{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:17:48Z","timestamp":1792009068131,"version":"4.4.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T00:00:00Z","timestamp":1671926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003509","name":"\u00d6rebro Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008584","name":"Stiftelsen L\u00e4ngmanska Kulturfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008584","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Knowledge Foundation, Sweden"},{"DOI":"10.13039\/501100010426","name":"UGC-DAE\u00a0Consortium for Scientific Research, University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012099","name":"Indian Institute of Technology, Guwahati","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012099","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003509","name":"\u00d6rebro University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003509","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transthyretin (TTR) is a homo-tetramer protein involved in the transport of thyroid hormone (thyroxine; T4) in the plasma and cerebrospinal fluid. Many pollutants have been shown to bind to TTR, which could be alarming as disruption in the thyroid hormone system can lead to several physiological problems. It is also indicated that the monomerization of tetramer and destabilization of monomer can lead to amyloidogenesis. Many compounds are identified that can bind to tetramer and stabilize the tetramer leading to the inhibition of amyloid fibril formation. Other compounds are known to bind tetramer and induce amyloid fibril formation. Among the pollutants, per- and polyfluoroalkyl substances (PFAS) are known to disrupt the thyroid hormone system. The molecular mechanisms of thyroid hormone disruption could be diverse, as some are known to bind with thyroid hormone receptors, and others can bind to membrane transporters. Binding to TTR could also be one of the important pathways to alter thyroid signaling. However, the molecular interactions that drive thyroid-disrupting effects of long-chain and short-chain PFASs are not comprehensively understood at the molecular level. In this study, using a computational approach, we show that carbon chain length and functional group in PFASs are structural determinants, in which longer carbon chains of PFASs and sulfur-containing PFASs favor stronger interactions with TTR than their shorter-chained counterparts. Interestingly, short-chain PFAS also showed strong binding capacity, and the interaction energy for some was as close to the longer-chain PFAS. This suggests that short-chain PFASs are not completely safe, and their use and build-up in the environment should be carefully regulated. Of note, TTR homologs analysis suggests that thyroid-disrupting effects of PFASs could be most likely translated to TTR-like proteins and other species.<\/jats:p>","DOI":"10.1007\/s00204-022-03434-8","type":"journal-article","created":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T10:02:26Z","timestamp":1671962546000},"page":"755-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["In silico analysis decodes transthyretin (TTR) binding and thyroid disrupting effects of per- and polyfluoroalkyl substances (PFAS)"],"prefix":"10.1007","volume":"97","author":[{"given":"Rupal","family":"Dharpure","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Pramanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-8574","authenticated-orcid":false,"given":"Ajay","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,25]]},"reference":[{"issue":"5","key":"3434_CR1","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1177\/31.5.6341455","volume":"31","author":"SL Aleshire","year":"1983","unstructured":"Aleshire SL, Bradley CA, Richardson LD, Parl FF (1983) Localization of human prealbumin in choroid plexus epithelium. J Histochem Cytochem 31(5):608\u2013612. https:\/\/doi.org\/10.1177\/31.5.6341455","journal-title":"J Histochem Cytochem"},{"issue":"23","key":"3434_CR2","doi-asserted-by":"publisher","first-page":"15103","DOI":"10.1021\/acsomega.1c01304","volume":"6","author":"NM Almeida","year":"2021","unstructured":"Almeida NM, Yi E, Wilson AK (2021) Binding of per-and polyfluoro-alkyl substances to peroxisome proliferator-activated receptor gamma. ACS Omega 6(23):15103\u201315114. https:\/\/doi.org\/10.1021\/acsomega.1c01304","journal-title":"ACS Omega"},{"key":"3434_CR3","unstructured":"Association AT (2019) https:\/\/www.thyroid.org\/media-main\/press-room\/. Bailli\u00e8re, Tindall and Cox"},{"issue":"1","key":"3434_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.nmd.2021.11.013","volume":"32","author":"CE Bekircan-Kurt","year":"2022","unstructured":"Bekircan-Kurt CE, Yilmaz E, Arslan D et al (2022) The functional and structural evaluation of small fibers in asymptomatic carriers of TTR p. Val50Met (Val30Met) mutation. Neuromuscul Disord 32(1):50\u201356. https:\/\/doi.org\/10.1016\/j.nmd.2021.11.013","journal-title":"Neuromuscul Disord"},{"key":"3434_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.envint.2015.01.007","volume":"77","author":"V Berg","year":"2015","unstructured":"Berg V, Nost TH, Hansen S et al (2015) Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach. Environ Int 77:63\u201369. https:\/\/doi.org\/10.1016\/j.envint.2015.01.007","journal-title":"Environ Int"},{"issue":"1","key":"3434_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1758-2946-1-15","volume":"1","author":"Z Bikadi","year":"2009","unstructured":"Bikadi Z, Hazai E (2009) Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock. J Cheminform 1(1):1\u201316. https:\/\/doi.org\/10.1186\/1758-2946-1-15","journal-title":"J Cheminform"},{"issue":"Pt A","key":"3434_CR7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.envpol.2018.07.042","volume":"242","author":"BE Blake","year":"2018","unstructured":"Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK (2018) Associations between longitudinal serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald community cohort. Environ Pollut 242(Pt A):894\u2013904. https:\/\/doi.org\/10.1016\/j.envpol.2018.07.042","journal-title":"Environ Pollut"},{"issue":"1","key":"3434_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12302-018-0134-4","volume":"30","author":"S Brendel","year":"2018","unstructured":"Brendel S, Fetter E, Staude C, Vierke L, Biegel-Engler A (2018) Short-chain perfluoroalkyl acids: environmental concerns and a regulatory strategy under REACH. Environ Sci Eur 30(1):9. https:\/\/doi.org\/10.1186\/s12302-018-0134-4","journal-title":"Environ Sci Eur"},{"issue":"9","key":"3434_CR10","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1172\/JCI60047","volume":"122","author":"GA Brent","year":"2012","unstructured":"Brent GA (2012) Mechanisms of thyroid hormone action. J Clin Investig 122(9):3035\u20133043. https:\/\/doi.org\/10.1172\/JCI60047","journal-title":"J Clin Investig"},{"issue":"8","key":"3434_CR11","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1021\/acs.chemrestox.2c00072","volume":"35","author":"JM Brown-Leung","year":"2022","unstructured":"Brown-Leung JM, Cannon JR (2022) Neurotransmission targets of per-and polyfluoroalkyl substance neurotoxicity: mechanisms and potential implications for adverse neurological outcomes. Chem Res Toxicol 35(8):1312\u20131333. https:\/\/doi.org\/10.1021\/acs.chemrestox.2c00072","journal-title":"Chem Res Toxicol"},{"issue":"4","key":"3434_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/ieam.258","volume":"7","author":"RC Buck","year":"2011","unstructured":"Buck RC, Franklin J, Berger U et al (2011) Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag 7(4):513\u2013541. https:\/\/doi.org\/10.1002\/ieam.258","journal-title":"Integr Environ Assess Manag"},{"key":"3434_CR13","doi-asserted-by":"publisher","first-page":"105048","DOI":"10.1016\/j.envint.2019.105048","volume":"131","author":"AM Calafat","year":"2019","unstructured":"Calafat AM, Kato K, Hubbard K, Jia T, Botelho JC, Wong LY (2019) Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: paired serum-urine data from the 2013\u20132014 national health and nutrition examination survey. Environ Int. 131:105048. https:\/\/doi.org\/10.1016\/j.envint.2019.105048","journal-title":"Environ Int."},{"issue":"4","key":"3434_CR14","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1021\/acs.chemrestox.2c00078","volume":"35","author":"M Camdzic","year":"2022","unstructured":"Camdzic M, Aga DS, Atilla-Gokcumen GE (2022) Cellular interactions and fatty acid transporter CD36-mediated uptake of per-and polyfluorinated alkyl substances (PFAS). Chem Res Toxicol 35(4):694\u2013702. https:\/\/doi.org\/10.1021\/acs.chemrestox.2c00078","journal-title":"Chem Res Toxicol"},{"issue":"9","key":"3434_CR15","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2020.6223","volume":"18","author":"D Schrenk","year":"2020","unstructured":"Chain EPoCitF, Schrenk D, Bignami M et al (2020) Risk to human health related to the presence of perfluoroalkyl substances in food. EFSA J 18(9):e06223. https:\/\/doi.org\/10.2903\/j.efsa.2020.6223","journal-title":"EFSA J"},{"key":"3434_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2021.732436","volume":"3","author":"WS Chambers","year":"2021","unstructured":"Chambers WS, Hopkins JG, Richards SM (2021) A review of per- and polyfluorinated alkyl substance impairment of reproduction. Front Toxicol 3:732436. https:\/\/doi.org\/10.3389\/ftox.2021.732436","journal-title":"Front Toxicol"},{"issue":"2","key":"3434_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jchf.2021.09.006","volume":"10","author":"AC Coniglio","year":"2022","unstructured":"Coniglio AC, Segar MW, Loungani RS et al (2022) Transthyretin V142I genetic variant and cardiac remodeling, injury, and heart failure risk in black adults. JACC Heart Fail 10(2):129\u2013138. https:\/\/doi.org\/10.1016\/j.jchf.2021.09.006","journal-title":"JACC Heart Fail"},{"key":"3434_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.612320","volume":"11","author":"F Coperchini","year":"2021","unstructured":"Coperchini F, Croce L, Ricci G et al (2021) Thyroid disrupting effects of old and new generation PFAS. Front Endocrinol 11:612320. https:\/\/doi.org\/10.3389\/fendo.2020.612320","journal-title":"Front Endocrinol"},{"issue":"4","key":"3434_CR19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1071\/EN10144","volume":"8","author":"DK Cousins","year":"2011","unstructured":"Cousins DK, Vestergren R (2011) Reconciling measurement and modelling studies of the sources and fate of perfluorinated carboxylates. Environ Chem 8(4):339\u2013354. https:\/\/doi.org\/10.1071\/EN10144","journal-title":"Environ Chem"},{"key":"3434_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115976","author":"DN Cui","year":"2020","unstructured":"Cui DN, Li XR, Quinete N (2020) Occurrence, fate, sources and toxicity of PFAS: what we know so far in Florida and major gaps. Trac-Trend Anal Chem. https:\/\/doi.org\/10.1016\/j.trac.2020.115976","journal-title":"Trac-Trend Anal Chem"},{"issue":"9","key":"3434_CR21","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1289\/ehp.0900633","volume":"117","author":"R Dallaire","year":"2009","unstructured":"Dallaire R, Dewailly E, Pereg D, Dery S, Ayotte P (2009) Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect 117(9):1380\u20131386. https:\/\/doi.org\/10.1289\/ehp.0900633","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3434_CR500","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/etc.4890","volume":"40","author":"SE Fenton","year":"2021","unstructured":"Fenton SE, Ducatman A, Boobis A et al (2021) Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research. Environ Toxicol Chem 40(3):606\u2013630. https:\/\/doi.org\/10.1002\/etc.4890","journal-title":"Environ Toxicol Chem"},{"issue":"3","key":"3434_CR24","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S0749-3797(00)00317-2","volume":"20","author":"H Frumkin","year":"2001","unstructured":"Frumkin H (2001) Beyond toxicity: human health and the natural environment. Am J Prev Med 20(3):234\u2013240. https:\/\/doi.org\/10.1016\/S0749-3797(00)00317-2","journal-title":"Am J Prev Med"},{"key":"3434_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.biochi.2019.02.003","volume":"160","author":"M Godlewska","year":"2019","unstructured":"Godlewska M, Banga PJ (2019) Thyroid peroxidase as a dual active site enzyme: focus on biosynthesis, hormonogenesis and thyroid disorders of autoimmunity and cancer. Biochimie 160:34\u201345. https:\/\/doi.org\/10.1016\/j.biochi.2019.02.003","journal-title":"Biochimie"},{"key":"3434_CR26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.envint.2018.04.025","volume":"116","author":"W Han","year":"2018","unstructured":"Han W, Gao Y, Yao Q et al (2018) Perfluoroalkyl and polyfluoroalkyl substances in matched parental and cord serum in Shandong, China. Environ Int 116:206\u2013213. https:\/\/doi.org\/10.1016\/j.envint.2018.04.025","journal-title":"Environ Int"},{"issue":"4","key":"3434_CR27","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1002\/prot.21033","volume":"64","author":"SC Hennebry","year":"2006","unstructured":"Hennebry SC, Wright HM, Likic VA, Richardson SJ (2006) Structural and functional evolution of transthyretin and transthyretin-like proteins. Proteins 64(4):1024\u20131045. https:\/\/doi.org\/10.1002\/prot.21033","journal-title":"Proteins"},{"issue":"6","key":"3434_CR28","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.neuron.2018.08.011","volume":"99","author":"SA Hollingsworth","year":"2018","unstructured":"Hollingsworth SA, Dror RO (2018) Molecular dynamics simulation for all. Neuron 99(6):1129\u20131143. https:\/\/doi.org\/10.1016\/j.neuron.2018.08.011","journal-title":"Neuron"},{"key":"3434_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2147\/AABC.S70333","volume":"8","author":"A Hospital","year":"2015","unstructured":"Hospital A, Goni JR, Orozco M, Gelpi JL (2015) Molecular dynamics simulations: advances and applications. Adv Appl Bioinform Chem 8:37\u201347. https:\/\/doi.org\/10.2147\/AABC.S70333","journal-title":"Adv Appl Bioinform Chem"},{"key":"3434_CR30","first-page":"54","volume":"8","author":"R Huey","year":"2008","unstructured":"Huey R, Morris GM (2008) Using AutoDock 4 with AutoDocktools: a tutorial. Scripps Res Inst USA 8:54\u201356","journal-title":"Scripps Res Inst USA"},{"issue":"10","key":"3434_CR31","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41574-019-0237-z","volume":"15","author":"K Ikegami","year":"2019","unstructured":"Ikegami K, Refetoff S, Van Cauter E, Yoshimura T (2019) Interconnection between circadian clocks and thyroid function. Nat Rev Endocrinol 15(10):590\u2013600. https:\/\/doi.org\/10.1038\/s41574-019-0237-z","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"3434_CR32","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1093\/bioinformatics\/btaa849","volume":"37","author":"G Janson","year":"2021","unstructured":"Janson G, Paiardini A (2021) PyMod 3: a complete suite for structural bioinformatics in PyMOL. Bioinformatics 37(10):1471\u20131472. https:\/\/doi.org\/10.1093\/bioinformatics\/btaa849","journal-title":"Bioinformatics"},{"key":"3434_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12302-018-0134-4","author":"AA Jensen","year":"2015","unstructured":"Jensen AA, Warming M (2015) Short-chain polyfluoroalkyl substances (PFAS). DEPA. https:\/\/doi.org\/10.1186\/s12302-018-0134-4","journal-title":"DEPA"},{"key":"3434_CR34","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.chemosphere.2017.06.024","volume":"184","author":"S Kar","year":"2017","unstructured":"Kar S, Sepulveda MS, Roy K, Leszczynski J (2017) Endocrine-disrupting activity of per- and polyfluoroalkyl substances: exploring combined approaches of ligand and structure based modeling. Chemosphere 184:514\u2013523. https:\/\/doi.org\/10.1016\/j.chemosphere.2017.06.024","journal-title":"Chemosphere"},{"issue":"19","key":"3434_CR35","doi-asserted-by":"publisher","first-page":"8037","DOI":"10.1021\/es1043613","volume":"45","author":"K Kato","year":"2011","unstructured":"Kato K, Wong LY, Jia LT, Kuklenyik Z, Calafat AM (2011) Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999\u20132008. Environ Sci Technol 45(19):8037\u201345. https:\/\/doi.org\/10.1021\/es1043613","journal-title":"Environ Sci Technol"},{"issue":"52","key":"3434_CR36","doi-asserted-by":"publisher","first-page":"12952","DOI":"10.1021\/ja971836d","volume":"119","author":"KS Kim","year":"1997","unstructured":"Kim KS, Friesner RA (1997) Hydrogen bonding between amino acid backbone and side chain analogues: a high-level ab initio study. J Am Chem Soc 119(52):12952\u201312961. https:\/\/doi.org\/10.1021\/ja971836d","journal-title":"J Am Chem Soc"},{"issue":"6","key":"3434_CR37","doi-asserted-by":"publisher","first-page":"12261","DOI":"10.3390\/ijms160612261","volume":"16","author":"HJ Kim","year":"2015","unstructured":"Kim HJ, Koedrith P, Seo YR (2015) Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism. Int J Mol Sci 16(6):12261\u201312287. https:\/\/doi.org\/10.3390\/ijms160612261","journal-title":"Int J Mol Sci"},{"issue":"D1","key":"3434_CR38","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","volume":"44","author":"S Kim","year":"2016","unstructured":"Kim S, Thiessen PA, Bolton EE et al (2016) PubChem substance and compound databases. Nucleic Acids Res 44(D1):D1202\u2013D1213. https:\/\/doi.org\/10.1093\/nar\/gkv951","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"3434_CR39","doi-asserted-by":"publisher","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","volume":"47","author":"S Kim","year":"2019","unstructured":"Kim S, Chen J, Cheng TJ et al (2019) PubChem 2019 update: improved access to chemical data. Nucleic Acids Res 47(D1):D1102\u2013D1109. https:\/\/doi.org\/10.1093\/nar\/gky1033","journal-title":"Nucleic Acids Res"},{"key":"3434_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116929","volume":"279","author":"S Kim","year":"2021","unstructured":"Kim S, Thapar I, Brooks BW (2021) Epigenetic changes by per-and polyfluoroalkyl substances (PFAS). Environ Pollut 279:116929. https:\/\/doi.org\/10.1016\/j.envpol.2021.116929","journal-title":"Environ Pollut"},{"issue":"7","key":"3434_CR41","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0192-0561(00)00012-6","volume":"22","author":"AJ Klecha","year":"2000","unstructured":"Klecha AJ, Genaro AM, Lysionek AE, Caro RA, Coluccia AG, Cremaschi GA (2000) Experimental evidence pointing to the bidirectional interaction between the immune system and the thyroid axis. Int J Immunopharmacol 22(7):491\u2013500. https:\/\/doi.org\/10.1016\/S0192-0561(00)00012-6","journal-title":"Int J Immunopharmacol"},{"issue":"19","key":"3434_CR42","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1038\/sj.onc.1204300","volume":"20","author":"L Kockel","year":"2001","unstructured":"Kockel L, Homsy JG, Bohmann D (2001) Drosophila AP-1: lessons from an invertebrate. Oncogene 20(19):2347\u20132364","journal-title":"Oncogene"},{"key":"3434_CR43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.39705","volume":"8","author":"MM Konate","year":"2019","unstructured":"Konate MM, Plata G, Park J, Usmanova DR, Wang H, Vitkup D (2019) Molecular function limits divergent protein evolution on planetary timescales. Elife 8:e39705. https:\/\/doi.org\/10.7554\/eLife.39705","journal-title":"Elife"},{"issue":"20","key":"3434_CR44","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1093\/bioinformatics\/btu426","volume":"30","author":"E Krieger","year":"2014","unstructured":"Krieger E, Vriend G (2014) YASARA view-molecular graphics for all devices-from smartphones to workstations. Bioinformatics 30(20):2981\u20132982. https:\/\/doi.org\/10.1093\/bioinformatics\/btu426","journal-title":"Bioinformatics"},{"issue":"8","key":"3434_CR45","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1021\/acs.estlett.0c00255","volume":"7","author":"CF Kwiatkowski","year":"2020","unstructured":"Kwiatkowski CF, Andrews DQ, Birnbaum LS et al (2020) Scientific basis for managing PFAS as a chemical class. Environ Sci Technol Lett 7(8):532\u2013543. https:\/\/doi.org\/10.1021\/acs.estlett.0c00255","journal-title":"Environ Sci Technol Lett"},{"key":"3434_CR46","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.34","author":"I Ladunga","year":"2009","unstructured":"Ladunga I (2009) Finding homologs in amino acid sequences using network BLAST searches. Curr Protoc Bioinform. https:\/\/doi.org\/10.1002\/cpbi.34","journal-title":"Curr Protoc Bioinform"},{"key":"3434_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-1-4939-7366-8_4","volume":"1685","author":"H Land","year":"2018","unstructured":"Land H, Humble MS (2018) YASARA: A tool to obtain structural guidance in biocatalytic investigations. Methods Mol Biol 1685:43\u201367. https:\/\/doi.org\/10.1007\/978-1-4939-7366-8_4","journal-title":"Methods Mol Biol"},{"issue":"10","key":"3434_CR48","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1021\/ci200227u","volume":"51","author":"RA Laskowski","year":"2011","unstructured":"Laskowski RA, Swindells MB (2011) LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J Chem Inf Model 51(10):2778\u20132786. https:\/\/doi.org\/10.1021\/ci200227u","journal-title":"J Chem Inf Model"},{"issue":"2","key":"3434_CR49","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1093\/toxsci\/kfm128","volume":"99","author":"C Lau","year":"2007","unstructured":"Lau C, Anitole K, Hodes C, Lai D, Pfahles-Hutchens A, Seed J (2007) Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicol Sci 99(2):366\u2013394. https:\/\/doi.org\/10.1093\/toxsci\/kfm128","journal-title":"Toxicol Sci"},{"key":"3434_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/B978-0-12-821044-4.00021-2","volume-title":"Biochemical and molecular basis of toxicity Haschek and Rousseaux\u2019s handbook of toxicologic pathology","author":"LD Lehman-McKeeman","year":"2022","unstructured":"Lehman-McKeeman LD, Armstrong LE (2022) Biochemical and molecular basis of toxicity Haschek and Rousseaux\u2019s handbook of toxicologic pathology. Elsevier, Academic Press, pp 15\u201349"},{"key":"3434_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.122506","volume":"380","author":"F Li","year":"2020","unstructured":"Li F, Duan J, Tian S et al (2020) Short-chain per-and polyfluoroalkyl substances in aquatic systems: occurrence, impacts and treatment. Chem Eng J 380:122506. https:\/\/doi.org\/10.1016\/j.cej.2019.122506","journal-title":"Chem Eng J"},{"issue":"19","key":"3434_CR52","doi-asserted-by":"publisher","first-page":"7954","DOI":"10.1021\/es2011622","volume":"45","author":"AB Lindstrom","year":"2011","unstructured":"Lindstrom AB, Strynar MJ, Libelo EL (2011) Polyfluorinated compounds: past, present, and future. Environ Sci Technol 45(19):7954\u20137961. https:\/\/doi.org\/10.1021\/es2011622","journal-title":"Environ Sci Technol"},{"issue":"34","key":"3434_CR53","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1523\/JNEUROSCI.1746-04.2004","volume":"24","author":"J Lipton","year":"2004","unstructured":"Lipton J, Kleemann G, Ghosh R, Lints R, Emmons SW (2004) Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate. J Neurosci 24(34):7427\u20137434","journal-title":"J Neurosci"},{"issue":"1","key":"3434_CR54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10646-010-0555-3","volume":"20","author":"Y Liu","year":"2011","unstructured":"Liu Y, Wang J, Fang X, Zhang H, Dai J (2011) The thyroid-disrupting effects of long-term perfluorononanoate exposure on zebrafish (Danio rerio). Ecotoxicology 20(1):47\u201355. https:\/\/doi.org\/10.1007\/s10646-010-0555-3","journal-title":"Ecotoxicology"},{"issue":"2","key":"3434_CR55","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s40120-020-00217-0","volume":"9","author":"MA Liz","year":"2020","unstructured":"Liz MA, Coelho T, Bellotti V, Fernandez-Arias MI, Mallaina P, Obici L (2020) A narrative review of the role of transthyretin in health and disease. Neurol Ther 9(2):395\u2013402. https:\/\/doi.org\/10.1007\/s40120-020-00217-0","journal-title":"Neurol Ther"},{"issue":"7","key":"3434_CR56","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1289\/ehp.1104370","volume":"120","author":"MJ Lopez-Espinosa","year":"2012","unstructured":"Lopez-Espinosa MJ, Mondal D, Armstrong B, Bloom MS, Fletcher T (2012) Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ Health Perspect 120(7):1036\u20131041. https:\/\/doi.org\/10.1289\/ehp.1104370","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3434_CR57","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cbi.2005.06.007","volume":"155","author":"JW Martin","year":"2005","unstructured":"Martin JW, Mabury SA, O\u2019Brien PJ (2005) Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes. Chem Biol Interact 155(3):165\u2013180. https:\/\/doi.org\/10.1016\/j.cbi.2005.06.007","journal-title":"Chem Biol Interact"},{"issue":"5","key":"3434_CR58","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1289\/ehp.0901584","volume":"118","author":"D Melzer","year":"2010","unstructured":"Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010) Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National health and nutrition examination survey. Environ Health Perspect 118(5):686\u201392. https:\/\/doi.org\/10.1289\/ehp.0901584","journal-title":"Environ Health Perspect"},{"key":"3434_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.comtox.2020.100120","volume":"13","author":"\u212b-K Mortensen","year":"2020","unstructured":"Mortensen \u212b-K, M\u00e6hre S, Kristiansen K et al (2020) Homology modeling to screen for potential binding of contaminants to thyroid hormone receptor and transthyretin in glaucous gull (Larus hyperboreus) and herring gull (Larus argentatus). Comput Toxicol 13:100120. https:\/\/doi.org\/10.1016\/j.comtox.2020.100120","journal-title":"Comput Toxicol"},{"key":"3434_CR60","doi-asserted-by":"publisher","first-page":"197","DOI":"10.4103\/2230-8210.83329","volume":"2","author":"B Mounika","year":"2013","unstructured":"Mounika B, Brahmaiah B, Ramesh M, Bhavaneshwari K, Anantha Lakshmi T, Nama S (2013) Review on thyroid disorders. Int J Pharm Res Bio-Sci 2:197\u2013214. https:\/\/doi.org\/10.4103\/2230-8210.83329","journal-title":"Int J Pharm Res Bio-Sci"},{"issue":"4","key":"3434_CR61","doi-asserted-by":"publisher","first-page":"R160","DOI":"10.1530\/EC-18-0029","volume":"7","author":"BB Mughal","year":"2018","unstructured":"Mughal BB, Fini JB, Demeneix BA (2018) Thyroid-disrupting chemicals and brain development: an update. Endocr Connect 7(4):R160\u2013R186. https:\/\/doi.org\/10.1530\/EC-18-0029","journal-title":"Endocr Connect"},{"issue":"2","key":"3434_CR62","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1152\/physrev.00030.2013","volume":"94","author":"R Mullur","year":"2014","unstructured":"Mullur R, Liu YY, Brent GA (2014) Thyroid hormone regulation of metabolism. Physiol Rev 94(2):355\u2013382. https:\/\/doi.org\/10.1152\/physrev.00030.2013","journal-title":"Physiol Rev"},{"key":"3434_CR63","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cotox.2021.02.001","volume":"25","author":"M Neagu","year":"2021","unstructured":"Neagu M, Constantin C, Bardi G, Duraes L (2021) Adverse outcome pathway in immunotoxicity of perfluoroalkyls. Curr Opin Toxicol 25:23\u201329. https:\/\/doi.org\/10.1016\/j.cotox.2021.02.001","journal-title":"Curr Opin Toxicol"},{"key":"3434_CR64","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"NM O'Boyle","year":"2011","unstructured":"O\u2019Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR (2011) Open babel: an open chemical toolbox. J Cheminform 3:33. https:\/\/doi.org\/10.1186\/1758-2946-3-33","journal-title":"J Cheminform"},{"key":"3434_CR65","unstructured":"OECD (2020) PFASs and Alternatives in Food Packaging (Paper and Paperboard) Report on the Commercial Availability and Current Uses, OECD Series on Risk Management. EHS OECD No. 58."},{"key":"3434_CR66","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.envres.2017.05.013","volume":"157","author":"GW Olsen","year":"2017","unstructured":"Olsen GW, Mair DC, Lange CC et al (2017) Per- and polyfluoroalkyl substances (PFAS) in American red cross adult blood donors, 2000\u20132015. Environ Res 157:87\u201395. https:\/\/doi.org\/10.1016\/j.envres.2017.05.013","journal-title":"Environ Res"},{"issue":"14","key":"3434_CR67","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1001\/jama.2022.2896","volume":"327","author":"V Parcha","year":"2022","unstructured":"Parcha V, Malla G, Ivin MR et al (2022) Association of transthyretin Val122Ile variant with incident heart failure among black individuals. JAMA 327(14):1368\u20131378. https:\/\/doi.org\/10.1001\/jama.2022.2896","journal-title":"JAMA"},{"issue":"3","key":"3434_CR68","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/gcen.2000.7520","volume":"119","author":"D Power","year":"2000","unstructured":"Power D, Elias N, Richardson S, Mendes J, Soares C, Santos C (2000) Evolution of the thyroid hormone-binding protein, transthyretin. Gen Comp Endocrinol 119(3):241\u2013255. https:\/\/doi.org\/10.1006\/gcen.2000.7520","journal-title":"Gen Comp Endocrinol"},{"issue":"2","key":"3434_CR69","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5582\/bst.2016.01252","volume":"11","author":"S Pramanik","year":"2017","unstructured":"Pramanik S, Kutzner A, Heese K (2017) Livebearing or egg-laying mammals: 27 decisive nucleotides of FAM168. Biosci Trends 11(2):169\u2013178. https:\/\/doi.org\/10.5582\/bst.2016.01252","journal-title":"Biosci Trends"},{"issue":"19","key":"3434_CR70","doi-asserted-by":"publisher","first-page":"5330","DOI":"10.1111\/j.1742-4658.2009.07243.x","volume":"276","author":"P Prapunpoj","year":"2009","unstructured":"Prapunpoj P, Leelawatwattana L (2009) Evolutionary changes to transthyretin: structure-function relationships. FEBS J 276(19):5330\u20135341. https:\/\/doi.org\/10.1111\/j.1742-4658.2009.07243.x","journal-title":"FEBS J"},{"issue":"4\u20135","key":"3434_CR71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/10520290701510288","volume":"82","author":"P Prento","year":"2007","unstructured":"Prento P (2007) The role of glycine and prolines in connective tissue fiber staining with hydrogen bonding dyes. Biotech Histochem 82(4\u20135):199\u2013200. https:\/\/doi.org\/10.1080\/10520290701510288","journal-title":"Biotech Histochem"},{"key":"3434_CR72","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-1-0716-1036-7_13","volume":"2231","author":"JB Procter","year":"2021","unstructured":"Procter JB, Carstairs GM, Soares B et al (2021) Alignment of biological sequences with jalview. Methods Mol Biol 2231:203\u2013224. https:\/\/doi.org\/10.1007\/978-1-0716-1036-7_13","journal-title":"Methods Mol Biol"},{"key":"3434_CR73","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3389\/fendo.2019.00506","volume":"10","author":"SA Rabah","year":"2019","unstructured":"Rabah SA, Gowan IL, Pagnin M, Osman N, Richardson SJ (2019) Thyroid hormone distributor proteins during development in vertebrates. Front Endocrinol 10:506. https:\/\/doi.org\/10.3389\/fendo.2019.00506","journal-title":"Front Endocrinol"},{"issue":"1","key":"3434_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbapap.2004.09.023","volume":"1703","author":"P Raghu","year":"2004","unstructured":"Raghu P, Sivakumar B (2004) Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin a homeostasis and transthyretin amyloidosis. Biochim Biophys Acta Proteins Proteom 1703(1):1\u20139. https:\/\/doi.org\/10.1016\/j.bbapap.2004.09.023","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"3434_CR75","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.tox.2016.08.011","volume":"366","author":"X-M Ren","year":"2016","unstructured":"Ren X-M, Qin W-P, Cao L-Y et al (2016) Binding interactions of perfluoroalkyl substances with thyroid hormone transport proteins and potential toxicological implications. Toxicology 366:32\u201342. https:\/\/doi.org\/10.1016\/j.tox.2016.08.011","journal-title":"Toxicology"},{"issue":"6","key":"3434_CR77","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1021\/acs.chemrestox.1c00101","volume":"34","author":"Y Rericha","year":"2021","unstructured":"Rericha Y, Cao D, Truong L, Simonich M, Field JA, Tanguay RL (2021) Behavior effects of structurally diverse per-and polyfluoroalkyl substances in zebrafish. Chem Res Toxicol 34(6):1409\u20131416. https:\/\/doi.org\/10.1021\/acs.chemrestox.1c00101","journal-title":"Chem Res Toxicol"},{"key":"3434_CR78","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3389\/fnins.2015.00066","volume":"9","author":"SJ Richardson","year":"2015","unstructured":"Richardson SJ, Wijayagunaratne RC, D\u2019Souza DG, Darras VM, Van Herck SL (2015) Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane transporters. Front Neurosci 9:66. https:\/\/doi.org\/10.3389\/fnins.2015.00066","journal-title":"Front Neurosci"},{"key":"3434_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153031","volume":"465","author":"BP Rickard","year":"2022","unstructured":"Rickard BP, Rizvi I, Fenton SE (2022) Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease. Toxicology 465:153031. https:\/\/doi.org\/10.1016\/j.tox.2021.153031","journal-title":"Toxicology"},{"issue":"6","key":"3434_CR80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003659","volume":"10","author":"MH Schaefer","year":"2014","unstructured":"Schaefer MH, Yang J-S, Serrano L, Kiel C (2014) Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways. PLOS Comput Biol 10(6):e1003659. https:\/\/doi.org\/10.1371\/journal.pcbi.1003659","journal-title":"PLOS Comput Biol"},{"issue":"5","key":"3434_CR81","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","volume":"24","author":"D Seeliger","year":"2010","unstructured":"Seeliger D, de Groot BL (2010) Ligand docking and binding site analysis with PyMOL and Autodock\/Vina. J Comput Aided Mol Des 24(5):417\u2013422. https:\/\/doi.org\/10.1007\/s10822-010-9352-6","journal-title":"J Comput Aided Mol Des"},{"issue":"6","key":"3434_CR82","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1073\/pnas.0409522102","volume":"102","author":"R Sharan","year":"2005","unstructured":"Sharan R, Suthram S, Kelley RM et al (2005) Conserved patterns of protein interaction in multiple species. Proc Natl Acad Sci USA 102(6):1974\u20131979. https:\/\/doi.org\/10.1073\/pnas.0409522102","journal-title":"Proc Natl Acad Sci USA"},{"key":"3434_CR83","doi-asserted-by":"publisher","first-page":"3.1.31","DOI":"10.1002\/0471250953.bi0313s48","volume":"48","author":"F Sievers","year":"2014","unstructured":"Sievers F, Higgins DG (2014) Clustal omega. Curr Protoc Bioinform 48:3.1.31-16. https:\/\/doi.org\/10.1002\/0471250953.bi0313s48","journal-title":"Curr Protoc Bioinform"},{"key":"3434_CR84","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2022.2056011","author":"Y Takahashi","year":"2022","unstructured":"Takahashi Y, Ohashi N, Takasone K et al (2022) CSF\/plasma levels, transthyretin stabilisation and safety of multiple doses of tolcapone in subjects with hereditary ATTR amyloidosis. Amyloid. https:\/\/doi.org\/10.1080\/13506129.2022.2056011","journal-title":"Amyloid"},{"issue":"2","key":"3434_CR85","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1093\/toxsci\/kfg121","volume":"74","author":"JR Thibodeaux","year":"2003","unstructured":"Thibodeaux JR, Hanson RG, Rogers JM et al (2003) Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. Toxicol Sci 74(2):369\u201381. https:\/\/doi.org\/10.1093\/toxsci\/kfg121","journal-title":"Toxicol Sci"},{"key":"3434_CR86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043522","author":"D Tomar","year":"2012","unstructured":"Tomar D, Khan T, Singh RR et al (2012) Crystallographic study of novel transthyretin ligands exhibiting negative-cooperativity between two thyroxine binding sites. Plos One. https:\/\/doi.org\/10.1371\/journal.pone.0043522","journal-title":"Plos One"},{"issue":"9","key":"3434_CR87","doi-asserted-by":"publisher","first-page":"3428","DOI":"10.1080\/07391102.2020.1763202","volume":"39","author":"KD Umesh","year":"2021","unstructured":"Umesh KD, Selvaraj C, Singh SK, Dubey VK (2021) Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target. J Biomol Struct Dyn 39(9):3428\u20133434. https:\/\/doi.org\/10.1080\/07391102.2020.1763202","journal-title":"J Biomol Struct Dyn"},{"issue":"1","key":"3434_CR88","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/jhered\/esy059","volume":"110","author":"T Vanderlinde","year":"2019","unstructured":"Vanderlinde T, Dupim EG, Nazario-Yepiz NO, Carvalho AB (2019) An improved genome assembly for Drosophila navojoa, the basal species in the mojavensis cluster. J Hered 110(1):118\u2013123","journal-title":"J Hered"},{"issue":"1","key":"3434_CR89","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1515\/bmc-2013-0038","volume":"5","author":"M Vieira","year":"2014","unstructured":"Vieira M, Saraiva MJ (2014) Transthyretin: a multifaceted protein. Biomol Concepts 5(1):45\u201354. https:\/\/doi.org\/10.1515\/bmc-2013-0038","journal-title":"Biomol Concepts"},{"key":"3434_CR90","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.envint.2014.04.006","volume":"69","author":"Z Wang","year":"2014","unstructured":"Wang Z, Cousins IT, Scheringer M, Buck RC, Hungerbuhler K (2014) Global emission inventories for C4\u2013C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, part II: the remaining pieces of the puzzle. Environ Int 69:166\u2013176. https:\/\/doi.org\/10.1016\/j.envint.2014.04.006","journal-title":"Environ Int"},{"key":"3434_CR91","doi-asserted-by":"publisher","DOI":"10.1039\/D1EW00851J","author":"Y Wang","year":"2022","unstructured":"Wang Y, Kim J, Huang C-H et al (2022) Occurrence of per-and polyfluoroalkyl substances in water: a review. Environ Sci Water Res Technol. https:\/\/doi.org\/10.1039\/D1EW00851J","journal-title":"Environ Sci Water Res Technol"},{"key":"3434_CR92","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.envres.2014.06.012","volume":"133","author":"GM Webster","year":"2014","unstructured":"Webster GM, Venners SA, Mattman A, Martin JW (2014) Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study. Environ Res 133:338\u2013347. https:\/\/doi.org\/10.1016\/j.envres.2014.06.012","journal-title":"Environ Res"},{"issue":"2","key":"3434_CR93","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1093\/toxsci\/kfp055","volume":"109","author":"JM Weiss","year":"2009","unstructured":"Weiss JM, Andersson PL, Lamoree MH, Leonards PE, van Leeuwen SP, Hamers T (2009) Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin. Toxicol Sci 109(2):206\u2013216. https:\/\/doi.org\/10.1093\/toxsci\/kfp055","journal-title":"Toxicol Sci"},{"issue":"6","key":"3434_CR94","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1365-2826.2008.01733.x","volume":"20","author":"GR Williams","year":"2008","unstructured":"Williams GR (2008) Neurodevelopmental and neurophysiological actions of thyroid hormone. J Neuroendocrinol 20(6):784\u2013794. https:\/\/doi.org\/10.1111\/j.1365-2826.2008.01733.x","journal-title":"J Neuroendocrinol"},{"issue":"Pt 7","key":"3434_CR95","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1107\/S0907444901006047","volume":"57","author":"A Wojtczak","year":"2001","unstructured":"Wojtczak A, Neumann P, Cody V (2001) Structure of a new polymorphic monoclinic form of human transthyretin at 3 A resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR. Acta Crystallogr D Biol Crystallogr 57(Pt 7):957\u2013967. https:\/\/doi.org\/10.1107\/S0907444901006047","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"1","key":"3434_CR96","doi-asserted-by":"publisher","first-page":"dvac004","DOI":"10.1093\/eep\/dvac004","volume":"8","author":"Y Xu","year":"2022","unstructured":"Xu Y, Lindh CH, Fletcher T, Jakobsson K, Engstr\u00f6m K (2022) Perfluoroalkyl substances influence DNA methylation in school-age children highly exposed through drinking water contaminated from firefighting foam: a cohort study in Ronneby, Sweden. Environ Epigenet 8(1):dvac004. https:\/\/doi.org\/10.1093\/eep\/dvac004","journal-title":"Environ Epigenet"},{"issue":"1","key":"3434_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-08609-z","volume":"10","author":"AW Yee","year":"2019","unstructured":"Yee AW, Aldeghi M, Blakeley MP et al (2019) A molecular mechanism for transthyretin amyloidogenesis. Nat Commun 10(1):1\u201310. https:\/\/doi.org\/10.1038\/s41467-019-08609-z","journal-title":"Nat Commun"},{"issue":"5","key":"3434_CR98","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1897\/08-345.1","volume":"28","author":"WG Yu","year":"2009","unstructured":"Yu WG, Liu W, Jin YH (2009) Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environ Toxicol Chem 28(5):990\u2013996. https:\/\/doi.org\/10.1897\/08-345.1","journal-title":"Environ Toxicol Chem"},{"key":"3434_CR99","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.envint.2019.03.002","volume":"126","author":"Z Zeng","year":"2019","unstructured":"Zeng Z, Song B, Xiao R et al (2019) Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies. Environ Int 126:598\u2013610. https:\/\/doi.org\/10.1016\/j.envint.2019.03.002","journal-title":"Environ Int"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03434-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-022-03434-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-022-03434-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,26]],"date-time":"2023-02-26T23:17:52Z","timestamp":1677453472000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-022-03434-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,25]]},"references-count":96,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["3434"],"URL":"https:\/\/doi.org\/10.1007\/s00204-022-03434-8","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,25]]},"assertion":[{"value":"22 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}