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This disease was previously found primarily in tropical and subtropical areas but nowadays, the dinoflagellates producers of ciguatoxins had spread to European coasts. One decade ago, the European Food Safety Authority has raised the need to complete the toxicological available data for the ciguatoxin group of compounds. Thus, in this work, the in vivo effects of ciguatoxin-related compounds have been investigated using internationally adopted guidelines for the testing of chemicals. Intraperitoneal acute toxicity was tested for maitotoxin 1 at doses between 200 and 3200\u00a0ng\/kg and the acute oral toxicity of Pacific Ciguatoxin CTX3C at 330 and 1050\u00a0ng\/kg and maitotoxin 1 at 800\u00a0ng\/kg were also evaluated showing not effects on mice survival after a 96\u00a0h observation period. Therefore, for the following experiments the oral subchronic doses were between 172 and 1760\u00a0ng\/kg for gambierone, 10 and 102\u00a0ng\/kg for Pacific Ciguatoxin CTX3C, 550 and 1760\u00a0ng\/kg for maitotoxin 3 and 800, 2560 and 5000\u00a0ng\/kg for maitotoxin 1. The results presented here raise the need to reevaluate the in vivo activity of these agents. Although the intraperitoneal lethal dose of maitotoxin 1 is assumed to be 50\u00a0ng\/kg, without chemical purity identifications and description of the bioassay procedures, in this work, an intraperitoneal lethal dose of 1107\u00a0ng\/kg was obtained. Therefore, the data presented here highlight the need to use a common procedure and certified reference material to clearly establish the levels of these environmental contaminants in food.<\/jats:p>","DOI":"10.1007\/s00204-022-03315-0","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T15:03:48Z","timestamp":1654268628000},"page":"2621-2638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In vivo subchronic effects of ciguatoxin-related compounds, reevaluation of their toxicity"],"prefix":"10.1007","volume":"96","author":[{"given":"Sandra","family":"Raposo-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Boente-Juncal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodriguez-Vieytes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Cami\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Costas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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