{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:22:22Z","timestamp":1788963742711,"version":"build-2803163510"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["17H06396"],"award-info":[{"award-number":["17H06396"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["19H04279"],"award-info":[{"award-number":["19H04279"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tokyo University of Science"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acrylamide is an environmental electrophile that has been produced in large amounts for many years. There is concern about the adverse health effects of acrylamide exposure due to its widespread industrial use and also presence in commonly consumed foods and others. <jats:italic>IL-1\u03b2<\/jats:italic> is a key cytokine that protects the brain from inflammatory insults, but its role in acrylamide-induced neurotoxicity remains unknown. We reported recently that deletion of <jats:italic>IL-1\u03b2<\/jats:italic> gene exacerbates ACR-induced neurotoxicity in mice. The aim of this study was to identify genes or signaling pathway(s) involved in enhancement of ACR-induced neurotoxicity by <jats:italic>IL-1\u03b2<\/jats:italic> gene deletion or ACR-induced neurotoxicity to generate a hypothesis mechanism explaining ACR-induced neurotoxicity. C57BL\/6\u00a0J wild-type and <jats:italic>IL-1\u03b2<\/jats:italic> KO mice were exposed to ACR at 0, 12.5, 25\u00a0mg\/kg by oral gavage for 7\u00a0days\/week for 4\u00a0weeks, followed by extraction of mRNA from mice cerebral cortex for RNA sequence analysis. IL-1\u03b2 deletion altered the expression of genes involved in extracellular region, including upregulation of PFN1 gene related to amyotrophic lateral sclerosis and increased the expression of the opposite strand of IL-1\u03b2. Acrylamide exposure enhanced mitochondria oxidative phosphorylation, synapse and ribosome pathways, and activated various pathways of different neurodegenerative diseases, such as Alzheimer disease, Parkinson disease, Huntington disease, and prion disease. Protein network analysis suggested the involvement of different proteins in related to learning and cognitive function, such as Egr1, Egr2, Fos, Nr4a1, and Btg2. Our results identified possible pathways involved in IL-1\u03b2 deletion-potentiated and ACR-induced neurotoxicity in mice.<\/jats:p>","DOI":"10.1007\/s00204-023-03627-9","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T15:02:21Z","timestamp":1700146941000},"page":"181-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1\u03b2-knockout mice"],"prefix":"10.1007","volume":"98","author":[{"given":"Alzahraa","family":"Fergany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick Adams","family":"Ekuban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ueha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Shichino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahoko","family":"Ichihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-5300","authenticated-orcid":false,"given":"Gaku","family":"Ichihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"3627_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1098-1136(200010)32:1<1::AID-GLIA10>3.0.CO;2-W","volume":"32","author":"CM Anderson","year":"2000","unstructured":"Anderson CM, Swanson RA (2000) Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1\u201314","journal-title":"Glia"},{"key":"3627_CR2","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1093\/hmg\/ddv133","volume":"24","author":"C Angebault","year":"2015","unstructured":"Angebault C, Charif M, Guegen N et al (2015) Mutation in NDUFA13\/GRIM19 leads to early onset hypotonia, dyskinesia and sensorial deficiencies, and mitochondrial complex I instability. Hum Mol Genet 24:3948\u20133955","journal-title":"Hum Mol Genet"},{"key":"3627_CR3","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1111\/cas.14975","volume":"112","author":"H Aoki","year":"2021","unstructured":"Aoki H, Ueha S, Nakamura Y et al (2021) Greater extent of blood-tumor TCR repertoire overlap is associated with favorable clinical responses to PD-1 blockade. Cancer Sci 112:2993\u20133004","journal-title":"Cancer Sci"},{"key":"3627_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1172\/JCI120848","volume":"129","author":"E Area-Gomez","year":"2019","unstructured":"Area-Gomez E, Guardia-Laguarta C, Schon EA, Przedborski S (2019) Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas. J Clin Investig 129:34\u201345","journal-title":"J Clin Investig"},{"key":"3627_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner M, Ball CA, Blake JA et al (2000) Gene Ontology: tool for the unification of biology. Nat Genet 25:25\u201329","journal-title":"Nat Genet"},{"key":"3627_CR6","first-page":"652","volume":"96","author":"RB Auld","year":"1967","unstructured":"Auld RB, Bedwell SF (1967) Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide. Can Med Assoc J 96:652","journal-title":"Can Med Assoc J"},{"key":"3627_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00072","author":"VN Barros","year":"2015","unstructured":"Barros VN, Mundim M, Galindo LT, Bittencourt S, Porcionatto M, Mello LE (2015) The pattern of c-Fos expression and its refractory period in the brain of rats and monkeys. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2015.00072","journal-title":"Front Cell Neurosci"},{"key":"3627_CR8","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/nrn1197","volume":"4","author":"D Berg","year":"2003","unstructured":"Berg D, Holzmann C, Riess O (2003) 14-3-3 proteins in the nervous system. Nat Rev Neurosci 4:752\u2013762","journal-title":"Nat Rev Neurosci"},{"key":"3627_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/tpj.2008.15","volume":"9","author":"RH Bonow","year":"2009","unstructured":"Bonow RH, Aid S, Zhang Y, Becker KG, Bosetti F (2009) The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice. Pharmacogenom J 9:116\u2013126","journal-title":"Pharmacogenom J"},{"key":"3627_CR10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1586\/14789450.2016.1149470","volume":"13","author":"DA Butterfield","year":"2016","unstructured":"Butterfield DA, Palmieri EM, Castegna A (2016) Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins. Expert Rev Proteom 13:259\u2013274","journal-title":"Expert Rev Proteom"},{"key":"3627_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17999-3","author":"E Castillo","year":"2017","unstructured":"Castillo E, Leon J, Mazzei G et al (2017) Comparative profiling of cortical gene expression in Alzheimer\u2019s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep-UK. https:\/\/doi.org\/10.1038\/s41598-017-17999-3","journal-title":"Sci Rep-UK"},{"key":"3627_CR12","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0306-4522(00)00322-5","volume":"101","author":"RKW Chan","year":"2000","unstructured":"Chan RKW, Vale WW, Sawchenko PE (2000) Paradoxical activational effects of a corticotropin-releasing factor-binding protein \u201cligand inhibitor\u201d in rat brain. Neuroscience 101:115\u2013129","journal-title":"Neuroscience"},{"key":"3627_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s40478-022-01494-6","volume":"10","author":"S Chen","year":"2022","unstructured":"Chen S, Chang Y, Li L et al (2022) Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer\u2019s disease. Acta Neuropathol Commun 10:188","journal-title":"Acta Neuropathol Commun"},{"key":"3627_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s12017-013-8230-5","volume":"15","author":"LM Collins","year":"2013","unstructured":"Collins LM, O\u2019Keeffe GW, Long-Smith CM et al (2013) Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons. Neuromol Med 15:435\u2013446","journal-title":"Neuromol Med"},{"key":"3627_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00318","author":"B Cornell","year":"2017","unstructured":"Cornell B, Toyo-Oka K (2017) 14\u20133-3 proteins in brain development: neurogenesis, neuronal migration and neuromorphogenesis. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2017.00318","journal-title":"Front Mol Neurosci"},{"key":"3627_CR16","doi-asserted-by":"publisher","first-page":"217.e1","DOI":"10.1016\/j.neurobiolaging.2015.10.036","volume":"38","author":"J Coxhead","year":"2016","unstructured":"Coxhead J, Kurzawa-Akanbi M, Hussain R, Pyle A, Chinnery P, Hudson G (2016) Somatic mtDNA variation is an important component of Parkinson\u2019s disease. Neurobiol Aging 38:217.e1-217.e6","journal-title":"Neurobiol Aging"},{"key":"3627_CR17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3233\/JAD-170799","volume":"65","author":"YE Cruz-Rivera","year":"2018","unstructured":"Cruz-Rivera YE, Perez-Morales J, Santiago YM et al (2018) A selection of important genes and their correlated behavior in Alzheimer\u2019s disease. J Alzheimers Dis 65:193\u2013205","journal-title":"J Alzheimers Dis"},{"key":"3627_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00329","author":"A Dautant","year":"2018","unstructured":"Dautant A, Meier T, Hahn A, Tribouillard-Tanvier D, di Rago JP, Kucharczyk R (2018) ATP synthase diseases of mitochondrial genetic origin. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2018.00329","journal-title":"Front Physiol"},{"key":"3627_CR19","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.freeradbiomed.2009.11.001","volume":"48","author":"CW Davis","year":"2010","unstructured":"Davis CW, Hawkins BJ, Ramasamy S et al (2010) Nitration of the mitochondrial complex I subunit NDUFB8 elicits RIP1- and RIP3-mediated necrosis. Free Radic Biol Med 48:306\u2013317","journal-title":"Free Radic Biol Med"},{"key":"3627_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66901-1","author":"F Demars","year":"2020","unstructured":"Demars F, Kebir O, Marzo A et al (2020) Dysregulation of peripheral expression of the YWHA genes during conversion to psychosis. Sci Rep UK. https:\/\/doi.org\/10.1038\/s41598-020-66901-1","journal-title":"Sci Rep UK"},{"key":"3627_CR21","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.2174\/092986707780597961","volume":"14","author":"ST Dheen","year":"2007","unstructured":"Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189\u20131197","journal-title":"Curr Med Chem"},{"key":"3627_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02324-6","author":"MK Elder","year":"2021","unstructured":"Elder MK, Erdjument-Bromage H, Oliveira MM, Mamcarz M, Neubert TA, Klann E (2021) Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer\u2019s disease mouse model. Commun Biol. https:\/\/doi.org\/10.1038\/s42003-021-02324-6","journal-title":"Commun Biol"},{"key":"3627_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-021-01208-4","author":"HT Evans","year":"2021","unstructured":"Evans HT, Taylor D, Kneynsberg A, Bodea LG, Gotz J (2021) Altered ribosomal function and protein synthesis caused by tau. Acta Neuropathol Commun. https:\/\/doi.org\/10.1186\/s40478-021-01208-4","journal-title":"Acta Neuropathol Commun"},{"key":"3627_CR24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jns.2012.05.030","volume":"322","author":"A Federico","year":"2012","unstructured":"Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E (2012) Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci 322:254\u2013262","journal-title":"J Neurol Sci"},{"key":"3627_CR25","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/toxsci\/kfad077","volume":"194","author":"A Fergany","year":"2023","unstructured":"Fergany A, Zong C, Ekuban FA et al (2023) Deletion of IL-1beta exacerbates acrylamide-induced neurotoxicity in mice. Toxicol Sci 194:246\u2013256","journal-title":"Toxicol Sci"},{"key":"3627_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-020-00772","author":"T Flati","year":"2020","unstructured":"Flati T, Gioiosa S, Chillemi G et al (2020) A gene expression atlas for different kinds of stress in the mouse brain. Sci Data. https:\/\/doi.org\/10.1038\/s41597-020-00772","journal-title":"Sci Data"},{"key":"3627_CR27","first-page":"15","volume":"6","author":"P Garcia-Esparcia","year":"2017","unstructured":"Garcia-Esparcia P, Sideris-Lampretsas G, Hernandez-Ortega K et al (2017) Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model. Am J Neurodegener Dis 6:15\u201325","journal-title":"Am J Neurodegener Dis"},{"key":"3627_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00401-018-1934-8","volume":"137","author":"M Gautam","year":"2019","unstructured":"Gautam M, Jara JH, Kocak N et al (2019) Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology. Acta Neuropathol 137:47\u201369","journal-title":"Acta Neuropathol"},{"key":"3627_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00043","author":"G Giachin","year":"2016","unstructured":"Giachin G, Bouverot R, Acajjaoui S, Pantalone S, Soler-Lopez M (2016) Dynamics of human mitochondrial complex I assembly: implications for neurodegenerative diseases. Front Mol Biosci. https:\/\/doi.org\/10.3389\/fmolb.2016.00043","journal-title":"Front Mol Biosci"},{"key":"3627_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.brainresbull.2011.02.001","volume":"85","author":"JD Hawk","year":"2011","unstructured":"Hawk JD, Abel T (2011) The role of NR4A transcription factors in memory formation. Brain Res Bull 85:21\u201329","journal-title":"Brain Res Bull"},{"key":"3627_CR31","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1016\/j.cub.2017.10.002","volume":"27","author":"JL Henty-Ridilla","year":"2017","unstructured":"Henty-Ridilla JL, Juanes MA, Goode BL (2017) Profilin directly promotes microtubule growth through residues mutated in amyotrophic lateral sclerosis. Curr Biol 27:3535-3543.e4","journal-title":"Curr Biol"},{"key":"3627_CR32","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1093\/cercor\/bht101","volume":"24","author":"M Hokama","year":"2014","unstructured":"Hokama M, Oka S, Leon J et al (2014) Altered expression of diabetes-related genes in Alzheimer\u2019s disease brains: the Hisayama study. Cereb Cortex 24:2476\u20132488","journal-title":"Cereb Cortex"},{"key":"3627_CR33","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0166-2236(95)80029-2","volume":"18","author":"SJ Hopkins","year":"1995","unstructured":"Hopkins SJ, Rothwell NJ (1995) Cytokines and the nervous system. I: expression and recognition. Trends Neurosci 18:83\u201388","journal-title":"Trends Neurosci"},{"issue":"9","key":"3627_CR96","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","volume":"187","author":"C Horai","year":"1998","unstructured":"Horai R, Asano M, Sudo K, Kanuka H, Suzuki M, Nishihara M, Takahashi M, Iwakuraet Y (1998) Production of mice deficient in genes for interleukin (IL)-1\u03b1 IL-1\u03b2 IL-1\u03b1\/\u03b2 and IL-1 receptor antagonist shows that IL-1\u03b2 Is Crucial in Turpentine-induced Fever development and glucocorticoid secretion.\u00a0 J Exp Med 187(9):1463\u20131475. https:\/\/doi.org\/10.1084\/jem.187.9.1463","journal-title":"J Exp Med"},{"key":"3627_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1539\/joh.44.1","volume":"44","author":"G Ichihara","year":"2002","unstructured":"Ichihara G, Miller JK, Ziolkokwska A, Itohara S, Takeuchi Y (2002) Neurological disorders in three workers exposed to 1-bromopropane. J Occup Health 44:1\u20137","journal-title":"J Occup Health"},{"key":"3627_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0014-5793(87)81194-8","volume":"219","author":"T Ichimura","year":"1987","unstructured":"Ichimura T, Isobe T, Okuyama T, Yamauchi T, Fujisawa H (1987) Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+, calmodulin-dependent protein kinase-II. FEBS Lett 219:79\u201382","journal-title":"FEBS Lett"},{"key":"3627_CR36","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1136\/jnnp.38.6.581","volume":"38","author":"H Igisu","year":"1975","unstructured":"Igisu H, Goto I, Kawamura Y, Kato M, Izumi K, Kuroiwa O (1975) Acrylamide encephaloneuropathy due to well water-pollution. J Neurol Neurosurg Psychiatry 38:581\u2013584","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3627_CR37","doi-asserted-by":"publisher","first-page":"459","DOI":"10.5483\/BMBRep.2016.49.9.094","volume":"49","author":"E Im","year":"2016","unstructured":"Im E, Chung KC (2016) Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases. BMB Rep 49:459\u2013473","journal-title":"BMB Rep"},{"key":"3627_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/glia.20109","volume":"49","author":"GR John","year":"2005","unstructured":"John GR, Lee SC, Song X, Rivieccio M, Brosnan CF (2005) IL-1-regulated responses in astrocytes: relevance to injury and recovery. Glia 49:161\u2013176","journal-title":"Glia"},{"key":"3627_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27\u201330","journal-title":"Nucleic Acids Res"},{"key":"3627_CR40","doi-asserted-by":"publisher","first-page":"5539","DOI":"10.1523\/JNEUROSCI.4731-13.2014","volume":"34","author":"HS Kwon","year":"2014","unstructured":"Kwon HS, Nakaya N, Abu-Asab M, Kim HS, Tomarev SI (2014) Myocilin is involved in NgR1\/Lingo-1-mediated oligodendrocyte differentiation and myelination of the optic nerve. J Neurosci 34:5539\u20135551","journal-title":"J Neurosci"},{"key":"3627_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinform. https:\/\/doi.org\/10.1186\/1471-2105-9-","journal-title":"BMC Bioinform"},{"key":"3627_CR42","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/ahg.12064","volume":"78","author":"O Levran","year":"2014","unstructured":"Levran O, Randesi M, Li Y et al (2014) Drug addiction and stress-response genetic variability: association study in African Americans. Ann Hum Genet 78:290\u2013298","journal-title":"Ann Hum Genet"},{"key":"3627_CR43","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2217\/pgs-2017-0179","volume":"19","author":"O Levran","year":"2018","unstructured":"Levran O, Peles E, Randesi M et al (2018) Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Pharmacogenomics 19:333\u2013341","journal-title":"Pharmacogenomics"},{"key":"3627_CR44","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/437483","author":"Y Li","year":"2014","unstructured":"Li Y, Tan MS, Jiang T, Tan L (2014) Microglia in Alzheimer\u2019s disease. Biomed Res Int. https:\/\/doi.org\/10.1155\/2014\/437483","journal-title":"Biomed Res Int"},{"key":"3627_CR45","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4169575","author":"X Li","year":"2018","unstructured":"Li X, Liu JJ, Chen B, Fan LH (2018) A positive feedback loop of profilin-1 and RhoA\/ROCK1 promotes endothelial dysfunction and oxidative stress. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2018\/4169575","journal-title":"Oxid Med Cell Longev"},{"key":"3627_CR46","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787\u2013795","journal-title":"Nature"},{"key":"3627_CR47","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.neuro.2004.01.004","volume":"25","author":"RM LoPachin","year":"2004","unstructured":"LoPachin RM (2004) The changing view of acrylamide neurotoxicity. Neurotoxicology 25:617\u2013630","journal-title":"Neurotoxicology"},{"key":"3627_CR48","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1289\/ehp.1205432","volume":"120","author":"RM LoPachin","year":"2012","unstructured":"LoPachin RM, Gavin T (2012) Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry. Environ Health Perspect 120:1650\u20131657","journal-title":"Environ Health Perspect"},{"key":"3627_CR49","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0041-008X(02)00072-8","volume":"188","author":"RM LoPachin","year":"2003","unstructured":"LoPachin RM, Balaban CD, Ross JF (2003) Acrylamide axonopathy revisited. Toxicol Appl Pharm 188:135\u2013153","journal-title":"Toxicol Appl Pharm"},{"key":"3627_CR50","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.4049\/jimmunol.1102487","volume":"190","author":"J Lu","year":"2013","unstructured":"Lu J, Wu X, Hong M, Tobias P, Han J (2013) A potential suppressive effect of natural antisense IL-1beta RNA on lipopolysaccharide-induced IL-1beta expression. J Immunol 190:6570\u20136578","journal-title":"J Immunol"},{"key":"3627_CR51","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1111\/cas.13711","volume":"109","author":"YC Lu","year":"2018","unstructured":"Lu YC, Wang Y, Xu H, Shi C, Jin FY, Li W (2018) Profilin 1 induces drug resistance through Beclin1 complex-mediated autophagy in multiple myeloma. Cancer Sci 109:2706\u20132716","journal-title":"Cancer Sci"},{"key":"3627_CR52","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1002\/jnr.24607","volume":"98","author":"E Lu","year":"2020","unstructured":"Lu E, Wang Q, Li S et al (2020) Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA\/ROCK pathway. J Neurosci Res 98:1198\u20131212","journal-title":"J Neurosci Res"},{"key":"3627_CR53","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","volume":"11","author":"R Luthi-Carter","year":"2002","unstructured":"Luthi-Carter R, Hanson SA, Strand AD et al (2002) Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain. Hum Mol Genet 11:1911\u20131926","journal-title":"Hum Mol Genet"},{"key":"3627_CR54","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mito.2005.01.002","volume":"5","author":"G Manfredi","year":"2005","unstructured":"Manfredi G, Xu ZS (2005) Mitochondrial dysfunction and its role in motor neuron degeneration in ALS. Mitochondrion 5:77\u201387","journal-title":"Mitochondrion"},{"key":"3627_CR55","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.inffus.2016.11.005","volume":"36","author":"M Martinez-Ballesteros","year":"2017","unstructured":"Martinez-Ballesteros M, Garcia-Heredia JM, Nepomuceno-Chamorro IA, Riquelme-Santos JC (2017) Machine learning techniques to discover genes with potential prognosis role in Alzheimer\u2019s disease using different biological sources. Inform Fusion 36:114\u2013129","journal-title":"Inform Fusion"},{"key":"3627_CR56","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.ijdevneu.2014.09.006","volume":"38","author":"JS Medel-Matus","year":"2014","unstructured":"Medel-Matus JS, Alvarez-Croda DM, Martinez-Quiroz J, Beltran-Parrazal L, Morgado-Valle C, Lopez-Meraz ML (2014) IL-1beta increases necrotic neuronal cell death in the developing rat hippocampus after status epilepticus by activating type I IL-1 receptor (IL-1RI). Int J Dev Neurosci 38:232\u2013240","journal-title":"Int J Dev Neurosci"},{"key":"3627_CR57","doi-asserted-by":"publisher","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","volume":"45","author":"H Mi","year":"2017","unstructured":"Mi H, Huang X, Muruganujan A et al (2017) PANTHER version 11: expanded annotation data from gene ontology and reactome pathways, and data analysis tool enhancements. Nucleic Acids Res 45:D183\u2013D189","journal-title":"Nucleic Acids Res"},{"key":"3627_CR58","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/251204","volume":"2015","author":"BS Mietto","year":"2015","unstructured":"Mietto BS, Mostacada K, Martinez AM (2015) Neurotrauma and inflammation: CNS and PNS responses. Mediat Inflamm 2015:251204","journal-title":"Mediat Inflamm"},{"key":"3627_CR59","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/419448a","volume":"419","author":"DS Mottram","year":"2002","unstructured":"Mottram DS, Wedzicha BL, Dodson AT (2002) Acrylamide is formed in the Maillard reaction. Nature 419:448\u2013449","journal-title":"Nature"},{"key":"3627_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00018","author":"KN Murray","year":"2015","unstructured":"Murray KN, Parry-Jones AR, Allan SM (2015) Interleukin-1 and acute brain injury. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2015.00018","journal-title":"Front Cell Neurosci"},{"key":"3627_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33964-0","author":"T Nakaya","year":"2018","unstructured":"Nakaya T, Maragkakis M (2018) Amyotrophic lateral sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity. Sci Rep UK. https:\/\/doi.org\/10.1038\/s41598-018-33964-0","journal-title":"Sci Rep UK"},{"key":"3627_CR62","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1176\/appi.ajp.2017.17020172","volume":"175","author":"CP O'Connell","year":"2018","unstructured":"O\u2019Connell CP, Goldstein-Piekarski AN, Nemeroff CB et al (2018) Antidepressant outcomes predicted by genetic variation in corticotropin-releasing hormone binding protein. Am J Psychiatry 175:251\u2013261","journal-title":"Am J Psychiatry"},{"key":"3627_CR63","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nrg3594","volume":"14","author":"V Pelechano","year":"2013","unstructured":"Pelechano V, Steinmetz LM (2013) Gene regulation by antisense transcription. Nat Rev Genet 14:880\u2013893","journal-title":"Nat Rev Genet"},{"key":"3627_CR64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081999","author":"R Perez-Sen","year":"2019","unstructured":"Perez-Sen R, Queipo MJ, Gil-Redondo JC et al (2019) Dual-specificity phosphatase regulation in neurons and glial cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20081999","journal-title":"Int J Mol Sci"},{"key":"3627_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.006.2007","author":"R Poirier","year":"2007","unstructured":"Poirier R, Cheval H, Mailhes C, Charnay P, Davis S, Laroche S (2007) Paradoxical role of an Egr transcription factor family member, Egr2\/Krox20, in learning and memory. Front Behav Neurosci. https:\/\/doi.org\/10.3389\/neuro.08.006.2007","journal-title":"Front Behav Neurosci"},{"key":"3627_CR66","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1007\/s13311-015-0385-3","volume":"12","author":"RM Ransohoff","year":"2015","unstructured":"Ransohoff RM, Schafer D, Vincent A, Blachere NE, Bar-Or A (2015) Neuroinflammation: ways in which the immune system affects the brain. Neurotherapeutics 12:896\u2013909","journal-title":"Neurotherapeutics"},{"key":"3627_CR67","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.bbabio.2016.02.012","volume":"1857","author":"RJ Rodenburg","year":"2016","unstructured":"Rodenburg RJ (2016) Mitochondrial complex I-linked disease. BBA Bioenerget 1857:938\u2013945","journal-title":"BBA Bioenerget"},{"key":"3627_CR68","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fncel.2020.00093","volume":"14","author":"A Sancho-Balsells","year":"2020","unstructured":"Sancho-Balsells A, Brito V, Fernandez B et al (2020) Lack of helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1. Front Cell Neurosci 14:93","journal-title":"Front Cell Neurosci"},{"key":"3627_CR69","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/S0140-6736(11)61305-6","volume":"379","author":"AHV Schapira","year":"2012","unstructured":"Schapira AHV (2012) Mitochondrial diseases. Lancet 379:1825\u20131834","journal-title":"Lancet"},{"key":"3627_CR70","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.neuron.2011.06.003","volume":"70","author":"EA Schon","year":"2011","unstructured":"Schon EA, Przedborski S (2011) Mitochondria: the next (neurode)generation. Neuron 70:1033\u20131053","journal-title":"Neuron"},{"key":"3627_CR71","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/S0005-2728(02)00185-8","volume":"1553","author":"AE Senior","year":"2002","unstructured":"Senior AE, Nadanaciva S, Weber J (2002) The molecular mechanism of ATP synthesis by F1F0-ATP synthase. BBA Bioenerget 1553:188\u2013211","journal-title":"BBA Bioenerget"},{"key":"3627_CR72","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122163","author":"S Shichino","year":"2019","unstructured":"Shichino S, Ueha S, Hashimoto S et al (2019) Transcriptome network analysis identifies protective role of the LXR\/SREBP-1c axis in murine pulmonary fibrosis. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.122163","journal-title":"JCI Insight"},{"key":"3627_CR73","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1590\/0004-282X20150083","volume":"73","author":"B Silva","year":"2015","unstructured":"Silva B, Sousa L, Miranda A et al (2015) Memory deficit associated with increased brain proinflammatory cytokine levels and neurodegeneration in acute ischemic stroke. Arq Neuropsiquiatr 73:655\u2013659","journal-title":"Arq Neuropsiquiatr"},{"key":"3627_CR74","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.3390\/molecules24081583","volume":"24","author":"A Singh","year":"2019","unstructured":"Singh A, Kukreti R, Saso L, Kukreti S (2019) Oxidative stress: a key modulator in neurodegenerative diseases. Molecules 24:1583","journal-title":"Molecules"},{"key":"3627_CR75","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.conb.2014.03.005","volume":"27","author":"SA Sloan","year":"2014","unstructured":"Sloan SA, Barres BA (2014) Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders. Curr Opin Neurobiol 27:75\u201381","journal-title":"Curr Opin Neurobiol"},{"key":"3627_CR76","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1515\/REVEH.1991.9.4.215","volume":"9","author":"E Smith","year":"1991","unstructured":"Smith E, Oehme F (1991) Acrylamide and polyacrylamide: a review of production, use, environmental fate and neurotoxicity. Rev Environ Health 9:215\u2013228","journal-title":"Rev Environ Health"},{"key":"3627_CR77","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/419449a","volume":"419","author":"RH Stadler","year":"2002","unstructured":"Stadler RH, Blank I, Varga N et al (2002) Acrylamide from Maillard reaction products. Nature 419:449\u2013450","journal-title":"Nature"},{"key":"3627_CR78","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/glia.440010502","volume":"1","author":"WJ Streit","year":"1988","unstructured":"Streit WJ, Graeber MB, Kreutzberg GW (1988) Functional plasticity of microglia\u2014a review. Glia 1:301\u2013307","journal-title":"Glia"},{"key":"3627_CR79","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14","author":"JQ Sun","year":"2013","unstructured":"Sun JQ, Nishiyama T, Shimizu K, Kadota K (2013) TCC: an R package for comparing tag count data with robust normalization strategies. BMC Bioinform. https:\/\/doi.org\/10.1186\/1471-2105-14","journal-title":"BMC Bioinform"},{"key":"3627_CR80","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12974-021-02135-w","volume":"18","author":"K Suzuki","year":"2021","unstructured":"Suzuki K, Shinohara M, Uno Y et al (2021) Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion. J Neuroinflammation 18:86","journal-title":"J Neuroinflammation"},{"key":"3627_CR81","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11499","author":"G Szalay","year":"2016","unstructured":"Szalay G, Martinecz B, Lenart N et al (2016) Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms11499","journal-title":"Nat Commun"},{"key":"3627_CR82","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1186\/s12859-015-0794-7","volume":"16","author":"M Tang","year":"2015","unstructured":"Tang M, Sun J, Shimizu K, Kadota K (2015) Evaluation of methods for differential expression analysis on multi-group RNA-seq count data. BMC Bioinform 16:361","journal-title":"BMC Bioinform"},{"key":"3627_CR83","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1523\/JNEUROSCI.4965-11.2013","volume":"33","author":"DM Taylor","year":"2013","unstructured":"Taylor DM, Moser R, Regulier E et al (2013) MAP kinase phosphatase 1 (MKP-1\/DUSP1) is neuroprotective in Huntington\u2019s disease via additive effects of JNK and p38 inhibition. J Neurosci 33:2313\u20132325","journal-title":"J Neurosci"},{"key":"3627_CR84","unstructured":"The Human Proteinatlas (2023) https:\/\/www.proteinatlas.org\/"},{"key":"3627_CR85","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mito.2010.08.009","volume":"11","author":"L Tillement","year":"2011","unstructured":"Tillement L, Lecanu L, Papadopoulos V (2011) Alzheimer\u2019s disease: effects of beta-amyloid on mitochondria. Mitochondrion 11:13\u201321","journal-title":"Mitochondrion"},{"key":"3627_CR86","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/ng1169","volume":"34","author":"K Toyo-oka","year":"2003","unstructured":"Toyo-oka K, Shionoya A, Gambello MJ et al (2003) 14-3-3 epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller\u2013Dieker syndrome. Nat Genet 34:274\u2013285","journal-title":"Nat Genet"},{"key":"3627_CR87","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0896-6273(03)00461-6","volume":"39","author":"MA Ungless","year":"2003","unstructured":"Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A (2003) Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron 39:401\u2013407","journal-title":"Neuron"},{"key":"3627_CR88","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nrd4018","volume":"12","author":"C Wahlestedt","year":"2013","unstructured":"Wahlestedt C (2013) Targeting long non-coding RNA to therapeutically upregulate gene expression. Nat Rev Drug Discov 12:433\u2013446","journal-title":"Nat Rev Drug Discov"},{"key":"3627_CR89","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00213-007-0782-3","volume":"193","author":"B Wang","year":"2007","unstructured":"Wang B, You ZB, Rice KC, Wise RA (2007) Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology 193:283\u2013294","journal-title":"Psychopharmacology"},{"key":"3627_CR90","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s000180050296","volume":"55","author":"B Weiss","year":"1999","unstructured":"Weiss B, Davidkova G, Zhou LW (1999) Antisense RNA gene therapy for studying and modulating biological processes. Cell Mol Life Sci 55:334\u2013358","journal-title":"Cell Mol Life Sci"},{"key":"3627_CR91","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1073\/pnas.94.2.514","volume":"94","author":"FM Yakes","year":"1997","unstructured":"Yakes FM, VanHouten B (1997) Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci USA 94:514\u2013519","journal-title":"Proc Natl Acad Sci USA"},{"key":"3627_CR92","first-page":"1","volume":"2017","author":"DF Yang","year":"2017","unstructured":"Yang DF, Wang Y, Jiang MN et al (2017) Downregulation of profilin-1 expression attenuates cardiomyocytes hypertrophy and apoptosis induced by advanced glycation end products in H9c2 cells. Biomed Res Int 2017:1\u201311","journal-title":"Biomed Res Int"},{"key":"3627_CR93","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1080\/10408390600920070","volume":"47","author":"Y Zhang","year":"2007","unstructured":"Zhang Y, Zhang Y (2007) Formation and reduction of acrylamide in Maillard reaction: a review based on the current state of knowledge. Crit Rev Food Sci Nutr 47:521\u2013542","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3627_CR94","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2018.32.1_supplement.628.4","author":"JR Zhao","year":"2018","unstructured":"Zhao JR, Wade B, Ma J, Hart CM, Sutliff R (2018) Differential ubiquitination of profilin-1 in hypoxia-induced pulmonary hypertension. FASEB J. https:\/\/doi.org\/10.1096\/fasebj.2018.32.1_supplement.628.4","journal-title":"FASEB J"},{"key":"3627_CR95","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s00204-019-02471-0","volume":"93","author":"C Zong","year":"2019","unstructured":"Zong C, Hasegawa R et al (2019) Role of microglial activation and neuroinflammation in neurotoxicity of acrylamide in vivo and in vitro. Arch Toxicol 93:2007\u20132019","journal-title":"Arch Toxicol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-023-03627-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-023-03627-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-023-03627-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T02:03:06Z","timestamp":1704247386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-023-03627-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["3627"],"URL":"https:\/\/doi.org\/10.1007\/s00204-023-03627-9","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]},"assertion":[{"value":"9 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}