{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:47:09Z","timestamp":1770821229046,"version":"3.50.1"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK102142"],"award-info":[{"award-number":["DK102142"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK125465"],"award-info":[{"award-number":["DK125465"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Toxicol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00204-024-03725-2","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T06:02:12Z","timestamp":1711692132000},"page":"1843-1858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice"],"prefix":"10.1007","volume":"98","author":[{"given":"Olamide B.","family":"Adelusi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jephte Y.","family":"Akakpo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Eichenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ejaz","family":"Sadaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anup","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-6980","authenticated-orcid":false,"given":"Hartmut","family":"Jaeschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"3725_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116043","volume":"445","author":"OB Adelusi","year":"2022","unstructured":"Adelusi OB, Ramachandran A, Lemasters JJ, Jaeschke H (2022) The role of iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice. Toxicol Appl Pharmacol 445:116043","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR2","volume-title":"Acetaminophen toxicity","author":"S Agrawal","year":"2023","unstructured":"Agrawal S, Khazaeni B (2023) Acetaminophen toxicity. StatPearls Publishing StatPearls Publishing LLC, Treasure Island FL"},{"key":"3725_CR3","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1007\/s00204-021-03142-9","volume":"95","author":"JY Akakpo","year":"2021","unstructured":"Akakpo JY, Jaeschke MW, Ramachandran A, Curry SC, Rumack BH, Jaeschke H (2021) Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Arch Toxicol 95:3377\u20133391","journal-title":"Arch Toxicol"},{"key":"3725_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00204-021-03211-z","volume":"96","author":"JY Akakpo","year":"2022","unstructured":"Akakpo JY, Ramachandran A, Curry SC, Rumack BH, Jaeschke H (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Arch Toxicol 96:453\u2013465","journal-title":"Arch Toxicol"},{"key":"3725_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1667\/RR14896.1","volume":"190","author":"KA Ashcraft","year":"2018","unstructured":"Ashcraft KA, Choudhury KR, Birer SR, Hendargo HC, Patel P, Eichenbaum G, Dewhirst MW (2018) Application of a novel murine ear vein model to evaluate the effects of a vascular radioprotectant on radiation-induced vascular permeability and leukocyte adhesion. Radiat Res 190:12\u201321","journal-title":"Radiat Res"},{"key":"3725_CR6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/toxsci\/kfl077","volume":"94","author":"ML Bajt","year":"2006","unstructured":"Bajt ML, Cover C, Lemasters JJ, Jaeschke H (2006) Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury. Toxicol Sci 94:217\u2013225","journal-title":"Toxicol Sci"},{"key":"3725_CR7","doi-asserted-by":"publisher","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead P, Loughrey MB, Fern\u00e1ndez JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, James JA, Salto-Tellez M, Hamilton PW (2017) QuPath: open source software for digital pathology image analysis. Sci Rep 7:16878","journal-title":"Sci Rep"},{"key":"3725_CR8","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/toxsci\/kfw213","volume":"155","author":"B Bhushan","year":"2017","unstructured":"Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U (2017) Dual role of epidermal growth factor receptor in liver injury and regeneration after acetaminophen overdose in mice. Toxicol Sci 155:363\u2013378","journal-title":"Toxicol Sci"},{"key":"3725_CR9","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1016\/j.ajpath.2014.07.019","volume":"184","author":"B Bhushan","year":"2014","unstructured":"Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, Monga SP, Apte U (2014) Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model. Am J Pathol 184:3013\u20133025","journal-title":"Am J Pathol"},{"key":"3725_CR10","first-page":"477","volume":"21","author":"S Chanda","year":"1995","unstructured":"Chanda S, Mangipudy RS, Warbritton A, Bucci TJ, Mehendale HM (1995) Stimulated hepatic tissue repair underlies heteroprotection by thioacetamide against acetaminophen-induced lethality. Hepatology 21:477\u2013486","journal-title":"Hepatology"},{"key":"3725_CR11","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1038\/s41467-020-15584-3","volume":"11","author":"A Chauhan","year":"2020","unstructured":"Chauhan A, Sheriff L, Hussain MT, Webb GJ, Patten DA, Shepherd EL, Shaw R, Weston CJ, Haldar D, Bourke S, Bhandari R, Watson S, Adams DH, Watson SP, Lalor PF (2020) The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. Nat Commun 11:1939","journal-title":"Nat Commun"},{"key":"3725_CR12","doi-asserted-by":"publisher","first-page":"4054","DOI":"10.1182\/blood.V86.11.4054.bloodjournal86114054","volume":"86","author":"J Chen","year":"1995","unstructured":"Chen J, Herceg-Harjacek L, Groopman JE, Grabarek J (1995) Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 86:4054\u20134062","journal-title":"Blood"},{"key":"3725_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/bs.apha.2019.03.001","volume":"85","author":"MM Clemens","year":"2019","unstructured":"Clemens MM, McGill MR, Apte U (2019) Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Adv Pharmacol 85:241\u2013262","journal-title":"Adv Pharmacol"},{"key":"3725_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.1996.8074","volume":"143","author":"SD Cohen","year":"1997","unstructured":"Cohen SD, Pumford NR, Khairallah EA, Boekelheide K, Pohl LR, Amouzadeh HR, Hinson JA (1997) Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol 143:1\u201312","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR15","first-page":"864","volume":"232","author":"GB Corcoran","year":"1985","unstructured":"Corcoran GB, Racz WJ, Smith CV, Mitchell JR (1985) Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. J Pharmacol Exp Ther 232:864\u2013872","journal-title":"J Pharmacol Exp Ther"},{"key":"3725_CR16","first-page":"54","volume":"238","author":"GB Corcoran","year":"1986","unstructured":"Corcoran GB, Wong BK (1986) Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-l-cysteine in vivo: studies with N-acetyl-d-cysteine in mice. J Pharmacol Exp Ther 238:54\u201361","journal-title":"J Pharmacol Exp Ther"},{"key":"3725_CR17","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","volume":"35","author":"DM Dambach","year":"2002","unstructured":"Dambach DM, Watson LM, Gray KR, Durham SK, Laskin DL (2002) Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse. Hepatology 35:1093\u20131103","journal-title":"Hepatology"},{"key":"3725_CR18","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/S0006-2952(97)00048-8","volume":"53","author":"LD DeLeve","year":"1997","unstructured":"DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A (1997) Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol 53:1339\u20131345","journal-title":"Biochem Pharmacol"},{"key":"3725_CR19","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature09493","volume":"468","author":"BS Ding","year":"2010","unstructured":"Ding BS, Nolan DJ, Butler JM, James D, Babazadeh AO, Rosenwaks Z, Mittal V, Kobayashi H, Shido K, Lyden D, Sato TN, Rabbany SY, Rafii S (2010) Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468:310\u2013315","journal-title":"Nature"},{"key":"3725_CR20","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/ajh.2830450313","volume":"45","author":"M Fischereder","year":"1994","unstructured":"Fischereder M, Jaffe JP (1994) Thrombocytopenia following acute acetaminophen overdose. Am J Hematol 45:258\u2013259","journal-title":"Am J Hematol"},{"key":"3725_CR21","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/hep.21779","volume":"46","author":"PE Ganey","year":"2007","unstructured":"Ganey PE, Luyendyk JP, Newport SW, Eagle TM, Maddox JF, Mackman N, Roth RA (2007) Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice. Hepatology 46:1177\u20131186","journal-title":"Hepatology"},{"key":"3725_CR22","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.3324\/haematol.2018.212845","volume":"104","author":"W Ghanima","year":"2019","unstructured":"Ghanima W, Cooper N, Rodeghiero F, Godeau B, Bussel JB (2019) Thrombopoietin receptor agonists: ten years later. Haematologica 104:1112\u20131123","journal-title":"Haematologica"},{"key":"3725_CR23","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1016\/j.jtha.2023.03.040","volume":"21","author":"DJ Groeneveld","year":"2023","unstructured":"Groeneveld DJ, Poole LG, Bouck EG, Schulte A, Wei Z, Williams KJ, Watson VE, Lisman T, Wolberg AS, Luyendyk JP (2023) Robust coagulation activation and coagulopathy in mice with experimental acetaminophen-induced liver failure. J Thromb Haemost 21:2430\u20132440","journal-title":"J Thromb Haemost"},{"key":"3725_CR24","doi-asserted-by":"publisher","first-page":"13565","DOI":"10.1074\/jbc.M708916200","volume":"283","author":"N Hanawa","year":"2008","unstructured":"Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283:13565\u201313577","journal-title":"J Biol Chem"},{"key":"3725_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/bjh.12772","volume":"165","author":"IS Hitchcock","year":"2014","unstructured":"Hitchcock IS, Kaushansky K (2014) Thrombopoietin from beginning to end. Br J Haematol 165:259\u2013268","journal-title":"Br J Haematol"},{"key":"3725_CR26","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1080\/09537104.2021.1925102","volume":"32","author":"IS Hitchcock","year":"2021","unstructured":"Hitchcock IS, Hafer M, Sangkhae V, Tucker JA (2021) The thrombopoietin receptor: revisiting the master regulator of platelet production. Platelets 32:770\u2013778","journal-title":"Platelets"},{"key":"3725_CR27","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1189\/jlb.0308173","volume":"84","author":"MP Holt","year":"2008","unstructured":"Holt MP, Cheng L, Ju C (2008) Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 84:1410\u20131421","journal-title":"J Leukoc Biol"},{"key":"3725_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.toxlet.2010.01.020","volume":"194","author":"MP Holt","year":"2010","unstructured":"Holt MP, Yin H, Ju C (2010) Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of kupffer cells in mice. Toxicol Lett 194:34\u201341","journal-title":"Toxicol Lett"},{"key":"3725_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100754","volume":"3","author":"S Hu","year":"2022","unstructured":"Hu S, Liu S, Bian Y, Poddar M, Singh S, Cao C, McGaughey J, Bell A, Blazer LL, Adams JJ, Sidhu SS, Angers S, Monga SP (2022) Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b. Cell Rep Med 3:100754","journal-title":"Cell Rep Med"},{"key":"3725_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1478-3231.2011.02501.x","volume":"32","author":"H Jaeschke","year":"2012","unstructured":"Jaeschke H, Williams CD, Ramachandran A, Bajt ML (2012) Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int 32:8\u201320","journal-title":"Liver Int"},{"key":"3725_CR31","first-page":"153","volume":"2","author":"H Jaeschke","year":"2014","unstructured":"Jaeschke H, Xie Y, McGill MR (2014) Acetaminophen-induced liver injury: from animal models to humans. J Clin Transl Hepatol 2:153\u2013161","journal-title":"J Clin Transl Hepatol"},{"key":"3725_CR32","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","volume":"11","author":"H Jaeschke","year":"2021","unstructured":"Jaeschke H, Adelusi OB, Akakpo JY, Nguyen NT, Sanchez-Guerrero G, Umbaugh DS, Ding WX, Ramachandran A (2021a) Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls. Acta Pharm Sin B 11:3740\u20133755","journal-title":"Acta Pharm Sin B"},{"key":"3725_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104859","volume":"120","author":"H Jaeschke","year":"2021","unstructured":"Jaeschke H, Murray FJ, Monnot AD, Jacobson-Kram D, Cohen SM, Hardisty JF, Atillasoy E, Hermanowski-Vosatka A, Kuffner E, Wikoff D, Chappell GA, Bandara SB, Deore M, Pitchaiyan SK, Eichenbaum G (2021b) Assessment of the biochemical pathways for acetaminophen toxicity: implications for its carcinogenic hazard potential. Regul Toxicol Pharmacol 120:104859","journal-title":"Regul Toxicol Pharmacol"},{"key":"3725_CR34","first-page":"195","volume":"187","author":"DJ Jollow","year":"1973","unstructured":"Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB (1973) Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 187:195\u2013202","journal-title":"J Pharmacol Exp Ther"},{"key":"3725_CR35","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000469338","volume":"35","author":"K Jungermann","year":"1986","unstructured":"Jungermann K (1986) Functional heterogeneity of periportal and perivenous hepatocytes. Enzyme 35:161\u2013180","journal-title":"Enzyme"},{"key":"3725_CR36","first-page":"265","volume":"24","author":"K Kaushansky","year":"1996","unstructured":"Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC (1996) Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 24:265\u2013269","journal-title":"Exp Hematol"},{"key":"3725_CR37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1600-0676.1992.tb00571.x","volume":"12","author":"K Kayano","year":"1992","unstructured":"Kayano K, Yasunaga M, Kubota M, Takenaka K, Mori K, Yamashita A, Kubo Y, Sakaida I, Okita K, Sanuki K (1992) Detection of proliferating hepatocytes by immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in patients with acute hepatic failure. Liver 12:132\u2013136","journal-title":"Liver"},{"key":"3725_CR38","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/toxsci\/kfz029","volume":"169","author":"RC Kennedy","year":"2019","unstructured":"Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA (2019) Propagation of pericentral necrosis during acetaminophen-induced liver injury: evidence for early interhepatocyte communication and information exchange. Toxicol Sci 169:151\u2013166","journal-title":"Toxicol Sci"},{"key":"3725_CR39","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.4161\/cc.4.12.2197","volume":"4","author":"K Kirito","year":"2005","unstructured":"Kirito K, Kaushansky K (2005) Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells. Cell Cycle 4:1729\u20131731","journal-title":"Cell Cycle"},{"key":"3725_CR40","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/1091581811404708","volume":"30","author":"E Knight","year":"2011","unstructured":"Knight E, Eichenbaum G, Hillsamer V, Greway T, Tonelli A, Han-Hsu H, Zakszewski C, Yurkow E, Shukla U, End D, Louden C (2011) Nonclinical safety assessment of a synthetic peptide thrombopoietin agonist: effects on platelets, bone homeostasis, and immunogenicity and the implications for clinical safety monitoring of adverse bone effects. Int J Toxicol 30:385\u2013404","journal-title":"Int J Toxicol"},{"key":"3725_CR41","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/toxsci\/kfq175","volume":"117","author":"K Kon","year":"2010","unstructured":"Kon K, Kim JS, Uchiyama A, Jaeschke H, Lemasters JJ (2010) Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes. Toxicol Sci 117:101\u2013108","journal-title":"Toxicol Sci"},{"key":"3725_CR42","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","volume":"143","author":"P Kubes","year":"2012","unstructured":"Kubes P, Mehal WZ (2012) Sterile inflammation in the liver. Gastroenterology 143:1158\u20131172","journal-title":"Gastroenterology"},{"key":"3725_CR43","doi-asserted-by":"publisher","first-page":"481","DOI":"10.15403\/jgld-4715","volume":"31","author":"A Kusnik","year":"2022","unstructured":"Kusnik A, Mostafa MR, Hunter N, Sharma R, Jamal H, Hameed M (2022) Fomepizole as an emerging adjunct in treating severe acetaminophen toxicity: a case report and a brief review. J Gastrointestin Liver Dis 31:481\u2013482","journal-title":"J Gastrointestin Liver Dis"},{"key":"3725_CR44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12185-013-1382-0","volume":"98","author":"DJ Kuter","year":"2013","unstructured":"Kuter DJ (2013) The biology of thrombopoietin and thrombopoietin receptor agonists. Int J Hematol 98:10\u201323","journal-title":"Int J Hematol"},{"key":"3725_CR45","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/00498250802512830","volume":"39","author":"JE Laine","year":"2009","unstructured":"Laine JE, Auriola S, Pasanen M, Juvonen RO (2009) Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica 39:11\u201321","journal-title":"Xenobiotica"},{"key":"3725_CR46","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/hep.20948","volume":"42","author":"AM Larson","year":"2005","unstructured":"Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schi\u00f8dt FV, Ostapowicz G, Shakil AO, Lee WM (2005) Acetaminophen-induced acute liver failure: results of a united states multicenter, prospective study. Hepatology 42:1364\u20131372","journal-title":"Hepatology"},{"key":"3725_CR47","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","volume":"67","author":"WM Lee","year":"2017","unstructured":"Lee WM (2017) Acetaminophen (APAP) hepatotoxicity\u2014Isn\u2019t it time for APAP to go away? J Hepatol 67:1324\u20131331","journal-title":"J Hepatol"},{"key":"3725_CR48","doi-asserted-by":"publisher","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","volume":"271","author":"SST Lee","year":"1996","unstructured":"Lee SST, Buters JTM, Pineau T, Fernandez-Salguero P, Gonzalez FJ (1996) Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem 271:12063\u201312067","journal-title":"J Biol Chem"},{"key":"3725_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.828565","volume":"13","author":"A Licata","year":"2022","unstructured":"Licata A, Minissale MG, Stankevi\u010di\u016bt\u0117 S, Sanabria-Cabrera J, Lucena MI, Andrade RJ, Almasio PL (2022) N-acetylcysteine for preventing acetaminophen-induced liver Injury: a comprehensive review. Front Pharmacol 13:828565","journal-title":"Front Pharmacol"},{"key":"3725_CR50","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/clpt.2008.96","volume":"84","author":"M Liem-Moolenaar","year":"2008","unstructured":"Liem-Moolenaar M, Cerneus D, Molloy CJ, End D, Brown KH, de Kam ML, Cohen AF, van Hensbergen Y, Burggraaf J (2008) Pharmacodynamics and pharmacokinetics of the novel thrombopoietin mimetic peptide RWJ-800088 in humans. Clin Pharmacol Ther 84:481\u2013487","journal-title":"Clin Pharmacol Ther"},{"key":"3725_CR51","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1080\/15563650.2021.1996591","volume":"60","author":"SL Link","year":"2022","unstructured":"Link SL, Rampon G, Osmon S, Scalzo AJ, Rumack BH (2022) Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. Clin Toxicol (phila) 60:472\u2013477","journal-title":"Clin Toxicol (phila)"},{"key":"3725_CR52","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46206","volume":"9","author":"R Ma","year":"2020","unstructured":"Ma R, Mart\u00ednez-Ram\u00edrez AS, Borders TL, Gao F, Sosa-Pineda B (2020) Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal wnts. Elife 9:e46206","journal-title":"Elife"},{"key":"3725_CR53","first-page":"5","volume":"34","author":"RS McCuskey","year":"2006","unstructured":"McCuskey RS (2006) Sinusoidal endothelial cells as an early target for hepatic toxicants. Clin Hemorheol Microcirc 34:5\u201310","journal-title":"Clin Hemorheol Microcirc"},{"key":"3725_CR54","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3109\/15376516.2015.1094844","volume":"25","author":"MR McGill","year":"2015","unstructured":"McGill MR, Jaeschke H (2015) A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-vinylpyridine and N-ethylmaleimide. Toxicol Mech Methods 25:589\u2013595","journal-title":"Toxicol Mech Methods"},{"key":"3725_CR55","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/hep.24132","volume":"53","author":"MR McGill","year":"2011","unstructured":"McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE, Jaeschke H (2011) HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology 53:974\u2013982","journal-title":"Hepatology"},{"key":"3725_CR56","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","volume":"264","author":"MR McGill","year":"2012","unstructured":"McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H (2012) Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 264:387\u2013394","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR57","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.taap.2013.03.026","volume":"269","author":"MR McGill","year":"2013","unstructured":"McGill MR, Lebofsky M, Norris HR, Slawson MH, Bajt ML, Xie Y, Williams CD, Wilkins DG, Rollins DE, Jaeschke H (2013) Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol 269:240\u2013249","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR58","first-page":"185","volume":"187","author":"JR Mitchell","year":"1973","unstructured":"Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB (1973) Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 187:185\u2013194","journal-title":"J Pharmacol Exp Ther"},{"key":"3725_CR59","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/cpt1974164676","volume":"16","author":"JR Mitchell","year":"1974","unstructured":"Mitchell JR, Thorgeirsson SS, Potter WZ, Jollow DJ, Keiser H (1974) Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clin Pharmacol Ther 16:676\u2013684","journal-title":"Clin Pharmacol Ther"},{"key":"3725_CR60","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1182\/blood-2014-09-598656","volume":"125","author":"K Miyakawa","year":"2015","unstructured":"Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA (2015) Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood 125:1835\u20131843","journal-title":"Blood"},{"key":"3725_CR61","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S0301-472X(00)00624-X","volume":"29","author":"MA Mouthon","year":"2001","unstructured":"Mouthon MA, Gaugler MH, Van der Meeren A, Vandamme M, Gourmelon P, Wagemaker G (2001) Single administration of thrombopoietin to lethally irradiated mice prevents infectious and thrombotic events leading to mortality. Exp Hematol 29:30\u201340","journal-title":"Exp Hematol"},{"key":"3725_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.toxlet.2020.12.005","volume":"338","author":"NT Nguyen","year":"2021","unstructured":"Nguyen NT, Du K, Akakpo JY, Umbaugh DS, Jaeschke H, Ramachandran A (2021) Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice. Toxicol Lett 338:21\u201331","journal-title":"Toxicol Lett"},{"key":"3725_CR63","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00204-021-03183-0","volume":"96","author":"NT Nguyen","year":"2022","unstructured":"Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H (2022) Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Arch Toxicol 96:305\u2013320","journal-title":"Arch Toxicol"},{"key":"3725_CR64","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1002\/pds.1191","volume":"15","author":"P Nourjah","year":"2006","unstructured":"Nourjah P, Ahmad SR, Karwoski C, Willy M (2006) Estimates of acetaminophen (paracetomal)-associated overdoses in the united states. Pharmacoepidemiol Drug Saf 15:398\u2013405","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"3725_CR65","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1055\/s-0039-1679919","volume":"39","author":"A Ramachandran","year":"2019","unstructured":"Ramachandran A, Jaeschke H (2019) Acetaminophen hepatotoxicity. Semin Liver Dis 39:221\u2013234","journal-title":"Semin Liver Dis"},{"key":"3725_CR66","doi-asserted-by":"publisher","first-page":"724","DOI":"10.7326\/M15-2211","volume":"164","author":"A Reuben","year":"2016","unstructured":"Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Lee WM (2016) Outcomes in adults with acute liver failure between 1998 and 2013. Ann Intern Med 164:724\u2013732","journal-title":"Ann Intern Med"},{"key":"3725_CR67","first-page":"359","volume":"138","author":"DW Roberts","year":"1991","unstructured":"Roberts DW, Bucci TJ, Benson RW, Warbritton AR, McRae TA, Pumford NR, Hinson JA (1991) Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol 138:359\u2013371","journal-title":"Am J Pathol"},{"issue":"5 Pt 2 Suppl","key":"3725_CR68","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1542\/peds.62.5S.898","volume":"62","author":"BH Rumack","year":"1978","unstructured":"Rumack BH, Peterson RG (1978) Acetaminophen overdose: incidence, diagnosis, and management in 416 patients. Pediatrics 62(5 Pt 2 Suppl):898\u2013903","journal-title":"Pediatrics"},{"key":"3725_CR69","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.taap.2010.04.015","volume":"246","author":"C Saito","year":"2010","unstructured":"Saito C, Lemasters JJ, Jaeschke H (2010a) c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 246:8\u201317","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR70","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/hep.23267","volume":"51","author":"C Saito","year":"2010","unstructured":"Saito C, Zwingmann C, Jaeschke H (2010b) Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine. Hepatology 51:246\u2013254","journal-title":"Hepatology"},{"key":"3725_CR71","doi-asserted-by":"publisher","first-page":"16044","DOI":"10.1038\/sigtrans.2016.44","volume":"2","author":"K Shido","year":"2017","unstructured":"Shido K, Chavez D, Cao Z, Ko J, Rafii S, Ding BS (2017) Platelets prime hematopoietic and vascular niche to drive angiocrine-mediated liver regeneration. Signal Transduct Target Ther 2:16044","journal-title":"Signal Transduct Target Ther"},{"key":"3725_CR72","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez J-Y, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682","journal-title":"Nat Methods"},{"key":"3725_CR73","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1053\/jhep.2003.50113","volume":"37","author":"F Schi\u00f8dt","year":"2003","unstructured":"Schi\u00f8dt F (2003) Thrombopoietin in acute liver failure. Hepatology 37:558\u2013561","journal-title":"Hepatology"},{"key":"3725_CR74","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","volume":"319","author":"MJ Smilkstein","year":"1988","unstructured":"Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH (1988) Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. N Engl J Med 319:1557\u20131562","journal-title":"N Engl J Med"},{"key":"3725_CR75","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1053\/j.seminhematol.2010.03.005","volume":"47","author":"JN Thon","year":"2010","unstructured":"Thon JN, Italiano JE (2010) Platelet formation. Semin Hematol 47:220\u2013226","journal-title":"Semin Hematol"},{"key":"3725_CR76","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1046\/j.1365-2141.1998.01113.x","volume":"103","author":"Y Torii","year":"1998","unstructured":"Torii Y, Nitta Y, Akahori H, Tawara T, Kuwaki T, Ogami K, Kato T, Miyazaki H (1998) Mobilization of primitive haemopoietic progenitor cells and stem cells with long-term repopulating ability into peripheral blood in mice by pegylated recombinant human megakaryocyte growth and development factor. Br J Haematol 103:1172\u20131180","journal-title":"Br J Haematol"},{"key":"3725_CR77","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/toxsci\/kfab052","volume":"182","author":"DS Umbaugh","year":"2021","unstructured":"Umbaugh DS, Ramachandran A, Jaeschke H (2021) Spatial reconstruction of the early hepatic transcriptomic landscape after an acetaminophen overdose using single-cell RNA-sequencing. Toxicol Sci 182:327\u2013345","journal-title":"Toxicol Sci"},{"key":"3725_CR78","doi-asserted-by":"publisher","first-page":"6715","DOI":"10.7150\/thno.44900","volume":"10","author":"H Wang","year":"2020","unstructured":"Wang H, Burke LJ, Patel J, Tse BW, Bridle KR, Cogger VC, Li X, Liu X, Yang H, Crawford DHG, Roberts MS, Gao W, Liang X (2020) Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury. Theranostics 10:6715\u20136727","journal-title":"Theranostics"},{"key":"3725_CR79","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1034\/j.1600-0676.2003.00808.x","volume":"23","author":"AM Williams","year":"2003","unstructured":"Williams AM, Langley PG, Osei-Hwediah J, Wendon JA, Hughes RD (2003) Hyaluronic acid and endothelial damage due to paracetamol-induced hepatotoxicity. Liver Int 23:110\u2013115","journal-title":"Liver Int"},{"key":"3725_CR80","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.taap.2014.05.010","volume":"279","author":"Y Xie","year":"2014","unstructured":"Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H (2014) Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol 279:266\u2013274","journal-title":"Toxicol Appl Pharmacol"},{"key":"3725_CR81","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41467-019-09046-8","volume":"10","author":"W Yang","year":"2019","unstructured":"Yang W, Tao Y, Wu Y, Zhao X, Ye W, Zhao D, Fu L, Tian C, Yang J, He F, Tang L (2019) Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat Commun 10:1076","journal-title":"Nat Commun"},{"key":"3725_CR82","first-page":"131","volume":"4","author":"E Yoon","year":"2016","unstructured":"Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N (2016) Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol 4:131\u2013142","journal-title":"J Clin Transl Hepatol"}],"container-title":["Archives of Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03725-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00204-024-03725-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00204-024-03725-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T07:03:14Z","timestamp":1716188594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00204-024-03725-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["3725"],"URL":"https:\/\/doi.org\/10.1007\/s00204-024-03725-2","relation":{},"ISSN":["0340-5761","1432-0738"],"issn-type":[{"value":"0340-5761","type":"print"},{"value":"1432-0738","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,29]]},"assertion":[{"value":"21 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"GE and ES were employees of Johnson & Johnson; HJ was the recipient of research grants from Johnson & Johnson Consumer Health; all others have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}