{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:06:37Z","timestamp":1777482397407,"version":"3.51.4"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073948"],"award-info":[{"award-number":["82073948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703626"],"award-info":[{"award-number":["81703626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Innovation and Entrepreneurship Training Program for Undergraduate","award":["202210316040Z"],"award-info":[{"award-number":["202210316040Z"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00204-022-03403-1","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T03:02:27Z","timestamp":1667530947000},"page":"561-580","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity"],"prefix":"10.1007","volume":"97","author":[{"given":"Weichao","family":"Kong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengzhi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-0102","authenticated-orcid":false,"given":"Xinzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"issue":"1","key":"3403_CR1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ajpath.2010.11.026","volume":"178","author":"K Allen","year":"2011","unstructured":"Allen K, Jaeschke H, Copple BL (2011) Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178(1):175\u2013186. https:\/\/doi.org\/10.1016\/j.ajpath.2010.11.026","journal-title":"Am J Pathol"},{"issue":"15","key":"3403_CR2","first-page":"4516","volume":"63","author":"T Azuma","year":"2003","unstructured":"Azuma T, Takahashi T, Kunisato A, Kitamura T, Hirai H (2003) Human CD4+ CD25+ regulatory T cells suppress NKT cell functions. Cancer Res 63(15):4516\u20134520","journal-title":"Cancer Res"},{"issue":"9","key":"3403_CR3","doi-asserted-by":"publisher","first-page":"5175","DOI":"10.1128\/IAI.72.9.5175-5180.2004","volume":"72","author":"R Blackstock","year":"2004","unstructured":"Blackstock R, Murphy JW (2004) Age-related resistance of C57BL\/6 mice to Cryptococcus neoformans is dependent on maturation of NKT cells. Infect Immun 72(9):5175\u20135180. https:\/\/doi.org\/10.1128\/IAI.72.9.5175-5180.2004","journal-title":"Infect Immun"},{"issue":"13","key":"3403_CR4","doi-asserted-by":"publisher","first-page":"9945","DOI":"10.1074\/jbc.M010303200","volume":"276","author":"A Bonacchi","year":"2001","unstructured":"Bonacchi A, Romagnani P, Romanelli RG et al (2001) Signal transduction by the chemokine receptor CXCR3: activation of Ras\/ERK, Src, and phosphatidylinositol 3-kinase\/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem 276(13):9945\u20139954. https:\/\/doi.org\/10.1074\/jbc.M010303200","journal-title":"J Biol Chem"},{"issue":"10201","key":"3403_CR5","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0140-6736(19)31270-X","volume":"394","author":"LC Chappell","year":"2019","unstructured":"Chappell LC, Bell JL, Smith A et al (2019) Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet 394(10201):849\u2013860. https:\/\/doi.org\/10.1016\/S0140-6736(19)31270-X","journal-title":"Lancet"},{"issue":"6","key":"3403_CR6","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1586\/1744666X.2016.1147956","volume":"12","author":"J Choi","year":"2016","unstructured":"Choi J, Selmi C, Leung PS, Kenny TP, Roskams T, Gershwin ME (2016) Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis. Expert Rev Clin Immunol 12(6):661\u2013672. https:\/\/doi.org\/10.1586\/1744666X.2016.1147956","journal-title":"Expert Rev Clin Immunol"},{"issue":"2","key":"3403_CR7","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jaut.2005.08.009","volume":"25","author":"YH Chuang","year":"2005","unstructured":"Chuang YH, Lian ZX, Cheng CM et al (2005) Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives. J Autoimmun 25(2):126\u2013132. https:\/\/doi.org\/10.1016\/j.jaut.2005.08.009","journal-title":"J Autoimmun"},{"issue":"2","key":"3403_CR8","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/hep.22052","volume":"47","author":"YH Chuang","year":"2008","unstructured":"Chuang YH, Lian ZX, Yang GX et al (2008) Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology 47(2):571\u2013580. https:\/\/doi.org\/10.1002\/hep.22052","journal-title":"Hepatology"},{"issue":"9","key":"3403_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41577-018-0034-2","volume":"18","author":"CM Crosby","year":"2018","unstructured":"Crosby CM, Kronenberg M (2018) Tissue-specific functions of invariant natural killer T cells. Nat Rev Immunol 18(9):559\u2013574. https:\/\/doi.org\/10.1038\/s41577-018-0034-2","journal-title":"Nat Rev Immunol"},{"issue":"5343","key":"3403_CR10","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1126\/science.278.5343.1623","volume":"278","author":"J Cui","year":"1997","unstructured":"Cui J, Shin T, Kawano T et al (1997) Requirement for valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278(5343):1623\u20131626. https:\/\/doi.org\/10.1126\/science.278.5343.1623","journal-title":"Science"},{"key":"3403_CR11","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3389\/fimmu.2017.01414","volume":"8","author":"K Cui","year":"2017","unstructured":"Cui K, Yan G, Zheng X et al (2017) Suppression of natural killer cell activity by regulatory NKT10 cells aggravates alcoholic hepatosteatosis. Front Immunol 8:1414. https:\/\/doi.org\/10.3389\/fimmu.2017.01414","journal-title":"Front Immunol"},{"key":"3403_CR12","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.3389\/fimmu.2018.01752","volume":"9","author":"L De Giorgi","year":"2018","unstructured":"De Giorgi L, Sorini C, Cosorich I, Ferrarese R, Canducci F, Falcone M (2018) Increased iNKT17 Cell frequency in the intestine of non-obese diabetic mice correlates with high bacterioidales and low clostridiales abundance. Front Immunol 9:1752. https:\/\/doi.org\/10.3389\/fimmu.2018.01752","journal-title":"Front Immunol"},{"issue":"5","key":"3403_CR13","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/hep4.1170","volume":"2","author":"KL de Graaf","year":"2018","unstructured":"de Graaf KL, Lapeyre G, Guilhot F et al (2018) NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid. Hepatol Commun 2(5):492\u2013503. https:\/\/doi.org\/10.1002\/hep4.1170","journal-title":"Hepatol Commun"},{"key":"3403_CR14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002725","author":"JM Doisne","year":"2011","unstructured":"Doisne JM, Soulard V, Becourt C et al (2011) Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol. https:\/\/doi.org\/10.4049\/jimmunol.1002725","journal-title":"J Immunol"},{"key":"3403_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.molimm.2020.12.015","volume":"132","author":"MA Exley","year":"2021","unstructured":"Exley MA, Dellabona P, Casorati G (2021) Exploiting CD1-restricted T cells for clinical benefit. Mol Immunol 132:126\u2013131. https:\/\/doi.org\/10.1016\/j.molimm.2020.12.015","journal-title":"Mol Immunol"},{"key":"3403_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejim.2017.06.020","volume":"47","author":"A Floreani","year":"2018","unstructured":"Floreani A, Mangini C (2018) Primary biliary cholangitis: Old and novel therapy. Eur J Intern Med 47:1\u20135. https:\/\/doi.org\/10.1016\/j.ejim.2017.06.020","journal-title":"Eur J Intern Med"},{"issue":"7785","key":"3403_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","volume":"576","author":"S Hang","year":"2019","unstructured":"Hang S, Paik D, Yao L et al (2019) Bile acid metabolites control TH17 and treg cell differentiation. Nature 576(7785):143\u2013148. https:\/\/doi.org\/10.1038\/s41586-019-1785-z","journal-title":"Nature"},{"issue":"4","key":"3403_CR18","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.cmet.2017.03.007","volume":"25","author":"H Hao","year":"2017","unstructured":"Hao H, Cao L, Jiang C et al (2017) Farnesoid X Receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab 25(4):856\u2013867","journal-title":"Cell Metab"},{"issue":"7344","key":"3403_CR19","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nature09978","volume":"472","author":"JR Huh","year":"2011","unstructured":"Huh JR, Leung MW, Huang P et al (2011) Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing rorgammat activity. Nature 472(7344):486\u2013490. https:\/\/doi.org\/10.1038\/nature09978","journal-title":"Nature"},{"key":"3403_CR20","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3389\/fimmu.2019.02633","volume":"10","author":"TJ Hydes","year":"2019","unstructured":"Hydes TJ, Blunt MD, Naftel J et al (2019) Constitutive activation of natural killer cells in primary biliary cholangitis. Front Immunol 10:2633. https:\/\/doi.org\/10.3389\/fimmu.2019.02633","journal-title":"Front Immunol"},{"key":"3403_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2A0622-586RRRR","author":"H Jia","year":"2022","unstructured":"Jia H, Chen J, Zhang X et al (2022) IL-17A produced by invariant natural killer T cells and CD3(+) CD56(+) alphaGalcer-CD1d tetramer(-) T cells promote liver fibrosis in patients with primary biliary cholangitis. J Leukoc Biol. https:\/\/doi.org\/10.1002\/JLB.2A0622-586RRRR","journal-title":"J Leukoc Biol"},{"key":"3403_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-230X-13-79","volume":"13","author":"F Jin","year":"2013","unstructured":"Jin F, Cheng D, Tao JY et al (2013) Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis. BMC Gastroenterol 13:79. https:\/\/doi.org\/10.1186\/1471-230X-13-79","journal-title":"BMC Gastroenterol"},{"issue":"6","key":"3403_CR23","doi-asserted-by":"publisher","first-page":"2960","DOI":"10.4049\/jimmunol.171.6.2960","volume":"171","author":"B Johnston","year":"2003","unstructured":"Johnston B, Kim CH, Soler D, Emoto M, Butcher EC (2003) Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. J Immunol 171(6):2960\u20132969. https:\/\/doi.org\/10.4049\/jimmunol.171.6.2960","journal-title":"J Immunol"},{"key":"3403_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2172-14-16","volume":"14","author":"KL Jordan-Williams","year":"2013","unstructured":"Jordan-Williams KL, Poston S, Taparowsky EJ (2013) BATF regulates the development and function of IL-17 producing iNKT cells. BMC Immunol 14:16. https:\/\/doi.org\/10.1186\/1471-2172-14-16","journal-title":"BMC Immunol"},{"key":"3403_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cyto.2018.02.012","volume":"109","author":"N Karin","year":"2018","unstructured":"Karin N, Razon H (2018) Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity. Cytokine 109:24\u201328. https:\/\/doi.org\/10.1016\/j.cyto.2018.02.012","journal-title":"Cytokine"},{"issue":"6","key":"3403_CR26","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/j.jaci.2007.02.036","volume":"119","author":"M Kawaguchi","year":"2007","unstructured":"Kawaguchi M, Kokubu F, Huang SK et al (2007) The IL-17F signaling pathway is involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells. J Allergy Clin Immunol 119(6):1408\u20131414. https:\/\/doi.org\/10.1016\/j.jaci.2007.02.036","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"3403_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ni1449","volume":"8","author":"SA Khader","year":"2007","unstructured":"Khader SA, Bell GK, Pearl JE et al (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during mycobacterium tuberculosis challenge. Nat Immunol 8(4):369\u2013377. https:\/\/doi.org\/10.1038\/ni1449","journal-title":"Nat Immunol"},{"issue":"1","key":"3403_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1182\/blood-2001-12-0196","volume":"100","author":"CH Kim","year":"2002","unstructured":"Kim CH, Johnston B, Butcher EC (2002) Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood 100(1):11\u201316. https:\/\/doi.org\/10.1182\/blood-2001-12-0196","journal-title":"Blood"},{"issue":"2","key":"3403_CR29","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/toxsci\/kfj111","volume":"90","author":"ND Kim","year":"2006","unstructured":"Kim ND, Moon JO, Slitt AL, Copple BL (2006) Early growth response factor-1 is critical for cholestatic liver injury. Toxicol Sci 90(2):586\u2013595. https:\/\/doi.org\/10.1093\/toxsci\/kfj111","journal-title":"Toxicol Sci"},{"issue":"6","key":"3403_CR30","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3109\/14767058.2015.1028354","volume":"29","author":"A Kirbas","year":"2016","unstructured":"Kirbas A, Biberoglu E, Ersoy AO et al (2016) The role of interleukin-17 in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 29(6):977\u2013981. https:\/\/doi.org\/10.3109\/14767058.2015.1028354","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"3403_CR31","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1093\/toxsci\/kfp165","volume":"111","author":"E Kobayashi","year":"2009","unstructured":"Kobayashi E, Kobayashi M, Tsuneyama K, Fukami T, Nakajima M, Yokoi T (2009) Halothane-induced liver injury is mediated by interleukin-17 in mice. Toxicol Sci 111(2):302\u2013310. https:\/\/doi.org\/10.1093\/toxsci\/kfp165","journal-title":"Toxicol Sci"},{"issue":"1\u20133","key":"3403_CR32","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tox.2010.05.011","volume":"275","author":"M Kobayashi","year":"2010","unstructured":"Kobayashi M, Higuchi S, Mizuno K et al (2010) Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice. Toxicology 275(1\u20133):50\u201357. https:\/\/doi.org\/10.1016\/j.tox.2010.05.011","journal-title":"Toxicology"},{"issue":"7","key":"3403_CR33","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1080\/14767058.2017.1300652","volume":"31","author":"X Kong","year":"2018","unstructured":"Kong X, Kong Y, Zhang F, Wang T, Zhu X (2018) Expression and significance of dendritic cells and Th17\/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 31(7):901\u2013906. https:\/\/doi.org\/10.1080\/14767058.2017.1300652","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5677","key":"3403_CR34","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1136\/bmj.4.5677.204","volume":"4","author":"M Kontturi","year":"1969","unstructured":"Kontturi M, Sotaniemi E (1969) Effect of oestrogen on liver function of prostatic cancer patients. Br Med J 4(5677):204\u2013205. https:\/\/doi.org\/10.1136\/bmj.4.5677.204","journal-title":"Br Med J"},{"issue":"3","key":"3403_CR35","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2015.06.025","volume":"43","author":"YJ Lee","year":"2015","unstructured":"Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA (2015) Tissue-specific distribution of iNKT cells impacts their cytokine response. Immunity 43(3):566\u2013578. https:\/\/doi.org\/10.1016\/j.immuni.2015.06.025","journal-title":"Immunity"},{"issue":"1","key":"3403_CR36","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00204-016-1697-8","volume":"91","author":"X Li","year":"2017","unstructured":"Li X, Liu R, Luo L et al (2017a) Role of AMP-activated protein kinase alpha1 in 17alpha-ethinylestradiol-induced cholestasis in rats. Arch Toxicol 91(1):481\u2013494. https:\/\/doi.org\/10.1007\/s00204-016-1697-8","journal-title":"Arch Toxicol"},{"issue":"Pt B","key":"3403_CR37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.phrs.2017.09.002","volume":"125","author":"X Li","year":"2017","unstructured":"Li X, Liu R, Zhang L, Jiang Z (2017b) The emerging role of AMP-activated protein kinase in cholestatic liver diseases. Pharmacol Res 125(Pt B):105\u2013113. https:\/\/doi.org\/10.1016\/j.phrs.2017.09.002","journal-title":"Pharmacol Res"},{"issue":"1","key":"3403_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/cei.12032","volume":"172","author":"P Manousou","year":"2013","unstructured":"Manousou P, Kolios G, Drygiannakis I et al (2013) CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin Exp Immunol 172(1):9\u201315. https:\/\/doi.org\/10.1111\/cei.12032","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"3403_CR39","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.immuni.2020.01.002","volume":"52","author":"AM McGinley","year":"2020","unstructured":"McGinley AM, Sutton CE, Edwards SC et al (2020) Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1beta-producing myeloid cells that promote pathogenic T cells. Immunity 52(2):342\u2013356","journal-title":"Immunity"},{"issue":"10","key":"3403_CR40","doi-asserted-by":"publisher","first-page":"6657","DOI":"10.4049\/jimmunol.0901347","volume":"183","author":"A Mencarelli","year":"2009","unstructured":"Mencarelli A, Renga B, Migliorati M et al (2009) The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 183(10):6657\u20136666. https:\/\/doi.org\/10.4049\/jimmunol.0901347","journal-title":"J Immunol"},{"issue":"2","key":"3403_CR41","doi-asserted-by":"publisher","first-page":"805","DOI":"10.4049\/jimmunol.1201010","volume":"190","author":"M Monteiro","year":"2013","unstructured":"Monteiro M, Almeida CF, Agua-Doce A, Graca L (2013) Induced IL-17-producing invariant NKT cells require activation in presence of TGF-beta and IL-1beta. J Immunol 190(2):805\u2013811. https:\/\/doi.org\/10.4049\/jimmunol.1201010","journal-title":"J Immunol"},{"issue":"2","key":"3403_CR42","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1046\/j.1365-2249.2001.01391.x","volume":"123","author":"K Nishioji","year":"2001","unstructured":"Nishioji K, Okanoue T, Itoh Y et al (2001) Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes. Clin Exp Immunol 123(2):271\u2013279. https:\/\/doi.org\/10.1046\/j.1365-2249.2001.01391.x","journal-title":"Clin Exp Immunol"},{"key":"3403_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109579","volume":"122","author":"C Nong","year":"2020","unstructured":"Nong C, Zou M, Xue R et al (2020) The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity. Biomed Pharmacother 122:109579. https:\/\/doi.org\/10.1016\/j.biopha.2019.109579","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"3403_CR44","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1016\/j.ajpath.2013.07.019","volume":"183","author":"KM O'Brien","year":"2013","unstructured":"O\u2019Brien KM, Allen KM, Rockwell CE, Towery K, Luyendyk JP, Copple BL (2013) IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis. Am J Pathol 183(5):1498\u20131507. https:\/\/doi.org\/10.1016\/j.ajpath.2013.07.019","journal-title":"Am J Pathol"},{"issue":"12","key":"3403_CR45","doi-asserted-by":"publisher","first-page":"6815","DOI":"10.4049\/jimmunol.1003916","volume":"186","author":"SJ Oh","year":"2011","unstructured":"Oh SJ, Chung DH (2011) Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response. J Immunol 186(12):6815\u20136821. https:\/\/doi.org\/10.4049\/jimmunol.1003916","journal-title":"J Immunol"},{"issue":"2","key":"3403_CR46","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cmet.2018.01.007","volume":"27","author":"X Ouyang","year":"2018","unstructured":"Ouyang X, Han SN, Zhang JY et al (2018) Digoxin suppresses pyruvate kinase M2-promoted HIF-1alpha transactivation in steatohepatitis. Cell Metab 27(2):339\u2013350","journal-title":"Cell Metab"},{"issue":"2","key":"3403_CR47","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1084\/jem.20071507","volume":"205","author":"M Pichavant","year":"2008","unstructured":"Pichavant M, Goya S, Meyer EH et al (2008) Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 205(2):385\u2013393. https:\/\/doi.org\/10.1084\/jem.20071507","journal-title":"J Exp Med"},{"key":"3403_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051361","author":"J Piechota","year":"2020","unstructured":"Piechota J, Jelski W (2020) Intrahepatic cholestasis in pregnancy: review of the literature. J Clin Med. https:\/\/doi.org\/10.3390\/jcm9051361","journal-title":"J Clin Med"},{"issue":"1","key":"3403_CR49","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.cyto.2013.07.005","volume":"64","author":"C Qian","year":"2013","unstructured":"Qian C, Jiang T, Zhang W et al (2013) Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis. Cytokine 64(1):172\u2013180. https:\/\/doi.org\/10.1016\/j.cyto.2013.07.005","journal-title":"Cytokine"},{"issue":"8","key":"3403_CR50","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.4049\/jimmunol.180.8.5167","volume":"180","author":"AV Rachitskaya","year":"2008","unstructured":"Rachitskaya AV, Hansen AM, Horai R et al (2008) Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180(8):5167\u20135171. https:\/\/doi.org\/10.4049\/jimmunol.180.8.5167","journal-title":"J Immunol"},{"issue":"12","key":"3403_CR51","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/CS20110184","volume":"121","author":"MG Roma","year":"2011","unstructured":"Roma MG, Toledo FD, Boaglio AC, Basiglio CL, Crocenzi FA, Sanchez Pozzi EJ (2011) Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. Clin Sci (lond) 121(12):523\u2013544. https:\/\/doi.org\/10.1042\/CS20110184","journal-title":"Clin Sci (lond)"},{"issue":"5","key":"3403_CR52","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.4049\/jimmunol.169.5.2685","volume":"169","author":"I Salomon","year":"2002","unstructured":"Salomon I, Netzer N, Wildbaum G, Schif-Zuck S, Maor G, Karin N (2002) Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis. J Immunol 169(5):2685\u20132693. https:\/\/doi.org\/10.4049\/jimmunol.169.5.2685","journal-title":"J Immunol"},{"issue":"7","key":"3403_CR53","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1084\/jem.191.7.1233","volume":"191","author":"R Schwandner","year":"2000","unstructured":"Schwandner R, Yamaguchi K, Cao Z (2000) Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med 191(7):1233\u20131240. https:\/\/doi.org\/10.1084\/jem.191.7.1233","journal-title":"J Exp Med"},{"issue":"3","key":"3403_CR54","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jsps.2022.01.007","volume":"30","author":"ME Shaker","year":"2022","unstructured":"Shaker ME, Hamed MF, Shaaban AA (2022) Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators. Saudi Pharm J 30(3):291\u2013299. https:\/\/doi.org\/10.1016\/j.jsps.2022.01.007","journal-title":"Saudi Pharm J"},{"issue":"2","key":"3403_CR55","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cyto.2012.05.002","volume":"59","author":"AM Sidahmed","year":"2012","unstructured":"Sidahmed AM, Leon AJ, Bosinger SE et al (2012) CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine 59(2):433\u2013441. https:\/\/doi.org\/10.1016\/j.cyto.2012.05.002","journal-title":"Cytokine"},{"key":"3403_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194694","author":"LE Soria-Jasso","year":"2019","unstructured":"Soria-Jasso LE, Carino-Cortes R, Munoz-Perez VM, Perez-Hernandez E, Perez-Hernandez N, Fernandez-Martinez E (2019) Beneficial and deleterious effects of female sex hormones, oral contraceptives, and phytoestrogens by immunomodulation on the liver. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20194694","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3403_CR57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.21037\/atm-20-2427","volume":"9","author":"K Sun","year":"2021","unstructured":"Sun K, Ma S, Tian S et al (2021) An enhanced level of LAMP-2A participates in CD4(+)T cell hyperactivity in patients with primary biliary cholangitis. Ann Transl Med 9(2):101. https:\/\/doi.org\/10.21037\/atm-20-2427","journal-title":"Ann Transl Med"},{"issue":"5","key":"3403_CR58","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.4049\/jimmunol.171.5.2571","volume":"171","author":"SY Thomas","year":"2003","unstructured":"Thomas SY, Hou R, Boyson JE et al (2003) CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol 171(5):2571\u20132580. https:\/\/doi.org\/10.4049\/jimmunol.171.5.2571","journal-title":"J Immunol"},{"issue":"1","key":"3403_CR59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nri1531","volume":"5","author":"L Van Kaer","year":"2005","unstructured":"Van Kaer L (2005) alpha-galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat Rev Immunol 5(1):31\u201342. https:\/\/doi.org\/10.1038\/nri1531","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"3403_CR60","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41467-018-07911-6","volume":"10","author":"K Venken","year":"2019","unstructured":"Venken K, Jacques P, Mortier C et al (2019) RORgammat inhibition selectively targets IL-17 producing iNKT and gammadelta-T cells enriched in Spondyloarthritis patients. Nat Commun 10(1):9. https:\/\/doi.org\/10.1038\/s41467-018-07911-6","journal-title":"Nat Commun"},{"issue":"3","key":"3403_CR61","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1182\/blood-2009-02-205492","volume":"114","author":"KL Wallace","year":"2009","unstructured":"Wallace KL, Marshall MA, Ramos SI et al (2009) NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Blood 114(3):667\u2013676. https:\/\/doi.org\/10.1182\/blood-2009-02-205492","journal-title":"Blood"},{"key":"3403_CR62","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.fct.2014.06.004","volume":"71","author":"X Wang","year":"2014","unstructured":"Wang X, Jiang Z, Xing M et al (2014) Interleukin-17 mediates triptolide-induced liver injury in mice. Food Chem Toxicol 71:33\u201341. https:\/\/doi.org\/10.1016\/j.fct.2014.06.004","journal-title":"Food Chem Toxicol"},{"issue":"7","key":"3403_CR63","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1039\/c9fo00318e","volume":"10","author":"J Wang","year":"2019","unstructured":"Wang J, Fu T, Dong R et al (2019) Hepatoprotection of auraptene from the peels of citrus fruits against 17alpha-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor. Food Funct 10(7):3839\u20133850. https:\/\/doi.org\/10.1039\/c9fo00318e","journal-title":"Food Funct"},{"key":"3403_CR64","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30606","author":"L Wang","year":"2021","unstructured":"Wang L, You HM, Meng HW et al (2021) STING-mediated inflammation contributes to Gao binge ethanol feeding model. J Cell Physiol. https:\/\/doi.org\/10.1002\/jcp.30606","journal-title":"J Cell Physiol"},{"issue":"11","key":"3403_CR65","doi-asserted-by":"publisher","first-page":"5885","DOI":"10.4049\/jimmunol.168.11.5885","volume":"168","author":"G Wildbaum","year":"2002","unstructured":"Wildbaum G, Netzer N, Karin N (2002) Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J Immunol 168(11):5885\u20135892. https:\/\/doi.org\/10.4049\/jimmunol.168.11.5885","journal-title":"J Immunol"},{"issue":"3","key":"3403_CR66","first-page":"369","volume":"22","author":"Y Yoshiga","year":"2008","unstructured":"Yoshiga Y, Goto D, Segawa S et al (2008) Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis. Int J Mol Med 22(3):369\u2013374","journal-title":"Int J Mol Med"},{"key":"3403_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2016.10.016","volume":"264","author":"L Yu","year":"2016","unstructured":"Yu L, Liu X, Li X et al (2016) Protective effects of SRT1720 via the HNF1alpha\/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett 264:1\u201311. https:\/\/doi.org\/10.1016\/j.toxlet.2016.10.016","journal-title":"Toxicol Lett"},{"issue":"2","key":"3403_CR68","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/sji.12395","volume":"83","author":"S Zhang","year":"2016","unstructured":"Zhang S, Huang D, Weng J et al (2016) Neutralization of interleukin-17 attenuates cholestatic liver fibrosis in mice. Scand J Immunol 83(2):102\u2013108. https:\/\/doi.org\/10.1111\/sji.12395","journal-title":"Scand J Immunol"},{"issue":"4","key":"3403_CR69","doi-asserted-by":"publisher","first-page":"G387","DOI":"10.1152\/ajpgi.00054.2019","volume":"317","author":"P Zhao","year":"2019","unstructured":"Zhao P, Han SN, Arumugam S et al (2019) Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation. Am J Physiol Gastrointest Liver Physiol 317(4):G387\u2013G397. https:\/\/doi.org\/10.1152\/ajpgi.00054.2019","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"3403_CR70","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/2045-3701-3-46","volume":"3","author":"L Zheng","year":"2013","unstructured":"Zheng L, Chu J, Shi Y et al (2013) Bone marrow-derived stem cells ameliorate hepatic fibrosis by down-regulating interleukin-17. Cell Biosci 3(1):46. https:\/\/doi.org\/10.1186\/2045-3701-3-46","journal-title":"Cell Biosci"},{"key":"3403_CR71","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.intimp.2019.04.021","volume":"72","author":"H Zhu","year":"2019","unstructured":"Zhu H, Zhang Q, Chen G (2019) CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease. Int Immunopharmacol 72:224\u2013234. https:\/\/doi.org\/10.1016\/j.intimp.2019.04.021","journal-title":"Int Immunopharmacol"},{"key":"3403_CR72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218011","author":"X Zhu","year":"2020","unstructured":"Zhu X, Zhu J (2020) CD4 T helper cell subsets and related human immunological disorders. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21218011","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3403_CR73","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1172\/JCI71951","volume":"124","author":"Y Zohar","year":"2014","unstructured":"Zohar Y, Wildbaum G, Novak R et al (2014) CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis. J Clin Invest 124(5):2009\u20132022. https:\/\/doi.org\/10.1172\/JCI71951","journal-title":"J Clin Invest"},{"key":"3403_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111777","volume":"146","author":"M Zou","year":"2020","unstructured":"Zou M, Nong C, Yu Z et al (2020) The role of invariant natural killer T cells and associated immunoregulatory factors in triptolide-induced cholestatic liver injury. Food Chem Toxicol 146:111777. https:\/\/doi.org\/10.1016\/j.fct.2020.111777","journal-title":"Food Chem Toxicol"},{"key":"3403_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107328","volume":"92","author":"M Zou","year":"2021","unstructured":"Zou M, Wang A, Wei J et al (2021) An insight into the mechanism and molecular basis of dysfunctional immune response involved in cholestasis. Int Immunopharmacol 92:107328. https:\/\/doi.org\/10.1016\/j.intimp.2020.107328","journal-title":"Int Immunopharmacol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03403-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-022-03403-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03403-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T15:08:01Z","timestamp":1674227281000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-022-03403-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["3403"],"URL":"https:\/\/doi.org\/10.1007\/s00204-022-03403-1","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"assertion":[{"value":"27 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}