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Cannabinoids may reduce certain types of pain, nausea, and anxiety. Anti-inflammatory and even anti-carcinogenic properties have been discussed. However, there are insufficient data available regarding their potential (geno-)toxic effects. Therefore, we tested CBG, CBD, CBC, CBDV, and CBN for their genotoxic potential and effects on mitosis and cell cycle in human lymphoblastoid TK6 cells. The selected cannabinoids (except CBDV) induced increased micronuclei formation, which was reduced with the addition of a metabolic activation system (S9 mix). CBDV induced micronuclei only after metabolic activation. Mitotic disturbances were observed with all tested cannabinoids, while G1 phase accumulation of cells was observed for CBG, CBD and CBDV. The genotoxic effects occurred at about 1000-fold higher concentrations than are reported as blood levels from human consumption. However, the results clearly indicate a need for further research into the genotoxic effects of cannabinoids. The mechanism of the mitotic disturbance, the shape of the dose\u2013response curves and the possible effects of mixtures of cannabinoids are aspects which need clarification.<\/jats:p>","DOI":"10.1007\/s00204-024-03826-y","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T14:49:16Z","timestamp":1724424556000},"page":"3439-3451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genotoxicity of selected cannabinoids in human lymphoblastoid TK6 cells"],"prefix":"10.1007","volume":"98","author":[{"given":"Nicol","family":"Kolar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7488-6228","authenticated-orcid":false,"given":"Ezgi Eyluel","family":"Bankoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-8211","authenticated-orcid":false,"given":"Helga","family":"Stopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"3826_CR1","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/jre.13050","volume":"57","author":"AH Abidi","year":"2022","unstructured":"Abidi AH, Abhyankar V, Alghamdi SS et al (2022) Phytocannabinoids regulate inflammation in IL-1\u03b2-stimulated human gingival fibroblasts. 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