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All the patients provided written informed consent before sampling and for the use of their clinical and biological data. This study was approved by the Ethics Committee of Capital Medical University and Fuxing Hospital affiliated to Capital Medical University (2018SY04). All clinical investigations were conducted according to the Declaration of Helsinki principles, and informed consent was obtained from all study participants. Animal experiments were conducted in accordance with the National Institutes of Health guidelines and were approved by the Institutional Animal Care and Use Committee at Capital Medical University (AEEI-2021-163).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}