZZ, Wang W et al (2015) Enhanced renoprotective effect of HIF-1alpha modified human adipose-derived stem cells on cisplatin-induced acute kidney injury in vivo. Sci Rep 5:10851. https:\/\/doi.org\/10.1038\/srep10851","journal-title":"Sci Rep"},{"issue":"5","key":"3285_CR358","doi-asserted-by":"publisher","first-page":"523","DOI":"10.2307\/3579270","volume":"145","author":"P Wardman","year":"1996","unstructured":"Wardman P, Candeias LP (1996) Fenton chemistry: an introduction. Radiat Res 145(5):523\u2013531","journal-title":"Radiat Res"},{"issue":"12","key":"3285_CR359","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1096\/fj.04-1640fje","volume":"18","author":"C Warnecke","year":"2004","unstructured":"Warnecke C, Zaborowska Z, Kurreck J et al (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 18(12):1462\u20131464. https:\/\/doi.org\/10.1096\/fj.04-1640fje","journal-title":"FASEB J"},{"issue":"4","key":"3285_CR360","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4161\/epi.5.4.11684","volume":"5","author":"JA Watson","year":"2010","unstructured":"Watson JA, Watson CJ, McCann A, Baugh J (2010) Epigenetics, the epicenter of the hypoxic response. Epigenetics 5(4):293\u2013296. https:\/\/doi.org\/10.4161\/epi.5.4.11684","journal-title":"Epigenetics"},{"issue":"4\u20136","key":"3285_CR361","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1080\/15287398309530382","volume":"11","author":"H Weber","year":"1983","unstructured":"Weber H (1983) Long-term study of the distribution of soluble chromate-51 in the rat after a single intratracheal administration. J Toxicol Environ Health 11(4\u20136):749\u2013764. https:\/\/doi.org\/10.1080\/15287398309530382","journal-title":"J Toxicol Environ Health"},{"key":"3285_CR362","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1289\/ehp.92-1519395","volume":"92","author":"RP Wedeen","year":"1991","unstructured":"Wedeen RP, Qian LF (1991) Chromium-induced kidney disease. Environ Health Perspect 92:71\u201374. https:\/\/doi.org\/10.1289\/ehp.92-1519395","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3285_CR363","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1681\/ASN.2007040419","volume":"19","author":"A Weidemann","year":"2008","unstructured":"Weidemann A, Bernhardt WM, Klanke B et al (2008) HIF activation protects from acute kidney injury. J Am Soc Nephrol 19(3):486\u2013494. https:\/\/doi.org\/10.1681\/ASN.2007040419","journal-title":"J Am Soc Nephrol"},{"key":"3285_CR364","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.freeradbiomed.2021.03.018","volume":"170","author":"C Weinhouse","year":"2021","unstructured":"Weinhouse C (2021) The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants. Free Radic Biol Med 170:85\u2013108. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.03.018","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"3285_CR365","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.bbrc.2008.05.150","volume":"372","author":"S Wellmann","year":"2008","unstructured":"Wellmann S, Bettkober M, Zelmer A et al (2008) Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun 372(4):892\u2013897. https:\/\/doi.org\/10.1016\/j.bbrc.2008.05.150","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"3285_CR366","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1096\/fj.01-0944rev","volume":"16","author":"RH Wenger","year":"2002","unstructured":"Wenger RH (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16(10):1151\u20131162. https:\/\/doi.org\/10.1096\/fj.01-0944rev","journal-title":"FASEB J"},{"issue":"306","key":"3285_CR367","doi-asserted-by":"publisher","first-page":"re12","DOI":"10.1126\/stke.3062005re12","volume":"2005","author":"RH Wenger","year":"2005","unstructured":"Wenger RH, Stiehl DP (2005) Camenisch G (2005) Integration of oxygen signaling at the consensus HRE. Science\u2019s STKE: Signal Transduct Knowl Environ 2005(306):re12. https:\/\/doi.org\/10.1126\/stke.3062005re12","journal-title":"Science\u2019s STKE: Signal Transduct Knowl Environ"},{"key":"3285_CR368","unstructured":"WHO (1992) Cadmium. World Health Organization"},{"key":"3285_CR369","unstructured":"WHO (2010) Exposure to cadmium: a major public health concern International Programme on Chemical Safety. World Health Organization. https:\/\/www.who.int\/ipcs\/assessment\/public_health\/cadmium\/en\/"},{"issue":"7","key":"3285_CR370","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1182\/blood.V92.7.2260","volume":"92","author":"MS Wiesener","year":"1998","unstructured":"Wiesener MS, Turley H, Allen WE et al (1998) Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 92(7):2260\u20132268","journal-title":"Blood"},{"issue":"4","key":"3285_CR371","doi-asserted-by":"publisher","first-page":"e0175430","DOI":"10.1371\/journal.pone.0175430","volume":"12","author":"M Williams","year":"2017","unstructured":"Williams M, Bozhilov K, Ghai S, Talbot P (2017) Elements including metals in the atomizer and aerosol of disposable electronic cigarettes and electronic hookahs. PLoS ONE 12(4):e0175430. https:\/\/doi.org\/10.1371\/journal.pone.0175430","journal-title":"PLoS ONE"},{"issue":"11","key":"3285_CR372","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1073\/pnas.0810067106","volume":"106","author":"X Xia","year":"2009","unstructured":"Xia X, Lemieux ME, Li W et al (2009) Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci USA 106(11):4260\u20134265. https:\/\/doi.org\/10.1073\/pnas.0810067106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"3285_CR373","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3892\/ijmm.2012.1031","volume":"30","author":"F Xiao","year":"2012","unstructured":"Xiao F, Li Y, Dai L et al (2012) Hexavalent chromium targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent caspase-3 activation in L-02 hepatocytes. Int J Mol Med 30(3):629\u2013635. https:\/\/doi.org\/10.3892\/ijmm.2012.1031","journal-title":"Int J Mol Med"},{"issue":"6","key":"3285_CR374","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.4103\/jfmpc.jfmpc_78_20","volume":"9","author":"G Yadav","year":"2020","unstructured":"Yadav G, Chambial S, Agrawal N et al (2020) Blood lead levels in antenatal women and its association with iron deficiency anemia and adverse pregnancy outcomes. J Fam Med Prim Care 9(6):3106\u20133111. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_78_20","journal-title":"J Fam Med Prim Care"},{"issue":"2","key":"3285_CR375","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/s0888-7543(05)80234-4","volume":"14","author":"K Yamakawa","year":"1992","unstructured":"Yamakawa K, Takahashi E, Murata M, Okui K, Yokoyama S, Nakamura Y (1992) Detailed mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B. Genomics 14(2):412\u2013416. https:\/\/doi.org\/10.1016\/s0888-7543(05)80234-4","journal-title":"Genomics"},{"key":"3285_CR376","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1038\/ncomms2950","volume":"4","author":"S Yamazaki","year":"2013","unstructured":"Yamazaki S, Souma T, Hirano I et al (2013) A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nat Commun 4:1950. https:\/\/doi.org\/10.1038\/ncomms2950","journal-title":"Nat Commun"},{"issue":"5","key":"3285_CR377","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.bbamcr.2009.01.014","volume":"1793","author":"K Yasumoto","year":"2009","unstructured":"Yasumoto K, Kowata Y, Yoshida A, Torii S, Sogawa K (2009) Role of the intracellular localization of HIF-prolyl hydroxylases. Biochim Biophys Acta 1793(5):792\u2013797. https:\/\/doi.org\/10.1016\/j.bbamcr.2009.01.014","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"3285_CR378","doi-asserted-by":"publisher","first-page":"7651","DOI":"10.1039\/c7sc02103h","volume":"8","author":"TL Yeh","year":"2017","unstructured":"Yeh TL, Leissing TM, Abboud MI et al (2017) Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci 8(11):7651\u20137668. https:\/\/doi.org\/10.1039\/c7sc02103h","journal-title":"Chem Sci"},{"issue":"5","key":"3285_CR379","first-page":"1895","volume":"11","author":"JF Ying","year":"2021","unstructured":"Ying JF, Lu ZB, Fu LQ et al (2021) The role of iron homeostasis and iron-mediated ROS in cancer. Am J Cancer Res 11(5):1895\u20131912","journal-title":"Am J Cancer Res"},{"issue":"8","key":"3285_CR380","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1093\/ndt\/gfr754","volume":"27","author":"X Yu","year":"2012","unstructured":"Yu X, Fang Y, Liu H et al (2012) The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration. Nephrol Dial Transplant 27(8):3110\u20133119. https:\/\/doi.org\/10.1093\/ndt\/gfr754","journal-title":"Nephrol Dial Transplant"},{"key":"3285_CR381","volume-title":"Brenner & Rector's the kidney","author":"ASL Yu","year":"2019","unstructured":"Yu ASL, Chertow GM, Luyckx V, Marsden PA, Skorecki K, Taal MW (2019) Brenner & Rector\u2019s the kidney, 11th edn. Elsevier, Amsterdam","edition":"11"},{"issue":"4","key":"3285_CR382","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1006\/bbrc.2001.5835","volume":"288","author":"Y Yuan","year":"2001","unstructured":"Yuan Y, Beitner-Johnson D, Millhorn DE (2001) Hypoxia-inducible factor 2alpha binds to cobalt in vitro. Biochem Biophys Res Commun 288(4):849\u2013854. https:\/\/doi.org\/10.1006\/bbrc.2001.5835","journal-title":"Biochem Biophys Res Commun"},{"issue":"45","key":"3285_CR383","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1038\/sj.onc.1205835","volume":"21","author":"ER Zabarovsky","year":"2002","unstructured":"Zabarovsky ER, Lerman MI, Minna JD (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21(45):6915\u20136935. https:\/\/doi.org\/10.1038\/sj.onc.1205835","journal-title":"Oncogene"},{"issue":"2","key":"3285_CR384","first-page":"167","volume":"29","author":"D Zafirov","year":"2008","unstructured":"Zafirov D, Petrusevska G, Sikole A et al (2008) Erythropoietin reduces cumulative nephrotoxicity from cisplatin and enhances renal tubular cell proliferation. Prilozi 29(2):167\u2013183","journal-title":"Prilozi"},{"issue":"3 Pt 2","key":"3285_CR385","doi-asserted-by":"publisher","first-page":"F446","DOI":"10.1152\/ajprenal.1989.256.3.F446","volume":"256","author":"RA Zager","year":"1989","unstructured":"Zager RA, Gamelin LM (1989) Pathogenetic mechanisms in experimental hemoglobinuric acute renal failure. Am J Physiol 256(3 Pt 2):F446\u2013F455. https:\/\/doi.org\/10.1152\/ajprenal.1989.256.3.F446","journal-title":"Am J Physiol"},{"issue":"2","key":"3285_CR386","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1172\/JCI116251","volume":"91","author":"RA Zager","year":"1993","unstructured":"Zager RA, Schimpf BA, Bredl CR, Gmur DJ (1993) Inorganic iron effects on in vitro hypoxic proximal renal tubular cell injury. J Clin Invest 91(2):702\u2013708. https:\/\/doi.org\/10.1172\/JCI116251","journal-title":"J Clin Invest"},{"issue":"1","key":"3285_CR387","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.kint.2016.01.022","volume":"90","author":"RA Zager","year":"2016","unstructured":"Zager RA, Johnson AC, Frostad KB (2016) Combined iron sucrose and protoporphyrin treatment protects against ischemic and toxin-mediated acute renal failure. Kidney Int 90(1):67\u201376. https:\/\/doi.org\/10.1016\/j.kint.2016.01.022","journal-title":"Kidney Int"},{"issue":"3","key":"3285_CR388","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/ndt\/gfaa348","volume":"36","author":"RA Zager","year":"2021","unstructured":"Zager RA, Johnson ACM, Therapeutics R (2021) Iron sucrose ('RBT-3\u2019) activates the hepatic and renal HAMP1 gene, evoking renal hepcidin loading and resistance to cisplatin nephrotoxicity. Nephrol Dial Transplant 36(3):465\u2013474. https:\/\/doi.org\/10.1093\/ndt\/gfaa348","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"3285_CR389","doi-asserted-by":"publisher","first-page":"F254","DOI":"10.1152\/ajprenal.00594.2010","volume":"300","author":"A Zarjou","year":"2011","unstructured":"Zarjou A, Kim J, Traylor AM et al (2011) Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. Am J Physiol Renal Physiol 300(1):F254\u2013F262. https:\/\/doi.org\/10.1152\/ajprenal.00594.2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6124","key":"3285_CR390","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/327721a0","volume":"327","author":"B Zbar","year":"1987","unstructured":"Zbar B, Brauch H, Talmadge C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327(6124):721\u2013724. https:\/\/doi.org\/10.1038\/327721a0","journal-title":"Nature"},{"issue":"17","key":"3285_CR391","doi-asserted-by":"publisher","first-page":"8847","DOI":"10.1158\/0008-5472.CAN-06-0769","volume":"66","author":"S Zhang","year":"2006","unstructured":"Zhang S, Lovejoy KS, Shima JE et al (2006) Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res 66(17):8847\u20138857. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-0769","journal-title":"Cancer Res"},{"issue":"6","key":"3285_CR392","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.celrep.2014.02.011","volume":"6","author":"P Zhang","year":"2014","unstructured":"Zhang P, Yao Q, Lu L, Li Y, Chen PJ, Duan C (2014) Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Cell Rep 6(6):1110\u20131121. https:\/\/doi.org\/10.1016\/j.celrep.2014.02.011","journal-title":"Cell Rep"},{"issue":"10","key":"3285_CR393","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1042\/CS20210061","volume":"135","author":"H Zhao","year":"2021","unstructured":"Zhao H, Han Y, Jiang N et al (2021) Effects of HIF-1alpha on renal fibrosis in cisplatin-induced chronic kidney disease. Clin Sci (lond) 135(10):1273\u20131288. https:\/\/doi.org\/10.1042\/CS20210061","journal-title":"Clin Sci (lond)"},{"issue":"1","key":"3285_CR394","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/tx049774+","volume":"18","author":"A Zhitkovich","year":"2005","unstructured":"Zhitkovich A (2005) Importance of chromium-DNA adducts in mutagenicity and toxicity of chromium(VI). Chem Res Toxicol 18(1):3\u201311. https:\/\/doi.org\/10.1021\/tx049774+","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"3285_CR395","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/toxsci\/kfm260","volume":"101","author":"Y Zhou","year":"2008","unstructured":"Zhou Y, Vaidya VS, Brown RP et al (2008) Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 101(1):159\u2013170. https:\/\/doi.org\/10.1093\/toxsci\/kfm260","journal-title":"Toxicol Sci"},{"issue":"11","key":"3285_CR396","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1016\/j.biocel.2009.06.007","volume":"41","author":"J Zhou","year":"2009","unstructured":"Zhou J, Zhang W, Liang B et al (2009) PPARgamma activation induces autophagy in breast cancer cells. Int J Biochem Cell Biol 41(11):2334\u20132342. https:\/\/doi.org\/10.1016\/j.biocel.2009.06.007","journal-title":"Int J Biochem Cell Biol"},{"key":"3285_CR397","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","volume":"195","author":"MA Zoroddu","year":"2019","unstructured":"Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM (2019) The essential metals for humans: a brief overview. J Inorg Biochem 195:120\u2013129. https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.03.013","journal-title":"J Inorg Biochem"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-022-03285-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03285-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T18:10:03Z","timestamp":1652292603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-022-03285-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":397,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["3285"],"URL":"https:\/\/doi.org\/10.1007\/s00204-022-03285-3","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,21]]},"assertion":[{"value":"25 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}