{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:21:45Z","timestamp":1790634105241,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006021","name":"Direction G\u00e9n\u00e9rale de l\u2019Armement","doi-asserted-by":"publisher","award":["grant PDH-2-NBC-4-C-4209"],"award-info":[{"award-number":["grant PDH-2-NBC-4-C-4209"]}],"id":[{"id":"10.13039\/501100006021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006021","name":"Direction G\u00e9n\u00e9rale de l\u2019Armement","doi-asserted-by":"publisher","award":["PDH-2-NBC-4-C-4212"],"award-info":[{"award-number":["PDH-2-NBC-4-C-4212"]}],"id":[{"id":"10.13039\/501100006021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00204-022-03408-w","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T12:04:40Z","timestamp":1667477080000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method"],"prefix":"10.1007","volume":"97","author":[{"given":"F.","family":"F\u00e9my","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Meesemaecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Belverge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Courageux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nervo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Reymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Chantegreil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Madi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2429","authenticated-orcid":false,"given":"F.","family":"Nachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Taudon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jaffr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"3408_CR1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/1523-1747.ep12538909","volume":"58","author":"MJ Bartek","year":"1972","unstructured":"Bartek MJ, LaBudde JA, Maibach HI (1972) Skin permeability in vivo: comparison in rat, rabbit, pig and man. J Investig Dermatol 58:114\u2013123. https:\/\/doi.org\/10.1111\/1523-1747.ep12538909","journal-title":"J Investig Dermatol"},{"key":"3408_CR2","doi-asserted-by":"crossref","unstructured":"Benschop HP, De Jong LPA (2001) Toxicokinetics of nerve agents. Vojen Zdr LISTY 11","DOI":"10.1201\/9781420041576.ch2"},{"key":"3408_CR3","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1021\/acs.chemrestox.8b00294","volume":"31","author":"SM Bester","year":"2018","unstructured":"Bester SM, Guelta MA, Cheung J et al (2018) Structural insights of stereospecific inhibition of human acetylcholinesterase by VX and subsequent reactivation by HI-6. Chem Res Toxicol 31:1405\u20131417. https:\/\/doi.org\/10.1021\/acs.chemrestox.8b00294","journal-title":"Chem Res Toxicol"},{"key":"3408_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/0960327108090269","volume":"27","author":"S Bjarnason","year":"2008","unstructured":"Bjarnason S, Mikler J, Hill I et al (2008) Comparison of selected skin decontaminant products and regimens against VX in domestic swine. Hum Exp Toxicol 27:253\u2013261. https:\/\/doi.org\/10.1177\/0960327108090269","journal-title":"Hum Exp Toxicol"},{"key":"3408_CR5","first-page":"1","volume-title":"Chemical warfare toxicology","author":"R Black","year":"2016","unstructured":"Black R (2016) Chapter 1\u2014development, historical use and properties of chemical warfare agents. In: Worek F, Jenner J, Thiermann H (eds) Chemical warfare toxicology. Royal Society of Chemistry, pp 1\u201328"},{"key":"3408_CR7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1191\/0960327105ht537oa","volume":"24","author":"RP Chilcott","year":"2005","unstructured":"Chilcott RP, Dalton CH, Hill I et al (2005) In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig. Hum Exp Toxicol 24:347\u2013352. https:\/\/doi.org\/10.1191\/0960327105ht537oa","journal-title":"Hum Exp Toxicol"},{"key":"3408_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/1523-1747.ep12496487","volume":"68","author":"FN Craig","year":"1977","unstructured":"Craig FN, Cummings EG, Sim VM (1977) Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor, VX. J Investig Dermatol 68:357\u2013361. https:\/\/doi.org\/10.1111\/1523-1747.ep12496487","journal-title":"J Investig Dermatol"},{"key":"3408_CR6","first-page":"39","volume":"9","author":"LM da Fonseca Carvalho","year":"2021","unstructured":"da Fonseca Carvalho LM (2021) Novichok(s) a challenge to the chemical weapons convention. Port J Mil Sci 9:39\u201362","journal-title":"Port J Mil Sci"},{"key":"3408_CR9","first-page":"42","volume":"2017","author":"F Dorandeu","year":"2017","unstructured":"Dorandeu F, Nachon F (2017) Des contre-mesures m\u00e9dicales face \u00e0 la menace des neurotoxiques organophosphor\u00e9s. Biofutur 2017:42\u201345","journal-title":"Biofutur"},{"key":"3408_CR10","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tox.2006.09.013","volume":"233","author":"F Dorandeu","year":"2007","unstructured":"Dorandeu F, Mikler JR, Thiermann H et al (2007) Swine models in the design of more effective medical countermeasures against organophosphorus poisoning. Toxicology 233:128\u2013144. https:\/\/doi.org\/10.1016\/j.tox.2006.09.013","journal-title":"Toxicology"},{"key":"3408_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/jat.838","volume":"22","author":"EJS Duncan","year":"2002","unstructured":"Duncan EJS, Brown A, Lundy P et al (2002) Site-specific percutaneous absorption of methyl salicylate and VX in domestic swine. J Appl Toxicol JAT 22:141\u2013148. https:\/\/doi.org\/10.1002\/jat.838","journal-title":"J Appl Toxicol JAT"},{"key":"3408_CR12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0140-6736(07)61202-1","volume":"371","author":"M Eddleston","year":"2008","unstructured":"Eddleston M, Buckley NA, Eyer P, Dawson AH (2008) Management of acute organophosphorus pesticide poisoning. Lancet Lond Engl 371:597\u2013607. https:\/\/doi.org\/10.1016\/S0140-6736(07)61202-1","journal-title":"Lancet Lond Engl"},{"key":"3408_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres V, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88\u201395","journal-title":"Biochem Pharmacol"},{"key":"3408_CR14","doi-asserted-by":"publisher","first-page":"166","DOI":"10.4103\/0975-7406.68498","volume":"2","author":"K Ganesan","year":"2010","unstructured":"Ganesan K, Raza SK, Vijayaraghavan R (2010) Chemical warfare agents. J Pharm Bioallied Sci 2:166\u2013178. https:\/\/doi.org\/10.4103\/0975-7406.68498","journal-title":"J Pharm Bioallied Sci"},{"key":"3408_CR15","volume-title":"Handbook of toxicology of chemical warfare agents","author":"RC Gupta","year":"2015","unstructured":"Gupta RC (2015) Handbook of toxicology of chemical warfare agents, 2nd edn. Academic Press Elsevier, Amsterdam","edition":"2"},{"key":"3408_CR16","doi-asserted-by":"publisher","first-page":"856","DOI":"10.7205\/milmed.169.11.856","volume":"169","author":"MG Hamilton","year":"2004","unstructured":"Hamilton MG, Hill I, Conley J et al (2004) Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. Mil Med 169:856\u2013862. https:\/\/doi.org\/10.7205\/milmed.169.11.856","journal-title":"Mil Med"},{"key":"3408_CR17","first-page":"315","volume":"27","author":"L Harris","year":"1984","unstructured":"Harris L, Broomfield C, Adams N, Stitcher D (1984) Detoxification of soman and o-cyclopentyl-s-diethylaminoethyl methylphosphonothioate in vivo. Proc West Pharmacol Soc 27:315\u2013318","journal-title":"Proc West Pharmacol Soc"},{"key":"3408_CR18","unstructured":"Hoenig SL (2007) Compendium of chemical warfare agents. https:\/\/link.springer.com\/book\/10.1007\/978-0-387-69260-9"},{"key":"3408_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1600-0846.2006.00179.x","volume":"13","author":"U Jacobi","year":"2007","unstructured":"Jacobi U, Kaiser M, Toll R et al (2007) Porcine ear skin: an in vitro model for human skin. Skin Res Technol 13:19\u201324. https:\/\/doi.org\/10.1111\/j.1600-0846.2006.00179.x","journal-title":"Skin Res Technol"},{"key":"3408_CR20","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/B978-0-12-819090-6.00052-0","volume-title":"Handbook of toxicology of chemical warfare agents","author":"H John","year":"2020","unstructured":"John H, Balszuweit F, Steinritz D et al (2020) Chapter 52\u2014toxicokinetic aspects of nerve agents and vesicants. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents, 3rd edn. Academic Press, Boston, pp 875\u2013919","edition":"3"},{"key":"3408_CR21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1007\/s002040050393","volume":"71","author":"JP Langenberg","year":"1997","unstructured":"Langenberg JP, van Dijk C, Sweeney RE et al (1997) Development of a physiologically based model for the toxicokinetics of C(+\/\u2212)P(+\/\u2212)-soman in the atropinized guinea pig. Arch Toxicol 71:320\u2013331. https:\/\/doi.org\/10.1007\/s002040050393","journal-title":"Arch Toxicol"},{"key":"3408_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pharmthera.2014.11.011","volume":"148","author":"O Lockridge","year":"2015","unstructured":"Lockridge O (2015) Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses. Pharmacol Ther 148:34\u201346. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.011","journal-title":"Pharmacol Ther"},{"key":"3408_CR23","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.toxlet.2017.11.029","volume":"293","author":"TM Mann","year":"2018","unstructured":"Mann TM, Price ME, Whitmore CL et al (2018) Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig. Toxicol Lett 293:198\u2013206. https:\/\/doi.org\/10.1016\/j.toxlet.2017.11.029","journal-title":"Toxicol Lett"},{"key":"3408_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/9780470060032","volume-title":"Chemical warfare agents: toxicology and treatment","author":"TC Marrs","year":"2007","unstructured":"Marrs TC, Maynard RL, Sidell FR (2007) Chemical warfare agents: toxicology and treatment, 2nd edn. Wiley, New York","edition":"2"},{"key":"3408_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.toxlet.2011.05.1047","volume":"206","author":"J Mikler","year":"2011","unstructured":"Mikler J, Tenn C, Worek F et al (2011) Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures. Toxicol Lett 206:47\u201353. https:\/\/doi.org\/10.1016\/j.toxlet.2011.05.1047","journal-title":"Toxicol Lett"},{"key":"3408_CR26","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.cbi.2012.08.018","volume":"203","author":"H Mumford","year":"2013","unstructured":"Mumford H, Docx CJ, Price ME et al (2013) Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chem Biol Interact 203:160\u2013166. https:\/\/doi.org\/10.1016\/j.cbi.2012.08.018","journal-title":"Chem Biol Interact"},{"key":"3408_CR27","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1289\/ehp.99107933","volume":"107","author":"NB Munro","year":"1999","unstructured":"Munro NB, Talmage SS, Griffin GD et al (1999) The sources, fate, and toxicity of chemical warfare agent degradation products. Environ Health Perspect 107:933\u2013974. https:\/\/doi.org\/10.1289\/ehp.99107933","journal-title":"Environ Health Perspect"},{"key":"3408_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jchromb.2008.08.001","volume":"873","author":"G Reiter","year":"2008","unstructured":"Reiter G, Mikler J, Hill I et al (2008) Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples. J Chromatogr B Anal Technol Biomed Life Sci 873:86\u201394. https:\/\/doi.org\/10.1016\/j.jchromb.2008.08.001","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"3408_CR29","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1016\/j.jchromb.2011.07.031","volume":"879","author":"G Reiter","year":"2011","unstructured":"Reiter G, Mikler J, Hill I et al (2011) Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies. J Chromatogr B Anal Technol Biomed Life Sci 879:2704\u20132713. https:\/\/doi.org\/10.1016\/j.jchromb.2011.07.031","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"3408_CR30","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.toxlet.2014.11.010","volume":"232","author":"G Reiter","year":"2015","unstructured":"Reiter G, M\u00fcller S, Hill I et al (2015) In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects. Toxicol Lett 232:438\u2013448. https:\/\/doi.org\/10.1016\/j.toxlet.2014.11.010","journal-title":"Toxicol Lett"},{"key":"3408_CR31","unstructured":"Reutter SA, Mioduszewski RJ, Thomson SA (2000) Evaluation of airborne exposure limits for VX: worker and general population exposure criteria. ECBC-TR-074. https:\/\/www.federalregister.gov\/documents\/2002\/01\/08\/02-396\/airborne-exposure-limits-for-chemical-warfare-agents-ga-tabun-gb-sarin-and-vx"},{"key":"3408_CR32","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1016\/j.tiv.2011.06.021","volume":"25","author":"P Rolland","year":"2011","unstructured":"Rolland P, Bolzinger M-A, Cruz C et al (2011) Human scalp permeability to the chemical warfare agent VX. Toxicol Vitro Int J Publ Assoc BIBRA 25:1974\u20131980. https:\/\/doi.org\/10.1016\/j.tiv.2011.06.021","journal-title":"Toxicol Vitro Int J Publ Assoc BIBRA"},{"key":"3408_CR33","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.toxlet.2011.04.008","volume":"204","author":"TW Sawyer","year":"2011","unstructured":"Sawyer TW, Mikler J, Worek F et al (2011) The therapeutic use of localized cooling in the treatment of VX poisoning. Toxicol Lett 204:52\u201356. https:\/\/doi.org\/10.1016\/j.toxlet.2011.04.008","journal-title":"Toxicol Lett"},{"key":"3408_CR34","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1590\/S0100-40422012001000033","volume":"35","author":"GR Silva","year":"2012","unstructured":"Silva GR, Borges I Jr, Figueroa-Villar JD, de Castro AT (2012) Defesa qu\u00edmica: hist\u00f3rico, classifica\u00e7\u00e3o dos agentes de guerra e a\u00e7\u00e3o dos neurot\u00f3xicos. Qu\u00edm Nova 35:2083\u20132091. https:\/\/doi.org\/10.1590\/S0100-40422012001000033","journal-title":"Qu\u00edm Nova"},{"key":"3408_CR35","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(20)32644-1","volume":"397","author":"D Steindl","year":"2021","unstructured":"Steindl D, Boehmerle W, K\u00f6rner R et al (2021) Novichok nerve agent poisoning. Lancet Lond Engl 397:249\u2013252. https:\/\/doi.org\/10.1016\/S0140-6736(20)32644-1","journal-title":"Lancet Lond Engl"},{"key":"3408_CR36","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0378-4274(95)03575-3","volume":"82\u201383","author":"P Taylor","year":"1995","unstructured":"Taylor P, Radic Z, Hosea NA et al (1995) Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol Lett 82\u201383:453\u2013458. https:\/\/doi.org\/10.1016\/0378-4274(95)03575-3","journal-title":"Toxicol Lett"},{"key":"3408_CR37","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1080\/15563650.2018.1469759","volume":"56","author":"JA Vale","year":"2018","unstructured":"Vale JA, Marrs TC, Maynard RL (2018) Novichok: a murderous nerve agent attack in the UK. Clin Toxicol Phila Pa 56:1093\u20131097. https:\/\/doi.org\/10.1080\/15563650.2018.1469759","journal-title":"Clin Toxicol Phila Pa"},{"key":"3408_CR38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tox.2007.12.027","volume":"246","author":"V Vallet","year":"2008","unstructured":"Vallet V, Cruz C, Licausi J et al (2008) Percutaneous penetration and distribution of VX using in vitro pig or human excised skin validation of demeton-S-methyl as adequate simulant for VX skin permeation investigations. Toxicology 246:73\u201382. https:\/\/doi.org\/10.1016\/j.tox.2007.12.027","journal-title":"Toxicology"},{"key":"3408_CR39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/s0041-008x(03)00216-3","volume":"191","author":"MJ van der Schans","year":"2003","unstructured":"van der Schans MJ, Lander BJ, van der Wiel H et al (2003) Toxicokinetics of the nerve agent (+\/\u2212)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol Appl Pharmacol 191:48\u201362. https:\/\/doi.org\/10.1016\/s0041-008x(03)00216-3","journal-title":"Toxicol Appl Pharmacol"},{"key":"3408_CR40","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/s0009-8981(99)00144-8","volume":"288","author":"F Worek","year":"1999","unstructured":"Worek F, Mast U, Kiderlen D et al (1999) Improved determination of acetylcholinesterase activity in human whole blood. Clin Chim Acta Int J Clin Chem 288:73\u201390. https:\/\/doi.org\/10.1016\/s0009-8981(99)00144-8","journal-title":"Clin Chim Acta Int J Clin Chem"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03408-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-022-03408-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03408-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T15:07:46Z","timestamp":1674227266000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-022-03408-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["3408"],"URL":"https:\/\/doi.org\/10.1007\/s00204-022-03408-w","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,3]]},"assertion":[{"value":"6 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}