{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:12:00Z","timestamp":1793495520674,"version":"4.5.0"},"reference-count":308,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003194","name":"Agent\u00fara Ministerstva \u0160kolstva, Vedy, V\u00fdskumu a \u0160portu SR","doi-asserted-by":"publisher","award":["1\/0542\/24"],"award-info":[{"award-number":["1\/0542\/24"]}],"id":[{"id":"10.13039\/501100003194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["RSP2024R35"],"award-info":[{"award-number":["RSP2024R35"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["UHHK"],"award-info":[{"award-number":["UHHK"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00179906"],"award-info":[{"award-number":["00179906"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018512","name":"Univerzita Hradec Kr\u00e1lov\u00e9","doi-asserted-by":"publisher","award":["Excelence PrF UHK 2208\/2023-2024"],"award-info":[{"award-number":["Excelence PrF UHK 2208\/2023-2024"]}],"id":[{"id":"10.13039\/100018512","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Slovak Technical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer\u2019s and Parkinson\u2019s diseases), and other disorders. To counteract the harmful effects of ROS, organisms have evolved a complex, three-line antioxidant defense system. The first-line defense mechanism is the most efficient and involves antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). This line of defense plays an irreplaceable role in the dismutation of superoxide radicals (O\n 2<\/jats:sub>\n \u00b7\u2212<\/jats:sup>\n ) and hydrogen peroxide (H\n 2<\/jats:sub>\n O\n 2<\/jats:sub>\n ). The removal of superoxide radicals by SOD prevents the formation of the much more damaging peroxynitrite ONOO\n \u2212<\/jats:sup>\n (O\n 2<\/jats:sub>\n \u00b7\u2212<\/jats:sup>\n \u2009+\u2009NO\n \u00b7<\/jats:sup>\n \u2009\u2192\u2009ONOO\n \u2212<\/jats:sup>\n ) and maintains the physiologically relevant level of nitric oxide (NO\n \u00b7<\/jats:sup>\n ), an important molecule in neurotransmission, inflammation, and vasodilation. The second-line antioxidant defense pathway involves exogenous diet-derived small-molecule antioxidants. The third-line antioxidant defense is ensured by the repair or removal of oxidized proteins and other biomolecules by a variety of enzyme systems. This review briefly discusses the endogenous (mitochondria, NADPH, xanthine oxidase (XO), Fenton reaction) and exogenous (e.g., smoking, radiation, drugs, pollution) sources of ROS (superoxide radical, hydrogen peroxide, hydroxyl radical, peroxyl radical, hypochlorous acid, peroxynitrite). Attention has been given to the first-line antioxidant defense system provided by SOD, CAT, and GPx. The chemical and molecular mechanisms of antioxidant enzymes, enzyme-related diseases (cancer, cardiovascular, lung, metabolic, and neurological diseases), and the role of enzymes (e.g., GPx4) in cellular processes such as ferroptosis are discussed. Potential therapeutic applications of enzyme mimics and recent progress in metal-based (copper, iron, cobalt, molybdenum, cerium) and nonmetal (carbon)-based nanomaterials with enzyme-like activities (nanozymes) are also discussed. Moreover, attention has been given to the mechanisms of action of low-molecular-weight antioxidants (vitamin C (ascorbate), vitamin E (alpha-tocopherol), carotenoids\u00a0(e.g., \u03b2-carotene, lycopene, lutein), flavonoids\u00a0(e.g.,\u00a0quercetin, anthocyanins, epicatechin), and glutathione (GSH)), the activation of transcription factors such as Nrf2, and the protection against chronic diseases. Given that there is a discrepancy between preclinical and clinical studies, approaches that may result in greater pharmacological and clinical success of low-molecular-weight antioxidant therapies are also subject to discussion.\n <\/jats:p>","DOI":"10.1007\/s00204-024-03696-4","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T06:03:48Z","timestamp":1710396228000},"page":"1323-1367","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1458,"title":["Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants"],"prefix":"10.1007","volume":"98","author":[{"given":"Klaudia","family":"Jomova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suliman Y.","family":"Alomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh H.","family":"Alwasel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenie","family":"Nepovimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-0267","authenticated-orcid":false,"given":"Marian","family":"Valko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"3696_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.bbapap.2009.11.005","volume":"2","author":"IA Abreu","year":"1804","unstructured":"Abreu IA (1804) Cabelli DE (2010) Superoxide dismutases-a review of the metal-associated mechanistic variations. Biochim Biophys Acta 2:263\u2013274. https:\/\/doi.org\/10.1016\/j.bbapap.2009.11.005","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"3696_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2119\/molmed.2011.00339","volume":"18","author":"MN Ahmed","year":"2012","unstructured":"Ahmed MN, Zhang Y, Codipilly C, Zaghloul N, Patel D, Wolin M, Miller EJ (2012) Extracellular superoxide dismutase overexpression can reverse the course of hypoxia-induced pulmonary hypertension. Mol Med 18(1):38\u201346. https:\/\/doi.org\/10.2119\/molmed.2011.00339","journal-title":"Mol Med"},{"issue":"8","key":"3696_CR3","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.freeradbiomed.2004.07.002","volume":"37","author":"SS Ali","year":"2004","unstructured":"Ali SS, Hardt JI, Quick KL, Kim-Han JS, Erlanger BF, Huang TT, Epstein CJ, Dugan LL (2004) A biologically effective fullerene (C60) derivative with superoxide dismutase mimic properties. Free Radic Biol Med 37(8):1191\u20131202. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.07.002","journal-title":"Free Radic Biol Med"},{"key":"3696_CR4","doi-asserted-by":"publisher","unstructured":"An BC, Jung NK, Park CY, Oh IJ, Choi YD, Park JI, Lee SW (2016) Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells. Mol Cells 39(8):631\u2013638. https:\/\/doi.org\/10.14348\/molcells.2016.0164","DOI":"10.14348\/molcells.2016.0164"},{"key":"3696_CR5","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.biopha.2014.10.011","volume":"68","author":"JC Andrade","year":"2014","unstructured":"Andrade JC, Morais-Braga MF, Guedes GM et al (2014) Enhancement of the antibiotic activity of aminoglycosides by alpha-tocopherol and other cholesterol derivates. Biomed Pharmacother 68:1065\u20131069. https:\/\/doi.org\/10.1016\/j.biopha.2014.10.011","journal-title":"Biomed Pharmacother"},{"issue":"18","key":"3696_CR6","doi-asserted-by":"publisher","first-page":"10735","DOI":"10.3390\/ijms231810735","volume":"23","author":"CMC Andr\u00e9s","year":"2022","unstructured":"Andr\u00e9s CMC, P\u00e9rez de la Lastra JM, Juan CA, Plou FJ, P\u00e9rez-Lebe\u00f1a E (2022) Hypochlorous acid chemistry in mammalian cells\u2014influence on infection and role in various pathologies. Int J Mol Sci 23(18):10735. https:\/\/doi.org\/10.3390\/ijms231810735","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3696_CR7","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/hep.26160","volume":"57","author":"S Anth\u00e9rieu","year":"2013","unstructured":"Anth\u00e9rieu S, Bachour-El Azzi P, Dumont J et al (2013) Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology 57(4):1518\u20131529. https:\/\/doi.org\/10.1002\/hep.26160","journal-title":"Hepatology"},{"issue":"4","key":"3696_CR8","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/oxygen2040030","volume":"2","author":"AK Aranda-Rivera","year":"2022","unstructured":"Aranda-Rivera AK, Cruz-Gregorio A, Arancibia-Hern\u00e1ndez YL, Hern\u00e1ndez-Cruz EY, Pedraza-Chaverri J (2022) RONS and Oxidative Stress: An Overview of Basic Concepts. Oxygen 2(4):437\u2013478. https:\/\/doi.org\/10.3390\/oxygen2040030","journal-title":"Oxygen"},{"issue":"2","key":"3696_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172803","volume":"12","author":"MC Asensio-L\u00f3pez","year":"2017","unstructured":"Asensio-L\u00f3pez MC, Soler F, Pascual-Figal D, Fern\u00e1ndez-Belda F, Lax A (2017) Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes. PLoS ONE 12(2):e0172803. https:\/\/doi.org\/10.1371\/journal.pone.0172803","journal-title":"PLoS ONE"},{"issue":"2","key":"3696_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3945\/ajcn.112.034165","volume":"96","author":"D Aune","year":"2012","unstructured":"Aune D, Chan DS, Vieira AR, Navarro Rosenblatt DA, Vieira R, Greenwood DC, Norat T (2012) Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 96(2):356\u2013373. https:\/\/doi.org\/10.3945\/ajcn.112.034165","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"3696_CR11","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3390\/antiox11081431","volume":"11","author":"A Azzi","year":"2022","unstructured":"Azzi A (2022) Oxidative stress: what is it? Can it be measured? where is it located? can it be good or bad? can it be prevented? can it be cured? Antioxidants (basel) 11(8):1431. https:\/\/doi.org\/10.3390\/antiox11081431","journal-title":"Antioxidants (basel)"},{"key":"3696_CR12","doi-asserted-by":"publisher","unstructured":"Babior BM, Kipnes RS, Curnutte JT (1973) Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52(3):741\u2013744. https:\/\/doi.org\/10.1172\/JCI107236","DOI":"10.1172\/JCI107236"},{"issue":"11","key":"3696_CR13","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1016\/j.jnutbio.2013.06.003","volume":"24","author":"PV Babu","year":"2013","unstructured":"Babu PV, Liu D, Gilbert ER (2013) Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem 24(11):1777\u20131789. https:\/\/doi.org\/10.1016\/j.jnutbio.2013.06.003","journal-title":"J Nutr Biochem"},{"issue":"10","key":"3696_CR14","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1002\/anie.200353128","volume":"43","author":"TG Back","year":"2004","unstructured":"Back TG, Moussa Z, Parvez M (2004) The exceptional glutathione peroxidase-like activity of di(3-hydroxypropyl) selenide and the unexpected role of a novel spirodioxaselenanonane intermediate in the catalytic cycle. Angew Chem Int Ed Engl 43(10):1268\u20131270. https:\/\/doi.org\/10.1002\/anie.200353128","journal-title":"Angew Chem Int Ed Engl"},{"key":"3696_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.fct.2004.01.001","volume":"42","author":"RR Baker","year":"2004","unstructured":"Baker RR, Massey ED, Smith G (2004) An overview of the effects of tobacco ingredients on smoke chemistry and toxicity. Food Chem Toxicol 42:53\u201383. https:\/\/doi.org\/10.1016\/j.fct.2004.01.001","journal-title":"Food Chem Toxicol"},{"key":"3696_CR16","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.redox.2017.09.009","volume":"14","author":"S Bartesaghi","year":"2018","unstructured":"Bartesaghi S, Radi R (2018) Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration. Redox Biol 14:618\u2013625. https:\/\/doi.org\/10.1016\/j.redox.2017.09.009","journal-title":"Redox Biol"},{"issue":"23","key":"3696_CR17","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1021\/jf203488k","volume":"60","author":"A Basu","year":"2012","unstructured":"Basu A, Lyons TJ (2012) Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. J Agric Food Chem 60(23):5687\u20135692. https:\/\/doi.org\/10.1021\/jf203488k","journal-title":"J Agric Food Chem"},{"key":"3696_CR18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.redox.2015.07.017","volume":"6","author":"G Bauer","year":"2015","unstructured":"Bauer G (2015) Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells. Redox Biol 6:353\u2013371. https:\/\/doi.org\/10.1016\/j.redox.2015.07.017","journal-title":"Redox Biol"},{"key":"3696_CR19","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575:688\u2013692. https:\/\/doi.org\/10.1038\/s41586-019-1705-2","journal-title":"Nature"},{"key":"3696_CR20","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/asia.200800483","volume":"4","author":"KP Bhabak","year":"2009","unstructured":"Bhabak KP, Mugesh G (2009) Amide-based glutathione peroxidase mimics: Effect of secondary and tertiary amid substituents on antioxidant activity. Chem Asian J 4:974\u2013983. https:\/\/doi.org\/10.1002\/asia.200800483","journal-title":"Chem Asian J"},{"issue":"11","key":"3696_CR21","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1021\/ar100059g","volume":"43","author":"KP Bhabak","year":"2010","unstructured":"Bhabak KP, Mugesh G (2010) Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants. Acc Chem Res 43(11):1408\u20131419. https:\/\/doi.org\/10.1021\/ar100059g","journal-title":"Acc Chem Res"},{"key":"3696_CR22","doi-asserted-by":"publisher","unstructured":"Blaner WS (2020) Vitamin A and Provitamin A Carotenoids. In: Marriott BP, Birt DF, Stallings VA, Yates AA, eds. Present Knowledge in Nutrition. 11th ed. Cambridge, Massachusetts: Wiley-Blackwell, 73\u201391. https:\/\/doi.org\/10.1016\/B978-0-323-66162-1.00005-6","DOI":"10.1016\/B978-0-323-66162-1.00005-6"},{"issue":"26","key":"3696_CR23","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1002\/anie.200700219","volume":"46","author":"SJ Blanksby","year":"2007","unstructured":"Blanksby SJ, Bierbaum VM, Ellison GB, Kato S (2007) Superoxide does react with peroxides: direct observation of the Haber-Weiss reaction in the gas phase. Angew Chem Int Ed Engl 46(26):4948\u20134950. https:\/\/doi.org\/10.1002\/anie.200700219","journal-title":"Angew Chem Int Ed Engl"},{"issue":"8","key":"3696_CR24","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/aje\/kwn414","volume":"169","author":"J Bleys","year":"2009","unstructured":"Bleys J, Navas-Acien A, Laclaustra M, Pastor-Barriuso R, Menke A, Ordovas J, Stranges S, Guallar E (2009) Serum selenium and peripheral arterial disease: results from the national health and nutrition examination survey, 2003\u20132004. Am J Epidemiol 169(8):996\u20131003. https:\/\/doi.org\/10.1093\/aje\/kwn414","journal-title":"Am J Epidemiol"},{"issue":"1","key":"3696_CR25","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jacc.2006.08.044","volume":"49","author":"S Blum","year":"2007","unstructured":"Blum S, Asaf R, Guetta J et al (2007) Haptoglobin genotype determines myocardial infarct size in diabetic mice. J Am Coll Cardiol 49(1):82\u201387. https:\/\/doi.org\/10.1016\/j.jacc.2006.08.044","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"3696_CR26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/ajcn\/80.1.143","volume":"80","author":"SL Booth","year":"2004","unstructured":"Booth SL, Golly I, Sacheck JM et al (2004) Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr 80(1):143\u2013148. https:\/\/doi.org\/10.1093\/ajcn\/80.1.143","journal-title":"Am J Clin Nutr"},{"key":"3696_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101882","volume":"41","author":"M Bortolotti","year":"2021","unstructured":"Bortolotti M, Polito L, Battelli MG, Bolognesi A (2021) Xanthine oxidoreductase: One enzyme for multiple physiological tasks. Redox Biol 41:101882. https:\/\/doi.org\/10.1016\/j.redox.2021.101882","journal-title":"Redox Biol"},{"key":"3696_CR28","first-page":"15","volume-title":"Superoxide Dismutase","author":"A Boveris","year":"1982","unstructured":"Boveris A, Cadenas E (1982) Production of superoxide radicals and hydrogen peroxide in mitochondria. In: Oberley LW (ed) Superoxide Dismutase, vol 2. CRC Press, Boca Raton, FL, pp 15\u201330"},{"key":"3696_CR29","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1021\/jp027743m","volume":"107","author":"V Brezova","year":"2003","unstructured":"Brezova V, Valko M, Breza M et al (2003a) Role of radicals and singlet oxygen in photoactivated DNA cleavage by the anticancer drug camptothecin: an electron paramagnetic resonance study. J Phys Chem 107:2415\u20132425. https:\/\/doi.org\/10.1021\/jp027743m","journal-title":"J Phys Chem"},{"key":"3696_CR30","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1021\/jp027743m","volume":"107","author":"V Brezova","year":"2003","unstructured":"Brezova V, Valko M, Breza M (2003b) Role of radicals and singlet oxygen in photoactivated DNA cleavage by the anticancer drug camptothecin: an electron paramagnetic resonance study. J Phys Chem B 107:2415\u20132425. https:\/\/doi.org\/10.1021\/jp027743m","journal-title":"J Phys Chem B"},{"key":"3696_CR31","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/ajcn\/76.4.703","volume":"76","author":"R Brigelius-Flohe","year":"2002","unstructured":"Brigelius-Flohe R, Kelly FJ, Salonen J, Neuzil J, Zingg JM, Azzi A (2002) The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 76:703\u2013716. https:\/\/doi.org\/10.1093\/ajcn\/76.4.703","journal-title":"Am J Clin Nutr"},{"key":"3696_CR32","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.freeradbiomed.2021.10.029","volume":"177","author":"R Brigelius-Floh\u00e9","year":"2021","unstructured":"Brigelius-Floh\u00e9 R (2021) Vitamin E research: Past, now and future. Free Radic Biol Med 177:381\u2013390. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.10.029","journal-title":"Free Radic Biol Med"},{"key":"3696_CR33","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/ars.2019.7905","volume":"33","author":"R Brigelius-Floh\u00e9","year":"2020","unstructured":"Brigelius-Floh\u00e9 R, Floh\u00e9 L (2020) Regulatory phenomena in the glutathione peroxidase superfamily. Antioxid Redox Signal 33:498\u2013516. https:\/\/doi.org\/10.1089\/ars.2019.7905","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"3696_CR34","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1016\/j.bbagen.2009.03.006","volume":"1790","author":"R Brigelius-Floh\u00e9","year":"2009","unstructured":"Brigelius-Floh\u00e9 R, Kipp A (2009) Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta 1790(11):1555\u20131568. https:\/\/doi.org\/10.1016\/j.bbagen.2009.03.006","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"3696_CR35","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","volume":"1830","author":"R Brigelius-Floh\u00e9","year":"2013","unstructured":"Brigelius-Floh\u00e9 R, Maiorino M (2013) Glutathione peroxidases. Biochim Biophys Acta 1830(5):3289\u20133303. https:\/\/doi.org\/10.1016\/j.bbagen.2012.11.020","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"3696_CR36","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1006\/abbi.1993.1074","volume":"300","author":"GR Buettner","year":"1993","unstructured":"Buettner GR (1993) The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 300(2):535\u2013543. https:\/\/doi.org\/10.1006\/abbi.1993.1074","journal-title":"Arch Biochem Biophys"},{"key":"3696_CR37","doi-asserted-by":"publisher","unstructured":"Burgio E, Piscitelli P, Migliore L (2018) Ionizing Radiation and Human Health: Reviewing Models of Exposure and Mechanisms of Cellular Damage. An Epigenetic Perspective. International Journal of Environmental Research and Public Health. 15(9):1971. https:\/\/doi.org\/10.3390\/ijerph15091971","DOI":"10.3390\/ijerph15091971"},{"issue":"4649","key":"3696_CR38","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.6710156","volume":"224","author":"GW Burton","year":"1984","unstructured":"Burton GW, Ingold KU (1984) beta-Carotene: an unusual type of lipid antioxidant. Science 224(4649):569\u2013573. https:\/\/doi.org\/10.1126\/science.6710156","journal-title":"Science"},{"key":"3696_CR39","doi-asserted-by":"publisher","unstructured":"Buxton GV, Wood ND, Dyster S (1988) Ionisation constants of .OH and HO2. in aqueous solution up to 200 \u00b0C. A pulse radiolysis study. Journal of the Chemical Society, Faraday Transactions 1, 84:1113\u20131121. https:\/\/doi.org\/10.1039\/F19888401113","DOI":"10.1039\/F19888401113"},{"key":"3696_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109231","volume":"726","author":"E Cadenas","year":"2022","unstructured":"Cadenas E, Boveris A, Ian Ragan C, O M Stoppani A, (2022) Reprint of: production of superoxide radicals and hydrogen peroxide by NADH- ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 726:109231. https:\/\/doi.org\/10.1016\/j.abb.2022.109231","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"3696_CR41","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1177\/088391159501000202","volume":"10","author":"P Caliceti","year":"1995","unstructured":"Caliceti P, Schiavon O, Morpurgo M et al (1995) Physico-chemical and biological properties of monofunctional hydroxy terminating poly(N-vinylpyrrolidone) conjugated superoxide dismutase. J Bioact Compat Polym 10(2):103\u2013120. https:\/\/doi.org\/10.1177\/088391159501000202","journal-title":"J Bioact Compat Polym"},{"key":"3696_CR42","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1034\/j.1600-0749.2002.00057.x","volume":"15","author":"CB Casp","year":"2002","unstructured":"Casp CB, She JX, McCormack WT (2002) Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res 15:62\u201366. https:\/\/doi.org\/10.1034\/j.1600-0749.2002.00057.x","journal-title":"Pigment Cell Res"},{"issue":"1","key":"3696_CR43","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3945\/ajcn.115.108555","volume":"102","author":"A Cassidy","year":"2015","unstructured":"Cassidy A, Rogers G, Peterson JJ et al (2015) Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Am J Clin Nutr 102(1):172\u2013181. https:\/\/doi.org\/10.3945\/ajcn.115.108555","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"3696_CR44","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/(SICI)1097-4547(20000215)59:4<497::AID-JNR4>3.0.CO;2-B","volume":"59","author":"V Castagn\u00e9","year":"2000","unstructured":"Castagn\u00e9 V, Clarke PG (2000) Neuroprotective effects of a new glutathione peroxidase mimetic on neurons of the chick embryo\u2019s retina. J Neurosci Res 59(4):497\u2013503. https:\/\/doi.org\/10.1002\/(SICI)1097-4547(20000215)59:4%3c497::AID-JNR4%3e3.0.CO;2-B","journal-title":"J Neurosci Res"},{"issue":"3","key":"3696_CR45","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1124\/jpet.107.132134","volume":"324","author":"PR Castello","year":"2008","unstructured":"Castello PR, Drechsel DA, Day BJ, Patel M (2008) Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J Pharmacol Exp Ther 324(3):970\u2013976. https:\/\/doi.org\/10.1124\/jpet.107.132134","journal-title":"J Pharmacol Exp Ther"},{"issue":"7","key":"3696_CR46","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1172\/JCI38940","volume":"119","author":"E Chabory","year":"2009","unstructured":"Chabory E, Damon C, Lenoir A et al (2009) Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J Clin Invest 119(7):2074\u20132085. https:\/\/doi.org\/10.1172\/JCI38940","journal-title":"J Clin Invest"},{"issue":"8","key":"3696_CR47","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.3390\/cancers12082197","volume":"12","author":"C Chang","year":"2020","unstructured":"Chang C, Worley BL, Pha\u00ebton R, Hempel N (2020) Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer. Cancers (basel) 12(8):2197. https:\/\/doi.org\/10.3390\/cancers12082197","journal-title":"Cancers (basel)"},{"issue":"5","key":"3696_CR48","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1021\/nn300291r","volume":"6","author":"Z Chen","year":"2012","unstructured":"Chen Z, Yin JJ, Zhou YT et al (2012) Dual enzyme-like activities of iron oxide nanoparticles and their implication for diminishing cytotoxicity. ACS Nano 6(5):4001\u20134012. https:\/\/doi.org\/10.1021\/nn300291r","journal-title":"ACS Nano"},{"issue":"10","key":"3696_CR49","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1039\/c3fo60088b","volume":"4","author":"XQ Chen","year":"2013","unstructured":"Chen XQ, Wang XB, Guan RF et al (2013) Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct 4(10):1521\u20131525. https:\/\/doi.org\/10.1039\/c3fo60088b","journal-title":"Food Funct"},{"issue":"5","key":"3696_CR50","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.3892\/or.2016.5071","volume":"36","author":"H Chen","year":"2016","unstructured":"Chen H, Zheng Z, Kim KY et al (2016) Hypermethylation and downregulation of glutathione peroxidase 3 are related to pathogenesis of melanoma. Oncol Rep 36(5):2737\u20132744. https:\/\/doi.org\/10.3892\/or.2016.5071","journal-title":"Oncol Rep"},{"issue":"46","key":"3696_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201903153","volume":"15","author":"Y Chen","year":"2019","unstructured":"Chen Y, Chen T, Wu X, Yang G (2019) Oxygen vacancy-engineered PEGylated MoO3-x nanoparticles with superior sulfite oxidase mimetic activity for vitamin b1 detection. Small 15(46):e1903153. https:\/\/doi.org\/10.1002\/smll.201903153","journal-title":"Small"},{"issue":"12","key":"3696_CR52","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.2337\/db10-0195","volume":"59","author":"P Chew","year":"2010","unstructured":"Chew P, Yuen DYC, Stefanovic N et al (2010) Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E\/GPx1-double knockout mouse. Diabetes 59(12):3198\u20133207. https:\/\/doi.org\/10.2337\/db10-0195","journal-title":"Diabetes"},{"key":"3696_CR53","doi-asserted-by":"publisher","unstructured":"Chew EY, Clemons TE, Agr\u00f3n E et al (2015) Age-Related Eye Disease Study 2 (AREDS2) Research Group. Effect of Omega-3 Fatty Acids, Lutein\/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. JAMA 314(8):791\u2013801. https:\/\/doi.org\/10.1001\/jama.2015.9677","DOI":"10.1001\/jama.2015.9677"},{"issue":"3","key":"3696_CR54","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1158\/0008-5472.can-03-2272","volume":"64","author":"FF Chu","year":"2004","unstructured":"Chu FF, Esworthy RS, Chu PG et al (2004) Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res 64(3):962\u2013968. https:\/\/doi.org\/10.1158\/0008-5472.can-03-2272","journal-title":"Cancer Res"},{"issue":"1","key":"3696_CR55","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.taap.2005.01.013","volume":"208","author":"A Churg","year":"2005","unstructured":"Churg A, Xie C, Wang X, Vincent R, Wang RD (2005) Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces. Toxicol Appl Pharmacol 208(1):37\u201345. https:\/\/doi.org\/10.1016\/j.taap.2005.01.013","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6","key":"3696_CR56","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.cell.2017.07.032","volume":"170","author":"L Cimmino","year":"2017","unstructured":"Cimmino L, Dolgalev I, Wang Y et al (2017) Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell 170(6):1079-1095.e20. https:\/\/doi.org\/10.1016\/j.cell.2017.07.032","journal-title":"Cell"},{"key":"3696_CR57","doi-asserted-by":"publisher","unstructured":"Creagan ET, Moertel CG, O'Fallon JR et al (1979) Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 301(13):687\u2013690. https:\/\/doi.org\/10.1056\/NEJM197909273011303","DOI":"10.1056\/NEJM197909273011303"},{"issue":"1","key":"3696_CR58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00006676-200301000-00005","volume":"26","author":"JJ Cullen","year":"2003","unstructured":"Cullen JJ, Mitros FA, Oberley LW (2003) Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer. Pancreas 26(1):23\u201327. https:\/\/doi.org\/10.1097\/00006676-200301000-00005","journal-title":"Pancreas"},{"issue":"13","key":"3696_CR59","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/S1359-6446(04)03139-3","volume":"9","author":"BJ Day","year":"2004","unstructured":"Day BJ (2004) Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov Today 9(13):557\u2013566. https:\/\/doi.org\/10.1016\/S1359-6446(04)03139-3","journal-title":"Drug Discov Today"},{"issue":"3","key":"3696_CR60","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.bcp.2008.09.029","volume":"77","author":"BJ Day","year":"2009","unstructured":"Day BJ (2009) Catalase and glutathione peroxidase mimics. Biochem Pharmacol 77(3):285\u2013296. https:\/\/doi.org\/10.1016\/j.bcp.2008.09.029","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"3696_CR61","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1006\/abbi.1997.0341","volume":"347","author":"BJ Day","year":"1997","unstructured":"Day BJ, Fridovich I, Crapo JD (1997) Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 347(2):256\u2013262. https:\/\/doi.org\/10.1006\/abbi.1997.0341","journal-title":"Arch Biochem Biophys"},{"issue":"5\u20136","key":"3696_CR62","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/s0891-5849(98)00261-5","volume":"26","author":"BJ Day","year":"1999","unstructured":"Day BJ, Batinic-Haberle I, Crapo JD (1999) Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 26(5\u20136):730\u2013736. https:\/\/doi.org\/10.1016\/s0891-5849(98)00261-5","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"3696_CR63","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1089\/104454902753759672","volume":"21","author":"AD De Grey","year":"2002","unstructured":"De Grey AD (2002) HO2*: the forgotten radical. DNA Cell Biol 21(4):251\u2013257. https:\/\/doi.org\/10.1089\/104454902753759672","journal-title":"DNA Cell Biol"},{"issue":"3","key":"3696_CR64","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1080\/10715760801898838","volume":"42","author":"M De la Fuente","year":"2008","unstructured":"De la Fuente M, Hernanz A, Guayerbas N (2008) Vitamin E ingestion improves several immune functions in elderly men and women. Free Radic Res 42(3):272\u2013280. https:\/\/doi.org\/10.1080\/10715760801898838","journal-title":"Free Radic Res"},{"key":"3696_CR65","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/645460","volume":"2012","author":"DG Deavall","year":"2012","unstructured":"Deavall DG, Martin EA, Horner JM (2012) Roberts R (2012) Drug-Induced Oxidative Stress and Toxicity. J Toxicol 2012:645460. https:\/\/doi.org\/10.1155\/2012\/645460","journal-title":"J Toxicol"},{"issue":"21","key":"3696_CR66","doi-asserted-by":"publisher","first-page":"8179","DOI":"10.1073\/pnas.0508218103","volume":"103","author":"V Diwadkar-Navsariwala","year":"2006","unstructured":"Diwadkar-Navsariwala V, Prins GS, Swanson SM (2006) Selenoprotein deficiency accelerates prostate carcinogenesis in a transgenic model. Proc Natl Acad Sci USA 103(21):8179\u20138184. https:\/\/doi.org\/10.1073\/pnas.0508218103","journal-title":"Proc Natl Acad Sci USA"},{"key":"3696_CR67","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s1054-3589(08)60987-4","volume":"38","author":"SR Doctrow","year":"1997","unstructured":"Doctrow SR, Huffman K, Marcus CB (1997) Salen-manganese complexes: combined superoxide dismutase\/catalase mimics with broad pharmacological efficacy. Adv Pharmacol 38:247\u2013269. https:\/\/doi.org\/10.1016\/s1054-3589(08)60987-4","journal-title":"Adv Pharmacol"},{"issue":"3","key":"3696_CR68","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1021\/am405009f","volume":"6","author":"J Dong","year":"2014","unstructured":"Dong J, Song L, Yin JJ, He W, Wu Y, Gu N, Zhang Y (2014) Co3O4 nanoparticles with multi-enzyme activities and their application in immunohistochemical assay. ACS Appl Mater Interfaces 6(3):1959\u20131570. https:\/\/doi.org\/10.1021\/am405009f","journal-title":"ACS Appl Mater Interfaces"},{"key":"3696_CR69","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bbcan.2012.06.003","volume":"2","author":"J Du","year":"1826","unstructured":"Du J, Cullen JJ (1826) Buettner GR (2012) Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta 2:443\u2013457. https:\/\/doi.org\/10.1016\/j.bbcan.2012.06.003","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"3696_CR70","doi-asserted-by":"publisher","first-page":"L425","DOI":"10.1152\/ajplung.00038.2010","volume":"299","author":"C Duong","year":"2010","unstructured":"Duong C, Seow HJ, Bozinovski S (2010) Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol 299(3):L425-433. https:\/\/doi.org\/10.1152\/ajplung.00038.2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"3696_CR71","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1161\/01.ATV.0000109955.80818.8a","volume":"24","author":"JH Dwyer","year":"2004","unstructured":"Dwyer JH, Paul-Labrador MJ, Fan J et al (2004) Progression of carotid intima-media thickness and plasma antioxidants: the Los Angeles Atherosclerosis Study. Arterioscler Thromb Vasc Biol 24(2):313\u2013319. https:\/\/doi.org\/10.1161\/01.ATV.0000109955.80818.8a","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"16","key":"3696_CR72","doi-asserted-by":"publisher","first-page":"8616","DOI":"10.1021\/jf201116y","volume":"59","author":"I Edirisinghe","year":"2011","unstructured":"Edirisinghe I, Banaszewski K, Cappozzo J et al (2011) Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. J Agric Food Chem 59(16):8616\u20138624. https:\/\/doi.org\/10.1021\/jf201116y","journal-title":"J Agric Food Chem"},{"issue":"7","key":"3696_CR73","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1080\/1028415X.2020","volume":"25","author":"CG Edwards","year":"2022","unstructured":"Edwards CG, Walk AM, Thompson SV (2022) Dietary lutein plus zeaxanthin and choline intake is interactively associated with cognitive flexibility in middle-adulthood in adults with overweight and obesity. Nutr Neurosci 25(7):1437\u20131452. https:\/\/doi.org\/10.1080\/1028415X.2020","journal-title":"Nutr Neurosci"},{"issue":"4","key":"3696_CR74","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.nutres.2012.03.007","volume":"32","author":"D Erba","year":"2012","unstructured":"Erba D, Casiraghi MC, Martinez-Conesa C, Goi G, Massaccesi L (2012) Isoflavone supplementation reduces DNA oxidative damage and increases O-\u03b2-N-acetyl-D-glucosaminidase activity in healthy women. Nutr Res 32(4):233\u2013240. https:\/\/doi.org\/10.1016\/j.nutres.2012.03.007","journal-title":"Nutr Res"},{"issue":"6","key":"3696_CR75","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2174\/1568026013394831","volume":"1","author":"N Ercal","year":"2001","unstructured":"Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 1(6):529\u2013539. https:\/\/doi.org\/10.2174\/1568026013394831","journal-title":"Curr Top Med Chem"},{"issue":"2","key":"3696_CR76","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3945\/jn.113.182659","volume":"144","author":"RV Espley","year":"2014","unstructured":"Espley RV, Butts CA, Laing WA et al (2014) Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. J Nutr 144(2):146\u2013154. https:\/\/doi.org\/10.3945\/jn.113.182659","journal-title":"J Nutr"},{"issue":"2","key":"3696_CR77","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0891-5849(89)90015-4","volume":"7","author":"H Esterbauer","year":"1989","unstructured":"Esterbauer H, Zollner H (1989) Methods for determination of aldehydic lipid peroxidation products. Free Radic Biol Med 7(2):197\u2013203. https:\/\/doi.org\/10.1016\/0891-5849(89)90015-4","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"3696_CR78","doi-asserted-by":"publisher","first-page":"G848","DOI":"10.1152\/ajpgi.2001.281.3.G848","volume":"281","author":"RS Esworthy","year":"2001","unstructured":"Esworthy RS, Aranda R, Mart\u00edn MG (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol 281(3):G848\u2013G855. https:\/\/doi.org\/10.1152\/ajpgi.2001.281.3.G848","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"18","key":"3696_CR79","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1039\/d0cs00579g","volume":"49","author":"AM Fleming","year":"2020","unstructured":"Fleming AM, Burrows CJ (2020) On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics. Chem Soc Rev 49(18):6524\u20136528. https:\/\/doi.org\/10.1039\/d0cs00579g","journal-title":"Chem Soc Rev"},{"key":"3696_CR80","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.freeradbiomed.2022.05.003","volume":"187","author":"L Floh\u00e9","year":"2022","unstructured":"Floh\u00e9 L, Toppo S, Orian L (2022) The glutathione peroxidase family: Discoveries and mechanism. Free Radic Biol Med 187:113\u2013122. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.05.003","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"3696_CR81","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","volume":"20","author":"HJ Forman","year":"2021","unstructured":"Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 20(9):689\u2013709. https:\/\/doi.org\/10.1038\/s41573-021-00233-1","journal-title":"Nat Rev Drug Discov"},{"key":"3696_CR82","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"J Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli J, Schneider M, Proneth B et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180\u20131191. https:\/\/doi.org\/10.1038\/ncb3064","journal-title":"Nat Cell Biol"},{"issue":"10","key":"3696_CR83","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.3390\/molecules28104085","volume":"28","author":"J Fujii","year":"2023","unstructured":"Fujii J, Soma Y, Matsuda Y (2023) Biological action of singlet molecular oxygen from the standpoint of cell signaling. Injury and Death Molecules 28(10):4085. https:\/\/doi.org\/10.3390\/molecules28104085","journal-title":"Injury and Death Molecules"},{"issue":"3","key":"3696_CR84","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/S0006-3495(03)74574-3","volume":"85","author":"RR Gabdoulline","year":"2003","unstructured":"Gabdoulline RR, Kummer U, Olsen LF, Wade RC (2003) Concerted simulations reveal how peroxidase compound III formation results in cellular oscillations. Biophys J 85(3):1421\u20131428. https:\/\/doi.org\/10.1016\/S0006-3495(03)74574-3","journal-title":"Biophys J"},{"key":"3696_CR85","unstructured":"Gamna F (2021) E Scholarly Community Encyclopedia, Biochemical Research methods, https:\/\/encyclopedia.pub\/entry\/11948"},{"key":"3696_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101550","volume":"34","author":"BN Gantner","year":"2020","unstructured":"Gantner BN, LaFond KM, Bonini MG (2020) Nitric oxide in cellular adaptation and disease. Redox Biol 34:101550. https:\/\/doi.org\/10.1016\/j.redox.2020.101550","journal-title":"Redox Biol"},{"issue":"9","key":"3696_CR87","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nnano.2007.2607","volume":"2","author":"L Gao","year":"2007","unstructured":"Gao L, Zhuang J, Nie L et al (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol 2(9):577\u2013583. https:\/\/doi.org\/10.1038\/nnano.2007.2607","journal-title":"Nat Nanotechnol"},{"issue":"2","key":"3696_CR88","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/bph.14522","volume":"176","author":"V Garcia","year":"2019","unstructured":"Garcia V, Sessa WC (2019) Endothelial NOS: perspective and recent developments. Br J Pharmacol 176(2):189\u2013196. https:\/\/doi.org\/10.1111\/bph.14522","journal-title":"Br J Pharmacol"},{"issue":"1","key":"3696_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100005","volume":"1","author":"M Garland","year":"2020","unstructured":"Garland M, Hryckowian AJ, Tholen M et al (2020) The clinical drug ebselen attenuates inflammation and promotes microbiome recovery in mice after antibiotic treatment for CDI. Cell Rep Med 1(1):100005. https:\/\/doi.org\/10.1016\/j.xcrm.2020.100005","journal-title":"Cell Rep Med"},{"issue":"10","key":"3696_CR90","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1515\/hsz-2017-0131","volume":"398","author":"C Glorieux","year":"2017","unstructured":"Glorieux C, Calderon PB (2017) Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach. Biol Chem 398(10):1095\u20131108. https:\/\/doi.org\/10.1515\/hsz-2017-0131","journal-title":"Biol Chem"},{"key":"3696_CR91","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12935-018-0524-0","volume":"18","author":"C Glorieux","year":"2018","unstructured":"Glorieux C, Calderon PB (2018) Catalase down-regulation in cancer cells exposed to arsenic trioxide is involved in their increased sensitivity to a pro-oxidant treatment. Cancer Cell Int 18:24. https:\/\/doi.org\/10.1186\/s12935-018-0524-0","journal-title":"Cancer Cell Int"},{"issue":"4","key":"3696_CR92","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1080\/00039896.1969.10665464","volume":"18","author":"BD Goldstein","year":"1969","unstructured":"Goldstein BD, Lodi C, Collinson C, Balchum OJ (1969) Ozone and lipid peroxidation. Arch Environ Health 18(4):631\u2013635. https:\/\/doi.org\/10.1080\/00039896.1969.10665464","journal-title":"Arch Environ Health"},{"issue":"3","key":"3696_CR93","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1161\/01.HYP.0000235682.47673.ab","volume":"48","author":"MC Gongora","year":"2006","unstructured":"Gongora MC, Qin Z, Laude K et al (2006) Role of extracellular superoxide dismutase in hypertension. Hypertension 48(3):473\u2013481. https:\/\/doi.org\/10.1161\/01.HYP.0000235682.47673.ab","journal-title":"Hypertension"},{"issue":"5","key":"3696_CR94","doi-asserted-by":"publisher","first-page":"977","DOI":"10.3390\/nu11050977","volume":"11","author":"GNY Gorkom","year":"2019","unstructured":"Gorkom GNY, Lookermans EL, Van Elssen CHMJ, Bos GMJ (2019) The effect of vitamin C (Ascorbic Acid) in the treatment of patients with cancer: a systematic review. Nutrients 11(5):977. https:\/\/doi.org\/10.3390\/nu11050977","journal-title":"Nutrients"},{"key":"3696_CR95","doi-asserted-by":"publisher","first-page":"1681254","DOI":"10.1155\/2019\/1681254","volume":"2019","author":"V Granatiero","year":"2019","unstructured":"Granatiero V, Pacifici M, Raffaello A et al (2019) Overexpression of mitochondrial calcium uniporter causes neuronal death. Oxid Med Cell Longev 2019:1681254. https:\/\/doi.org\/10.1155\/2019\/1681254","journal-title":"Oxid Med Cell Longev"},{"issue":"9","key":"3696_CR96","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1093\/jn\/138.9.1671","volume":"138","author":"D Grassi","year":"2008","unstructured":"Grassi D, Desideri G, Necozione S et al (2008) Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15\u00a0days of consuming high-polyphenol dark chocolate. J Nutr 138(9):1671\u20131676. https:\/\/doi.org\/10.1093\/jn\/138.9.1671","journal-title":"J Nutr"},{"key":"3696_CR97","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.freeradbiomed.2017.08.013","volume":"112","author":"B Griess","year":"2017","unstructured":"Griess B, Tom E, Domann F et al (2017) Extracellular superoxide dismutase and its role in cancer. Free Radic Biol Med 112:464\u2013479. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.08.013","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"3696_CR98","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","volume":"94","author":"\u0130 Gulcin","year":"2020","unstructured":"Gulcin \u0130 (2020) Antioxidants and antioxidant methods: an updated overview. Arch Toxicol 94(3):651\u2013715. https:\/\/doi.org\/10.1007\/s00204-020-02689-3","journal-title":"Arch Toxicol"},{"issue":"2","key":"3696_CR99","doi-asserted-by":"publisher","first-page":"709","DOI":"10.2741\/s182","volume":"3","author":"JB Haan","year":"2011","unstructured":"Haan JB, Cooper ME (2011) Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction. Front Biosci (schol Ed) 3(2):709\u2013729. https:\/\/doi.org\/10.2741\/s182","journal-title":"Front Biosci (schol Ed)"},{"key":"3696_CR100","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1007\/BF01504715","volume":"20","author":"F Haber","year":"1932","unstructured":"Haber F, Weiss J (1932) \u00dcber die Katalyse des Hydroperoxydes. Naturwissenschaften 20:948\u2013950. https:\/\/doi.org\/10.1007\/BF01504715","journal-title":"Naturwissenschaften"},{"issue":"1","key":"3696_CR101","first-page":"7","volume":"45","author":"K Hadjigogos","year":"2003","unstructured":"Hadjigogos K (2003) The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med 45(1):7\u201313","journal-title":"Panminerva Med"},{"issue":"9","key":"3696_CR102","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1080\/10715762.2018","volume":"52","author":"B Halliwell","year":"2018","unstructured":"Halliwell B (2018) Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media. Free Radic Res 52(9):907\u2013909. https:\/\/doi.org\/10.1080\/10715762.2018","journal-title":"Free Radic Res"},{"key":"3696_CR103","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bbrc.2022.08.098","volume":"633","author":"B Halliwell","year":"2022","unstructured":"Halliwell B (2022) Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go? Biochem Biophys Res Commun 633:17\u201319. https:\/\/doi.org\/10.1016\/j.bbrc.2022.08.098","journal-title":"Biochem Biophys Res Commun"},{"key":"3696_CR309","doi-asserted-by":"publisher","unstructured":"Halliwell B (2024) Understanding mechanisms of antioxidant action in health and disease. Nat Rev Mol Cell Biol 25(1):13\u201333. https:\/\/doi.org\/10.1038\/s41580-023-00645-4","DOI":"10.1038\/s41580-023-00645-4"},{"key":"3696_CR105","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jcis.2018.12.093","volume":"539","author":"Q Han","year":"2019","unstructured":"Han Q, Wang X, Liu X (2019) MoO3-x nanodots with dual enzyme mimic activities as multifunctional modulators for amyloid assembly and neurotoxicity. J Colloid Interface Sci 539:575\u2013584. https:\/\/doi.org\/10.1016\/j.jcis.2018.12.093","journal-title":"J Colloid Interface Sci"},{"key":"3696_CR106","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2022.06.004","volume":"188","author":"DE Handy","year":"2022","unstructured":"Handy DE, Loscalzo J (2022) The role of glutathione peroxidase-1 in health and disease. Free Radic Biol Med 188:146\u2013161. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.06.004","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"3696_CR107","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3390\/ijms11041365","volume":"11","author":"K Hanhineva","year":"2010","unstructured":"Hanhineva K, T\u00f6rr\u00f6nen R et al (2010) Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci 11(4):1365\u20131402. https:\/\/doi.org\/10.3390\/ijms11041365","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3696_CR108","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1021\/jacs.8b11856","volume":"141","author":"C Hao","year":"2019","unstructured":"Hao C, Qu A, Xu L (2019) Chiral molecule-mediated porous Cu xO nanoparticle clusters with antioxidation activity for ameliorating Parkinson\u2019s disease. J Am Chem Soc 141(2):1091\u20131099. https:\/\/doi.org\/10.1021\/jacs.8b11856","journal-title":"J Am Chem Soc"},{"issue":"5","key":"3696_CR109","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","volume":"116","author":"M Hayyan","year":"2016","unstructured":"Hayyan M, Hashim MA, AlNashef IM (2016) Superoxide Ion: generation and chemical implications. Chem Rev 116(5):3029\u20133085. https:\/\/doi.org\/10.1021\/acs.chemrev.5b00407","journal-title":"Chem Rev"},{"issue":"2","key":"3696_CR110","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s12263-011-0263-5","volume":"7","author":"M Hidalgo","year":"2012","unstructured":"Hidalgo M, Martin-Santamaria S, Recio I et al (2012) Potential anti-inflammatory, anti-adhesive, anti\/estrogenic, and angiotensin-converting enzyme inhibitory activities of anthocyanins and their gut metabolites. Genes Nutr 7(2):295\u2013306. https:\/\/doi.org\/10.1007\/s12263-011-0263-5","journal-title":"Genes Nutr"},{"key":"3696_CR111","unstructured":"Higdon J, Drake VJ, Angelo G (2023a) Vitamin C, Micronutrient information center, Linus Pauling Institute, Oregon 2023, https:\/\/lpi.oregonstate.edu\/mic\/vitamins\/vitamin-C Accessed Nov 18 2023."},{"key":"3696_CR112","unstructured":"Higdon J, Drake VJ, Angelo G, Delage B, Traber MG (2023b) Vitamin E, Micronutrient information center, Linus Pauling Institute, Oregon 2023, https:\/\/lpi.oregonstate.edu\/mic\/vitamins\/vitamin-E Accessed Nov 18, 2023."},{"key":"3696_CR113","unstructured":"Higdon J, Drake VJ, Delage B, Crozier A (2023d) Flavonoids, Phytochemicals, Linus Pauling Institute, Oregon 2023, https:\/\/lpi.oregonstate.edu\/mic\/dietary-factors\/phytochemicals\/flavonoids Accessed Nov 18, 2023."},{"key":"3696_CR114","unstructured":"Higdon J, Drake VJ, Delage B, Johnson EJ (2023c) Carotenoids, Phytochemicals, Linus Pauling Institute, Oregon 2023, https:\/\/lpi.oregonstate.edu\/mic\/dietary-factors\/phytochemicals\/carotenoids Accessed Nov 18, 2023."},{"issue":"1\u20132","key":"3696_CR115","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mrfmmm.2004.06.040","volume":"555","author":"Z Hou","year":"2004","unstructured":"Hou Z, Lambert JD, Chin KV, Yang CS (2004) Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutat Res 555(1\u20132):3\u201319. https:\/\/doi.org\/10.1016\/j.mrfmmm.2004.06.040","journal-title":"Mutat Res"},{"issue":"3","key":"3696_CR116","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1021\/jacs.9b13586","volume":"142","author":"X Hu","year":"2020","unstructured":"Hu X, Li F, Xia F et al (2020) Biodegradation-mediated enzymatic activity-tunable molybdenum oxide nanourchins for tumor-specific cascade catalytic therapy. J Am Chem Soc 142(3):1636\u20131644. https:\/\/doi.org\/10.1021\/jacs.9b13586","journal-title":"J Am Chem Soc"},{"issue":"21","key":"3696_CR117","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1039\/c7cc00045f","volume":"53","author":"Y Huang","year":"2017","unstructured":"Huang Y, Liu C, Pu F (2017) A GO-Se nanocomposite as an antioxidant nanozyme for cytoprotection. Chem Commun (camb) 53(21):3082\u20133085. https:\/\/doi.org\/10.1039\/c7cc00045f","journal-title":"Chem Commun (camb)"},{"issue":"2","key":"3696_CR118","first-page":"173","volume":"4","author":"W Huber","year":"1981","unstructured":"Huber W (1981) Orgotein\u2013(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology. Eur J Rheumatol Inflamm 4(2):173\u2013182","journal-title":"Eur J Rheumatol Inflamm"},{"key":"3696_CR119","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54:287\u2013293. https:\/\/doi.org\/10.1016\/j.ajme.2017.09.001","journal-title":"Alexandria J Med"},{"key":"3696_CR120","doi-asserted-by":"publisher","unstructured":"Islinger M, Voelkl A, Fahimi HD, Schrader M (2018) The peroxisome: an update on mysteries 2.0. Histochem Cell Biol 150(5):443\u2013471. https:\/\/doi.org\/10.1007\/s00418-018-1722-5","DOI":"10.1007\/s00418-018-1722-5"},{"key":"3696_CR121","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2015.01.031","volume":"83","author":"MC Jaramillo","year":"2015","unstructured":"Jaramillo MC, Briehl MM, Batinic-Haberle I et al (2015) Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. Free Radic Biol Med 83:89\u2013100. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.01.031","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"3696_CR122","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1179\/147683008X301450","volume":"11","author":"EJ Johnson","year":"2008","unstructured":"Johnson EJ, McDonald K, Caldarella SM et al (2008) Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci 11(2):75\u201383. https:\/\/doi.org\/10.1179\/147683008X301450","journal-title":"Nutr Neurosci"},{"issue":"2","key":"3696_CR123","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1124\/dmd.112.048009","volume":"41","author":"CH Johnson","year":"2013","unstructured":"Johnson CH, Bonzo JA, Cheng J (2013a) Cytochrome P450 regulation by \u03b1-tocopherol in Pxr-null and PXR-humanized mice. Drug Metab Dispos 41(2):406\u2013413. https:\/\/doi.org\/10.1124\/dmd.112.048009","journal-title":"Drug Metab Dispos"},{"key":"3696_CR124","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/951786","volume":"2013","author":"EJ Johnson","year":"2013","unstructured":"Johnson EJ, Vishwanathan R, Johnson MA et al (2013b) Relationship between serum and brain carotenoids, \u03b1-tocopherol, and retinol concentrations and cognitive performance in the oldest old from the Georgia centenarian study. J Aging Res 2013:951786. https:\/\/doi.org\/10.1155\/2013\/951786","journal-title":"J Aging Res"},{"key":"3696_CR125","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ejmech.2013.09.054","volume":"70","author":"K Jomova","year":"2013","unstructured":"Jomova K, Valko M (2013) Health protective effects of carotenoids and their interactions with other biological antioxidants. Eur J Med Chem 70:102\u2013110. https:\/\/doi.org\/10.1016\/j.ejmech.2013.09.054","journal-title":"Eur J Med Chem"},{"key":"3696_CR126","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.cplett.2009.07.088","volume":"478","author":"K Jomova","year":"2009","unstructured":"Jomova K, Kysel O, Madden JC et al (2009) Electron transfer from all-trans \u03b2-carotene to the t-butyl peroxyl radical at low oxygen pressure (an EPR spectroscopy and computational study). Chem Phys Letters 478:266\u2013270. https:\/\/doi.org\/10.1016\/j.cplett.2009.07.088","journal-title":"Chem Phys Letters"},{"key":"3696_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110173","volume":"367","author":"K Jomova","year":"2022","unstructured":"Jomova K, Makova M, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Rhodes CJ, Valko M (2022) Essential metals in health and disease. Chem Biol Interact 367:110173. https:\/\/doi.org\/10.1016\/j.cbi.2022.110173","journal-title":"Chem Biol Interact"},{"issue":"10","key":"3696_CR128","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Valko M (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97(10):2499\u20132574. https:\/\/doi.org\/10.1007\/s00204-023-03562-9","journal-title":"Arch Toxicol"},{"issue":"23","key":"3696_CR129","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.3390\/molecules24234335","volume":"24","author":"K Jomov\u00e1","year":"2019","unstructured":"Jomov\u00e1 K, Hudecova L, Lauro P, Simunkova M, Alwasel SH, Alhazza IM, Valko M (2019) A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3\u2019,4\u2019-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study. Molecules 24(23):4335. https:\/\/doi.org\/10.3390\/molecules24234335","journal-title":"Molecules"},{"key":"3696_CR130","doi-asserted-by":"publisher","unstructured":"Jomova K, Valko M (2011) Thermodynamics of free radical reactions and the redox environment of a cell in oxidative stress: diagnostics, prevention, and therapy, ACS, pp 71\u201382 https:\/\/doi.org\/10.1021\/bk-2011-1083.ch003","DOI":"10.1021\/bk-2011-1083.ch003"},{"issue":"9\u201310","key":"3696_CR131","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1016\/s0891-5849(98)00325-6","volume":"26","author":"A J\u00f6rns","year":"1999","unstructured":"J\u00f6rns A, Tiedge M, Lenzen S, Munday R (1999) Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro. Free Radic Biol Med 26(9\u201310):1300\u20131304. https:\/\/doi.org\/10.1016\/s0891-5849(98)00325-6","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"3696_CR132","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.freeradbiomed.2008.07.006","volume":"45","author":"A Joseph","year":"2008","unstructured":"Joseph A, Li Y, Koo HC, Davis JM, Pollack S, Kazzaz JA (2008) Superoxide dismutase attenuates hyperoxia-induced interleukin-8 induction via AP-1. Free Radic Biol Med 45(8):1143\u20131149. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.07.006","journal-title":"Free Radic Biol Med"},{"key":"3696_CR133","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1039\/P29960002497","volume":"2","author":"SV Jovanovic","year":"1996","unstructured":"Jovanovic SV, Steenken S, Hara Y, Simic MG (1996) Reduction potentials of flavonoid and model phenoxyl radicals. Which ring in flavonoids is responsible for antioxidant activity? J Chem Soc Perkin Trans 2:2497\u20132504. https:\/\/doi.org\/10.1039\/P29960002497","journal-title":"J Chem Soc Perkin Trans"},{"issue":"1","key":"3696_CR134","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bcp.2003.08.036","volume":"67","author":"R Kachadourian","year":"2004","unstructured":"Kachadourian R, Johnson CA, Min E et al (2004) Flavin-dependent antioxidant properties of a new series of meso-N, N\u2019-dialkyl-imidazolium substituted manganese(III) porphyrins. Biochem Pharmacol 67(1):77\u201385. https:\/\/doi.org\/10.1016\/j.bcp.2003.08.036","journal-title":"Biochem Pharmacol"},{"issue":"36","key":"3696_CR135","doi-asserted-by":"publisher","first-page":"12772","DOI":"10.1074\/jbc.RA120.013607","volume":"295","author":"S Kanemura","year":"2020","unstructured":"Kanemura S, Sofia EF, Hirai N et al (2020) Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding. J Biol Chem 295(36):12772\u201312785. https:\/\/doi.org\/10.1074\/jbc.RA120.013607","journal-title":"J Biol Chem"},{"issue":"5","key":"3696_CR136","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/ana.20476","volume":"57","author":"JH Kang","year":"2005","unstructured":"Kang JH, Ascherio A, Grodstein F (2005) Fruit and vegetable consumption and cognitive decline in aging women. Ann Neurol 57(5):713\u2013720. https:\/\/doi.org\/10.1002\/ana.20476","journal-title":"Ann Neurol"},{"key":"3696_CR137","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1039\/C2971000649B","volume":"12","author":"I Kapovits","year":"1971","unstructured":"Kapovits I, Kalman A (1971) Formation and structure of a four-co-ordinate Organo-Sulphur (IV) compound. Chem Commun 12:649\u2013650","journal-title":"Chem Commun"},{"issue":"8","key":"3696_CR138","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.neuint.2005.02.006","volume":"46","author":"S Kasparov\u00e1","year":"2005","unstructured":"Kasparov\u00e1 S, Brezov\u00e1 V, Valko M et al (2005) Study of the oxidative stress in a rat model of chronic brain hypoperfusion. Neurochem Int 46(8):601\u2013611. https:\/\/doi.org\/10.1016\/j.neuint.2005.02.006","journal-title":"Neurochem Int"},{"issue":"3","key":"3696_CR139","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3109\/07853890903508887","volume":"42","author":"MK Kataja-Tuomola","year":"2010","unstructured":"Kataja-Tuomola MK, Kontto JP, M\u00e4nnist\u00f6 S et al (2010) Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. Ann Med 42(3):178\u2013186. https:\/\/doi.org\/10.3109\/07853890903508887","journal-title":"Ann Med"},{"issue":"11","key":"3696_CR140","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.nutres.2014.07.010","volume":"34","author":"A Kaulmann","year":"2014","unstructured":"Kaulmann A, Bohn T (2014) Carotenoids, inflammation, and oxidative stress\u2013implications of cellular signaling pathways and relation to chronic disease prevention. Nutr Res 34(11):907\u2013929. https:\/\/doi.org\/10.1016\/j.nutres.2014.07.010","journal-title":"Nutr Res"},{"issue":"4","key":"3696_CR141","doi-asserted-by":"publisher","first-page":"311","DOI":"10.4103\/2229-5178.185494","volume":"7","author":"MA Keen","year":"2016","unstructured":"Keen MA, Hassan I (2016) Vitamin E in dermatology. Indian Dermatol Online J 7(4):311\u2013315. https:\/\/doi.org\/10.4103\/2229-5178.185494","journal-title":"Indian Dermatol Online J"},{"issue":"1","key":"3696_CR142","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3233\/JAD-150199","volume":"48","author":"D Kelly","year":"2015","unstructured":"Kelly D, Coen RF, Akuffo KO et al (2015) Cognitive function and its relationship with macular pigment optical density and serum concentrations of its constituent carotenoids. J Alzheimers Dis 48(1):261\u2013277. https:\/\/doi.org\/10.3233\/JAD-150199","journal-title":"J Alzheimers Dis"},{"key":"3696_CR143","doi-asserted-by":"crossref","unstructured":"Kipp AP (2019) GPx2. Role in physiology and carcinogenesis. In: Glutathione, edited by Floh\u00e9 L. Boca Raton, FL: CRC Press, pp. 95\u2013109.","DOI":"10.1201\/9781351261760-8"},{"issue":"14","key":"3696_CR144","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1001\/jama.2011.1437","volume":"306","author":"EA Klein","year":"2011","unstructured":"Klein EA, Thompson IM Jr, Tangen CM et al (2011) Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306(14):1549\u20131556. https:\/\/doi.org\/10.1001\/jama.2011.1437","journal-title":"JAMA"},{"issue":"12","key":"3696_CR145","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/oxfordjournals.aje.a116964","volume":"139","author":"P Knekt","year":"1994","unstructured":"Knekt P, Reunanen A, J\u00e4rvinen R et al (1994) Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 139(12):1180\u20131189. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a116964","journal-title":"Am J Epidemiol"},{"key":"3696_CR146","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-023-01706-6","author":"LD Kolibius","year":"2023","unstructured":"Kolibius LD, Roux F, Parish G et al (2023) Hippocampal neurons code individual episodic memories in humans. Nat Hum Behav. https:\/\/doi.org\/10.1038\/s41562-023-01706-6","journal-title":"Nat Hum Behav"},{"key":"3696_CR147","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/10.1196\/annals.1331.025","volume":"1031","author":"K Kontush","year":"2004","unstructured":"Kontush K, Schekatolina S (2004) Vitamin E in neurodegenerative disorders: Alzheimer\u2019s disease. Ann N Y Acad Sci 1031:249\u2013262. https:\/\/doi.org\/10.1093\/10.1196\/annals.1331.025","journal-title":"Ann N Y Acad Sci"},{"key":"3696_CR148","doi-asserted-by":"publisher","unstructured":"Koo S, Park OK, Kim J et al (2022) Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction. ACS Nano 16(2):2535\u20132545. https:\/\/doi.org\/10.1093\/10.1021\/acsnano.1c09171","DOI":"10.1093\/10.1021\/acsnano.1c09171"},{"issue":"3","key":"3696_CR149","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2010.04.011","volume":"49","author":"WH Koppenol","year":"2010","unstructured":"Koppenol WH, Stanbury DM, Bounds PL (2010) Electrode potentials of partially reduced oxygen species, from dioxygen to water. Free Radic Biol Med 49(3):317\u2013322. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.04.011","journal-title":"Free Radic Biol Med"},{"key":"3696_CR150","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1039\/C6NR09810J","volume":"9","author":"K Korschelt","year":"2017","unstructured":"Korschelt K, Ragg R, Metzger CS et al (2017) Glycine-functionalized copper(II) hydroxide nanoparticles with high intrinsic superoxide dismutase activity. Nanoscale 9:3952\u20133960. https:\/\/doi.org\/10.1039\/C6NR09810J","journal-title":"Nanoscale"},{"issue":"8","key":"3696_CR151","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3390\/ph14080723","volume":"14","author":"J Kowalska","year":"2021","unstructured":"Kowalska J, Rok J, Rzepka Z, Wrze\u015bniok D (2021) Drug-induced photosensitivity-from light and chemistry to biological reactions and clinical symptoms. Pharmaceuticals (basel) 14(8):723. https:\/\/doi.org\/10.3390\/ph14080723","journal-title":"Pharmaceuticals (basel)"},{"issue":"3","key":"3696_CR152","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1093\/carcin\/bgr288","volume":"33","author":"S Krehl","year":"2012","unstructured":"Krehl S, Loewinger M, Florian S et al (2012) Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. Carcinogenesis 33(3):620\u2013628. https:\/\/doi.org\/10.1093\/carcin\/bgr288","journal-title":"Carcinogenesis"},{"issue":"3","key":"3696_CR153","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/s0006-291x(03)00816-7","volume":"305","author":"NI Krinsky","year":"2003","unstructured":"Krinsky NI, Yeum KJ (2003) Carotenoid-radical interactions. Biochem Biophys Res Commun 305(3):754\u2013760. https:\/\/doi.org\/10.1016\/s0006-291x(03)00816-7","journal-title":"Biochem Biophys Res Commun"},{"key":"3696_CR154","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1146\/annurev.nutr.23.011702.073307","volume":"23","author":"NI Krinsky","year":"2003","unstructured":"Krinsky NI, Landrum JT, Bone RA (2003) Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr 23:171\u2013201. https:\/\/doi.org\/10.1146\/annurev.nutr.23.011702.073307","journal-title":"Annu Rev Nutr"},{"key":"3696_CR155","unstructured":"Krinsky NI Food and Nutrition Board, Institute of Medicine. Vitamin E. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, D.C.: National Academy Press; 2000:186\u2013283"},{"issue":"1","key":"3696_CR156","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/jn\/129.1.5","volume":"129","author":"SB Kritchevsky","year":"1999","unstructured":"Kritchevsky SB (1999) beta-Carotene, carotenoids, and the prevention of coronary heart disease. J Nutr 129(1):5\u20138. https:\/\/doi.org\/10.1093\/jn\/129.1.5","journal-title":"J Nutr"},{"key":"3696_CR157","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00394-015-0910-5","volume":"55","author":"P Kubatka","year":"2016","unstructured":"Kubatka P, Kapinov\u00e1 A, Kello M et al (2016) Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer. Eur J Nutr 55:955\u2013965. https:\/\/doi.org\/10.1007\/s00394-015-0910-5","journal-title":"Eur J Nutr"},{"issue":"18","key":"3696_CR158","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1056\/NEJM199605023341803","volume":"334","author":"LH Kushi","year":"1996","unstructured":"Kushi LH, Folsom AR, Prineas RJ et al (1996) Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 334(18):1156\u20131162. https:\/\/doi.org\/10.1056\/NEJM199605023341803","journal-title":"N Engl J Med"},{"issue":"5","key":"3696_CR159","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/gerona\/glu090","volume":"70","author":"HB Kwak","year":"2015","unstructured":"Kwak HB, Lee Y, Kim JH et al (2015) MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. J Gerontol A Biol Sci Med Sci 70(5):533\u2013544. https:\/\/doi.org\/10.1093\/gerona\/glu090","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"3696_CR160","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1083\/jcb.59.2.507","volume":"59","author":"PB Lazarow","year":"1973","unstructured":"Lazarow PB, De Duve C (1973) The synthesis and turnover of rat liver peroxisomes. V. Intracellular pathway of catalase synthesis. J Cell Biol 59:507\u2013524. https:\/\/doi.org\/10.1083\/jcb.59.2.507","journal-title":"J Cell Biol"},{"key":"3696_CR161","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3390\/nu10111614","volume":"10","author":"GY Lee","year":"2018","unstructured":"Lee GY, Han SN (2018) The role of vitamin E in immunity. Nutrients 10:1614. https:\/\/doi.org\/10.3390\/nu10111614","journal-title":"Nutrients"},{"key":"3696_CR162","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023","volume":"559","author":"J Lee","year":"2023","unstructured":"Lee J, Roh JL (2023) Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience. Cancer Lett 559:216119. https:\/\/doi.org\/10.1016\/j.canlet.2023","journal-title":"Cancer Lett"},{"key":"3696_CR163","first-page":"2510","volume":"47","author":"R Lesser","year":"1914","unstructured":"Lesser R, Weiss R (1914) \u00dcber Selenoxanthon und Selenoxanthon-carbons\u00e4ure. \u00dcber Selenhaltige Aromatische Verbindungen \u00dcber BerDtsch Chemische Berichte 47:2510\u20132525","journal-title":"\u00dcber Selenhaltige Aromatische Verbindungen \u00dcber BerDtsch Chemische Berichte"},{"key":"3696_CR164","doi-asserted-by":"publisher","unstructured":"Lewandowska H (2013). Coordination Chemistry of Nitrosyls and Its Biochemical Implications. In: Mingos, D. (eds) Nitrosyl Complexes in Inorganic Chemistry, Biochemistry and Medicine I. Structure and Bonding, vol 153. Springer, Berlin, Heidelberg. https:\/\/doi.org\/10.1007\/430_2013_102","DOI":"10.1007\/430_2013_102"},{"key":"3696_CR165","doi-asserted-by":"publisher","unstructured":"Lewis TJ, Trempe CL, Chapter 7 - Inflammation Friend or Foe?, Editor(s): Thomas J. Lewis, Clement L. Trempe, The End of Alzheimer's (Second Edition), Academic Press, 2017, Pages 192\u2013241. https:\/\/doi.org\/10.1016\/B978-0-12-812112-2.00007-0","DOI":"10.1016\/B978-0-12-812112-2.00007-0"},{"key":"3696_CR166","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12964-018-0240-3","volume":"16","author":"S Li","year":"2018","unstructured":"Li S, Fu L, Tian T (2018) Disrupting SOD1 activity inhibits cell growth and enhances lipid accumulation in nasopharyngeal carcinoma. Cell Commun Signal 16:28. https:\/\/doi.org\/10.1186\/s12964-018-0240-3","journal-title":"Cell Commun Signal"},{"key":"3696_CR167","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Hl Y et al (2020a) Ferroptosis: past, present and future. Cell Death Dis 11:88. https:\/\/doi.org\/10.1038\/s41419-020-2298-2","journal-title":"Cell Death Dis"},{"key":"3696_CR168","doi-asserted-by":"publisher","first-page":"13737","DOI":"10.1074\/jbc.RA120.013805","volume":"295","author":"K Li","year":"2020","unstructured":"Li K, Liu T, Chen J et al (2020b) Survivin in breast cancer\u2013derived exosomes activates fibroblasts by up-regulating SOD1, whose feedback promotes cancer proliferation and metastasis. J Biol Chem 295:13737\u201313752. https:\/\/doi.org\/10.1074\/jbc.RA120.013805","journal-title":"J Biol Chem"},{"key":"3696_CR169","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.627700","volume":"9","author":"C Li","year":"2021","unstructured":"Li C, Qian T, He R et al (2021) Endoplasmic reticulum-plasma membrane contact sites: regulators, mechanisms, and physiological functions. Front Cell Dev Biol 9:627700. https:\/\/doi.org\/10.3389\/fcell.2021.627700","journal-title":"Front Cell Dev Biol"},{"key":"3696_CR170","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.898204","volume":"13","author":"S Li","year":"2022","unstructured":"Li S, Jiang X, Guan M et al (2022) The overexpression of GPX8 is correlated with poor prognosis in GBM patients. Front Genet 13:898204. https:\/\/doi.org\/10.3389\/fgene.2022.898204","journal-title":"Front Genet"},{"issue":"27","key":"3696_CR171","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902123","volume":"16","author":"S Lin","year":"2020","unstructured":"Lin S, Cheng Y, Zhang H et al (2020) Copper tannic acid coordination nanosheet: a potent nanozyme for scavenging ros from cigarette smoke. Small 16(27):e1902123. https:\/\/doi.org\/10.1002\/smll.201902123","journal-title":"Small"},{"issue":"1","key":"3696_CR172","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jama.2008.864","volume":"301","author":"SM Lippman","year":"2009","unstructured":"Lippman SM, Klein EA, Goodman PJ et al (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301(1):39\u201351. https:\/\/doi.org\/10.1001\/jama.2008.864","journal-title":"JAMA"},{"key":"3696_CR173","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2165\/00139709-200524040-00006","volume":"24","author":"MH Litchfield","year":"2005","unstructured":"Litchfield MH (2005) Estimates of acute pesticide poisoning in agriculturalworkers in less developed countries. Toxicol Rev 24:271\u2013278. https:\/\/doi.org\/10.2165\/00139709-200524040-00006","journal-title":"Toxicol Rev"},{"key":"3696_CR174","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1038\/s41467-020-16544-7","volume":"11","author":"T Liu","year":"2020","unstructured":"Liu T, Xiao B, Xiang F et al (2020) Ultrasmall copper-based nanoparticles for reactiveoxygen species scavenging and alleviation of inflammation related diseases. Nat Commun 11:2788. https:\/\/doi.org\/10.1038\/s41467-020-16544-7","journal-title":"Nat Commun"},{"key":"3696_CR175","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ijbiomac.2020.12.183","volume":"170","author":"C Liu","year":"2021","unstructured":"Liu C, Yan Q, Gao C et al (2021) Study on antioxidant effect of recombinant glutathione peroxidase 1. Int J Biol Macromol 170:503\u2013513. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.12.183","journal-title":"Int J Biol Macromol"},{"issue":"24","key":"3696_CR176","doi-asserted-by":"publisher","first-page":"15893","DOI":"10.3390\/ijms232415893","volume":"23","author":"M Liu","year":"2022","unstructured":"Liu M, Sun X, Chen B et al (2022) Insights into manganese superoxide dismutase and human diseases. Int J Mol Sci 23(24):15893. https:\/\/doi.org\/10.3390\/ijms232415893","journal-title":"Int J Mol Sci"},{"key":"3696_CR177","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/cvr\/cvp092","volume":"82","author":"T Loch","year":"2009","unstructured":"Loch T, Vakhrusheva O, Piotrowska I et al (2009) Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice. Cardiovasc Res 82:448\u2013457. https:\/\/doi.org\/10.1093\/cvr\/cvp092","journal-title":"Cardiovasc Res"},{"key":"3696_CR178","doi-asserted-by":"publisher","unstructured":"Lopez JM, Zaghloul NM, Aysolla KR et al (2019) EC-SOD can prevent the chronic stages of pulmonary hypertension induced by hypoxia. Integr Mol Med 6:1\u20139. https:\/\/doi.org\/10.15761\/IMM.1000389","DOI":"10.15761\/IMM.1000389"},{"issue":"7","key":"3696_CR179","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1089\/ars.2010.3586","volume":"15","author":"E Lubos","year":"2011","unstructured":"Lubos E, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 15(7):1957\u20131997. https:\/\/doi.org\/10.1089\/ars.2010.3586","journal-title":"Antioxid Redox Signal"},{"key":"3696_CR180","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-405882-8.00001-5","volume":"527","author":"HS Marinho","year":"2013","unstructured":"Marinho HS, Cyrne L, Cadenas E, Antunes F (2013) The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol 527:3\u201319. https:\/\/doi.org\/10.1016\/B978-0-12-405882-8.00001-5","journal-title":"Methods Enzymol"},{"key":"3696_CR181","doi-asserted-by":"publisher","unstructured":"McCord JM, Fridovich I (1969) Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244(22):6049\u20136055. https:\/\/doi.org\/10.1016\/S0021-9258(18)63504-5","DOI":"10.1016\/S0021-9258(18)63504-5"},{"key":"3696_CR182","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13024-019-0329-1","volume":"14","author":"RM Meade","year":"2019","unstructured":"Meade RM, Fairlie DP, Mason JM (2019) Alpha-synuclein structure and Parkinson\u2019s disease\u2014lessons and emerging principles. Mol Neurodegeneration 14:29. https:\/\/doi.org\/10.1186\/s13024-019-0329-1","journal-title":"Mol Neurodegeneration"},{"issue":"6","key":"3696_CR183","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099286","volume":"9","author":"DA Mehaney","year":"2014","unstructured":"Mehaney DA, Darwish HA, Hegazy RA et al (2014) Analysis of oxidative stress status, catalase and catechol-O-methyltransferase polymorphisms in egyptian vitiligo patients. PLoS ONE 9(6):e99286. https:\/\/doi.org\/10.1371\/journal.pone.0099286","journal-title":"PLoS ONE"},{"issue":"9","key":"3696_CR184","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41570-021-00310-4","volume":"5","author":"D Meyerstein","year":"2021","unstructured":"Meyerstein D (2021) Re-examining fenton and fenton-like reactions. Nat Rev Chem 5(9):595\u2013597. https:\/\/doi.org\/10.1038\/s41570-021-00310-4","journal-title":"Nat Rev Chem"},{"issue":"6","key":"3696_CR185","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1684\/abc.2008.0283","volume":"66","author":"F Michel","year":"2008","unstructured":"Michel F, Bonnefont-Rousselot D, Mas E, Drai J, Th\u00e9rond P (2008) Biomarqueurs de la peroxydation lipidique: aspects analytiques [Biomarkers of lipid peroxidation: analytical aspects]. Ann Biol Clin (paris) 66(6):605\u2013620. https:\/\/doi.org\/10.1684\/abc.2008.0283","journal-title":"Ann Biol Clin (paris)"},{"issue":"1","key":"3696_CR186","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0167-4889(93)90091-3","volume":"1220","author":"E Middelkoop","year":"1993","unstructured":"Middelkoop E, Wiemer EA, Schoenmaker DE, Strijland A, Tager JM (1993) Topology of catalase assembly in human skin fibroblasts. Biochim Biophys Acta 1220(1):15\u201320. https:\/\/doi.org\/10.1016\/0167-4889(93)90091-3","journal-title":"Biochim Biophys Acta"},{"key":"3696_CR187","doi-asserted-by":"crossref","unstructured":"Milton NG (1999) Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown. Biochem J 344 Pt 2(Pt 2):293\u2013296.","DOI":"10.1042\/bj3440293"},{"issue":"4","key":"3696_CR188","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/iub.2008","volume":"71","author":"T Miyazawa","year":"2019","unstructured":"Miyazawa T, Burdeos GC, Itaya M et al (2019) Vitamin E: regulatory redox interactions. IUBMB Life 71(4):430\u2013441. https:\/\/doi.org\/10.1002\/iub.2008","journal-title":"IUBMB Life"},{"key":"3696_CR189","doi-asserted-by":"publisher","unstructured":"Moertel CG, Fleming TR, Creagan ET et al (1985) Rubin J, O'Connell MJ, Ames MM. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 312(3):137\u2013141. https:\/\/doi.org\/10.1056\/NEJM198501173120301","DOI":"10.1056\/NEJM198501173120301"},{"issue":"2","key":"3696_CR190","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.tiv.2005.06.048","volume":"20","author":"YJ Moon","year":"2006","unstructured":"Moon YJ, Wang X, Morris ME (2006) Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol in Vitro 20(2):187\u2013210. https:\/\/doi.org\/10.1016\/j.tiv.2005.06.048","journal-title":"Toxicol in Vitro"},{"key":"3696_CR191","doi-asserted-by":"publisher","unstructured":"Moreno D, Palopoli C, Daier V et al (2006) Synthesis, structure and catalase-like activity of dimanganese(III) complexes of 1,5-bis(X-salicylidenamino)pentan-3-ol (X = 3- and 5-methyl). Influence of phenyl-ring substituents on catalytic activity. Dalton Trans 5156\u201366. https:\/\/doi.org\/10.1039\/b609366c","DOI":"10.1039\/b609366c"},{"issue":"3","key":"3696_CR192","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1177\/1559827612460499","volume":"7","author":"PA Morganroth","year":"2013","unstructured":"Morganroth PA, Lim HW, Burnett CT (2013) Ultraviolet radiation and the skin: an in-depth review. Am J Lifestyle Med 7(3):168\u2013181. https:\/\/doi.org\/10.1177\/1559827612460499","journal-title":"Am J Lifestyle Med"},{"issue":"19","key":"3696_CR193","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1039\/c2cc17013b","volume":"48","author":"J Mu","year":"2012","unstructured":"Mu J, Wang Y, Zhao M, Zhang L (2012) Intrinsic peroxidase-like activity and catalase-like activity of Co3O4 nanoparticles. Chem Commun (camb) 48(19):2540\u20132542. https:\/\/doi.org\/10.1039\/c2cc17013b","journal-title":"Chem Commun (camb)"},{"issue":"12","key":"3696_CR194","doi-asserted-by":"publisher","first-page":"4973","DOI":"10.1182\/blood.V90.12.4973","volume":"90","author":"S Mueller","year":"1997","unstructured":"Mueller S, Riedel HD, Stremmel W (1997) Direct evidence for catalase as the predominant H2O2 -removing enzyme in human erythrocytes. Blood 90(12):4973\u20134278. https:\/\/doi.org\/10.1182\/blood.V90.12.4973","journal-title":"Blood"},{"key":"3696_CR195","doi-asserted-by":"publisher","unstructured":"Nakamura Y, Feng Q, Kumagai T et al (2002) Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J Biol Chem 277(4):2687\u20132694. https:\/\/doi.org\/10.1074\/jbc.M109641200","DOI":"10.1074\/jbc.M109641200"},{"key":"3696_CR196","doi-asserted-by":"publisher","first-page":"9613090","DOI":"10.1155\/2019\/9613090","volume":"2019","author":"A Nandi","year":"2019","unstructured":"Nandi A, Yan LJ, Jana CK, Das N (2019) Role of catalase in oxidative stress- and age-associated degenerative diseases. Oxid Med Cell Longev 2019:9613090. https:\/\/doi.org\/10.1155\/2019\/9613090","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"3696_CR197","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/antiox7070089","volume":"7","author":"G Nauman","year":"2018","unstructured":"Nauman G, Gray JC, Parkinson R et al (2018) Systematic review of intravenous ascorbate in cancer clinical trials. Antioxidants (basel) 7(7):89. https:\/\/doi.org\/10.3390\/antiox7070089","journal-title":"Antioxidants (basel)"},{"key":"3696_CR198","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/2212796810903010022","volume":"3","author":"MT Nechifor","year":"2009","unstructured":"Nechifor MT, Neagu TM, Manda G (2009) Reactive oxygen species, cancer and anti-cancer therapies. Curr Chem Biol 3:22\u201346. https:\/\/doi.org\/10.2174\/2212796810903010022","journal-title":"Curr Chem Biol"},{"issue":"3","key":"3696_CR199","doi-asserted-by":"publisher","first-page":"L422","DOI":"10.1152\/ajplung.90293.2008","volume":"295","author":"E Nozik-Grayck","year":"2008","unstructured":"Nozik-Grayck E, Suliman HB, Majka S et al (2008) Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol 295(3):L422\u2013L4230. https:\/\/doi.org\/10.1152\/ajplung.90293.2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"3696_CR200","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3945\/jn.108.095182","volume":"139","author":"E Nurk","year":"2009","unstructured":"Nurk E, Refsum H, Drevon CA et al (2009) Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J Nutr 139(1):120\u2013127. https:\/\/doi.org\/10.3945\/jn.108.095182","journal-title":"J Nutr"},{"issue":"4","key":"3696_CR201","first-page":"1141","volume":"39","author":"LW Oberley","year":"1979","unstructured":"Oberley LW, Buettner GR (1979) Role of superoxide dismutase in cancer: a review. Cancer Res 39(4):1141\u20131149","journal-title":"Cancer Res"},{"issue":"1","key":"3696_CR202","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/jnci\/djr475","volume":"104","author":"NJ Ollberding","year":"2012","unstructured":"Ollberding NJ, Lim U, Wilkens LR et al (2012) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study. J Natl Cancer Inst 104(1):67\u201376. https:\/\/doi.org\/10.1093\/jnci\/djr475","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"3696_CR203","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1253\/circj.72.1","volume":"72","author":"FG Ottaviano","year":"2008","unstructured":"Ottaviano FG, Handy DE, Loscalzo J (2008) Redox regulation in the extracellular environment. Circ J 72(1):1\u201316. https:\/\/doi.org\/10.1253\/circj.72.1","journal-title":"Circ J"},{"issue":"6","key":"3696_CR204","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/odi.12446","volume":"22","author":"SJ Padayatty","year":"2016","unstructured":"Padayatty SJ, Levine M (2016) Vitamin C: the known and the unknown and Goldilocks. Oral Dis 22(6):463\u2013493. https:\/\/doi.org\/10.1111\/odi.12446","journal-title":"Oral Dis"},{"issue":"1","key":"3696_CR205","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/cmi.2014.89","volume":"12","author":"A Panday","year":"2015","unstructured":"Panday A, Sahoo MK, Osorio D, Batra S (2015) NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol 12(1):5\u201323. https:\/\/doi.org\/10.1038\/cmi.2014.89","journal-title":"Cell Mol Immunol"},{"key":"3696_CR206","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0162-0134(00)80022-7","volume":"11","author":"RF Pasternack","year":"1979","unstructured":"Pasternack RF, Skowronek WR (1979) Catalysis of the disproportionation of superoxide by metalloporphyrins. J Inorg Biochem 11:261\u2013267. https:\/\/doi.org\/10.1016\/S0162-0134(00)80022-7","journal-title":"J Inorg Biochem"},{"key":"3696_CR207","doi-asserted-by":"publisher","first-page":"1147414","DOI":"10.3389\/fphar.2023.1147414","volume":"14","author":"J Pei","year":"2023","unstructured":"Pei J, Pan X, Wei G, Hua Y (2023) Research progress of glutathione peroxidase family (GPX) in redoxidation. Front Pharmacol 14:1147414. https:\/\/doi.org\/10.3389\/fphar.2023.1147414","journal-title":"Front Pharmacol"},{"issue":"10","key":"3696_CR208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046214","volume":"7","author":"DF Peng","year":"2012","unstructured":"Peng DF, Hu TL, Schneider BG et al (2012) Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS ONE 7(10):e46214. https:\/\/doi.org\/10.1371\/journal.pone.0046214","journal-title":"PLoS ONE"},{"issue":"6","key":"3696_CR209","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1096\/fba.2022-00045","volume":"5","author":"F Peng","year":"2023","unstructured":"Peng F, Xu Q, Jing X et al (2023) GPX2 promotes EMT and metastasis in non-small cell lung cancer by activating PI3K\/AKT\/mTOR\/Snail signaling axis. FASEB Bioadv 5(6):233\u2013250. https:\/\/doi.org\/10.1096\/fba.2022-00045","journal-title":"FASEB Bioadv"},{"key":"3696_CR210","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbapap.2009.11.004","volume":"2","author":"JJ Perry","year":"1804","unstructured":"Perry JJ, Shin DS, Getzoff ED et al (1804) (2010) The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta 2:245\u2013262. https:\/\/doi.org\/10.1016\/j.bbapap.2009.11.004","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"3696_CR211","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1021\/np9904509","volume":"63","author":"PG Pietta","year":"2000","unstructured":"Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63(7):1035\u20131042. https:\/\/doi.org\/10.1021\/np9904509","journal-title":"J Nat Prod"},{"issue":"7","key":"3696_CR212","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.tips.2017.04.005","volume":"38","author":"P Poprac","year":"2017","unstructured":"Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M (2017) Targeting free radicals in oxidative stress-related human diseases. Trends Pharmacol Sci 38(7):592\u2013607. https:\/\/doi.org\/10.1016\/j.tips.2017.04.005","journal-title":"Trends Pharmacol Sci"},{"key":"3696_CR213","doi-asserted-by":"publisher","unstructured":"Prasad N, Ramteke P, Dholia N, Yadav UCS, Chapter 27 - Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies, Editor(s): Shampa Chatterjee, Wolfgang Jungraithmayr, Debasis Bagchi, Immunity and Inflammation in Health and Disease, Academic Press, 2018, pp 341\u2013362. https:\/\/doi.org\/10.1016\/B978-0-12-805417-8.00027-5","DOI":"10.1016\/B978-0-12-805417-8.00027-5"},{"issue":"4","key":"3696_CR214","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","volume":"82","author":"D Prochazkova","year":"2011","unstructured":"Prochazkova D, Bousova I, Wilhelmova N (2011) Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82(4):513\u2013523. https:\/\/doi.org\/10.1016\/j.fitote.2011.01.018","journal-title":"Fitoterapia"},{"key":"3696_CR215","doi-asserted-by":"crossref","unstructured":"Pryor WA, In Natural Antioxidants in Human Health and Disease; Frei, B., Ed.; Academic Press: New York, 1994; pp 1\u201324.","DOI":"10.1016\/B978-0-08-057168-3.50007-2"},{"issue":"2\u20133","key":"3696_CR216","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00775-016-1415-2","volume":"22","author":"DA Quist","year":"2017","unstructured":"Quist DA, Diaz DE, Liu JJ, Karlin KD (2017) Activation of dioxygen by copper metalloproteins and insights from model complexes. J Biol Inorg Chem 22(2\u20133):253\u2013288. https:\/\/doi.org\/10.1007\/s00775-016-1415-2","journal-title":"J Biol Inorg Chem"},{"issue":"2","key":"3696_CR217","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1007\/s10620-006-9177-2","volume":"52","author":"T Rainis","year":"2007","unstructured":"Rainis T, Maor I, Lanir A, Shnizer S, Lavy A (2007) Enhanced oxidative stress and leucocyte activation in neoplastic tissues of the colon. Dig Dis Sci 52(2):526\u2013530. https:\/\/doi.org\/10.1007\/s10620-006-9177-2","journal-title":"Dig Dis Sci"},{"key":"3696_CR218","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/180906","volume":"2013","author":"T Ramming","year":"2013","unstructured":"Ramming T, Appenzeller-Herzog C (2013) Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulum. Int J Cell Biol 2013:180906. https:\/\/doi.org\/10.1155\/2013\/180906","journal-title":"Int J Cell Biol"},{"key":"3696_CR219","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.biomaterials.2016.03.036","volume":"93","author":"C Ren","year":"2016","unstructured":"Ren C, Hu X, Li X, Zhou Q (2016) Ultra-trace graphene oxide in a water environment triggers Parkinson\u2019s disease-like symptoms and metabolic disturbance in zebrafish larvae. Biomaterials 93:83\u201394. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.03.036","journal-title":"Biomaterials"},{"issue":"5","key":"3696_CR220","doi-asserted-by":"publisher","first-page":"1700595","DOI":"10.1002\/advs.201700595","volume":"5","author":"C Ren","year":"2018","unstructured":"Ren C, Hu X, Zhou Q (2018) Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase-Like Activity and Metabolic Regulation. Adv Sci (weinh) 5(5):1700595. https:\/\/doi.org\/10.1002\/advs.201700595","journal-title":"Adv Sci (weinh)"},{"key":"3696_CR221","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119752","volume":"232","author":"C Ren","year":"2020","unstructured":"Ren C, Li D, Zhou Q, Hu X (2020) Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1\/M2 microglial polarization in an Alzheimer\u2019s disease model. Biomaterials 232:119752. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119752","journal-title":"Biomaterials"},{"key":"3696_CR222","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12951-022-01295-y","volume":"20","author":"X Ren","year":"2022","unstructured":"Ren X, Chen D, Wang Y et al (2022a) Nanozymes-recent development and biomedical applications. J Nanobiotechnol 20:92. https:\/\/doi.org\/10.1186\/s12951-022-01295-y","journal-title":"J Nanobiotechnol"},{"issue":"8","key":"3696_CR223","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107266119","volume":"119","author":"Z Ren","year":"2022","unstructured":"Ren Z, Liang H, Galbo PM Jr et al (2022b) Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer. Proc Natl Acad Sci U S A 119(8):e2107266119. https:\/\/doi.org\/10.1073\/pnas.2107266119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3696_CR224","doi-asserted-by":"publisher","first-page":"182","DOI":"10.4103\/0971-6203.189482","volume":"41","author":"A Rezaeyan","year":"2016","unstructured":"Rezaeyan A, Haddadi G, Hosseinzadeh M et al (2016) Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue. J Med Phys 41:182. https:\/\/doi.org\/10.4103\/0971-6203.189482","journal-title":"J Med Phys"},{"issue":"1","key":"3696_CR225","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1093\/ajcn\/77.1.133","volume":"77","author":"TH Rissanen","year":"2023","unstructured":"Rissanen TH, Voutilainen S, Nyyss\u00f6nen K (2023) Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 77(1):133\u2013138. https:\/\/doi.org\/10.1093\/ajcn\/77.1.133","journal-title":"Am J Clin Nutr"},{"key":"3696_CR226","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1016\/j.bbagen.2014.05.017","volume":"9","author":"L Rochette","year":"1840","unstructured":"Rochette L, Zeller M, Cottin Y (1840) Vergely C (2014) Diabetes, oxidative stress and therapeutic strategies. Biochim Biophys Acta 9:2709\u20132729. https:\/\/doi.org\/10.1016\/j.bbagen.2014.05.017","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"3696_CR227","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1080\/21551197.2012.702534","volume":"31","author":"DF Romagnolo","year":"2012","unstructured":"Romagnolo DF, Selmin OI (2012) Flavonoids and cancer prevention: a review of the evidence. J Nutr Gerontol Geriatr 31(3):206\u2013238. https:\/\/doi.org\/10.1080\/21551197.2012.702534","journal-title":"J Nutr Gerontol Geriatr"},{"key":"3696_CR228","doi-asserted-by":"publisher","unstructured":"Rossato MF, Hoffmeister C, Tonello et al (2015) Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats. Inflammation. 2015;38(2):606\u2013615. https:\/\/doi.org\/10.1007\/s10753-014-9967-1","DOI":"10.1007\/s10753-014-9967-1"},{"key":"3696_CR229","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3390\/antiox11010040","volume":"11","author":"U Samuni","year":"2022","unstructured":"Samuni U, Samuni A, Goldstein S (2022) Cyclic hydroxylaminesas monitors of peroxynitrite and superoxide-revisited. Antioxidants 11:40. https:\/\/doi.org\/10.3390\/antiox11010040","journal-title":"Antioxidants"},{"issue":"11","key":"3696_CR230","doi-asserted-by":"publisher","first-page":"5177","DOI":"10.1021\/jacs.9b12873","volume":"142","author":"Y Sang","year":"2020","unstructured":"Sang Y, Cao F, Li W et al (2020) Bioinspired construction of a nanozyme-based H2O2 homeostasis disruptor for intensive chemodynamic therapy. J Am Chem Soc 142(11):5177\u20135183. https:\/\/doi.org\/10.1021\/jacs.9b12873","journal-title":"J Am Chem Soc"},{"key":"3696_CR231","doi-asserted-by":"publisher","unstructured":"Sansone R, Rodriguez-Mateos A, Heuel J et al (2015) Flaviola Consortium, European Union 7th Framework Program. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Br J Nutr 114(8):1246\u20131255. https:\/\/doi.org\/10.1017\/S0007114515002822","DOI":"10.1017\/S0007114515002822"},{"key":"3696_CR232","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1017\/10.1016\/j.cbi.2015.07.014","volume":"242","author":"BL Santos","year":"2015","unstructured":"Santos BL, Oliveira MN, Coelho PL et al (2015) Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression. Chem Biol Interact 242:123\u2013138. https:\/\/doi.org\/10.1017\/10.1016\/j.cbi.2015.07.014","journal-title":"Chem Biol Interact"},{"key":"3696_CR233","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/sj.jid.5700257","volume":"126","author":"KU Schallreuter","year":"2006","unstructured":"Schallreuter KU, Chiuchiarelli G, Cemeli E et al (2006) Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo. J Investig Dermatol 126:1036\u20131042. https:\/\/doi.org\/10.1038\/sj.jid.5700257","journal-title":"J Investig Dermatol"},{"issue":"4","key":"3696_CR234","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ccell.2017.02.018","volume":"31","author":"JD Schoenfeld","year":"2017","unstructured":"Schoenfeld JD, Sibenaller ZA, Mapuskar KA et al (2017) O2\u22c5- and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell 31(4):487-500.e8. https:\/\/doi.org\/10.1016\/j.ccell.2017.02.018","journal-title":"Cancer Cell"},{"key":"3696_CR235","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/antiox7010010","volume":"7","author":"M Schubert","year":"2018","unstructured":"Schubert M, Kluge S, Schm\u00f6lz L, Wallert M, Galli F et al (2018) Long-chain metabolites of vitamin E: Metabolic activation as a general concept for lipid-soluble vitamins? Antioxidants 7:10. https:\/\/doi.org\/10.3390\/antiox7010010","journal-title":"Antioxidants"},{"key":"3696_CR236","doi-asserted-by":"publisher","first-page":"9858","DOI":"10.1039\/C1DT10862J","volume":"40","author":"K Selvakumar","year":"2011","unstructured":"Selvakumar K, Singh HB, Goel N, Singh UP, Butcher RJ (2011) Synthesis and structural characterization of pincer type bicyclic diacyloxy- and diazaselenuranes. Dalton Trans 40:9858\u20139867. https:\/\/doi.org\/10.1039\/C1DT10862J","journal-title":"Dalton Trans"},{"key":"3696_CR237","doi-asserted-by":"publisher","unstructured":"Sharma VK, Graham NJD (2010) Oxidation of amino acids, peptides and proteins by ozone: a review. ozone: science & engineering, 32:81\u201390, https:\/\/doi.org\/10.1080\/01919510903510507","DOI":"10.1080\/01919510903510507"},{"issue":"1","key":"3696_CR238","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1073\/pnas.1417231112","volume":"112","author":"R Shema","year":"2015","unstructured":"Shema R, Kulicke R, Cowley GS et al (2015) Synthetic lethal screening in the mammalian central nervous system identifies Gpx6 as a modulator of Huntington\u2019s disease. Proc Natl Acad Sci U S A 112(1):268\u2013272. https:\/\/doi.org\/10.1073\/pnas.1417231112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3696_CR239","doi-asserted-by":"publisher","first-page":"7417","DOI":"10.1038\/s41598-021-86477-8","volume":"11","author":"J Shen","year":"2021","unstructured":"Shen J, Griffiths PT, Campbell SJ et al (2021) Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants. Sci Rep 11:7417. https:\/\/doi.org\/10.1038\/s41598-021-86477-8","journal-title":"Sci Rep"},{"key":"3696_CR240","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.acr.2017.08.002","volume":"136","author":"SP Short","year":"2017","unstructured":"Short SP, Williams CS (2017) Selenoproteins in Tumorigenesis and Cancer Progression. Adv Cancer Res 136:49\u201383. https:\/\/doi.org\/10.1016\/bs.acr.2017.08.002","journal-title":"Adv Cancer Res"},{"issue":"15","key":"3696_CR241","doi-asserted-by":"publisher","first-page":"4230","DOI":"10.1002\/chem.200601209","volume":"13","author":"W Sicking","year":"2007","unstructured":"Sicking W, Korth HG, Jansen G, de Groot H, Sustmann R (2007) Hydrogen peroxide decomposition by a non-heme iron(III) catalase mimic: a DFT study. Chemistry 13(15):4230\u20134245. https:\/\/doi.org\/10.1002\/chem.200601209","journal-title":"Chemistry"},{"key":"3696_CR242","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/anie.198610581","volume":"25","author":"H Sies","year":"1986","unstructured":"Sies H (1986) Biochemistry of oxidative stress. Ang Chem Int Ed Engl 25:1058\u20131071. https:\/\/doi.org\/10.1002\/anie.198610581","journal-title":"Ang Chem Int Ed Engl"},{"issue":"3","key":"3696_CR243","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0891-5849(93)90028-s","volume":"14","author":"H Sies","year":"1993","unstructured":"Sies H (1993) Ebselen, a selenoorganic compound as glutathione peroxidase mimic. Free Radic Biol Med 14(3):313\u2013323. https:\/\/doi.org\/10.1016\/0891-5849(93)90028-s","journal-title":"Free Radic Biol Med"},{"key":"3696_CR244","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","volume":"11","author":"H Sies","year":"2017","unstructured":"Sies H (2017) Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol 11:613\u2013619. https:\/\/doi.org\/10.1016\/j.redox.2016.12.035","journal-title":"Redox Biol"},{"issue":"8","key":"3696_CR245","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1007\/s11427-023-2336-1","volume":"66","author":"H Sies","year":"2023","unstructured":"Sies H (2023) Oxidative eustress: the physiological role of oxidants. Sci China Life Sci 66(8):1947\u20131948. https:\/\/doi.org\/10.1007\/s11427-023-2336-1","journal-title":"Sci China Life Sci"},{"issue":"7","key":"3696_CR246","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21(7):363\u2013383. https:\/\/doi.org\/10.1038\/s41580-020-0230-3","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"3696_CR247","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41580-022-00456-z","volume":"23","author":"H Sies","year":"2022","unstructured":"Sies H, Belousov VV, Chandel NS et al (2022) Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat Rev Mol Cell Biol 23(7):499\u2013515. https:\/\/doi.org\/10.1038\/s41580-022-00456-z","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"3696_CR248","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00204-019-02538-y","volume":"93","author":"M Simunkova","year":"2019","unstructured":"Simunkova M, Alwasel SH, Alhazza IM, Jomova K, Kollar V, Rusko M, Valko M (2019) Management of oxidative stress and other pathologies in Alzheimer\u2019s disease. Arch Toxicol 93(9):2491\u20132513. https:\/\/doi.org\/10.1007\/s00204-019-02538-y","journal-title":"Arch Toxicol"},{"issue":"6","key":"3696_CR249","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1002\/anie.202011711","volume":"60","author":"N Singh","year":"2021","unstructured":"Singh N, NaveenKumar SK, Geethika M, Mugesh G (2021) A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells. Angew Chem Int Ed Engl 60(6):3121\u20133130. https:\/\/doi.org\/10.1002\/anie.202011711","journal-title":"Angew Chem Int Ed Engl"},{"issue":"33","key":"3696_CR250","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202301232","volume":"62","author":"N Singh","year":"2023","unstructured":"Singh N, Sherin GR, Mugesh F (2023) Antioxidant and prooxidant nanozymes: from cellular redox regulation to next-generation therapeutics. Angew Chem Int Ed Engl 62(33):e202301232. https:\/\/doi.org\/10.1002\/anie.202301232","journal-title":"Angew Chem Int Ed Engl"},{"key":"3696_CR251","doi-asserted-by":"publisher","unstructured":"Singh N, Mugesh G. CeVO4 Nanozymes Catalyze the Reduction of Dioxygen to Water without Releasing Partially Reduced Oxygen Species. Angew Chem Int Ed Engl 58(23):7797\u20137801. https:\/\/doi.org\/10.1002\/anie.201903427","DOI":"10.1002\/anie.201903427"},{"key":"3696_CR252","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102109","volume":"46","author":"AG Siraki","year":"2021","unstructured":"Siraki AG (2021) The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery. Redox Biol 46:102109. https:\/\/doi.org\/10.1016\/j.redox.2021.102109","journal-title":"Redox Biol"},{"issue":"10 Pt 2","key":"3696_CR253","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1016\/j.neubiorev.2013.06.013","volume":"37","author":"AN Sokolov","year":"2013","unstructured":"Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P (2013) Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior. Neurosci Biobehav Rev 37(10 Pt 2):2445\u20132453. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.06.013","journal-title":"Neurosci Biobehav Rev"},{"key":"3696_CR254","first-page":"83","volume-title":"Diversity of Selenium Functions in Health and Disease","author":"JE Spallholz","year":"2016","unstructured":"Spallholz JE (2016) Redox cycling and the toxicity of selenium compunds. In: Brigelius-Floh\u00e9 RSies H, (ed) Diversity of Selenium Functions in Health and Disease. CRC Press, Boca Raton, FL, pp 83\u2013108"},{"issue":"37","key":"3696_CR255","doi-asserted-by":"publisher","first-page":"34783","DOI":"10.1074\/jbc.M305063200","volume":"278","author":"JP Spencer","year":"2003","unstructured":"Spencer JP, Rice-Evans C, Williams RJ (2003) Modulation of pro-survival Akt\/protein kinase B and ERK1\/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J Biol Chem 278(37):34783\u201334793. https:\/\/doi.org\/10.1074\/jbc.M305063200","journal-title":"J Biol Chem"},{"issue":"13","key":"3696_CR256","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1074\/jbc.RA118.006219","volume":"294","author":"JS Stancill","year":"2019","unstructured":"Stancill JS, Broniowska KA, Oleson BJ, Naatz A, Corbett JA (2019) Pancreatic \u03b2-cells detoxify H2O2 through the peroxiredoxin\/thioredoxin antioxidant system. J Biol Chem 294(13):4843\u20134853. https:\/\/doi.org\/10.1074\/jbc.RA118.006219","journal-title":"J Biol Chem"},{"issue":"2","key":"3696_CR257","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1753-4887.2005.tb00122.x","volume":"63","author":"JM Stringham","year":"2005","unstructured":"Stringham JM, Hammond BR Jr (2005) Dietary lutein and zeaxanthin: possible effects on visual function. Nutr Rev 63(2):59\u201364. https:\/\/doi.org\/10.1111\/j.1753-4887.2005.tb00122.x","journal-title":"Nutr Rev"},{"key":"3696_CR258","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0021-9258(18)74274-9","volume":"121","author":"JB Sumner","year":"1937","unstructured":"Sumner JB, Dounce AB (1937) Crystalline catalase. J Biochem 121:417\u2013424. https:\/\/doi.org\/10.1016\/S0021-9258(18)74274-9","journal-title":"J Biochem"},{"issue":"6","key":"3696_CR259","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/1440-1681.12412","volume":"42","author":"LC Sung","year":"2015","unstructured":"Sung LC, Chao HH, Chen CH et al (2015) Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol 42(6):632\u2013639. https:\/\/doi.org\/10.1111\/1440-1681.12412","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1\u20132","key":"3696_CR260","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/0014-5793(96)00087-7","volume":"381","author":"C Szab\u00f3","year":"1996","unstructured":"Szab\u00f3 C, Day BJ, Salzman AL (1996) Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett 381(1\u20132):82\u201386. https:\/\/doi.org\/10.1016\/0014-5793(96)00087-7","journal-title":"FEBS Lett"},{"issue":"9","key":"3696_CR261","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1093\/humrep\/det237","volume":"28","author":"A Taylor","year":"2013","unstructured":"Taylor A, Robson A, Houghton BC, Jepson CA, Ford WC, Frayne J (2013) Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation. Hum Reprod 28(9):2332\u20132342. https:\/\/doi.org\/10.1093\/humrep\/det237","journal-title":"Hum Reprod"},{"issue":"6","key":"3696_CR262","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1093\/advances\/nmaa069","volume":"11","author":"AC Tierney","year":"2020","unstructured":"Tierney AC, Rumble CE, Billings LM, George ES (2020) Effect of dietary and supplemental lycopene on cardiovascular risk factors: a systematic review and meta-analysis. Adv Nutr 11(6):1453\u20131488. https:\/\/doi.org\/10.1093\/advances\/nmaa069","journal-title":"Adv Nutr"},{"issue":"5","key":"3696_CR263","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1113\/EP086204","volume":"104","author":"RM Touyz","year":"2019","unstructured":"Touyz RM, Anagnostopoulou A, Rios F et al (2019) NOX5: Molecular biology and pathophysiology. Exp Physiol 104(5):605\u2013616. https:\/\/doi.org\/10.1113\/EP086204","journal-title":"Exp Physiol"},{"issue":"11","key":"3696_CR264","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/j.1753-4887.2008.00123.x","volume":"66","author":"MG Traber","year":"2008","unstructured":"Traber MG (2008) Vitamin E and K interactions\u2013a 50-year-old problem. Nutr Rev 66(11):624\u2013629. https:\/\/doi.org\/10.1111\/j.1753-4887.2008.00123.x","journal-title":"Nutr Rev"},{"key":"3696_CR265","first-page":"293","volume-title":"Modern nutrition in health and disease","author":"MG Traber","year":"2014","unstructured":"Traber MG, Vitamin E (2014). In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR (eds) Modern nutrition in health and disease, 11th edn. Lippincott Williams & Wilkins, Philadelphia, pp 293\u2013304","edition":"11"},{"key":"3696_CR266","unstructured":"Traber MG (2023) Vitamin E, Linus Pauling Institute, Oregon State university, https:\/\/lpi.oregonstate.edu\/mic\/vitamins\/vitamin-E#reference29"},{"issue":"2","key":"3696_CR267","first-page":"153","volume":"15","author":"N Tran","year":"2022","unstructured":"Tran N, Garcia T, Aniqa M (2022) Endothelial nitric oxide synthase (eNOS) and the cardiovascular system in physiology and in disease states. Am J Biomed Sci Res 15(2):153\u2013177","journal-title":"Am J Biomed Sci Res"},{"issue":"10","key":"3696_CR268","doi-asserted-by":"publisher","first-page":"8465","DOI":"10.3390\/ijms24108465","volume":"24","author":"V Travagli","year":"2003","unstructured":"Travagli V, Iorio EL (2003) The biological and molecular action of ozone and its derivatives: state-of-the-art, enhanced scenarios, and quality insights. Int J Mol Sci 24(10):8465. https:\/\/doi.org\/10.3390\/ijms24108465","journal-title":"Int J Mol Sci"},{"key":"3696_CR269","doi-asserted-by":"publisher","unstructured":"ABTC Trial (1994) Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330(15):1029\u20131035. https:\/\/doi.org\/10.1056\/NEJM199404143301501","DOI":"10.1056\/NEJM199404143301501"},{"issue":"17","key":"3696_CR270","doi-asserted-by":"publisher","first-page":"9215","DOI":"10.1002\/anie.202000451","volume":"60","author":"BG Trist","year":"2021","unstructured":"Trist BG, Hilton JB, Hare DJ (2021) Superoxide dismutase 1 in health and disease: How a frontline antioxidant becomes neurotoxic. Angew Chem Int Ed Engl 60(17):9215\u20139246. https:\/\/doi.org\/10.1002\/anie.202000451","journal-title":"Angew Chem Int Ed Engl"},{"issue":"7","key":"3696_CR271","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3390\/antiox11071374","volume":"11","author":"EE Tsermpini","year":"2022","unstructured":"Tsermpini EE, Plemenita\u0161 Ilje\u0161 A, Dol\u017ean V (2022) Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder: a systematic review. Antioxidants 11(7):1374. https:\/\/doi.org\/10.3390\/antiox11071374","journal-title":"Antioxidants"},{"issue":"10","key":"3696_CR272","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/s0891-5849(01)00513-5","volume":"30","author":"S Turnbull","year":"2001","unstructured":"Turnbull S, Tabner BJ, El-Agnaf OM (2001) Alpha-Synuclein implicated in Parkinson\u2019s disease catalyses the formation of hydrogen peroxide in vitro. Free Radic Biol Med 30(10):1163\u20131170. https:\/\/doi.org\/10.1016\/s0891-5849(01)00513-5","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"3696_CR273","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1042\/bj1910421","volume":"191","author":"JF Turrens","year":"1980","unstructured":"Turrens JF, Boveris A (1980) Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 191(2):421\u2013427. https:\/\/doi.org\/10.1042\/bj1910421","journal-title":"Biochem J"},{"issue":"1\u20132","key":"3696_CR274","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1023\/b:mcbi.0000049134.69131.89","volume":"266","author":"M Valko","year":"2004","unstructured":"Valko M, Izakovic M, Mazur M (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266(1\u20132):37\u201356. https:\/\/doi.org\/10.1023\/b:mcbi.0000049134.69131.89","journal-title":"Mol Cell Biochem"},{"issue":"10","key":"3696_CR275","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.2174\/0929867053764635","volume":"12","author":"M Valko","year":"2005","unstructured":"Valko M, Morris H, Cronin MT (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12(10):1161\u20131208. https:\/\/doi.org\/10.2174\/0929867053764635","journal-title":"Curr Med Chem"},{"issue":"1","key":"3696_CR276","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1):44\u201384. https:\/\/doi.org\/10.1016\/j.biocel.2006.07.001","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"3696_CR277","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","volume":"90","author":"M Valko","year":"2016","unstructured":"Valko M, Jomova K, Rhodes CJ (2016) Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol 90(1):1\u201337. https:\/\/doi.org\/10.1007\/s00204-015-1579-5","journal-title":"Arch Toxicol"},{"issue":"3\u20134","key":"3696_CR278","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","volume":"3","author":"D Vauzour","year":"2008","unstructured":"Vauzour D, Vafeiadou K, Rodriguez-Mateos A (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3(3\u20134):115\u2013126. https:\/\/doi.org\/10.1007\/s12263-008-0091-4","journal-title":"Genes Nutr"},{"issue":"1","key":"3696_CR279","doi-asserted-by":"publisher","first-page":"258","DOI":"10.2741\/S25","volume":"1","author":"S Veeramachaneni","year":"2009","unstructured":"Veeramachaneni S, Wang XD (2009) Carotenoids and lung cancer prevention. Front Biosci (schol Ed) 1(1):258\u2013274. https:\/\/doi.org\/10.2741\/S25","journal-title":"Front Biosci (schol Ed)"},{"key":"3696_CR280","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111431","volume":"219","author":"A Vincent","year":"2021","unstructured":"Vincent A, Thauvin M, Qu\u00e9vrain E et al (2021) Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models. J Inorg Biochem 219:111431. https:\/\/doi.org\/10.1016\/j.jinorgbio.2021.111431","journal-title":"J Inorg Biochem"},{"key":"3696_CR281","doi-asserted-by":"publisher","unstructured":"Vinceti M, Filippini T, Del Giovane C et al (2018) Selenium for preventing cancer. Cochrane Database Syst Rev 1:Cd005195. https:\/\/doi.org\/10.1002\/14651858.CD005195","DOI":"10.1002\/14651858.CD005195"},{"issue":"2","key":"3696_CR282","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.febslet.2006.12.037","volume":"581","author":"J Vlasits","year":"2007","unstructured":"Vlasits J, Jakopitsch C, Schwanninger M (2007) Hydrogen peroxide oxidation by catalase-peroxidase follows a non-scrambling mechanism. FEBS Lett 581(2):320\u2013324. https:\/\/doi.org\/10.1016\/j.febslet.2006.12.037","journal-title":"FEBS Lett"},{"issue":"6","key":"3696_CR283","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/ajcn\/83.6.1265","volume":"83","author":"S Voutilainen","year":"2006","unstructured":"Voutilainen S, Nurmi T, Mursu J (2006) Carotenoids and cardiovascular health. Am J Clin Nutr 83(6):1265\u20131271. https:\/\/doi.org\/10.1093\/ajcn\/83.6.1265","journal-title":"Am J Clin Nutr"},{"key":"3696_CR284","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/09687680010000311","volume":"17","author":"X Wang","year":"2000","unstructured":"Wang X, Quinn PJ (2000) The location and function of vitamin E in membranes (Review). Mol Membr Biol 17:143\u2013156. https:\/\/doi.org\/10.1080\/09687680010000311","journal-title":"Mol Membr Biol"},{"issue":"1","key":"3696_CR285","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S000711451300278X","volume":"111","author":"X Wang","year":"2014","unstructured":"Wang X, Ouyang YY, Liu J (2014a) Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br J Nutr 111(1):1\u201311. https:\/\/doi.org\/10.1017\/S000711451300278X","journal-title":"Br J Nutr"},{"issue":"5","key":"3696_CR286","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.nut.2013.10.00","volume":"30","author":"ZM Wang","year":"2014","unstructured":"Wang ZM, Zhao D, Nie ZL (2014b) Flavonol intake and stroke risk: a meta-analysis of cohort studies. Nutrition 30(5):518\u2013523. https:\/\/doi.org\/10.1016\/j.nut.2013.10.00","journal-title":"Nutrition"},{"issue":"9","key":"3696_CR287","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137427","volume":"10","author":"Y Wang","year":"2015","unstructured":"Wang Y, Cui R, Xiao Y et al (2015) Effect of carotene and lycopene on the risk of prostate cancer: a systematic review and dose-response meta-analysis of observational studies. PLoS ONE 10(9):e0137427. https:\/\/doi.org\/10.1371\/journal.pone.0137427","journal-title":"PLoS ONE"},{"key":"3696_CR288","doi-asserted-by":"publisher","first-page":"6639","DOI":"10.2147\/OTT.S208781","volume":"12","author":"Y Wang","year":"2019","unstructured":"Wang Y, Cao P, Alshwmi M et al (2019a) GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the \u03b2-catenin-WNT pathway. Onco Targets Ther 12:6639\u20136651. https:\/\/doi.org\/10.2147\/OTT.S208781","journal-title":"Onco Targets Ther"},{"issue":"28","key":"3696_CR289","doi-asserted-by":"publisher","first-page":"13289","DOI":"10.1039\/c9nr03473k","volume":"11","author":"Z Wang","year":"2019","unstructured":"Wang Z, Shen X, Gao X (2019b) Simultaneous enzyme mimicking and chemical reduction mechanisms for nanoceria as a bio-antioxidant: a catalytic model bridging computations and experiments for nanozymes. Nanoscale 11(28):13289\u201313299. https:\/\/doi.org\/10.1039\/c9nr03473k","journal-title":"Nanoscale"},{"key":"3696_CR290","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100946","volume":"35","author":"X Wang","year":"2020","unstructured":"Wang X, Zhong X, Liu Z (2020) Recent progress of chemodynamic therapy-induced combination cancer therapy. NanoToday 35:100946. https:\/\/doi.org\/10.1016\/j.nantod.2020.100946","journal-title":"NanoToday"},{"key":"3696_CR291","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3390\/biomedicines10040891","volume":"10","author":"K Weaver","year":"2022","unstructured":"Weaver K, Skouta R (2022) The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities. Biomedicines 10:891. https:\/\/doi.org\/10.3390\/biomedicines10040891","journal-title":"Biomedicines"},{"key":"3696_CR292","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/s0891-5849(96)00526-6","volume":"23","author":"H Wei","year":"1997","unstructured":"Wei H, Cai Q, Rahn R (1997) Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-hydroxy-deoxyguanosine in DNA. Free Radic Biol Med 23:148\u2013154. https:\/\/doi.org\/10.1016\/s0891-5849(96)00526-6","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"3696_CR293","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.molcel.2012.10.007","volume":"48","author":"PC Wei","year":"2012","unstructured":"Wei PC, Hsieh YH, Su MI (2012a) Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell 48(5):747\u2013759. https:\/\/doi.org\/10.1016\/j.molcel.2012.10.007","journal-title":"Mol Cell"},{"issue":"7","key":"3696_CR294","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","volume":"36","author":"RJ Williams","year":"2004","unstructured":"Williams RJ, Spencer JP, Rice-Evans C (2004) Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36(7):838\u2013849. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2004.01.001","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"3696_CR295","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075604","volume":"8","author":"HD Woo","year":"2013","unstructured":"Woo HD, Kim J (2013a) Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PLoS ONE 8(9):e75604. https:\/\/doi.org\/10.1371\/journal.pone.0075604","journal-title":"PLoS ONE"},{"issue":"7","key":"3696_CR296","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3748\/wjg.v19.i7.1011","volume":"19","author":"HD Woo","year":"2013","unstructured":"Woo HD, Kim J (2013b) Dietary flavonoid intake and risk of stomach and colorectal cancer. World J Gastroenterol 19(7):1011\u20131019. https:\/\/doi.org\/10.3748\/wjg.v19.i7.1011","journal-title":"World J Gastroenterol"},{"issue":"1","key":"3696_CR297","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0304-4165(97)00006-8","volume":"1336","author":"AA Woodall","year":"1997","unstructured":"Woodall AA, Lee SW, Weesie RJ (1997) Oxidation of carotenoids by free radicals: relationship between structure and reactivity. Biochim Biophys Acta 1336(1):33\u201342. https:\/\/doi.org\/10.1016\/s0304-4165(97)00006-8","journal-title":"Biochim Biophys Acta"},{"key":"3696_CR298","unstructured":"Wu D, Cederbaum AI (2003) Alcohol, Oxidative Stress, and Free Radical Damage. Alcohol Res G=Health 27:277\u2013284"},{"issue":"33","key":"3696_CR299","doi-asserted-by":"publisher","DOI":"10.1016\/10.1002\/adma.202003563","volume":"32","author":"B Xu","year":"2020","unstructured":"Xu B, Cui Y, Wang W, Li S (2020) Immunomodulation-enhanced nanozyme-based tumor catalytic therapy. Adv Mater 32(33):e2003563. https:\/\/doi.org\/10.1016\/10.1002\/adma.202003563","journal-title":"Adv Mater"},{"key":"3696_CR300","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/acn3.38","volume":"1","author":"E Yakunin","year":"2014","unstructured":"Yakunin E, Kisos H, Kulik W et al (2014) The regulation of catalase activity by PPAR \u03b3 is affected by \u03b1-synuclein. Ann Clin Trans Neurol 1:145\u2013159. https:\/\/doi.org\/10.1002\/acn3.38","journal-title":"Ann Clin Trans Neurol"},{"issue":"9","key":"3696_CR301","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1089\/ars.2016.6866","volume":"27","author":"ED Yoboue","year":"2017","unstructured":"Yoboue ED, Rimessi A, Anelli T et al (2017) (2017) Regulation of calcium fluxes by GPX8, a Type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane. Antioxid Redox Signal 27(9):583\u2013595. https:\/\/doi.org\/10.1089\/ars.2016.6866","journal-title":"Antioxid Redox Signal"},{"issue":"17","key":"3696_CR302","doi-asserted-by":"publisher","first-page":"8043","DOI":"10.1158\/0008-5472.CAN-07-0648","volume":"67","author":"YP Yu","year":"2007","unstructured":"Yu YP, Yu G, Tseng G et al (2007) Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res 67(17):8043\u20138050. https:\/\/doi.org\/10.1158\/0008-5472.CAN-07-0648","journal-title":"Cancer Res"},{"issue":"6266","key":"3696_CR303","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1126\/science.aaa5004","volume":"350","author":"J Yun","year":"2015","unstructured":"Yun J, Mullarky E, Lu C, a, (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 350(6266):1391\u20131396. https:\/\/doi.org\/10.1126\/science.aaa5004","journal-title":"Science"},{"key":"3696_CR304","doi-asserted-by":"publisher","unstructured":"Zamora-Ros R, Forouhi NG, Sharp SJ et al (2013) The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. Diabetes Care 36(12):3961\u20133970. https:\/\/doi.org\/10.2337\/dc13-0877","DOI":"10.2337\/dc13-0877"},{"issue":"12","key":"3696_CR305","doi-asserted-by":"publisher","first-page":"8887","DOI":"10.1021\/acs.nanolett.9b03774","volume":"19","author":"S Zhao","year":"2019","unstructured":"Zhao S, Duan H, Yang Y et al (2019) Fenozyme protects the integrity of the blood-brain barrier against experimental cerebral malaria. Nano Lett 19(12):8887\u20138895. https:\/\/doi.org\/10.1021\/acs.nanolett.9b03774","journal-title":"Nano Lett"},{"key":"3696_CR306","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s12943-022-01616-7","volume":"21","author":"H Zhao","year":"2022","unstructured":"Zhao H, Ming T, Tang S et al (2022) Wnt signaling in colorectal cancer: pathogenic role and therapeutic target. Mol Cancer 21:144. https:\/\/doi.org\/10.1186\/s12943-022-01616-7","journal-title":"Mol Cancer"},{"issue":"10","key":"3696_CR307","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1021\/acs.chemrestox.0c00348","volume":"33","author":"A Zhitkovich","year":"2020","unstructured":"Zhitkovich A (2020) Nuclear and cytoplasmic functions of vitamin C. Chem Res Toxicol 33(10):2515\u20132526. https:\/\/doi.org\/10.1021\/acs.chemrestox.0c00348","journal-title":"Chem Res Toxicol"},{"issue":"9","key":"3696_CR308","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.numecd.2012.06.005","volume":"23","author":"Y Zhu","year":"2013","unstructured":"Zhu Y, Ling W, Guo H et al (2013) Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metab Cardiovasc Dis 23(9):843\u2013849. https:\/\/doi.org\/10.1016\/j.numecd.2012.06.005","journal-title":"Nutr Metab Cardiovasc Dis"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03696-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03696-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03696-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T04:15:36Z","timestamp":1722917736000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03696-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":308,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["3696"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03696-4","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"1 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third-party materials in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licensce and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Rights and permissions"}}]}}